phorbol-12-13-didecanoate and Skin-Neoplasms

phorbol-12-13-didecanoate has been researched along with Skin-Neoplasms* in 2 studies

Other Studies

2 other study(ies) available for phorbol-12-13-didecanoate and Skin-Neoplasms

Article	Year
Differential effects of phorbol ester tumor promoters on 3-methylcholanthrene-induced epithelial and mesenchymal skin tumorigenesis. Journal of cancer research and clinical oncology, 1988, Volume: 114, Issue:3 The effects of TPA, PDD, PDB, PDA, or MEZ on epithelial and mesenchymal skin tumors induced by a s.c. injection of MCA were studied histologically. Group-I mice received only MCA. At 6 weeks after MCA injection, mice in groups II to VII received acetone, 1.8 nmol TPA, PDD, PDB, PDA, or 6.1 nmol MEZ respectively in 0.1 ml acetone twice weekly until tumor development. Alterations in skin tumor induction patterns were also studied in animals that had been exposed to TPA or acetone for 10 weeks prior to s.c. injection of MCA. Exposure of mouse skin to TPA before or after carcinogen administration increased 2- to 3.5-fold, the incidence of carcinoma and mixed tumors of epithelial and mesenchymal histogenesis. The average time of tumor induction decreased in mice treated with MCA + TPA and 100% of the test animals in the TPA + MCA group developed tumors. In contrast, TPA-related phorbol esters inhibited skin tumor development, particularly trichoepithelioma and fibrosarcoma and increased the average time of tumor induction. Topics: Animals; Carcinoma; Diterpenes; Female; Mesenchymoma; Methylcholanthrene; Mice; Mice, Inbred Strains; Phorbol Esters; Skin Neoplasms; Terpenes; Tetradecanoylphorbol Acetate	1988
[Role of cell-cell interaction in tumor promotion]. Gan to kagaku ryoho. Cancer & chemotherapy, 1986, Volume: 13, Issue:3 Pt 2 Before a potentially tumorigenic cell meets a carcinogenic stimulus, its proliferation and differentiation are under tight control along with other neighbouring cells and their functions are well coordinated. In other words, cells in a given tissue form an orderly society and a cancer cell is a rebel against such a society. Therefore, it is important to study how the cellular society is maintained and how carcinogenic stimuli produce chaos in that society. The hypothesis that cell-cell interaction plays an important role in carcinogenesis has recently been reinforced by the finding that the prototype tumor promoter, phorbol esters, inhibits junctional intercellular communication. We present here several lines of evidence which suggest that block of intercellular communication is an important determinant in carcinogenesis, especially during tumor promotion process. Topics: Animals; Carcinogens; Cell Communication; Cell Transformation, Neoplastic; Cricetinae; Extracellular Space; Homeostasis; Mice; Mice, Inbred BALB C; Neoplasms, Experimental; Phorbol Esters; Protein Kinase C; Skin Neoplasms; Tetradecanoylphorbol Acetate	1986

Article

Year

Differential effects of phorbol ester tumor promoters on 3-methylcholanthrene-induced epithelial and mesenchymal skin tumorigenesis.

Journal of cancer research and clinical oncology, 1988, Volume: 114, Issue:3

The effects of TPA, PDD, PDB, PDA, or MEZ on epithelial and mesenchymal skin tumors induced by a s.c. injection of MCA were studied histologically. Group-I mice received only MCA. At 6 weeks after MCA injection, mice in groups II to VII received acetone, 1.8 nmol TPA, PDD, PDB, PDA, or 6.1 nmol MEZ respectively in 0.1 ml acetone twice weekly until tumor development. Alterations in skin tumor induction patterns were also studied in animals that had been exposed to TPA or acetone for 10 weeks prior to s.c. injection of MCA. Exposure of mouse skin to TPA before or after carcinogen administration increased 2- to 3.5-fold, the incidence of carcinoma and mixed tumors of epithelial and mesenchymal histogenesis. The average time of tumor induction decreased in mice treated with MCA + TPA and 100% of the test animals in the TPA + MCA group developed tumors. In contrast, TPA-related phorbol esters inhibited skin tumor development, particularly trichoepithelioma and fibrosarcoma and increased the average time of tumor induction.

Topics: Animals; Carcinoma; Diterpenes; Female; Mesenchymoma; Methylcholanthrene; Mice; Mice, Inbred Strains; Phorbol Esters; Skin Neoplasms; Terpenes; Tetradecanoylphorbol Acetate

1988

[Role of cell-cell interaction in tumor promotion].

Gan to kagaku ryoho. Cancer & chemotherapy, 1986, Volume: 13, Issue:3 Pt 2

Before a potentially tumorigenic cell meets a carcinogenic stimulus, its proliferation and differentiation are under tight control along with other neighbouring cells and their functions are well coordinated. In other words, cells in a given tissue form an orderly society and a cancer cell is a rebel against such a society. Therefore, it is important to study how the cellular society is maintained and how carcinogenic stimuli produce chaos in that society. The hypothesis that cell-cell interaction plays an important role in carcinogenesis has recently been reinforced by the finding that the prototype tumor promoter, phorbol esters, inhibits junctional intercellular communication. We present here several lines of evidence which suggest that block of intercellular communication is an important determinant in carcinogenesis, especially during tumor promotion process.

Topics: Animals; Carcinogens; Cell Communication; Cell Transformation, Neoplastic; Cricetinae; Extracellular Space; Homeostasis; Mice; Mice, Inbred BALB C; Neoplasms, Experimental; Phorbol Esters; Protein Kinase C; Skin Neoplasms; Tetradecanoylphorbol Acetate

1986