phorbol 12,13-dibutyrate has been researched along with Alzheimer Disease in 24 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (4.17) | 18.7374 |
| 1990's | 17 (70.83) | 18.2507 |
| 2000's | 5 (20.83) | 29.6817 |
| 2010's | 1 (4.17) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chen, M; Maleski, JJ; Nguyen, HT; Sawmiller, DR; Wu, Q | 1 |
| Hefco, V; Mamiya, T; Nabeshima, T; Olariu, A; Yamada, K | 1 |
| Boo, JH; Jung, MW; Kim, SU; Kim, YH; Lee, W; Mook-Jung, I; Park, SD | 1 |
| Chen, M; Fernandez, HL | 1 |
| Gandy, S; Greengard, P; Xu, H | 1 |
| Beyreuther, K; Fuller, SJ; Li, QX; Masters, CL; Smith, AI; Storey, E | 1 |
| Felsenstein, KM; Hunihan, LW; Ingalls, KM; Roberts, SB | 1 |
| Delvaux, A; Demaerschalck, I; Octave, JN | 1 |
| Battaini, F; Bergamaschi, S; Bianchetti, A; Binetti, G; Govoni, S; Racchi, M; Trabucchi, M | 1 |
| Hagiwara, M; Hidaka, H; Kameyama, M; Kimura, J; Matsushima, H; Narita, M; Shimohama, S; Taniguchi, T | 1 |
| da Cruz e Silva, EF; da Cruz e Silva, OA; Greengard, P; Zaia, CT | 1 |
| Blass, JP; Carroll, RT; Gandy, S; Gibson, GE; Kim, KS; Martins, RN; Sweeney, D; Turner, BA; Wisniewski, HM | 1 |
| Battaini, F; Bergamaschi, S; Bianchetti, A; Binetti, G; Govoni, S; Racchi, M; Trabucchi, M; Wetsel, WC | 1 |
| Checler, F; Lopez-Perez, E; Marambaud, P; Wilk, S | 1 |
| Bogdanovic, N; Bonkale, WL; Cowburn, RF; Fastbom, J; Kurumatani, T; Ohm, TG; Winblad, B | 1 |
| Bhagavan, S; Etcheberrigaray, R; Ibarreta, D; Kozikowski, AP; Ma, D | 1 |
| Duchén, M; Etcheberrigaray, R; Ibarreta, D; Kozikowski, AP; Ma, D; Qiao, L | 1 |
| Ha, MJ; Huh, K; Jung, MW; Kim, SU; Masliah, E; Mook-Jung, I; Savage, MJ; Yeon, SW | 1 |
| Bang, JH; Jang, CH; Joo, I; Jung, MW; Kim, C; Kim, SU; Mook-Jung, I | 1 |
| Coffin, JM; Haunton-Kreps, M; Moon, SL; Sasse, DK; Woodruff-Pak, DS | 1 |
| Bruel, A; Cherqui, G; Columelli, S; Delabar, J; Margelin, D; Pérignon, JL; Prieur, M; Roudier, M; Sinet, PM | 1 |
| Dewar, D; Graham, DI; Horsburgh, K; McCulloch, J | 1 |
| Buxbaum, JD; Cicchetti, P; Czernik, AJ; Ehrlich, ME; Fracasso, RP; Gandy, SE; Greengard, P; Ramabhadran, TV; Unterbeck, AJ | 1 |
| Cole, G; Dobkins, KR; Hansen, LA; Saitoh, T; Terry, RD | 1 |
24 other study(ies) available for phorbol 12,13-dibutyrate and Alzheimer Disease
| Article | Year |
|---|---|
Evidence supporting the role of calpain in the α-processing of amyloid-β precursor protein.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Biotinylation; Calpain; Cell Membrane; Genetic Vectors; Glutamic Acid; HEK293 Cells; Humans; Nicotine; Phorbol 12,13-Dibutyrate; Substrate Specificity | 2012 |
Memory impairment induced by chronic intracerebroventricular infusion of beta-amyloid (1-40) involves downregulation of protein kinase C.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Binding Sites; Brain; Cell Membrane; Cerebral Cortex; Chronic Disease; Disease Models, Animal; Down-Regulation; Hippocampus; Injections, Intraventricular; Male; Memory Disorders; Neostriatum; Peptide Fragments; Phorbol 12,13-Dibutyrate; Protein Kinase C; Protein Transport; Rats; Rats, Wistar; Subcellular Fractions | 2002 |
Amyloid beta peptide directly inhibits PKC activation.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Brain; Cell Line, Tumor; Dose-Response Relationship, Drug; Feedback, Physiological; Neurons; Peptide Fragments; Phorbol 12,13-Dibutyrate; Phosphorylation; Protein Kinase C; Protein Kinase C-alpha; Protein Kinase C-epsilon; Protein Structure, Tertiary; Rats | 2004 |
Mu-calpain is functionally required for alpha-processing of Alzheimer's beta-amyloid precursor protein.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Calpain; Cell Line; Gene Expression Regulation, Enzymologic; Humans; Peptide Fragments; Phorbol 12,13-Dibutyrate; Protein Processing, Post-Translational; RNA, Small Interfering | 2005 |
Regulated formation of Golgi secretory vesicles containing Alzheimer beta-amyloid precursor protein.
Topics: Aluminum Compounds; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Biological Transport, Active; Cell-Free System; Enzyme Activation; Fluorides; Golgi Apparatus; Guanosine 5'-O-(3-Thiotriphosphate); Humans; PC12 Cells; Phorbol 12,13-Dibutyrate; Protein Kinase C; Rats | 1995 |
Intracellular production of beta A4 amyloid of Alzheimer's disease: modulation by phosphoramidon and lack of coupling to the secretion of the amyloid precursor protein.
Topics: Alzheimer Disease; Ammonium Chloride; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Aspartic Acid Endopeptidases; Chloroquine; Endopeptidases; Enzyme Activation; Glycopeptides; Humans; Immunosorbent Techniques; Kinetics; Neuroblastoma; Phorbol 12,13-Dibutyrate; Protease Inhibitors; Protein Kinase C; Tumor Cells, Cultured | 1995 |
Reversal of the Swedish familial Alzheimer's disease mutant phenotype in cultured cells treated with phorbol 12,13-dibutyrate.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Cells, Cultured; Cholinergic Antagonists; Humans; Immunoblotting; Mutation; Phenotype; Phorbol 12,13-Dibutyrate; Protein Kinase C; Sweden | 1994 |
Activation of protein kinase C increases the extracellular release of the transmembrane amyloid protein precursor of Alzheimer's disease.
Topics: Alkaloids; Alzheimer Disease; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Animals; Cell Membrane; CHO Cells; Cricetinae; Cricetulus; Endopeptidases; Enzyme Activation; Phorbol 12,13-Dibutyrate; Protein Kinase C; Staurosporine; Transfection | 1993 |
Cytosol protein kinase C downregulation in fibroblasts from Alzheimer's disease patients.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Cytosol; Female; Fibroblasts; Humans; Male; Phorbol 12,13-Dibutyrate; Protein Kinase C; Skin | 1993 |
Assessment of protein kinase C isozymes by two-site enzyme immunoassay in human brains and changes in Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Analysis of Variance; Brain; Female; Humans; Immunoenzyme Techniques; Isoenzymes; Kinetics; Male; Phorbol 12,13-Dibutyrate; Protein Kinase C; Radioligand Assay | 1993 |
Inhibition of protein phosphatase 1 stimulates secretion of Alzheimer amyloid precursor protein.
Topics: Aged; Alzheimer Disease; Amyloid; Amyloid Precursor Protein Secretases; Aspartic Acid Endopeptidases; Cantharidin; Cell Line; Endopeptidases; Enzyme Inhibitors; Ethers, Cyclic; Humans; Immunoblotting; Marine Toxins; Okadaic Acid; Oxazoles; Phorbol 12,13-Dibutyrate; Phosphoprotein Phosphatases; Prion Proteins; Prions; Protein Phosphatase 1; Protein Precursors | 1995 |
High levels of amyloid-beta protein from S182 (Glu246) familial Alzheimer's cells.
Topics: Age of Onset; Alzheimer Disease; Amyloid beta-Protein Precursor; Blood Physiological Phenomena; Case-Control Studies; Cells, Cultured; Culture Media, Conditioned; Fibroblasts; Humans; Membrane Proteins; Nerve Tissue Proteins; Phorbol 12,13-Dibutyrate; Point Mutation; Presenilin-1; Skin | 1995 |
Defective phorbol ester-stimulated secretion of beta-amyloid precursor protein from Alzheimer's disease fibroblasts.
Topics: Aged; Alzheimer Disease; Amyloid beta-Protein Precursor; Blotting, Western; Female; Fibroblasts; Humans; Isoenzymes; Male; Middle Aged; Phorbol 12,13-Dibutyrate; Protein Kinase C; Skin; Stimulation, Chemical | 1995 |
Constitutive and protein kinase C-regulated secretory cleavage of Alzheimer's beta-amyloid precursor protein: different control of early and late events by the proteasome.
Topics: Acetylcysteine; Alzheimer Disease; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Animals; Aspartic Acid Endopeptidases; Cell Line; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Endopeptidases; Enzyme Inhibitors; Humans; Multienzyme Complexes; Oligopeptides; PC12 Cells; Phorbol 12,13-Dibutyrate; Proteasome Endopeptidase Complex; Protein Kinase C; Rats; Time Factors | 1997 |
Loss of inositol 1,4,5-trisphosphate receptor sites and decreased PKC levels correlate with staging of Alzheimer's disease neurofibrillary pathology.
Topics: Adult; Aged; Aged, 80 and over; Aging; Alzheimer Disease; Amyloid; Autoradiography; Calcium Channels; Female; Humans; Inositol 1,4,5-Trisphosphate Receptors; Male; Middle Aged; Neurofibrillary Tangles; Phorbol 12,13-Dibutyrate; Postmortem Changes; Protein Kinase C; Receptors, Cytoplasmic and Nuclear | 1998 |
Restoration of TEA-induced calcium responses in fibroblasts from Alzheimer's disease patients by a PKC activator.
Topics: Alzheimer Disease; Calcium; Carcinogens; Cells, Cultured; Dimethyl Sulfoxide; Enzyme Activation; Excipients; Fibroblasts; Humans; Immunoblotting; Lactams; Patch-Clamp Techniques; Phorbol 12,13-Dibutyrate; Phorbols; Potassium Channels; Protein Kinase C; Tetraethylammonium | 1998 |
Benzolactam (BL) enhances sAPP secretion in fibroblasts and in PC12 cells.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Cells, Cultured; Enzyme Activation; Enzyme Inhibitors; Fibroblasts; Humans; Lactams; PC12 Cells; Phorbol 12,13-Dibutyrate; Protein Kinase C; Rats; Reference Values; Solubility; Staurosporine | 1999 |
Blockade of PKC epsilon activation attenuates phorbol ester-induced increase of alpha-secretase-derived secreted form of amyloid precursor protein.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Animals; Aspartic Acid Endopeptidases; Base Sequence; Brain; Case-Control Studies; Cell Line; DNA Primers; Endopeptidases; Enzyme Activation; Humans; Isoenzymes; Phorbol 12,13-Dibutyrate; Protein Kinase C; Protein Kinase C-epsilon; Protein Processing, Post-Translational; Rats; Transfection | 2001 |
Amyloid precursor protein processing is separately regulated by protein kinase C and tyrosine kinase in human astrocytes.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Astrocytes; Brain; Cells, Cultured; Drug Interactions; Enzyme Inhibitors; Fetus; Flavonoids; Genistein; Glial Fibrillary Acidic Protein; Humans; Indoles; Maleimides; MAP Kinase Signaling System; Phorbol 12,13-Dibutyrate; Platelet-Derived Growth Factor; Protein Kinase C; Protein-Tyrosine Kinases | 2002 |
Effect of BMY 21502 on classical conditioning of the eyeblink response in young and older rabbits.
Topics: Aging; Alzheimer Disease; Animals; Blinking; Conditioning, Classical; Female; Male; Phorbol 12,13-Dibutyrate; Protein Kinase C; Pyrimidines; Pyrrolidinones; Rabbits | 1991 |
Reduced protein kinase C activity in sporadic Alzheimer's disease fibroblasts.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Alzheimer Disease; Child; Child, Preschool; Fibroblasts; Humans; Leukocytes; Middle Aged; Phorbol 12,13-Dibutyrate; Phosphorylation; Protein Kinase C | 1991 |
Autoradiographic imaging of [3H]phorbol 12,13-dibutyrate binding to protein kinase C in Alzheimer's disease.
Topics: Alzheimer Disease; Autoradiography; Cytosol; Humans; Phorbol 12,13-Dibutyrate; Protein Kinase C; Tissue Distribution; Tritium | 1991 |
Processing of Alzheimer beta/A4 amyloid precursor protein: modulation by agents that regulate protein phosphorylation.
Topics: Adrenal Gland Neoplasms; Alzheimer Disease; Amyloid; Amyloid beta-Protein Precursor; Animals; Cell Line; Ethers, Cyclic; Humans; Kinetics; Methionine; Molecular Weight; Okadaic Acid; Pheochromocytoma; Phorbol 12,13-Dibutyrate; Phosphorylation; Protein Biosynthesis; Protein Kinase C; Protein Precursors; Protein Processing, Post-Translational; Tetradecanoylphorbol Acetate; Transcription, Genetic | 1990 |
Decreased levels of protein kinase C in Alzheimer brain.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Female; Frontal Lobe; Humans; Male; Middle Aged; Phorbol 12,13-Dibutyrate; Phorbol Esters; Phosphoproteins; Phosphorylation; Protein Kinase C; Subcellular Fractions | 1988 |