phloroglucinol has been researched along with Depression in 25 studies
Phloroglucinol: A trinitrobenzene derivative with antispasmodic properties that is used primarily as a laboratory reagent.
phloroglucinol : A benzenetriol with hydroxy groups at position 1, 3 and 5.
Depression: Depressive states usually of moderate intensity in contrast with MAJOR DEPRESSIVE DISORDER present in neurotic and psychotic disorders.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Using the keywords [St John's Wort OR Hypericum perforatum OR hypericin OR hyperforin OR johanniskraut OR] AND [depression OR antidepressant OR SSRI], a preliminary search (without language restriction) on the PubMed, Ovid, Clinical Trials Register of the Cochrane Collaboration Depression, Anxiety and Neurosis Group, Cochrane Field for Complementary Medicine, China National Knowledge Infrastructure and WanFang database yielded 5428 papers between 1-Jan-1960 and 1-May-2016." | 8.95 | Clinical use of Hypericum perforatum (St John's wort) in depression: A meta-analysis. ( Ho, CY; Ng, QX; Venkatanarayanan, N, 2017) |
| "Using the keywords [St John's Wort OR Hypericum perforatum OR hypericin OR hyperforin OR johanniskraut OR] AND [depression OR antidepressant OR SSRI], a preliminary search (without language restriction) on the PubMed, Ovid, Clinical Trials Register of the Cochrane Collaboration Depression, Anxiety and Neurosis Group, Cochrane Field for Complementary Medicine, China National Knowledge Infrastructure and WanFang database yielded 5428 papers between 1-Jan-1960 and 1-May-2016." | 4.95 | Clinical use of Hypericum perforatum (St John's wort) in depression: A meta-analysis. ( Ho, CY; Ng, QX; Venkatanarayanan, N, 2017) |
| "The recent clinical studies on hypericum extract support the present indications for its use in mild to moderate depression and depressive episodes." | 4.84 | [New developments in hypericum extracts: data on efficacy and interactions]. ( Kraft, K, 2007) |
| "Hypericum perforatum (St John's Wort [SJW]) counts among the most favourite herbal drugs, and is the only herbal alternative to classic synthetic antidepressants in the therapy of mild to moderate depression." | 4.83 | Hypericum perforatum: a 'modern' herbal antidepressant: pharmacokinetics of active ingredients. ( Schubert-Zsilavecz, M; Wurglics, M, 2006) |
| "Clinical data indicate that hydroalcoholic extracts of Hypericum perforatum might be as valuable as conventional antidepressants in mild-to-moderate depression, with fewer side effects." | 4.82 | The antidepressant mechanism of Hypericum perforatum. ( Gobbi, M; Mennini, T, 2004) |
| " The herb Hypericum perforatum (St John's wort) might offer another approach to the treatment of depression." | 4.81 | St John's wort: Prozac from the plant kingdom. ( Borrelli, F; Di Carlo, G; Ernst, E; Izzo, AA, 2001) |
| " John's wort plant (Hypericum perforatum) is commonly used to treat mild to moderate depression." | 3.79 | Hyperforin modulates dendritic spine morphology in hippocampal pyramidal neurons by activating Ca(2+) -permeable TRPC6 channels. ( Amaral, MD; Calfa, G; Harteneck, C; Inoue, T; Leuner, K; Li, W; Pozzo-Miller, L; Rudolph, S; Schuwald, AM, 2013) |
| " The role played by its components, particularly hypericin and hyperforin, has been examined in different experimental models of depression." | 3.72 | Hypericum perforatum subspecies angustifolium shows a protective activity on the consequences of unavoidable stress exposure at lower doses than Hypericum perforatum perforatum. ( De Montis, MG; Gambarana, C; Giachetti, D; Grappi, S; Leggio, B; Nanni, G; Tolu, P; Usai, M, 2003) |
| "Studies of St." | 2.43 | St. John's wort. ( Lawvere, S; Mahoney, MC, 2005) |
| "Hyperforin has been shown to inhibit, like conventional antidepressants, the neuronal uptake of serotonin, norepinephrine and dopamine." | 2.42 | Role of hyperforin in the pharmacological activities of St. John's Wort. ( Zanoli, P, 2004) |
| "As hypericin has been found to bind to LDL one may assume that it can act as antioxidant of LDL lipid oxidation, a property which is of prophylactic/therapeutic interest regarding atherogenesis as LDL oxidation may play a pivotal role in the onset of atherosclerosis." | 1.34 | The main components of St John's Wort inhibit low-density lipoprotein atherogenic modification: a beneficial "side effect" of an OTC antidepressant drug? ( Exner, M; Gmeiner, BM; Hermann, M; Kapiotis, S; Laggner, H; Mühl, A; Schreier, S, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (8.00) | 18.2507 |
| 2000's | 15 (60.00) | 29.6817 |
| 2010's | 7 (28.00) | 24.3611 |
| 2020's | 1 (4.00) | 2.80 |
| Authors | Studies |
|---|---|
| Wang, S | 2 |
| Wang, Y | 1 |
| Xin, Y | 1 |
| Zhang, J | 1 |
| Yang, Z | 1 |
| Liu, C | 1 |
| Soleymani, S | 1 |
| Bahramsoltani, R | 1 |
| Rahimi, R | 1 |
| Abdollahi, M | 1 |
| Zhang, Y | 1 |
| Yu, P | 1 |
| Liu, H | 1 |
| Yao, H | 1 |
| Yao, S | 1 |
| Yuan, SY | 1 |
| Zhang, JC | 1 |
| Szewczyk, B | 1 |
| Pochwat, B | 1 |
| Muszyńska, B | 1 |
| Opoka, W | 1 |
| Krakowska, A | 1 |
| Rafało-Ulińska, A | 1 |
| Friedland, K | 1 |
| Nowak, G | 1 |
| Russo, E | 1 |
| Scicchitano, F | 1 |
| Whalley, BJ | 1 |
| Mazzitello, C | 1 |
| Ciriaco, M | 1 |
| Esposito, S | 1 |
| Patanè, M | 1 |
| Upton, R | 1 |
| Pugliese, M | 1 |
| Chimirri, S | 1 |
| Mammì, M | 1 |
| Palleria, C | 1 |
| De Sarro, G | 1 |
| Centurião, FB | 1 |
| Braga, A | 1 |
| Machado, FR | 1 |
| Tagliari, B | 1 |
| Müller, LG | 1 |
| Kolling, J | 1 |
| Poser, Gv | 1 |
| Wyse, AT | 1 |
| Rates, SM | 1 |
| Ng, QX | 1 |
| Venkatanarayanan, N | 1 |
| Ho, CY | 1 |
| Leuner, K | 2 |
| Li, W | 1 |
| Amaral, MD | 1 |
| Rudolph, S | 1 |
| Calfa, G | 1 |
| Schuwald, AM | 1 |
| Harteneck, C | 2 |
| Inoue, T | 1 |
| Pozzo-Miller, L | 1 |
| Verotta, L | 1 |
| Usai, M | 1 |
| Leggio, B | 1 |
| Grappi, S | 1 |
| Nanni, G | 1 |
| Gambarana, C | 2 |
| Tolu, P | 1 |
| Giachetti, D | 2 |
| De Montis, MG | 2 |
| Mennini, T | 2 |
| Gobbi, M | 2 |
| Capasso, R | 1 |
| Borrelli, F | 2 |
| Capasso, F | 1 |
| Mascolo, N | 1 |
| Izzo, AA | 2 |
| Zanoli, P | 1 |
| Lawvere, S | 1 |
| Mahoney, MC | 1 |
| Wurglics, M | 1 |
| Schubert-Zsilavecz, M | 1 |
| Laggner, H | 1 |
| Schreier, S | 1 |
| Hermann, M | 1 |
| Exner, M | 1 |
| Mühl, A | 1 |
| Gmeiner, BM | 1 |
| Kapiotis, S | 1 |
| do Rego, JC | 1 |
| Benkiki, N | 1 |
| Chosson, E | 1 |
| Kabouche, Z | 1 |
| Seguin, E | 1 |
| Costentin, J | 1 |
| Kazanski, V | 1 |
| Müller, M | 1 |
| Essin, K | 1 |
| Henke, B | 1 |
| Gollasch, M | 1 |
| Müller, WE | 1 |
| Kraft, K | 1 |
| Biron, CR | 1 |
| Vormfelde, SV | 1 |
| Poser, W | 1 |
| Morazzoni, P | 2 |
| Di Carlo, G | 1 |
| Ernst, E | 1 |
| Tolu, PL | 1 |
| Masi, F | 1 |
| Rinaldi, M | 1 |
10 reviews available for phloroglucinol and Depression
| Article | Year |
|---|---|
Clinical risks of St John's Wort (Hypericum perforatum) co-administration.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cytochrome P-450 Enzyme System; De | 2017 |
Hypericum perforatum: pharmacokinetic, mechanism of action, tolerability, and clinical drug-drug interactions.
Topics: Anthracenes; Antidepressive Agents; Antiviral Agents; Depression; Herb-Drug Interactions; Humans; Hy | 2014 |
Clinical use of Hypericum perforatum (St John's wort) in depression: A meta-analysis.
Topics: Anthracenes; Antidepressive Agents; Depression; Humans; Hypericum; Perylene; Phloroglucinol; Phytoth | 2017 |
Hypericum perforatum, a source of neuroactive lead structures.
Topics: Bridged Bicyclo Compounds; Chromatography, High Pressure Liquid; Depression; Humans; Hypericum; Mass | 2003 |
The antidepressant mechanism of Hypericum perforatum.
Topics: Animals; Anthracenes; Bridged Bicyclo Compounds; Depression; Disease Models, Animal; Hypericum; Neur | 2004 |
Role of hyperforin in the pharmacological activities of St. John's Wort.
Topics: Animals; Antidepressive Agents; Bridged Bicyclo Compounds; Clinical Trials as Topic; Depression; Dis | 2004 |
St. John's wort.
Topics: Anthracenes; Antidepressive Agents; Bridged Bicyclo Compounds; Depression; Humans; Hypericum; Peryle | 2005 |
Hypericum perforatum: a 'modern' herbal antidepressant: pharmacokinetics of active ingredients.
Topics: Animals; Anthracenes; Antidepressive Agents; Bridged Bicyclo Compounds; Clinical Trials as Topic; De | 2006 |
[New developments in hypericum extracts: data on efficacy and interactions].
Topics: Adolescent; Adult; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Bridg | 2007 |
St John's wort: Prozac from the plant kingdom.
Topics: Adrenergic Uptake Inhibitors; Animals; Antidepressive Agents; Biological Availability; Bridged Bicyc | 2001 |
15 other studies available for phloroglucinol and Depression
| Article | Year |
|---|---|
Hyperforin alleviates the psychiatric disorders of adult rats suffered from early maternal separation via activating autophagy.
Topics: Animals; Anti-Anxiety Agents; Antidepressive Agents; Anxiety; Autophagy; Beclin-1; Depression; Disks | 2021 |
Hyperforin improves post-stroke social isolation‑induced exaggeration of PSD and PSA via TGF-β.
Topics: Animals; Anxiety; Behavior, Animal; Brain Ischemia; Depression; Hippocampus; Male; Mice, Inbred C57B | 2019 |
Antidepressant-like activity of hyperforin and changes in BDNF and zinc levels in mice exposed to chronic unpredictable mild stress.
Topics: Animals; Antidepressive Agents; Brain-Derived Neurotrophic Factor; Depression; Depressive Disorder; | 2019 |
Study of antidepressant-like activity of an enriched phloroglucinol fraction obtained from Hypericum caprifoliatum.
Topics: Animals; Antidepressive Agents; Cerebral Cortex; Depression; Disease Models, Animal; Hippocampus; Hy | 2014 |
Hyperforin modulates dendritic spine morphology in hippocampal pyramidal neurons by activating Ca(2+) -permeable TRPC6 channels.
Topics: Animals; Calcium; Calcium Channel Blockers; Dendritic Spines; Depression; Gene Expression; Hippocamp | 2013 |
Hypericum perforatum subspecies angustifolium shows a protective activity on the consequences of unavoidable stress exposure at lower doses than Hypericum perforatum perforatum.
Topics: Animals; Antidepressive Agents; Bridged Bicyclo Compounds; Depression; Disease Models, Animal; Dose- | 2003 |
Inhibitory effect of the antidepressant St. John's wort (hypericum perforatum) on rat bladder contractility in vitro.
Topics: Acetylcholine; Adenosine Triphosphate; Animals; Anthracenes; Antidepressive Agents; Atropine; Bridge | 2004 |
The main components of St John's Wort inhibit low-density lipoprotein atherogenic modification: a beneficial "side effect" of an OTC antidepressant drug?
Topics: Anthracenes; Antidepressive Agents; Antioxidants; Atherosclerosis; Bridged Bicyclo Compounds; Cells, | 2007 |
Antidepressant-like effect of hyperfoliatin, a polyisoprenylated phloroglucinol derivative from Hypericum perfoliatum (Clusiaceae) is associated with an inhibition of neuronal monoamines uptake.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Depression; Disease Models, Animal; Dopamine; Dose | 2007 |
Hyperforin--a key constituent of St. John's wort specifically activates TRPC6 channels.
Topics: Animals; Bridged Bicyclo Compounds; Calcium; Cell Line; Depression; Gene Expression Regulation; Huma | 2007 |
[Therapy of mild to medium degree depression].
Topics: Anthracenes; Antidepressive Agents; Bridged Bicyclo Compounds; Depression; Depressive Disorder; Huma | 1998 |
St. John's Wort: is it effective and harmless?
Topics: Antidepressive Agents; Bridged Bicyclo Compounds; Clinical Trials as Topic; Depression; Humans; Hype | 1999 |
Hyperforin in extracts of St John's wort (Hypericum perforatum) for depression.
Topics: Anti-Bacterial Agents; Bridged Bicyclo Compounds; Depression; Humans; Hypericum; Phloroglucinol; Phy | 2000 |
St John's Wort and literature quotations.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Brain Chemistry; Bridged Bicyclo Compounds; | 2001 |
A study of the antidepressant activity of Hypericum perforatum on animal models.
Topics: Animals; Antidepressive Agents; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tri | 2001 |