phlorhizin has been researched along with Disease Models, Animal in 35 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (11.43) | 18.7374 |
| 1990's | 6 (17.14) | 18.2507 |
| 2000's | 5 (14.29) | 29.6817 |
| 2010's | 14 (40.00) | 24.3611 |
| 2020's | 6 (17.14) | 2.80 |
| Authors | Studies |
|---|---|
| Demarest, K; Du, F; Gaul, MD; Kuo, GH; Liang, Y; Xu, G; Xu, JZ | 1 |
| Chang, CK; Chiu, PF; Hsu, LC; Juang, YP; Lai, YH; Liang, PH; Lin, TS; Yang, HY; Yu, LC | 1 |
| Hirose, M; Ishida, N; Saito, M; Sanbe, A; Sato, S; Taira, E; Tezuka, Y | 1 |
| Chen, L; Cheng, J; Fu, S; Hu, G; Huang, Y; Li, Y; Liu, D; Yang, Z | 1 |
| Aguiar, EMG; Caixeta, DC; Cardoso-Sousa, L; Costa, DPD; Cunha, TM; Espindola, FS; Faria, PR; Goulart, LR; Jardim, AC; Oliveira, TL; Sabino-Silva, R; Silva, TL; Vieira, AA; Vilela, DD | 1 |
| Kamdi, SP; Nakhate, KT; Raval, A | 1 |
| Jaggi, AS; Kumar, A; Rani, R; Singh, N | 1 |
| Accili, D; Ishida, E; Kim-Muller, JY | 1 |
| Antika, LD; Choi, YJ; Kang, MK; Kang, YH; Kim, DY; Kim, YH; Lee, EJ; Oh, H; Park, SH | 1 |
| Kakehashi, A; Kemmochi, Y; Maekawa, T; Motohashi, Y; Ohta, T; Sasase, T; Tadaki, H; Tanaka, Y; Yamada, T | 1 |
| Rieg, T; Vallon, V | 1 |
| Ito, K; Kashiwagi, Y; Kimura, H; Nagoshi, T; Oi, Y; Tanaka, TD; Tanaka, Y; Yoshii, A; Yoshimura, M; Yoshino, T | 1 |
| Devuyst, O; Kapoor, S; Koepsell, H; Liu, Y; Mei, C; Mohebbi, N; Rodriguez, D; Segerer, S; Serra, AL; Spichtig, D; Wang, X; Wüthrich, RP; Zhang, S | 1 |
| Harada, S; Nishioka, H; Tokuyama, S; Yamazaki, Y | 1 |
| Araki, E; Goto, R; Igata, M; Kawasaki, S; Kawashima, J; Kitano, S; Kondo, T; Matsumura, T; Matsuyama, R; Miyagawa, K; Motoshima, H; Ono, K | 1 |
| Kakimoto, K; Katsuda, Y; Kemmochi, Y; Kume, S; Mera, Y; Motohashi, Y; Ohta, T; Sasase, T; Tadaki, H; Toyoda, K | 1 |
| Despa, F; Despa, S; Lambert, R; Margulies, KB; Peng, X; Srodulski, S | 1 |
| Harada, S; Tokuyama, S; Wada, T; Yamazaki, Y; Yoshida, S | 1 |
| Akimoto, Y; Kobori, M; Masumoto, S; Oike, H | 1 |
| Bronson, SK; Dennis, MD; Jefferson, LS; Kimball, SR; Schrufer, TL | 1 |
| Harada, S; Tokuyama, S; Yamazaki, Y | 1 |
| Chang, CC; Chen, CL; Chen, HC; Hsieh, MC; Shin, SJ; Wu, CH | 1 |
| Gavrilova, O; Jou, W; Kim, H; LeRoith, D; Setser, J; Sun, H; Yakar, S; Zhang, Y; Zhao, H | 1 |
| Coxam, V; Davicco, MJ; Horcajada, MN; Kati-Coulibaly, S; Lebecque, P; Mathey, J; Obled, C; Puel, C; Quintin, A | 1 |
| Beitz, DC; Lyle, RR; Mills, SE; Young, JW | 1 |
| Bertram, B; Hilgard, P; Nowrousian, MR; Pohl, J; Stüben, J; Wiessler, M | 1 |
| Nolan, CJ; Proietto, J | 1 |
| Buongiorno, A; Giaccari, A; Maroccia, E; Morviducci, L; Pastore, L; Sbraccia, P; Tamburrano, G; Zorretta, D | 1 |
| Beaulieu, AD; Clark, JH; Drackley, JK; Ottemann-Abbamonte, CJ; Overton, TR | 1 |
| Kuwajima, M; Murakami, T; Ogino, T; Shima, K; Zhu, M | 1 |
| Bonner-Weir, S; Hasenkamp, W; Ilkova, H; Jonas, JC; Laybutt, R; Patanè, G; Sharma, A; Weir, GC | 1 |
| Dong, J; Fillmore, JJ; Kahn, BB; Kahn, CR; Kim, JK; Kotani, K; Peroni, OD; Perret, P; Shulman, GI; Zisman, A; Zong, H | 1 |
| Zander, HD | 1 |
| Giesecke, D; Günzel, R | 1 |
| Hartmann, N; Hübner, G; Voss, C | 1 |
2 review(s) available for phlorhizin and Disease Models, Animal
| Article | Year |
|---|---|
Development of SGLT1 and SGLT2 inhibitors.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diabetic Ketoacidosis; Disease Models, Animal; Drug Design; Glucose; Humans; Intestinal Mucosa; Kidney; Mice; Mutation; Phlorhizin; Sodium-Glucose Transporter 1; Sodium-Glucose Transporter 2; Sodium-Glucose Transporter 2 Inhibitors | 2018 |
[Experimental induction of obesity in animals].
Topics: Adrenocorticotropic Hormone; Animals; Aurothioglucose; Cats; Cyproheptadine; Diet; Dietary Fats; Disease Models, Animal; Dogs; Hypothalamus; Insulin; Mice; Mustard Compounds; Obesity; Phlorhizin; Quinolines; Rabbits; Rats | 1972 |
33 other study(ies) available for phlorhizin and Disease Models, Animal
| Article | Year |
|---|---|
5,5-Difluoro- and 5-Fluoro-5-methyl-hexose-based C-Glucosides as potent and orally bioavailable SGLT1 and SGLT2 dual inhibitors.
Topics: Animals; Blood Glucose; Diabetes Mellitus; Disease Models, Animal; Drug Design; Glucose Tolerance Test; Glucosides; Half-Life; Halogenation; Humans; Hypoglycemic Agents; Inhibitory Concentration 50; Mice; Mice, Inbred C57BL; Microsomes; Rats; Rats, Sprague-Dawley; Sodium-Glucose Transporter 1; Sodium-Glucose Transporter 2; Structure-Activity Relationship | 2020 |
Targeting Colorectal Cancer with Conjugates of a Glucose Transporter Inhibitor and 5-Fluorouracil.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Survival; Colorectal Neoplasms; Disease Models, Animal; Drug Stability; Enzyme Inhibitors; Fluorouracil; Glucose Transport Proteins, Facilitative; Half-Life; Humans; Mice; Mice, Inbred BALB C; Phloretin; Phlorhizin; Structure-Activity Relationship; Tissue Distribution | 2021 |
Mizagliflozin, a selective SGLT1 inhibitor, improves vascular cognitive impairment in a mouse model of small vessel disease.
Topics: Animals; Carotid Artery, Common; Cerebral Small Vessel Diseases; Cerebrovascular Circulation; Cognition; Cognitive Dysfunction; Cytokines; Disease Models, Animal; Glucosides; Hippocampus; Inflammation; Mice; Morris Water Maze Test; Neurons; Phlorhizin; Pyrazoles; Sodium-Glucose Transporter 1 | 2021 |
Phlorizin Mitigates Dextran Sulfate Sodium-Induced Colitis in Mice by Modulating Gut Microbiota and Inhibiting Ferroptosis.
Topics: Animals; Colitis; Colitis, Ulcerative; Colon; Dextran Sulfate; Disease Models, Animal; Ferroptosis; Gastrointestinal Microbiome; Mice; Mice, Inbred C57BL; Phlorhizin | 2023 |
Effects of salbutamol and phlorizin on acute pulmonary inflammation and disease severity in experimental sepsis.
Topics: Acute Lung Injury; Albuterol; Alveolar Epithelial Cells; Animals; Bronchoalveolar Lavage Fluid; Cytokines; Cytoplasm; Disease Models, Animal; Lung; Male; Oxidative Stress; Phlorhizin; Pneumonia; Rats; Rats, Wistar; Sepsis; Severity of Illness Index; Sodium-Glucose Transporter 1 | 2019 |
Phloridzin attenuates lipopolysaccharide-induced cognitive impairment via antioxidant, anti-inflammatory and neuromodulatory activities.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Cognitive Dysfunction; Disease Models, Animal; Glutathione; Hippocampus; Lipopolysaccharides; Male; Maze Learning; Memory; Memory Disorders; Mice; Neuroinflammatory Diseases; Neuroprotective Agents; Neurotransmitter Agents; Oxidative Stress; Phlorhizin; Superoxide Dismutase; Tumor Necrosis Factor-alpha | 2021 |
Pharmacological investigations on efficacy of Phlorizin a sodium-glucose co-transporter (SGLT) inhibitor in mouse model of intracerebroventricular streptozotocin induced dementia of AD type.
Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Brain; Disease Models, Animal; Glucose; Maze Learning; Mice; Oxidative Stress; Phlorhizin; Sodium; Streptozocin; Symporters | 2021 |
Pair Feeding, but Not Insulin, Phloridzin, or Rosiglitazone Treatment, Curtails Markers of β-Cell Dedifferentiation in
Topics: Animals; Biomarkers; Blood Glucose; Cell Dedifferentiation; Diabetes Mellitus, Type 2; Disease Models, Animal; Eating; Humans; Hypoglycemic Agents; Insulin; Insulin-Secreting Cells; Mice; Phlorhizin; Rosiglitazone; Thiazolidinediones | 2017 |
Dietary phlorizin enhances osteoblastogenic bone formation through enhancing β-catenin activity via GSK-3β inhibition in a model of senile osteoporosis.
Topics: Animals; beta Catenin; Biomarkers; Bone and Bones; Bone Density; Bone Density Conservation Agents; Cell Line; Cell Survival; Chalcones; Dietary Supplements; Disease Models, Animal; Gene Expression Regulation, Developmental; Glycogen Synthase Kinase 3 beta; Male; Mice; Osteoblasts; Osteogenesis; Osteoporosis; Phloretin; Phlorhizin; Specific Pathogen-Free Organisms; Wnt Signaling Pathway | 2017 |
Diabetic macular edema-like ocular lesions in male spontaneously diabetic torii fatty rats.
Topics: Animals; Capillary Permeability; Diabetic Retinopathy; Disease Models, Animal; Hyperglycemia; Hypoglycemic Agents; Male; Phlorhizin; Pioglitazone; Rats; Retina; Thiazolidinediones; Vascular Endothelial Growth Factor A; Vitreous Body | 2018 |
Cardiac ischemia-reperfusion injury under insulin-resistant conditions: SGLT1 but not SGLT2 plays a compensatory protective role in diet-induced obesity.
Topics: Animals; Benzhydryl Compounds; Blood Glucose; Canagliflozin; Diet, High-Fat; Disease Models, Animal; Glucose Transporter Type 4; Glucosides; Insulin Resistance; Isolated Heart Preparation; Male; Mice, Inbred C57BL; Myocardial Reperfusion Injury; Myocytes, Cardiac; Obesity; Phlorhizin; Signal Transduction; Sodium-Glucose Transporter 1; Sodium-Glucose Transporter 2; Sodium-Glucose Transporter 2 Inhibitors; Thiophenes | 2019 |
Targeting of sodium-glucose cotransporters with phlorizin inhibits polycystic kidney disease progression in Han:SPRD rats.
Topics: Albuminuria; Animals; Cell Proliferation; Cells, Cultured; Disease Models, Animal; Disease Progression; Diuresis; Dose-Response Relationship, Drug; Glycosuria; Heterozygote; Ki-67 Antigen; Kidney; Male; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Molecular Targeted Therapy; Phlorhizin; Polycystic Kidney Diseases; Rats; Sodium-Glucose Transport Proteins; Time Factors; Urological Agents | 2013 |
Neuroprotective effect through the cerebral sodium-glucose transporter on the development of ischemic damage in global ischemia.
Topics: Animals; Brain Ischemia; Disease Models, Animal; Male; Mice; Neuroprotective Agents; Phlorhizin; Sodium-Glucose Transport Proteins | 2013 |
Effects of combination therapy with vildagliptin and valsartan in a mouse model of type 2 diabetes.
Topics: Adamantane; Adiponectin; Angiotensin II Type 1 Receptor Blockers; Animals; Blood Glucose; Cytokines; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Dipeptidyl-Peptidase IV Inhibitors; Disease Models, Animal; Drug Therapy, Combination; Fatty Liver; Homeodomain Proteins; Inflammation; Insulin; Insulin Resistance; Insulin Secretion; Insulin-Secreting Cells; Mice; Mice, Inbred C57BL; Nitriles; Phlorhizin; Pyrrolidines; Tetrazoles; Trans-Activators; Valine; Valsartan; Vildagliptin | 2013 |
Contribution of hyperglycemia on diabetic complications in obese type 2 diabetic SDT fatty rats: effects of SGLT inhibitor phlorizin.
Topics: Albuminuria; Animals; Blood Glucose; Diabetes Complications; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Diabetic Neuropathies; Diabetic Retinopathy; Disease Models, Animal; Female; Hyperglycemia; Kidney Tubules; Phlorhizin; Rats, Inbred Strains; Rats, Sprague-Dawley; Sodium-Glucose Transport Proteins | 2015 |
Intracellular Na+ Concentration ([Na+]i) Is Elevated in Diabetic Hearts Due to Enhanced Na+-Glucose Cotransport.
Topics: Aged; Animals; Diabetes Mellitus, Type 2; Diabetic Cardiomyopathies; Disease Models, Animal; Female; Heart Failure; Humans; Male; Middle Aged; Myocardium; Myocytes, Cardiac; Phlorhizin; Rats, Sprague-Dawley; Sodium; Sodium-Glucose Transporter 1; Time Factors; Up-Regulation | 2015 |
Sodium transport through the cerebral sodium-glucose transporter exacerbates neuron damage during cerebral ischaemia.
Topics: Animals; Blood Glucose; Brain Ischemia; Cell Death; Cell Survival; Cerebral Cortex; Disease Models, Animal; Dose-Response Relationship, Drug; Glucose; Hydrogen Peroxide; Infarction, Middle Cerebral Artery; Infusions, Intraventricular; Methylglucosides; Mice; Neurons; Phlorhizin; Primary Cell Culture; Sodium; Sodium-Glucose Transporter 1 | 2016 |
Dietary phloridzin reduces blood glucose levels and reverses Sglt1 expression in the small intestine in streptozotocin-induced diabetic mice.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Blood Glucose; Cytochrome P450 Family 2; Diabetes Mellitus, Experimental; Disease Models, Animal; Gene Expression; Humans; Intestine, Small; Male; Mice; Mice, Inbred BALB C; Phlorhizin; Sodium-Glucose Transporter 1; Steroid Hydroxylases; Streptozocin | 2009 |
Hyperglycemia-induced O-GlcNAcylation and truncation of 4E-BP1 protein in liver of a mouse model of type 1 diabetes.
Topics: Acetylglucosamine; Adaptor Proteins, Signal Transducing; Animals; Blood Glucose; Carrier Proteins; Cell Cycle Proteins; Diabetes Mellitus, Type 1; Disease Models, Animal; Eukaryotic Initiation Factors; Glycosylation; Hyperglycemia; Liver; Mice; Mice, Transgenic; Phlorhizin; Phosphoproteins | 2011 |
Post-ischemic hyperglycemia exacerbates the development of cerebral ischemic neuronal damage through the cerebral sodium-glucose transporter.
Topics: Animals; Animals, Outbred Strains; Blood Glucose; Brain Ischemia; Disease Models, Animal; Dose-Response Relationship, Drug; Glucose; Glucose Intolerance; Hyperglycemia; Infarction, Middle Cerebral Artery; Injections, Intraperitoneal; Injections, Intraventricular; Male; Mice; Neurons; Phlorhizin; Sodium-Glucose Transporter 1; Stress, Physiological | 2012 |
High blood glucose and osmolality, but not high urinary glucose and osmolality, affect neuronal nitric oxide synthase expression in diabetic rat kidney.
Topics: Actins; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Disease Models, Animal; Kidney; Male; Nerve Tissue Proteins; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Osmolar Concentration; Phlorhizin; Rats; Rats, Wistar; RNA, Messenger | 2003 |
Phloridzin improves hyperglycemia but not hepatic insulin resistance in a transgenic mouse model of type 2 diabetes.
Topics: Adipose Tissue; Animals; Blood Glucose; Body Composition; Diabetes Mellitus, Type 2; Disease Models, Animal; Energy Intake; Hyperglycemia; Insulin Resistance; Liver; Male; Mice; Mice, Transgenic; Phlorhizin | 2004 |
Prevention of bone loss by phloridzin, an apple polyphenol, in ovariectomized rats under inflammation conditions.
Topics: Animals; Body Weight; Bone Density; Bone Diseases, Metabolic; Bone Resorption; Disease Models, Animal; Female; Femur; Inflammation; Malus; Organ Size; Osteocalcin; Ovariectomy; Phlorhizin; Plant Extracts; Rats; Rats, Wistar; Stress, Mechanical; Weight-Bearing | 2005 |
In vitro hepatic gluconeogenesis during experimental ketosis produced in steers by 1,3-butanediol and phlorizin.
Topics: Acidosis; Animals; Butylene Glycols; Cattle; Cattle Diseases; Disease Models, Animal; Gluconeogenesis; In Vitro Techniques; Ketosis; Liver; Liver Glycogen; Male; Phlorhizin; Triglycerides | 1984 |
D-19575--a sugar-linked isophosphoramide mustard derivative exploiting transmembrane glucose transport.
Topics: Absorption; Administration, Oral; Animals; Antineoplastic Agents; Bone Marrow; Bone Marrow Cells; Cells, Cultured; Colony-Forming Units Assay; Disease Models, Animal; Drug Evaluation; Drug Tolerance; Female; Glucose; Ifosfamide; Kidney; Leukocytes; Mice; Monosaccharide Transport Proteins; Neoplasm Transplantation; Neoplasms, Experimental; Phlorhizin; Phosphoramide Mustards; Rats; Rats, Sprague-Dawley; Specific Pathogen-Free Organisms; Spleen; Tumor Cells, Cultured | 1995 |
The feto-placental glucose steal phenomenon is a major cause of maternal metabolic adaptation during late pregnancy in the rat.
Topics: Adaptation, Physiological; Animals; Disease Models, Animal; Female; Fetus; Glucose; Maternal-Fetal Exchange; Phlorhizin; Placenta; Pregnancy; Pregnancy in Diabetics; Rats; Rats, Sprague-Dawley | 1994 |
Relative contribution of glycogenolysis and gluconeogenesis to hepatic glucose production in control and diabetic rats. A re-examination in the presence of euglycaemia.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Disease Models, Animal; Fatty Acids, Nonesterified; Gluconeogenesis; Glucose; Glucose Clamp Technique; Glucose-6-Phosphate; Hyperglycemia; Hyperinsulinism; Hypoglycemic Agents; Insulin; Liver; Liver Glycogen; Male; Phlorhizin; Rats; Rats, Sprague-Dawley; Reference Values; Sodium Chloride | 1998 |
Metabolic adaptation to experimentally increased glucose demand in ruminants.
Topics: 3-Hydroxybutyric Acid; Animals; Blood Glucose; Blood Urea Nitrogen; Disease Models, Animal; Fatty Acids, Nonesterified; Glucagon; Gluconeogenesis; Glucose; Glycosuria; Hydrocortisone; Insulin; Liver; Male; Phlorhizin; Sheep; Sheep Diseases; Thyroxine; Triiodothyronine | 1998 |
Effect of partial pancreatectomy on beta-cell mass in the remnant pancreas of Wistar fatty rats.
Topics: Animals; Blood Glucose; Cell Division; Diabetes Mellitus; Diabetes Mellitus, Type 2; Disease Models, Animal; Genotype; Hyperglycemia; Insulin; Insulin Resistance; Islets of Langerhans; Male; Niacinamide; Obesity; Pancreatectomy; Phenotype; Phlorhizin; Rats; Rats, Inbred WKY; Rats, Mutant Strains; Rats, Wistar; Rats, Zucker | 1998 |
Chronic hyperglycemia triggers loss of pancreatic beta cell differentiation in an animal model of diabetes.
Topics: Animals; Blood Glucose; Body Weight; Cell Differentiation; Chronic Disease; Diabetes Mellitus, Experimental; Disease Models, Animal; DNA Primers; Fatty Acids, Nonesterified; Humans; Hyperglycemia; Insulin; Islets of Langerhans; Male; Pancreatic Hormones; Phlorhizin; Rats; Rats, Sprague-Dawley; RNA, Messenger | 1999 |
Glucose toxicity and the development of diabetes in mice with muscle-specific inactivation of GLUT4.
Topics: Adipose Tissue; Age of Onset; Animals; Depression, Chemical; Diabetes Mellitus, Type 2; Disease Models, Animal; Glucose; Glucose Transporter Type 4; Hyperglycemia; Insulin; Insulin Infusion Systems; Insulin Resistance; Kidney Tubules; Liver; Male; Mice; Mice, Knockout; Monosaccharide Transport Proteins; Muscle Proteins; Muscle, Skeletal; Phlorhizin; Prediabetic State; Protein Transport | 2001 |
[Artificial induction of ketosis in lactating ewes using phlorizin infusions].
Topics: Animals; Disease Models, Animal; Female; Ketosis; Lactation; Methods; Phlorhizin; Pregnancy; Science; Sheep | 1976 |
[Effect of feeding, fasting and phlorhizin diabetes on the relationship between free fatty acids and glucose in sheep blood].
Topics: Animal Nutritional Physiological Phenomena; Animals; Blood Glucose; Diabetes Mellitus; Disease Models, Animal; Fasting; Fatty Acids; Male; Phlorhizin; Sheep | 1974 |