phlorhizin has been researched along with Alloxan Diabetes in 124 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 36 (29.03) | 18.7374 |
1990's | 38 (30.65) | 18.2507 |
2000's | 19 (15.32) | 29.6817 |
2010's | 27 (21.77) | 24.3611 |
2020's | 4 (3.23) | 2.80 |
Authors | Studies |
---|---|
Biller, SA; Deshpande, PP; Discenza, L; Ellsworth, BA; Flint, OP; Girotra, RN; Hagan, DL; Han, S; Humphreys, WG; Janovitz, EB; Khanna, A; McCann, PJ; Meng, W; Morgan, N; Morrison, EP; Nirschl, AA; Obermeier, MT; Patel, M; Pullockaran, A; Robertson, JG; Sher, PM; Taylor, JR; Wang, A; Washburn, WN; Wetterau, JR; Whaley, JM; Wu, G; Zahler, R | 1 |
Chang, CC; Chao, YS; Chen, CT; Chiu, CH; Chu, KF; Hsiao, WC; Hsieh, CJ; Hsieh, TC; Huang, CY; Hung, MS; Lee, JC; Liu, YW; Song, JS; Tsai, CH; Wang, MH; Wu, SH; Yao, CH; Yeh, TK; Yuan, MC | 1 |
Hagita, H; Higuchi, T; Ikeda, S; Kato, M; Kobayashi, T; Matsuoka, H; Morikawa, K; Murakata, M; Nishimoto, M; Ohmori, M; Ohtake, Y; Ozawa, K; Sato, T; Shimma, N; Suzuki, M; Taka, N; Takano, K; Yamaguchi, K; Yamamoto, K | 1 |
Fujikura, H; Fushimi, N; Isaji, M; Ishikawa-Takemura, Y; Itoh, F; Kamada, N; Kobayashi, S; Miyagi, T; Nakabayashi, T; Ohno, K; Ozawa, T; Shibazaki, T; Shimizu, K; Shiohara, H; Teranishi, H; Tomae, M; Yonekubo, S | 1 |
Chao, YS; Chen, CT; Hsieh, TC; Huang, CY; Huang, YC; Huang, YL; Lee, JC; Song, JS; Wang, MH; Wu, SH; Yao, CH; Yeh, TK; Yuan, MC | 1 |
Badwaik, HR; Kamdi, SP; Nakhate, KT; Raval, A | 1 |
Chhimwal, J; Kumar, S; Padwad, YS; Patial, V; Purohit, R; Singh, R | 1 |
Guo, Y; Mao, X; Ran, Z; Song, Z; Wang, L; Xin, J; Yao, L; Zhang, M; Zhang, Y | 1 |
Jaggi, AS; Kumar, A; Mehta, V; Singh, N | 1 |
Artner, I; Axelsson, AS; Bagge, A; Costa, IG; Derry, JMJ; Eliasson, L; Fex, M; Gusmao, EG; Hänzelmann, S; Johnson, JD; Mahdi, T; Mecham, B; Millstein, J; Mulder, H; Nenonen, HA; Reinbothe, TM; Rosengren, AH; Salö, S; Shu, L; Singh, T; Spégel, P; Szabat, M; Tang, Y; Wang, J; Wendt, A; Wollheim, CB; Yang, X; Zhang, B; Zhang, E | 1 |
Al-Sharea, A; Goldberg, IJ; Hu, Y; Huggins, LA; Murphy, AJ; Nagareddy, PR | 1 |
Cegieła, U; Folwarczna, J; Janas, A; Londzin, P; Pytlik, M; Siudak, S; Waligóra, A | 1 |
Fang, M; Gao, Z; Hu, H; Jia, L; Li, Q; Wang, A; Wang, Z; Yi, K; Zhang, X | 1 |
Baydoun, E; EL-Zein, O; Jaber, H; Kreydiyyeh, SI | 1 |
Cai, Q; Cheng, M; Gao, HQ; Hu, SL; Li, BY; Li, XL; Tan, M; Wang, WD; Yan, G; Yu, F; Zhang, SY | 1 |
Chen, LJ; Cheng, JT; Cheng, MF; Hsu, CT; Wang, MC | 1 |
Brouwers, B; Cauwelier, EJG; Creemers, JWM; Declercq, J; Ectors, N; Lerut, E; Pruniau, VPEG; Schuit, F | 1 |
Araki, E; Goto, R; Igata, M; Kawasaki, S; Kawashima, J; Kitano, S; Kondo, T; Matsumura, T; Matsuyama, R; Miyagawa, K; Motoshima, H; Ono, K | 1 |
Abcouwer, SF; Fort, PE; Gardner, TW; Jefferson, LS; Kimball, SR; Losiewicz, MK; Pennathur, S | 1 |
Hamada, Y; Harada, N; Hayashi, Y; Iida, A; Inagaki, N; Ishikawa, K; Izumoto, T; Miki, T; Ogata, H; Oiso, Y; Ozaki, N; Seino, S; Seino, Y; Suzuki, K; Tsunekawa, S; Uenishi, E | 1 |
Kakimoto, K; Katsuda, Y; Kemmochi, Y; Kume, S; Mera, Y; Motohashi, Y; Ohta, T; Sasase, T; Tadaki, H; Toyoda, K | 1 |
Fasching, A; Franzén, S; O'Neill, J; Palm, F; Patinha, D; Pihl, L | 1 |
Alkaabi, JM; Hamouda, NN; Howarth, FC; Oz, M; Qureshi, MA | 1 |
Campos, RR; Candeia-Medeiros, N; Cavalcante-Araújo, PM; Fátima, LA; Fávaro-Pípi, E; Goulart, LR; Machado, UF; Melo, IS; Oliveira, TL; Rocha, AA; Sabino-Silva, R | 1 |
Guinovart, JJ; Miró-Queralt, M; Planas, JM | 1 |
Chang, CK; Cheng, JT; Cheng, KC; Juang, SW; Kou, DH; Liu, IM; Tong, YC | 1 |
Barac-Nieto, M; Francis, I; Malatiali, S | 1 |
Lin, K; Wang, PH; Yang, JY; Yeh, HY | 1 |
Akimoto, Y; Kobori, M; Masumoto, S; Oike, H | 1 |
Altirriba, J; Barbera, A; Del Zotto, H; Gagliardino, JJ; Gomis, R; Nadal, B; Piquer, S; Sánchez-Pla, A | 1 |
Damiano, F; Giudetti, AM; Gnoni, GV; Mercuri, E; Priore, P; Siculella, L; Stanca, E | 1 |
DERMAN, H | 1 |
Chen, LJ; Cheng, JT; Cheng, MF | 1 |
Cano Megías, M; González Albarrán, O; Pérez López, G | 1 |
Chen, LJ; Cheng, JT; Fong, Y; Shen, KH | 1 |
Hayashizaki, Y; Imamura, M; Kihara, R; Kobayashi, Y; Kurosaki, E; Noda, A; Qun, L; Sasamata, M; Shibasaki, M; Tahara, A; Takasu, T; Tomiyama, H; Yamajuku, D; Yokono, M | 1 |
Arasteh, A; Jahromi, MZ; Kargar, MM; Khajeaian, P; Najafian, M; Nowroznejhad, MJ; Sadeghi, M | 1 |
Chen, LJ; Chen, ZC; Cheng, J; Cheng, KC; Cheng, YZ; Li, Y | 1 |
Arellano, A; Bautista, R; Coronel, I; Escalante, B; Franco, M; Osorio, H; Pacheco, U | 1 |
Brownsey, RW; Marzban, L; McNeill, JH; Rahimian, R | 1 |
Chang, CC; Chen, CL; Chen, HC; Hsieh, MC; Shin, SJ; Wu, CH | 1 |
Abrahani, A; Allard, M; Brownsey, R; Chan, N; Ghosh, S; Kulpa, J; Pulinilkunnil, T; Rodrigues, B; Tang, I; Varghese, J | 1 |
FRANCOIS, R; GUEST, G | 1 |
ALLEGRA, G; NIUTTA, R; PASTORE, G | 1 |
ANGELI, G; CAVAZZUTI, F; FREDDI, S | 1 |
BOL, M; CREUTZFELDT, W; MOENCH, A; RAUH, E; SOELING, HD | 1 |
Eddouks, M; Maghrani, M | 1 |
Boriskie, A; Carmines, PK; Hobbs, JL; Lee, DL; Pollock, DM; Pollock, JS; Sasser, JM | 1 |
Alford, FP; Christopher, MJ; Kemp, BE; McConell, G; Rantzau, C | 1 |
Che, CT; Cheng, CH; Lau, CB; Leung, PS; Li, JM | 1 |
Cheng, JT; Huang, CJ; Liu, IM | 1 |
Chen, HS; Chen, JW; Jia, J; Lai, HC; Lin, HD; Lin, SJ; Mestril, R; Su, HF; Wang, PH; Yang, JY | 1 |
Anhê, GF; Bordin, S; Freitas, HS; Machado, UF; Melo, KF; Okamoto, MM; Oliveira-Souza, M | 1 |
Lopes-Vieira, O; Walker, B; Williamson, DH | 1 |
Deren, JA; Levine, GM; Shiau, YF | 1 |
Hamilton, N; Ianuzzo, CD; Noble, EG | 1 |
Csáky, TZ; Fischer, E | 1 |
Ennis, SR; Johnson, JE; Pautler, EL | 1 |
Kim, JY; Kim, YW; Lee, SK | 1 |
Hirshman, MF; Horton, ES; Napoli, R | 1 |
Debnam, ES; Keable, SJ; Sharp, PA; Smith, MW; Srai, SK; Turvey, A | 1 |
Benedict, M; Hingre, K; McCormick, KL; Mick, GJ | 1 |
Assan, R; Burcelin, R; Girard, J; Granner, DK; Kande, J; Printz, RL | 1 |
Annabi, B; Dimitrakoudis, D; Klip, A; Lavoie, L; Marette, A; van de Werve, G; Vranic, M | 1 |
Burcelin, R; Girard, J; Kande, J; Ricquier, D | 1 |
Brichard, SM; Girard, J; Henquin, JC | 1 |
Barzilai, N; Chen, W; Hu, M; Massillon, D; Rossetti, L | 1 |
Barrera-Hernandez, G; Wanke, IE; Wong, NC | 1 |
Arakawa, K; Hongu, M; Inamasu, M; Matsumoto, M; Oku, A; Saito, K; Tsujihara, K | 1 |
Kim, JK; Wi, JK; Youn, JH | 1 |
Misur, I; Turk, N; Turk, Z | 1 |
Bilinski, D; Carvalho, G; Fisher, SJ; Giacca, A; Lekas, M; Shi, ZQ; Vranic, M | 1 |
Buongiorno, A; Giaccari, A; Maroccia, E; Morviducci, L; Pastore, L; Sbraccia, P; Tamburrano, G; Zorretta, D | 1 |
Cooper, RL; Rastogi, KS; Shi, ZQ; Vranic, M | 1 |
Hara, Y; Hattori, Y; Kabashima, N; Nomura, M; Serino, R; Shibuya, I; Tokunaga, M; Ueta, Y; Yamashita, H | 1 |
Amessou, M; Antoine, PJ; Clot, JP; Desbuquois, B; Descamps, G; Durand, D; Nivet, V | 1 |
Amessou, M; Bortoli, S; Brichard, S; Collinet, M; Desbuquois, B; Girard, J; Liemans, V | 1 |
Bonner-Weir, S; Hasenkamp, W; Ilkova, H; Jonas, JC; Laybutt, R; Patanè, G; Sharma, A; Weir, GC | 1 |
Chinookoswong, N; Shi, ZQ; Wang, JL | 1 |
Dimitrakoudis, D; Klip, A; Marette, A; Rodgers, CD; Shi, Q; Vranic, M | 1 |
Benko, B; Misur, I; Turk, N; Turk, Z | 1 |
Federici, M; Giaccari, A; Giovannone, B; Hribal, ML; Lauro, D; Lauro, R; Morviducci, L; Pastore, L; Sesti, G; Tamburrano, G | 1 |
Blantz, RC; Osswald, H; Richter, K; Thomson, S; Vallon, V | 1 |
Shen, D; Zhang, S; Zhu, M | 1 |
Fridkin, M; Gershonov, E; Goldwaser, I; Sekar, N; Shechter, Y; Sun, Q | 1 |
Cheng, JT; Hsu, CT; Liu, IM | 1 |
Hopfer, U | 1 |
Christlieb, AR; Long, R | 1 |
Dobbs, R; Unger, RH; Valverde, I | 1 |
Alexander, D; Gelato, MC; Marsh, K | 1 |
Dimitrakoudis, D; Klip, A; Vranic, M | 1 |
Dimitrakoudis, D; Klip, A; Ramlal, T; Rastogi, S; Vranic, M | 1 |
Field, MJ; Lawrence, JR; Pollock, CA | 1 |
Cheeseman, CI; Fedorak, RN; Porter, VM; Thomson, AB | 1 |
Cushman, SW; DeFronzo, RA; Kahn, BB; Rossetti, L; Shulman, GI | 1 |
Bailbé, D; Blondel, O; Portha, B; Serradas, P | 1 |
Fujii, Y; Hashida, F; Ishibashi, S; Kaizuka, M; Kurokawa, T; Maruo, J; Sato, E; Yasuda, H | 1 |
Debnam, ES; Ebrahim, HY; Swaine, DJ | 1 |
Bell, GI; DeSautel, SL; Kayano, T; Pessin, JE; Sivitz, WI | 1 |
Andraghetti, G; Cordera, R; DeFronzo, RA; Rossetti, L | 1 |
Bailbe, D; Blondel, O; Portha, B | 1 |
Lauglin, MR; Rossetti, L | 1 |
Fedorak, RN; Field, M; Gershon, MD | 1 |
Byers, M; Gauthier, C; Hetenyi, G; Vranic, M | 1 |
Alpert, HC; Gouvea, WL; Kelley, J; Pardo, V; Vaamonde, CA | 1 |
Imamura, T; Starke, A; Unger, RH | 1 |
Chang, EB; Fedorak, RN; Field, M; Madara, JL | 1 |
Brenner, BM; Harris, RC; Seifter, JL | 1 |
Hosoya, N; Moriuchi, S; Takai, K; Tsuji, Y; Yamada, K | 1 |
DeFronzo, RA; Rossetti, L; Shulman, GI; Zawalich, W | 1 |
Helderman, JH; Imamura, T; Koffler, M; Santeusanio, F | 1 |
Hetenyi, G; Kovacevic, N; Lussier, B; Vranic, M | 1 |
McGiff, JC; Quilley, J | 1 |
DeFronzo, RA; Papachristou, D; Rossetti, L; Shulman, GI; Smith, D | 1 |
Hartenstein, H; Luppa, D; Müller, F | 1 |
Grundy, S; McGarry, JD; Starke, A; Unger, RH | 1 |
Filsell, OH; Jarrett, IG; Keech, DB; Taylor, PH | 1 |
Nordlie, RC | 1 |
Nakata, Y; Okagawa, K; Sakamoto, Y | 1 |
Bergamini, E | 1 |
Lowry, OH; Needleman, P; Passonneau, JV | 1 |
Froesch, ER; Meyer, UA; Sturzenegger, V | 1 |
Rao, S; Walker, DG | 1 |
Hoekstra, WG; Menahan, LA; Schultz, LH | 1 |
2 review(s) available for phlorhizin and Alloxan Diabetes
Article | Year |
---|---|
[Sodium-glucose cotransporter type 2 inhibitors (SGLT2): from familial renal glucosuria to the treatment of type 2 diabetes mellitus].
Topics: Absorption; Animals; Benzhydryl Compounds; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Dogs; Double-Blind Method; Gluconeogenesis; Glucose; Glucosides; Glycosuria, Renal; Homeostasis; Humans; Hypoglycemic Agents; Kidney; Kidney Tubules, Proximal; Mice; Phlorhizin; Randomized Controlled Trials as Topic; Sodium-Glucose Transporter 1; Sodium-Glucose Transporter 2; Sodium-Glucose Transporter 2 Inhibitors | 2010 |
Effects of hyperglycemia on glucose transporters of the muscle: use of the renal glucose reabsorption inhibitor phlorizin to control glycemia.
Topics: Animals; Binding, Competitive; Blood Glucose; Cytochalasin B; Diabetes Complications; Diabetes Mellitus; Diabetes Mellitus, Experimental; Gene Expression Regulation; Glucose Transporter Type 4; Glycosylation; Humans; Hyperglycemia; Insulin; Insulin Resistance; Intestinal Absorption; Kidney Tubules, Proximal; Monosaccharide Transport Proteins; Multigene Family; Muscle Proteins; Muscles; Organ Specificity; Phlorhizin; Rats; Subcellular Fractions | 1992 |
122 other study(ies) available for phlorhizin and Alloxan Diabetes
Article | Year |
---|---|
Discovery of dapagliflozin: a potent, selective renal sodium-dependent glucose cotransporter 2 (SGLT2) inhibitor for the treatment of type 2 diabetes.
Topics: Administration, Oral; Animals; Benzhydryl Compounds; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Glucosides; Humans; Hypoglycemic Agents; Kidney; Rats; Sodium-Glucose Transporter 2; Sodium-Glucose Transporter 2 Inhibitors; Stereoisomerism | 2008 |
Discovery of novel N-β-D-xylosylindole derivatives as sodium-dependent glucose cotransporter 2 (SGLT2) inhibitors for the management of hyperglycemia in diabetes.
Topics: Animals; CHO Cells; Cricetinae; Cricetulus; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Glucose; Glucosides; Humans; Hyperglycemia; Hypoglycemic Agents; Indoles; Male; Mice; Mice, Inbred ICR; Rats; Rats, Sprague-Dawley; Sodium-Glucose Transporter 2 Inhibitors; Structure-Activity Relationship; Xylose | 2011 |
5a-Carba-β-D-glucopyranose derivatives as novel sodium-dependent glucose cotransporter 2 (SGLT2) inhibitors for the treatment of type 2 diabetes.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Glucose; Male; Mice; Mice, Obese; Molecular Conformation; Molecular Sequence Data; Sodium-Glucose Transporter 2; Sodium-Glucose Transporter 2 Inhibitors; Stereoisomerism; Structure-Activity Relationship; Tissue Distribution | 2011 |
Structure-activity relationship studies of 4-benzyl-1H-pyrazol-3-yl β-d-glucopyranoside derivatives as potent and selective sodium glucose co-transporter 1 (SGLT1) inhibitors with therapeutic activity on postprandial hyperglycemia.
Topics: Animals; Blood Glucose; Crystallography, X-Ray; Diabetes Mellitus, Experimental; Glucosides; Humans; Hyperglycemia; Hypoglycemic Agents; Molecular Conformation; Rats; Sodium-Glucose Transporter 1; Sodium-Glucose Transporter 2; Sodium-Glucose Transporter 2 Inhibitors; Structure-Activity Relationship | 2012 |
Identification of an oxime-containing C-glucosylarene as a potential inhibitor of sodium-dependent glucose co-transporter 2.
Topics: Administration, Intravenous; Administration, Oral; Animals; Benzhydryl Compounds; Blood Glucose; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Glucose; Glucosides; Humans; Hypoglycemic Agents; Molecular Structure; Monosaccharides; Oximes; Rats; Rats, Sprague-Dawley; Sodium-Glucose Transporter 2; Sodium-Glucose Transporter 2 Inhibitors; Structure-Activity Relationship | 2018 |
Ameliorative potential of phloridzin in type 2 diabetes-induced memory deficits in rats.
Topics: Acetylcholine; Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Humans; Male; Maze Learning; Memory; Memory Disorders; Molecular Docking Simulation; Nerve Growth Factors; Oxidative Stress; Phlorhizin; Rats; Receptor, Muscarinic M1; Scopolamine; Streptozocin; Synaptic Transmission; Up-Regulation | 2021 |
Phloretin and phlorizin mitigates inflammatory stress and alleviate adipose and hepatic insulin resistance by abrogating PPARγ S273-Cdk5 interaction in type 2 diabetic mice.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Insulin Resistance; Mice; Obesity; Phloretin; Phlorhizin; PPAR gamma | 2023 |
Marein ameliorates diabetic nephropathy by inhibiting renal sodium glucose transporter 2 and activating the AMPK signaling pathway in db/db mice and high glucose-treated HK-2 cells.
Topics: AMP-Activated Protein Kinases; Animals; Blood Glucose; Cells, Cultured; Chalcones; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Humans; Lipid Metabolism; Male; Mice; Mice, Inbred C57BL; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Phlorhizin; Signal Transduction; Sodium-Glucose Transporter 2; Sodium-Glucose Transporter 2 Inhibitors | 2020 |
Restoration of the Attenuated Neuroprotective Effect of Ischemic Postconditioning in Diabetic Mice by SGLT Inhibitor Phlorizin.
Topics: Animals; Brain Ischemia; Diabetes Mellitus, Experimental; Ischemic Postconditioning; Maze Learning; Mice; Neuroprotective Agents; Oxidative Stress; Phlorhizin; Reperfusion Injury; Sodium-Glucose Transporter 2 Inhibitors | 2020 |
Sox5 regulates beta-cell phenotype and is reduced in type 2 diabetes.
Topics: Animals; Calcium; Calcium Channels; Chromatin; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Exocytosis; Female; Gene Expression Regulation; Humans; Insulin; Insulin-Secreting Cells; Islets of Langerhans; Male; Mice; Mice, Inbred C57BL; Oligonucleotide Array Sequence Analysis; Phenotype; Phlorhizin; Rats; RNA, Small Interfering; SOXD Transcription Factors; Valproic Acid | 2017 |
SGLT2 inhibition reduces atherosclerosis by enhancing lipoprotein clearance in Ldlr
Topics: Animals; Atherosclerosis; ATP Binding Cassette Transporter, Subfamily G, Member 5; ATP Binding Cassette Transporter, Subfamily G, Member 8; Benzhydryl Compounds; Biomarkers; Blood Glucose; Cholesterol, Dietary; Cytochrome P-450 Enzyme System; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Glucosides; Heparin; Hyperlipidemias; Lipoproteins; Liver; Male; Mice, Inbred C57BL; Mice, Knockout; Monocytes; Phlorhizin; Proteoglycans; Receptors, LDL; Sodium-Glucose Transporter 2 Inhibitors; Streptozocin | 2018 |
Phloridzin, an Apple Polyphenol, Exerted Unfavorable Effects on Bone and Muscle in an Experimental Model of Type 2 Diabetes in Rats.
Topics: Animals; Bone and Bones; Bone Density; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Diet, High-Fat; Female; Hyperglycemia; Hypoglycemic Agents; Malus; Muscle, Skeletal; Phloretin; Phlorhizin; Polyphenols; Rats; Rats, Wistar | 2018 |
Comparative oral and intravenous pharmacokinetics of phlorizin in rats having type 2 diabetes and in normal rats based on phase II metabolism.
Topics: Administration, Oral; Animals; Area Under Curve; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Half-Life; Injections, Intravenous; Male; Molecular Structure; Phlorhizin; Random Allocation; Rats; Rats, Wistar; Research Design; Specific Pathogen-Free Organisms | 2019 |
Anti-hyperglycemic effect of the aqueous extract of banana infructescence stalks in streptozotocin-induced diabetic rats.
Topics: Animals; Biological Transport; Blood Glucose; Caco-2 Cells; Colon; Diabetes Mellitus, Experimental; Down-Regulation; Enterocytes; Glucose; Glucose Transporter Type 2; Humans; Hypoglycemic Agents; Jejunum; Male; Musa; Phloretin; Phlorhizin; Phosphates; Phytotherapy; Plant Extracts; Plant Structures; Rats; Rats, Sprague-Dawley; Sodium-Glucose Transporter 1; Sodium-Potassium-Exchanging ATPase | 2013 |
Effects of phlorizin on diabetic retinopathy according to isobaric tags for relative and absolute quantification-based proteomics in db/db mice.
Topics: Animals; Apoptosis; Blood Glucose; Blotting, Western; Body Weight; Computational Biology; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Eye Proteins; Fasting; Glial Fibrillary Acidic Protein; Glycation End Products, Advanced; In Situ Nick-End Labeling; Isotope Labeling; Male; Mice; Mice, Inbred C57BL; Neuroglia; Phlorhizin; Proteomics; Retinal Degeneration; Subcellular Fractions | 2013 |
Decrease of FGF receptor (FGFR) and interstitial fibrosis in the kidney of streptozotocin-induced diabetic rats.
Topics: 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Dogs; Fibroblast Growth Factor-23; Fibrosis; Glucuronidase; Hyperglycemia; Insulin; Kidney; Kidney Tubules; Klotho Proteins; Madin Darby Canine Kidney Cells; Male; Mice; Phlorhizin; Rats; Rats, Wistar; Receptors, Fibroblast Growth Factor; Superoxides | 2014 |
Phlorizin pretreatment reduces acute renal toxicity in a mouse model for diabetic nephropathy.
Topics: Animals; Antibiotics, Antineoplastic; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Dose-Response Relationship, Drug; Insulin-Secreting Cells; Kidney; Male; Mice; Phlorhizin; Sodium-Glucose Transporter 1; Streptozocin | 2013 |
Effects of combination therapy with vildagliptin and valsartan in a mouse model of type 2 diabetes.
Topics: Adamantane; Adiponectin; Angiotensin II Type 1 Receptor Blockers; Animals; Blood Glucose; Cytokines; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Dipeptidyl-Peptidase IV Inhibitors; Disease Models, Animal; Drug Therapy, Combination; Fatty Liver; Homeodomain Proteins; Inflammation; Insulin; Insulin Resistance; Insulin Secretion; Insulin-Secreting Cells; Mice; Mice, Inbred C57BL; Nitriles; Phlorhizin; Pyrrolidines; Tetrazoles; Trans-Activators; Valine; Valsartan; Vildagliptin | 2013 |
mTORC1-independent reduction of retinal protein synthesis in type 1 diabetes.
Topics: alpha-Crystallin A Chain; Animals; beta-Crystallin B Chain; Blood Glucose; Carrier Proteins; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Eye Proteins; Hyperglycemia; Insulin; Intracellular Signaling Peptides and Proteins; Male; Mechanistic Target of Rapamycin Complex 2; Mice; Multiprotein Complexes; Phlorhizin; Phosphoproteins; Protein Biosynthesis; Proto-Oncogene Proteins c-akt; Rapamycin-Insensitive Companion of mTOR Protein; Rats; Receptor, Insulin; Regulatory-Associated Protein of mTOR; Retina; RNA, Ribosomal; TOR Serine-Threonine Kinases | 2014 |
KATP channel as well as SGLT1 participates in GIP secretion in the diabetic state.
Topics: Animals; Diabetes Mellitus, Experimental; Diazoxide; Gastric Inhibitory Polypeptide; Glucose; KATP Channels; Mice; Phlorhizin; Potassium Channels, Inwardly Rectifying; Sodium-Glucose Transporter 1; Sulfonylurea Compounds | 2014 |
Contribution of hyperglycemia on diabetic complications in obese type 2 diabetic SDT fatty rats: effects of SGLT inhibitor phlorizin.
Topics: Albuminuria; Animals; Blood Glucose; Diabetes Complications; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Diabetic Neuropathies; Diabetic Retinopathy; Disease Models, Animal; Female; Hyperglycemia; Kidney Tubules; Phlorhizin; Rats, Inbred Strains; Rats, Sprague-Dawley; Sodium-Glucose Transport Proteins | 2015 |
Acute SGLT inhibition normalizes O2 tension in the renal cortex but causes hypoxia in the renal medulla in anaesthetized control and diabetic rats.
Topics: Anesthesia; Animals; Arterial Pressure; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Hypoxia; Kidney Cortex; Kidney Medulla; Male; Oxygen Consumption; Phlorhizin; Rats; Rats, Sprague-Dawley; Sodium; Sodium-Glucose Transport Proteins; Urodynamics | 2015 |
Reduction in the amplitude of shortening and Ca(2+) transient by phlorizin and quercetin-3-O-glucoside in ventricular myocytes from streptozotocin-induced diabetic rats.
Topics: Animals; Calcium; Cells, Cultured; Diabetes Mellitus, Experimental; Flavonoids; Glucosides; Heart Ventricles; Myocytes, Cardiac; Phlorhizin; Quercetin; Rats; Sarcoplasmic Reticulum; Streptozocin | 2016 |
SGLT1 activity in lung alveolar cells of diabetic rats modulates airway surface liquid glucose concentration and bacterial proliferation.
Topics: Alloxan; Alveolar Epithelial Cells; Animals; Bronchoalveolar Lavage Fluid; Bronchodilator Agents; Colony Count, Microbial; Diabetes Mellitus, Experimental; Gene Expression Regulation; Glucose; Isoproterenol; Lung; Male; Methicillin-Resistant Staphylococcus aureus; Phlorhizin; Pneumonia, Bacterial; Pseudomonas aeruginosa; Pseudomonas Infections; Rats; Rats, Wistar; Sodium-Glucose Transporter 1; Staphylococcal Infections | 2016 |
Sodium tungstate decreases sucrase and Na+/D-glucose cotransporter in the jejunum of diabetic rats.
Topics: Administration, Oral; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Down-Regulation; Glucose; Hypoglycemic Agents; Immunohistochemistry; Intestinal Mucosa; Jejunum; Male; Microvilli; Phlorhizin; Rats; Rats, Wistar; RNA, Messenger; Sodium-Glucose Transporter 1; Sucrase; Time Factors; Tungsten Compounds | 2008 |
Role of hyperglycaemia in the pathogenesis of hypotension observed in type-1 diabetic rats.
Topics: Animals; Arecoline; Baroreflex; Cell Line; Cholinergic Agonists; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Gene Expression; Glucose; Hyperglycemia; Hypotension; Insulin; Male; Phenylephrine; Phlorhizin; Rats; Rats, Wistar; Receptor, Muscarinic M2; RNA, Messenger | 2008 |
Phlorizin prevents glomerular hyperfiltration but not hypertrophy in diabetic rats.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Glomerular Filtration Rate; Hypertrophy; Kidney Glomerulus; Male; Organ Size; Phlorhizin; Proteinuria; Rats; Rats, Inbred F344 | 2008 |
Insulin stimulates Akt translocation to mitochondria: implications on dysregulation of mitochondrial oxidative phosphorylation in diabetic myocardium.
Topics: Animals; Biological Transport; Blotting, Western; Cells, Cultured; Diabetes Mellitus, Experimental; Electron Transport Complex IV; Electrophoresis, Polyacrylamide Gel; Heart; Hyperglycemia; Hypoglycemic Agents; Insulin; Mice; Mice, Inbred C57BL; Mitochondria, Heart; Myocardium; Oxidative Phosphorylation; Phlorhizin; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley | 2009 |
Dietary phloridzin reduces blood glucose levels and reverses Sglt1 expression in the small intestine in streptozotocin-induced diabetic mice.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Blood Glucose; Cytochrome P450 Family 2; Diabetes Mellitus, Experimental; Disease Models, Animal; Gene Expression; Humans; Intestine, Small; Male; Mice; Mice, Inbred BALB C; Phlorhizin; Sodium-Glucose Transporter 1; Steroid Hydroxylases; Streptozocin | 2009 |
Molecular mechanisms of tungstate-induced pancreatic plasticity: a transcriptomics approach.
Topics: Animals; Cell Proliferation; Diabetes Mellitus, Experimental; Gene Expression Profiling; Hyperglycemia; Hypoglycemic Agents; Insulin-Secreting Cells; Male; Mitogen-Activated Protein Kinases; Oligonucleotide Array Sequence Analysis; Pancreas; Phlorhizin; Rats; Rats, Wistar; Streptozocin; Tungsten Compounds | 2009 |
Reduced activity and expression of mitochondrial citrate carrier in streptozotocin-induced diabetic rats.
Topics: Analysis of Variance; Animals; Blood Glucose; Blotting, Western; Body Weight; Carrier Proteins; Cholesterol; Citric Acid; Diabetes Mellitus, Experimental; Insulin; Liver; Male; Mitochondria, Liver; Mitochondrial Membranes; Organ Size; Phlorhizin; Phospholipids; Rats; Rats, Wistar; RNA, Messenger | 2010 |
The action of dexyxycorticosterone and cortin on diabetes caused by phlorhidzin in rats.
Topics: Adrenal Glands; Animals; Diabetes Mellitus, Experimental; Phlorhizin; Tissue Extracts | 1946 |
Decrease of Klotho in the kidney of streptozotocin-induced diabetic rats.
Topics: 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt; Animals; Antioxidants; Blood Glucose; Blood Urea Nitrogen; Cell Line; Creatinine; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Dogs; Glucose; Glucuronidase; Insulin; Kidney; Kidney Tubules; Klotho Proteins; Male; Phlorhizin; Rats; Rats, Wistar; Reactive Oxygen Species | 2010 |
Changes of CCAAT enhancer-binding proteins (CEBPs) in the lung of streptozotocin-induced diabetic rats.
Topics: Animals; CCAAT-Enhancer-Binding Protein-alpha; CCAAT-Enhancer-Binding Protein-beta; CCAAT-Enhancer-Binding Protein-delta; Diabetes Mellitus, Experimental; Glucose; Humans; Lung; Male; Phlorhizin; Rats; Rats, Wistar; Streptozocin | 2011 |
Pharmacological profile of ipragliflozin (ASP1941), a novel selective SGLT2 inhibitor, in vitro and in vivo.
Topics: Animals; Blood Glucose; Carbohydrate Metabolism; CHO Cells; Cricetinae; Cricetulus; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Gastrointestinal Tract; Glucosides; Humans; Hypoglycemic Agents; Insulin; Male; Mice; Mice, Inbred ICR; Phlorhizin; Rats; Rats, Sprague-Dawley; Sodium-Glucose Transporter 1; Sodium-Glucose Transporter 2 Inhibitors; Thiophenes | 2012 |
Phloridzin reduces blood glucose levels and improves lipids metabolism in streptozotocin-induced diabetic rats.
Topics: Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Drinking Behavior; Feeding Behavior; Insulin; Lipid Metabolism; Lipids; Male; Phlorhizin; Rats; Rats, Wistar | 2012 |
Increase of ATP-sensitive potassium (K(ATP)) channels in the heart of type-1 diabetic rats.
Topics: 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt; Animals; ATP-Binding Cassette Transporters; Blood Glucose; Blood Pressure; Blotting, Northern; Blotting, Western; Cells, Cultured; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Diazoxide; Dose-Response Relationship, Drug; Down-Regulation; Free Radical Scavengers; Heart Rate; Hypoglycemic Agents; Insulin; KATP Channels; Male; Myocytes, Cardiac; Phlorhizin; Potassium Channels, Inwardly Rectifying; Rats; Rats, Wistar; Receptors, Drug; RNA, Messenger; Streptozocin; Sulfonylurea Receptors; Time Factors; Up-Regulation | 2012 |
Sodium-glucose cotransporter inhibition prevents oxidative stress in the kidney of diabetic rats.
Topics: Animals; Catalase; Diabetes Mellitus, Experimental; Glutathione Peroxidase; Immunohistochemistry; Kidney; Male; Oxidative Stress; Phlorhizin; Rats; Rats, Wistar; Sodium-Glucose Transporter 2; Sodium-Glucose Transporter 2 Inhibitors; Superoxide Dismutase; Tyrosine | 2012 |
Mechanisms by which bis(maltolato)oxovanadium(IV) normalizes phosphoenolpyruvate carboxykinase and glucose-6-phosphatase expression in streptozotocin-diabetic rats in vivo.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Gene Expression; Glucose-6-Phosphatase; Hypoglycemic Agents; Insulin; Kidney; Liver; Male; Phlorhizin; Phosphoenolpyruvate Carboxykinase (GTP); Pyrones; Rats; Rats, Wistar; RNA, Messenger; Vanadates | 2002 |
High blood glucose and osmolality, but not high urinary glucose and osmolality, affect neuronal nitric oxide synthase expression in diabetic rat kidney.
Topics: Actins; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Disease Models, Animal; Kidney; Male; Nerve Tissue Proteins; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Osmolar Concentration; Phlorhizin; Rats; Rats, Wistar; RNA, Messenger | 2003 |
Evidence for rapid "metabolic switching" through lipoprotein lipase occupation of endothelial-binding sites.
Topics: Acute Disease; Animals; Binding Sites; Blood Glucose; Diabetes Mellitus, Experimental; Dichloroacetic Acid; Endothelial Cells; Endothelium, Vascular; Fatty Acids, Nonesterified; Gene Expression Regulation, Enzymologic; Hyperglycemia; Insulin; Lipolysis; Lipoprotein Lipase; Male; Malonyl Coenzyme A; Milk; Perfusion; Phlorhizin; Pyruvate Dehydrogenase Complex; Rats; Rats, Wistar; Streptozocin; Time Factors | 2003 |
[Alloxan diabetes and phlorhizin acidosis].
Topics: Acidosis; Animals; Diabetes Mellitus, Experimental; Insulin; Phlorhizin | 1953 |
[Biohistochemical studies on renal phosphatases in dogs with phlorhizin diabetes after vitamin and hormone administration].
Topics: Animals; Diabetes Mellitus, Experimental; Dogs; Hormones; Kidney; Phlorhizin; Phosphoric Monoester Hydrolases; Vitamin A; Vitamin K; Vitamins | 1954 |
[Effect of heparin on phlorhizin diabetes in rats].
Topics: Animals; Diabetes Mellitus, Experimental; Heparin; Phlorhizin; Rats | 1956 |
[The effect of Nl, n-butylbiguanide (W37) and Nl, beta-phenylethylbiguanide (W32) on alloxan and phlorrhizin diabetes and intestinal glucose absorption in rats].
Topics: Alloxan; Animals; Buformin; Diabetes Mellitus, Experimental; Hypoglycemic Agents; Intestinal Absorption; Intestines; Phenformin; Phlorhizin; Rats | 1962 |
Phlorizin-like effect of Fraxinus excelsior in normal and diabetic rats.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Fraxinus; Hypoglycemic Agents; Insulin; Phlorhizin; Phytotherapy; Plant Extracts; Rats; Rats, Wistar; Seeds; Streptozocin; Vanadates | 2004 |
Posttranslational regulation of NO synthase activity in the renal medulla of diabetic rats.
Topics: Animals; Diabetes Mellitus, Experimental; Kidney Medulla; Male; Nitric Oxide Synthase; Phlorhizin; Phosphorylation; Polyuria; Protein Processing, Post-Translational; Rats; Rats, Sprague-Dawley | 2005 |
Prevailing hyperglycemia is critical in the regulation of glucose metabolism during exercise in poorly controlled alloxan-diabetic dogs.
Topics: Alloxan; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Dogs; Drug Combinations; Exercise Test; Fatty Acids, Nonesterified; Glucose; Homeostasis; Hyperglycemia; Men; Muscle, Skeletal; Phlorhizin; Physical Exertion | 2005 |
Inhibition of intestinal and renal Na+-glucose cotransporter by naringenin.
Topics: Animals; Diabetes Mellitus, Experimental; Flavanones; Glucose; Intestine, Small; Kidney Cortex; Male; Microvilli; Phlorhizin; Rabbits; Rats; Rats, Wistar; Sodium-Glucose Transport Proteins | 2006 |
Increase of peroxisome proliferator-activated receptor delta gene expression in the lungs of streptozotocin-induced diabetic rats.
Topics: Animals; Blood Glucose; Blotting, Northern; Blotting, Western; Diabetes Mellitus, Experimental; Gene Expression Regulation; Hypoglycemic Agents; Injections, Intraperitoneal; Insulin, Long-Acting; Lung; Male; Phlorhizin; PPAR delta; Rats; Rats, Wistar; RNA, Messenger; Streptozocin | 2007 |
Downregulation of the constitutively expressed Hsc70 in diabetic myocardium is mediated by insulin deficiency.
Topics: Adenoviridae; Adipose Tissue; Animals; Animals, Newborn; Cell Line; Cells, Cultured; Diabetes Mellitus, Experimental; Down-Regulation; Genetic Vectors; HSC70 Heat-Shock Proteins; HSP70 Heat-Shock Proteins; Immunoblotting; Insulin; Insulin-Like Growth Factor I; Kidney; Male; Muscle, Skeletal; Myocardium; Phlorhizin; Rats; Receptor, IGF Type 1; Sodium-Glucose Transporter 1; Transduction, Genetic | 2006 |
Na(+) -glucose transporter-2 messenger ribonucleic acid expression in kidney of diabetic rats correlates with glycemic levels: involvement of hepatocyte nuclear factor-1alpha expression and activity.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Electrophoretic Mobility Shift Assay; Hepatocyte Nuclear Factor 1-alpha; Hyperglycemia; Hypoglycemic Agents; Immunoprecipitation; Insulin; Kidney; Male; Phlorhizin; Rats; Rats, Wistar; RNA, Messenger; Sodium-Glucose Transporter 2 | 2008 |
Concentrations of free glucogenic amino acids in livers of rats subjected to various metabolic stresses.
Topics: Alanine; Amino Acids; Animals; Aspartic Acid; Diabetes Mellitus, Experimental; Gluconeogenesis; Glutamates; Glutamine; Hypoxia; Insulin; Liver; Male; Phlorhizin; Rats; Serine; Starvation; Threonine; Transaminases | 1967 |
Characteristics of intestinal glucose secretion in normal and diabetic rats.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Glucose; Intestinal Mucosa; Male; Mannitol; Perfusion; Phlorhizin; Rats; Rats, Inbred Strains; Reference Values; Streptozocin | 1982 |
Glycogen repletion in different skeletal muscles from diabetic rats.
Topics: Animals; Antibodies; Diabetes Mellitus, Experimental; Glycogen; Insulin; Male; Muscles; Phlorhizin; Rats; Rats, Inbred Strains; Streptozocin; Time Factors | 1984 |
Intestinal sugar transport in experimental diabetes.
Topics: 3-O-Methylglucose; Animals; Blood Glucose; Cycloheximide; Diabetes Mellitus, Experimental; Galactose; Glucose; Hyperglycemia; Insulin; Intestinal Absorption; Intestine, Small; Male; Methylglucosides; Methylglycosides; Phloretin; Phlorhizin; Rats; Streptozocin | 1981 |
In situ kinetics of glucose transport across the blood-retinal barrier in normal rats and rats with streptozocin-induced diabetes.
Topics: Acetazolamide; Animals; Biological Transport; Diabetes Mellitus, Experimental; Electroretinography; Female; Glucose; Ions; Kinetics; Male; Phloretin; Phlorhizin; Rats; Rats, Inbred Strains; Retina | 1982 |
Effects of phlorizin and acipimox on insulin resistance in STZ-diabetic rats.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Fatty Acids, Nonesterified; Female; Hypolipidemic Agents; Insulin Resistance; Phlorhizin; Pyrazines; Rats; Rats, Sprague-Dawley; Streptozocin | 1995 |
Mechanisms and time course of impaired skeletal muscle glucose transport activity in streptozocin diabetic rats.
Topics: Animals; Biological Transport; Diabetes Mellitus, Experimental; Glucose; Glucose Transporter Type 1; Glucose Transporter Type 4; Male; Monosaccharide Transport Proteins; Muscle Proteins; Muscle, Skeletal; Phlorhizin; Rats; Rats, Sprague-Dawley; Streptozocin | 1995 |
The effects of streptozotocin diabetes on sodium-glucose transporter (SGLT1) expression and function in rat jejunal and ileal villus-attached enterocytes.
Topics: Animals; Biological Transport; Blotting, Western; Diabetes Mellitus, Experimental; Glucose; Ileum; Immunoenzyme Techniques; Jejunum; Male; Membrane Glycoproteins; Membrane Proteins; Microvilli; Monosaccharide Transport Proteins; Phlorhizin; Rats; Rats, Sprague-Dawley; Sodium; Sodium-Glucose Transporter 1 | 1995 |
Persistence of disturbed adipocyte metabolism in streptozocin-induced diabetic rats despite near-euglycemia with phlorizin.
Topics: Adipocytes; Animals; Deoxyglucose; Diabetes Mellitus, Experimental; Glucose-6-Phosphate; Glucosephosphates; Insulin; Male; Phlorhizin; Rats; Rats, Sprague-Dawley | 1994 |
Regulation of glucose transporter and hexokinase II expression in tissues of diabetic rats.
Topics: Adipose Tissue; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Glucose Transporter Type 4; Hexokinase; Insulin; Male; Monosaccharide Transport Proteins; Muscle Proteins; Muscles; Myocardium; Phlorhizin; Rats; Rats, Wistar; RNA, Messenger | 1993 |
Opposite effects of hyperglycemia and insulin deficiency on liver glycogen synthase phosphatase activity in the diabetic rat.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Glucagon; Glucokinase; Glucose; Glucose-6-Phosphatase; Glycogen-Synthase-D Phosphatase; Hexosephosphates; Hyperglycemia; Insulin; Liver; Male; Phlorhizin; Rats; Rats, Sprague-Dawley | 1993 |
Changes in uncoupling protein and GLUT4 glucose transporter expressions in interscapular brown adipose tissue of diabetic rats: relative roles of hyperglycaemia and hypoinsulinaemia.
Topics: Adipose Tissue, Brown; Animals; Blood Glucose; Carrier Proteins; Diabetes Mellitus, Experimental; Gene Expression; Glucose Transporter Type 4; Insulin; Ion Channels; Male; Membrane Proteins; Mitochondrial Proteins; Monosaccharide Transport Proteins; Muscle Proteins; Phlorhizin; Rats; Rats, Wistar; RNA, Messenger; Uncoupling Protein 1 | 1993 |
Phlorizin treatment of diabetic rats partially reverses the abnormal expression of genes involved in hepatic glucose metabolism.
Topics: Animals; Diabetes Mellitus, Experimental; Gene Expression Regulation; Glucokinase; Gluconeogenesis; Glucose; Glycolysis; Isoenzymes; Liver; Male; Monosaccharide Transport Proteins; Phlorhizin; Phosphoenolpyruvate Carboxykinase (GTP); Pyruvate Kinase; Rats; Rats, Wistar; RNA, Messenger | 1993 |
Glucose regulates in vivo glucose-6-phosphatase gene expression in the liver of diabetic rats.
Topics: Animals; Diabetes Mellitus, Experimental; Energy Metabolism; Gene Expression Regulation, Enzymologic; Glucose; Glucose-6-Phosphatase; Hyperglycemia; Insulin; Liver; Male; Phlorhizin; Rats; Rats, Sprague-Dawley; RNA, Messenger | 1996 |
Phlorizin or vanadate treatment reverses impaired expression of albumin and hepatocyte nuclear factor 1 in diabetic rats.
Topics: Animals; Base Sequence; Binding Sites; Blood Glucose; Diabetes Mellitus, Experimental; DNA-Binding Proteins; Hepatocyte Nuclear Factor 1; Hepatocyte Nuclear Factor 1-alpha; Hepatocyte Nuclear Factor 1-beta; Liver; Male; Molecular Sequence Data; Nuclear Proteins; Oligodeoxyribonucleotides; Phlorhizin; Promoter Regions, Genetic; Rats; Rats, Sprague-Dawley; Reference Values; RNA, Messenger; Serum Albumin; Suppression, Genetic; Transcription Factors; Transcription, Genetic; Vanadates; Vanadium Compounds | 1996 |
Na(+)-glucose cotransporter inhibitors as antidiabetics. I. Synthesis and pharmacological properties of 4'-dehydroxyphlorizin derivatives based on a new concept.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Erythrocytes; Glucose; Glucose Transporter Type 1; Humans; Hypoglycemic Agents; In Vitro Techniques; Intestinal Absorption; Intestine, Small; Kidney; Male; Membrane Glycoproteins; Mice; Mice, Inbred Strains; Microvilli; Monosaccharide Transport Proteins; Phlorhizin; Rats; Rats, Sprague-Dawley; Sodium-Glucose Transporter 1 | 1996 |
Mechanisms of postabsorptive hyperglycemia in streptozotocin diabetic rats.
Topics: Absorption; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Glucagon; Glucose; Glycogen; Glycosuria; Hyperglycemia; Insulin; Liver; Male; Phlorhizin; Rats; Rats, Wistar; Time Factors | 1996 |
Temporal association between lens protein glycation and cataract development in diabetic rats.
Topics: Animals; Blood Glucose; Cataract; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Glycated Hemoglobin; Glycation End Products, Advanced; Glycoproteins; Glycosylation; Insulin; Lens, Crystalline; Molecular Weight; Phlorhizin; Rats; Rats, Wistar; Reference Values | 1997 |
Insulin-independent acute restoration of euglycemia normalizes the impaired glucose clearance during exercise in diabetic dogs.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Dogs; Exercise Test; Fatty Acids, Nonesterified; Glucose; Insulin; Kinetics; Male; Metabolic Clearance Rate; Phlorhizin; Physical Conditioning, Animal; Physical Exertion; Reference Values | 1997 |
Relative contribution of glycogenolysis and gluconeogenesis to hepatic glucose production in control and diabetic rats. A re-examination in the presence of euglycaemia.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Disease Models, Animal; Fatty Acids, Nonesterified; Gluconeogenesis; Glucose; Glucose Clamp Technique; Glucose-6-Phosphate; Hyperglycemia; Hyperinsulinism; Hypoglycemic Agents; Insulin; Liver; Liver Glycogen; Male; Phlorhizin; Rats; Rats, Sprague-Dawley; Reference Values; Sodium Chloride | 1998 |
Quantitative measurement of islet glucagon response to hypoglycemia by confocal fluorescence imaging in diabetic rats: effects of phlorizin treatment.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Fluorescent Antibody Technique, Direct; gamma-Aminobutyric Acid; Glucagon; Hypoglycemia; Hypoglycemic Agents; Image Processing, Computer-Assisted; Insulin; Islets of Langerhans; Male; Microscopy, Confocal; Phlorhizin; Rats; Rats, Sprague-Dawley | 1997 |
Upregulation of hypothalamic nitric oxide synthase gene expression in streptozotocin-induced diabetic rats.
Topics: Animals; Arginine Vasopressin; Diabetes Mellitus, Experimental; Gene Expression; Gene Expression Regulation, Enzymologic; Genes; Histocytochemistry; Hypoglycemic Agents; Hypothalamus; Insulin; Male; NADPH Dehydrogenase; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Oxytocin; Phlorhizin; Rats; Rats, Wistar; RNA, Messenger; Staining and Labeling | 1998 |
Increased expression of liver PKC alpha in hypoinsulinemic diabetic rats: a post-translational effect.
Topics: Animals; Blood Glucose; Cell Nucleus; Cytosol; Diabetes Mellitus, Experimental; Gene Expression; Insulin; Isoenzymes; Liver; Male; Microsomes, Liver; Mitochondria, Liver; Phlorhizin; Protein Kinase C; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger | 1998 |
Treatment of streptozotocin-induced diabetic rats with vanadate and phlorizin prevents the over-expression of the liver insulin receptor gene.
Topics: Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Gene Expression; Insulin; Liver; Male; Phlorhizin; Rats; Rats, Wistar; Receptor, Insulin; RNA, Messenger; Subcellular Fractions; Tumor Cells, Cultured; Vanadates | 1999 |
Chronic hyperglycemia triggers loss of pancreatic beta cell differentiation in an animal model of diabetes.
Topics: Animals; Blood Glucose; Body Weight; Cell Differentiation; Chronic Disease; Diabetes Mellitus, Experimental; Disease Models, Animal; DNA Primers; Fatty Acids, Nonesterified; Humans; Hyperglycemia; Insulin; Islets of Langerhans; Male; Pancreatic Hormones; Phlorhizin; Rats; Rats, Sprague-Dawley; RNA, Messenger | 1999 |
Leptin restores euglycemia and normalizes glucose turnover in insulin-deficient diabetes in the rat.
Topics: Animals; Diabetes Mellitus, Experimental; Drug Evaluation, Preclinical; Glucose; Glucose Clamp Technique; Insulin; Leptin; Male; Obesity; Phlorhizin; Proteins; Rats; Rats, Sprague-Dawley | 1999 |
Glucose rapidly decreases plasma membrane GLUT4 content in rat skeletal muscle.
Topics: Animals; Blood Glucose; Cell Membrane; Diabetes Mellitus, Experimental; Glucose; Glucose Transporter Type 4; Insulin; Insulin Resistance; Male; Monosaccharide Transport Proteins; Muscle Proteins; Muscle, Skeletal; Phlorhizin; Rats; Rats, Sprague-Dawley | 1999 |
Rat tissue collagen modified by advanced glycation: correlation with duration of diabetes and glycemic control.
Topics: Alloxan; Animals; Aorta; Blood Glucose; Collagen; Diabetes Mellitus, Experimental; Enzyme-Linked Immunosorbent Assay; Glycation End Products, Advanced; Insulin; Kidney Tubules; Phlorhizin; Rats; Rats, Wistar; Tendons | 1999 |
Evidence for glucose/hexosamine in vivo regulation of insulin/IGF-I hybrid receptor assembly.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Glucosamine; Insulin; Insulin-Like Growth Factor I; Kinetics; Male; Muscle, Skeletal; Phlorhizin; Protein Multimerization; Rats; Rats, Sprague-Dawley; Receptor, IGF Type 1; Receptor, Insulin; Reference Values | 1999 |
Glomerular hyperfiltration in experimental diabetes mellitus: potential role of tubular reabsorption.
Topics: Animals; Biological Transport, Active; Chlorides; Diabetes Mellitus, Experimental; Feedback; Glomerular Filtration Rate; Glucose; Hydrostatic Pressure; Kidney Glomerulus; Kidney Tubules; Male; Models, Biological; Nephrons; Phlorhizin; Potassium; Rats; Rats, Wistar; Sodium | 1999 |
Experimental study on the treatment of diabetes by phloridzin in rats.
Topics: Animals; Diabetes Mellitus, Experimental; Hypoglycemic Agents; Insulin; Insulin Resistance; Male; Pancreas; Pancreatectomy; Phlorhizin; Random Allocation; Rats; Rats, Wistar | 1998 |
Vanadate restores glucose 6-phosphate in diabetic rats: a mechanism to enhance glucose metabolism.
Topics: Adipose Tissue; Animals; Cells, Cultured; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Glucose; Glucose-6-Phosphate; Insulin; Lipids; Liver; Male; Muscle, Skeletal; Phlorhizin; Rats; Rats, Wistar; Streptozocin; Vanadates | 2000 |
Increase of beta-endorphin biosynthesis in the adrenal gland of streptozotocin-induced diabetic rats.
Topics: Adrenal Medulla; Animals; beta-Endorphin; Blood Glucose; Diabetes Mellitus, Experimental; Glucose; Homeostasis; Immunohistochemistry; Insulin; Male; Phlorhizin; Pro-Opiomelanocortin; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Up-Regulation | 2002 |
Diabetes mellitus: changes in the transport properties of isolated intestinal microvillous membranes.
Topics: Animals; Anti-Bacterial Agents; Biological Transport; Cell Membrane; Diabetes Mellitus, Experimental; Glucose; Gramicidin; Intestinal Mucosa; Intestine, Small; Phlorhizin; Rats; Sodium Chloride; Thiocyanates | 1975 |
Renin-angiotensin system in phlorhizin compared with alloxan diabetes in the rat.
Topics: Alloxan; Angiotensin II; Angiotensinogen; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Kidney; Male; Phlorhizin; Rats; Renin; Water-Electrolyte Balance | 1979 |
Heterogeneity of plasma glucagon immunoreactivity in normal, depancreatized, and alloxan-diabetic dogs.
Topics: Animals; Arginine; Chromatography, Gel; Diabetes Mellitus, Experimental; Dogs; Glucagon; Insulin; Iodine Radioisotopes; Molecular Weight; Pancreas; Pancreatectomy; Phlorhizin; Somatostatin | 1975 |
Differential tissue regulation of insulin-like growth factor binding proteins in experimental diabetes mellitus in the rat.
Topics: Animals; Brain; Carrier Proteins; Cerebral Cortex; Cross-Linking Reagents; Diabetes Mellitus, Experimental; Electrophoresis, Polyacrylamide Gel; Hypothalamus; Insulin; Insulin-Like Growth Factor Binding Protein 1; Kidney; Liver; Male; Molecular Weight; Organ Specificity; Phlorhizin; Pituitary Gland; Rats; Rats, Sprague-Dawley; Reference Values; Somatomedins; Succinimides; Vanadates | 1992 |
Glycaemia regulates the glucose transporter number in the plasma membrane of rat skeletal muscle.
Topics: Animals; Blood Glucose; Blotting, Western; Cell Membrane; Cytochalasin B; Diabetes Mellitus, Experimental; Insulin; Male; Monosaccharide Transport Proteins; Muscles; Phlorhizin; Radioimmunoassay; Rats; Rats, Inbred Strains; RNA, Messenger; Streptozocin | 1992 |
Tubular sodium handling and tubuloglomerular feedback in experimental diabetes mellitus.
Topics: Animals; Biological Transport; Diabetes Mellitus, Experimental; Feedback; Kidney Glomerulus; Kidney Tubules; Male; Mannitol; Monosaccharide Transport Proteins; Phlorhizin; Rats; Rats, Inbred Strains; Sodium; Streptozocin | 1991 |
Altered glucose carrier expression: mechanism of intestinal adaptation during streptozocin-induced diabetes in rats.
Topics: 3-O-Methylglucose; Acute Disease; Animals; Chronic Disease; Diabetes Mellitus, Experimental; Ileum; Intestinal Mucosa; Intestines; Jejunum; Male; Methylglucosides; Monosaccharide Transport Proteins; Phlorhizin; Rats; Rats, Inbred Lew; Reference Values | 1991 |
Normalization of blood glucose in diabetic rats with phlorizin treatment reverses insulin-resistant glucose transport in adipose cells without restoring glucose transporter gene expression.
Topics: Adipose Tissue; Animals; Blood Glucose; Blotting, Northern; Body Weight; Brain; Cell Fractionation; Diabetes Mellitus, Experimental; Gene Expression; Insulin; Male; Monosaccharide Transport Proteins; Muscles; Phlorhizin; Rats; Rats, Inbred Strains; RNA, Messenger; Tumor Cells, Cultured | 1991 |
Abnormal B-cell function in rats with non-insulin-dependent diabetes induced by neonatal streptozotocin: effect of in vivo insulin, phlorizin, or vanadate treatments.
Topics: Animals; Arginine; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Glucose; In Vitro Techniques; Insulin; Insulin Secretion; Male; Pancreas; Phlorhizin; Rats; Rats, Inbred Strains; Vanadates | 1991 |
Insulin regulates Na+/glucose cotransporter activity in rat small intestine.
Topics: Alkaline Phosphatase; Animals; Cell Membrane; Cell-Free System; Diabetes Mellitus, Experimental; Glucose; In Vitro Techniques; Insulin; Intestine, Small; Microvilli; Monosaccharide Transport Proteins; Phlorhizin; Rats; Starvation; Subcellular Fractions; Sucrase | 1991 |
Diabetes mellitus and sugar transport across the brush-border and basolateral membranes of rat jejunal enterocytes.
Topics: Animals; Basement Membrane; Biological Transport, Active; Diabetes Mellitus, Experimental; Galactose; Intestinal Absorption; Jejunum; Male; Microvilli; Phlorhizin; Rats; Rats, Inbred Strains; Streptozocin | 1990 |
Regulation of glucose transporter messenger RNA levels in rat adipose tissue by insulin.
Topics: Adipose Tissue; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Epididymis; Fasting; Gene Expression Regulation; Hyperglycemia; Insulin; Male; Monosaccharide Transport Proteins; Phlorhizin; Rats; Rats, Inbred Strains; RNA, Messenger; Stimulation, Chemical; Streptozocin | 1990 |
Effect of in vivo vanadate treatment on insulin receptor tyrosine kinase activity in partially pancreatectomized diabetic rats.
Topics: Animals; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Insulin; Liver; Male; Osmolar Concentration; Pancreatectomy; Phlorhizin; Phosphoric Monoester Hydrolases; Phosphorylation; Protein-Tyrosine Kinases; Rats; Rats, Inbred Strains; Receptor, Insulin; Vanadates | 1990 |
Insulin resistance in rats with non-insulin-dependent diabetes induced by neonatal (5 days) streptozotocin: evidence for reversal following phlorizin treatment.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Glucose Clamp Technique; Glucose Tolerance Test; Insulin; Insulin Resistance; Insulin Secretion; Kinetics; Phlorhizin; Rats; Rats, Inbred Strains; Reference Values | 1990 |
Correction of chronic hyperglycemia with vanadate, but not with phlorizin, normalizes in vivo glycogen repletion and in vitro glycogen synthase activity in diabetic skeletal muscle.
Topics: Animals; Chronic Disease; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Glucose Clamp Technique; Glycogen; Glycogen Synthase; Hyperglycemia; Insulin; Liver; Male; Muscles; Phlorhizin; Rats; Rats, Inbred Strains; Vanadates | 1989 |
Induction of intestinal glucose carriers in streptozocin-treated chronically diabetic rats.
Topics: 3-O-Methylglucose; Animals; Autoradiography; Biological Transport; Diabetes Mellitus, Experimental; Glucose; Ileum; Intestinal Absorption; Male; Methylglucosides; Methylglycosides; Microvilli; Phlorhizin; Rats; Rats, Inbred Lew; Streptozocin | 1989 |
Phlorizin-induced normoglycemia partially restores glucoregulation in diabetic dogs.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Dogs; Dopamine; Epinephrine; Female; Glucagon; Homeostasis; Insulin; Kinetics; Male; Norepinephrine; Phlorhizin; Reference Values | 1989 |
Phlorizin-induced glycosuria does not prevent gentamicin nephrotoxicity in rats.
Topics: Acute Kidney Injury; Animals; Diabetes Mellitus, Experimental; Female; Gentamicins; Glycosuria; Kidney; Kidney Cortex; Phlorhizin; Rats; Rats, Inbred Strains | 1989 |
Relationship of glucagon suppression by insulin and somatostatin to the ambient glucose concentration.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Dogs; Glucagon; Insulin; Phlorhizin; Somatostatin | 1987 |
Intestinal adaptation to diabetes. Altered Na-dependent nutrient absorption in streptozocin-treated chronically diabetic rats.
Topics: 3-O-Methylglucose; Alanine; Animals; Carrier Proteins; Diabetes Mellitus, Experimental; Hydroxydopamines; Ileum; Intestinal Absorption; Jejunum; Kinetics; Male; Methylglucosides; Microvilli; Oxidopamine; Phlorhizin; Rats; Rats, Inbred Lew; Sodium; Streptozocin; Sulfates; Sympathectomy, Chemical | 1987 |
Sodium-hydrogen exchange and glucose transport in renal microvillus membrane vesicles from rats with diabetes mellitus.
Topics: Acid-Base Equilibrium; Animals; Autoimmune Diseases; Biological Transport; Carrier Proteins; Diabetes Mellitus, Experimental; Glucose; In Vitro Techniques; Kidney; Microvilli; Phlorhizin; Rats; Sodium; Sodium-Hydrogen Exchangers; Temperature | 1986 |
Changes in glucose uptake by and phlorizin binding to brush-border membrane vesicles of small intestine from streptozotocin-induced diabetic rats.
Topics: Animals; Biological Transport; Diabetes Mellitus, Experimental; Glucose; Intestine, Small; Kinetics; Male; Microvilli; Monosaccharide Transport Proteins; Phlorhizin; Rats; Rats, Inbred Strains; Sodium; Sucrase | 1988 |
Effect of chronic hyperglycemia on in vivo insulin secretion in partially pancreatectomized rats.
Topics: Animals; Arginine; Blood Glucose; Body Weight; Chronic Disease; Diabetes Mellitus, Experimental; Glycosuria; Hyperglycemia; Insulin; Insulin Secretion; Islets of Langerhans; Male; Pancreas; Pancreatectomy; Phlorhizin; Rats; Rats, Inbred Strains | 1987 |
Antecedent chronic hyperglycaemia blocks phlorizin-induced insulin resistance in the dog.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Dogs; Glucagon; Glycosuria; Hyperglycemia; Insulin Resistance; Kidney; Male; Phlorhizin | 1988 |
Glucoregulation in alloxan-diabetic dogs.
Topics: Animals; Blood Glucose; Catecholamines; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Dogs; Glucagon; Humans; Insulin; Liver; Phlorhizin | 1986 |
Influence of insulin on urinary eicosanoid excretion in rats with experimental diabetes mellitus.
Topics: Animals; Blood Pressure; Diabetes Mellitus, Experimental; Insulin; Kallikreins; Male; Phlorhizin; Prostaglandins; Rats; Rats, Inbred Strains; Thromboxanes | 1986 |
Correction of hyperglycemia with phlorizin normalizes tissue sensitivity to insulin in diabetic rats.
Topics: Animals; Diabetes Mellitus, Experimental; Glycosuria; Hyperglycemia; Hyperinsulinism; Insulin Resistance; Male; Phlorhizin; Rats; Rats, Inbred Strains | 1987 |
Relation between microvilli membrane potential and glucose transport capacity of rat small intestine.
Topics: Animals; Biological Transport; Cell Membrane; Diabetes Mellitus, Experimental; Epithelium; Female; Glucose; In Vitro Techniques; Intestine, Small; Male; Membrane Potentials; Microelectrodes; Microvilli; Phlorhizin; Rats; Rats, Inbred Strains; Time Factors | 1987 |
Correction of hyperglycemia with phloridzin restores the glucagon response to glucose in insulin-deficient dogs: implications for human diabetes.
Topics: Animals; Diabetes Mellitus, Experimental; Dogs; Glucagon; Glucose; Hyperglycemia; Islets of Langerhans; Phlorhizin | 1985 |
Effects of fasting, diabetes and glucocorticoids on gluconeogenic enzymes in the sheep.
Topics: Aldehyde-Lyases; Animals; Blood Glucose; Carboxy-Lyases; Cortisone; Dexamethasone; Diabetes Mellitus; Diabetes Mellitus, Experimental; Fasting; Female; Gluconeogenesis; Glucose-6-Phosphatase; Ketone Bodies; Kidney; Ligases; Liver; Pancreas; Pancreatectomy; Phlorhizin; Pregnancy; Rats; Sheep; Species Specificity | 1969 |
Some properties and possible physiological functions of phosphotransferase activities of microsomal glucose-6-phosphatase.
Topics: Alcohols; Amino Acids; Animals; Bicarbonates; Bile Acids and Salts; Carbohydrates; Citric Acid Cycle; Detergents; Diabetes Mellitus, Experimental; Fasting; Glucocorticoids; Glucose-6-Phosphatase; Glycogen; Glycolysis; Hexosephosphates; Hydrogen-Ion Concentration; In Vitro Techniques; Insulin; Intestine, Small; Kidney; Lipids; Microsomes; Microsomes, Liver; Nucleotides; Phlorhizin | 1969 |
Microsomal acetylesterase activity in tumor-bearing rats.
Topics: Acetylesterase; Animals; Carcinoma, Hepatocellular; Diabetes Mellitus, Experimental; Fasting; Hydrocortisone; Liver Neoplasms; Male; Microsomes, Liver; Neoplasms, Experimental; Phlorhizin; Protein Deficiency; Rats | 1974 |
Testosterone and sugar transport in levator ani muscle of rat.
Topics: Adrenal Cortex Hormones; Adrenalectomy; Animals; Biological Transport; Carbon Isotopes; Cyanides; Diabetes Mellitus, Experimental; Glucose; Hypophysectomy; Insulin; Kinetics; Male; Muscle Denervation; Muscles; Oxygen; Pancreatic Juice; Phlorhizin; Pituitary Hormones, Anterior; Pituitary Hormones, Posterior; Rats; Testosterone; Xylose | 1969 |
Distribution of glucose and related metabolites in rat kidney.
Topics: Adenosine Triphosphate; Animals; Chlorothiazide; Diabetes Mellitus, Experimental; Glucose; Glycogen; Hexosephosphates; Insulin; Ischemia; Kidney; Lactates; Male; Organomercury Compounds; Phlorhizin; Phosphocreatine; Rats; Starvation | 1968 |
Transport and metabolism of glucose, insulin sensitivity and lipolysis of epididymal adipose tissue of alloxan-diabetic rats after prolonged incubation in vitro.
Topics: Adipose Tissue; Animals; Biological Transport; Carbon Isotopes; Culture Techniques; Cycloheximide; Dactinomycin; Diabetes Mellitus, Experimental; Epididymis; Fatty Acids; Fructose; Glucose; Glycerol; Glycogen; Lipid Metabolism; Male; Phlorhizin; Rats | 1968 |
The role of glucokinase in the phosphorylation of glucose by rat liver.
Topics: Animals; Cortisone; Diabetes Mellitus, Experimental; Glucokinase; Glucose; Hexokinase; Hexosephosphates; In Vitro Techniques; Insulin; Liver; Phlorhizin; Rats; Starvation | 1964 |
Relationship of ketone body metabolism and carbohydrate utilization to fat mobilization in the ruminant.
Topics: Animals; Blood Glucose; Cattle; Diabetes Mellitus, Experimental; Dietary Carbohydrates; Fats; Fatty Acids; Fatty Acids, Nonesterified; Goats; Hydroxybutyrates; Ketone Bodies; Phlorhizin; Tolbutamide | 1966 |