phlorhizin has been researched along with Diabetes Mellitus, Type 2 in 66 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (1.52) | 18.7374 |
| 1990's | 10 (15.15) | 18.2507 |
| 2000's | 11 (16.67) | 29.6817 |
| 2010's | 33 (50.00) | 24.3611 |
| 2020's | 11 (16.67) | 2.80 |
| Authors | Studies |
|---|---|
| Biller, SA; Deshpande, PP; Discenza, L; Ellsworth, BA; Flint, OP; Girotra, RN; Hagan, DL; Han, S; Humphreys, WG; Janovitz, EB; Khanna, A; McCann, PJ; Meng, W; Morgan, N; Morrison, EP; Nirschl, AA; Obermeier, MT; Patel, M; Pullockaran, A; Robertson, JG; Sher, PM; Taylor, JR; Wang, A; Washburn, WN; Wetterau, JR; Whaley, JM; Wu, G; Zahler, R | 1 |
| Washburn, WN | 1 |
| Almstead, ZY; Bardenhagen, J; Buhring, LM; DaCosta, CM; Goodwin, NC; Harrison, BA; Healy, J; Kimball, SD; Liu, Q; Mabon, R; Mseeh, F; Nouraldeen, A; Powell, DR; Rawlins, DB; Shadoan, MK; Wilson, AG; Xie, Y | 1 |
| Arai, M; Asami, J; Chino, Y; Fukasawa, Y; Hagima, N; Hashimoto-Tsuchiya, Y; Iida, I; Io, F; Kakinuma, H; Kawakita, Y; Miyata, N; Oi, T; Okumura-Kitajima, L; Takahashi, T; Takeuchi, H; Uchida, S; Yamamoto, D; Yamamoto, K | 1 |
| Chang, CC; Chao, YS; Chen, CT; Chiu, CH; Chu, KF; Hsiao, WC; Hsieh, CJ; Hsieh, TC; Huang, CY; Hung, MS; Lee, JC; Liu, YW; Song, JS; Tsai, CH; Wang, MH; Wu, SH; Yao, CH; Yeh, TK; Yuan, MC | 1 |
| Hagita, H; Higuchi, T; Ikeda, S; Kato, M; Kobayashi, T; Matsuoka, H; Morikawa, K; Murakata, M; Nishimoto, M; Ohmori, M; Ohtake, Y; Ozawa, K; Sato, T; Shimma, N; Suzuki, M; Taka, N; Takano, K; Yamaguchi, K; Yamamoto, K | 2 |
| Ahn, KH; Hagita, H; Ikeda, S; Kato, M; Kobayashi, T; Matsuoka, H; Morikawa, K; Nishimoto, M; Ohmori, M; Ohtake, Y; Ozawa, K; Sato, T; Suzuki, M; Taka, N; Takami, K; Takano, K; Yamaguchi, K; Yamaguchi, M; Yamamoto, K; Yeu, SY | 1 |
| Chang, WE; Chao, YS; Chen, CT; Chu, KF; Hsieh, TC; Huang, CY; Lee, JC; Song, JS; Wang, MH; Wu, SH; Yao, CH; Yeh, TK | 1 |
| Dore, TM; Jesus, AR; Machuqueiro, M; Marques, AP; Rauter, AP; Vila-Viçosa, D | 1 |
| Ahmad, K; Haider, K; Haider, MR; Pathak, A; Rohilla, A; Yar, MS | 1 |
| Kidoguchi, S; Kitada, K; Nakano, D; Nishiyama, A | 1 |
| Badwaik, HR; Kamdi, SP; Nakhate, KT; Raval, A | 1 |
| Delanaye, P; Grosch, S; Jouret, F; Scheen, AJ; Valdes-Socin, H | 1 |
| Wright, EM | 1 |
| Chen, J; Dong, Q; Qiu, Y; Si, X; Sun, T; Wang, J; Wu, W; Wu, Z; Zhang, R | 1 |
| Chhimwal, J; Kumar, S; Padwad, YS; Patial, V; Purohit, R; Singh, R | 1 |
| Agarwal, SM; Banerjee, SK; Borkar, RM; Das, AP; Kanwal, A; Pulimamidi, SS; Raju, B; Srinivas, R | 1 |
| Helvacı, B; Helvacı, Ö | 1 |
| Gerwin, LE; Leslie, BR; Taylor, SI | 1 |
| Bellion, P; Niederberger, KE; Tennant, DR | 1 |
| Fralick, M; Kesselheim, AS | 1 |
| Chung, SJ; Hwang, JY; Jang, TS; Kim, JK; Kim, KH; Seo, SO; So, HM; Yoon, SY; Yu, JS | 1 |
| Accili, D; Ishida, E; Kim-Muller, JY | 1 |
| Akamine, T; Kawanami, D; Matoba, K; Nagai, Y; Sango, K; Takeda, Y; Utsunomiya, K; Yokota, T | 1 |
| Artner, I; Axelsson, AS; Bagge, A; Costa, IG; Derry, JMJ; Eliasson, L; Fex, M; Gusmao, EG; Hänzelmann, S; Johnson, JD; Mahdi, T; Mecham, B; Millstein, J; Mulder, H; Nenonen, HA; Reinbothe, TM; Rosengren, AH; Salö, S; Shu, L; Singh, T; Spégel, P; Szabat, M; Tang, Y; Wang, J; Wendt, A; Wollheim, CB; Yang, X; Zhang, B; Zhang, E | 1 |
| Esatbeyoglu, T; Fischer, A; Lüersen, K; Rimbach, G; Schloesser, A; Schultheiß, G; Vollert, H | 1 |
| Jörgens, V | 1 |
| Ghezzi, C; Loo, DDF; Wright, EM | 1 |
| Rieg, T; Vallon, V | 1 |
| Cegieła, U; Folwarczna, J; Janas, A; Londzin, P; Pytlik, M; Siudak, S; Waligóra, A | 1 |
| Fang, M; Gao, Z; Hu, H; Jia, L; Li, Q; Wang, A; Wang, Z; Yi, K; Zhang, X | 1 |
| Bagler, G; Bhushan, S; Randhawa, V; Sharma, P | 1 |
| Araki, E; Goto, R; Igata, M; Kawasaki, S; Kawashima, J; Kitano, S; Kondo, T; Matsumura, T; Matsuyama, R; Miyagawa, K; Motoshima, H; Ono, K | 1 |
| Mauricio, D | 1 |
| Cai, W; Jiang, L; Liu, W; Liu, Y; Xie, Y; Zhao, G | 1 |
| Kakimoto, K; Katsuda, Y; Kemmochi, Y; Kume, S; Mera, Y; Motohashi, Y; Ohta, T; Sasase, T; Tadaki, H; Toyoda, K | 1 |
| Despa, F; Despa, S; Lambert, R; Margulies, KB; Peng, X; Srodulski, S | 1 |
| Henry, RR; Mudaliar, S; Polidori, D; Zambrowicz, B | 1 |
| Choi, CI | 1 |
| Gao, Z; Hu, H; Li, X; Liu, G; Mei, X; Wang, Z; Zhang, X; Zou, L | 1 |
| Thomson, SC; Vallon, V | 1 |
| Ito, J; Mashiko, S; Moriya, R; Seo, T; Shirakura, T | 1 |
| Del Prato, S | 1 |
| Cano Megías, M; González Albarrán, O; Pérez López, G | 1 |
| Dubrey, SW; Hardman, TC; Rutherford, P; Wierzbicki, AS | 1 |
| Hayashizaki, Y; Imamura, M; Kihara, R; Kobayashi, Y; Kurosaki, E; Noda, A; Qun, L; Sasamata, M; Shibasaki, M; Tahara, A; Takasu, T; Tomiyama, H; Yamajuku, D; Yokono, M | 1 |
| Simonyi, G | 1 |
| Sheridan, C | 1 |
| Bosch, RR; Hermus, AR; Janssen, SW; Martens J M, G; Olthaar, A; Span, PN; Sweep, CC; van Emst-de Vries, SE; Willems, PH | 1 |
| Gavrilova, O; Jou, W; Kim, H; LeRoith, D; Setser, J; Sun, H; Yakar, S; Zhang, Y; Zhao, H | 1 |
| Berthault, MF; Cerasi, E; Donath, MY; Kaiser, N; Kargar, C; Ktorza, A; Oprescu, AI; Uçkaya, G; Yuli, M | 1 |
| Bronson, SK; Gardner, TW; Hong, EG; Jun, JY; Jung, DY; Kim, JH; Kim, JK; Ko, HJ; Ma, Z; Sumner, AD; Vary, TC; Zhang, Z | 1 |
| Allen, LE; Caro, JF; Colberg, J; Considine, RV; Lanza-Jacoby, S; Morales, LM; Nyce, MR; Serrano, J; Triester, S | 1 |
| Mizuno, A; Noma, Y; Sano, T; Shima, K; Zhu, M | 1 |
| Efendić, S; Kawano, Y; Krook, A; Roth, RA; Song, XM; Wallberg-Henriksson, H; Zierath, JR | 1 |
| Buongiorno, A; Giaccari, A; Maroccia, E; Morviducci, L; Pastore, L; Sbraccia, P; Tamburrano, G; Zorretta, D | 1 |
| Kuwajima, M; Murakami, T; Ogino, T; Shima, K; Zhu, M | 1 |
| Fujimiya, M; Fujita, Y; Hidaka, H; Kashiwagi, A; Kikkawa, R; Kojima, H | 1 |
| Efendic, S; Kawano, Y; Krook, A; Roth, RA; Ryder, JW; Song, XM; Wallberg-Henriksson, H; Zierath, JR | 1 |
| Federici, M; Giaccari, A; Giovannone, B; Hribal, ML; Lauro, D; Lauro, R; Morviducci, L; Pastore, L; Sesti, G; Tamburrano, G | 1 |
| Efendic, S; Hong-Lie, C; Khan, A; Ling, ZC; Ostenson, CG | 1 |
| Dong, J; Fillmore, JJ; Kahn, BB; Kahn, CR; Kim, JK; Kotani, K; Peroni, OD; Perret, P; Shulman, GI; Zisman, A; Zong, H | 1 |
| Bailbé, D; Blondel, O; Portha, B; Serradas, P | 1 |
| Bailbe, D; Blondel, O; Portha, B | 1 |
| Lauglin, MR; Rossetti, L | 1 |
15 review(s) available for phlorhizin and Diabetes Mellitus, Type 2
| Article | Year |
|---|---|
Development of the renal glucose reabsorption inhibitors: a new mechanism for the pharmacotherapy of diabetes mellitus type 2.
Topics: Animals; Clinical Trials as Topic; Diabetes Mellitus, Type 2; Drug Evaluation, Preclinical; Glucose; Glucosides; Humans; Hypoglycemic Agents; Kidney; Sodium-Glucose Transporter 2 Inhibitors | 2009 |
Synthetic strategy and SAR studies of C-glucoside heteroaryls as SGLT2 inhibitor: A review.
Topics: Animals; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Glucosides; Humans; Hypoglycemic Agents; Molecular Structure; Sodium-Glucose Transporter 2; Sodium-Glucose Transporter 2 Inhibitors; Structure-Activity Relationship | 2019 |
Sodium/glucose cotransporter 2 and renoprotection: From the perspective of energy regulation and water conservation.
Topics: Administration, Oral; Body Water; Diabetes Mellitus, Type 2; Diuresis; Energy Metabolism; Glucose; Humans; Hypoglycemic Agents; Kidney; Kidney Tubules, Proximal; Malus; Osmosis; Phlorhizin; Phytotherapy; Sodium; Sodium-Glucose Transporter 2 | 2021 |
SGLT2 Inhibitors: Physiology and Pharmacology.
Topics: Diabetes Mellitus, Type 2; Glucose; Humans; Phlorhizin; Sodium-Glucose Transport Proteins; Sodium-Glucose Transporter 2 Inhibitors | 2021 |
SGLT2 Inhibitors as a Therapeutic Option for Diabetic Nephropathy.
Topics: Animals; Cardiovascular Diseases; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Humans; Phlorhizin; Randomized Controlled Trials as Topic; Sodium-Glucose Transporter 2; Sodium-Glucose Transporter 2 Inhibitors | 2017 |
Physiology of renal glucose handling via SGLT1, SGLT2 and GLUT2.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Type 2; Drug Design; Glucose; Glucose Transporter Type 2; Glycosuria; HEK293 Cells; Homeostasis; Humans; Hypoglycemic Agents; Kidney; Kidney Tubules; Kidney Tubules, Proximal; Mice; Mice, Knockout; Phlorhizin; Sodium-Glucose Transporter 1; Sodium-Glucose Transporter 2; Sodium-Glucose Transporter 2 Inhibitors | 2018 |
Development of SGLT1 and SGLT2 inhibitors.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diabetic Ketoacidosis; Disease Models, Animal; Drug Design; Glucose; Humans; Intestinal Mucosa; Kidney; Mice; Mutation; Phlorhizin; Sodium-Glucose Transporter 1; Sodium-Glucose Transporter 2; Sodium-Glucose Transporter 2 Inhibitors | 2018 |
[Sodium-glucose co-transporter-2 inhibitors: from the bark of apple trees and familial renal glycosuria to the treatment of type 2 diabetes mellitus].
Topics: Adsorption; Animals; Benzhydryl Compounds; Biological Transport, Active; Canagliflozin; Clinical Trials, Phase III as Topic; Diabetes Mellitus, Type 2; Drugs, Investigational; Glucose; Glucosides; Glycosides; Glycosuria; Glycosuria, Renal; Humans; Hypoglycemic Agents; Kidney Tubules, Proximal; Malus; Phlorhizin; Phytotherapy; Plant Bark; Rats; Sodium-Glucose Transporter 2; Sodium-Glucose Transporter 2 Inhibitors; Thiophenes; Treatment Outcome | 2013 |
Design of SGLT2 Inhibitors for the Treatment of Type 2 Diabetes: A History Driven by Biology to Chemistry.
Topics: Benzhydryl Compounds; Diabetes Mellitus, Type 2; Drug Design; Drug Discovery; Glucosides; Glycosides; History, 20th Century; History, 21st Century; Humans; Hypoglycemic Agents; Monosaccharides; Phlorhizin; Sodium-Glucose Transporter 2; Sodium-Glucose Transporter 2 Inhibitors; Structure-Activity Relationship | 2015 |
Sodium-Glucose Cotransporter Inhibitors: Effects on Renal and Intestinal Glucose Transport: From Bench to Bedside.
Topics: Animals; Biological Transport; Diabetes Mellitus, Type 2; Glucose; Glycosuria; Humans; Hypoglycemic Agents; Insulin Resistance; Intestinal Mucosa; Kidney; Phlorhizin; Renal Elimination; Sodium-Glucose Transport Proteins; Sodium-Glucose Transporter 2; Sodium-Glucose Transporter 2 Inhibitors | 2015 |
Sodium-Glucose Cotransporter 2 (SGLT2) Inhibitors from Natural Products: Discovery of Next-Generation Antihyperglycemic Agents.
Topics: Animals; Diabetes Mellitus, Type 2; Glucose; Herbal Medicine; Humans; Hypoglycemic Agents; Phlorhizin; Phytotherapy; Sodium-Glucose Transporter 2; Sodium-Glucose Transporter 2 Inhibitors | 2016 |
Targeting renal glucose reabsorption to treat hyperglycaemia: the pleiotropic effects of SGLT2 inhibition.
Topics: Diabetes Mellitus, Type 2; Glucose; Humans; Hyperglycemia; Insulin Resistance; Kidney; Phlorhizin; Sodium-Glucose Transporter 2; Sodium-Glucose Transporter 2 Inhibitors | 2017 |
[Sodium-glucose cotransporter type 2 inhibitors (SGLT2): from familial renal glucosuria to the treatment of type 2 diabetes mellitus].
Topics: Absorption; Animals; Benzhydryl Compounds; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Dogs; Double-Blind Method; Gluconeogenesis; Glucose; Glucosides; Glycosuria, Renal; Homeostasis; Humans; Hypoglycemic Agents; Kidney; Kidney Tubules, Proximal; Mice; Phlorhizin; Randomized Controlled Trials as Topic; Sodium-Glucose Transporter 1; Sodium-Glucose Transporter 2; Sodium-Glucose Transporter 2 Inhibitors | 2010 |
Sodium-glucose co-transporter 2 inhibitors: from apple tree to 'Sweet Pee'.
Topics: Blood Glucose; Diabetes Mellitus, Type 2; Humans; Phlorhizin; Sodium-Glucose Transporter 2; Sodium-Glucose Transporter 2 Inhibitors; Subcellular Fractions | 2010 |
[New possibility in the oral glucose lowering treatment of type 2 diabetes mellitus: sodium-glucose co-transporter-2 inhibitors].
Topics: Administration, Oral; Benzhydryl Compounds; Blood Glucose; Canagliflozin; Diabetes Mellitus, Type 2; Glucosides; Humans; Hypoglycemic Agents; Phlorhizin; Sodium-Glucose Transporter 2 Inhibitors; Thiophenes | 2012 |
51 other study(ies) available for phlorhizin and Diabetes Mellitus, Type 2
| Article | Year |
|---|---|
Discovery of dapagliflozin: a potent, selective renal sodium-dependent glucose cotransporter 2 (SGLT2) inhibitor for the treatment of type 2 diabetes.
Topics: Administration, Oral; Animals; Benzhydryl Compounds; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Glucosides; Humans; Hypoglycemic Agents; Kidney; Rats; Sodium-Glucose Transporter 2; Sodium-Glucose Transporter 2 Inhibitors; Stereoisomerism | 2008 |
Novel L-xylose derivatives as selective sodium-dependent glucose cotransporter 2 (SGLT2) inhibitors for the treatment of type 2 diabetes.
Topics: Animals; Diabetes Mellitus, Type 2; Drug Discovery; Glucose; Humans; Mice; Sodium-Glucose Transporter 2 Inhibitors; Substrate Specificity; Xylose | 2009 |
(1S)-1,5-anhydro-1-[5-(4-ethoxybenzyl)-2-methoxy-4-methylphenyl]-1-thio-D-glucitol (TS-071) is a potent, selective sodium-dependent glucose cotransporter 2 (SGLT2) inhibitor for type 2 diabetes treatment.
Topics: Animals; Biological Availability; Blood Proteins; Caco-2 Cells; Cell Membrane Permeability; CHO Cells; Cricetinae; Cricetulus; Diabetes Mellitus, Type 2; Dogs; Hepatocytes; Humans; Hypoglycemic Agents; In Vitro Techniques; Microsomes, Liver; Protein Binding; Rats; Rats, Zucker; Sodium-Glucose Transporter 2; Sodium-Glucose Transporter 2 Inhibitors; Sorbitol; Structure-Activity Relationship; Tissue Distribution | 2010 |
Discovery of novel N-β-D-xylosylindole derivatives as sodium-dependent glucose cotransporter 2 (SGLT2) inhibitors for the management of hyperglycemia in diabetes.
Topics: Animals; CHO Cells; Cricetinae; Cricetulus; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Glucose; Glucosides; Humans; Hyperglycemia; Hypoglycemic Agents; Indoles; Male; Mice; Mice, Inbred ICR; Rats; Rats, Sprague-Dawley; Sodium-Glucose Transporter 2 Inhibitors; Structure-Activity Relationship; Xylose | 2011 |
5a-Carba-β-D-glucopyranose derivatives as novel sodium-dependent glucose cotransporter 2 (SGLT2) inhibitors for the treatment of type 2 diabetes.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Glucose; Male; Mice; Mice, Obese; Molecular Conformation; Molecular Sequence Data; Sodium-Glucose Transporter 2; Sodium-Glucose Transporter 2 Inhibitors; Stereoisomerism; Structure-Activity Relationship; Tissue Distribution | 2011 |
C-Aryl 5a-carba-β-d-glucopyranosides as novel sodium glucose cotransporter 2 (SGLT2) inhibitors for the treatment of type 2 diabetes.
Topics: Administration, Oral; Animals; Area Under Curve; Blood Glucose; Cyclohexanols; Diabetes Mellitus, Type 2; Glucose; Hypoglycemic Agents; Mice; Mice, Obese; Sodium-Glucose Transporter 2; Sodium-Glucose Transporter 2 Inhibitors; Structure-Activity Relationship | 2012 |
Discovery of tofogliflozin, a novel C-arylglucoside with an O-spiroketal ring system, as a highly selective sodium glucose cotransporter 2 (SGLT2) inhibitor for the treatment of type 2 diabetes.
Topics: Animals; Benzhydryl Compounds; Diabetes Mellitus, Type 2; Glucosides; Humans; Macaca fascicularis; Magnetic Resonance Spectroscopy; Mice; Mice, Inbred ICR; Models, Molecular; Sodium-Glucose Transporter 2; Sodium-Glucose Transporter 2 Inhibitors; Spectrometry, Mass, Electrospray Ionization | 2012 |
N-Indolylglycosides bearing modifications at the glucose C6-position as sodium-dependent glucose co-transporter 2 inhibitors.
Topics: Animals; CHO Cells; Cricetulus; Diabetes Mellitus, Type 2; Glucose; Glycosides; Humans; Hypoglycemic Agents; Rats, Sprague-Dawley; Small Molecule Libraries; Sodium-Glucose Transporter 2; Sodium-Glucose Transporter 2 Inhibitors | 2016 |
Targeting Type 2 Diabetes with C-Glucosyl Dihydrochalcones as Selective Sodium Glucose Co-Transporter 2 (SGLT2) Inhibitors: Synthesis and Biological Evaluation.
Topics: Chalcones; Diabetes Mellitus, Type 2; Glucosides; HEK293 Cells; Humans; Membranes, Artificial; Molecular Docking Simulation; Phosphatidylcholines; Sodium-Glucose Transporter 1; Sodium-Glucose Transporter 2; Sodium-Glucose Transporter 2 Inhibitors | 2017 |
Ameliorative potential of phloridzin in type 2 diabetes-induced memory deficits in rats.
Topics: Acetylcholine; Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Humans; Male; Maze Learning; Memory; Memory Disorders; Molecular Docking Simulation; Nerve Growth Factors; Oxidative Stress; Phlorhizin; Rats; Receptor, Muscarinic M1; Scopolamine; Streptozocin; Synaptic Transmission; Up-Regulation | 2021 |
[From the discovery of phlorizin (a Belgian story) to SGLT2 inhibitors].
Topics: Belgium; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Phlorhizin; Sodium-Glucose Transporter 2; Sodium-Glucose Transporter 2 Inhibitors | 2022 |
Docosahexaenoic Acid Ester of Phloridzin Reduces Inflammation and Insulin Resistance
Topics: AMP-Activated Protein Kinases; Cell Line; Diabetes Mellitus, Type 2; Docosahexaenoic Acids; Esters; Glucose; Humans; Inflammation; Insulin; Insulin Resistance; Muscle Fibers, Skeletal; Palmitic Acid; Phlorhizin | 2022 |
Phloretin and phlorizin mitigates inflammatory stress and alleviate adipose and hepatic insulin resistance by abrogating PPARγ S273-Cdk5 interaction in type 2 diabetic mice.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Insulin Resistance; Mice; Obesity; Phloretin; Phlorhizin; PPAR gamma | 2023 |
A pharmacokinetic study to correlate the hypoglycemic effect of phlorizin in rats: Identification of metabolites as inhibitors of sodium/glucose cotransporters.
Topics: Animals; Chromatography, High Pressure Liquid; Diabetes Mellitus, Type 2; Glucose; Hypoglycemic Agents; Phlorhizin; Rats; Rats, Sprague-Dawley; Sodium; Sodium-Glucose Transporter 2; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry | 2023 |
A Story of Serendipities: From Phlorizin to Gliflozins.
Topics: Animals; Diabetes Mellitus, Type 2; Dogs; Hypoglycemic Agents; Insulin; Phlorhizin; Sodium-Glucose Transporter 2 Inhibitors | 2023 |
Sodium-Glucose Cotransporter-2 Inhibitors: Lack of a Complete History Delays Diagnosis.
Topics: Delayed Diagnosis; Diabetes Mellitus, Type 2; Drug Approval; Glycosuria, Renal; History, 19th Century; History, 20th Century; History, 21st Century; Humans; Ketosis; Phlorhizin; Sodium-Glucose Transporter 2 Inhibitors; United States; United States Food and Drug Administration | 2019 |
Dietary intake of phloridzin from natural occurrence in foods.
Topics: Diabetes Mellitus, Type 2; Food Analysis; Humans; Models, Biological; Phlorhizin | 2020 |
Using real-world safety data in regulatory approval decisions: Sotagliflozin and the risk of diabetic ketoacidosis.
Topics: Clinical Trials as Topic; Data Collection; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diabetic Ketoacidosis; Drug Approval; Glycosides; Humans; Phlorhizin; Sodium-Glucose Transporter 2 Inhibitors; Treatment Outcome; United States; United States Food and Drug Administration | 2020 |
Phloridzin Acts as an Inhibitor of Protein-Tyrosine Phosphatase MEG2 Relevant to Insulin Resistance.
Topics: 3T3 Cells; Adipocytes; Animals; Cell Differentiation; Cell Line; Diabetes Mellitus, Type 2; Glucose; Hypoglycemic Agents; Insulin; Insulin Resistance; Mice; Palmitates; Phlorhizin; Phosphorylation; Protein Tyrosine Phosphatases; Protein Tyrosine Phosphatases, Non-Receptor; Signal Transduction | 2021 |
Pair Feeding, but Not Insulin, Phloridzin, or Rosiglitazone Treatment, Curtails Markers of β-Cell Dedifferentiation in
Topics: Animals; Biomarkers; Blood Glucose; Cell Dedifferentiation; Diabetes Mellitus, Type 2; Disease Models, Animal; Eating; Humans; Hypoglycemic Agents; Insulin; Insulin-Secreting Cells; Mice; Phlorhizin; Rosiglitazone; Thiazolidinediones | 2017 |
Sox5 regulates beta-cell phenotype and is reduced in type 2 diabetes.
Topics: Animals; Calcium; Calcium Channels; Chromatin; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Exocytosis; Female; Gene Expression Regulation; Humans; Insulin; Insulin-Secreting Cells; Islets of Langerhans; Male; Mice; Mice, Inbred C57BL; Oligonucleotide Array Sequence Analysis; Phenotype; Phlorhizin; Rats; RNA, Small Interfering; SOXD Transcription Factors; Valproic Acid | 2017 |
Antidiabetic Properties of an Apple/Kale Extract In Vitro, In Situ, and in Mice Fed a Western-Type Diet.
Topics: alpha-Glucosidases; Animals; Blood Glucose; Brassica; Diabetes Mellitus, Type 2; Diet, High-Fat; Female; Flavonoids; Glucose Tolerance Test; Humans; Hypoglycemic Agents; Male; Malus; Mice; Mice, Inbred C57BL; Phlorhizin; Plant Extracts; Sodium-Glucose Transporter 1 | 2017 |
The roots of SGLT inhibition: Laurent-Guillaume de Koninck, Jean Servais Stas and Freiherr Josef von Mering.
Topics: Belgium; Chemistry, Pharmaceutical; Diabetes Mellitus, Type 2; Drug Discovery; Germany; History, 19th Century; History, 20th Century; History, 21st Century; Humans; Insulin; Phlorhizin; Sodium-Glucose Transporter 2 Inhibitors | 2019 |
Phloridzin, an Apple Polyphenol, Exerted Unfavorable Effects on Bone and Muscle in an Experimental Model of Type 2 Diabetes in Rats.
Topics: Animals; Bone and Bones; Bone Density; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Diet, High-Fat; Female; Hyperglycemia; Hypoglycemic Agents; Malus; Muscle, Skeletal; Phloretin; Phlorhizin; Polyphenols; Rats; Rats, Wistar | 2018 |
Comparative oral and intravenous pharmacokinetics of phlorizin in rats having type 2 diabetes and in normal rats based on phase II metabolism.
Topics: Administration, Oral; Animals; Area Under Curve; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Half-Life; Injections, Intravenous; Male; Molecular Structure; Phlorhizin; Random Allocation; Rats; Rats, Wistar; Research Design; Specific Pathogen-Free Organisms | 2019 |
Identification of key nodes of type 2 diabetes mellitus protein interactome and study of their interactions with phloridzin.
Topics: Binding Sites; Computational Biology; Diabetes Mellitus, Type 2; E1A-Associated p300 Protein; Gene Expression Profiling; Genetic Association Studies; Humans; Mitogen-Activated Protein Kinase 1; Molecular Conformation; Molecular Docking Simulation; Molecular Dynamics Simulation; Molecular Sequence Annotation; Phlorhizin; Protein Binding; Protein Interaction Domains and Motifs; Protein Interaction Mapping; Protein Interaction Maps; Proteome; Smad2 Protein | 2013 |
Effects of combination therapy with vildagliptin and valsartan in a mouse model of type 2 diabetes.
Topics: Adamantane; Adiponectin; Angiotensin II Type 1 Receptor Blockers; Animals; Blood Glucose; Cytokines; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Dipeptidyl-Peptidase IV Inhibitors; Disease Models, Animal; Drug Therapy, Combination; Fatty Liver; Homeodomain Proteins; Inflammation; Insulin; Insulin Resistance; Insulin Secretion; Insulin-Secreting Cells; Mice; Mice, Inbred C57BL; Nitriles; Phlorhizin; Pyrrolidines; Tetrazoles; Trans-Activators; Valine; Valsartan; Vildagliptin | 2013 |
Contribution of hyperglycemia on diabetic complications in obese type 2 diabetic SDT fatty rats: effects of SGLT inhibitor phlorizin.
Topics: Albuminuria; Animals; Blood Glucose; Diabetes Complications; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Diabetic Neuropathies; Diabetic Retinopathy; Disease Models, Animal; Female; Hyperglycemia; Kidney Tubules; Phlorhizin; Rats, Inbred Strains; Rats, Sprague-Dawley; Sodium-Glucose Transport Proteins | 2015 |
Intracellular Na+ Concentration ([Na+]i) Is Elevated in Diabetic Hearts Due to Enhanced Na+-Glucose Cotransport.
Topics: Aged; Animals; Diabetes Mellitus, Type 2; Diabetic Cardiomyopathies; Disease Models, Animal; Female; Heart Failure; Humans; Male; Middle Aged; Myocardium; Myocytes, Cardiac; Phlorhizin; Rats, Sprague-Dawley; Sodium; Sodium-Glucose Transporter 1; Time Factors; Up-Regulation | 2015 |
Insulin Sensitivity-Enhancing Activity of Phlorizin Is Associated with Lipopolysaccharide Decrease and Gut Microbiota Changes in Obese and Type 2 Diabetes (db/db) Mice.
Topics: Animals; Body Weight; Diabetes Mellitus, Type 2; Energy Intake; Fatty Acids, Volatile; Gastrointestinal Microbiome; Hypoglycemic Agents; Insulin Resistance; Lipopolysaccharides; Male; Mice, Mutant Strains; Mice, Obese; Phlorhizin | 2016 |
Activation of sodium-glucose cotransporter 1 ameliorates hyperglycemia by mediating incretin secretion in mice.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Type 2; Gastric Inhibitory Polypeptide; Glucagon-Like Peptide 1; Glucose; Glucose Tolerance Test; Hyperglycemia; Intestine, Large; Male; Methylglucosides; Mice; Mice, Inbred C57BL; Phlorhizin; Random Allocation; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sodium-Glucose Transporter 1 | 2009 |
Role of glucotoxicity and lipotoxicity in the pathophysiology of Type 2 diabetes mellitus and emerging treatment strategies.
Topics: Animals; B-Lymphocytes; Diabetes Mellitus, Type 2; Disease Progression; Genetic Predisposition to Disease; Glucose; Humans; Lipid Metabolism; Phlorhizin; Rats; RNA, Messenger; TCF Transcription Factors; Thiazolidinediones; Transcription Factor 7-Like 2 Protein | 2009 |
Pharmacological profile of ipragliflozin (ASP1941), a novel selective SGLT2 inhibitor, in vitro and in vivo.
Topics: Animals; Blood Glucose; Carbohydrate Metabolism; CHO Cells; Cricetinae; Cricetulus; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Gastrointestinal Tract; Glucosides; Humans; Hypoglycemic Agents; Insulin; Male; Mice; Mice, Inbred ICR; Phlorhizin; Rats; Rats, Sprague-Dawley; Sodium-Glucose Transporter 1; Sodium-Glucose Transporter 2 Inhibitors; Thiophenes | 2012 |
SGLT2 inhibitors race to enter type-2 diabetes market.
Topics: Animals; Clinical Trials as Topic; Diabetes Mellitus, Type 2; Drug Approval; Drug Discovery; Humans; Hypoglycemic Agents; Insulin-Secreting Cells; Marketing; Phlorhizin; Sodium-Glucose Transporter 1; Sodium-Glucose Transporter 2; Sodium-Glucose Transporter 2 Inhibitors; United States; United States Food and Drug Administration | 2012 |
Exploring levels of hexosamine biosynthesis pathway intermediates and protein kinase C isoforms in muscle and fat tissue of Zucker Diabetic Fatty rats.
Topics: Adipose Tissue; Aging; Animals; Blood Glucose; Blotting, Western; Diabetes Mellitus, Type 2; Hexosamines; Insulin; Isoenzymes; Male; Muscle, Skeletal; Nucleotides; Phlorhizin; Protein Kinase C; Rats; Rats, Zucker; Uridine Diphosphate N-Acetylgalactosamine; Uridine Diphosphate N-Acetylglucosamine | 2003 |
Phloridzin improves hyperglycemia but not hepatic insulin resistance in a transgenic mouse model of type 2 diabetes.
Topics: Adipose Tissue; Animals; Blood Glucose; Body Composition; Diabetes Mellitus, Type 2; Disease Models, Animal; Energy Intake; Hyperglycemia; Insulin Resistance; Liver; Male; Mice; Mice, Transgenic; Phlorhizin | 2004 |
Dynamic changes in {beta}-cell mass and pancreatic insulin during the evolution of nutrition-dependent diabetes in psammomys obesus: impact of glycemic control.
Topics: Animals; Diabetes Mellitus, Type 2; Diet; Diet, Diabetic; Energy Metabolism; Gerbillinae; Insulin; Insulin Secretion; Islets of Langerhans; Kinetics; Phlorhizin; Time Factors | 2005 |
Nonobese, insulin-deficient Ins2Akita mice develop type 2 diabetes phenotypes including insulin resistance and cardiac remodeling.
Topics: Adipose Tissue; Animals; Blood Glucose; Diabetes Mellitus, Type 2; Energy Metabolism; Fatty Acids; Glucose; Glucose Clamp Technique; Glucose Transporter Type 4; Hyperglycemia; Hypertrophy, Left Ventricular; Insulin; Insulin Resistance; Liver; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Muscle, Skeletal; Oxygen Consumption; Phlorhizin; Protein Kinase C-epsilon; Triglycerides; Ventricular Remodeling | 2007 |
Protein kinase C is increased in the liver of humans and rats with non-insulin-dependent diabetes mellitus: an alteration not due to hyperglycemia.
Topics: Adult; Animals; Diabetes Mellitus, Type 2; Diglycerides; Female; Humans; Insulin; Insulin Resistance; Isoenzymes; Liver; Male; Middle Aged; Obesity; Phlorhizin; Protein Kinase C; Rats; Receptor, Insulin | 1995 |
Poor capacity for proliferation of pancreatic beta-cells in Otsuka-Long-Evans-Tokushima Fatty rat: a model of spontaneous NIDDM.
Topics: Animals; Blood Glucose; Body Weight; Cell Division; Diabetes Mellitus; Diabetes Mellitus, Type 2; Female; Humans; Hyperglycemia; Islets of Langerhans; Male; Niacinamide; Obesity; Pancreatectomy; Phlorhizin; Rats; Rats, Mutant Strains | 1996 |
Improved glucose tolerance restores insulin-stimulated Akt kinase activity and glucose transport in skeletal muscle from diabetic Goto-Kakizaki rats.
Topics: Animals; Biological Transport; Blood Glucose; Diabetes Mellitus, Type 2; Glucose; Glucose Tolerance Test; Insulin; Insulin Resistance; Male; Muscle, Skeletal; Phlorhizin; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Rats; Rats, Mutant Strains | 1997 |
Relative contribution of glycogenolysis and gluconeogenesis to hepatic glucose production in control and diabetic rats. A re-examination in the presence of euglycaemia.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Disease Models, Animal; Fatty Acids, Nonesterified; Gluconeogenesis; Glucose; Glucose Clamp Technique; Glucose-6-Phosphate; Hyperglycemia; Hyperinsulinism; Hypoglycemic Agents; Insulin; Liver; Liver Glycogen; Male; Phlorhizin; Rats; Rats, Sprague-Dawley; Reference Values; Sodium Chloride | 1998 |
Effect of partial pancreatectomy on beta-cell mass in the remnant pancreas of Wistar fatty rats.
Topics: Animals; Blood Glucose; Cell Division; Diabetes Mellitus; Diabetes Mellitus, Type 2; Disease Models, Animal; Genotype; Hyperglycemia; Insulin; Insulin Resistance; Islets of Langerhans; Male; Niacinamide; Obesity; Pancreatectomy; Phenotype; Phlorhizin; Rats; Rats, Inbred WKY; Rats, Mutant Strains; Rats, Wistar; Rats, Zucker | 1998 |
Increased intestinal glucose absorption and postprandial hyperglycaemia at the early step of glucose intolerance in Otsuka Long-Evans Tokushima Fatty rats.
Topics: Animals; Diabetes Mellitus; Diabetes Mellitus, Type 2; Food; Gene Expression; Glucose; Glucose Intolerance; Glucose Tolerance Test; Hyperglycemia; Insulin Resistance; Intestinal Absorption; Intestines; Male; Monosaccharide Transport Proteins; Obesity; Phlorhizin; Rats; Rats, Long-Evans; Xylose | 1998 |
Muscle fiber type-specific defects in insulin signal transduction to glucose transport in diabetic GK rats.
Topics: 3-O-Methylglucose; Animals; Biological Transport; Body Weight; Diabetes Mellitus, Type 2; Gene Expression Regulation; Glucose; Glucose Transporter Type 4; Glycogen Synthase; Insulin; Insulin Receptor Substrate Proteins; Monosaccharide Transport Proteins; Muscle Fibers, Skeletal; Muscle Proteins; Muscle, Skeletal; Phlorhizin; Phosphatidylinositol 3-Kinases; Phosphoproteins; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Rats; Rats, Inbred Strains; Rats, Wistar; Signal Transduction; Species Specificity | 1999 |
Evidence for glucose/hexosamine in vivo regulation of insulin/IGF-I hybrid receptor assembly.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Glucosamine; Insulin; Insulin-Like Growth Factor I; Kinetics; Male; Muscle, Skeletal; Phlorhizin; Protein Multimerization; Rats; Rats, Sprague-Dawley; Receptor, IGF Type 1; Receptor, Insulin; Reference Values | 1999 |
Hyperglycemia contributes to impaired insulin response in GK rat islets.
Topics: Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Glucose; Glucose-6-Phosphatase; Hyperglycemia; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Male; Oxidation-Reduction; Phlorhizin; Rats; Rats, Wistar | 2001 |
Glucose toxicity and the development of diabetes in mice with muscle-specific inactivation of GLUT4.
Topics: Adipose Tissue; Age of Onset; Animals; Depression, Chemical; Diabetes Mellitus, Type 2; Disease Models, Animal; Glucose; Glucose Transporter Type 4; Hyperglycemia; Insulin; Insulin Infusion Systems; Insulin Resistance; Kidney Tubules; Liver; Male; Mice; Mice, Knockout; Monosaccharide Transport Proteins; Muscle Proteins; Muscle, Skeletal; Phlorhizin; Prediabetic State; Protein Transport | 2001 |
Abnormal B-cell function in rats with non-insulin-dependent diabetes induced by neonatal streptozotocin: effect of in vivo insulin, phlorizin, or vanadate treatments.
Topics: Animals; Arginine; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Glucose; In Vitro Techniques; Insulin; Insulin Secretion; Male; Pancreas; Phlorhizin; Rats; Rats, Inbred Strains; Vanadates | 1991 |
Insulin resistance in rats with non-insulin-dependent diabetes induced by neonatal (5 days) streptozotocin: evidence for reversal following phlorizin treatment.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Glucose Clamp Technique; Glucose Tolerance Test; Insulin; Insulin Resistance; Insulin Secretion; Kinetics; Phlorhizin; Rats; Rats, Inbred Strains; Reference Values | 1990 |
Correction of chronic hyperglycemia with vanadate, but not with phlorizin, normalizes in vivo glycogen repletion and in vitro glycogen synthase activity in diabetic skeletal muscle.
Topics: Animals; Chronic Disease; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Glucose Clamp Technique; Glycogen; Glycogen Synthase; Hyperglycemia; Insulin; Liver; Male; Muscles; Phlorhizin; Rats; Rats, Inbred Strains; Vanadates | 1989 |