phloroglucinol has been researched along with Disease Models, Animal in 35 studies
Phloroglucinol: A trinitrobenzene derivative with antispasmodic properties that is used primarily as a laboratory reagent.
phloroglucinol : A benzenetriol with hydroxy groups at position 1, 3 and 5.
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The cuprizone-induced model was used in this study to mimic the pathological progress of MS." | 5.56 | Phloroglucinol derivative compound 21 attenuates cuprizone-induced multiple sclerosis mice through promoting remyelination and inhibiting neuroinflammation. ( Bao, XQ; Liu, H; Zhang, D; Zhang, Z; Zhao, Z, 2020) |
| "Rats treated with phloroglucinol had increased serum testosterone, NO and sperm count." | 5.51 | Potential of phloroglucinol to improve erectile dysfunction associated with streptozotocin-induced diabetes in rats. ( Illuri, R; Kashif, S; Razdan, R, 2019) |
| "Clinical data indicate that hydroalcoholic extracts of Hypericum perforatum might be as valuable as conventional antidepressants in mild-to-moderate depression, with fewer side effects." | 4.82 | The antidepressant mechanism of Hypericum perforatum. ( Gobbi, M; Mennini, T, 2004) |
| "Photodynamic therapy with hypericin (HY-PDT) and hyperforin (HP) could be treatment modalities for colorectal cancer (CRC), but evidence of their effect on angiogenic factors in CRC is missing." | 3.91 | Novel Insights into the Effect of Hyperforin and Photodynamic Therapy with Hypericin on Chosen Angiogenic Factors in Colorectal Micro-Tumors Created on Chorioallantoic Membrane. ( Babinčák, M; Buríková, M; Fedoročko, P; Jendželovská, Z; Jendželovský, R; Košuth, J; Majerník, M; Ševc, J; Tonelli Gombalová, Z, 2019) |
| " The role played by its components, particularly hypericin and hyperforin, has been examined in different experimental models of depression." | 3.72 | Hypericum perforatum subspecies angustifolium shows a protective activity on the consequences of unavoidable stress exposure at lower doses than Hypericum perforatum perforatum. ( De Montis, MG; Gambarana, C; Giachetti, D; Grappi, S; Leggio, B; Nanni, G; Tolu, P; Usai, M, 2003) |
| " Interactions of constituents, tested in bioavailability models, may explain why synergistic mechanisms have been found to be important for antidepressant and antiproliferative bioactivities." | 2.50 | Evidence for contributions of interactions of constituents to the anti-inflammatory activity of Hypericum perforatum. ( Birt, DF; Hammer, KD, 2014) |
| "Hyperforin has been shown to inhibit, like conventional antidepressants, the neuronal uptake of serotonin, norepinephrine and dopamine." | 2.42 | Role of hyperforin in the pharmacological activities of St. John's Wort. ( Zanoli, P, 2004) |
| "The cuprizone-induced model was used in this study to mimic the pathological progress of MS." | 1.56 | Phloroglucinol derivative compound 21 attenuates cuprizone-induced multiple sclerosis mice through promoting remyelination and inhibiting neuroinflammation. ( Bao, XQ; Liu, H; Zhang, D; Zhang, Z; Zhao, Z, 2020) |
| "Rats treated with phloroglucinol had increased serum testosterone, NO and sperm count." | 1.51 | Potential of phloroglucinol to improve erectile dysfunction associated with streptozotocin-induced diabetes in rats. ( Illuri, R; Kashif, S; Razdan, R, 2019) |
| "Hyperforin (0." | 1.48 | Hyperforin protects against acute cerebral ischemic injury through inhibition of interleukin-17A-mediated microglial activation. ( Liu, K; Ma, L; Pan, X; Wang, L; Zhou, F, 2018) |
| "Phloroglucinol is a polyphenol component of phlorotannin, which is found at sufficient levels in Ecklonia cava (E." | 1.48 | Phloroglucinol ameliorates cognitive impairments by reducing the amyloid β peptide burden and pro-inflammatory cytokines in the hippocampus of 5XFAD mice. ( Chang, MJ; Cho, JY; Choi, M; Choi, Y; Hyun, JW; Kim, H; Kim, HS; Kim, YS; Lee, JP; Mahmood, U; Yang, EJ, 2018) |
| "tHGA's effect on airway remodeling could be attributed to the reduction of inflammatory cell infiltration and decreased expression of cytokines associated with airway remodeling." | 1.46 | An orally active geranyl acetophenone attenuates airway remodeling in a murine model of chronic asthma. ( Cheema, MS; Israf, DA; Lee, YZ; Shaari, K; Sulaiman, MR; Tham, CL, 2017) |
| "Hyperforin (Hyp) is an active compound contained in the extract of Hypericum perforatum, well known for its antidepressant activity." | 1.35 | Hyperforin down-regulates effector function of activated T lymphocytes and shows efficacy against Th1-triggered CNS inflammatory-demyelinating disease. ( Agostini, C; Brunetta, E; Cabrelle, A; Calzà, L; Carraro, S; D'Intino, G; Dell'Aica, I; Garbisa, S; Melchiori, L; Niero, R; Scquizzato, E, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 9 (25.71) | 29.6817 |
| 2010's | 24 (68.57) | 24.3611 |
| 2020's | 2 (5.71) | 2.80 |
| Authors | Studies |
|---|---|
| Zhao, Z | 1 |
| Bao, XQ | 2 |
| Zhang, Z | 1 |
| Liu, H | 1 |
| Zhang, D | 2 |
| Choi, J | 2 |
| Oh, S | 2 |
| Son, M | 2 |
| Byun, K | 2 |
| Jang, JT | 1 |
| Choi, CH | 1 |
| Park, KY | 1 |
| Son, KH | 1 |
| Taveau, N | 1 |
| Cubizolle, A | 1 |
| Guillou, L | 1 |
| Pinquier, N | 1 |
| Moine, E | 1 |
| Cia, D | 1 |
| Kalatzis, V | 1 |
| Vercauteren, J | 1 |
| Durand, T | 1 |
| Crauste, C | 1 |
| Brabet, P | 1 |
| Ma, L | 1 |
| Pan, X | 1 |
| Zhou, F | 1 |
| Liu, K | 1 |
| Wang, L | 1 |
| Geng, YN | 1 |
| Wu, YJ | 1 |
| Zhang, WX | 1 |
| Yang, EJ | 2 |
| Mahmood, U | 1 |
| Kim, H | 1 |
| Choi, M | 1 |
| Choi, Y | 1 |
| Lee, JP | 1 |
| Cho, JY | 1 |
| Hyun, JW | 2 |
| Kim, YS | 1 |
| Chang, MJ | 2 |
| Kim, HS | 2 |
| Jiang, X | 1 |
| Kumar, M | 1 |
| Zhu, Y | 1 |
| Kashif, S | 1 |
| Razdan, R | 1 |
| Illuri, R | 1 |
| Majerník, M | 1 |
| Jendželovský, R | 1 |
| Babinčák, M | 1 |
| Košuth, J | 1 |
| Ševc, J | 1 |
| Tonelli Gombalová, Z | 1 |
| Jendželovská, Z | 1 |
| Buríková, M | 1 |
| Fedoročko, P | 1 |
| Carvajal, FJ | 2 |
| Zolezzi, JM | 1 |
| Tapia-Rojas, C | 2 |
| Godoy, JA | 1 |
| Inestrosa, NC | 5 |
| Brenn, A | 1 |
| Grube, M | 1 |
| Jedlitschky, G | 1 |
| Fischer, A | 1 |
| Strohmeier, B | 1 |
| Eiden, M | 1 |
| Keller, M | 1 |
| Groschup, MH | 1 |
| Vogelgesang, S | 1 |
| Centurião, FB | 1 |
| Braga, A | 1 |
| Machado, FR | 1 |
| Tagliari, B | 1 |
| Müller, LG | 1 |
| Kolling, J | 1 |
| Poser, Gv | 1 |
| Wyse, AT | 1 |
| Rates, SM | 1 |
| Hofrichter, J | 1 |
| Krohn, M | 1 |
| Schumacher, T | 1 |
| Lange, C | 1 |
| Feistel, B | 1 |
| Walbroel, B | 1 |
| Heinze, HJ | 1 |
| Crockett, S | 1 |
| Sharbel, TF | 1 |
| Pahnke, J | 1 |
| Hammer, KD | 1 |
| Birt, DF | 1 |
| Kurihara, T | 1 |
| Sakurai, E | 1 |
| Toyomoto, M | 1 |
| Kii, I | 1 |
| Kawamoto, D | 1 |
| Asada, T | 1 |
| Tanabe, T | 1 |
| Yoshimura, M | 1 |
| Hagiwara, M | 1 |
| Miyata, A | 1 |
| Liu, Y | 1 |
| Liu, C | 1 |
| Qin, X | 1 |
| Zhu, M | 1 |
| Yang, Z | 1 |
| Ahn, S | 1 |
| Ryu, J | 1 |
| Choi, MS | 1 |
| Choi, S | 1 |
| Chong, YH | 1 |
| Fracasso, C | 1 |
| Bagnati, R | 1 |
| Passoni, A | 1 |
| Guiso, G | 1 |
| Cantoni, L | 1 |
| Riva, A | 2 |
| Morazzoni, P | 3 |
| Gobbi, M | 2 |
| Nosratabadi, R | 1 |
| Rastin, M | 1 |
| Sankian, M | 1 |
| Haghmorad, D | 1 |
| Tabasi, N | 1 |
| Zamani, S | 1 |
| Aghaee, A | 1 |
| Salehipour, Z | 1 |
| Mahmoudi, M | 1 |
| Wang, YD | 1 |
| Xu, S | 1 |
| Yu, WW | 1 |
| Cao, SN | 1 |
| Hu, JP | 1 |
| Li, Y | 1 |
| Wang, XL | 1 |
| Yu, SS | 1 |
| Lee, YZ | 1 |
| Shaari, K | 1 |
| Cheema, MS | 1 |
| Tham, CL | 1 |
| Sulaiman, MR | 1 |
| Israf, DA | 1 |
| Cerpa, W | 2 |
| Hancke, JL | 3 |
| Bombardelli, E | 1 |
| Marin, PP | 1 |
| Griffith, TN | 1 |
| Benito, MJ | 1 |
| Rivera-Dictter, A | 1 |
| Alvarez, AR | 1 |
| Serrano, FG | 1 |
| Burgos, PV | 1 |
| Parodi, J | 1 |
| Varela-Nallar, L | 2 |
| Carillo, BA | 1 |
| Oliveira-Sales, EB | 1 |
| Andersen, M | 1 |
| Tufik, S | 1 |
| Hipolide, D | 1 |
| Santos, AA | 1 |
| Tucci, PJ | 1 |
| Bergamaschi, CT | 1 |
| Campos, RR | 1 |
| Abbott, AC | 1 |
| Calderon Toledo, C | 1 |
| Aranguiz, FC | 1 |
| Usai, M | 1 |
| Leggio, B | 1 |
| Grappi, S | 1 |
| Nanni, G | 1 |
| Gambarana, C | 2 |
| Tolu, P | 1 |
| Giachetti, D | 2 |
| De Montis, MG | 2 |
| Mennini, T | 1 |
| Zanoli, P | 1 |
| Dinamarca, MC | 1 |
| Garrido, J | 1 |
| Singha, PK | 1 |
| Roy, S | 1 |
| Dey, S | 1 |
| do Rego, JC | 1 |
| Benkiki, N | 1 |
| Chosson, E | 1 |
| Kabouche, Z | 1 |
| Seguin, E | 1 |
| Costentin, J | 1 |
| Butterweck, V | 1 |
| Schmidt, M | 1 |
| Cabrelle, A | 1 |
| Dell'Aica, I | 1 |
| Melchiori, L | 1 |
| Carraro, S | 1 |
| Brunetta, E | 1 |
| Niero, R | 1 |
| Scquizzato, E | 1 |
| D'Intino, G | 1 |
| Calzà, L | 1 |
| Garbisa, S | 1 |
| Agostini, C | 1 |
| Tolu, PL | 1 |
| Masi, F | 1 |
| Rinaldi, M | 1 |
4 reviews available for phloroglucinol and Disease Models, Animal
| Article | Year |
|---|---|
Evidence for contributions of interactions of constituents to the anti-inflammatory activity of Hypericum perforatum.
Topics: Animals; Anti-Inflammatory Agents; Biflavonoids; Disease Models, Animal; Flavonoids; Humans; Hyperic | 2014 |
The antidepressant mechanism of Hypericum perforatum.
Topics: Animals; Anthracenes; Bridged Bicyclo Compounds; Depression; Disease Models, Animal; Hypericum; Neur | 2004 |
Role of hyperforin in the pharmacological activities of St. John's Wort.
Topics: Animals; Antidepressive Agents; Bridged Bicyclo Compounds; Clinical Trials as Topic; Depression; Dis | 2004 |
St. John's wort: role of active compounds for its mechanism of action and efficacy.
Topics: Animals; Anthracenes; Antidepressive Agents; Bridged Bicyclo Compounds; Cells, Cultured; Clinical Tr | 2007 |
31 other studies available for phloroglucinol and Disease Models, Animal
| Article | Year |
|---|---|
Phloroglucinol derivative compound 21 attenuates cuprizone-induced multiple sclerosis mice through promoting remyelination and inhibiting neuroinflammation.
Topics: Animals; Astrocytes; Brain; Cuprizone; Cytokines; Disease Models, Animal; Drug Discovery; Inflammati | 2020 |
Pyrogallol-Phloroglucinol-6,6-Bieckol Alleviates Obesity and Systemic Inflammation in a Mouse Model by Reducing Expression of RAGE and RAGE Ligands.
Topics: Animals; Anti-Obesity Agents; Cytokines; Diet; Dioxins; Disease Models, Animal; Hypertrophy; Inflamm | 2019 |
Attenuation of Inflammation and Leptin Resistance by Pyrogallol-Phloroglucinol-6,6-Bieckol on in the Brain of Obese Animal Models.
Topics: Adipose Tissue; Animals; Brain; Diet; Disease Models, Animal; Eating; Endoplasmic Reticulum Stress; | 2019 |
Preclinical pharmacology of a lipophenol in a mouse model of light-induced retinopathy.
Topics: Animals; cis-trans-Isomerases; Disease Models, Animal; Disease Susceptibility; Docosahexaenoic Acids | 2020 |
Hyperforin protects against acute cerebral ischemic injury through inhibition of interleukin-17A-mediated microglial activation.
Topics: Animals; Brain Infarction; Brain Injuries; Cytokines; Disease Models, Animal; Exploratory Behavior; | 2018 |
[Effect of hyperforin on learning and memory abilities and Aβ₁₋₄₂, βAPP and BACE1 protein expressions in hippocampus of Alzheimer's disease model mice].
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Amyloid Precursor Protein | 2016 |
Phloroglucinol ameliorates cognitive impairments by reducing the amyloid β peptide burden and pro-inflammatory cytokines in the hippocampus of 5XFAD mice.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Cognitive Dysfunction; Disease Models, Animal; Hi | 2018 |
Protective Effect of Hyperforin on β Amyloid Protein Induced Apoptosis in PC12 Cells and Colchicine Induced Alzheimer's Disease: An Anti-oxidant and Anti-inflammatory Therapy.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Animals; Antioxidants; Apoptosis; Co | 2018 |
Potential of phloroglucinol to improve erectile dysfunction associated with streptozotocin-induced diabetes in rats.
Topics: Animals; Blood Pressure; Diabetes Mellitus, Experimental; Disease Models, Animal; Erectile Dysfuncti | 2019 |
Novel Insights into the Effect of Hyperforin and Photodynamic Therapy with Hypericin on Chosen Angiogenic Factors in Colorectal Micro-Tumors Created on Chorioallantoic Membrane.
Topics: Angiogenesis Inducing Agents; Animals; Anthracenes; Biomarkers; Cell Line, Tumor; Chick Embryo; Chor | 2019 |
Tetrahydrohyperforin decreases cholinergic markers associated with amyloid-β plaques, 4-hydroxynonenal formation, and caspase-3 activation in AβPP/PS1 mice.
Topics: Aldehydes; Alzheimer Disease; Animals; Brain; Caspase 3; Disease Models, Animal; Enzyme Activation; | 2013 |
St. John's Wort reduces beta-amyloid accumulation in a double transgenic Alzheimer's disease mouse model-role of P-glycoprotein.
Topics: Alzheimer Disease; Amyloid; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Brain; | 2014 |
Study of antidepressant-like activity of an enriched phloroglucinol fraction obtained from Hypericum caprifoliatum.
Topics: Animals; Antidepressive Agents; Cerebral Cortex; Depression; Disease Models, Animal; Hippocampus; Hy | 2014 |
Reduced Alzheimer's disease pathology by St. John's Wort treatment is independent of hyperforin and facilitated by ABCC1 and microglia activation in mice.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Brain; Disease Mo | 2013 |
Alleviation of behavioral hypersensitivity in mouse models of inflammatory pain with two structurally different casein kinase 1 (CK1) inhibitors.
Topics: Animals; Carrageenan; Casein Kinase I; Cells, Cultured; Disease Models, Animal; Enzyme Inhibitors; E | 2014 |
The change of spatial cognition ability in depression rat model and the possible association with down-regulated protein expression of TRPC6.
Topics: Animals; Body Weight; Central Nervous System Agents; Cognition; Cognition Disorders; Dendrites; Depr | 2015 |
Phloroglucinol Attenuates the Cognitive Deficits of the 5XFAD Mouse Model of Alzheimer's Disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Cell Line; Cognition; Dendritic Spines; Disease M | 2015 |
Brain Uptake of Tetrahydrohyperforin and Potential Metabolites after Repeated Dosing in Mice.
Topics: Alzheimer Disease; Animals; Brain; Chromatography, High Pressure Liquid; Disease Models, Animal; Hip | 2015 |
St. John's wort and its component hyperforin alleviate experimental autoimmune encephalomyelitis through expansion of regulatory T-cells.
Topics: Animals; Cell Proliferation; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Fe | 2016 |
A Novel Parkinson's Disease Drug Candidate with Potent Anti-neuroinflammatory Effects through the Src Signaling Pathway.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Anti-Inflammatory Agents; Disease Models, Ani | 2016 |
An orally active geranyl acetophenone attenuates airway remodeling in a murine model of chronic asthma.
Topics: Acetophenones; Administration, Oral; Airway Remodeling; Animals; Anti-Asthmatic Agents; Asthma; Chro | 2017 |
The hyperforin derivative IDN5706 occludes spatial memory impairments and neuropathological changes in a double transgenic Alzheimer's mouse model.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Astrocytes; Brain; Bridged Bicyclo Compounds; Dis | 2010 |
Tetrahydrohyperforin prevents cognitive deficit, Aβ deposition, tau phosphorylation and synaptotoxicity in the APPswe/PSEN1ΔE9 model of Alzheimer's disease: a possible effect on APP processing.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Disease Models, A | 2011 |
Changes in GABAergic inputs in the paraventricular nucleus maintain sympathetic vasomotor tone in chronic heart failure.
Topics: Animals; Autoradiography; Blood Pressure; Disease Models, Animal; Dizocilpine Maleate; Echocardiogra | 2012 |
Tetrahydrohyperforin increases adult hippocampal neurogenesis in wild-type and APPswe/PS1ΔE9 mice.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Antipsychotic Agents; Bromodeoxyuridine; | 2013 |
Hypericum perforatum subspecies angustifolium shows a protective activity on the consequences of unavoidable stress exposure at lower doses than Hypericum perforatum perforatum.
Topics: Animals; Antidepressive Agents; Bridged Bicyclo Compounds; Depression; Disease Models, Animal; Dose- | 2003 |
Hyperforin prevents beta-amyloid neurotoxicity and spatial memory impairments by disaggregation of Alzheimer's amyloid-beta-deposits.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloidosis; Analysis of Variance; Animals; Bridged Bicycl | 2006 |
Protective activity of andrographolide and arabinogalactan proteins from Andrographis paniculata Nees. against ethanol-induced toxicity in mice.
Topics: Acid Phosphatase; Alkaline Phosphatase; Andrographis; Animals; Aspartate Aminotransferases; Central | 2007 |
Antidepressant-like effect of hyperfoliatin, a polyisoprenylated phloroglucinol derivative from Hypericum perfoliatum (Clusiaceae) is associated with an inhibition of neuronal monoamines uptake.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Depression; Disease Models, Animal; Dopamine; Dose | 2007 |
Hyperforin down-regulates effector function of activated T lymphocytes and shows efficacy against Th1-triggered CNS inflammatory-demyelinating disease.
Topics: Animals; Bridged Bicyclo Compounds; Cell Survival; Disease Models, Animal; Down-Regulation; Encephal | 2008 |
A study of the antidepressant activity of Hypericum perforatum on animal models.
Topics: Animals; Antidepressive Agents; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tri | 2001 |