Page last updated: 2024-08-16

phlorhizin and Hyperglycemia, Postprandial

phlorhizin has been researched along with Hyperglycemia, Postprandial in 64 studies

Research

Studies (64)

Timeframe	Studies, this research(%)	All Research%
pre-1990	19 (29.69)	18.7374
1990's	12 (18.75)	18.2507
2000's	13 (20.31)	29.6817
2010's	20 (31.25)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Chang, CC; Chao, YS; Chen, CT; Chiu, CH; Chu, KF; Hsiao, WC; Hsieh, CJ; Hsieh, TC; Huang, CY; Hung, MS; Lee, JC; Liu, YW; Song, JS; Tsai, CH; Wang, MH; Wu, SH; Yao, CH; Yeh, TK; Yuan, MC	1
Fujikura, H; Fushimi, N; Isaji, M; Ishikawa-Takemura, Y; Itoh, F; Kamada, N; Kobayashi, S; Miyagi, T; Nakabayashi, T; Ohno, K; Ozawa, T; Shibazaki, T; Shimizu, K; Shiohara, H; Teranishi, H; Tomae, M; Yonekubo, S	1
Kakehashi, A; Kemmochi, Y; Maekawa, T; Motohashi, Y; Ohta, T; Sasase, T; Tadaki, H; Tanaka, Y; Yamada, T	1
Cegieła, U; Folwarczna, J; Janas, A; Londzin, P; Pytlik, M; Siudak, S; Waligóra, A	1
Chen, LJ; Cheng, JT; Cheng, MF; Hsu, CT; Wang, MC	1
Abcouwer, SF; Fort, PE; Gardner, TW; Jefferson, LS; Kimball, SR; Losiewicz, MK; Pennathur, S	1
Cirule, H; Dambrova, M; Górnaś, P; Gulbe, A; Konrade, I; Makarova, E; Pugajeva, I; Seglina, D; Tirzite, D	1
Kakimoto, K; Katsuda, Y; Kemmochi, Y; Kume, S; Mera, Y; Motohashi, Y; Ohta, T; Sasase, T; Tadaki, H; Toyoda, K	1
Harada, S; Tokuyama, S; Yamazaki, Y	2
Chino, Y; Fukasawa, Y; Hachiuma, K; Hasegawa, M; Horiuchi, N; Ishida, M; Nakai, Y; Yamaguchi, J	1
Cho, SJ; Choi, MS; Jung, UJ; Ryu, R; Shin, SK	1
Barberis, A; Bazzu, G; Cardinali, A; D'Antuono, I; D'Hallewin, G; Fadda, A; Garbetta, A; Linsalata, V; Minervini, F; Rocchitta, G; Serra, PA	1
Thomson, SC; Vallon, V	1
Chang, CK; Cheng, JT; Cheng, KC; Juang, SW; Kou, DH; Liu, IM; Tong, YC	1
Lin, K; Wang, PH; Yang, JY; Yeh, HY	1
Altirriba, J; Barbera, A; Del Zotto, H; Gagliardino, JJ; Gomis, R; Nadal, B; Piquer, S; Sánchez-Pla, A	1
Ito, J; Mashiko, S; Moriya, R; Seo, T; Shirakura, T	1
DRABKIN, DL; MARSH, JB	2
Mather, A; Pollock, C	1
Bronson, SK; Dennis, MD; Jefferson, LS; Kimball, SR; Schrufer, TL	1
Balteau, M; Beauloye, C; Bertrand, L; Brady, NR; de Meester, C; Des Rosiers, C; Gailly, P; Ginion, A; Horman, S; Hue, L; Sommereyns, C; Tajeddine, N; Vanoverschelde, JL	1
Abcouwer, SF; Barber, AJ; Fort, PE; Gardner, TW; Losiewicz, MK; Nakamura, M; Reiter, CE; Singh, RS	1
Abbruscato, T; Snyder, R; Thekkumkara, T; Yesudas, R	1
Fukazawa, M; Honda, K; Ikeda, S; Kato, M; Kawabe, Y; Kawai, M; Mitsui, T; Murao, N; Nagata, T; Suzuki, Y; Yamaguchi, K; Yamane, M; Yata, T	1
Efendic, S; Gaisano, HY; Ostenson, CG; Sheu, L; Wheeler, MB	1
Abrahani, A; Allard, M; Brownsey, R; Chan, N; Ghosh, S; Kulpa, J; Pulinilkunnil, T; Rodrigues, B; Tang, I; Varghese, J	1
BECKETT, SB; ELLIS, S	1
Gavrilova, O; Jou, W; Kim, H; LeRoith, D; Setser, J; Sun, H; Yakar, S; Zhang, Y; Zhao, H	1
Alford, FP; Christopher, MJ; Kemp, BE; McConell, G; Rantzau, C	1
Bronson, SK; Gardner, TW; Hong, EG; Jun, JY; Jung, DY; Kim, JH; Kim, JK; Ko, HJ; Ma, Z; Sumner, AD; Vary, TC; Zhang, Z	1
Anhê, GF; Bordin, S; Freitas, HS; Machado, UF; Melo, KF; Okamoto, MM; Oliveira-Souza, M	1
Csáky, TZ; Fischer, E	1
Fischer, E; Lauterbach, F	1
Annabi, B; Dimitrakoudis, D; Klip, A; Lavoie, L; Marette, A; van de Werve, G; Vranic, M	1
de Gimeno, MA; Franchi, AM; Gonzalez, ET; Jawerbaum, A; Novaro, V	1
Barzilai, N; Chen, W; Hu, M; Massillon, D; Rossetti, L	1
Mizuno, A; Noma, Y; Sano, T; Shima, K; Zhu, M	1
Kim, JK; Wi, JK; Youn, JH	1
Buongiorno, A; Giaccari, A; Maroccia, E; Morviducci, L; Pastore, L; Sbraccia, P; Tamburrano, G; Zorretta, D	1
Andersson, A; Carlsson, PO; Jansson, L	1
Kuwajima, M; Murakami, T; Ogino, T; Shima, K; Zhu, M	1
Fujimiya, M; Fujita, Y; Hidaka, H; Kashiwagi, A; Kikkawa, R; Kojima, H	1
Bonner-Weir, S; Hasenkamp, W; Ilkova, H; Jonas, JC; Laybutt, R; Patanè, G; Sharma, A; Weir, GC	1
Efendic, S; Hong-Lie, C; Khan, A; Ling, ZC; Ostenson, CG	1
Bonner-Weir, S; Grey, S; Groff, A; Hasenkamp, W; Jonas, JC; Kaneto, H; Laybutt, R; Sharma, A; Weir, G	1
Dong, J; Fillmore, JJ; Kahn, BB; Kahn, CR; Kim, JK; Kotani, K; Peroni, OD; Perret, P; Shulman, GI; Zisman, A; Zong, H	1
Dimitrakoudis, D; Klip, A; Vranic, M	1
Bell, GI; DeSautel, SL; Kayano, T; Pessin, JE; Sivitz, WI	1
Lauglin, MR; Rossetti, L	1
DeFronzo, RA; Rossetti, L; Shulman, GI; Zawalich, W	1
Helderman, JH; Imamura, T; Koffler, M; Santeusanio, F	1
DeFronzo, RA; Papachristou, D; Rossetti, L; Shulman, GI; Smith, D	1
Esteller, A; González, J; Muñoz, ME; Villanueva, GR	1
Grundy, S; McGarry, JD; Starke, A; Unger, RH	1
Flynn, FW; Grill, HJ	1
Hellman, B; Lernmark, A; Sehlin, J; Täljedal, IB	2
Hellman, B; Idahl, LA; Lernmark, A; Sehlin, J; Simon, E; Täljedal, IB	1
Hellman, B; Sehlin, J; Täljedal, IB	3
Burtis, CA; Goetsch, GD; Jackson, HD; Packett, LV	1

Reviews

3 review(s) available for phlorhizin and Hyperglycemia, Postprandial

Article	Year
Targeting renal glucose reabsorption to treat hyperglycaemia: the pleiotropic effects of SGLT2 inhibition. Diabetologia, 2017, Volume: 60, Issue:2 Topics: Diabetes Mellitus, Type 2; Glucose; Humans; Hyperglycemia; Insulin Resistance; Kidney; Phlorhizin; Sodium-Glucose Transporter 2; Sodium-Glucose Transporter 2 Inhibitors	2017
Renal glucose transporters: novel targets for hyperglycemia management. Nature reviews. Nephrology, 2010, Volume: 6, Issue:5 Topics: Animals; Biological Availability; Biological Transport; Diabetic Nephropathies; Glomerular Filtration Rate; Glucose; Humans; Hyperglycemia; Hypoglycemic Agents; Kidney; Phlorhizin; Sodium-Glucose Transporter 2; Sodium-Glucose Transporter 2 Inhibitors	2010
Effects of hyperglycemia on glucose transporters of the muscle: use of the renal glucose reabsorption inhibitor phlorizin to control glycemia. Journal of the American Society of Nephrology : JASN, 1992, Volume: 3, Issue:5 Topics: Animals; Binding, Competitive; Blood Glucose; Cytochalasin B; Diabetes Complications; Diabetes Mellitus; Diabetes Mellitus, Experimental; Gene Expression Regulation; Glucose Transporter Type 4; Glycosylation; Humans; Hyperglycemia; Insulin; Insulin Resistance; Intestinal Absorption; Kidney Tubules, Proximal; Monosaccharide Transport Proteins; Multigene Family; Muscle Proteins; Muscles; Organ Specificity; Phlorhizin; Rats; Subcellular Fractions	1992

Trials

1 trial(s) available for phlorhizin and Hyperglycemia, Postprandial

Article	Year
Acute anti-hyperglycaemic effects of an unripe apple preparation containing phlorizin in healthy volunteers: a preliminary study. Journal of the science of food and agriculture, 2015, Volume: 95, Issue:3 Topics: Blood Glucose; Dietary Fiber; Dietary Sucrose; Female; Fruit; Glucose Tolerance Test; Healthy Volunteers; Humans; Hyperglycemia; Hypoglycemic Agents; Malus; Pectins; Phlorhizin; Plant Extracts; Polyphenols; Postprandial Period; Powders; Reference Values	2015

Article

Year

Acute anti-hyperglycaemic effects of an unripe apple preparation containing phlorizin in healthy volunteers: a preliminary study.

Journal of the science of food and agriculture, 2015, Volume: 95, Issue:3

Topics: Blood Glucose; Dietary Fiber; Dietary Sucrose; Female; Fruit; Glucose Tolerance Test; Healthy Volunteers; Humans; Hyperglycemia; Hypoglycemic Agents; Malus; Pectins; Phlorhizin; Plant Extracts; Polyphenols; Postprandial Period; Powders; Reference Values

2015

Other Studies

60 other study(ies) available for phlorhizin and Hyperglycemia, Postprandial

Article	Year
Discovery of novel N-β-D-xylosylindole derivatives as sodium-dependent glucose cotransporter 2 (SGLT2) inhibitors for the management of hyperglycemia in diabetes. Journal of medicinal chemistry, 2011, Jan-13, Volume: 54, Issue:1 Topics: Animals; CHO Cells; Cricetinae; Cricetulus; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Glucose; Glucosides; Humans; Hyperglycemia; Hypoglycemic Agents; Indoles; Male; Mice; Mice, Inbred ICR; Rats; Rats, Sprague-Dawley; Sodium-Glucose Transporter 2 Inhibitors; Structure-Activity Relationship; Xylose	2011
Structure-activity relationship studies of 4-benzyl-1H-pyrazol-3-yl β-d-glucopyranoside derivatives as potent and selective sodium glucose co-transporter 1 (SGLT1) inhibitors with therapeutic activity on postprandial hyperglycemia. Bioorganic & medicinal chemistry, 2012, Nov-15, Volume: 20, Issue:22 Topics: Animals; Blood Glucose; Crystallography, X-Ray; Diabetes Mellitus, Experimental; Glucosides; Humans; Hyperglycemia; Hypoglycemic Agents; Molecular Conformation; Rats; Sodium-Glucose Transporter 1; Sodium-Glucose Transporter 2; Sodium-Glucose Transporter 2 Inhibitors; Structure-Activity Relationship	2012
Diabetic macular edema-like ocular lesions in male spontaneously diabetic torii fatty rats. Physiological research, 2018, 07-17, Volume: 67, Issue:3 Topics: Animals; Capillary Permeability; Diabetic Retinopathy; Disease Models, Animal; Hyperglycemia; Hypoglycemic Agents; Male; Phlorhizin; Pioglitazone; Rats; Retina; Thiazolidinediones; Vascular Endothelial Growth Factor A; Vitreous Body	2018
Phloridzin, an Apple Polyphenol, Exerted Unfavorable Effects on Bone and Muscle in an Experimental Model of Type 2 Diabetes in Rats. Nutrients, 2018, Nov-07, Volume: 10, Issue:11 Topics: Animals; Bone and Bones; Bone Density; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Diet, High-Fat; Female; Hyperglycemia; Hypoglycemic Agents; Malus; Muscle, Skeletal; Phloretin; Phlorhizin; Polyphenols; Rats; Rats, Wistar	2018
Decrease of FGF receptor (FGFR) and interstitial fibrosis in the kidney of streptozotocin-induced diabetic rats. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 2014, Volume: 46, Issue:1 Topics: 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Dogs; Fibroblast Growth Factor-23; Fibrosis; Glucuronidase; Hyperglycemia; Insulin; Kidney; Kidney Tubules; Klotho Proteins; Madin Darby Canine Kidney Cells; Male; Mice; Phlorhizin; Rats; Rats, Wistar; Receptors, Fibroblast Growth Factor; Superoxides	2014
mTORC1-independent reduction of retinal protein synthesis in type 1 diabetes. Diabetes, 2014, Volume: 63, Issue:9 Topics: alpha-Crystallin A Chain; Animals; beta-Crystallin B Chain; Blood Glucose; Carrier Proteins; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Eye Proteins; Hyperglycemia; Insulin; Intracellular Signaling Peptides and Proteins; Male; Mechanistic Target of Rapamycin Complex 2; Mice; Multiprotein Complexes; Phlorhizin; Phosphoproteins; Protein Biosynthesis; Proto-Oncogene Proteins c-akt; Rapamycin-Insensitive Companion of mTOR Protein; Rats; Receptor, Insulin; Regulatory-Associated Protein of mTOR; Retina; RNA, Ribosomal; TOR Serine-Threonine Kinases	2014
Contribution of hyperglycemia on diabetic complications in obese type 2 diabetic SDT fatty rats: effects of SGLT inhibitor phlorizin. Experimental animals, 2015, Volume: 64, Issue:2 Topics: Albuminuria; Animals; Blood Glucose; Diabetes Complications; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Diabetic Neuropathies; Diabetic Retinopathy; Disease Models, Animal; Female; Hyperglycemia; Kidney Tubules; Phlorhizin; Rats, Inbred Strains; Rats, Sprague-Dawley; Sodium-Glucose Transport Proteins	2015
Relationship between cerebral sodium-glucose transporter and hyperglycemia in cerebral ischemia. Neuroscience letters, 2015, Sep-14, Volume: 604 Topics: Animals; Cell Survival; Cells, Cultured; Cerebral Cortex; Hydrogen Peroxide; Hyperglycemia; Ischemic Attack, Transient; Male; Mice; Neurons; Phlorhizin; Sodium-Glucose Transport Proteins; Time Factors	2015
Preclinical metabolism and disposition of luseogliflozin, a novel antihyperglycemic agent. Xenobiotica; the fate of foreign compounds in biological systems, 2015, Volume: 45, Issue:12 Topics: Animals; Biotransformation; Blood Proteins; Dogs; Feces; Humans; Hyperglycemia; Hypoglycemic Agents; Intestinal Absorption; Kidney; Oxidation-Reduction; Phlorhizin; Rats; Rats, Sprague-Dawley; Sodium-Glucose Transporter 2; Sodium-Glucose Transporter 2 Inhibitors; Sorbitol; Tissue Distribution	2015
Phlorizin Supplementation Attenuates Obesity, Inflammation, and Hyperglycemia in Diet-Induced Obese Mice Fed a High-Fat Diet. Nutrients, 2016, Feb-16, Volume: 8, Issue:2 Topics: Adipose Tissue; Animals; Blood Glucose; Diet, High-Fat; Dietary Supplements; Hyperglycemia; Inflammation; Inflammation Mediators; Insulin Resistance; Lipid Metabolism; Liver; Male; Malus; Mice, Inbred C57BL; Mice, Obese; Obesity; Phlorhizin; Phytotherapy; Plant Extracts	2016
Real-time monitoring of glucose and phenols intestinal absorption through an integrated Caco-2TC7cells/biosensors telemetric device: Hypoglycemic effect of fruit phytochemicals. Biosensors & bioelectronics, 2017, 02-15, Volume: 88 Topics: Biosensing Techniques; Blueberry Plants; Cell Line; Equipment Design; Fruit and Vegetable Juices; Glucose; Humans; Hyperglycemia; Hypoglycemic Agents; Intestinal Absorption; Lythraceae; Phenols; Phloretin; Phlorhizin; Telemetry	2017
Role of hyperglycaemia in the pathogenesis of hypotension observed in type-1 diabetic rats. International journal of experimental pathology, 2008, Volume: 89, Issue:4 Topics: Animals; Arecoline; Baroreflex; Cell Line; Cholinergic Agonists; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Gene Expression; Glucose; Hyperglycemia; Hypotension; Insulin; Male; Phenylephrine; Phlorhizin; Rats; Rats, Wistar; Receptor, Muscarinic M2; RNA, Messenger	2008
Insulin stimulates Akt translocation to mitochondria: implications on dysregulation of mitochondrial oxidative phosphorylation in diabetic myocardium. Journal of molecular and cellular cardiology, 2009, Volume: 46, Issue:6 Topics: Animals; Biological Transport; Blotting, Western; Cells, Cultured; Diabetes Mellitus, Experimental; Electron Transport Complex IV; Electrophoresis, Polyacrylamide Gel; Heart; Hyperglycemia; Hypoglycemic Agents; Insulin; Mice; Mice, Inbred C57BL; Mitochondria, Heart; Myocardium; Oxidative Phosphorylation; Phlorhizin; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley	2009
Molecular mechanisms of tungstate-induced pancreatic plasticity: a transcriptomics approach. BMC genomics, 2009, Aug-28, Volume: 10 Topics: Animals; Cell Proliferation; Diabetes Mellitus, Experimental; Gene Expression Profiling; Hyperglycemia; Hypoglycemic Agents; Insulin-Secreting Cells; Male; Mitogen-Activated Protein Kinases; Oligonucleotide Array Sequence Analysis; Pancreas; Phlorhizin; Rats; Rats, Wistar; Streptozocin; Tungsten Compounds	2009
Activation of sodium-glucose cotransporter 1 ameliorates hyperglycemia by mediating incretin secretion in mice. American journal of physiology. Endocrinology and metabolism, 2009, Volume: 297, Issue:6 Topics: Animals; Blood Glucose; Diabetes Mellitus, Type 2; Gastric Inhibitory Polypeptide; Glucagon-Like Peptide 1; Glucose; Glucose Tolerance Test; Hyperglycemia; Intestine, Large; Male; Methylglucosides; Mice; Mice, Inbred C57BL; Phlorhizin; Random Allocation; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sodium-Glucose Transporter 1	2009
Kidney phosphatase in alimentary hyperglycemia and phlorhizin glycosuria; a dynamic mechanism for renal threshold for glucose. The American journal of the medical sciences, 1947, Volume: 213, Issue:3 Topics: Blood Glucose; Carbohydrate Metabolism; Carbohydrates; Glucose; Glycosuria; Humans; Hyperglycemia; Kidney; Phlorhizin; Phosphoric Monoester Hydrolases; Urine	1947
Kidney phosphatase in alimentary hyperglycemia and phlorhizin glycosuria; a dynamic mechanism for renal threshold for glucose. The Journal of biological chemistry, 1947, Volume: 168, Issue:1 Topics: Blood Glucose; Carbohydrate Metabolism; Carbohydrates; Glucose; Glycosuria; Hyperglycemia; Kidney; Phlorhizin; Phosphoric Monoester Hydrolases; Urine	1947
Hyperglycemia-induced O-GlcNAcylation and truncation of 4E-BP1 protein in liver of a mouse model of type 1 diabetes. The Journal of biological chemistry, 2011, Sep-30, Volume: 286, Issue:39 Topics: Acetylglucosamine; Adaptor Proteins, Signal Transducing; Animals; Blood Glucose; Carrier Proteins; Cell Cycle Proteins; Diabetes Mellitus, Type 1; Disease Models, Animal; Eukaryotic Initiation Factors; Glycosylation; Hyperglycemia; Liver; Mice; Mice, Transgenic; Phlorhizin; Phosphoproteins	2011
NADPH oxidase activation by hyperglycaemia in cardiomyocytes is independent of glucose metabolism but requires SGLT1. Cardiovascular research, 2011, Nov-01, Volume: 92, Issue:2 Topics: 6-Aminonicotinamide; Acetylglucosamine; Animals; Cell Death; Cells, Cultured; Dose-Response Relationship, Drug; Enzyme Activation; Glucose; Glycosylation; Hyperglycemia; Insulin Resistance; Male; Membrane Glycoproteins; Myocytes, Cardiac; NADPH Oxidase 2; NADPH Oxidases; Pentose Phosphate Pathway; Phlorhizin; Protein Processing, Post-Translational; Protein Transport; rac1 GTP-Binding Protein; Rats; Rats, Wistar; Reactive Oxygen Species; Sodium-Glucose Transporter 1	2011
Differential roles of hyperglycemia and hypoinsulinemia in diabetes induced retinal cell death: evidence for retinal insulin resistance. PloS one, 2011, Volume: 6, Issue:10 Topics: Animals; Cell Death; Diabetes Mellitus; Diabetic Retinopathy; Hyperglycemia; Insulin; Insulin Resistance; Phlorhizin; Rats; Retina; Signal Transduction	2011
Functional role of sodium glucose transporter in high glucose-mediated angiotensin type 1 receptor downregulation in human proximal tubule cells. American journal of physiology. Renal physiology, 2012, Volume: 303, Issue:5 Topics: Cells, Cultured; Down-Regulation; Glucose; Glucose Transport Proteins, Facilitative; Humans; Hyperglycemia; Kidney Tubules, Proximal; Phloretin; Phlorhizin; Receptor, Angiotensin, Type 1; Sodium-Glucose Transport Proteins	2012
Post-ischemic hyperglycemia exacerbates the development of cerebral ischemic neuronal damage through the cerebral sodium-glucose transporter. Brain research, 2012, Dec-13, Volume: 1489 Topics: Animals; Animals, Outbred Strains; Blood Glucose; Brain Ischemia; Disease Models, Animal; Dose-Response Relationship, Drug; Glucose; Glucose Intolerance; Hyperglycemia; Infarction, Middle Cerebral Artery; Injections, Intraperitoneal; Injections, Intraventricular; Male; Mice; Neurons; Phlorhizin; Sodium-Glucose Transporter 1; Stress, Physiological	2012
Selective SGLT2 inhibition by tofogliflozin reduces renal glucose reabsorption under hyperglycemic but not under hypo- or euglycemic conditions in rats. American journal of physiology. Endocrinology and metabolism, 2013, Feb-15, Volume: 304, Issue:4 Topics: Absorption; Animals; Benzhydryl Compounds; Blood Glucose; Creatinine; Dose-Response Relationship, Drug; Gluconeogenesis; Glucosides; Glycosuria; Hyperglycemia; Hypoglycemia; Hypoglycemic Agents; Kidney; Male; Phlorhizin; Rats; Rats, Wistar; Sodium Channel Blockers; Sodium-Glucose Transporter 1; Sodium-Glucose Transporter 2; Sodium-Glucose Transporter 2 Inhibitors	2013
Abnormal expression of pancreatic islet exocytotic soluble N-ethylmaleimide-sensitive factor attachment protein receptors in Goto-Kakizaki rats is partially restored by phlorizin treatment and accentuated by high glucose treatment. Endocrinology, 2002, Volume: 143, Issue:11 Topics: Animals; Carrier Proteins; Culture Techniques; Gene Expression; Glucose; Hyperglycemia; Immunoblotting; Insulin; Insulin Secretion; Islets of Langerhans; Male; Membrane Proteins; N-Ethylmaleimide-Sensitive Proteins; Phlorhizin; Rats; Rats, Wistar; Soluble N-Ethylmaleimide-Sensitive Factor Attachment Proteins; Vesicular Transport Proteins	2002
Evidence for rapid "metabolic switching" through lipoprotein lipase occupation of endothelial-binding sites. Journal of molecular and cellular cardiology, 2003, Volume: 35, Issue:9 Topics: Acute Disease; Animals; Binding Sites; Blood Glucose; Diabetes Mellitus, Experimental; Dichloroacetic Acid; Endothelial Cells; Endothelium, Vascular; Fatty Acids, Nonesterified; Gene Expression Regulation, Enzymologic; Hyperglycemia; Insulin; Lipolysis; Lipoprotein Lipase; Male; Malonyl Coenzyme A; Milk; Perfusion; Phlorhizin; Pyruvate Dehydrogenase Complex; Rats; Rats, Wistar; Streptozocin; Time Factors	2003
MECHANISM OF THE POTASSIUM MOBILIZING ACTION OF EPINEPHRINE AND GLUCAGON. The Journal of pharmacology and experimental therapeutics, 1963, Volume: 142 Topics: Carbon Dioxide; Cats; Dibenzylchlorethamine; Epinephrine; Ergotamine; Glucagon; Hyperglycemia; Hyperkalemia; Pharmacology; Phenoxybenzamine; Phentolamine; Phlorhizin; Potassium; Research; Sympatholytics	1963
Phloridzin improves hyperglycemia but not hepatic insulin resistance in a transgenic mouse model of type 2 diabetes. Diabetes, 2004, Volume: 53, Issue:11 Topics: Adipose Tissue; Animals; Blood Glucose; Body Composition; Diabetes Mellitus, Type 2; Disease Models, Animal; Energy Intake; Hyperglycemia; Insulin Resistance; Liver; Male; Mice; Mice, Transgenic; Phlorhizin	2004
Prevailing hyperglycemia is critical in the regulation of glucose metabolism during exercise in poorly controlled alloxan-diabetic dogs. Journal of applied physiology (Bethesda, Md. : 1985), 2005, Volume: 98, Issue:3 Topics: Alloxan; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Dogs; Drug Combinations; Exercise Test; Fatty Acids, Nonesterified; Glucose; Homeostasis; Hyperglycemia; Men; Muscle, Skeletal; Phlorhizin; Physical Exertion	2005
Nonobese, insulin-deficient Ins2Akita mice develop type 2 diabetes phenotypes including insulin resistance and cardiac remodeling. American journal of physiology. Endocrinology and metabolism, 2007, Volume: 293, Issue:6 Topics: Adipose Tissue; Animals; Blood Glucose; Diabetes Mellitus, Type 2; Energy Metabolism; Fatty Acids; Glucose; Glucose Clamp Technique; Glucose Transporter Type 4; Hyperglycemia; Hypertrophy, Left Ventricular; Insulin; Insulin Resistance; Liver; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Muscle, Skeletal; Oxygen Consumption; Phlorhizin; Protein Kinase C-epsilon; Triglycerides; Ventricular Remodeling	2007
Na(+) -glucose transporter-2 messenger ribonucleic acid expression in kidney of diabetic rats correlates with glycemic levels: involvement of hepatocyte nuclear factor-1alpha expression and activity. Endocrinology, 2008, Volume: 149, Issue:2 Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Electrophoretic Mobility Shift Assay; Hepatocyte Nuclear Factor 1-alpha; Hyperglycemia; Hypoglycemic Agents; Immunoprecipitation; Insulin; Kidney; Male; Phlorhizin; Rats; Rats, Wistar; RNA, Messenger; Sodium-Glucose Transporter 2	2008
Intestinal sugar transport in experimental diabetes. Diabetes, 1981, Volume: 30, Issue:7 Topics: 3-O-Methylglucose; Animals; Blood Glucose; Cycloheximide; Diabetes Mellitus, Experimental; Galactose; Glucose; Hyperglycemia; Insulin; Intestinal Absorption; Intestine, Small; Male; Methylglucosides; Methylglycosides; Phloretin; Phlorhizin; Rats; Streptozocin	1981
Effect of hyperglycaemia on sugar transport in the isolated mucosa of guinea-pig small intestine. The Journal of physiology, 1984, Volume: 355 Topics: 3-O-Methylglucose; Animals; Blood Glucose; Glucose; Guinea Pigs; Hyperglycemia; In Vitro Techniques; Intestinal Absorption; Intestinal Mucosa; Jejunum; Methylglucosides; Phlorhizin; Polyethylene Glycols; Time Factors	1984
Opposite effects of hyperglycemia and insulin deficiency on liver glycogen synthase phosphatase activity in the diabetic rat. Diabetes, 1993, Volume: 42, Issue:2 Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Glucagon; Glucokinase; Glucose; Glucose-6-Phosphatase; Glycogen-Synthase-D Phosphatase; Hexosephosphates; Hyperglycemia; Insulin; Liver; Male; Phlorhizin; Rats; Rats, Sprague-Dawley	1993
Hyperglycemia promotes elevated generation of TXA2 in isolated rat uteri. Prostaglandins, 1995, Volume: 50, Issue:1 Topics: Animals; Arachidonic Acid; Blood Glucose; Dinoprost; Dinoprostone; Female; Glucose; Hyperglycemia; In Vitro Techniques; Ovariectomy; Phlorhizin; Rats; Thromboxane A2; Thromboxane B2; Uterus	1995
Glucose regulates in vivo glucose-6-phosphatase gene expression in the liver of diabetic rats. The Journal of biological chemistry, 1996, Apr-26, Volume: 271, Issue:17 Topics: Animals; Diabetes Mellitus, Experimental; Energy Metabolism; Gene Expression Regulation, Enzymologic; Glucose; Glucose-6-Phosphatase; Hyperglycemia; Insulin; Liver; Male; Phlorhizin; Rats; Rats, Sprague-Dawley; RNA, Messenger	1996
Poor capacity for proliferation of pancreatic beta-cells in Otsuka-Long-Evans-Tokushima Fatty rat: a model of spontaneous NIDDM. Diabetes, 1996, Volume: 45, Issue:7 Topics: Animals; Blood Glucose; Body Weight; Cell Division; Diabetes Mellitus; Diabetes Mellitus, Type 2; Female; Humans; Hyperglycemia; Islets of Langerhans; Male; Niacinamide; Obesity; Pancreatectomy; Phlorhizin; Rats; Rats, Mutant Strains	1996
Mechanisms of postabsorptive hyperglycemia in streptozotocin diabetic rats. The American journal of physiology, 1996, Volume: 270, Issue:5 Pt 1 Topics: Absorption; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Glucagon; Glucose; Glycogen; Glycosuria; Hyperglycemia; Insulin; Liver; Male; Phlorhizin; Rats; Rats, Wistar; Time Factors	1996
Relative contribution of glycogenolysis and gluconeogenesis to hepatic glucose production in control and diabetic rats. A re-examination in the presence of euglycaemia. Diabetologia, 1998, Volume: 41, Issue:3 Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Disease Models, Animal; Fatty Acids, Nonesterified; Gluconeogenesis; Glucose; Glucose Clamp Technique; Glucose-6-Phosphate; Hyperglycemia; Hyperinsulinism; Hypoglycemic Agents; Insulin; Liver; Liver Glycogen; Male; Phlorhizin; Rats; Rats, Sprague-Dawley; Reference Values; Sodium Chloride	1998
Influence of age, hyperglycemia, leptin, and NPY on islet blood flow in obese-hyperglycemic mice. The American journal of physiology, 1998, Volume: 275, Issue:4 Topics: Aging; Animals; Arginine; Blood Glucose; Body Weight; Hyperglycemia; Hyperinsulinism; Insulin; Insulin Secretion; Islets of Langerhans; Leptin; Mice; Mice, Inbred C57BL; Mice, Obese; Neuropeptide Y; Obesity; Organ Size; Pancreas; Perfusion; Phlorhizin; Proteins; Receptors, Leptin; Receptors, Neuropeptide Y; Regional Blood Flow	1998
Effect of partial pancreatectomy on beta-cell mass in the remnant pancreas of Wistar fatty rats. The journal of medical investigation : JMI, 1998, Volume: 45, Issue:1-4 Topics: Animals; Blood Glucose; Cell Division; Diabetes Mellitus; Diabetes Mellitus, Type 2; Disease Models, Animal; Genotype; Hyperglycemia; Insulin; Insulin Resistance; Islets of Langerhans; Male; Niacinamide; Obesity; Pancreatectomy; Phenotype; Phlorhizin; Rats; Rats, Inbred WKY; Rats, Mutant Strains; Rats, Wistar; Rats, Zucker	1998
Increased intestinal glucose absorption and postprandial hyperglycaemia at the early step of glucose intolerance in Otsuka Long-Evans Tokushima Fatty rats. Diabetologia, 1998, Volume: 41, Issue:12 Topics: Animals; Diabetes Mellitus; Diabetes Mellitus, Type 2; Food; Gene Expression; Glucose; Glucose Intolerance; Glucose Tolerance Test; Hyperglycemia; Insulin Resistance; Intestinal Absorption; Intestines; Male; Monosaccharide Transport Proteins; Obesity; Phlorhizin; Rats; Rats, Long-Evans; Xylose	1998
Chronic hyperglycemia triggers loss of pancreatic beta cell differentiation in an animal model of diabetes. The Journal of biological chemistry, 1999, May-14, Volume: 274, Issue:20 Topics: Animals; Blood Glucose; Body Weight; Cell Differentiation; Chronic Disease; Diabetes Mellitus, Experimental; Disease Models, Animal; DNA Primers; Fatty Acids, Nonesterified; Humans; Hyperglycemia; Insulin; Islets of Langerhans; Male; Pancreatic Hormones; Phlorhizin; Rats; Rats, Sprague-Dawley; RNA, Messenger	1999
Hyperglycemia contributes to impaired insulin response in GK rat islets. Diabetes, 2001, Volume: 50 Suppl 1 Topics: Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Glucose; Glucose-6-Phosphatase; Hyperglycemia; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Male; Oxidation-Reduction; Phlorhizin; Rats; Rats, Wistar	2001
beta-cell adaptation to hyperglycemia. Diabetes, 2001, Volume: 50 Suppl 1 Topics: Acyl-CoA Oxidase; Adaptation, Physiological; Animals; Carnitine O-Palmitoyltransferase; Gene Expression Regulation; Hyperglycemia; Islets of Langerhans; Oxidoreductases; Pancreatectomy; Phlorhizin; Rats; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Transcription Factors	2001
Glucose toxicity and the development of diabetes in mice with muscle-specific inactivation of GLUT4. The Journal of clinical investigation, 2001, Volume: 108, Issue:1 Topics: Adipose Tissue; Age of Onset; Animals; Depression, Chemical; Diabetes Mellitus, Type 2; Disease Models, Animal; Glucose; Glucose Transporter Type 4; Hyperglycemia; Insulin; Insulin Infusion Systems; Insulin Resistance; Kidney Tubules; Liver; Male; Mice; Mice, Knockout; Monosaccharide Transport Proteins; Muscle Proteins; Muscle, Skeletal; Phlorhizin; Prediabetic State; Protein Transport	2001
Regulation of glucose transporter messenger RNA levels in rat adipose tissue by insulin. Molecular endocrinology (Baltimore, Md.), 1990, Volume: 4, Issue:4 Topics: Adipose Tissue; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Epididymis; Fasting; Gene Expression Regulation; Hyperglycemia; Insulin; Male; Monosaccharide Transport Proteins; Phlorhizin; Rats; Rats, Inbred Strains; RNA, Messenger; Stimulation, Chemical; Streptozocin	1990
Correction of chronic hyperglycemia with vanadate, but not with phlorizin, normalizes in vivo glycogen repletion and in vitro glycogen synthase activity in diabetic skeletal muscle. The Journal of clinical investigation, 1989, Volume: 84, Issue:3 Topics: Animals; Chronic Disease; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Glucose Clamp Technique; Glycogen; Glycogen Synthase; Hyperglycemia; Insulin; Liver; Male; Muscles; Phlorhizin; Rats; Rats, Inbred Strains; Vanadates	1989
Effect of chronic hyperglycemia on in vivo insulin secretion in partially pancreatectomized rats. The Journal of clinical investigation, 1987, Volume: 80, Issue:4 Topics: Animals; Arginine; Blood Glucose; Body Weight; Chronic Disease; Diabetes Mellitus, Experimental; Glycosuria; Hyperglycemia; Insulin; Insulin Secretion; Islets of Langerhans; Male; Pancreas; Pancreatectomy; Phlorhizin; Rats; Rats, Inbred Strains	1987
Antecedent chronic hyperglycaemia blocks phlorizin-induced insulin resistance in the dog. Diabetologia, 1988, Volume: 31, Issue:4 Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Dogs; Glucagon; Glycosuria; Hyperglycemia; Insulin Resistance; Kidney; Male; Phlorhizin	1988
Correction of hyperglycemia with phlorizin normalizes tissue sensitivity to insulin in diabetic rats. The Journal of clinical investigation, 1987, Volume: 79, Issue:5 Topics: Animals; Diabetes Mellitus, Experimental; Glycosuria; Hyperglycemia; Hyperinsulinism; Insulin Resistance; Male; Phlorhizin; Rats; Rats, Inbred Strains	1987
Role of glucose reabsorption from bile on hyperglycaemia-induced cholestasis in the rabbit. Journal of hepatology, 1986, Volume: 3, Issue:1 Topics: Animals; Bile; Biological Transport; Blood Glucose; Cholestasis; Glucose; Hyperglycemia; Male; Phlorhizin; Rabbits	1986
Correction of hyperglycemia with phloridzin restores the glucagon response to glucose in insulin-deficient dogs: implications for human diabetes. Proceedings of the National Academy of Sciences of the United States of America, 1985, Volume: 82, Issue:5 Topics: Animals; Diabetes Mellitus, Experimental; Dogs; Glucagon; Glucose; Hyperglycemia; Islets of Langerhans; Phlorhizin	1985
Fourth ventricular phlorizin dissociates feeding from hyperglycemia in rats. Brain research, 1985, Aug-26, Volume: 341, Issue:2 Topics: Animals; Brain Stem; Feeding Behavior; Glucose; Hyperglycemia; Injections, Intraventricular; Insulin; Male; Phlorhizin; Rats; Rats, Inbred Strains	1985
Effects of phlorizin on metabolism and function of pancreatic -cell. Metabolism: clinical and experimental, 1972, Volume: 21, Issue:1 Topics: Animals; Autoradiography; Binding Sites; Biological Transport; Carbon Isotopes; Fructosephosphates; Glucose; Glucosephosphates; Hyperglycemia; Insulin; Insulin Secretion; Islets of Langerhans; Mice; Mice, Inbred Strains; Obesity; Oxidation-Reduction; Phlorhizin; Tritium	1972
The pancreatic -cell recognition of insulin secretagogues. I. Transport of mannoheptulose and the dynamics of insulin release. Molecular pharmacology, 1972, Volume: 8, Issue:1 Topics: Animals; Biological Transport; Carbon Isotopes; Cells; Ethers; Female; Glucose; Heptoses; Hyperglycemia; Insulin; Insulin Secretion; Iodine Isotopes; Islets of Langerhans; Kinetics; Male; Mice; Obesity; Phlorhizin; Radioimmunoassay; Receptors, Drug; Sucrose; Tritium	1972
The pancreatic -cell recognition of insulin secretagogues. V. Binding and stimulatory action of phlorizin. Molecular pharmacology, 1972, Volume: 8, Issue:6 Topics: Animals; Antimycin A; Arginine; Carbon Isotopes; Chloromercuribenzoates; Chlorpromazine; Diabetes Mellitus; Dose-Response Relationship, Drug; Glucose; Heptoses; Hyperglycemia; Insulin; Insulin Secretion; Iodine Isotopes; Islets of Langerhans; Ketones; Mice; Obesity; Organ Size; Phloretin; Phlorhizin; Sucrose; Theophylline; Time Factors; Tritium	1972
Transport of 3-O-methyl-D-glucose into mammalian pancreatic -cells. Pflugers Archiv : European journal of physiology, 1973, Volume: 340, Issue:1 Topics: Animals; Biological Transport, Active; Carbon Isotopes; Cell Membrane; Glucosamine; Glucose; Heptoses; Hyperglycemia; Islets of Langerhans; Mannitol; Mice; Obesity; Phloretin; Phlorhizin; Sucrose	1973
Calcium uptake by pancreatic -cells as measured with the aid of 45 Ca and mannitol- 3 H. The American journal of physiology, 1971, Volume: 221, Issue:6 Topics: Animals; Biological Transport, Active; Calcium; Calcium Isotopes; Diazoxide; Dinitrophenols; Female; Glucose; Heptoses; Hyperglycemia; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Male; Mannitol; Mice; Obesity; Osmolar Concentration; Phlorhizin; Potassium; Sodium; Subcellular Fractions; Tritium	1971
Evidence for mediated transport of glucose in mammalian pancreatic -cells. Biochimica et biophysica acta, 1971, Jul-06, Volume: 241, Issue:1 Topics: Animals; Biological Transport; Carbon Isotopes; Cell Membrane Permeability; Extracellular Space; Fasting; Glucose; Heptoses; Hyperglycemia; Islets of Langerhans; Ketones; Kinetics; Mice; Obesity; Phlorhizin; Stereoisomerism; Sucrose; Tritium	1971
Effects of epinephrine, hydrocortisone, and thyroxine on phlorizin-induced ketosis in fasted, nonpregnant ewes. American journal of veterinary research, 1966, Volume: 27, Issue:119 Topics: Acidosis; Animals; Epinephrine; Fasting; Fatty Acids; Fatty Acids, Nonesterified; Hydrocortisone; Hyperglycemia; Lipids; Phlorhizin; Sheep; Thyroxine	1966