phorbol 12,13-dibutyrate has been researched along with Muscle Contraction in 175 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 28 (16.00) | 18.7374 |
| 1990's | 96 (54.86) | 18.2507 |
| 2000's | 36 (20.57) | 29.6817 |
| 2010's | 15 (8.57) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chiba, Y; Ikebe, M; Kai, Y; Sakai, H; Sato, K | 1 |
| Rattan, S; Singh, J | 1 |
| Eddinger, TJ; Hermanson, ME; Zhang, Y | 1 |
| Arner, A; Boberg, L; Poljakovic, M; Rahman, A | 1 |
| Chacko, S; Chang, S; Hypolite, JA; Malykhina, AP; Wein, AJ | 1 |
| George, S; Gupte, SA; Hintze, TH; Kaminski, PM; Kouznestova, L; Mathew, R; Olson, SC; Wolin, MS | 1 |
| Hayashi, Y; Nguyen, SV; Nguyen, TM; Purdy, RE; Summers, SM | 1 |
| Black, J; Brown, D; Bryda, EC; Dykes, A; Thatcher, S; Wright, GL | 1 |
| Elkins, R; Sathishkumar, K; Yallampalli, C; Yallampalli, U | 1 |
| Chiba, Y; Hashimoto, Y; Kurihara, Y; Misawa, M; Sakai, H | 3 |
| Heaps, CL; Parker, JL; Robles, JC; Sturek, M | 1 |
| Fultz, ME; Hagiwara, H; Hayakawa, K; Katayama, T; Kohama, K; Lin, Y; Nakamura, A; Tanaka, H; Thatcher, SE; Wang, HH; Watanabe, M; Wright, GL; Yoshiyama, S; Zhang, HL; Zhang, Y | 1 |
| Maxwell, PJ; Rattan, S; Singh, J | 1 |
| Aguiar, LA; Barbosa, R; Ceccatto, VM; Coelho-de-Souza, AN; dos Santos, HS; Lahlou, S; Leal-Cardoso, JH; Lemos, TL; Magalhães, PJ; Porto, RS; Zin, WA | 1 |
| Babu, GJ; Eddinger, TJ; Huang, Q; Periasamy, M | 1 |
| Anhê, GF; Antunes, E; Calixto, MC; De Nucci, G; Grant, AD; Leiria, LO; Lintomen, L; Mónica, FZ; Sollon, C; Zanesco, A | 1 |
| Haze, K; Kashiwagi, S; Kobayashi, S; Kuriyama, S; Kurokawa, T; Miwa, S; Mizukami, Y; Mogami, K; Nakao, F; Sato, M; Shirao, S; Suzuki, M; Todoroki-Ikeda, N | 1 |
| Nunes, JP | 1 |
| Cavallero, S; Damiano, P; de la Riva, I; Fernández, B; Mayer, M; Puyó, AM; Rosón, MI | 1 |
| Fultz, ME; Wright, GL | 1 |
| Egawa, M; Hori, M; Kanzaki, H; Karaki, H; Kim, YS; Nakazawa, H; Ozaki, H; Seto, M; Yasuda, K | 1 |
| Eto, Y; Kandabashi, T; Kunihiro, I; Matsumoto, Y; Miyata, K; Morishige, K; Nakayama, K; Obara, K; Shimokawa, H; Takahashi, S; Takeshita, A | 1 |
| Baltas, LG; Lamounier-Zepter, V; Morano, I | 1 |
| Dobashi, K; Endou, K; Iizuka, K; Ishizuka, T; Mori, M; Nakazawa, T; Tsukagoshi, H; Yoshii, A | 1 |
| Arner, A; Bonnevier, J | 1 |
| Fujita, A; Hata, F; Hirayama, N; Kitayama, M; Kushida, M; Takeuchi, T | 1 |
| Bespalova, ZhD; Khapchaev, AY; Krymsky, MA; Shirinsky, VP; Sidorova, MV; Vorotnikov, AV; Wang, CL | 1 |
| Burnstock, G; Smith, NC | 1 |
| Kamata, K; Kasuya, Y; Kobayashi, T; Matsumoto, T; Nishiyama, M | 1 |
| Buchholz, JN; Xiao, D; Zhang, L | 1 |
| Hasegawa, A; Hatano, Y; Kakutani, T; Mizumoto, K; Yu, J | 1 |
| Furness, JB; Poole, DP | 1 |
| Azuma, YT; Hata, F; Nakajima, H; Takeuchi, T | 1 |
| Dutka, TL; Lamb, GD; Murphy, RM; Stephenson, DG | 1 |
| Azarmi, Y; Babaei, H | 1 |
| Bennett, JL; Blair, KL; Pax, RA | 2 |
| Ihara, M; Miasiro, N; Paiva, AC; Yano, M | 1 |
| Clegg, JM; McKenna, TM; Williams, TJ | 1 |
| Giaid, A; Harrison, DG; Kurz, S; Münzel, T; Stewart, DJ | 1 |
| Fukao, M; Hattori, Y; Kanno, M; Kawasaki, H | 1 |
| Abebe, W; Agrawal, DK | 1 |
| Forster, C | 1 |
| Nishio, I; Sasajima, H; Shima, H; Toyoda, Y | 1 |
| Brophy, C; Isales, C; Rasmussen, H; Takuwa, Y; Throckmorton, D; Whitney, G; Yeh, J | 1 |
| Crevel, H; Marthan, R; Rossetti, M; Savineau, JP | 1 |
| Fujita, A; Hata, F; Nakajima, H; Nishio, H; Takeuchi, T | 1 |
| Ebina, S; Nakahata, N; Nakanishi, H; Yamamoto, K | 1 |
| Colussi, DJ; Merkel, LA; Perrone, MH; Rivera, LM | 1 |
| McCall, R; McGrath, JC; Nally, JE; Thomson, NC; Wakelam, MJ; Young, LC | 1 |
| Anai, N; Ishiguro, S; Miyamoto, A; Nishio, A; Sakaguchi, H | 1 |
| Black, JL; Yang, KX | 2 |
| Kassell, NF; Lee, KS; Sutter, B; Suzuki, S | 1 |
| Marala, RB; Mustafa, SJ | 1 |
| Bretschneider, E; Glusa, E; Paintz, M | 1 |
| Mino, T; Naka, M; Tanaka, T; Yuasa, U | 1 |
| Hurn, E; Wright, G | 1 |
| Duong, HN | 1 |
| Itoh, T; Suzuki, A; Watanabe, Y | 1 |
| Atagunduz, P; Katusić, ZS; Martin, R; Ozhan, M; Sill, JC | 1 |
| Conte Camerino, D; De Luca, A; Pierno, S; Tricarico, D | 1 |
| Ajao, P; Baldwin, DR; Cragoe, EJ; Knox, AJ | 1 |
| Fujimoto, M; Nakajima, S; Ueda, M | 1 |
| Ichikawa, K; Ito, M; Itoh, H; Konishi, T; Nakano, T; Okubo, S; Shimomura, A | 1 |
| Sauro, MD; Thomas, B | 1 |
| Bazan, E; Campbell, AK; Rapoport, RM | 1 |
| Gonzalez De La Fuente, P; Marthan, R; Savineau, JP | 1 |
| Ferreira, AT; Kanashiro, CA; Oshiro, ME; Paiva, AC; Paiva, TB; Shimuta, SI | 1 |
| Abdel-Latif, AA; Husain, S | 1 |
| Kokubu, N; Matsuo, K; Satoh, M; Takayanagi, I | 1 |
| Dang, S; Gerthoffer, WT; Haynes, R; Pohl, J; Sato, K; Sellers, JR; Shearer, M; Yamboliev, IA | 1 |
| Hatake, K; Masui, H; Sakamoto, K; Wakabayashi, I | 1 |
| Henke, R; Knipp, SC; Peiper, U; Thies, B | 1 |
| Keiser, HR; Oriji, GK | 3 |
| Ahn, SC; Kim, KW; Kim, SJ; Kim, YC; So, I | 1 |
| Fujitani, B; Hashizume, M; Hosoki, K; Masuda, Y; Minato, H | 1 |
| Ahn, HY; Chang, KC; Chung, MH; Kim, MS; Moreland, RS | 1 |
| Daniele, E; Lograno, MD; Villani, G | 1 |
| Linde, C; Löffler, C; Quast, U | 1 |
| Balfagón, G; Conde, MV; Encabo, A; Ferrer, M; Gómez-Gerique, JA; Marín, J; Porres, A | 1 |
| Gomi, Y; Tsunobuchi-Ushijima, H | 1 |
| Hano, T; Kimura, K; Nishio, I; Sasajima, H; Shima, H; Toyoda, Y; Yoshikawa, A | 1 |
| Masui, H; Wakabayashi, I | 1 |
| Burt, RP; Chapple, CR; Marshall, I | 1 |
| Lin, MJ; Lin-Shiau, SY; Liu, SH | 1 |
| Fukao, M; Hattori, Y; Kanno, M; Kitabatake, A; Sakuma, I; Sato, A | 1 |
| Camerino, C; Camerino, DC; De Luca, A; Huxtable, RJ; Pierno, S | 1 |
| Brophy, CM; Packer, CS; Throckmorton, DC | 1 |
| Gorenne, I; Kotlikoff, MI; Moreland, RS; Su, X; Yu, MF | 1 |
| Fu, X; Gong, MC; Jia, T; Somlyo, AP; Somlyo, AV | 1 |
| Barnes, PJ; Dupont, LJ; Mak, JC; Pype, JL; Verleden, GM | 1 |
| Hattori, Y; Kanno, M; Kitabatake, A; Kohya, T; Moriishi, K; Oguma, K; Sasaki, M; Tomita, F | 1 |
| Sun, JH; Zhang, XH; Zhu, PH | 1 |
| Blase, DK; Cohen, ML; Cox, DA | 1 |
| Eto, M; Ikebe, M; Kitazawa, T; Takizawa, N | 1 |
| Gregory, LG; Keef, KD; Khoyi, MA; Smith, AD; Westfall, DP | 1 |
| Chibalina, MV; Krymskiĭ, MA; Kudriashov, DS; Shirinskiĭ, VP; Vorotnikov, AV | 1 |
| Kanashiro, CA; Khalil, RA | 1 |
| Hashimoto, K; Igarashi, T; Imai, T; Mitani, A; Nakazawa, T; Noguchi, K; Otsuka, K; Saitoh, M; Shigenobu, K; Someya, S; Tanaka, H; Tanaka, Y; Yamaki, F | 1 |
| Zhang, XH; Zhu, PH | 1 |
| Fultz, ME; Geng, W; Li, C; Wright, GL | 1 |
| Brautigan, DL; Eto, M; Kitazawa, T; Mukai, H; Ono, Y; Yazawa, M | 1 |
| Fujishima, M; Hirano, K; Ibayashi, S; Kanaide, H; Nakamura, K; Nishimura, J | 1 |
| Brautigan, DL; Eto, M; Everett, A; Kitazawa, T; Woodsome, TP | 1 |
| Bhalla, J; Brophy, CM; Dransfield, DT; Komalavilas, P; Mehta, S; Molinaro, JR; Wingard, CJ; Woodrum, JE | 1 |
| Groschner, K; Masui, H; Wakabayashi, I | 1 |
| Iwata, N; Kataoka, Y; Masui, H; Wakabayashi, I | 1 |
| Xiao, D; Zhang, L | 1 |
| Koizumi, N; Masui, H; Siogawa, K; Wakabayashi, I | 1 |
| Krymsky, MA; Kudryashov, DS; Lukas, TJ; Shirinsky, VP; Vorotnikov, AV; Watterson, DM | 1 |
| Aboulafia, J; Nouailhetas, VL; Silva, BA | 1 |
| Azhar, S; Hoffman, BB; Hu, Z | 1 |
| Goto, K; Kasuya, Y; Masaki, T; Takuwa, Y; Yanagisawa, M | 1 |
| Baines, RA; Downer, RG | 1 |
| Benscoter, H; Schworer, CM; Singer, HA; Sweeley, C | 1 |
| Ikeda, K; Machida, J; Nishi, K; Sakiyama, H; Ueda, S; Yoshida, M | 1 |
| Fukaya, Y; Shiraiwa, Y; Yamaguchi, O; Yokota, T; Yoshimura, Y | 1 |
| Bárány, K; Bárány, M; Polyák, E | 1 |
| Cumiskey, WR; Harris, AL; Silver, PJ | 1 |
| Bast, A; Brozius, MM; Jansen, W; Leurs, R; Smit, MJ; Timmerman, H | 1 |
| Lowe, VC; Noronha-Blob, L | 1 |
| Miyata, N; Otomo, S; Tsuchida, K | 2 |
| Crevel, H; Marthan, R; Savineau, JP | 1 |
| Daniele, E; Govoni, S; Lograno, MD; Trabucchi, M | 1 |
| Cushing, DJ; Makujina, SR; Mustafa, SJ; Sabouni, MH | 1 |
| Kageyama, M; Mori, T; Taira, N; Yanagisawa, T | 1 |
| Broadley, KJ; Urquhart, RA | 1 |
| Higuchi, H; Hiraoka, N; Ito, M; Itoh, H; Konishi, T; Lederis, K; Nakano, T | 1 |
| Abe, Y; Goto, K; Kasuya, Y; Kudo, M; Masaki, T; Takuwa, Y; Yamashita, K | 1 |
| Kato, H; Ozawa, J; Takata, Y | 1 |
| Cohen, ML; Lucaites, VL; Mendelsohn, LG; Secrest, RJ | 1 |
| Bárány, K; Bárány, M; Rokolya, A | 2 |
| Clark, AH; Garland, CJ | 1 |
| Guthrie, TS; Tsuji, J; Wells, JN | 1 |
| Auguet, M; Braquet, P; Chabrier, PE; Delaflotte, S | 2 |
| Fitzpatrick, DF; Sauro, MD | 1 |
| Abel, KC; Clark, MG; Cleland, PJ; Rattigan, S | 1 |
| Singer, HA | 1 |
| Balfagón, G; Barrús, MT; Marín, J; Salaíces, M | 1 |
| García-Sáinz, JA; Hong, E; Ransanz, V; Torres-Márquez, ME; Villalobos-Molina, R | 1 |
| Cheung, DW; MacKay, MJ | 1 |
| Litten, RZ; Roth, BL; Suba, EA | 1 |
| Dale, MM; Hirst, SJ; Obianime, AW | 2 |
| Hai, CM; Murphy, RA; Ratz, PH | 1 |
| Desiderio, D; Johns, A; Luisi, A; Rubanyi, GM; Sybertz, EJ | 1 |
| McKenna, TM; Titius, WA | 1 |
| Lueders, JE; McKenna, TM; Titius, WA | 1 |
| Nishimura, J; van Breemen, C | 1 |
| Sasaguri, T; Watson, SP | 1 |
| Hsu, LC; Kamm, KE; Kubota, Y; Stull, JT | 1 |
| Baba, K; Baron, CB; Coburn, RF | 1 |
| Dale, MM; Obianime, AW | 2 |
| Carcillo, JA; Litten, RZ; Roth, BL | 1 |
| Abdel-Latif, AA; Akhtar, RA; Howe, PH; Naderi, S | 1 |
| Chiu, PJ; Desiderio, DM; Sybertz, EJ; Tetzloff, G | 1 |
| Gerthoffer, WT | 1 |
| Cumiskey, WR; Harris, AL; Kiefer, D; Lepore, RE; Silver, PJ | 1 |
| Chatterjee, M; Chiu, PJ; Sybertz, EJ; Tetzloff, G | 1 |
| Murphy, RA; Rembold, CM | 1 |
| Hatake, K; Hishida, S; Kakishita, E; Nagai, K; Wakabayashi, I | 1 |
| Chatterjee, M; Tejada, M | 1 |
| Flaim, SF; Gleason, MM | 1 |
| Hawkins, DJ; Miller, JR; Wells, JN | 1 |
| Marmé, D; Schächtele, C; Wagner, B | 1 |
| Chatterjee, M; Foster, C | 1 |
175 other study(ies) available for phorbol 12,13-dibutyrate and Muscle Contraction
| Article | Year |
|---|---|
Rac1 modulates G-protein-coupled receptor-induced bronchial smooth muscle contraction.
Topics: Animals; Bronchi; Carbachol; Endothelin-1; Male; Marine Toxins; Muscle Contraction; Muscle, Smooth; Myosin Light Chains; Oxazoles; Phorbol 12,13-Dibutyrate; Phosphorylation; Potassium; Protein Phosphatase 1; rac1 GTP-Binding Protein; Rats; Rats, Wistar; Receptors, G-Protein-Coupled | 2018 |
Role of PKC and RhoA/ROCK pathways in the spontaneous phasic activity in the rectal smooth muscle.
Topics: Amides; Animals; Carcinogens; Enzyme Inhibitors; Fecal Incontinence; Indoles; Maleimides; Muscle Contraction; Muscle, Smooth; Naphthalenes; Phorbol 12,13-Dibutyrate; Phosphorylation; Protein Kinase C; Pyridines; Rats; Rats, Sprague-Dawley; Rectum; rho-Associated Kinases; rhoA GTP-Binding Protein; Signal Transduction | 2013 |
Tonic and phasic smooth muscle contraction is not regulated by the PKCα - CPI-17 pathway in swine stomach antrum and fundus.
Topics: Animals; Biomechanical Phenomena; Carbachol; Gastric Fundus; Muscle Contraction; Muscle, Smooth; Myosin-Light-Chain Phosphatase; Phorbol 12,13-Dibutyrate; Protein Kinase C-alpha; Pyloric Antrum; Signal Transduction; Sus scrofa | 2013 |
Protein kinase C activation of a blebbistatin sensitive contractile component in the wall of hypertrophying mouse urinary bladder.
Topics: Animals; Biomechanical Phenomena; Disease Models, Animal; Female; Heterocyclic Compounds, 4 or More Rings; Hypertrophy; In Vitro Techniques; Mice; Mice, Inbred C57BL; Muscle Contraction; Muscle, Smooth; Nonmuscle Myosin Type IIB; Phorbol 12,13-Dibutyrate; Protein Kinase C; Urinary Bladder; Urinary Bladder Neck Obstruction | 2015 |
Protein kinase C modulates frequency of micturition and non-voiding contractions in the urinary bladder via neuronal and myogenic mechanisms.
Topics: Animals; Dose-Response Relationship, Drug; Male; Muscle Contraction; Phorbol 12,13-Dibutyrate; Phorbol Esters; Protein Kinase C; Rats, Sprague-Dawley; Urinary Bladder; Urination | 2015 |
Peroxide generation by p47phox-Src activation of Nox2 has a key role in protein kinase C-induced arterial smooth muscle contraction.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Aorta; Cattle; Coronary Vessels; Membrane Glycoproteins; Mice; Muscle Contraction; Muscle, Smooth, Vascular; NADPH Oxidase 2; NADPH Oxidases; Nitroglycerin; Peroxides; Phorbol 12,13-Dibutyrate; Protein Kinase C; Reactive Oxygen Species; Receptors, Thromboxane; src-Family Kinases; Superoxides; Vasoconstriction; Vasoconstrictor Agents; Vasodilator Agents | 2009 |
Hindlimb unweighting induces changes in the p38MAPK contractile pathway of the rat abdominal aorta.
Topics: Adrenergic alpha-Agonists; Animals; Aorta, Abdominal; Butadienes; Disease Models, Animal; Enzyme Inhibitors; Hindlimb Suspension; HSP27 Heat-Shock Proteins; Imidazoles; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; Nitriles; p38 Mitogen-Activated Protein Kinases; Phenylephrine; Phorbol 12,13-Dibutyrate; Pyridines; Rats; Rats, Wistar; Signal Transduction | 2009 |
FRET analysis of actin-myosin interaction in contracting rat aortic smooth muscle.
Topics: Actins; Animals; Aorta; Cells, Cultured; Fluorescence Resonance Energy Transfer; Male; Muscle Contraction; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Myosins; Phorbol 12,13-Dibutyrate; Rats; Rats, Sprague-Dawley | 2009 |
Raf-1 kinase regulates smooth muscle contraction in the rat mesenteric arteries.
Topics: Animals; Blood Pressure; Calcium; Female; Indoles; Mesenteric Arteries; Mitogen-Activated Protein Kinase Kinases; Muscle Contraction; Myosin Light Chains; Phenols; Phenylephrine; Phorbol 12,13-Dibutyrate; Protein Phosphatase 1; Proto-Oncogene Proteins c-raf; Rats; Rats, Sprague-Dawley | 2010 |
Phorbol 12,13-dibutyrate-mediated contraction of the stimulated bronchial smooth muscles of mice.
Topics: Acetylcholine; Animals; Bronchi; Calcimycin; Cysteine Endopeptidases; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; In Vitro Techniques; Indoles; Ionophores; Male; Maleimides; Mice; Muscle Contraction; Muscle, Smooth; Phorbol 12,13-Dibutyrate; Potassium; Smooth Muscle Myosins | 2010 |
Involvement of multiple PKC isoforms in phorbol 12,13-dibutyrate-induced contraction during high K(+) depolarization in bronchial smooth muscle of mice.
Topics: Animals; Bronchi; Carcinogens; Isoenzymes; Male; Mice; Mice, Inbred BALB C; Muscle Contraction; Muscle Tonus; Muscle, Smooth; Phorbol 12,13-Dibutyrate; Potassium; Protein Kinase C; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger | 2010 |
Augmented PDBu-mediated contraction of bronchial smooth muscle of mice with antigen-induced airway hyperresponsiveness.
Topics: Acetylcholine; Animals; Bronchi; Bronchial Hyperreactivity; Carcinogens; Male; Mice; Mice, Inbred BALB C; Muscle Contraction; Muscle, Smooth; Ovalbumin; Phorbol 12,13-Dibutyrate; Protein Kinase C | 2010 |
Ca2+ sensitization and PKC contribute to exercise training-enhanced contractility in porcine collateral-dependent coronary arteries.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Calcium; Collateral Circulation; Coronary Vessels; Endothelin-1; Enzyme Inhibitors; Female; Muscle Contraction; Naphthalenes; Phorbol 12,13-Dibutyrate; Physical Conditioning, Animal; Protein Kinase C; Pyridines; rho-Associated Kinases; Swine; Vasodilator Agents | 2011 |
Myosin light chain kinase/actin interaction in phorbol dibutyrate-stimulated smooth muscle cells.
Topics: Actins; Animals; Cell Line; Cell Surface Extensions; Chickens; Cytoskeleton; Enzyme Inhibitors; Gene Silencing; Guinea Pigs; In Vitro Techniques; Kinetics; Microfilament Proteins; Muscle Contraction; Muscle, Smooth; Myocytes, Smooth Muscle; Myosin-Light-Chain Kinase; Myosins; Peptide Fragments; Phorbol 12,13-Dibutyrate; Phosphorylation; Protein Isoforms; Protein Processing, Post-Translational; Rats; RNA, Small Interfering | 2011 |
Immunocytochemical evidence for PDBu-induced activation of RhoA/ROCK in human internal anal sphincter smooth muscle cells.
Topics: ADP Ribose Transferases; Amides; Anal Canal; Botulinum Toxins; Cells, Cultured; Fluorescent Antibody Technique; Humans; Muscle Contraction; Myocytes, Smooth Muscle; Myosin-Light-Chain Phosphatase; Naphthalenes; Phorbol 12,13-Dibutyrate; Protein Kinase C-alpha; Pyridines; rho-Associated Kinases; rhoA GTP-Binding Protein; Signal Transduction | 2011 |
Antispasmodic effects of a new kaurene diterpene isolated from Croton argyrophylloides on rat airway smooth muscle.
Topics: Acetylcholine; Animals; Calcium; Calcium Channels; Carcinogens; Croton; Diterpenes, Kaurane; Electric Stimulation; Epinephrine; Inositol Phosphates; Male; Muscle Contraction; Muscle, Smooth; Parasympatholytics; Phorbol 12,13-Dibutyrate; Plant Extracts; Potassium; Rats; Rats, Wistar; Sarcoplasmic Reticulum; Serotonin; Trachea | 2012 |
SMB myosin heavy chain knockout enhances tonic contraction and reduces the rate of force generation in ileum and stomach antrum.
Topics: Animals; Carbachol; Cholinergic Agonists; Ileum; Mice; Mice, Knockout; Muscle Contraction; Muscle Strength; Muscle, Smooth; Myosin Heavy Chains; Phorbol 12,13-Dibutyrate; Phosphorylation; Potassium; Protein Kinase C-alpha; Pyloric Antrum; Second Messenger Systems; Smooth Muscle Myosins | 2013 |
Role of PKC and CaV1.2 in detrusor overactivity in a model of obesity associated with insulin resistance in mice.
Topics: Adiposity; Amlodipine; Animals; Body Weight; Calcium Channel Blockers; Calcium Channels, L-Type; Calcium Chloride; Carbachol; Disease Models, Animal; Epididymis; In Vitro Techniques; Insulin; Insulin Resistance; Male; Metformin; Mice; Mice, Inbred C57BL; Mice, Obese; Muscle Contraction; Obesity; Organ Size; Phorbol 12,13-Dibutyrate; Potassium Chloride; Protein Kinase C; Thinness; Urinary Bladder, Overactive | 2012 |
Sphingosylphosphorylcholine is a novel messenger for Rho-kinase-mediated Ca2+ sensitization in the bovine cerebral artery: unimportant role for protein kinase C.
Topics: Animals; Calcium Signaling; Cattle; Cell Membrane; Cell Membrane Permeability; Cells, Cultured; Cerebral Arteries; Culture Techniques; Enzyme Inhibitors; Escin; GTP-Binding Proteins; Intracellular Signaling Peptides and Proteins; Kinetics; Muscle Contraction; Muscle, Smooth, Vascular; Phorbol 12,13-Dibutyrate; Phosphorylcholine; Protein Kinase C; Protein Serine-Threonine Kinases; rho-Associated Kinases; Sphingosine | 2002 |
Cytoskeleton, passive tension and the contraction of the rat aorta to phorbol 12,13-dibutyrate.
Topics: Actins; Animals; Aorta, Thoracic; Body Weight; Colchicine; Cytochalasin B; Cytoskeleton; Hypertension; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; Phorbol 12,13-Dibutyrate; Protein Kinase C; Rats; Rats, Inbred SHR; Rats, Wistar; Tubulin Modulators | 2002 |
Impaired response to insulin associated with protein kinase C in chronic fructose-induced hypertension.
Topics: Animals; Atrial Natriuretic Factor; Blood Pressure; Body Weight; Enzyme Activators; Enzyme Inhibitors; Fructose; Hypertension; Hypoglycemic Agents; Insulin; Insulin Resistance; Male; Muscle Contraction; Muscle, Smooth, Vascular; Naphthalenes; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Phorbol 12,13-Dibutyrate; Protein Kinase C; Rats; Rats, Sprague-Dawley | 2002 |
Myosin remodelling in the contracting A7r5 smooth muscle cell.
Topics: Actins; Animals; Cells, Cultured; Cytochalasin B; Enzyme Inhibitors; Immunohistochemistry; Microscopy, Confocal; Muscle Contraction; Muscle, Smooth; Myosin Type II; Phorbol 12,13-Dibutyrate; Thapsigargin | 2003 |
Possible role of the protein kinase C/CPI-17 pathway in the augmented contraction of human myometrium after gestation.
Topics: Adult; Blotting, Western; Calcium; Carbazoles; Enzyme Activators; Enzyme Inhibitors; Female; Humans; Indoles; Intracellular Signaling Peptides and Proteins; Isoenzymes; Maleimides; Muscle Contraction; Muscle Proteins; Myometrium; Myosin Light Chains; Phorbol 12,13-Dibutyrate; Phosphoprotein Phosphatases; Phosphoproteins; Phosphorylation; Pregnancy; Pregnancy Trimester, Third; Protein Kinase C; RNA, Messenger; Serine; Type C Phospholipases; Uterine Contraction | 2003 |
Evidence for protein kinase C-mediated activation of Rho-kinase in a porcine model of coronary artery spasm.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Blotting, Western; Calcium; Capillary Permeability; Coronary Vasospasm; Coronary Vessels; Disease Models, Animal; Enzyme Activation; Enzyme Inhibitors; Guanosine 5'-O-(3-Thiotriphosphate); In Vitro Techniques; Intracellular Signaling Peptides and Proteins; Male; Monomeric GTP-Binding Proteins; Muscle Contraction; Muscle, Smooth, Vascular; Phorbol 12,13-Dibutyrate; Protein Kinase C; Protein Serine-Threonine Kinases; Protein Transport; rho-Associated Kinases; Swine | 2003 |
Distinct contractile systems for electromechanical and pharmacomechanical coupling in smooth muscle.
Topics: Alternative Splicing; Animals; Animals, Newborn; Azepines; Dose-Response Relationship, Drug; Electrophysiology; Enzyme Inhibitors; Exons; Genotype; Homozygote; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Muscle Contraction; Muscle, Smooth; Myosins; Naphthalenes; Phorbol 12,13-Dibutyrate; Phosphorylation; Potassium Chloride; Protein Isoforms; Protein Kinase C | 2003 |
8-Bromo-cAMP decreases the Ca2+ sensitivity of airway smooth muscle contraction through a mechanism distinct from inhibition of Rho-kinase.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Bronchi; Calcium; Carbachol; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Intracellular Signaling Peptides and Proteins; Muscle Contraction; Muscle, Smooth; Phorbol 12,13-Dibutyrate; Protein Serine-Threonine Kinases; Rabbits; rho-Associated Kinases; Trachea | 2004 |
Actions downstream of cyclic GMP/protein kinase G can reverse protein kinase C-mediated phosphorylation of CPI-17 and Ca²⁺ sensitization in smooth muscle.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Amides; Animals; Bacterial Toxins; Blood Vessels; Calcium; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Enzyme Inhibitors; Escin; Female; Guanosine 5'-O-(3-Thiotriphosphate); In Vitro Techniques; Intestine, Small; Intracellular Signaling Peptides and Proteins; Mice; Mice, Inbred Strains; Muscle Contraction; Muscle, Smooth; Permeability; Phorbol 12,13-Dibutyrate; Phosphorylation; Protein Kinase C; Protein Serine-Threonine Kinases; Pyridines; rho-Associated Kinases | 2004 |
Mechanisms involved in carbachol-induced Ca(2+) sensitization of contractile elements in rat proximal and distal colon.
Topics: ADP Ribose Transferases; Alkaloids; Amides; Animals; Bacterial Toxins; Benzophenanthridines; Botulinum Toxins; Calcium; Carbachol; Cell Membrane Permeability; Colon, Ascending; Colon, Descending; Escin; Guanosine Triphosphate; Hemolysin Proteins; Intracellular Signaling Peptides and Proteins; Japan; Male; Muscle Contraction; Myocytes, Smooth Muscle; Peptide Fragments; Phenanthridines; Phorbol 12,13-Dibutyrate; Protein Kinase C; Protein Serine-Threonine Kinases; Pyridines; Rats; Rats, Wistar; Receptors, Muscarinic; rho-Associated Kinases; Tritium; Type C Phospholipases | 2004 |
Novel phosphospecific antibodies for monitoring phosphorylation of proteins encoded by the myosin light chain kinase genetic locus.
Topics: Amino Acid Sequence; Animals; Calcium; Colforsin; Cyclic AMP-Dependent Protein Kinases; Male; Mitogen-Activated Protein Kinases; Molecular Sequence Data; Muscle Contraction; Muscle, Smooth; Myosin-Light-Chain Kinase; Peptide Fragments; Phorbol 12,13-Dibutyrate; Phosphorylation; Rats; Sequence Homology, Amino Acid; Serine; Signal Transduction | 2004 |
Mechanisms underlying postjunctional synergism between responses of the vas deferens to noradrenaline and ATP.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Adrenergic alpha-Antagonists; Animals; Cantharidin; Dose-Response Relationship, Drug; Drug Synergism; Electric Stimulation; Enzyme Inhibitors; Guinea Pigs; Histamine; Intracellular Signaling Peptides and Proteins; Male; Muscle Contraction; Muscle, Smooth; Naphthalenes; Norepinephrine; Phorbol 12,13-Dibutyrate; Phosphoprotein Phosphatases; Prazosin; Protein Kinase C; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; rho-Associated Kinases; Vas Deferens | 2004 |
Effect of phorbol 12,13-dibutyrate on smooth muscle tone in rat stomach fundus.
Topics: Animals; Calcium Chloride; Carbachol; Dose-Response Relationship, Drug; Endothelin-1; Gastric Fundus; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxation; Muscle Tonus; Muscle, Smooth; Phorbol 12,13-Dibutyrate; Phosphorylcholine; Rats; Rats, Wistar; Serotonin | 2005 |
Pregnancy attenuates uterine artery pressure-dependent vascular tone: role of PKC/ERK pathway.
Topics: Animals; Arteries; Blood Pressure; Calcium; Calcium Signaling; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Female; Flavonoids; In Vitro Techniques; Muscle Contraction; Muscle Tonus; Muscle, Smooth, Vascular; Phorbol 12,13-Dibutyrate; Pregnancy; Protein Kinase C; Regional Blood Flow; Sheep; Signal Transduction; Uterus; Vascular Resistance | 2006 |
Propofol inhibits phorbol 12, 13-dibutyrate-induced, protein kinase C-mediated contraction of rat aortic smooth muscle.
Topics: Anesthetics, Intravenous; Animals; Aorta, Thoracic; Blotting, Western; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Endothelium, Vascular; Enzyme Inhibitors; In Vitro Techniques; Indoles; Isometric Contraction; Male; Maleimides; Muscle Contraction; Muscle, Smooth, Vascular; Phorbol 12,13-Dibutyrate; Phosphorylation; Propofol; Protein Kinase C; Rats; Rats, Wistar | 2006 |
PKC delta-isoform translocation and enhancement of tonic contractions of gastrointestinal smooth muscle.
Topics: Animals; Carbachol; Cytoplasm; Cytoskeleton; Diacylglycerol Kinase; Diterpenes; Female; Guinea Pigs; Ileum; In Vitro Techniques; Indoles; Isoenzymes; Male; Maleimides; Muscle Contraction; Muscle, Smooth; Naphthalenes; Phorbol 12,13-Dibutyrate; Phosphorylation; Protein Kinase C; Protein Kinase C-delta; Protein Kinase C-epsilon; Protein Kinase Inhibitors; Protein Transport; Scopolamine; Subcellular Fractions | 2007 |
A minor role for Ca2+ sensitization in sustained contraction through activation of muscarinic receptor in circular muscle of rat distal colon.
Topics: Alkaloids; Amides; Animals; Benzophenanthridines; Calcium; Carbachol; Carcinogens; Cholinergic Agonists; Colon; Dose-Response Relationship, Drug; Guanosine Triphosphate; Male; Muscle Contraction; Muscle Relaxants, Central; Muscle, Smooth; Phorbol 12,13-Dibutyrate; Pyridines; Rats; Rats, Wistar; Receptors, Muscarinic | 2007 |
Chloride conductance in the transverse tubular system of rat skeletal muscle fibres: importance in excitation-contraction coupling and fatigue.
Topics: Action Potentials; Animals; Anthracenes; Chloride Channels; Chlorides; Electric Stimulation; Male; Muscle Contraction; Muscle Fatigue; Muscle Fibers, Skeletal; Muscle, Skeletal; Phorbol 12,13-Dibutyrate; Potassium; Rats; Rats, Long-Evans; Sodium-Potassium-Exchanging ATPase | 2008 |
17beta-estradiol inhibits calcium-dependent and -independent contractions in isolated human saphenous vein.
Topics: Calcium; Dose-Response Relationship, Drug; Estradiol; Humans; In Vitro Techniques; Muscle Contraction; Phorbol 12,13-Dibutyrate; Saphenous Vein | 2008 |
Serotonin and acetylcholine: further analysis of praziquantel-induced contraction of magnesium-paralysed Schistosoma mansoni.
Topics: 1-Methyl-3-isobutylxanthine; 4-Aminopyridine; Amifampridine; Animals; Arecoline; Carbachol; Colforsin; Dose-Response Relationship, Drug; In Vitro Techniques; Ions; Magnesium; Male; Muscle Contraction; Paralysis; Phorbol 12,13-Dibutyrate; Praziquantel; Schistosoma mansoni; Serotonin | 1993 |
Two receptor subtypes are involved in the contractile component of the guinea pig ileum responses to endothelins.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amino Acid Sequence; Animals; Endothelin Receptor Antagonists; Endothelins; Guinea Pigs; Ileum; In Vitro Techniques; Isoquinolines; Molecular Sequence Data; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Peptides, Cyclic; Phorbol 12,13-Dibutyrate; Piperazines; Protein Kinase C; Receptors, Endothelin | 1993 |
Protein kinase C is a mediator of lipopolysaccharide-induced vascular suppression in the rat aorta.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amino Acid Oxidoreductases; Animals; Aorta; Arginine; Cell Membrane; Citrulline; Cycloheximide; Cytosol; Dose-Response Relationship, Drug; Endothelium, Vascular; In Vitro Techniques; Isoquinolines; Kinetics; Lipopolysaccharides; Male; Muscle Contraction; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Phorbol 12,13-Dibutyrate; Piperazines; Potassium Chloride; Protein Kinase Inhibitors; Protein Kinases; Rats; Rats, Sprague-Dawley; Stereoisomerism; Sulfonamides | 1994 |
Evidence for a role of endothelin 1 and protein kinase C in nitroglycerin tolerance.
Topics: Alkaloids; Angiotensin II; Animals; Aorta, Thoracic; Drug Tolerance; Endothelins; Female; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; Naphthalenes; Nitroglycerin; Phenylephrine; Phorbol 12,13-Dibutyrate; Polycyclic Compounds; Potassium Chloride; Protein Kinase C; Rabbits; Serotonin; Staurosporine; Vasoconstriction | 1995 |
Phorbol esters elicit Ca(2+)-dependent delayed contractions in diabetic rat aorta.
Topics: Alkaloids; Animals; Aorta; Body Weight; Calcium; Diabetes Mellitus, Experimental; Male; Muscle Contraction; Muscle, Smooth, Vascular; Organ Size; Phorbol 12,13-Dibutyrate; Phorbol Esters; Protein Kinase C; Rats; Rats, Wistar; Staurosporine; Tetradecanoylphorbol Acetate | 1995 |
Role of tyrosine kinases in norepinephrine-induced contraction of vascular smooth muscle.
Topics: Animals; Aorta; Catechols; Enzyme Inhibitors; Genistein; GTP-Binding Proteins; Isoflavones; Male; Muscle Contraction; Muscle, Smooth, Vascular; Nitriles; Norepinephrine; Phorbol 12,13-Dibutyrate; Potassium Chloride; Protein-Tyrosine Kinases; Rats; Rats, Wistar; Sodium Fluoride; Tyrphostins; Vanadates | 1995 |
Peripheral vascular smooth muscle responsiveness to tumour-promoting phorbol esters in pacing-induced heart failure.
Topics: Animals; Blood Vessels; Disease Models, Animal; Dogs; Dose-Response Relationship, Drug; Heart Failure; Male; Muscle Contraction; Muscle, Smooth, Vascular; Phorbol 12,13-Dibutyrate; Phorbol Esters; Protein Kinase C; Time Factors | 1995 |
Role of protein kinase C in relationship between Ca2+ and contractile elements in rat alpha-toxin-permeabilized mesenteric artery.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Bacterial Toxins; Calcium; Cell Membrane Permeability; Enzyme Activation; Hemolysin Proteins; In Vitro Techniques; Isoquinolines; Male; Mesenteric Arteries; Muscle Contraction; Muscle, Smooth, Vascular; Phorbol 12,13-Dibutyrate; Piperazines; Protein Kinase C; Rats; Rats, Wistar; Signal Transduction; Staurosporine | 1995 |
Kinase activation and smooth muscle contraction in the presence and absence of calcium.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Alkaloids; Animals; Calcium; Carotid Arteries; Cattle; Dose-Response Relationship, Drug; Egtazic Acid; Enzyme Activation; In Vitro Techniques; Muscle Contraction; Muscle, Smooth, Vascular; Myosin-Light-Chain Kinase; Phorbol 12,13-Dibutyrate; Prostaglandin Endoperoxides, Synthetic; Protein Kinase C; Serotonin; Staurosporine; Thromboxane A2; Vasoconstrictor Agents | 1995 |
Role of protein kinase C in nonsensitized and passively sensitized human isolated bronchial smooth muscle.
Topics: Alkaloids; Allergens; Asthma; Bronchi; Dose-Response Relationship, Drug; Enzyme Activation; Humans; Immunization, Passive; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Phorbol 12,13-Dibutyrate; Phorbol Esters; Protein Kinase C; Staurosporine; Time Factors; Verapamil | 1995 |
Involvement of heterotrimeric GTP-binding protein and rho protein, but not protein kinase C, in agonist-induced Ca2+ sensitization of skinned muscle of guinea pig vas deferens.
Topics: Adenosine Diphosphate Ribose; ADP Ribose Transferases; Aluminum Compounds; Animals; Botulinum Toxins; Calcium; Escin; Fluorides; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Guinea Pigs; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Norepinephrine; Peptides; Phorbol 12,13-Dibutyrate; Protein Kinase C; rho GTP-Binding Proteins; Vas Deferens | 1995 |
EDTA and EGTA can discriminate tonic contractions induced by thromboxane A2 and phorbol ester in rabbit aortic smooth muscles.
Topics: Animals; Aorta; Edetic Acid; Egtazic Acid; Female; In Vitro Techniques; Magnesium; Male; Muscle Contraction; Muscle, Smooth, Vascular; Phorbol 12,13-Dibutyrate; Rabbits; Receptors, Thromboxane; Thromboxane A2; Time Factors | 1995 |
Inhibition of EGF-induced vasoconstriction in isolated rabbit aortic rings with the tyrosine kinase inhibitor RG50864.
Topics: Animals; Aorta, Abdominal; Catechols; Dose-Response Relationship, Drug; Epidermal Growth Factor; In Vitro Techniques; Kinetics; Male; Muscle Contraction; Muscle, Smooth, Vascular; Nitriles; Phorbol 12,13-Dibutyrate; Phosphoproteins; Phosphotyrosine; Protein-Tyrosine Kinases; Rabbits; Tyrosine; Tyrphostins; Vasoconstriction | 1993 |
Mechanical and biochemical responses to endothelin-1 and endothelin-3 in human bronchi.
Topics: Atropine; Bronchi; Calcium; Dose-Response Relationship, Drug; Endothelins; Glycopeptides; Humans; In Vitro Techniques; Indoles; Indomethacin; Inositol 1,4,5-Trisphosphate; Muscle Contraction; Muscle, Smooth; Nifedipine; Phorbol 12,13-Dibutyrate; Phosphorylation; Prostaglandin-Endoperoxide Synthases; Protease Inhibitors; Protein Kinase C | 1994 |
Mechanisms of the enhanced contractile response to a low concentration of phorbol 12,13-dibutyrate in thoracic aorta isolated from rats with dietary magnesium deficiency.
Topics: Animals; Aorta, Thoracic; Binding Sites; Calcium; Calcium Channels; Diet; Magnesium; Male; Muscle Contraction; Nifedipine; Phorbol 12,13-Dibutyrate; Protein Kinase C; Rats; Rats, Wistar | 1995 |
The involvement of protein kinase C in the contraction of human airway smooth muscle.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Bronchi; Histamine; Humans; In Vitro Techniques; Indoles; Isoquinolines; Maleimides; Muscle Contraction; Muscle, Smooth; Phorbol 12,13-Dibutyrate; Piperazines; Protein Kinase C; Staurosporine | 1995 |
Characteristics of relaxation induced by calcitonin gene-related peptide in contracted rabbit basilar artery.
Topics: Animals; Basilar Artery; Calcitonin Gene-Related Peptide; Male; Muscle Contraction; Muscle, Smooth, Vascular; Phorbol 12,13-Dibutyrate; Protein Kinase C; Rabbits; Vasoconstriction; Vasodilation | 1995 |
Adenosine analogues prevent phorbol ester-induced PKC depletion in porcine coronary artery via A1 receptor.
Topics: Adenine; Adenosine; Animals; Coronary Vessels; Dose-Response Relationship, Drug; Endothelins; Female; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; Norbornanes; Phenethylamines; Phorbol 12,13-Dibutyrate; Protein Kinase C; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Receptors, Purinergic P1; Receptors, Purinergic P2; Swine | 1995 |
Involvement of inositol 1,4,5-triphosphate and protein kinase C in thrombin-induced contraction of porcine pulmonary artery.
Topics: Alkaloids; Animals; Calcium; Drug Interactions; Endothelium, Vascular; In Vitro Techniques; Inositol 1,4,5-Trisphosphate; Muscle Contraction; Muscle, Smooth, Vascular; Phorbol 12,13-Dibutyrate; Potassium Chloride; Protein Kinase C; Pulmonary Artery; Staurosporine; Swine; Thrombin; Vasoconstriction; Verapamil | 1995 |
Phosphorylation of calponin mediated by protein kinase C in association with contraction in porcine coronary artery.
Topics: Animals; Calcium-Binding Proteins; Calponins; Chromatography, High Pressure Liquid; Coronary Vessels; Electrophoresis, Gel, Two-Dimensional; Endothelins; In Vitro Techniques; Kinetics; Microfilament Proteins; Muscle Contraction; Muscle Proteins; Muscle, Smooth, Vascular; Peptide Mapping; Phorbol 12,13-Dibutyrate; Phosphopeptides; Phosphorylation; Protein Kinase C; Swine | 1995 |
Cytochalasin inhibition of slow tension increase in rat aortic rings.
Topics: Alkaloids; Animals; Aorta, Thoracic; Cytochalasin B; Cytochalasins; Dose-Response Relationship, Drug; In Vitro Techniques; Kinetics; Male; Muscle Contraction; Muscle, Smooth, Vascular; Phorbol 12,13-Dibutyrate; Potassium Chloride; Protein Kinase C; Rats; Rats, Sprague-Dawley; Staurosporine; Temperature | 1994 |
Uncoupling of G-protein mediated fluoride contractions of vascular smooth muscle by pHi perturbations.
Topics: Animals; Aorta, Thoracic; Calcium; Coronary Vessels; Fluorides; GTP-Binding Proteins; Hydrogen-Ion Concentration; In Vitro Techniques; Muscle Contraction; Muscle, Smooth, Vascular; Nitroprusside; Phorbol 12,13-Dibutyrate; Protein Kinase C; Rabbits; Swine; Verapamil | 1994 |
Effect of a peptide inhibitor of protein kinase C on G-protein-mediated increase in myofilament Ca(2+)-sensitivity in rabbit arterial skinned muscle.
Topics: Actin Cytoskeleton; Animals; Binding Sites; Calcium; Escin; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); In Vitro Techniques; Male; Mesenteric Arteries; Muscle Contraction; Muscle, Smooth, Vascular; Myosins; Peptide Fragments; Phorbol 12,13-Dibutyrate; Phosphorylation; Protein Kinase C; Rabbits | 1994 |
Volatile anesthetics and agonist-induced contractions in porcine coronary artery smooth muscle and Ca2+ mobilization in cultured immortalized vascular smooth muscle cells.
Topics: Aluminum Compounds; Animals; Calcium; Cells, Cultured; Coronary Vessels; Dose-Response Relationship, Drug; Endothelins; Fluorides; Halothane; In Vitro Techniques; Isoflurane; Muscle Contraction; Muscle, Smooth, Vascular; Phorbol 12,13-Dibutyrate; Potassium Chloride; Protein Kinase C; Serotonin; Swine | 1994 |
Aging and chloride channel regulation in rat fast-twitch muscle fibres.
Topics: Aging; Animals; Calcimycin; Chloride Channels; Chlorides; Cholera Toxin; Colforsin; Electric Conductivity; Male; Muscle Contraction; Muscles; Phorbol 12,13-Dibutyrate; Potassium; Rats; Rats, Wistar; Time Factors; Toes; Virulence Factors, Bordetella | 1994 |
The effect of sodium transport and calcium channel inhibitors on phorbol ester-induced contraction of bovine airway smooth muscle.
Topics: Amiloride; Animals; Biological Transport; Bronchi; Calcium; Calcium Channel Blockers; Cattle; Drug Interactions; Edetic Acid; Furosemide; Glucose; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Peptides; Phorbol 12,13-Dibutyrate; Sodium; Sodium Channels; Tromethamine | 1993 |
Schistosoma mansoni: myogenic characteristics of phorbol ester-induced muscle contraction.
Topics: Acetylcholine; Animals; Cadmium; Calcimycin; Calcium; Calcium Channels; Carbachol; Cell Membrane Permeability; Dose-Response Relationship, Drug; Electromyography; Hydrogen-Ion Concentration; Male; Membrane Potentials; Microelectrodes; Muscle Contraction; Nicardipine; Phorbol 12,13-Dibutyrate; Praziquantel; Protein Kinase C; Schistosoma mansoni; Serotonin; Sodium; Tetradecanoylphorbol Acetate | 1994 |
Spatial changes of [Ca2+]i and contraction caused by phorbol esters in vascular smooth muscle cells.
Topics: Animals; Biological Transport; Calcium; Fluorescent Dyes; Fluorometry; Fura-2; Image Processing, Computer-Assisted; Intracellular Membranes; Muscle Contraction; Muscle, Smooth, Vascular; Osmolar Concentration; Phorbol 12,13-Dibutyrate; Phorbol Esters; Protein Kinase C | 1993 |
Inhibition of myosin light chain phosphatase during Ca(2+)-independent vasocontraction.
Topics: Animals; Aorta, Thoracic; Calcium; Colforsin; In Vitro Techniques; Kinetics; Male; Muscle Contraction; Muscle, Smooth, Vascular; Myosin-Light-Chain Phosphatase; Norepinephrine; Phorbol 12,13-Dibutyrate; Phorbols; Phosphates; Phosphoprotein Phosphatases; Phosphorus Radioisotopes; Rats; Rats, Wistar; Vasoconstriction; Vasodilator Agents | 1993 |
Tyrphostin attenuates platelet-derived growth factor-induced contraction in aortic smooth muscle through inhibition of protein tyrosine kinase(s).
Topics: Animals; Aorta, Thoracic; Catechols; Drug Synergism; Hypertension; In Vitro Techniques; Isometric Contraction; Kinetics; Male; Muscle Contraction; Muscle, Smooth, Vascular; Nitriles; Phenylephrine; Phorbol 12,13-Dibutyrate; Platelet-Derived Growth Factor; Protein-Tyrosine Kinases; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Tyrphostins | 1993 |
Effects of phorbol esters on contraction and protein kinase C activation in rabbit aorta.
Topics: Animals; Aorta, Thoracic; Enzyme Activation; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; Phorbol 12,13-Dibutyrate; Protein Kinase C; Rabbits; Tetradecanoylphorbol Acetate | 1994 |
Effect of vascular smooth muscle relaxants on the protein kinase C-mediated contraction in the rat pulmonary artery.
Topics: Animals; Enzyme Activation; Escin; In Vitro Techniques; Isometric Contraction; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Phorbol 12,13-Dibutyrate; Protein Kinase C; Pulmonary Artery; Rats; Rats, Wistar | 1993 |
Role of Na+ and protein kinase C in angiotensin desensitization and tachyphylaxis in the guinea-pig ileum.
Topics: Angiotensin II; Animals; Calcium; Cells, Cultured; Female; Guinea Pigs; Ileum; Male; Muscle Contraction; Phorbol 12,13-Dibutyrate; Protein Kinase C; Sodium; Tachyphylaxis | 1993 |
Protein kinase C isoforms in iris sphincter smooth muscle: differential effects of phorbol ester on contraction and cAMP accumulation are species specific.
Topics: Animals; Carcinogens; Cats; Cattle; Cell Membrane; Cyclic AMP; Cyclooxygenase Inhibitors; Cytosol; Dogs; Electrophoresis, Polyacrylamide Gel; Immunoblotting; Indomethacin; Iris; Isoenzymes; Muscle Contraction; Muscle, Smooth; Phorbol 12,13-Dibutyrate; Protein Kinase C; Rabbits; Species Specificity; Subcellular Fractions | 1996 |
Inhibitory effect of phorbol 12,13-dibutyrate on norepinephrine-induced contraction in rabbit iris dilator muscle.
Topics: Adrenergic alpha-Agonists; Animals; Calcium; Calcium Channel Blockers; Dose-Response Relationship, Drug; In Vitro Techniques; Isradipine; Male; Muscle Contraction; Muscle, Smooth; Norepinephrine; Oculomotor Muscles; Phorbol 12,13-Dibutyrate; Protein Kinase C; Rabbits | 1996 |
Activation of MAP kinases and phosphorylation of caldesmon in canine colonic smooth muscle.
Topics: Acetylcholine; Actins; Amino Acid Sequence; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Calmodulin-Binding Proteins; Colon; Dogs; Enzyme Activation; Female; In Vitro Techniques; Male; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Molecular Weight; Muscle Contraction; Muscle, Smooth; Neurokinin A; Oligopeptides; Phorbol 12,13-Dibutyrate; Phosphorylation; Substrate Specificity | 1996 |
Mechanisms in inhibitory action of aclarubicin on contractility of rat aorta.
Topics: Aclarubicin; Animals; Antibiotics, Antineoplastic; Aorta; Caffeine; Calcium; Calcium Radioisotopes; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; Phorbol 12,13-Dibutyrate; Phosphatidylinositols; Potassium Chloride; Rats; Rats, Wistar | 1995 |
Protein kinase C induced changes in human airway smooth muscle tone: the effects of Ca2+ and Na+ transport.
Topics: Amiloride; Bronchi; Calcium Channel Blockers; Dose-Response Relationship, Drug; Humans; Muscle Contraction; Muscle, Smooth; Nifedipine; Ouabain; Phorbol 12,13-Dibutyrate; Protein Kinase C; Sodium-Potassium-Exchanging ATPase; Verapamil | 1996 |
Activation of protein kinase C accelerates contraction kinetics of airway smooth muscle.
Topics: Animals; Electrophysiology; Enzyme Activation; In Vitro Techniques; Indoles; Kinetics; Lactams; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Phorbol 12,13-Dibutyrate; Potassium; Protein Kinase C; Rats; Rats, Wistar; Receptors, Muscarinic; Trachea; Verapamil; Vibration | 1996 |
Role of calcium in endothelin-induced contractions and prostacyclin release.
Topics: Animals; Aorta; Calcium; Calcium Channel Blockers; Diltiazem; Dose-Response Relationship, Drug; Endothelin-1; Epoprostenol; Male; Muscle Contraction; Phorbol 12,13-Dibutyrate; Protein Kinase C; Rats; Thapsigargin | 1996 |
Cyclosporine A-induced contractions and prostacyclin release are maintained by extracellular calcium in rat aortic rings: role of protein kinase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Aorta; Calcium Channel Blockers; Cell Membrane; Cyclosporine; Cytosol; Diltiazem; Enzyme Inhibitors; Epoprostenol; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; Phorbol 12,13-Dibutyrate; Protein Kinase C; Rats; Staurosporine; Thapsigargin | 1997 |
Dual roles of phorbol 12, 13-dibutyrate in the regulation of guinea-pig gastric contraction.
Topics: Animals; Calcium; Carbachol; Guinea Pigs; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Phorbol 12,13-Dibutyrate; Potassium; Protein Kinase C; Stomach | 1997 |
Cerebrovascular selectivity and vasospasmolytic action of the novel calcium antagonist (+/-)-(E)-1-(3-fluoro-6, 11-dihydrodibenz[b,e]oxepin-11-yl)-4-(3-phenyl-2-propenyl)-piperazine dimaleate in isolated cerebral arteries of the rabbit and dog.
Topics: Animals; Calcium Channel Blockers; Cerebral Arteries; Cerebrovascular Circulation; Dibenzoxepins; Dogs; Female; In Vitro Techniques; Ischemic Attack, Transient; Male; Muscle Contraction; Muscle, Smooth, Vascular; Phorbol 12,13-Dibutyrate; Piperazines; Potassium; Prostaglandins; Rabbits; Vasodilator Agents | 1997 |
Cyclic AMP and cyclic GMP relax phorbol ester-induced contractions of rat aorta by different mechanisms.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Aorta, Thoracic; Cyclic AMP; Cyclic GMP; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Myosin Light Chains; Phorbol 12,13-Dibutyrate; Phosphorylation; Protein Kinase C; Rats; Rats, Sprague-Dawley; Stimulation, Chemical | 1997 |
Protein kinase C mediates angiotensin II-induced contractions and the release of endothelin and prostacyclin in rat aortic rings.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Angiotensin II; Animals; Aorta, Thoracic; Dose-Response Relationship, Drug; Endothelin Receptor Antagonists; Endothelins; Enzyme Inhibitors; Epoprostenol; Male; Muscle Contraction; Muscle, Smooth, Vascular; Naphthalenes; Osmolar Concentration; Peptides, Cyclic; Phorbol 12,13-Dibutyrate; Protein Kinase C; Rats; Staurosporine; Vasoconstrictor Agents | 1997 |
Effects of phorbol ester on carbachol-induced contraction in bovine ciliary muscle: possible involvement of protein kinase C.
Topics: Animals; Carbachol; Cattle; Ciliary Body; Drug Interactions; Histones; In Vitro Techniques; Muscarinic Agonists; Muscle Contraction; Phorbol 12,13-Dibutyrate; Phosphorylation; Protein Kinase C; Receptors, Muscarinic; Stimulation, Chemical; Tetradecanoylphorbol Acetate | 1997 |
Inhibition by protein kinase C of the 86Rb+ efflux and vasorelaxation induced by P1075, a K(ATP) channel opener, in rat isolated aorta.
Topics: Adenosine Triphosphate; Animals; Aorta; Enzyme Activation; Enzyme Inhibitors; Guanidines; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Phorbol 12,13-Dibutyrate; Potassium Channels; Protein Binding; Protein Kinase C; Pyridines; Rats; Rats, Sprague-Dawley; Rubidium Radioisotopes; Tetradecanoylphorbol Acetate | 1997 |
Involvement of protein kinase C in the supersensitivity to 5-HT caused by oxidized low-density lipoproteins.
Topics: Acetylcholine; Animals; Aorta, Thoracic; Enzyme Inhibitors; In Vitro Techniques; Lipoproteins, LDL; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Phorbol 12,13-Dibutyrate; Potassium; Protein Kinase C; Rabbits; Serotonin; Staurosporine | 1997 |
Effects of phorbol-12,13-dibutyrate and protein kinase C inhibitors on Mn(2+)-dependent norepinephrine-induced contractions involving increase in Mn2+ sensitivity in Ca(2+)-depleted vas deferens of the guinea pig.
Topics: Animals; Calcium; Enzyme Inhibitors; Escin; Guanosine Triphosphate; Guinea Pigs; In Vitro Techniques; Indoles; Magnesium; Male; Maleimides; Muscle Contraction; Muscle, Smooth; Norepinephrine; Phorbol 12,13-Dibutyrate; Protein Kinase C; Staurosporine; Vas Deferens | 1997 |
Increased Ca2+ sensitivity of contractile elements via protein kinase C in alpha-toxin permeabilized SMA from young spontaneously hypertensive rats.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Analysis of Variance; Animals; Calcium; Enzyme Inhibitors; In Vitro Techniques; Male; Mesenteric Artery, Superior; Muscle Contraction; Muscle, Smooth, Vascular; Naphthalenes; Phorbol 12,13-Dibutyrate; Potassium; Protein Kinase C; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Signal Transduction; Staphylococcus aureus; Type C Phospholipases | 1997 |
Preferential inhibition by ethanol of phorbol ester-induced smooth muscle contraction of guinea pig gallbladder.
Topics: Animals; Barium Compounds; Calcimycin; Calcium; Central Nervous System Depressants; Chlorides; Drug Interactions; Enzyme Activation; Ethanol; Gallbladder; Guinea Pigs; In Vitro Techniques; Ionophores; Male; Muscle Contraction; Muscle, Smooth; Phorbol 12,13-Dibutyrate; Potassium Chloride; Protein Kinase C; Solutions; Stimulation, Chemical | 1998 |
Alpha1A-adrenoceptor mediated contraction of rat prostatic vas deferens and the involvement of ryanodine stores and Ca2+ influx stimulated by diacylglycerol and PKC.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Calcium; Diglycerides; In Vitro Techniques; Kinetics; Male; Muscle Contraction; Muscle, Smooth; Norepinephrine; Phorbol 12,13-Dibutyrate; Prazosin; Prostate; Protein Kinase C; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-1; Ryanodine; Stimulation, Chemical; Vas Deferens | 1998 |
Phorbol ester-induced contractions of mouse detrusor muscle are inhibited by nifedipine.
Topics: Animals; Calcium Channel Blockers; Enzyme Inhibitors; In Vitro Techniques; Male; Mice; Mice, Inbred ICR; Muscle Contraction; Muscle Tonus; Muscle, Smooth; Nifedipine; Phorbol 12,13-Dibutyrate; Protein Kinase C; Tetrodotoxin | 1998 |
A role of myofilament Ca2+ sensitivity in enhanced vascular reactivity in cardiomyopathic hamsters.
Topics: Actin Cytoskeleton; Angiotensin II; Animals; Aorta; Calcium; Calcium Channel Blockers; Cardiomyopathies; Cricetinae; Indoles; Male; Mesocricetus; Muscle Contraction; Muscle, Smooth, Vascular; Naphthalenes; Nifedipine; Phenylephrine; Phorbol 12,13-Dibutyrate; Potassium; Ryanodine; Staurosporine; Vasoconstrictor Agents | 1998 |
Chronic administration of taurine to aged rats improves the electrical and contractile properties of skeletal muscle fibers.
Topics: Aging; Animals; Calcium; Chloride Channels; Male; Membrane Potentials; Muscle Contraction; Muscle Fibers, Skeletal; Muscle, Skeletal; Phorbol 12,13-Dibutyrate; Rats; Rats, Wistar; Stereoisomerism; Taurine | 1998 |
Protein kinase C activation during Ca2+-independent vascular smooth muscle contraction.
Topics: Animals; Calcium; Calmodulin-Binding Proteins; Carcinogens; Carotid Arteries; Cattle; Cells, Cultured; Chelating Agents; Egtazic Acid; Enzyme Activation; Intracellular Signaling Peptides and Proteins; Isoenzymes; Membrane Proteins; Muscle Contraction; Muscle, Smooth, Vascular; Myosin Light Chains; Myristoylated Alanine-Rich C Kinase Substrate; Phorbol 12,13-Dibutyrate; Phosphorylation; Potassium Chloride; Protein Kinase C; Protein Kinase C-alpha; Protein Kinase C-epsilon; Proteins; Substrate Specificity; Vasoconstriction | 1998 |
Sodium hydrosulfite contractions of smooth muscle are calcium and myosin phosphorylation independent.
Topics: Alkaloids; Animals; Aorta, Thoracic; Benzophenanthridines; Caffeine; Calcium; Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone; In Vitro Techniques; Indoles; Muscle Contraction; Muscle, Smooth; Muscle, Smooth, Vascular; Myosins; Nisoldipine; Phenanthridines; Phorbol 12,13-Dibutyrate; Phosphorylation; Potassium Chloride; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Sulfites; Trachea | 1998 |
The effects of the Rho-kinase inhibitor Y-27632 on arachidonic acid-, GTPgammaS-, and phorbol ester-induced Ca2+-sensitization of smooth muscle.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Amides; Animals; Arachidonic Acid; Calcium; Enzyme Inhibitors; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; Models, Biological; Muscle Contraction; Muscle, Smooth, Vascular; Myosin Light Chains; Octoxynol; Permeability; Phorbol 12,13-Dibutyrate; Phosphorylation; Protein Serine-Threonine Kinases; Pulmonary Artery; Pyridines; Rabbits; rho-Associated Kinases; Type C Phospholipases | 1998 |
Desensitization of the histamine H1-receptor and transcriptional down-regulation of histamine H1-receptor gene expression in bovine tracheal smooth muscle.
Topics: Animals; Blotting, Northern; Cattle; Dose-Response Relationship, Drug; Down-Regulation; Enzyme Activation; Enzyme Inhibitors; Gene Expression Regulation; Histamine; In Vitro Techniques; Indoles; Inositol Phosphates; Maleimides; Muscle Contraction; Muscle, Smooth; Phorbol 12,13-Dibutyrate; Protein Kinase C; Receptors, Histamine H1; Sodium Fluoride; Trachea; Transcription, Genetic; Tritium | 1998 |
Tyrosine phosphorylation as a convergent pathway of heterotrimeric G protein- and rho protein-mediated Ca2+ sensitization of smooth muscle of rabbit mesenteric artery.
Topics: Adenosine Diphosphate; ADP Ribose Transferases; Animals; Botulinum Toxins; Calcium; Carcinogens; Dimerization; Dose-Response Relationship, Drug; Enzyme Inhibitors; Genistein; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Histamine; In Vitro Techniques; Male; Mesenteric Arteries; Muscle Contraction; Muscle, Smooth; Naphthalenes; Phenylephrine; Phorbol 12,13-Dibutyrate; Phosphorylation; Protein Kinase C; Protein-Tyrosine Kinases; Rabbits; rho GTP-Binding Proteins; Ribose; Staurosporine; Tyrosine; Tyrphostins; Vasoconstrictor Agents | 1998 |
Effects of phorbol esters on excitation-contraction coupling and protein kinase C activity of frog twitch muscle fibers.
Topics: Alkaloids; Animals; Anti-Bacterial Agents; Benzophenanthridines; Calcium Signaling; Cold Temperature; Down-Regulation; Enzyme Inhibitors; In Vitro Techniques; Muscle Contraction; Muscle Fibers, Skeletal; Okadaic Acid; Patch-Clamp Techniques; Phenanthridines; Phorbol 12,13-Dibutyrate; Polymyxin B; Protein Kinase C; Ranidae | 1999 |
Bradykinin and phorbol ester but not 5-HT2B receptor activation stimulate phospholipase D activity in the rat stomach fundus.
Topics: Animals; Bradykinin; Calcium; Enzyme Activation; Gastric Fundus; Glycerophospholipids; In Vitro Techniques; Kinetics; Male; Muscle Contraction; Muscle, Smooth; Phorbol 12,13-Dibutyrate; Phospholipase D; Protein Kinase C; Rats; Rats, Wistar; Receptor, Serotonin, 5-HT2B; Receptors, Serotonin; Serotonin; Signal Transduction; Stomach | 1999 |
Reconstitution of protein kinase C-induced contractile Ca2+ sensitization in triton X-100-demembranated rabbit arterial smooth muscle.
Topics: Animals; Blotting, Western; Calcium; Cell Membrane; Enzyme Activators; In Vitro Techniques; Isoenzymes; Male; Muscle Contraction; Muscle, Smooth, Vascular; Octoxynol; Phorbol 12,13-Dibutyrate; Phosphorylation; Protein Kinase C; Rabbits; Recombinant Proteins | 1999 |
An unusual Ca(2+) entry pathway activated by protein kinase C in dog splenic artery.
Topics: Animals; Calcium; Cations; Dogs; Dose-Response Relationship, Drug; Drug Interactions; Egtazic Acid; Female; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; Nifedipine; Norepinephrine; Perfusion; Phorbol 12,13-Dibutyrate; Protein Kinase C; Splenic Artery; Time Factors | 1999 |
[Differences in phorbol-dependent phosphorylation of regulatory proteins and contraction of phasic and tonic smooth muscle].
Topics: Amino Acid Sequence; Animals; Calcium-Binding Proteins; Calmodulin-Binding Proteins; Chickens; In Vitro Techniques; Kinesins; Mitogen-Activated Protein Kinases; Molecular Sequence Data; Muscle Contraction; Muscle Proteins; Muscle, Smooth; Myosin-Light-Chain Kinase; Peptide Mapping; Phorbol 12,13-Dibutyrate; Phosphorylation; Rats | 2000 |
Gender-related distinctions in protein kinase C activity in rat vascular smooth muscle.
Topics: Animals; Estrogens; Female; Male; Models, Animal; Muscle Contraction; Muscle, Smooth, Vascular; Orchiectomy; Ovariectomy; Phenylephrine; Phorbol 12,13-Dibutyrate; Protein Isoforms; Protein Kinase C; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptors, Estrogen; Sex Factors | 2001 |
HNS-32, a novel azulene-1-carboxamidine derivative, inhibits nifedipine-sensitive and -insensitive contraction of the isolated rabbit aorta.
Topics: Animals; Anti-Arrhythmia Agents; Aorta, Thoracic; Calcium Channel Blockers; Colforsin; Endothelium, Vascular; Enzyme Activation; In Vitro Techniques; Male; Membrane Potentials; Muscle Contraction; Muscle, Smooth, Vascular; Nifedipine; Nitroglycerin; Norepinephrine; Phorbol 12,13-Dibutyrate; Potassium Channel Blockers; Potassium Chloride; Protein Kinase C; Pyridines; Rabbits; Tetraethylammonium; Vasoconstrictor Agents; Vasodilator Agents | 2001 |
[Absence of detubulation in frog twitch muscle fibres exposed to protein kinase C activator].
Topics: Action Potentials; Animals; Enzyme Activators; Muscle Contraction; Muscle Fibers, Skeletal; Muscle, Skeletal; Phorbol 12,13-Dibutyrate; Protein Kinase C; Ranidae | 1998 |
Remodeling of the actin cytoskeleton in the contracting A7r5 smooth muscle cell.
Topics: Actins; Animals; Aorta; Carcinogens; Cell Size; Cells, Cultured; Cytoskeleton; Embryo, Mammalian; Muscle Contraction; Muscle, Smooth; Phorbol 12,13-Dibutyrate; Rats | 2000 |
Histamine-induced vasoconstriction involves phosphorylation of a specific inhibitor protein for myosin phosphatase by protein kinase C alpha and delta isoforms.
Topics: Amides; Amino Acid Sequence; Animals; Aorta; Carbazoles; Chromatography; Chromatography, Affinity; Chromatography, Ion Exchange; Durapatite; Enzyme Activation; Enzyme Inhibitors; Histamine; In Vitro Techniques; Indoles; Isoenzymes; Kinetics; Maleimides; Molecular Sequence Data; Muscle Contraction; Muscle Proteins; Muscle Relaxants, Central; Muscle, Smooth, Vascular; Myelin Basic Protein; Myosin-Light-Chain Phosphatase; Peptide Fragments; Phorbol 12,13-Dibutyrate; Phosphoprotein Phosphatases; Phosphoproteins; Phosphorylation; Protein Kinase C; Protein Kinase C-alpha; Protein Kinase C-delta; Pyridines; Recombinant Proteins; Substrate Specificity; Swine; Vasoconstriction | 2001 |
Hydroxyfasudil, an active metabolite of fasudil hydrochloride, relaxes the rabbit basilar artery by disinhibition of myosin light chain phosphatase.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Animals; Basilar Artery; Calcium; Endothelin-1; Enzyme Activation; Guanosine 5'-O-(3-Thiotriphosphate); Kinetics; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Myosin-Light-Chain Phosphatase; Phorbol 12,13-Dibutyrate; Phosphoprotein Phosphatases; Protein Kinase C; Rabbits; Vasodilator Agents | 2001 |
Expression of CPI-17 and myosin phosphatase correlates with Ca(2+) sensitivity of protein kinase C-induced contraction in rabbit smooth muscle.
Topics: Actins; Animals; Aorta; Calcium; Calcium-Binding Proteins; Calponins; Carcinogens; Femoral Artery; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Immunohistochemistry; Male; Microfilament Proteins; Muscle Contraction; Muscle Proteins; Muscle, Smooth, Vascular; Myosin Light Chains; Myosin-Light-Chain Phosphatase; Phorbol 12,13-Dibutyrate; Phosphoprotein Phosphatases; Phosphoproteins; Phosphorylation; Portal Vein; Protein Kinase C; Rabbits; Trachea; Urinary Bladder; Vas Deferens | 2001 |
PI3-kinase/Akt modulates vascular smooth muscle tone via cAMP signaling pathways.
Topics: Animals; Carotid Arteries; Cattle; Chromones; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Enzyme Activators; Female; Heat-Shock Proteins; Isoelectric Focusing; Morpholines; Muscle Contraction; Muscle, Smooth, Vascular; Myosin-Light-Chain Kinase; Oxygen Consumption; Phorbol 12,13-Dibutyrate; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Pregnancy; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Signal Transduction | 2001 |
Intracellular alkalinization augments alpha(1)-adrenoceptor-mediated vasoconstriction by promotion of Ca(2+) entry through the non-L-type Ca(2+) channels.
Topics: Adrenergic alpha-Agonists; Ammonium Chloride; Animals; Aorta; Calcium; Calcium Channel Blockers; Calcium Channels, L-Type; Clonidine; Dose-Response Relationship, Drug; Drug Synergism; Guinea Pigs; Hydrogen-Ion Concentration; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; Norepinephrine; Phenylephrine; Phorbol 12,13-Dibutyrate; Potassium Chloride; Propionates; Receptors, Adrenergic, alpha-1; Vasoconstriction; Verapamil | 2001 |
Acidosis inhibits gallbladder contraction mediated by protein kinase C activation.
Topics: Acidosis; Animals; Calcium; Calcium Chloride; Dinoprostone; Enzyme Activation; Extracellular Space; Gallbladder; Guinea Pigs; HEPES; Histamine; Hydrogen-Ion Concentration; In Vitro Techniques; Male; Muscle Contraction; Phorbol 12,13-Dibutyrate; Potassium Chloride; Protein Kinase C; Staurosporine | 2001 |
ERK MAP kinases regulate smooth muscle contraction in ovine uterine artery: effect of pregnancy.
Topics: Animals; Arteries; Enzyme Inhibitors; Female; Flavonoids; In Vitro Techniques; Mitogen-Activated Protein Kinases; Muscle Contraction; Muscle, Smooth, Vascular; Phenylephrine; Phorbol 12,13-Dibutyrate; Potassium Chloride; Pregnancy; Pregnancy, Animal; Sheep; Uterus | 2002 |
Diminished inibitory action of ethanol on the contraction of gallbladder isolated from chronically ethanol-fed Guinea pigs.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Body Weight; Calcium Channel Agonists; Dose-Response Relationship, Drug; Ethanol; Gallbladder; Guinea Pigs; Histamine; In Vitro Techniques; Male; Muscle Contraction; Phorbol 12,13-Dibutyrate; Potassium Chloride; Verapamil | 2002 |
Phosphorylation of kinase-related protein (telokin) in tonic and phasic smooth muscles.
Topics: Animals; Carotid Arteries; Chickens; Colforsin; Culture Techniques; Gizzard, Avian; Isometric Contraction; Muscle Contraction; Muscle Proteins; Muscle Relaxation; Muscle, Smooth, Vascular; Myosin-Light-Chain Kinase; Peptide Fragments; Peptide Mapping; Peptides; Phorbol 12,13-Dibutyrate; Phosphorylation; Potassium Chloride; Time Factors | 2001 |
Protein kinase C modulators enhance angiotensin II desensitization of guinea pig ileum via maxi-K+ channels.
Topics: Alkaloids; Angiotensin II; Animals; Benzophenanthridines; Enzyme Activation; Enzyme Inhibitors; Female; Guinea Pigs; Ileum; In Vitro Techniques; Large-Conductance Calcium-Activated Potassium Channels; Male; Membrane Potentials; Muscle Contraction; Muscle, Smooth; Phenanthridines; Phorbol 12,13-Dibutyrate; Potassium Channels, Calcium-Activated; Potassium Chloride; Protein Kinase C; Vasoconstrictor Agents | 2002 |
Prolonged activation of alpha 1 adrenoceptors induces down-regulation of protein kinase C in vascular smooth muscle.
Topics: Animals; Aorta, Thoracic; Binding, Competitive; Blotting, Western; Down-Regulation; In Vitro Techniques; Male; Muscle Contraction; Muscle Proteins; Muscle, Smooth, Vascular; Norepinephrine; Phorbol 12,13-Dibutyrate; Phorbol Esters; Protein Kinase C; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha | 1992 |
A pertussis toxin-sensitive mechanism of endothelin action in porcine coronary artery smooth muscle.
Topics: Adenosine Diphosphate Ribose; Animals; Arteries; Calcium; Calcium Channels; Coronary Vessels; Dose-Response Relationship, Drug; Endothelins; GTP-Binding Proteins; In Vitro Techniques; Inositol Phosphates; Muscle Contraction; Muscle, Smooth, Vascular; Nifedipine; Pertussis Toxin; Phorbol 12,13-Dibutyrate; Swine; Virulence Factors, Bordetella | 1992 |
Comparative studies on the mode of action of proctolin and phorbol-12,13-dibutyrate in their ability to contract the locust mandibular closer muscle.
Topics: Amino Acid Sequence; Animals; Calcium; Cyclic AMP; Female; Grasshoppers; Male; Mandible; Molecular Sequence Data; Muscle Contraction; Muscles; Neuropeptides; Neurotransmitter Agents; Oligopeptides; Phorbol 12,13-Dibutyrate; Protein Kinase Inhibitors | 1992 |
Activation of protein kinase C isozymes by contractile stimuli in arterial smooth muscle.
Topics: Animals; Cell Compartmentation; Cytosol; Enzyme Activation; Histamine; In Vitro Techniques; Isoenzymes; Membrane Potentials; Muscle Contraction; Muscle, Smooth, Vascular; Phorbol 12,13-Dibutyrate; Prazosin; Protein Kinase C; Swine; Time Factors; Vasoconstriction | 1992 |
Effects of phorbol ester on lower urinary tract smooth muscles in rabbits.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Carbachol; Drug Interactions; Female; Isoquinolines; Muscle Contraction; Muscle, Smooth; Phenylephrine; Phorbol 12,13-Dibutyrate; Piperazines; Potassium Chloride; Protein Kinase Inhibitors; Rabbits; Urethra; Urinary Bladder | 1992 |
Calcium ion-independent contraction of bladder smooth muscle.
Topics: Animals; Caffeine; Calcium; Carbachol; Humans; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Phorbol 12,13-Dibutyrate; Rabbits; Urinary Bladder | 1992 |
Protein phosphorylation in arterial muscle contracted by high concentration of phorbol dibutyrate in the presence and absence of Ca2+.
Topics: Animals; Calcium; Calmodulin-Binding Proteins; Chromatography; Desmin; Electrophoresis; Hydrogen-Ion Concentration; In Vitro Techniques; Muscle Contraction; Muscle Proteins; Muscle, Smooth, Vascular; Myosins; Peptide Mapping; Phorbol 12,13-Dibutyrate; Phosphorylation; Swine | 1992 |
Vascular protein kinase C in Wistar-Kyoto and spontaneously hypertensive rats.
Topics: Animals; Caenorhabditis elegans Proteins; Carrier Proteins; Hypertension; Muscle Contraction; Muscle, Smooth, Vascular; Phorbol 12,13-Dibutyrate; Protein Kinase C; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptors, Drug | 1992 |
Is protein kinase C involved in histamine H1-receptor desensitization?
Topics: Animals; Cyclic GMP; Drug Tolerance; Guinea Pigs; Histamine; Ionomycin; Jejunum; Kinetics; Lung; Male; Methacholine Chloride; Muscle Contraction; Phorbol 12,13-Dibutyrate; Protein Kinase C; Receptors, Histamine H1 | 1991 |
Effect of extracellular Ca2+ on cholinergic, KCl and phorbol ester-mediated phosphoinositide turnover and guinea pig urinary bladder contraction.
Topics: Animals; Calcium; Carbachol; Enzyme Activation; Guinea Pigs; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Phorbol 12,13-Dibutyrate; Phorbol Esters; Phosphatidylinositols; Potassium Chloride; Protein Kinase C; Receptors, Muscarinic; Urinary Bladder | 1991 |
Protein kinase C-mediated contraction in rabbit aorta is inhibited by CD-349, a dihydropyridine derivative.
Topics: Animals; Aorta, Thoracic; Atrial Natriuretic Factor; Calcium Channel Blockers; Cyclic AMP; Dihydropyridines; Endothelins; Male; Muscle Contraction; Nitroglycerin; Phorbol 12,13-Dibutyrate; Protein Kinase C; Rabbits | 1991 |
Contraction of vascular smooth muscle induced by phorbol 12,13 dibutyrate in human and rat pulmonary arteries.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Atropine; Calcium; Humans; In Vitro Techniques; Isometric Contraction; Muscle Contraction; Muscle Tonus; Muscle, Smooth, Vascular; Phentolamine; Phorbol 12,13-Dibutyrate; Potassium; Propranolol; Protein Kinase C; Pulmonary Artery; Rats; Tetrodotoxin; Trifluoperazine; Verapamil | 1991 |
Evidence for protein kinase C modulation of the ciliary muscle response to carbachol and desensitization.
Topics: Alkaloids; Animals; Carbachol; Cattle; Ciliary Body; Diglycerides; Dinoprost; Enzyme Activation; Muscarinic Antagonists; Muscle Contraction; Muscle, Smooth; Phorbol 12,13-Dibutyrate; Phorbol Esters; Protein Kinase C; Staurosporine; Substance P | 1991 |
Protein kinase C and phospholipase C in adenosine receptor-mediated relaxation in coronary artery.
Topics: 2-Chloroadenosine; Adenosine; Adenosine-5'-(N-ethylcarboxamide); Alkaloids; Animals; Coronary Vessels; Isoproterenol; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Nitroprusside; Phorbol 12,13-Dibutyrate; Potassium Chloride; Protein Kinase C; Receptors, Purinergic; Staurosporine; Swine; Type C Phospholipases | 1991 |
Is staurosporine a specific inhibitor of protein kinase C in intact porcine coronary arteries?
Topics: Alkaloids; Animals; Calcium; Coronary Vessels; Enzyme Activation; In Vitro Techniques; Kinetics; Muscle Contraction; Muscle, Smooth, Vascular; Phorbol 12,13-Dibutyrate; Potassium Chloride; Protein Kinase C; Staurosporine; Substrate Specificity; Swine; Time Factors | 1991 |
Comparison of adenosine receptor agonists with other vasodilators on noradrenaline-, potassium- and phorbol ester-contracted rabbit aorta.
Topics: Animals; Aorta; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Norepinephrine; Phorbol 12,13-Dibutyrate; Potassium Chloride; Rabbits; Receptors, Purinergic; Vasodilator Agents | 1991 |
Contraction of rat thoracic aorta strips by endothelin-1 in the absence of extracellular Ca2+.
Topics: Animals; Aorta, Thoracic; Caffeine; Calcium; Endothelins; In Vitro Techniques; Indicators and Reagents; Male; Marine Toxins; Muscle Contraction; Muscle, Smooth, Vascular; Norepinephrine; Oxazoles; Phorbol 12,13-Dibutyrate; Rats; Rats, Inbred Strains; Tetradecanoylphorbol Acetate; Urotensins; Vasoconstrictor Agents | 1991 |
Endothelin-1-induced phosphorylation of the 20-kDa myosin light chain and caldesmon in porcine coronary artery smooth muscle.
Topics: Animals; Calcium; Calmodulin; Calmodulin-Binding Proteins; Coronary Vessels; Endothelins; In Vitro Techniques; Kinetics; Muscle Contraction; Muscle, Smooth, Vascular; Myosins; Nitroglycerin; Phorbol 12,13-Dibutyrate; Phosphorylation; Swine; Time Factors | 1991 |
A selective effect of protein kinase C activators on noradrenaline release compared with subsequent contraction in canine isolated saphenous veins.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Diterpenes; Dogs; Electric Stimulation; Enzyme Activation; Female; In Vitro Techniques; Isoquinolines; Male; Muscle Contraction; Muscle, Smooth, Vascular; Norepinephrine; Phorbol 12,13-Dibutyrate; Piperazines; Polymyxin B; Protein Kinase C; Saphenous Vein; Terpenes | 1991 |
Enhanced contractile effect of phorbol dibutyrate in portal veins from hypertensive rats.
Topics: Alkaloids; Animals; Dose-Response Relationship, Drug; Egtazic Acid; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; Nifedipine; Phorbol 12,13-Dibutyrate; Portal Vein; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Staurosporine | 1991 |
Protein kinase C translocation in rat stomach fundus: effects of serotonin, carbamylcholine and phorbol dibutyrate.
Topics: Alkaloids; Animals; Carbachol; Gastric Fundus; Male; Muscle Contraction; Muscle, Smooth; Phorbol 12,13-Dibutyrate; Protein Kinase C; Rats; Rats, Inbred Strains; Serotonin; Staurosporine | 1991 |
Modification of myosin light chain phosphorylation in sustained arterial muscle contraction by phorbol dibutyrate.
Topics: Animals; Arteries; Electrophoresis, Gel, Two-Dimensional; Muscle Contraction; Muscle, Smooth, Vascular; Myosin-Light-Chain Kinase; Phorbol 12,13-Dibutyrate; Phosphorylation; Potassium; Swine | 1991 |
5-hydroxytryptamine-stimulated accumulation of 1,2-diacylglycerol in the rabbit basilar artery: a role for protein kinase C in smooth muscle contraction.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Diglycerides; Female; In Vitro Techniques; Inositol Phosphates; Isoquinolines; Male; Muscle Contraction; Muscle, Smooth, Vascular; Phorbol 12,13-Dibutyrate; Piperazines; Protein Kinase C; Rabbits; Serotonin | 1991 |
A synthetic pseudosubstrate peptide of protein kinase C inhibits the phorbol-12,13-dibutyrate effect on permeabilized coronary artery smooth muscle.
Topics: Animals; Capillary Permeability; Coronary Vessels; Detergents; Kinetics; Muscle Contraction; Muscle, Smooth, Vascular; Peptide Fragments; Phorbol 12,13-Dibutyrate; Protein Kinase C; Swine | 1991 |
[Loss of contractile stability induced by phenylephrine and endothelin in the aorta of rats treated with endotoxin].
Topics: Animals; Aorta, Thoracic; Endothelins; Endothelium, Vascular; Endotoxins; Male; Muscle Contraction; Muscle, Smooth, Vascular; Phenylephrine; Phorbol 12,13-Dibutyrate; Potassium Chloride; Rats; Rats, Inbred Strains; Shock, Septic | 1990 |
Atrial peptides inhibit protein kinase C-mediated contraction in rat aorta.
Topics: Animals; Aorta, Thoracic; Atrial Natriuretic Factor; Cytosol; Hypertension; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; Phorbol 12,13-Dibutyrate; Protein Kinase C; Rats; Rats, Inbred SHR; Rats, Inbred WKY | 1990 |
Long-term treatment of isolated rat soleus muscle with phorbol ester leads to loss of contraction-induced glucose transport.
Topics: Animals; Biological Transport; Female; Glucose; Glycogen; In Vitro Techniques; Insulin; Muscle Contraction; Muscles; Phorbol 12,13-Dibutyrate; Protein Kinase C; Rats; Rats, Inbred Strains; Tetradecanoylphorbol Acetate | 1990 |
Phorbol ester-induced stress and myosin light chain phosphorylation in swine carotid medial smooth muscle.
Topics: Alkaloids; Animals; Calcium; Drug Interactions; Enzyme Activation; Histamine; In Vitro Techniques; Muscle Contraction; Muscle, Smooth, Vascular; Myosin-Light-Chain Kinase; Nifedipine; Phorbol 12,13-Dibutyrate; Phosphorylation; Protein Kinase C; Staurosporine; Swine | 1990 |
[3H]5-hydroxytryptamine uptake and release in cat cerebral arteries.
Topics: Animals; Azepines; Cats; Cerebral Arteries; Cocaine; Electric Stimulation; Female; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; Norepinephrine; Ouabain; Phentolamine; Phorbol 12,13-Dibutyrate; Protein Kinase C; Serotonin; Sympathectomy, Chemical; Tetrodotoxin | 1990 |
Analysis of myosin light chain phosphopeptides in phorbol dibutyrate-contracted artery.
Topics: Animals; Muscle Contraction; Muscle, Smooth, Vascular; Myosin-Light-Chain Kinase; Peptide Mapping; Phorbol 12,13-Dibutyrate; Phosphopeptides; Phosphorylation; Potassium; Protein Kinase C; Swine | 1990 |
Contrasting effects of phorbol dibutyrate and phorbol myristate acetate in rabbit aorta.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Aorta; Cells, Cultured; Epinephrine; In Vitro Techniques; Isoquinolines; Liver; Muscle Contraction; Muscle, Smooth, Vascular; Phorbol 12,13-Dibutyrate; Phosphates; Phosphatidylinositols; Piperazines; Protein Kinase Inhibitors; Rabbits; Tetradecanoylphorbol Acetate | 1990 |
Increased reactivity in the mesenteric artery of spontaneously hypertensive rats to phorbol ester.
Topics: Animals; Carcinogens; In Vitro Techniques; Ion Channels; Male; Mesenteric Arteries; Muscle Contraction; Muscle, Smooth, Vascular; Phorbol 12,13-Dibutyrate; Phorbol Esters; Rats; Rats, Inbred SHR; Rats, Inbred WKY | 1987 |
Effects of a phorbol ester on rat aortic contraction and calcium influx in the presence and absence of BAY k 8644.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Aorta; Calcium; Calcium Channel Agonists; Drug Interactions; In Vitro Techniques; Ion Channels; Muscle Contraction; Muscle, Smooth, Vascular; Nitrendipine; Phorbol 12,13-Dibutyrate; Phorbol Esters; Protein Kinase C; Rats | 1987 |
Interactions between phorbol esters and agents which increase cytosolic calcium in the guinea pig parenchymal strip: direct and indirect effects on the contractile response.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcimycin; Calcium; Cytosol; Dose-Response Relationship, Drug; Guinea Pigs; In Vitro Techniques; Lung; Male; Muscle Contraction; Phorbol 12,13-Dibutyrate; Protein Kinase C; Tetradecanoylphorbol Acetate; Vanadates | 1988 |
Dependence of stress on cross-bridge phosphorylation in vascular smooth muscle.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcium; Calcium Channels; Ethers; Histamine; Ionomycin; Kinetics; Muscle Contraction; Muscle, Smooth, Vascular; Myosins; Phorbol 12,13-Dibutyrate; Phosphoproteins; Potassium; Swine | 1989 |
The effect of smooth muscle relaxants working through different transduction mechanisms on the phorbol dibutyrate-induced contraction of the guinea-pig lung parenchymal strip: possible relevance for asthma.
Topics: Animals; Asthma; Enzyme Activation; Guinea Pigs; Histamine; In Vitro Techniques; Ion Channels; Lung; Male; Muscle Contraction; Muscle Relaxants, Central; Muscle Relaxation; Muscle, Smooth; Phorbol 12,13-Dibutyrate; Protein Kinase C; Receptors, Drug; Signal Transduction | 1989 |
Phorbol dibutyrate inhibits release and action of endothelium-derived relaxing factor(s) in canine blood vessels.
Topics: Acetylcholine; Animals; Biological Factors; Calcimycin; Coronary Vessels; Dogs; Femoral Artery; In Vitro Techniques; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Nitric Oxide; Nitroprusside; Phorbol 12,13-Dibutyrate | 1989 |
Role of monokines in altering receptor and non-receptor mediated vascular contraction in sepsis.
Topics: Acetylcholine; Animals; Aorta, Thoracic; Endothelium, Vascular; In Vitro Techniques; Indomethacin; Inositol Phosphates; Interleukin-1; Male; Muscle Contraction; Muscle, Smooth, Vascular; Norepinephrine; Phorbol 12,13-Dibutyrate; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Recombinant Proteins; Reference Values; Second Messenger Systems; Shock, Septic; Tumor Necrosis Factor-alpha; Vasoconstriction; Vasopressins | 1989 |
Monocyte-derived interleukin 1: effects on norepinephrine-stimulated aortic contraction and phosphoinositide turnover.
Topics: Acetylcholine; Animals; Antibodies; Aorta; Cells, Cultured; Culture Media; Humans; Hydrolysis; Interleukin-1; Male; Monocytes; Muscle Contraction; Muscle, Smooth, Vascular; Norepinephrine; Phorbol 12,13-Dibutyrate; Phosphatidylinositols; Rats; Rats, Inbred Strains | 1989 |
Direct regulation of smooth muscle contractile elements by second messengers.
Topics: Animals; Calcium; Colforsin; Cyclic AMP; Cyclic GMP; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Phorbol 12,13-Dibutyrate; Rats; Rats, Inbred WKY; Second Messenger Systems | 1989 |
Protein kinase C regulates the tonic but not the phasic component of contraction in guinea-pig ileum.
Topics: Animals; Carbachol; Down-Regulation; Female; Guinea Pigs; Ileum; In Vitro Techniques; Inositol Phosphates; Male; Muscle Contraction; Muscle, Smooth; Phorbol 12,13-Dibutyrate; Potassium; Protein Kinase C | 1989 |
Phosphorylation of smooth muscle myosin heavy and light chains. Effects of phorbol dibutyrate and agonists.
Topics: Animals; Carbachol; Cattle; Cells, Cultured; Electrophoresis, Gel, Two-Dimensional; In Vitro Techniques; Isoproterenol; Kinetics; Muscle Contraction; Muscle, Smooth; Myosin Subfragments; Peptide Mapping; Phorbol 12,13-Dibutyrate; Phosphopeptides; Phosphorylation; Trachea | 1989 |
Phorbol ester effects on coupling mechanisms during cholinergic contraction of swine tracheal smooth muscle.
Topics: Amiloride; Animals; Carbachol; In Vitro Techniques; Inositol Phosphates; Membrane Potentials; Muscle Contraction; Muscle, Smooth; Phorbol 12,13-Dibutyrate; Swine; Trachea; Verapamil | 1989 |
Comparative effects of endothelin and phorbol 12-13 dibutyrate in rat aorta.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Aorta; Calcium; Diltiazem; Endothelins; Endothelium, Vascular; Isoquinolines; Male; Muscle Contraction; Muscle, Smooth, Vascular; Peptides; Phenylephrine; Phloretin; Phorbol 12,13-Dibutyrate; Piperazines; Protein Kinase C; Rats; Rats, Inbred Strains; Staurosporine; Vasoconstriction | 1989 |
The effect of relaxants working through different transduction mechanisms on the tonic contraction produced in rat aorta by 4 beta-phorbol dibutyrate.
Topics: Animals; Aorta, Thoracic; Benzopyrans; Colforsin; Cromakalim; In Vitro Techniques; Isoproterenol; Male; Methoxamine; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Nitroprusside; Parasympatholytics; Phorbol 12,13-Dibutyrate; Pyrroles; Rats; Rats, Inbred Strains; Xanthines | 1989 |
Alterations in bidirectional transmembrane calcium flux occur without changes in protein kinase C levels in rat aorta during sepsis.
Topics: Animals; Aorta; Binding Sites; Calcium; Cell Membrane; Male; Muscle Contraction; Norepinephrine; Phorbol 12,13-Dibutyrate; Phorbol Esters; Protein Kinase C; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Sarcoplasmic Reticulum; Sepsis; Time Factors | 1988 |
Correlative studies on the effect of carbachol on myo-inositol trisphosphate accumulation, myosin light chain phosphorylation and contraction in sphincter smooth muscle of rabbit iris.
Topics: Animals; Atropine; Calcium; Carbachol; Ethers; Female; Inositol 1,4,5-Trisphosphate; Inositol Phosphates; Ionomycin; Iris; Male; Membranes; Muscle Contraction; Muscle, Smooth; Myosins; Phorbol 12,13-Dibutyrate; Phorbol Esters; Phosphatidylinositol Phosphates; Phosphatidylinositols; Phosphorylation; Rabbits; Sugar Phosphates; Temperature; Time Factors | 1986 |
Phorbol dibutyrate contractions in rabbit aorta: calcium dependence and sensitivity to nitrovasodilators and 8-BR-cyclic GMP.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Calcium; Male; Muscle Contraction; Nifedipine; Nitroglycerin; Nitroprusside; Norepinephrine; Phorbol 12,13-Dibutyrate; Phorbol Esters; Potassium Chloride; Rabbits; Time Factors; Vasodilation; Verapamil | 1986 |
Dissociation of myosin phosphorylation and active tension during muscarinic stimulation of tracheal smooth muscle.
Topics: Atropine; Calcium; Calcium Chloride; Carbachol; Dose-Response Relationship, Drug; Egtazic Acid; Muscle Contraction; Muscle, Smooth; Myosins; Nifedipine; Phorbol 12,13-Dibutyrate; Phorbol Esters; Phosphorylation; Potassium; Serotonin; Tetradecanoylphorbol Acetate; Trachea | 1987 |
Protein kinase C activity and reactivity to phorbol ester in vascular smooth muscle from spontaneously hypertensive rats (SHR) and normotensive Wistar Kyoto rats (WKY).
Topics: Animals; Aorta; Isometric Contraction; Kinetics; Male; Muscle Contraction; Muscle, Smooth, Vascular; Phorbol 12,13-Dibutyrate; Phorbol Esters; Protein Kinase C; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Reference Values; Renal Artery; Species Specificity | 1988 |
Phorbol 12,13-dibutyrate, an activator of protein kinase C, stimulates both contraction and Ca2+ fluxes in dog saphenous vein.
Topics: Animals; Calcium; Dogs; Enzyme Activation; Female; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; Nifedipine; Phenylephrine; Phorbol 12,13-Dibutyrate; Potassium Chloride; Protein Kinase C; Saphenous Vein | 1988 |
[Ca2+]-dependent myosin phosphorylation in phorbol diester stimulated smooth muscle contraction.
Topics: Animals; Calcium; Carotid Arteries; In Vitro Techniques; Kinetics; Muscle Contraction; Muscle, Smooth, Vascular; Myosin Subfragments; Myosins; Peptide Fragments; Phorbol 12,13-Dibutyrate; Phosphorylation; Reference Values; Swine | 1988 |
Effect of phorbol ester on contractile response of aorta from endotoxic rats.
Topics: Animals; Aorta; Endotoxins; Escherichia coli; Isometric Contraction; Kinetics; Male; Muscle Contraction; Muscle, Smooth, Vascular; Phorbol 12,13-Dibutyrate; Phorbol Esters; Potassium Chloride; Rats; Rats, Inbred Strains | 1988 |
Phorbol ester-induced contraction in chemically skinned vascular smooth muscle.
Topics: Animals; Calcium; Carotid Arteries; Enzyme Activation; Kinetics; Muscle Contraction; Muscle, Smooth, Vascular; Myosins; Phorbol 12,13-Dibutyrate; Phorbol Esters; Phosphorylation; Potassium; Protein Kinase C; Skin Physiological Phenomena; Swine; Tetradecanoylphorbol Acetate | 1986 |
Phorbol ester contracts rabbit thoracic aorta by increasing intracellular calcium and by activating calcium influx.
Topics: Animals; Biological Transport; Calcium; Colforsin; Cytoplasm; Extracellular Space; Male; Muscle Contraction; Muscle, Smooth, Vascular; Nifedipine; Phorbol 12,13-Dibutyrate; Phorbol Esters; Prazosin; Protein Kinase C; Rabbits; Time Factors | 1986 |
Phorbol diesters alter the contractile responses of porcine coronary artery.
Topics: Animals; Calcium; Drug Synergism; Histamine; Muscle Contraction; Muscle, Smooth, Vascular; Norepinephrine; Phorbol 12,13-Dibutyrate; Phorbol Esters; Polymyxin B; Potassium; Protein Kinase C; Swine; Tetradecanoylphorbol Acetate | 1986 |
4 beta-PDBu contracts parenchymal strip and synergizes with raised cytosolic calcium.
Topics: Animals; Calcium; Cytosol; Dimethyl Sulfoxide; Guinea Pigs; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Phorbol 12,13-Dibutyrate; Phorbol Esters; Tetradecanoylphorbol Acetate | 1987 |
Phorbol 12,13-dibutyrate-induced contraction of isolated rabbit vascular smooth muscle.
Topics: Animals; Basilar Artery; Calcium Chloride; Carcinogens; In Vitro Techniques; Muscle Contraction; Muscle, Smooth, Vascular; Phorbol 12,13-Dibutyrate; Phorbol Esters; Rabbits; Renal Artery | 1987 |
Activation of protein kinase C and contraction in skinned vascular smooth muscle.
Topics: Animals; Calcium; Carotid Arteries; Enzyme Activation; In Vitro Techniques; Muscle Contraction; Muscle, Smooth, Vascular; Myosins; Phorbol 12,13-Dibutyrate; Phorbol Esters; Protein Kinase C; Swine | 1987 |