phloroglucinol has been researched along with Cancer of Colon in 12 studies
Phloroglucinol: A trinitrobenzene derivative with antispasmodic properties that is used primarily as a laboratory reagent.
phloroglucinol : A benzenetriol with hydroxy groups at position 1, 3 and 5.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The hypericin and hyperforin effect has been described to understand the signal mechanisms that stimulate or stunt cancer cell sprouting to metastasis on colon adenocarcinoma cells HT-29 and its resistant form HT-29-OxR." | 7.88 | The potential of hypericin and hyperforin for antiadhesion therapy to prevent metastasis of parental and oxaliplatin-resistant human adenocarcinoma cells (HT-29). ( Fedoročko, P; Sačková, V; Šemeláková, M, 2018) |
| " The hypericin and hyperforin effect has been described to understand the signal mechanisms that stimulate or stunt cancer cell sprouting to metastasis on colon adenocarcinoma cells HT-29 and its resistant form HT-29-OxR." | 3.88 | The potential of hypericin and hyperforin for antiadhesion therapy to prevent metastasis of parental and oxaliplatin-resistant human adenocarcinoma cells (HT-29). ( Fedoročko, P; Sačková, V; Šemeláková, M, 2018) |
| "However, their functions in colon cancer and the underlying mechanism remain unclear." | 1.56 | IC261, a specific inhibitor of CK1δ/ε, promotes aerobic glycolysis through p53-dependent mechanisms in colon cancer. ( Chang, H; Hu, Y; Jia, H; Li, J; Liu, M; Lu, M; Lu, S; Ren, F; Zhong, J; Zhou, M, 2020) |
| " In combination with 5-Fu, Fx at 10 µM (in HCT116 and HT29 cells), and Ph at 300 µM (in HT29 cells) enhanced the cytotoxic effect of 5-Fu; however, no marked cytotoxicity was noted in CCD-18Co cells." | 1.46 | Anticancer effects of seaweed compounds fucoxanthin and phloroglucinol, alone and in combination with 5-fluorouracil in colon cells. ( Abreu, M; Gargiulo, D; Lopes-Costa, E; Ramos, AA; Rocha, E, 2017) |
| "Treatment with phloroglucinol significantly inhibited the expression of Ras, Raf, mitogen-activated protein kinase (MEK), extracellular-signal regulated kinase (ERK) phosphorylation, PI3K and Akt." | 1.40 | Phloroglucinol induces apoptosis through the regulation of insulin-like growth factor 1 receptor signaling pathways in human colon cancer HT-29 cells. ( Kang, MH; Kim, IH; Nam, TJ, 2014) |
| "Phloroglucinol treatment of HT-29 cells resulted in characteristic apoptosis-related changes: altered Bcl-2 family proteins, cytochrome c release, and activation of caspase-3 and caspase-8." | 1.40 | Phloroglucinol induces apoptosis via apoptotic signaling pathways in HT-29 colon cancer cells. ( Kang, MH; Kim, IH; Nam, TJ, 2014) |
| "Treatment of HCT-116 human colon cancer cells with MCPP was found to induce a number of signature endoplasmic reticulum (ER) stress markers; and up-regulation of CCAAT/enhancer-binding protein homologous protein (CHOP) and glucose-regulated protein (GRP)-78, phosphorylation of eukaryotic initiation factor-2α (eIF-2α), suggesting the induction of ER stress." | 1.37 | Phloroglucinol derivative MCPP induces cell apoptosis in human colon cancer. ( Chang, CS; Chen, JH; Cheung, CW; Huang, SM; Ko, SH; Lin, YH; Liu, JF; Lu, DY; Tang, CH; Wong, KL, 2011) |
| "Hyperforin is considered to be a primary cause of the inductive effect of St." | 1.33 | Functional induction and de-induction of P-glycoprotein by St. John's wort and its ingredients in a human colon adenocarcinoma cell line. ( Koyabu, N; Morimoto, S; Ohtani, H; Sawada, Y; Shoyama, Y; Tian, R, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (16.67) | 29.6817 |
| 2010's | 7 (58.33) | 24.3611 |
| 2020's | 3 (25.00) | 2.80 |
| Authors | Studies |
|---|---|
| Knauthe, A | 1 |
| Mittag, S | 1 |
| Bloch, L | 1 |
| Albring, KF | 1 |
| Schmidt, M | 1 |
| Werz, O | 1 |
| Huber, O | 1 |
| Jiang, NN | 1 |
| Gar-Lee Yue, G | 1 |
| Li, P | 1 |
| Ye, YS | 1 |
| Gomes, AJ | 1 |
| Hin-Fai Kwok, F | 1 |
| Kin-Ming Lee, J | 1 |
| Gao, S | 1 |
| Lau, CB | 1 |
| Xu, G | 1 |
| Liu, M | 1 |
| Hu, Y | 1 |
| Lu, S | 1 |
| Lu, M | 1 |
| Li, J | 1 |
| Chang, H | 1 |
| Jia, H | 1 |
| Zhou, M | 1 |
| Ren, F | 1 |
| Zhong, J | 1 |
| Lopes-Costa, E | 1 |
| Abreu, M | 1 |
| Gargiulo, D | 1 |
| Rocha, E | 1 |
| Ramos, AA | 1 |
| Šemeláková, M | 3 |
| Sačková, V | 1 |
| Fedoročko, P | 3 |
| Kang, MH | 2 |
| Kim, IH | 2 |
| Nam, TJ | 2 |
| Jendželovský, R | 2 |
| Huang, SM | 1 |
| Cheung, CW | 1 |
| Chang, CS | 1 |
| Tang, CH | 1 |
| Liu, JF | 1 |
| Lin, YH | 1 |
| Chen, JH | 1 |
| Ko, SH | 1 |
| Wong, KL | 1 |
| Lu, DY | 1 |
| Mikeš, J | 1 |
| Donà, M | 1 |
| Dell'Aica, I | 1 |
| Pezzato, E | 1 |
| Sartor, L | 1 |
| Calabrese, F | 1 |
| Della Barbera, M | 1 |
| Donella-Deana, A | 1 |
| Appendino, G | 1 |
| Borsarini, A | 1 |
| Caniato, R | 1 |
| Garbisa, S | 1 |
| Tian, R | 1 |
| Koyabu, N | 1 |
| Morimoto, S | 1 |
| Shoyama, Y | 1 |
| Ohtani, H | 1 |
| Sawada, Y | 1 |
12 other studies available for phloroglucinol and Cancer of Colon
| Article | Year |
|---|---|
Hyperforin and Myrtucommulone Derivatives Act as Natural Modulators of Wnt/β-Catenin Signaling in HCT116 Colon Cancer Cells.
Topics: beta Catenin; Colonic Neoplasms; HCT116 Cells; Humans; Hypericum; Phloroglucinol; Terpenes; Wnt Sign | 2022 |
Discovery of dearomatized isoprenylated acylphloroglucinols with colon tumor suppressive activities in mice via inhibiting NFκB-FAT1-PDCD4 signaling activation.
Topics: Animals; Antineoplastic Agents; Apoptosis Regulatory Proteins; Cadherins; Cell Line, Tumor; Colonic | 2022 |
IC261, a specific inhibitor of CK1δ/ε, promotes aerobic glycolysis through p53-dependent mechanisms in colon cancer.
Topics: Apoptosis; Blotting, Western; Casein Kinase 1 epsilon; Casein Kinase Idelta; Cell Line, Tumor; Cell | 2020 |
Anticancer effects of seaweed compounds fucoxanthin and phloroglucinol, alone and in combination with 5-fluorouracil in colon cells.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents; Blotting, Western; Cell Survival; Colon; Col | 2017 |
The potential of hypericin and hyperforin for antiadhesion therapy to prevent metastasis of parental and oxaliplatin-resistant human adenocarcinoma cells (HT-29).
Topics: Adenocarcinoma; Anthracenes; Antineoplastic Combined Chemotherapy Protocols; Cell Adhesion; Cell Mov | 2018 |
Phloroglucinol induces apoptosis through the regulation of insulin-like growth factor 1 receptor signaling pathways in human colon cancer HT-29 cells.
Topics: Antineoplastic Agents; Apoptosis; Cell Cycle; Cell Proliferation; Colonic Neoplasms; Gene Expression | 2014 |
Phloroglucinol induces apoptosis via apoptotic signaling pathways in HT-29 colon cancer cells.
Topics: Adenocarcinoma; Animals; Apoptosis; Caspase 3; Caspase 8; Cell Line; Cell Proliferation; Cell Surviv | 2014 |
Drug membrane transporters and CYP3A4 are affected by hypericin, hyperforin or aristoforin in colon adenocarcinoma cells.
Topics: Adenocarcinoma; Anthracenes; Blotting, Western; Cell Line, Tumor; Colonic Neoplasms; Cytochrome P-45 | 2016 |
Phloroglucinol derivative MCPP induces cell apoptosis in human colon cancer.
Topics: Apoptosis; Caco-2 Cells; Cell Line, Tumor; Colonic Neoplasms; Endoplasmic Reticulum Chaperone BiP; F | 2011 |
The pro-apoptotic and anti-invasive effects of hypericin-mediated photodynamic therapy are enhanced by hyperforin or aristoforin in HT-29 colon adenocarcinoma cells.
Topics: Adenocarcinoma; Anthracenes; Antineoplastic Agents; Apoptosis; Caspase 3; Cell Cycle Checkpoints; Ce | 2012 |
Hyperforin inhibits cancer invasion and metastasis.
Topics: Adenocarcinoma; Animals; Apoptosis; Bridged Bicyclo Compounds; Cell Division; Cell Survival; Colonic | 2004 |
Functional induction and de-induction of P-glycoprotein by St. John's wort and its ingredients in a human colon adenocarcinoma cell line.
Topics: Adenocarcinoma; Animals; Anthracenes; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biolo | 2005 |