phloroglucinol has been researched along with Innate Inflammatory Response in 23 studies
Phloroglucinol: A trinitrobenzene derivative with antispasmodic properties that is used primarily as a laboratory reagent.
phloroglucinol : A benzenetriol with hydroxy groups at position 1, 3 and 5.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Histological evaluation showed that bladder inflammation in CYP-treated rats was suppressed by phloroglucinol." | 7.81 | Phloroglucinol protects the urinary bladder via inhibition of oxidative stress and inflammation in a rat model of cyclophosphamide-induced interstitial cystitis. ( He, YQ; Ma, LL; Shi, CH; Tian, XJ; Wang, FM; Zhang, WT, 2015) |
| " perforatum extract on paracetamol (acetaminophen)-induced hepatotoxicity, lethality, inflammation, and oxidative stress in male swiss mice were investigated." | 7.81 | Hypericum perforatum Reduces Paracetamol-Induced Hepatotoxicity and Lethality in Mice by Modulating Inflammation and Oxidative Stress. ( Arakawa, NS; Cardoso, RD; Casagrande, R; Fattori, V; Hohmann, MS; Lopes, NP; Tomaz, JC; Verri, WA, 2015) |
| "The cuprizone-induced model was used in this study to mimic the pathological progress of MS." | 5.56 | Phloroglucinol derivative compound 21 attenuates cuprizone-induced multiple sclerosis mice through promoting remyelination and inhibiting neuroinflammation. ( Bao, XQ; Liu, H; Zhang, D; Zhang, Z; Zhao, Z, 2020) |
| "fragrans (L." | 5.43 | Investigation of antibacterial activity of aspidin BB against Propionibacterium acnes. ( Fu, YJ; Gao, C; Guo, N; Li, N; Luo, M; Peng, X; Wang, P; Wang, W, 2016) |
| "Histological evaluation showed that bladder inflammation in CYP-treated rats was suppressed by phloroglucinol." | 3.81 | Phloroglucinol protects the urinary bladder via inhibition of oxidative stress and inflammation in a rat model of cyclophosphamide-induced interstitial cystitis. ( He, YQ; Ma, LL; Shi, CH; Tian, XJ; Wang, FM; Zhang, WT, 2015) |
| " perforatum extract on paracetamol (acetaminophen)-induced hepatotoxicity, lethality, inflammation, and oxidative stress in male swiss mice were investigated." | 3.81 | Hypericum perforatum Reduces Paracetamol-Induced Hepatotoxicity and Lethality in Mice by Modulating Inflammation and Oxidative Stress. ( Arakawa, NS; Cardoso, RD; Casagrande, R; Fattori, V; Hohmann, MS; Lopes, NP; Tomaz, JC; Verri, WA, 2015) |
| "Arzanol is a novel phloroglucinol α -pyrone, isolated from a Mediterranean plant Helichrysum italicum (Roth) Don ssp." | 2.49 | Arzanol, a potent mPGES-1 inhibitor: novel anti-inflammatory agent. ( Bulani, VD; Juvekar, AR; Kothavade, PS; Nagmoti, DM, 2013) |
| "The cuprizone-induced model was used in this study to mimic the pathological progress of MS." | 1.56 | Phloroglucinol derivative compound 21 attenuates cuprizone-induced multiple sclerosis mice through promoting remyelination and inhibiting neuroinflammation. ( Bao, XQ; Liu, H; Zhang, D; Zhang, Z; Zhao, Z, 2020) |
| "Neuroinflammation has been implicated as an important factor in the neurodegenerative diseases, and multiple candidates with anti-inflammatory effects have been shown to be beneficial for the treatment of neurodegenerative diseases." | 1.51 | A Novel Synthetic Derivative of Phloroglucinol Inhibits Neuroinflammatory Responses Through Attenuating Kalirin Signaling Pathway in Murine BV2 Microglial Cells. ( Bao, X; Wang, L; Wang, X; Wang, Y; Yang, H; Zang, C; Zhang, D, 2019) |
| "fragrans (L." | 1.43 | Investigation of antibacterial activity of aspidin BB against Propionibacterium acnes. ( Fu, YJ; Gao, C; Guo, N; Li, N; Luo, M; Peng, X; Wang, P; Wang, W, 2016) |
| " At present, there is no information on the bioavailability of seaweed polyphenols and limited evidence on their bioactivity in vivo." | 1.43 | Gastrointestinal modifications and bioavailability of brown seaweed phlorotannins and effects on inflammatory markers. ( Anegboonlap, P; Corona, G; Gill, C; Hotchkiss, S; Ji, Y; Rowland, I; Spencer, JP; Yaqoob, P, 2016) |
| "Phloroglucinol plays an important role in oxidative stress, inflammatory responses, and matrix metalloproteinase (MMP) regulation." | 1.38 | Barrier protective activities of phloroglucinol on lipopolysaccharide (LPS)-induced barrier disruption in human endothelial cells. ( Bae, JS, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (4.35) | 29.6817 |
| 2010's | 19 (82.61) | 24.3611 |
| 2020's | 3 (13.04) | 2.80 |
| Authors | Studies |
|---|---|
| Zhao, Z | 1 |
| Bao, XQ | 1 |
| Zhang, Z | 1 |
| Liu, H | 1 |
| Zhang, D | 2 |
| Choi, J | 2 |
| Oh, S | 3 |
| Son, M | 3 |
| Byun, K | 3 |
| Lee, HS | 1 |
| Chung, DM | 1 |
| Jang, JT | 2 |
| Jeon, YJ | 1 |
| Choi, CH | 2 |
| Park, KY | 2 |
| Son, KH | 2 |
| Novelli, M | 1 |
| Masiello, P | 1 |
| Beffy, P | 1 |
| Menegazzi, M | 1 |
| Drygalski, K | 1 |
| Fereniec, E | 1 |
| Zalewska, A | 1 |
| Krętowski, A | 1 |
| Żendzian-Piotrowska, M | 1 |
| Maciejczyk, M | 1 |
| Zang, C | 1 |
| Yang, H | 1 |
| Wang, L | 1 |
| Wang, Y | 1 |
| Bao, X | 1 |
| Wang, X | 1 |
| Peron, G | 1 |
| Hošek, J | 1 |
| Rajbhandary, S | 1 |
| Pant, DR | 1 |
| Dall'Acqua, S | 1 |
| Kang, YM | 1 |
| Eom, SH | 1 |
| Kim, YM | 1 |
| Kothavade, PS | 1 |
| Nagmoti, DM | 1 |
| Bulani, VD | 1 |
| Juvekar, AR | 1 |
| Kurihara, T | 1 |
| Sakurai, E | 1 |
| Toyomoto, M | 1 |
| Kii, I | 1 |
| Kawamoto, D | 1 |
| Asada, T | 1 |
| Tanabe, T | 1 |
| Yoshimura, M | 1 |
| Hagiwara, M | 1 |
| Miyata, A | 1 |
| Meinke, MC | 2 |
| Richter, H | 1 |
| Kleemann, A | 2 |
| Lademann, J | 2 |
| Tscherch, K | 1 |
| Rohn, S | 1 |
| Schempp, CM | 2 |
| He, YQ | 1 |
| Zhang, WT | 1 |
| Shi, CH | 1 |
| Wang, FM | 1 |
| Tian, XJ | 1 |
| Ma, LL | 1 |
| Hohmann, MS | 1 |
| Cardoso, RD | 1 |
| Fattori, V | 1 |
| Arakawa, NS | 1 |
| Tomaz, JC | 1 |
| Lopes, NP | 1 |
| Casagrande, R | 1 |
| Verri, WA | 1 |
| Veena, VK | 1 |
| Popavath, RN | 1 |
| Kennedy, K | 1 |
| Sakthivel, N | 1 |
| Gao, C | 1 |
| Guo, N | 1 |
| Li, N | 1 |
| Peng, X | 1 |
| Wang, P | 1 |
| Wang, W | 1 |
| Luo, M | 1 |
| Fu, YJ | 1 |
| Corona, G | 1 |
| Ji, Y | 1 |
| Anegboonlap, P | 1 |
| Hotchkiss, S | 1 |
| Gill, C | 1 |
| Yaqoob, P | 1 |
| Spencer, JP | 1 |
| Rowland, I | 1 |
| Chong, YJ | 1 |
| Musa, NF | 1 |
| Ng, CH | 1 |
| Shaari, K | 1 |
| Israf, DA | 1 |
| Tham, CL | 1 |
| Li, TT | 1 |
| Zhang, YS | 1 |
| He, L | 1 |
| Li, NS | 1 |
| Peng, J | 1 |
| Li, YJ | 1 |
| Bae, JS | 2 |
| Schanzer, S | 1 |
| Haag, SF | 1 |
| Casetti, F | 1 |
| Müller, ML | 1 |
| Wölfle, U | 1 |
| Kim, TH | 1 |
| Ku, SK | 1 |
| Lee, T | 1 |
| Dell'Aica, I | 1 |
| Niero, R | 1 |
| Piazza, F | 1 |
| Cabrelle, A | 1 |
| Sartor, L | 1 |
| Colalto, C | 1 |
| Brunetta, E | 1 |
| Lorusso, G | 1 |
| Benelli, R | 1 |
| Albini, A | 1 |
| Calabrese, F | 1 |
| Agostini, C | 1 |
| Garbisa, S | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Monitoring Response to Therapy in Atopic Dermatitis Patients Treated With Dupilumab Using Noninvasive Reflectance Confocal Microscopy and Optical Coherence Tomography[NCT05265234] | Phase 4 | 15 participants (Anticipated) | Interventional | 2022-03-01 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for phloroglucinol and Innate Inflammatory Response
| Article | Year |
|---|---|
Protective Role of St. John's Wort and Its Components Hyperforin and Hypericin against Diabetes through Inhibition of Inflammatory Signaling: Evidence from In Vitro and In Vivo Studies.
Topics: Animals; Diabetes Mellitus, Type 2; Humans; Hypericum; Inflammation; Phloroglucinol; Phytotherapy; P | 2020 |
Arzanol, a potent mPGES-1 inhibitor: novel anti-inflammatory agent.
Topics: Animals; Anti-HIV Agents; Anti-Inflammatory Agents; Antioxidants; Humans; Inflammation; Intramolecul | 2013 |
1 trial available for phloroglucinol and Innate Inflammatory Response
| Article | Year |
|---|---|
In vivo photoprotective and anti-inflammatory effect of hyperforin is associated with high antioxidant activity in vitro and ex vivo.
Topics: Administration, Topical; Adult; Animals; Anti-Inflammatory Agents; Antioxidants; Double-Blind Method | 2012 |
20 other studies available for phloroglucinol and Innate Inflammatory Response
| Article | Year |
|---|---|
Phloroglucinol derivative compound 21 attenuates cuprizone-induced multiple sclerosis mice through promoting remyelination and inhibiting neuroinflammation.
Topics: Animals; Astrocytes; Brain; Cuprizone; Cytokines; Disease Models, Animal; Drug Discovery; Inflammati | 2020 |
Pyrogallol-Phloroglucinol-6,6-Bieckol Alleviates Obesity and Systemic Inflammation in a Mouse Model by Reducing Expression of RAGE and RAGE Ligands.
Topics: Animals; Anti-Obesity Agents; Cytokines; Diet; Dioxins; Disease Models, Animal; Hypertrophy; Inflamm | 2019 |
Topics: Adipocytes, Brown; Adiponectin; Adipose Tissue; Animals; Anti-Inflammatory Agents; Chemokine CCL2; D | 2019 |
Attenuation of Inflammation and Leptin Resistance by Pyrogallol-Phloroglucinol-6,6-Bieckol on in the Brain of Obese Animal Models.
Topics: Adipose Tissue; Animals; Brain; Diet; Disease Models, Animal; Eating; Endoplasmic Reticulum Stress; | 2019 |
Phloroglucinol prevents albumin glycation as well as diminishes ROS production, glycooxidative damage, nitrosative stress and inflammation in hepatocytes treated with high glucose.
Topics: Albumins; Antioxidants; Ascorbic Acid; Glucose; Glycation End Products, Advanced; Guanidines; Hep G2 | 2021 |
A Novel Synthetic Derivative of Phloroglucinol Inhibits Neuroinflammatory Responses Through Attenuating Kalirin Signaling Pathway in Murine BV2 Microglial Cells.
Topics: Animals; Cell Line; Enzyme Activation; Guanine Nucleotide Exchange Factors; Inflammation; Lipopolysa | 2019 |
LC-MS
Topics: Anti-Inflammatory Agents; Antineoplastic Agents; Biological Assay; Cell Line; Cell Survival; Chromat | 2019 |
Protective effect of phlorotannins from Eisenia bicyclis against lipopolysaccharide-stimulated inflammation in HepG2 cells.
Topics: Anti-Inflammatory Agents; Cell Survival; Cyclooxygenase 2; Cytokines; Hep G2 Cells; Humans; Inflamma | 2013 |
Alleviation of behavioral hypersensitivity in mouse models of inflammatory pain with two structurally different casein kinase 1 (CK1) inhibitors.
Topics: Animals; Carrageenan; Casein Kinase I; Cells, Cultured; Disease Models, Animal; Enzyme Inhibitors; E | 2014 |
Characterization of atopic skin and the effect of a hyperforin-rich cream by laser scanning microscopy.
Topics: Administration, Cutaneous; Cosmetics; Dermatitis, Atopic; Humans; Inflammation; Lipids; Microscopy, | 2015 |
Phloroglucinol protects the urinary bladder via inhibition of oxidative stress and inflammation in a rat model of cyclophosphamide-induced interstitial cystitis.
Topics: Animals; Cyclophosphamide; Cystitis, Interstitial; Female; Inflammation; Oxidative Stress; Phloroglu | 2015 |
Hypericum perforatum Reduces Paracetamol-Induced Hepatotoxicity and Lethality in Mice by Modulating Inflammation and Oxidative Stress.
Topics: Acetaminophen; Alanine Transaminase; Animals; Anthracenes; Anti-Inflammatory Agents; Antioxidants; A | 2015 |
In vitro antiproliferative, pro-apoptotic, antimetastatic and anti-inflammatory potential of 2,4-diacetylphloroglucinol (DAPG) by Pseudomonas aeruginosa strain FP10.
Topics: Animals; Antineoplastic Agents; Apoptosis; Apoptosis Regulatory Proteins; Cell Line; Cell Line, Tumo | 2015 |
Investigation of antibacterial activity of aspidin BB against Propionibacterium acnes.
Topics: Acne Vulgaris; Anti-Bacterial Agents; Bacterial Proteins; Cell Membrane Permeability; DNA Fragmentat | 2016 |
Gastrointestinal modifications and bioavailability of brown seaweed phlorotannins and effects on inflammatory markers.
Topics: Adolescent; Adult; Aged; Biological Availability; Biomarkers; Chromatography, High Pressure Liquid; | 2016 |
Barrier protective effects of 2,4,6-trihydroxy-3-geranyl acetophenone on lipopolysaccharides-stimulated inflammatory responses in human umbilical vein endothelial cells.
Topics: Acetophenones; Actin Cytoskeleton; Anti-Inflammatory Agents; Capillary Permeability; Cell Adhesion; | 2016 |
Protective effect of phloroglucinol against myocardial ischaemia-reperfusion injury is related to inhibition of myeloperoxidase activity and inflammatory cell infiltration.
Topics: Animals; Apoptosis; Cardiotonic Agents; Drug Evaluation, Preclinical; Enzyme Inhibitors; Inflammatio | 2011 |
Barrier protective activities of phloroglucinol on lipopolysaccharide (LPS)-induced barrier disruption in human endothelial cells.
Topics: Cell Adhesion; Cell Membrane Permeability; Cell Movement; Cells, Cultured; E-Selectin; Human Umbilic | 2012 |
Vascular barrier protective effects of phlorotannins on HMGB1-mediated proinflammatory responses in vitro and in vivo.
Topics: Animals; Benzofurans; Blood Vessels; Blotting, Western; Cell Adhesion Molecules; Cell Membrane Perme | 2012 |
Hyperforin blocks neutrophil activation of matrix metalloproteinase-9, motility and recruitment, and restrains inflammation-triggered angiogenesis and lung fibrosis.
Topics: Animals; Anti-Inflammatory Agents; Bridged Bicyclo Compounds; Cell Movement; Chemotaxis, Leukocyte; | 2007 |