Page last updated: 2024-10-17

phloroglucinol and Pregnancy

phloroglucinol has been researched along with Pregnancy in 29 studies

Phloroglucinol: A trinitrobenzene derivative with antispasmodic properties that is used primarily as a laboratory reagent.
phloroglucinol : A benzenetriol with hydroxy groups at position 1, 3 and 5.

Pregnancy: The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.

Research Excerpts

ExcerptRelevanceReference
"To observe the effect of phloroglucinol on plasma angiotensin II and D-dimer index when it was applied to patients with severe pregnancy-induced hypertension."9.22Clinical study on the influence of phloroglucinol on plasma angiotensin II and D-Dimer index in patients with severe pregnancy-induced hypertension. ( Ai, L; Lan, X; Wang, L; Xu, Y; Zhang, B, 2016)
"This first epidemiologic study about phloroglucinol in pregnancy does not support evidence of a teratogenic risk for phloroglucinol in humans."7.77[First epidemiologic data about phloroglucinol exposure during first trimester of pregnancy]. ( Albouy-Cossard, C; Damase-Michel, C; Guitard, C; Hurault-Delarue, C; Kessler, S; Lacroix, I; Montastruc, JL; Vidal, S, 2011)
" Participants greater than 18 years with singleton uncomplicated pregnancy who consented following randomisation, were administered either 80mg/8ml intravenous phloroglucinol or 8ml of sterile water when in active labour."5.27Effects of phloroglucinol on the active phase of labour (EPAL trial): a single blinded randomised controlled trial in a tertiary hospital in sub-Sahara Africa. ( Abanda, MH; Angong, FTE; Belley, EP; Doualla, MS; Kenfack, GU; Mangala, GN; Muhammad, S; Nana, TN; Tamambang, RF; Tchente, CN; Tolefac, PN, 2018)
"A meta-analysis of 5 trials found that Phloroglucinol favorably impacts on the total duration of the labor in primiparae and multiparae women with a singleton pregnancy."5.22Efficacy of phloroglucinol in shortening the first stage of labor: systematic review and meta-analysis of randomized controlled trials. ( De Franciscis, P; Morlando, M; Rapisarda, A; Riemma, G; Savoia, F; Schiattarella, A; Sisti, G, 2022)
"To observe the effect of phloroglucinol on plasma angiotensin II and D-dimer index when it was applied to patients with severe pregnancy-induced hypertension."5.22Clinical study on the influence of phloroglucinol on plasma angiotensin II and D-Dimer index in patients with severe pregnancy-induced hypertension. ( Ai, L; Lan, X; Wang, L; Xu, Y; Zhang, B, 2016)
"The recent clinical studies on hypericum extract support the present indications for its use in mild to moderate depression and depressive episodes."4.84[New developments in hypericum extracts: data on efficacy and interactions]. ( Kraft, K, 2007)
" The purpose of this systematic study was to evaluate the efficacy and safety of phloroglucinol (PHL) combined with progesterone in the treatment of TM before 20 weeks of pregnancy."4.12Meta analysis of the effect of phloroglucinol combined with progesterone in the treatment of threatened miscarriage before 20 weeks of gestation: A protocol for a systematic review. ( Lan, T; Liu, S; Peng, Y; Wang, Y; Ye, T; Zhang, J, 2022)
"This first epidemiologic study about phloroglucinol in pregnancy does not support evidence of a teratogenic risk for phloroglucinol in humans."3.77[First epidemiologic data about phloroglucinol exposure during first trimester of pregnancy]. ( Albouy-Cossard, C; Damase-Michel, C; Guitard, C; Hurault-Delarue, C; Kessler, S; Lacroix, I; Montastruc, JL; Vidal, S, 2011)
"0 software were used to compare and analyze the 2 drugs in terms of the total effective rate (TER), rate of adverse events, time required to relieve uterine contractions, onset time, time of complete relief of uterine contraction symptoms, medication duration and length of hospital stay."2.61Comparison of the efficacy and safety of phloroglucinol and magnesium sulfate in the treatment of threatened abortion: A meta-analysis of randomized controlled trials. ( Gao, F; Guan, J; Guo, H; Shi, L; Shi, S; Xin, Z; Yang, X; Yuan, S, 2019)
" A study was performed after the drug was administered to examine its effects on the duration of labor (including the first, second, and third stages of labor), the mode of delivery (including natural vaginal delivery and cesarean section), the incidence of adverse pregnancy outcomes (fetal distress and neonatal asphyxia), successful labor induction, and complication rates."1.72Efficacy and Safety Analysis of Phloroglucinol in Combination with Oxytocin for the Induction of Labor in Women with Term Premature Rupture of Membranes (PROM). ( Chen, L; Li, X; Wang, X; Yu, J, 2022)

Research

Studies (29)

TimeframeStudies, this research(%)All Research%
pre-19905 (17.24)18.7374
1990's2 (6.90)18.2507
2000's6 (20.69)29.6817
2010's10 (34.48)24.3611
2020's6 (20.69)2.80

Authors

AuthorsStudies
Yu, J1
Chen, L1
Wang, X1
Li, X1
Peng, Y3
Zhang, J3
Lan, T3
Liu, S3
Ye, T3
Wang, Y3
Clara, B1
Paul, V1
Denis, P1
Stéphanie, M1
Hélène, VR1
Rémy, B1
Birene, B1
Ishaque, U1
Chrusciel, J1
Bonneau, S1
Gabriel, R1
Graesslin, O1
Wu, F1
Chen, Y1
Zheng, C1
Schiattarella, A1
Riemma, G1
Sisti, G1
Savoia, F1
Rapisarda, A1
De Franciscis, P1
Morlando, M1
Tchente, CN1
Nana, TN1
Tolefac, PN1
Abanda, MH1
Angong, FTE1
Tamambang, RF1
Kenfack, GU1
Mangala, GN1
Muhammad, S1
Doualla, MS1
Belley, EP1
Yuan, S1
Gao, F1
Xin, Z1
Guo, H1
Shi, S1
Shi, L1
Yang, X1
Guan, J1
Xu, A1
Li, Y1
Zhu, L1
Tian, T1
Hao, J1
Zhao, J1
Zhang, Q1
Veena, VK1
Popavath, RN1
Kennedy, K1
Sakthivel, N1
Yang, EJ1
Ahn, S1
Ryu, J1
Choi, MS1
Choi, S1
Chong, YH1
Hyun, JW1
Chang, MJ1
Kim, HS1
Ai, L1
Lan, X1
Wang, L1
Xu, Y1
Zhang, B1
Zhuang, Y1
Zhu, X1
Huang, LL1
Lacroix, I2
Hurault-Delarue, C2
Kessler, S1
Guitard, C1
Vidal, S2
Albouy-Cossard, C1
Montastruc, JL2
Damase-Michel, C2
Gibon, J1
Deloulme, JC1
Chevallier, T1
Ladevèze, E1
Abrous, DN1
Bouron, A1
MORIN, P1
HAMELIN, R1
GREPINET, J1
Hao, Y1
Zhai, GR1
Duan, AH1
Stöter, M1
Bamberger, AM1
Aslan, B1
Kurth, M1
Speidel, D1
Löning, T1
Frank, HG1
Kaufmann, P1
Löhler, J1
Henne-Bruns, D1
Deppert, W1
Knippschild, U1
Tabassum, S2
Afridi, B1
Aman, Z1
Klier, CM1
Schmid-Siegel, B1
Schäfer, MR1
Lenz, G1
Saria, A1
Lee, A1
Zernig, G1
Kraft, K1
Ruscillo, MM1
Hunt, EJ1
Lester, CE1
Lester, EA1
Tackett, RL1
Hourcabie, J1
Ambonville, C1
Albalat, F1
Becat, A1
Weber, B1
Fontan, JE1
Scheller, E1
Debu, E1
Majorel, P1
Dufour, B1
Speroff, L1
Ramwell, PW1
Eakins, K1
Foti, A1
Penazzo, S1
Volpe, L1

Reviews

6 reviews available for phloroglucinol and Pregnancy

ArticleYear
Efficacy of phloroglucinol for the treatment of pain of gynaecologic or obstetrical origin: a systematic review of literature of randomised controlled trials.
    European journal of clinical pharmacology, 2020, Volume: 76, Issue:1

    Topics: Dysmenorrhea; Female; Humans; Labor Pain; Parasympatholytics; Phloroglucinol; Pregnancy; Randomized

2020
Efficacy of phloroglucinol for acceleration of labour: a systematic review and meta‑analysis.
    Archives of gynecology and obstetrics, 2021, Volume: 304, Issue:2

    Topics: Acceleration; Female; Humans; Labor, Obstetric; Phloroglucinol; Pregnancy

2021
Efficacy of phloroglucinol in shortening the first stage of labor: systematic review and meta-analysis of randomized controlled trials.
    The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, 2022, Volume: 35, Issue:25

    Topics: Female; Humans; Labor, Obstetric; Parasympatholytics; Phloroglucinol; Pregnancy; Randomized Controll

2022
Comparison of the efficacy and safety of phloroglucinol and magnesium sulfate in the treatment of threatened abortion: A meta-analysis of randomized controlled trials.
    Medicine, 2019, Volume: 98, Issue:24

    Topics: Abortion, Threatened; Female; Humans; Magnesium Sulfate; Phloroglucinol; Pregnancy; Randomized Contr

2019
[New developments in hypericum extracts: data on efficacy and interactions].
    Wiener medizinische Wochenschrift (1946), 2007, Volume: 157, Issue:13-14

    Topics: Adolescent; Adult; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Bridg

2007
Prostaglandins in reproductive physiology.
    American journal of obstetrics and gynecology, 1970, Aug-01, Volume: 107, Issue:7

    Topics: Animals; Chemical Phenomena; Chemistry; Fallopian Tubes; Female; Humans; Male; Ovary; Phloroglucinol

1970

Trials

6 trials available for phloroglucinol and Pregnancy

ArticleYear
Effects of phloroglucinol on the active phase of labour (EPAL trial): a single blinded randomised controlled trial in a tertiary hospital in sub-Sahara Africa.
    The Pan African medical journal, 2018, Volume: 30

    Topics: Adult; Cameroon; Female; Humans; Infant, Newborn; Labor Stage, First; Labor, Obstetric; Phloroglucin

2018
Clinical study on the influence of phloroglucinol on plasma angiotensin II and D-Dimer index in patients with severe pregnancy-induced hypertension.
    Pakistan journal of pharmaceutical sciences, 2016, Volume: 29, Issue:4 Suppl

    Topics: Adult; Angiotensin II; Antihypertensive Agents; Female; Fibrin Fibrinogen Degradation Products; Huma

2016
The effect of phloroglucinol on pain in first-trimester surgical abortion: a double-blind randomized controlled study.
    Contraception, 2010, Volume: 81, Issue:2

    Topics: Abortion, Induced; Adolescent; Adult; Double-Blind Method; Female; Humans; Pain Measurement; Pain, P

2010
[Effects of Spasfon on course of labor].
    Zhonghua fu chan ke za zhi, 2004, Volume: 39, Issue:9

    Topics: Administration, Intravaginal; Adult; Atropine; Cervical Ripening; Cervix Uteri; Delivery, Obstetric;

2004
Phloroglucinol for acceleration of labour: double blind, randomized controlled trial.
    JPMA. The Journal of the Pakistan Medical Association, 2005, Volume: 55, Issue:7

    Topics: Female; Humans; Labor Onset; Labor Stage, First; Labor Stage, Second; Labor Stage, Third; Labor, Obs

2005
[Voluntary abortion induced by mifepristone-sulprostone combination. Effect of phloroglucinol on the time required for expulsion in multipara women].
    Presse medicale (Paris, France : 1983), 1992, Feb-08, Volume: 21, Issue:5

    Topics: Abortifacient Agents, Nonsteroidal; Abortion, Induced; Adult; Dinoprostone; Drug Therapy, Combinatio

1992

Other Studies

17 other studies available for phloroglucinol and Pregnancy

ArticleYear
Efficacy and Safety Analysis of Phloroglucinol in Combination with Oxytocin for the Induction of Labor in Women with Term Premature Rupture of Membranes (PROM).
    Computational and mathematical methods in medicine, 2022, Volume: 2022

    Topics: Cervical Ripening; Cesarean Section; Female; Humans; Infant, Newborn; Labor, Induced; Oxytocics; Oxy

2022
Meta analysis of the effect of phloroglucinol combined with progesterone in the treatment of threatened miscarriage before 20 weeks of gestation: A protocol for a systematic review.
    Medicine, 2022, Nov-25, Volume: 101, Issue:47

    Topics: Abortion, Threatened; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Meta-Analysis

2022
Meta analysis of the effect of phloroglucinol combined with progesterone in the treatment of threatened miscarriage before 20 weeks of gestation: A protocol for a systematic review.
    Medicine, 2022, Nov-25, Volume: 101, Issue:47

    Topics: Abortion, Threatened; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Meta-Analysis

2022
Meta analysis of the effect of phloroglucinol combined with progesterone in the treatment of threatened miscarriage before 20 weeks of gestation: A protocol for a systematic review.
    Medicine, 2022, Nov-25, Volume: 101, Issue:47

    Topics: Abortion, Threatened; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Meta-Analysis

2022
Meta analysis of the effect of phloroglucinol combined with progesterone in the treatment of threatened miscarriage before 20 weeks of gestation: A protocol for a systematic review.
    Medicine, 2022, Nov-25, Volume: 101, Issue:47

    Topics: Abortion, Threatened; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Meta-Analysis

2022
Influence of the external cephalic version attempt on the Cesarean section rate: experience of a type 3 maternity hospital in France.
    Archives of gynecology and obstetrics, 2021, Volume: 303, Issue:2

    Topics: Adult; Albuterol; Breech Presentation; Cardiotocography; Cesarean Section; Delivery, Obstetric; Fema

2021
Inhibition of endometrial fundocervical wave by phloroglucinol and the outcome of in vitro fertilization.
    Reproductive biology, 2013, Volume: 13, Issue:1

    Topics: Adult; Embryo Transfer; Endometrium; Feasibility Studies; Female; Fertilization in Vitro; Humans; Pa

2013
In vitro antiproliferative, pro-apoptotic, antimetastatic and anti-inflammatory potential of 2,4-diacetylphloroglucinol (DAPG) by Pseudomonas aeruginosa strain FP10.
    Apoptosis : an international journal on programmed cell death, 2015, Volume: 20, Issue:10

    Topics: Animals; Antineoplastic Agents; Apoptosis; Apoptosis Regulatory Proteins; Cell Line; Cell Line, Tumo

2015
Phloroglucinol Attenuates the Cognitive Deficits of the 5XFAD Mouse Model of Alzheimer's Disease.
    PloS one, 2015, Volume: 10, Issue:8

    Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Cell Line; Cognition; Dendritic Spines; Disease M

2015
[First epidemiologic data about phloroglucinol exposure during first trimester of pregnancy].
    Gynecologie, obstetrique & fertilite, 2011, Volume: 39, Issue:12

    Topics: Abnormalities, Drug-Induced; Adult; Cohort Studies; Female; Humans; Infant, Newborn; Phloroglucinol;

2011
[Drugs in pregnancy: study in the EFEMERIS database (2004 to 2008)].
    Gynecologie, obstetrique & fertilite, 2011, Volume: 39, Issue:10

    Topics: Acetaminophen; Databases, Factual; Drug Prescriptions; Female; Folic Acid; Humans; Immune Sera; Immu

2011
The antidepressant hyperforin increases the phosphorylation of CREB and the expression of TrkB in a tissue-specific manner.
    The international journal of neuropsychopharmacology, 2013, Volume: 16, Issue:1

    Topics: Age Factors; Animals; Antidepressive Agents; Cells, Cultured; Cerebral Cortex; Cyclic AMP Response E

2013
[THE PHLOROGLUCINOL-TRIMETHOXYBENZENE COMBINATION IN OBSTETRICS].
    La Presse medicale, 1964, Dec-05, Volume: 72

    Topics: Adjuvants, Anesthesia; Anesthesia; Anesthesia, Obstetrical; Dystocia; Female; Humans; Labor, Induced

1964
Inhibition of casein kinase I delta alters mitotic spindle formation and induces apoptosis in trophoblast cells.
    Oncogene, 2005, Dec-01, Volume: 24, Issue:54

    Topics: Apoptosis; Blotting, Western; Casein Kinase Idelta; Cell Line; Cell Line, Transformed; Cell Survival

2005
St. John's wort (Hypericum perforatum) and breastfeeding: plasma and breast milk concentrations of hyperforin for 5 mothers and 2 infants.
    The Journal of clinical psychiatry, 2006, Volume: 67, Issue:2

    Topics: Adult; Breast Feeding; Bridged Bicyclo Compounds; Depressive Disorder; Female; Humans; Hypericum; In

2006
[Fever and pregnancy].
    Soins. Gynecologie, obstetrique, puericulture, pediatrie, 1993, Issue:143

    Topics: Amoxicillin; Diagnosis, Differential; Drug Combinations; Female; Fever; Humans; Nephritis, Interstit

1993
Effect of St. John's wort on free radical production.
    Life sciences, 2001, Jun-01, Volume: 69, Issue:2

    Topics: 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt; Anthracenes; Antioxidants; Bridged Bicyclo C

2001
[Value of the rapid perfusion of Spasfon in high doses in dynamic dystocia and anomalies of dilatation].
    Journal de gynecologie, obstetrique et biologie de la reproduction, 1976, Volume: 5, Issue:6

    Topics: Drug Combinations; Drug Evaluation; Dystocia; Female; Fetus; Humans; Infusions, Parenteral; Parasymp

1976
Prostaglandin antagonism by polymeric phosphates of phloretin and related compounds.
    Annals of the New York Academy of Sciences, 1971, Apr-30, Volume: 180

    Topics: Animals; Aqueous Humor; Blood Pressure; Carbachol; Depression, Chemical; Diarrhea; Estradiol; Eye Pr

1971
[Use of a new spasmolytic agent (Spasmex) in obstetrics].
    Minerva ginecologica, 1971, May-31, Volume: 23, Issue:10

    Topics: Abortion, Threatened; Adolescent; Adult; Benzene Derivatives; Electrocardiography; Ethers; Female; H

1971