Page last updated: 2024-08-16

phlorhizin and Diabetes Mellitus, Adult-Onset

phlorhizin has been researched along with Diabetes Mellitus, Adult-Onset in 66 studies

Research

Studies (66)

TimeframeStudies, this research(%)All Research%
pre-19901 (1.52)18.7374
1990's10 (15.15)18.2507
2000's11 (16.67)29.6817
2010's33 (50.00)24.3611
2020's11 (16.67)2.80

Authors

AuthorsStudies
Biller, SA; Deshpande, PP; Discenza, L; Ellsworth, BA; Flint, OP; Girotra, RN; Hagan, DL; Han, S; Humphreys, WG; Janovitz, EB; Khanna, A; McCann, PJ; Meng, W; Morgan, N; Morrison, EP; Nirschl, AA; Obermeier, MT; Patel, M; Pullockaran, A; Robertson, JG; Sher, PM; Taylor, JR; Wang, A; Washburn, WN; Wetterau, JR; Whaley, JM; Wu, G; Zahler, R1
Washburn, WN1
Almstead, ZY; Bardenhagen, J; Buhring, LM; DaCosta, CM; Goodwin, NC; Harrison, BA; Healy, J; Kimball, SD; Liu, Q; Mabon, R; Mseeh, F; Nouraldeen, A; Powell, DR; Rawlins, DB; Shadoan, MK; Wilson, AG; Xie, Y1
Arai, M; Asami, J; Chino, Y; Fukasawa, Y; Hagima, N; Hashimoto-Tsuchiya, Y; Iida, I; Io, F; Kakinuma, H; Kawakita, Y; Miyata, N; Oi, T; Okumura-Kitajima, L; Takahashi, T; Takeuchi, H; Uchida, S; Yamamoto, D; Yamamoto, K1
Chang, CC; Chao, YS; Chen, CT; Chiu, CH; Chu, KF; Hsiao, WC; Hsieh, CJ; Hsieh, TC; Huang, CY; Hung, MS; Lee, JC; Liu, YW; Song, JS; Tsai, CH; Wang, MH; Wu, SH; Yao, CH; Yeh, TK; Yuan, MC1
Hagita, H; Higuchi, T; Ikeda, S; Kato, M; Kobayashi, T; Matsuoka, H; Morikawa, K; Murakata, M; Nishimoto, M; Ohmori, M; Ohtake, Y; Ozawa, K; Sato, T; Shimma, N; Suzuki, M; Taka, N; Takano, K; Yamaguchi, K; Yamamoto, K2
Ahn, KH; Hagita, H; Ikeda, S; Kato, M; Kobayashi, T; Matsuoka, H; Morikawa, K; Nishimoto, M; Ohmori, M; Ohtake, Y; Ozawa, K; Sato, T; Suzuki, M; Taka, N; Takami, K; Takano, K; Yamaguchi, K; Yamaguchi, M; Yamamoto, K; Yeu, SY1
Chang, WE; Chao, YS; Chen, CT; Chu, KF; Hsieh, TC; Huang, CY; Lee, JC; Song, JS; Wang, MH; Wu, SH; Yao, CH; Yeh, TK1
Dore, TM; Jesus, AR; Machuqueiro, M; Marques, AP; Rauter, AP; Vila-Viçosa, D1
Ahmad, K; Haider, K; Haider, MR; Pathak, A; Rohilla, A; Yar, MS1
Kidoguchi, S; Kitada, K; Nakano, D; Nishiyama, A1
Badwaik, HR; Kamdi, SP; Nakhate, KT; Raval, A1
Delanaye, P; Grosch, S; Jouret, F; Scheen, AJ; Valdes-Socin, H1
Wright, EM1
Chen, J; Dong, Q; Qiu, Y; Si, X; Sun, T; Wang, J; Wu, W; Wu, Z; Zhang, R1
Chhimwal, J; Kumar, S; Padwad, YS; Patial, V; Purohit, R; Singh, R1
Agarwal, SM; Banerjee, SK; Borkar, RM; Das, AP; Kanwal, A; Pulimamidi, SS; Raju, B; Srinivas, R1
Helvacı, B; Helvacı, Ö1
Gerwin, LE; Leslie, BR; Taylor, SI1
Bellion, P; Niederberger, KE; Tennant, DR1
Fralick, M; Kesselheim, AS1
Chung, SJ; Hwang, JY; Jang, TS; Kim, JK; Kim, KH; Seo, SO; So, HM; Yoon, SY; Yu, JS1
Accili, D; Ishida, E; Kim-Muller, JY1
Akamine, T; Kawanami, D; Matoba, K; Nagai, Y; Sango, K; Takeda, Y; Utsunomiya, K; Yokota, T1
Artner, I; Axelsson, AS; Bagge, A; Costa, IG; Derry, JMJ; Eliasson, L; Fex, M; Gusmao, EG; Hänzelmann, S; Johnson, JD; Mahdi, T; Mecham, B; Millstein, J; Mulder, H; Nenonen, HA; Reinbothe, TM; Rosengren, AH; Salö, S; Shu, L; Singh, T; Spégel, P; Szabat, M; Tang, Y; Wang, J; Wendt, A; Wollheim, CB; Yang, X; Zhang, B; Zhang, E1
Esatbeyoglu, T; Fischer, A; Lüersen, K; Rimbach, G; Schloesser, A; Schultheiß, G; Vollert, H1
Jörgens, V1
Ghezzi, C; Loo, DDF; Wright, EM1
Rieg, T; Vallon, V1
Cegieła, U; Folwarczna, J; Janas, A; Londzin, P; Pytlik, M; Siudak, S; Waligóra, A1
Fang, M; Gao, Z; Hu, H; Jia, L; Li, Q; Wang, A; Wang, Z; Yi, K; Zhang, X1
Bagler, G; Bhushan, S; Randhawa, V; Sharma, P1
Araki, E; Goto, R; Igata, M; Kawasaki, S; Kawashima, J; Kitano, S; Kondo, T; Matsumura, T; Matsuyama, R; Miyagawa, K; Motoshima, H; Ono, K1
Mauricio, D1
Cai, W; Jiang, L; Liu, W; Liu, Y; Xie, Y; Zhao, G1
Kakimoto, K; Katsuda, Y; Kemmochi, Y; Kume, S; Mera, Y; Motohashi, Y; Ohta, T; Sasase, T; Tadaki, H; Toyoda, K1
Despa, F; Despa, S; Lambert, R; Margulies, KB; Peng, X; Srodulski, S1
Henry, RR; Mudaliar, S; Polidori, D; Zambrowicz, B1
Choi, CI1
Gao, Z; Hu, H; Li, X; Liu, G; Mei, X; Wang, Z; Zhang, X; Zou, L1
Thomson, SC; Vallon, V1
Ito, J; Mashiko, S; Moriya, R; Seo, T; Shirakura, T1
Del Prato, S1
Cano Megías, M; González Albarrán, O; Pérez López, G1
Dubrey, SW; Hardman, TC; Rutherford, P; Wierzbicki, AS1
Hayashizaki, Y; Imamura, M; Kihara, R; Kobayashi, Y; Kurosaki, E; Noda, A; Qun, L; Sasamata, M; Shibasaki, M; Tahara, A; Takasu, T; Tomiyama, H; Yamajuku, D; Yokono, M1
Simonyi, G1
Sheridan, C1
Bosch, RR; Hermus, AR; Janssen, SW; Martens J M, G; Olthaar, A; Span, PN; Sweep, CC; van Emst-de Vries, SE; Willems, PH1
Gavrilova, O; Jou, W; Kim, H; LeRoith, D; Setser, J; Sun, H; Yakar, S; Zhang, Y; Zhao, H1
Berthault, MF; Cerasi, E; Donath, MY; Kaiser, N; Kargar, C; Ktorza, A; Oprescu, AI; Uçkaya, G; Yuli, M1
Bronson, SK; Gardner, TW; Hong, EG; Jun, JY; Jung, DY; Kim, JH; Kim, JK; Ko, HJ; Ma, Z; Sumner, AD; Vary, TC; Zhang, Z1
Allen, LE; Caro, JF; Colberg, J; Considine, RV; Lanza-Jacoby, S; Morales, LM; Nyce, MR; Serrano, J; Triester, S1
Mizuno, A; Noma, Y; Sano, T; Shima, K; Zhu, M1
Efendić, S; Kawano, Y; Krook, A; Roth, RA; Song, XM; Wallberg-Henriksson, H; Zierath, JR1
Buongiorno, A; Giaccari, A; Maroccia, E; Morviducci, L; Pastore, L; Sbraccia, P; Tamburrano, G; Zorretta, D1
Kuwajima, M; Murakami, T; Ogino, T; Shima, K; Zhu, M1
Fujimiya, M; Fujita, Y; Hidaka, H; Kashiwagi, A; Kikkawa, R; Kojima, H1
Efendic, S; Kawano, Y; Krook, A; Roth, RA; Ryder, JW; Song, XM; Wallberg-Henriksson, H; Zierath, JR1
Federici, M; Giaccari, A; Giovannone, B; Hribal, ML; Lauro, D; Lauro, R; Morviducci, L; Pastore, L; Sesti, G; Tamburrano, G1
Efendic, S; Hong-Lie, C; Khan, A; Ling, ZC; Ostenson, CG1
Dong, J; Fillmore, JJ; Kahn, BB; Kahn, CR; Kim, JK; Kotani, K; Peroni, OD; Perret, P; Shulman, GI; Zisman, A; Zong, H1
Bailbé, D; Blondel, O; Portha, B; Serradas, P1
Bailbe, D; Blondel, O; Portha, B1
Lauglin, MR; Rossetti, L1

Reviews

15 review(s) available for phlorhizin and Diabetes Mellitus, Adult-Onset

ArticleYear
Development of the renal glucose reabsorption inhibitors: a new mechanism for the pharmacotherapy of diabetes mellitus type 2.
    Journal of medicinal chemistry, 2009, Apr-09, Volume: 52, Issue:7

    Topics: Animals; Clinical Trials as Topic; Diabetes Mellitus, Type 2; Drug Evaluation, Preclinical; Glucose; Glucosides; Humans; Hypoglycemic Agents; Kidney; Sodium-Glucose Transporter 2 Inhibitors

2009
Synthetic strategy and SAR studies of C-glucoside heteroaryls as SGLT2 inhibitor: A review.
    European journal of medicinal chemistry, 2019, Dec-15, Volume: 184

    Topics: Animals; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Glucosides; Humans; Hypoglycemic Agents; Molecular Structure; Sodium-Glucose Transporter 2; Sodium-Glucose Transporter 2 Inhibitors; Structure-Activity Relationship

2019
Sodium/glucose cotransporter 2 and renoprotection: From the perspective of energy regulation and water conservation.
    Journal of pharmacological sciences, 2021, Volume: 147, Issue:3

    Topics: Administration, Oral; Body Water; Diabetes Mellitus, Type 2; Diuresis; Energy Metabolism; Glucose; Humans; Hypoglycemic Agents; Kidney; Kidney Tubules, Proximal; Malus; Osmosis; Phlorhizin; Phytotherapy; Sodium; Sodium-Glucose Transporter 2

2021
SGLT2 Inhibitors: Physiology and Pharmacology.
    Kidney360, 2021, 12-30, Volume: 2, Issue:12

    Topics: Diabetes Mellitus, Type 2; Glucose; Humans; Phlorhizin; Sodium-Glucose Transport Proteins; Sodium-Glucose Transporter 2 Inhibitors

2021
SGLT2 Inhibitors as a Therapeutic Option for Diabetic Nephropathy.
    International journal of molecular sciences, 2017, May-18, Volume: 18, Issue:5

    Topics: Animals; Cardiovascular Diseases; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Humans; Phlorhizin; Randomized Controlled Trials as Topic; Sodium-Glucose Transporter 2; Sodium-Glucose Transporter 2 Inhibitors

2017
Physiology of renal glucose handling via SGLT1, SGLT2 and GLUT2.
    Diabetologia, 2018, Volume: 61, Issue:10

    Topics: Animals; Blood Glucose; Diabetes Mellitus, Type 2; Drug Design; Glucose; Glucose Transporter Type 2; Glycosuria; HEK293 Cells; Homeostasis; Humans; Hypoglycemic Agents; Kidney; Kidney Tubules; Kidney Tubules, Proximal; Mice; Mice, Knockout; Phlorhizin; Sodium-Glucose Transporter 1; Sodium-Glucose Transporter 2; Sodium-Glucose Transporter 2 Inhibitors

2018
Development of SGLT1 and SGLT2 inhibitors.
    Diabetologia, 2018, Volume: 61, Issue:10

    Topics: Animals; Blood Glucose; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diabetic Ketoacidosis; Disease Models, Animal; Drug Design; Glucose; Humans; Intestinal Mucosa; Kidney; Mice; Mutation; Phlorhizin; Sodium-Glucose Transporter 1; Sodium-Glucose Transporter 2; Sodium-Glucose Transporter 2 Inhibitors

2018
[Sodium-glucose co-transporter-2 inhibitors: from the bark of apple trees and familial renal glycosuria to the treatment of type 2 diabetes mellitus].
    Medicina clinica, 2013, Volume: 141 Suppl 2

    Topics: Adsorption; Animals; Benzhydryl Compounds; Biological Transport, Active; Canagliflozin; Clinical Trials, Phase III as Topic; Diabetes Mellitus, Type 2; Drugs, Investigational; Glucose; Glucosides; Glycosides; Glycosuria; Glycosuria, Renal; Humans; Hypoglycemic Agents; Kidney Tubules, Proximal; Malus; Phlorhizin; Phytotherapy; Plant Bark; Rats; Sodium-Glucose Transporter 2; Sodium-Glucose Transporter 2 Inhibitors; Thiophenes; Treatment Outcome

2013
Design of SGLT2 Inhibitors for the Treatment of Type 2 Diabetes: A History Driven by Biology to Chemistry.
    Medicinal chemistry (Shariqah (United Arab Emirates)), 2015, Volume: 11, Issue:4

    Topics: Benzhydryl Compounds; Diabetes Mellitus, Type 2; Drug Design; Drug Discovery; Glucosides; Glycosides; History, 20th Century; History, 21st Century; Humans; Hypoglycemic Agents; Monosaccharides; Phlorhizin; Sodium-Glucose Transporter 2; Sodium-Glucose Transporter 2 Inhibitors; Structure-Activity Relationship

2015
Sodium-Glucose Cotransporter Inhibitors: Effects on Renal and Intestinal Glucose Transport: From Bench to Bedside.
    Diabetes care, 2015, Volume: 38, Issue:12

    Topics: Animals; Biological Transport; Diabetes Mellitus, Type 2; Glucose; Glycosuria; Humans; Hypoglycemic Agents; Insulin Resistance; Intestinal Mucosa; Kidney; Phlorhizin; Renal Elimination; Sodium-Glucose Transport Proteins; Sodium-Glucose Transporter 2; Sodium-Glucose Transporter 2 Inhibitors

2015
Sodium-Glucose Cotransporter 2 (SGLT2) Inhibitors from Natural Products: Discovery of Next-Generation Antihyperglycemic Agents.
    Molecules (Basel, Switzerland), 2016, Aug-27, Volume: 21, Issue:9

    Topics: Animals; Diabetes Mellitus, Type 2; Glucose; Herbal Medicine; Humans; Hypoglycemic Agents; Phlorhizin; Phytotherapy; Sodium-Glucose Transporter 2; Sodium-Glucose Transporter 2 Inhibitors

2016
Targeting renal glucose reabsorption to treat hyperglycaemia: the pleiotropic effects of SGLT2 inhibition.
    Diabetologia, 2017, Volume: 60, Issue:2

    Topics: Diabetes Mellitus, Type 2; Glucose; Humans; Hyperglycemia; Insulin Resistance; Kidney; Phlorhizin; Sodium-Glucose Transporter 2; Sodium-Glucose Transporter 2 Inhibitors

2017
[Sodium-glucose cotransporter type 2 inhibitors (SGLT2): from familial renal glucosuria to the treatment of type 2 diabetes mellitus].
    Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia, 2010, Volume: 30, Issue:6

    Topics: Absorption; Animals; Benzhydryl Compounds; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Dogs; Double-Blind Method; Gluconeogenesis; Glucose; Glucosides; Glycosuria, Renal; Homeostasis; Humans; Hypoglycemic Agents; Kidney; Kidney Tubules, Proximal; Mice; Phlorhizin; Randomized Controlled Trials as Topic; Sodium-Glucose Transporter 1; Sodium-Glucose Transporter 2; Sodium-Glucose Transporter 2 Inhibitors

2010
Sodium-glucose co-transporter 2 inhibitors: from apple tree to 'Sweet Pee'.
    Current pharmaceutical design, 2010, Volume: 16, Issue:34

    Topics: Blood Glucose; Diabetes Mellitus, Type 2; Humans; Phlorhizin; Sodium-Glucose Transporter 2; Sodium-Glucose Transporter 2 Inhibitors; Subcellular Fractions

2010
[New possibility in the oral glucose lowering treatment of type 2 diabetes mellitus: sodium-glucose co-transporter-2 inhibitors].
    Orvosi hetilap, 2012, May-06, Volume: 153, Issue:18

    Topics: Administration, Oral; Benzhydryl Compounds; Blood Glucose; Canagliflozin; Diabetes Mellitus, Type 2; Glucosides; Humans; Hypoglycemic Agents; Phlorhizin; Sodium-Glucose Transporter 2 Inhibitors; Thiophenes

2012

Other Studies

51 other study(ies) available for phlorhizin and Diabetes Mellitus, Adult-Onset

ArticleYear
Discovery of dapagliflozin: a potent, selective renal sodium-dependent glucose cotransporter 2 (SGLT2) inhibitor for the treatment of type 2 diabetes.
    Journal of medicinal chemistry, 2008, Mar-13, Volume: 51, Issue:5

    Topics: Administration, Oral; Animals; Benzhydryl Compounds; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Glucosides; Humans; Hypoglycemic Agents; Kidney; Rats; Sodium-Glucose Transporter 2; Sodium-Glucose Transporter 2 Inhibitors; Stereoisomerism

2008
Novel L-xylose derivatives as selective sodium-dependent glucose cotransporter 2 (SGLT2) inhibitors for the treatment of type 2 diabetes.
    Journal of medicinal chemistry, 2009, Oct-22, Volume: 52, Issue:20

    Topics: Animals; Diabetes Mellitus, Type 2; Drug Discovery; Glucose; Humans; Mice; Sodium-Glucose Transporter 2 Inhibitors; Substrate Specificity; Xylose

2009
(1S)-1,5-anhydro-1-[5-(4-ethoxybenzyl)-2-methoxy-4-methylphenyl]-1-thio-D-glucitol (TS-071) is a potent, selective sodium-dependent glucose cotransporter 2 (SGLT2) inhibitor for type 2 diabetes treatment.
    Journal of medicinal chemistry, 2010, Apr-22, Volume: 53, Issue:8

    Topics: Animals; Biological Availability; Blood Proteins; Caco-2 Cells; Cell Membrane Permeability; CHO Cells; Cricetinae; Cricetulus; Diabetes Mellitus, Type 2; Dogs; Hepatocytes; Humans; Hypoglycemic Agents; In Vitro Techniques; Microsomes, Liver; Protein Binding; Rats; Rats, Zucker; Sodium-Glucose Transporter 2; Sodium-Glucose Transporter 2 Inhibitors; Sorbitol; Structure-Activity Relationship; Tissue Distribution

2010
Discovery of novel N-β-D-xylosylindole derivatives as sodium-dependent glucose cotransporter 2 (SGLT2) inhibitors for the management of hyperglycemia in diabetes.
    Journal of medicinal chemistry, 2011, Jan-13, Volume: 54, Issue:1

    Topics: Animals; CHO Cells; Cricetinae; Cricetulus; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Glucose; Glucosides; Humans; Hyperglycemia; Hypoglycemic Agents; Indoles; Male; Mice; Mice, Inbred ICR; Rats; Rats, Sprague-Dawley; Sodium-Glucose Transporter 2 Inhibitors; Structure-Activity Relationship; Xylose

2011
5a-Carba-β-D-glucopyranose derivatives as novel sodium-dependent glucose cotransporter 2 (SGLT2) inhibitors for the treatment of type 2 diabetes.
    Bioorganic & medicinal chemistry, 2011, Sep-15, Volume: 19, Issue:18

    Topics: Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Glucose; Male; Mice; Mice, Obese; Molecular Conformation; Molecular Sequence Data; Sodium-Glucose Transporter 2; Sodium-Glucose Transporter 2 Inhibitors; Stereoisomerism; Structure-Activity Relationship; Tissue Distribution

2011
C-Aryl 5a-carba-β-d-glucopyranosides as novel sodium glucose cotransporter 2 (SGLT2) inhibitors for the treatment of type 2 diabetes.
    Bioorganic & medicinal chemistry, 2012, Jul-01, Volume: 20, Issue:13

    Topics: Administration, Oral; Animals; Area Under Curve; Blood Glucose; Cyclohexanols; Diabetes Mellitus, Type 2; Glucose; Hypoglycemic Agents; Mice; Mice, Obese; Sodium-Glucose Transporter 2; Sodium-Glucose Transporter 2 Inhibitors; Structure-Activity Relationship

2012
Discovery of tofogliflozin, a novel C-arylglucoside with an O-spiroketal ring system, as a highly selective sodium glucose cotransporter 2 (SGLT2) inhibitor for the treatment of type 2 diabetes.
    Journal of medicinal chemistry, 2012, Sep-13, Volume: 55, Issue:17

    Topics: Animals; Benzhydryl Compounds; Diabetes Mellitus, Type 2; Glucosides; Humans; Macaca fascicularis; Magnetic Resonance Spectroscopy; Mice; Mice, Inbred ICR; Models, Molecular; Sodium-Glucose Transporter 2; Sodium-Glucose Transporter 2 Inhibitors; Spectrometry, Mass, Electrospray Ionization

2012
N-Indolylglycosides bearing modifications at the glucose C6-position as sodium-dependent glucose co-transporter 2 inhibitors.
    Bioorganic & medicinal chemistry, 2016, 05-15, Volume: 24, Issue:10

    Topics: Animals; CHO Cells; Cricetulus; Diabetes Mellitus, Type 2; Glucose; Glycosides; Humans; Hypoglycemic Agents; Rats, Sprague-Dawley; Small Molecule Libraries; Sodium-Glucose Transporter 2; Sodium-Glucose Transporter 2 Inhibitors

2016
Targeting Type 2 Diabetes with C-Glucosyl Dihydrochalcones as Selective Sodium Glucose Co-Transporter 2 (SGLT2) Inhibitors: Synthesis and Biological Evaluation.
    Journal of medicinal chemistry, 2017, 01-26, Volume: 60, Issue:2

    Topics: Chalcones; Diabetes Mellitus, Type 2; Glucosides; HEK293 Cells; Humans; Membranes, Artificial; Molecular Docking Simulation; Phosphatidylcholines; Sodium-Glucose Transporter 1; Sodium-Glucose Transporter 2; Sodium-Glucose Transporter 2 Inhibitors

2017
Ameliorative potential of phloridzin in type 2 diabetes-induced memory deficits in rats.
    European journal of pharmacology, 2021, Dec-15, Volume: 913

    Topics: Acetylcholine; Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Humans; Male; Maze Learning; Memory; Memory Disorders; Molecular Docking Simulation; Nerve Growth Factors; Oxidative Stress; Phlorhizin; Rats; Receptor, Muscarinic M1; Scopolamine; Streptozocin; Synaptic Transmission; Up-Regulation

2021
[From the discovery of phlorizin (a Belgian story) to SGLT2 inhibitors].
    Revue medicale de Liege, 2022, Volume: 77, Issue:3

    Topics: Belgium; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Phlorhizin; Sodium-Glucose Transporter 2; Sodium-Glucose Transporter 2 Inhibitors

2022
Docosahexaenoic Acid Ester of Phloridzin Reduces Inflammation and Insulin Resistance
    Current pharmaceutical design, 2022, Volume: 28, Issue:22

    Topics: AMP-Activated Protein Kinases; Cell Line; Diabetes Mellitus, Type 2; Docosahexaenoic Acids; Esters; Glucose; Humans; Inflammation; Insulin; Insulin Resistance; Muscle Fibers, Skeletal; Palmitic Acid; Phlorhizin

2022
Phloretin and phlorizin mitigates inflammatory stress and alleviate adipose and hepatic insulin resistance by abrogating PPARγ S273-Cdk5 interaction in type 2 diabetic mice.
    Life sciences, 2023, Jun-01, Volume: 322

    Topics: Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Insulin Resistance; Mice; Obesity; Phloretin; Phlorhizin; PPAR gamma

2023
A pharmacokinetic study to correlate the hypoglycemic effect of phlorizin in rats: Identification of metabolites as inhibitors of sodium/glucose cotransporters.
    Journal of mass spectrometry : JMS, 2023, Volume: 58, Issue:8

    Topics: Animals; Chromatography, High Pressure Liquid; Diabetes Mellitus, Type 2; Glucose; Hypoglycemic Agents; Phlorhizin; Rats; Rats, Sprague-Dawley; Sodium; Sodium-Glucose Transporter 2; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry

2023
A Story of Serendipities: From Phlorizin to Gliflozins.
    Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation, 2023, Volume: 21, Issue:Suppl 2

    Topics: Animals; Diabetes Mellitus, Type 2; Dogs; Hypoglycemic Agents; Insulin; Phlorhizin; Sodium-Glucose Transporter 2 Inhibitors

2023
Sodium-Glucose Cotransporter-2 Inhibitors: Lack of a Complete History Delays Diagnosis.
    Annals of internal medicine, 2019, 09-17, Volume: 171, Issue:6

    Topics: Delayed Diagnosis; Diabetes Mellitus, Type 2; Drug Approval; Glycosuria, Renal; History, 19th Century; History, 20th Century; History, 21st Century; Humans; Ketosis; Phlorhizin; Sodium-Glucose Transporter 2 Inhibitors; United States; United States Food and Drug Administration

2019
Dietary intake of phloridzin from natural occurrence in foods.
    The British journal of nutrition, 2020, 04-28, Volume: 123, Issue:8

    Topics: Diabetes Mellitus, Type 2; Food Analysis; Humans; Models, Biological; Phlorhizin

2020
Using real-world safety data in regulatory approval decisions: Sotagliflozin and the risk of diabetic ketoacidosis.
    Pharmacoepidemiology and drug safety, 2020, Volume: 29, Issue:10

    Topics: Clinical Trials as Topic; Data Collection; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diabetic Ketoacidosis; Drug Approval; Glycosides; Humans; Phlorhizin; Sodium-Glucose Transporter 2 Inhibitors; Treatment Outcome; United States; United States Food and Drug Administration

2020
Phloridzin Acts as an Inhibitor of Protein-Tyrosine Phosphatase MEG2 Relevant to Insulin Resistance.
    Molecules (Basel, Switzerland), 2021, Mar-14, Volume: 26, Issue:6

    Topics: 3T3 Cells; Adipocytes; Animals; Cell Differentiation; Cell Line; Diabetes Mellitus, Type 2; Glucose; Hypoglycemic Agents; Insulin; Insulin Resistance; Mice; Palmitates; Phlorhizin; Phosphorylation; Protein Tyrosine Phosphatases; Protein Tyrosine Phosphatases, Non-Receptor; Signal Transduction

2021
Pair Feeding, but Not Insulin, Phloridzin, or Rosiglitazone Treatment, Curtails Markers of β-Cell Dedifferentiation in
    Diabetes, 2017, Volume: 66, Issue:8

    Topics: Animals; Biomarkers; Blood Glucose; Cell Dedifferentiation; Diabetes Mellitus, Type 2; Disease Models, Animal; Eating; Humans; Hypoglycemic Agents; Insulin; Insulin-Secreting Cells; Mice; Phlorhizin; Rosiglitazone; Thiazolidinediones

2017
Sox5 regulates beta-cell phenotype and is reduced in type 2 diabetes.
    Nature communications, 2017, 06-06, Volume: 8

    Topics: Animals; Calcium; Calcium Channels; Chromatin; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Exocytosis; Female; Gene Expression Regulation; Humans; Insulin; Insulin-Secreting Cells; Islets of Langerhans; Male; Mice; Mice, Inbred C57BL; Oligonucleotide Array Sequence Analysis; Phenotype; Phlorhizin; Rats; RNA, Small Interfering; SOXD Transcription Factors; Valproic Acid

2017
Antidiabetic Properties of an Apple/Kale Extract In Vitro, In Situ, and in Mice Fed a Western-Type Diet.
    Journal of medicinal food, 2017, Volume: 20, Issue:9

    Topics: alpha-Glucosidases; Animals; Blood Glucose; Brassica; Diabetes Mellitus, Type 2; Diet, High-Fat; Female; Flavonoids; Glucose Tolerance Test; Humans; Hypoglycemic Agents; Male; Malus; Mice; Mice, Inbred C57BL; Phlorhizin; Plant Extracts; Sodium-Glucose Transporter 1

2017
The roots of SGLT inhibition: Laurent-Guillaume de Koninck, Jean Servais Stas and Freiherr Josef von Mering.
    Acta diabetologica, 2019, Volume: 56, Issue:1

    Topics: Belgium; Chemistry, Pharmaceutical; Diabetes Mellitus, Type 2; Drug Discovery; Germany; History, 19th Century; History, 20th Century; History, 21st Century; Humans; Insulin; Phlorhizin; Sodium-Glucose Transporter 2 Inhibitors

2019
Phloridzin, an Apple Polyphenol, Exerted Unfavorable Effects on Bone and Muscle in an Experimental Model of Type 2 Diabetes in Rats.
    Nutrients, 2018, Nov-07, Volume: 10, Issue:11

    Topics: Animals; Bone and Bones; Bone Density; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Diet, High-Fat; Female; Hyperglycemia; Hypoglycemic Agents; Malus; Muscle, Skeletal; Phloretin; Phlorhizin; Polyphenols; Rats; Rats, Wistar

2018
Comparative oral and intravenous pharmacokinetics of phlorizin in rats having type 2 diabetes and in normal rats based on phase II metabolism.
    Food & function, 2019, Mar-20, Volume: 10, Issue:3

    Topics: Administration, Oral; Animals; Area Under Curve; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Half-Life; Injections, Intravenous; Male; Molecular Structure; Phlorhizin; Random Allocation; Rats; Rats, Wistar; Research Design; Specific Pathogen-Free Organisms

2019
Identification of key nodes of type 2 diabetes mellitus protein interactome and study of their interactions with phloridzin.
    Omics : a journal of integrative biology, 2013, Volume: 17, Issue:6

    Topics: Binding Sites; Computational Biology; Diabetes Mellitus, Type 2; E1A-Associated p300 Protein; Gene Expression Profiling; Genetic Association Studies; Humans; Mitogen-Activated Protein Kinase 1; Molecular Conformation; Molecular Docking Simulation; Molecular Dynamics Simulation; Molecular Sequence Annotation; Phlorhizin; Protein Binding; Protein Interaction Domains and Motifs; Protein Interaction Mapping; Protein Interaction Maps; Proteome; Smad2 Protein

2013
Effects of combination therapy with vildagliptin and valsartan in a mouse model of type 2 diabetes.
    Cardiovascular diabetology, 2013, Nov-04, Volume: 12

    Topics: Adamantane; Adiponectin; Angiotensin II Type 1 Receptor Blockers; Animals; Blood Glucose; Cytokines; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Dipeptidyl-Peptidase IV Inhibitors; Disease Models, Animal; Drug Therapy, Combination; Fatty Liver; Homeodomain Proteins; Inflammation; Insulin; Insulin Resistance; Insulin Secretion; Insulin-Secreting Cells; Mice; Mice, Inbred C57BL; Nitriles; Phlorhizin; Pyrrolidines; Tetrazoles; Trans-Activators; Valine; Valsartan; Vildagliptin

2013
Contribution of hyperglycemia on diabetic complications in obese type 2 diabetic SDT fatty rats: effects of SGLT inhibitor phlorizin.
    Experimental animals, 2015, Volume: 64, Issue:2

    Topics: Albuminuria; Animals; Blood Glucose; Diabetes Complications; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Diabetic Neuropathies; Diabetic Retinopathy; Disease Models, Animal; Female; Hyperglycemia; Kidney Tubules; Phlorhizin; Rats, Inbred Strains; Rats, Sprague-Dawley; Sodium-Glucose Transport Proteins

2015
Intracellular Na+ Concentration ([Na+]i) Is Elevated in Diabetic Hearts Due to Enhanced Na+-Glucose Cotransport.
    Journal of the American Heart Association, 2015, Aug-27, Volume: 4, Issue:9

    Topics: Aged; Animals; Diabetes Mellitus, Type 2; Diabetic Cardiomyopathies; Disease Models, Animal; Female; Heart Failure; Humans; Male; Middle Aged; Myocardium; Myocytes, Cardiac; Phlorhizin; Rats, Sprague-Dawley; Sodium; Sodium-Glucose Transporter 1; Time Factors; Up-Regulation

2015
Insulin Sensitivity-Enhancing Activity of Phlorizin Is Associated with Lipopolysaccharide Decrease and Gut Microbiota Changes in Obese and Type 2 Diabetes (db/db) Mice.
    Journal of agricultural and food chemistry, 2016, Oct-12, Volume: 64, Issue:40

    Topics: Animals; Body Weight; Diabetes Mellitus, Type 2; Energy Intake; Fatty Acids, Volatile; Gastrointestinal Microbiome; Hypoglycemic Agents; Insulin Resistance; Lipopolysaccharides; Male; Mice, Mutant Strains; Mice, Obese; Phlorhizin

2016
Activation of sodium-glucose cotransporter 1 ameliorates hyperglycemia by mediating incretin secretion in mice.
    American journal of physiology. Endocrinology and metabolism, 2009, Volume: 297, Issue:6

    Topics: Animals; Blood Glucose; Diabetes Mellitus, Type 2; Gastric Inhibitory Polypeptide; Glucagon-Like Peptide 1; Glucose; Glucose Tolerance Test; Hyperglycemia; Intestine, Large; Male; Methylglucosides; Mice; Mice, Inbred C57BL; Phlorhizin; Random Allocation; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sodium-Glucose Transporter 1

2009
Role of glucotoxicity and lipotoxicity in the pathophysiology of Type 2 diabetes mellitus and emerging treatment strategies.
    Diabetic medicine : a journal of the British Diabetic Association, 2009, Volume: 26, Issue:12

    Topics: Animals; B-Lymphocytes; Diabetes Mellitus, Type 2; Disease Progression; Genetic Predisposition to Disease; Glucose; Humans; Lipid Metabolism; Phlorhizin; Rats; RNA, Messenger; TCF Transcription Factors; Thiazolidinediones; Transcription Factor 7-Like 2 Protein

2009
Pharmacological profile of ipragliflozin (ASP1941), a novel selective SGLT2 inhibitor, in vitro and in vivo.
    Naunyn-Schmiedeberg's archives of pharmacology, 2012, Volume: 385, Issue:4

    Topics: Animals; Blood Glucose; Carbohydrate Metabolism; CHO Cells; Cricetinae; Cricetulus; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Gastrointestinal Tract; Glucosides; Humans; Hypoglycemic Agents; Insulin; Male; Mice; Mice, Inbred ICR; Phlorhizin; Rats; Rats, Sprague-Dawley; Sodium-Glucose Transporter 1; Sodium-Glucose Transporter 2 Inhibitors; Thiophenes

2012
SGLT2 inhibitors race to enter type-2 diabetes market.
    Nature biotechnology, 2012, Volume: 30, Issue:10

    Topics: Animals; Clinical Trials as Topic; Diabetes Mellitus, Type 2; Drug Approval; Drug Discovery; Humans; Hypoglycemic Agents; Insulin-Secreting Cells; Marketing; Phlorhizin; Sodium-Glucose Transporter 1; Sodium-Glucose Transporter 2; Sodium-Glucose Transporter 2 Inhibitors; United States; United States Food and Drug Administration

2012
Exploring levels of hexosamine biosynthesis pathway intermediates and protein kinase C isoforms in muscle and fat tissue of Zucker Diabetic Fatty rats.
    Endocrine, 2003, Volume: 20, Issue:3

    Topics: Adipose Tissue; Aging; Animals; Blood Glucose; Blotting, Western; Diabetes Mellitus, Type 2; Hexosamines; Insulin; Isoenzymes; Male; Muscle, Skeletal; Nucleotides; Phlorhizin; Protein Kinase C; Rats; Rats, Zucker; Uridine Diphosphate N-Acetylgalactosamine; Uridine Diphosphate N-Acetylglucosamine

2003
Phloridzin improves hyperglycemia but not hepatic insulin resistance in a transgenic mouse model of type 2 diabetes.
    Diabetes, 2004, Volume: 53, Issue:11

    Topics: Adipose Tissue; Animals; Blood Glucose; Body Composition; Diabetes Mellitus, Type 2; Disease Models, Animal; Energy Intake; Hyperglycemia; Insulin Resistance; Liver; Male; Mice; Mice, Transgenic; Phlorhizin

2004
Dynamic changes in {beta}-cell mass and pancreatic insulin during the evolution of nutrition-dependent diabetes in psammomys obesus: impact of glycemic control.
    Diabetes, 2005, Volume: 54, Issue:1

    Topics: Animals; Diabetes Mellitus, Type 2; Diet; Diet, Diabetic; Energy Metabolism; Gerbillinae; Insulin; Insulin Secretion; Islets of Langerhans; Kinetics; Phlorhizin; Time Factors

2005
Nonobese, insulin-deficient Ins2Akita mice develop type 2 diabetes phenotypes including insulin resistance and cardiac remodeling.
    American journal of physiology. Endocrinology and metabolism, 2007, Volume: 293, Issue:6

    Topics: Adipose Tissue; Animals; Blood Glucose; Diabetes Mellitus, Type 2; Energy Metabolism; Fatty Acids; Glucose; Glucose Clamp Technique; Glucose Transporter Type 4; Hyperglycemia; Hypertrophy, Left Ventricular; Insulin; Insulin Resistance; Liver; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Muscle, Skeletal; Oxygen Consumption; Phlorhizin; Protein Kinase C-epsilon; Triglycerides; Ventricular Remodeling

2007
Protein kinase C is increased in the liver of humans and rats with non-insulin-dependent diabetes mellitus: an alteration not due to hyperglycemia.
    The Journal of clinical investigation, 1995, Volume: 95, Issue:6

    Topics: Adult; Animals; Diabetes Mellitus, Type 2; Diglycerides; Female; Humans; Insulin; Insulin Resistance; Isoenzymes; Liver; Male; Middle Aged; Obesity; Phlorhizin; Protein Kinase C; Rats; Receptor, Insulin

1995
Poor capacity for proliferation of pancreatic beta-cells in Otsuka-Long-Evans-Tokushima Fatty rat: a model of spontaneous NIDDM.
    Diabetes, 1996, Volume: 45, Issue:7

    Topics: Animals; Blood Glucose; Body Weight; Cell Division; Diabetes Mellitus; Diabetes Mellitus, Type 2; Female; Humans; Hyperglycemia; Islets of Langerhans; Male; Niacinamide; Obesity; Pancreatectomy; Phlorhizin; Rats; Rats, Mutant Strains

1996
Improved glucose tolerance restores insulin-stimulated Akt kinase activity and glucose transport in skeletal muscle from diabetic Goto-Kakizaki rats.
    Diabetes, 1997, Volume: 46, Issue:12

    Topics: Animals; Biological Transport; Blood Glucose; Diabetes Mellitus, Type 2; Glucose; Glucose Tolerance Test; Insulin; Insulin Resistance; Male; Muscle, Skeletal; Phlorhizin; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Rats; Rats, Mutant Strains

1997
Relative contribution of glycogenolysis and gluconeogenesis to hepatic glucose production in control and diabetic rats. A re-examination in the presence of euglycaemia.
    Diabetologia, 1998, Volume: 41, Issue:3

    Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Disease Models, Animal; Fatty Acids, Nonesterified; Gluconeogenesis; Glucose; Glucose Clamp Technique; Glucose-6-Phosphate; Hyperglycemia; Hyperinsulinism; Hypoglycemic Agents; Insulin; Liver; Liver Glycogen; Male; Phlorhizin; Rats; Rats, Sprague-Dawley; Reference Values; Sodium Chloride

1998
Effect of partial pancreatectomy on beta-cell mass in the remnant pancreas of Wistar fatty rats.
    The journal of medical investigation : JMI, 1998, Volume: 45, Issue:1-4

    Topics: Animals; Blood Glucose; Cell Division; Diabetes Mellitus; Diabetes Mellitus, Type 2; Disease Models, Animal; Genotype; Hyperglycemia; Insulin; Insulin Resistance; Islets of Langerhans; Male; Niacinamide; Obesity; Pancreatectomy; Phenotype; Phlorhizin; Rats; Rats, Inbred WKY; Rats, Mutant Strains; Rats, Wistar; Rats, Zucker

1998
Increased intestinal glucose absorption and postprandial hyperglycaemia at the early step of glucose intolerance in Otsuka Long-Evans Tokushima Fatty rats.
    Diabetologia, 1998, Volume: 41, Issue:12

    Topics: Animals; Diabetes Mellitus; Diabetes Mellitus, Type 2; Food; Gene Expression; Glucose; Glucose Intolerance; Glucose Tolerance Test; Hyperglycemia; Insulin Resistance; Intestinal Absorption; Intestines; Male; Monosaccharide Transport Proteins; Obesity; Phlorhizin; Rats; Rats, Long-Evans; Xylose

1998
Muscle fiber type-specific defects in insulin signal transduction to glucose transport in diabetic GK rats.
    Diabetes, 1999, Volume: 48, Issue:3

    Topics: 3-O-Methylglucose; Animals; Biological Transport; Body Weight; Diabetes Mellitus, Type 2; Gene Expression Regulation; Glucose; Glucose Transporter Type 4; Glycogen Synthase; Insulin; Insulin Receptor Substrate Proteins; Monosaccharide Transport Proteins; Muscle Fibers, Skeletal; Muscle Proteins; Muscle, Skeletal; Phlorhizin; Phosphatidylinositol 3-Kinases; Phosphoproteins; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Rats; Rats, Inbred Strains; Rats, Wistar; Signal Transduction; Species Specificity

1999
Evidence for glucose/hexosamine in vivo regulation of insulin/IGF-I hybrid receptor assembly.
    Diabetes, 1999, Volume: 48, Issue:12

    Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Glucosamine; Insulin; Insulin-Like Growth Factor I; Kinetics; Male; Muscle, Skeletal; Phlorhizin; Protein Multimerization; Rats; Rats, Sprague-Dawley; Receptor, IGF Type 1; Receptor, Insulin; Reference Values

1999
Hyperglycemia contributes to impaired insulin response in GK rat islets.
    Diabetes, 2001, Volume: 50 Suppl 1

    Topics: Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Glucose; Glucose-6-Phosphatase; Hyperglycemia; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Male; Oxidation-Reduction; Phlorhizin; Rats; Rats, Wistar

2001
Glucose toxicity and the development of diabetes in mice with muscle-specific inactivation of GLUT4.
    The Journal of clinical investigation, 2001, Volume: 108, Issue:1

    Topics: Adipose Tissue; Age of Onset; Animals; Depression, Chemical; Diabetes Mellitus, Type 2; Disease Models, Animal; Glucose; Glucose Transporter Type 4; Hyperglycemia; Insulin; Insulin Infusion Systems; Insulin Resistance; Kidney Tubules; Liver; Male; Mice; Mice, Knockout; Monosaccharide Transport Proteins; Muscle Proteins; Muscle, Skeletal; Phlorhizin; Prediabetic State; Protein Transport

2001
Abnormal B-cell function in rats with non-insulin-dependent diabetes induced by neonatal streptozotocin: effect of in vivo insulin, phlorizin, or vanadate treatments.
    Pancreas, 1991, Volume: 6, Issue:1

    Topics: Animals; Arginine; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Glucose; In Vitro Techniques; Insulin; Insulin Secretion; Male; Pancreas; Phlorhizin; Rats; Rats, Inbred Strains; Vanadates

1991
Insulin resistance in rats with non-insulin-dependent diabetes induced by neonatal (5 days) streptozotocin: evidence for reversal following phlorizin treatment.
    Metabolism: clinical and experimental, 1990, Volume: 39, Issue:8

    Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Glucose Clamp Technique; Glucose Tolerance Test; Insulin; Insulin Resistance; Insulin Secretion; Kinetics; Phlorhizin; Rats; Rats, Inbred Strains; Reference Values

1990
Correction of chronic hyperglycemia with vanadate, but not with phlorizin, normalizes in vivo glycogen repletion and in vitro glycogen synthase activity in diabetic skeletal muscle.
    The Journal of clinical investigation, 1989, Volume: 84, Issue:3

    Topics: Animals; Chronic Disease; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Glucose Clamp Technique; Glycogen; Glycogen Synthase; Hyperglycemia; Insulin; Liver; Male; Muscles; Phlorhizin; Rats; Rats, Inbred Strains; Vanadates

1989