phloroglucinol has been researched along with Depressive Disorder, Major in 2 studies
Phloroglucinol: A trinitrobenzene derivative with antispasmodic properties that is used primarily as a laboratory reagent.
phloroglucinol : A benzenetriol with hydroxy groups at position 1, 3 and 5.
Depressive Disorder, Major: Disorder in which five (or more) of the following symptoms have been present during the same 2-week period and represent a change from previous functioning; at least one of the symptoms is either (1) depressed mood or (2) loss of interest or pleasure. Symptoms include: depressed mood most of the day, nearly every daily; markedly diminished interest or pleasure in activities most of the day, nearly every day; significant weight loss when not dieting or weight gain; Insomnia or hypersomnia nearly every day; psychomotor agitation or retardation nearly every day; fatigue or loss of energy nearly every day; feelings of worthlessness or excessive or inappropriate guilt; diminished ability to think or concentrate, or indecisiveness, nearly every day; or recurrent thoughts of death, recurrent suicidal ideation without a specific plan, or a suicide attempt. (DSM-5)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Hypericum extracts have been regarded as antidepressant drugs without specific side effects by patients, medical professionals and researchers alike." | 2.42 | Safety of Hypericum extract in mildly to moderately depressed outpatients: a review based on data from three randomized, placebo-controlled trials. ( Dienel, A; Trautmann-Sponsel, RD, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Trautmann-Sponsel, RD | 1 |
| Dienel, A | 1 |
| Vitiello, B | 1 |
| Shader, RI | 1 |
| Parker, CB | 1 |
| Ritz, L | 1 |
| Harlan, W | 1 |
| Greenblatt, DJ | 1 |
| Gadde, KM | 1 |
| Krishnan, KR | 1 |
| Davidson, JR | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Placebo Controlled Clinical Trial of a Standardized Extract of Hypericum Perforatum in Major Depressive Disorder[NCT00005013] | 0 participants | Interventional | 1998-12-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for phloroglucinol and Depressive Disorder, Major
| Article | Year |
|---|---|
Safety of Hypericum extract in mildly to moderately depressed outpatients: a review based on data from three randomized, placebo-controlled trials.
Topics: Antidepressive Agents; Bridged Bicyclo Compounds; Depressive Disorder, Major; Dose-Response Relation | 2004 |
1 trial available for phloroglucinol and Depressive Disorder, Major
| Article | Year |
|---|---|
Hyperforin plasma level as a marker of treatment adherence in the National Institutes of Health Hypericum Depression Trial.
Topics: Adult; Biomarkers; Bridged Bicyclo Compounds; Chi-Square Distribution; Depressive Disorder, Major; D | 2005 |