phloroglucinol has been researched along with Alzheimer Disease in 20 studies
Phloroglucinol: A trinitrobenzene derivative with antispasmodic properties that is used primarily as a laboratory reagent.
phloroglucinol : A benzenetriol with hydroxy groups at position 1, 3 and 5.
Alzheimer Disease: A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention span, and problem solving skills are followed by severe APRAXIAS and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of SENILE PLAQUES; NEUROFIBRILLARY TANGLES; and NEUROPIL THREADS. (From Adams et al., Principles of Neurology, 6th ed, pp1049-57)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Phloroglucinol is a polyphenol component of phlorotannin, which is found at sufficient levels in Ecklonia cava (E." | 1.48 | Phloroglucinol ameliorates cognitive impairments by reducing the amyloid β peptide burden and pro-inflammatory cytokines in the hippocampus of 5XFAD mice. ( Chang, MJ; Cho, JY; Choi, M; Choi, Y; Hyun, JW; Kim, H; Kim, HS; Kim, YS; Lee, JP; Mahmood, U; Yang, EJ, 2018) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (10.00) | 29.6817 |
| 2010's | 16 (80.00) | 24.3611 |
| 2020's | 2 (10.00) | 2.80 |
| Authors | Studies |
|---|---|
| Jang, BG | 1 |
| Choi, B | 1 |
| Kim, S | 1 |
| Lee, DS | 1 |
| Lee, J | 1 |
| Koh, YH | 1 |
| Jo, SA | 1 |
| Kim, JE | 1 |
| Kang, TC | 1 |
| Kim, MJ | 1 |
| Yang, EJ | 3 |
| Kim, H | 2 |
| Kim, HS | 3 |
| Chang, MJ | 3 |
| Geng, YN | 1 |
| Wu, YJ | 1 |
| Zhang, WX | 1 |
| Jiang, CS | 1 |
| Wang, YY | 1 |
| Song, JT | 1 |
| Yu, JH | 1 |
| Mahmood, U | 1 |
| Choi, M | 1 |
| Choi, Y | 1 |
| Lee, JP | 1 |
| Cho, JY | 1 |
| Hyun, JW | 2 |
| Kim, YS | 1 |
| Guo, Y | 1 |
| Zhang, N | 1 |
| Sun, W | 1 |
| Duan, X | 1 |
| Zhang, Q | 1 |
| Zhou, Q | 1 |
| Chen, C | 1 |
| Zhu, H | 1 |
| Luo, Z | 1 |
| Liu, J | 1 |
| Li, XN | 1 |
| Xue, Y | 1 |
| Zhang, Y | 1 |
| Jiang, X | 1 |
| Kumar, M | 1 |
| Zhu, Y | 1 |
| Carvajal, FJ | 2 |
| Zolezzi, JM | 1 |
| Tapia-Rojas, C | 2 |
| Godoy, JA | 1 |
| Inestrosa, NC | 7 |
| Brenn, A | 1 |
| Grube, M | 1 |
| Jedlitschky, G | 1 |
| Fischer, A | 1 |
| Strohmeier, B | 1 |
| Eiden, M | 1 |
| Keller, M | 1 |
| Groschup, MH | 1 |
| Vogelgesang, S | 1 |
| Hofrichter, J | 1 |
| Krohn, M | 1 |
| Schumacher, T | 1 |
| Lange, C | 1 |
| Feistel, B | 1 |
| Walbroel, B | 1 |
| Heinze, HJ | 1 |
| Crockett, S | 1 |
| Sharbel, TF | 1 |
| Pahnke, J | 1 |
| Montecinos-Oliva, C | 1 |
| Schuller, A | 1 |
| Parodi, J | 2 |
| Melo, F | 1 |
| Ahn, S | 1 |
| Ryu, J | 1 |
| Choi, MS | 1 |
| Choi, S | 1 |
| Chong, YH | 1 |
| Fracasso, C | 1 |
| Bagnati, R | 1 |
| Passoni, A | 1 |
| Guiso, G | 1 |
| Cantoni, L | 1 |
| Riva, A | 2 |
| Morazzoni, P | 2 |
| Gobbi, M | 1 |
| Cerpa, W | 2 |
| Hancke, JL | 3 |
| Bombardelli, E | 1 |
| Marin, PP | 1 |
| Griffith, TN | 2 |
| Varela-Nallar, L | 3 |
| Dinamarca, MC | 2 |
| Abuznait, AH | 1 |
| Cain, C | 1 |
| Ingram, D | 1 |
| Burk, D | 1 |
| Kaddoumi, A | 1 |
| Benito, MJ | 1 |
| Rivera-Dictter, A | 1 |
| Alvarez, AR | 1 |
| Serrano, FG | 1 |
| Burgos, PV | 1 |
| Abbott, AC | 1 |
| Calderon Toledo, C | 1 |
| Aranguiz, FC | 1 |
| Li, G | 1 |
| Yin, H | 1 |
| Kuret, J | 1 |
| Garrido, J | 1 |
1 review available for phloroglucinol and Alzheimer Disease
| Article | Year |
|---|---|
Neurobiological effects of Hyperforin and its potential in Alzheimer's disease therapy.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Antidepressive Agents; Bridged Bicyclo Compounds; | 2010 |
19 other studies available for phloroglucinol and Alzheimer Disease
| Article | Year |
|---|---|
2,4-Diacetylphloroglucinol Reduces Beta-Amyloid Production and Secretion by Regulating ADAM10 and Intracellular Trafficking in Cellular and Animal Models of Alzheimer's Disease.
Topics: ADAM10 Protein; Alzheimer Disease; Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Anim | 2022 |
Phloroglucinol attenuates oligomeric amyloid beta peptide
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Astrocytes; Cells, Cultured; Central Nervous Syst | 2021 |
[Effect of hyperforin on learning and memory abilities and Aβ₁₋₄₂, βAPP and BACE1 protein expressions in hippocampus of Alzheimer's disease model mice].
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Amyloid Precursor Protein | 2016 |
Acylphloroglucinols as kinase inhibitors from
Topics: Alzheimer Disease; Cyclin-Dependent Kinase 5; Glycogen Synthase Kinase 3; Humans; Magnetic Resonance | 2019 |
Phloroglucinol ameliorates cognitive impairments by reducing the amyloid β peptide burden and pro-inflammatory cytokines in the hippocampus of 5XFAD mice.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Cognitive Dysfunction; Disease Models, Animal; Hi | 2018 |
Bioactive polycyclic polyprenylated acylphloroglucinols from Hypericum perforatum.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid Precursor Protein Secretases; Aspartic Acid Endopep | 2018 |
Protective Effect of Hyperforin on β Amyloid Protein Induced Apoptosis in PC12 Cells and Colchicine Induced Alzheimer's Disease: An Anti-oxidant and Anti-inflammatory Therapy.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Animals; Antioxidants; Apoptosis; Co | 2018 |
Tetrahydrohyperforin decreases cholinergic markers associated with amyloid-β plaques, 4-hydroxynonenal formation, and caspase-3 activation in AβPP/PS1 mice.
Topics: Aldehydes; Alzheimer Disease; Animals; Brain; Caspase 3; Disease Models, Animal; Enzyme Activation; | 2013 |
St. John's Wort reduces beta-amyloid accumulation in a double transgenic Alzheimer's disease mouse model-role of P-glycoprotein.
Topics: Alzheimer Disease; Amyloid; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Brain; | 2014 |
Reduced Alzheimer's disease pathology by St. John's Wort treatment is independent of hyperforin and facilitated by ABCC1 and microglia activation in mice.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Brain; Disease Mo | 2013 |
Effects of tetrahydrohyperforin in mouse hippocampal slices: neuroprotection, long-term potentiation and TRPC channels.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Behavior, Animal; Binding Sites; Diglycerides; Ex | 2014 |
Phloroglucinol Attenuates the Cognitive Deficits of the 5XFAD Mouse Model of Alzheimer's Disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Cell Line; Cognition; Dendritic Spines; Disease M | 2015 |
Brain Uptake of Tetrahydrohyperforin and Potential Metabolites after Repeated Dosing in Mice.
Topics: Alzheimer Disease; Animals; Brain; Chromatography, High Pressure Liquid; Disease Models, Animal; Hip | 2015 |
The hyperforin derivative IDN5706 occludes spatial memory impairments and neuropathological changes in a double transgenic Alzheimer's mouse model.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Astrocytes; Brain; Bridged Bicyclo Compounds; Dis | 2010 |
Up-regulation of P-glycoprotein reduces intracellular accumulation of beta amyloid: investigation of P-glycoprotein as a novel therapeutic target for Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; ATP Binding Cassette Transporter, Subfamily B, Member 1; C | 2011 |
Tetrahydrohyperforin prevents cognitive deficit, Aβ deposition, tau phosphorylation and synaptotoxicity in the APPswe/PSEN1ΔE9 model of Alzheimer's disease: a possible effect on APP processing.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Disease Models, A | 2011 |
Tetrahydrohyperforin increases adult hippocampal neurogenesis in wild-type and APPswe/PS1ΔE9 mice.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Antipsychotic Agents; Bromodeoxyuridine; | 2013 |
Casein kinase 1 delta phosphorylates tau and disrupts its binding to microtubules.
Topics: Alzheimer Disease; Casein Kinases; Cell Line; Humans; Indoles; Microtubules; Phloroglucinol; Phospho | 2004 |
Hyperforin prevents beta-amyloid neurotoxicity and spatial memory impairments by disaggregation of Alzheimer's amyloid-beta-deposits.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloidosis; Analysis of Variance; Animals; Bridged Bicycl | 2006 |