phloroglucinol has been researched along with Glioblastoma in 8 studies
Phloroglucinol: A trinitrobenzene derivative with antispasmodic properties that is used primarily as a laboratory reagent.
phloroglucinol : A benzenetriol with hydroxy groups at position 1, 3 and 5.
Glioblastoma: A malignant form of astrocytoma histologically characterized by pleomorphism of cells, nuclear atypia, microhemorrhage, and necrosis. They may arise in any region of the central nervous system, with a predilection for the cerebral hemispheres, basal ganglia, and commissural pathways. Clinical presentation most frequently occurs in the fifth or sixth decade of life with focal neurologic signs or seizures.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Glioblastoma is the most common primary brain tumor with poor survival rate and without effective treatment strategy." | 5.56 | Hyperforin induces apoptosis through extrinsic/intrinsic pathways and inhibits EGFR/ERK/NF-κB-mediated anti-apoptotic potential in glioblastoma. ( Chen, WT; Chung, JG; Hsu, FT; Wu, CT, 2020) |
| "This review focuses on a carotenoid and a phlorotannin present in seaweed, namely fucoxanthin and phloroglucinol, and their anticancer activity against glioblastoma." | 4.98 | Drug resistance in glioblastoma and cytotoxicity of seaweed compounds, alone and in combination with anticancer drugs: A mini review. ( Almeida, T; Azqueta, A; Ferreira, J; Ramos, AA; Rocha, E, 2018) |
| " John's wort (SJW) extract] modulates VEGF expression, possible relationship between≤μM hyperforin (Hyp, the bioactive component in SJW) and VEGF in CNS tumours has been now examined in medulloblastoma and glioblastoma cells." | 3.77 | Antidepressant hyperforin up-regulates VEGF in CNS tumour cells. ( Bradaschia, A; Garbisa, S; Maran, C; Masola, V; Onisto, M; Tassone, E, 2011) |
| "Glioma is the foremost recurrent type of brain tumor in humans; in particular, glioblastoma (GBM) is the main form of brain tumor (GBM) that is highly proliferative and impervious to apoptosis." | 1.72 | Triphlorethol-A attenuates U251 human glioma cancer cell proliferation and ameliorates apoptosis through JAK2/STAT3 and p38 MAPK/ERK signaling pathways. ( Ganesan, S; Jiang, B; Li, W; Su, Z; Wu, A; Yang, Z; Yuan, Z, 2022) |
| "Glioblastoma is the most common primary brain tumor with poor survival rate and without effective treatment strategy." | 1.56 | Hyperforin induces apoptosis through extrinsic/intrinsic pathways and inhibits EGFR/ERK/NF-κB-mediated anti-apoptotic potential in glioblastoma. ( Chen, WT; Chung, JG; Hsu, FT; Wu, CT, 2020) |
| "The difficulty in treating glioblastoma is largely attributed to the lack of effective therapeutic targets." | 1.48 | Casein Kinase 1 Epsilon Regulates Glioblastoma Cell Survival. ( Guo, S; Kelly, DF; Liang, Y; Murphy, S; Pham, L; Pridham, KJ; Sheng, Z; Varghese, RT; Young, S, 2018) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (12.50) | 29.6817 |
| 2010's | 5 (62.50) | 24.3611 |
| 2020's | 2 (25.00) | 2.80 |
| Authors | Studies |
|---|---|
| Yuan, Z | 1 |
| Yang, Z | 1 |
| Li, W | 1 |
| Wu, A | 1 |
| Su, Z | 1 |
| Jiang, B | 1 |
| Ganesan, S | 1 |
| Hsu, FT | 1 |
| Chen, WT | 1 |
| Wu, CT | 1 |
| Chung, JG | 1 |
| Ferreira, J | 1 |
| Ramos, AA | 1 |
| Almeida, T | 1 |
| Azqueta, A | 1 |
| Rocha, E | 1 |
| Varghese, RT | 1 |
| Young, S | 1 |
| Pham, L | 1 |
| Liang, Y | 1 |
| Pridham, KJ | 1 |
| Guo, S | 1 |
| Murphy, S | 1 |
| Kelly, DF | 1 |
| Sheng, Z | 1 |
| Keksel, N | 1 |
| Bussmann, H | 1 |
| Unger, M | 1 |
| Drewe, J | 1 |
| Boonen, G | 1 |
| Häberlein, H | 3 |
| Franken, S | 1 |
| Jakobs, D | 1 |
| Hage-Hülsmann, A | 1 |
| Prenner, L | 2 |
| Kolb, C | 1 |
| Weiser, D | 2 |
| Tassone, E | 1 |
| Maran, C | 1 |
| Masola, V | 1 |
| Bradaschia, A | 1 |
| Garbisa, S | 1 |
| Onisto, M | 1 |
| Sieben, A | 1 |
| Zeller, K | 1 |
1 review available for phloroglucinol and Glioblastoma
| Article | Year |
|---|---|
Drug resistance in glioblastoma and cytotoxicity of seaweed compounds, alone and in combination with anticancer drugs: A mini review.
Topics: Antineoplastic Agents, Alkylating; Apoptosis; Brain Neoplasms; Dacarbazine; Drug Resistance, Neoplas | 2018 |
7 other studies available for phloroglucinol and Glioblastoma
| Article | Year |
|---|---|
Triphlorethol-A attenuates U251 human glioma cancer cell proliferation and ameliorates apoptosis through JAK2/STAT3 and p38 MAPK/ERK signaling pathways.
Topics: Antioxidants; Apoptosis; bcl-2-Associated X Protein; Brain Neoplasms; Caspases; Cell Line, Tumor; Ce | 2022 |
Hyperforin induces apoptosis through extrinsic/intrinsic pathways and inhibits EGFR/ERK/NF-κB-mediated anti-apoptotic potential in glioblastoma.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Apoptosis Regulatory Proteins; Brain Neoplasms; Cell L | 2020 |
Casein Kinase 1 Epsilon Regulates Glioblastoma Cell Survival.
Topics: Animals; beta Catenin; Casein Kinase I; Cell Line, Tumor; Cell Survival; Glioblastoma; Humans; Indol | 2018 |
St John's wort extract influences membrane fluidity and composition of phosphatidylcholine and phosphatidylethanolamine in rat C6 glioblastoma cells.
Topics: Animals; Anthracenes; Cell Line, Tumor; Cell Membrane; Glioblastoma; Hydrocortisone; Hypericum; Memb | 2019 |
Downregulation of β1 -adrenergic receptors in rat C6 glioblastoma cells by hyperforin and hyperoside from St John's wort.
Topics: Animals; Cell Line, Tumor; Cell Membrane; Cyclic AMP; Down-Regulation; Glioblastoma; Hypericum; Phlo | 2013 |
Antidepressant hyperforin up-regulates VEGF in CNS tumour cells.
Topics: Antidepressive Agents; Apoptosis; Brain Neoplasms; Bridged Bicyclo Compounds; Cell Line, Tumor; Cell | 2011 |
Reduction of high-affinity beta2-adrenergic receptor binding by hyperforin and hyperoside on rat C6 glioblastoma cells measured by fluorescence correlation spectroscopy.
Topics: Animals; Brain Neoplasms; Bridged Bicyclo Compounds; Cell Line, Tumor; Cyclic AMP; Glioblastoma; Hum | 2007 |