phloretin has been researched along with Inflammation in 24 studies
Inflammation: A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Phloretin and its glycoside phlorizin have been reported to prevent obesity induced by high-fat diet (HFD), but the effect of 3-OH phloretin, a catechol metabolite of phloretin, has not been investigated." | 8.31 | 3-OH Phloretin Inhibits High-Fat Diet-Induced Obesity and Obesity-Induced Inflammation by Reducing Macrophage Infiltration into White Adipose Tissue. ( Cao, NT; Choi, H; Jang, J; Kang, HS; Nguyen, NA; Seon, JE; Woo, SM; Yee, SM; Yun, CH, 2023) |
| "7 cells stimulated with LPS (1μg/mL) and in in-vivo study, colitis was induced by intra rectal administration of 4% Acetic acid." | 8.02 | Phloretin Ameliorates Acetic Acid Induced Colitis Through Modulation of Immune and Inflammatory Reactions in Rats. ( S K, K; V S, A, 2021) |
| " The effects of phloretin on renal function, fibrosis, oxidative stress, inflammation, and UA metabolism in HUA mice were evaluated." | 7.96 | Phloretin ameliorates hyperuricemia-induced chronic renal dysfunction through inhibiting NLRP3 inflammasome and uric acid reabsorption. ( Chen, Y; Cheng, J; Cui, D; Li, L; Liu, J; Liu, S; Lu, Y; Mao, R; Tang, M; Wang, C; Yuan, Y; Zhao, M, 2020) |
| "Phloretin pretreatment reduced the LPS-induced release of IL-6 and IL-8 as well as VEGF." | 5.91 | Phloretin inhibits glucose transport and reduces inflammation in human retinal pigment epithelial cells. ( Bhattarai, N; Hytti, M; Kanerva, I; Kauppinen, A; Nielsen, CU; Pedersen, ML; Ruuth, J, 2023) |
| "Nonalcoholic fatty liver disease (NAFLD) with growing incidences is a major health concern worldwide." | 5.72 | Phloretin mitigates oxidative injury, inflammation, and fibrogenic responses via restoration of autophagic flux in in vitro and preclinical models of NAFLD. ( Chhimwal, J; Goel, A; Padwad, Y; Patial, V; Sukapaka, M, 2022) |
| "The phloretin-MGO adducts were analyzed in PBS and HUVECs." | 5.51 | Phloretin and its methylglyoxal adduct: Implications against advanced glycation end products-induced inflammation in endothelial cells. ( Gong, J; Wang, M; Zhou, Q, 2019) |
| "Phloretin is a naturally occurring dietary flavonoid that is abundant in fruit." | 5.48 | Phloretin as a Potent Natural TLR2/1 Inhibitor Suppresses TLR2-Induced Inflammation. ( Durai, P; Jeon, D; Jung, ID; Kim, J; Kim, Y; Lee, SJ; Park, YM, 2018) |
| "Phloretin treatment significantly attenuated the inflammatory response in macrophage cells (J774) co-cultured with S." | 5.48 | Phloretin reduces cell injury and inflammation mediated by Staphylococcus aureus via targeting sortase B and the molecular mechanism. ( Gao, Y; Niu, X; Wang, G; Wang, H; Wang, J, 2018) |
| "Hyperuricemia is an important risk factor for cardiovascular and renal diseases." | 5.46 | Phloretin attenuates hyperuricemia-induced endothelial dysfunction through co-inhibiting inflammation and GLUT9-mediated uric acid uptake. ( Chen, Y; Cheng, J; Liu, J; Liu, S; Lu, Y; Yuan, Y; Zhao, M; Zhou, Y, 2017) |
| "Phloretin treatment significantly blocks high-fat diet-induced weight gain but did not induce weight loss in obese animals." | 5.46 | Phloretin Prevents High-Fat Diet-Induced Obesity and Improves Metabolic Homeostasis. ( Alsanea, S; Gao, M; Liu, D, 2017) |
| "Phloretin and its glycoside phlorizin have been reported to prevent obesity induced by high-fat diet (HFD), but the effect of 3-OH phloretin, a catechol metabolite of phloretin, has not been investigated." | 4.31 | 3-OH Phloretin Inhibits High-Fat Diet-Induced Obesity and Obesity-Induced Inflammation by Reducing Macrophage Infiltration into White Adipose Tissue. ( Cao, NT; Choi, H; Jang, J; Kang, HS; Nguyen, NA; Seon, JE; Woo, SM; Yee, SM; Yun, CH, 2023) |
| "7 cells stimulated with LPS (1μg/mL) and in in-vivo study, colitis was induced by intra rectal administration of 4% Acetic acid." | 4.02 | Phloretin Ameliorates Acetic Acid Induced Colitis Through Modulation of Immune and Inflammatory Reactions in Rats. ( S K, K; V S, A, 2021) |
| " The effects of phloretin on renal function, fibrosis, oxidative stress, inflammation, and UA metabolism in HUA mice were evaluated." | 3.96 | Phloretin ameliorates hyperuricemia-induced chronic renal dysfunction through inhibiting NLRP3 inflammasome and uric acid reabsorption. ( Chen, Y; Cheng, J; Cui, D; Li, L; Liu, J; Liu, S; Lu, Y; Mao, R; Tang, M; Wang, C; Yuan, Y; Zhao, M, 2020) |
| " The aim was to investigate and compare the effect of docosahexaenoic acid (DHA) ester of PZ (PZ-DHA) and its parent compounds (phloridzin and DHA), phloretin (the aglycone of PZ) and cyclooxygenase inhibitory drugs (diclofenac and nimesulide) on production of pro-inflammatory biomarkers in inflammation-induced macrophages by lipopolysaccharide (LPS)-stimulation." | 3.81 | Docosahexaenoic acid ester of phloridzin inhibit lipopolysaccharide-induced inflammation in THP-1 differentiated macrophages. ( Rupasinghe, HP; Sekhon-Loodu, S, 2015) |
| "Phloretin pretreatment reduced the LPS-induced release of IL-6 and IL-8 as well as VEGF." | 1.91 | Phloretin inhibits glucose transport and reduces inflammation in human retinal pigment epithelial cells. ( Bhattarai, N; Hytti, M; Kanerva, I; Kauppinen, A; Nielsen, CU; Pedersen, ML; Ruuth, J, 2023) |
| "Nonalcoholic fatty liver disease (NAFLD) with growing incidences is a major health concern worldwide." | 1.72 | Phloretin mitigates oxidative injury, inflammation, and fibrogenic responses via restoration of autophagic flux in in vitro and preclinical models of NAFLD. ( Chhimwal, J; Goel, A; Padwad, Y; Patial, V; Sukapaka, M, 2022) |
| "The phloretin-MGO adducts were analyzed in PBS and HUVECs." | 1.51 | Phloretin and its methylglyoxal adduct: Implications against advanced glycation end products-induced inflammation in endothelial cells. ( Gong, J; Wang, M; Zhou, Q, 2019) |
| "Neuroinflammation is one of the significant neuropathological conditions in Parkinson's disease (PD) which is due to microglial and astrocytes activation leads to progressive dopaminergic neuronal loss." | 1.51 | Phloretin attenuates behavior deficits and neuroinflammatory response in MPTP induced Parkinson's disease in mice. ( Liu, J; Yang, G; Zhang, G, 2019) |
| "Phloretin is a naturally occurring dietary flavonoid that is abundant in fruit." | 1.48 | Phloretin as a Potent Natural TLR2/1 Inhibitor Suppresses TLR2-Induced Inflammation. ( Durai, P; Jeon, D; Jung, ID; Kim, J; Kim, Y; Lee, SJ; Park, YM, 2018) |
| "Phloretin treatment significantly attenuated the inflammatory response in macrophage cells (J774) co-cultured with S." | 1.48 | Phloretin reduces cell injury and inflammation mediated by Staphylococcus aureus via targeting sortase B and the molecular mechanism. ( Gao, Y; Niu, X; Wang, G; Wang, H; Wang, J, 2018) |
| "Hyperuricemia is an important risk factor for cardiovascular and renal diseases." | 1.46 | Phloretin attenuates hyperuricemia-induced endothelial dysfunction through co-inhibiting inflammation and GLUT9-mediated uric acid uptake. ( Chen, Y; Cheng, J; Liu, J; Liu, S; Lu, Y; Yuan, Y; Zhao, M; Zhou, Y, 2017) |
| "Phloretin treatment significantly blocks high-fat diet-induced weight gain but did not induce weight loss in obese animals." | 1.46 | Phloretin Prevents High-Fat Diet-Induced Obesity and Improves Metabolic Homeostasis. ( Alsanea, S; Gao, M; Liu, D, 2017) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (4.17) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (4.17) | 29.6817 |
| 2010's | 14 (58.33) | 24.3611 |
| 2020's | 8 (33.33) | 2.80 |
| Authors | Studies |
|---|---|
| Saunders, MJ | 1 |
| Edwards, BS | 1 |
| Zhu, J | 1 |
| Sklar, LA | 1 |
| Graves, SW | 1 |
| Chhimwal, J | 1 |
| Goel, A | 1 |
| Sukapaka, M | 1 |
| Patial, V | 1 |
| Padwad, Y | 1 |
| Wang, K | 1 |
| Lei, Q | 1 |
| Ma, H | 1 |
| Jiang, M | 1 |
| Yang, T | 1 |
| Ma, Q | 1 |
| Datsomor, O | 1 |
| Zhan, K | 1 |
| Zhao, G | 1 |
| Hytti, M | 1 |
| Ruuth, J | 1 |
| Kanerva, I | 1 |
| Bhattarai, N | 1 |
| Pedersen, ML | 1 |
| Nielsen, CU | 1 |
| Kauppinen, A | 1 |
| Woo, SM | 1 |
| Nguyen, NA | 1 |
| Seon, JE | 1 |
| Jang, J | 1 |
| Yee, SM | 1 |
| Cao, NT | 1 |
| Choi, H | 1 |
| Yun, CH | 1 |
| Kang, HS | 1 |
| Cui, D | 1 |
| Liu, S | 2 |
| Tang, M | 1 |
| Lu, Y | 3 |
| Zhao, M | 2 |
| Mao, R | 1 |
| Wang, C | 1 |
| Yuan, Y | 2 |
| Li, L | 1 |
| Chen, Y | 2 |
| Cheng, J | 2 |
| Liu, J | 3 |
| Chauhan, A | 1 |
| Jang, M | 1 |
| Kim, Y | 2 |
| V S, A | 1 |
| S K, K | 1 |
| Un, H | 1 |
| Ugan, RA | 1 |
| Gurbuz, MA | 1 |
| Bayir, Y | 1 |
| Kahramanlar, A | 1 |
| Kaya, G | 1 |
| Cadirci, E | 1 |
| Halici, Z | 1 |
| Zhou, Y | 1 |
| Kim, J | 1 |
| Durai, P | 1 |
| Jeon, D | 1 |
| Jung, ID | 1 |
| Lee, SJ | 1 |
| Park, YM | 1 |
| Wang, G | 1 |
| Gao, Y | 1 |
| Wang, H | 1 |
| Wang, J | 1 |
| Niu, X | 1 |
| Mariadoss, AVA | 1 |
| Vinyagam, R | 1 |
| Rajamanickam, V | 1 |
| Sankaran, V | 1 |
| Venkatesan, S | 1 |
| David, E | 1 |
| Zhou, Q | 1 |
| Gong, J | 1 |
| Wang, M | 1 |
| Ying, Y | 1 |
| Jiang, C | 1 |
| Zhang, M | 1 |
| Jin, J | 1 |
| Ge, S | 1 |
| Wang, X | 1 |
| Zielinska, D | 1 |
| Laparra-Llopis, JM | 1 |
| Zielinski, H | 1 |
| Szawara-Nowak, D | 1 |
| Giménez-Bastida, JA | 1 |
| Zhang, G | 1 |
| Yang, G | 1 |
| Huang, WC | 2 |
| Chang, WT | 2 |
| Wu, SJ | 1 |
| Xu, PY | 1 |
| Ting, NC | 1 |
| Liou, CJ | 2 |
| Fordham, JB | 1 |
| Naqvi, AR | 1 |
| Nares, S | 1 |
| Sekhon-Loodu, S | 1 |
| Rupasinghe, HP | 1 |
| Alsanea, S | 1 |
| Gao, M | 1 |
| Liu, D | 1 |
| Jung, M | 1 |
| Triebel, S | 1 |
| Anke, T | 1 |
| Richling, E | 1 |
| Erkel, G | 1 |
| Sanner, JH | 1 |
2 reviews available for phloretin and Inflammation
| Article | Year |
|---|---|
Pharmacological Aspects and Potential Use of Phloretin: A Systemic Review.
Topics: Antineoplastic Agents; Antioxidants; Arthritis, Rheumatoid; Cardiovascular Diseases; Diabetes Mellit | 2019 |
Substances that inhibit the actions of prostaglandins.
Topics: Abortion, Therapeutic; Analgesics; Anemia, Sickle Cell; Animals; Anti-Inflammatory Agents; Bone Reso | 1974 |
22 other studies available for phloretin and Inflammation
| Article | Year |
|---|---|
Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
Topics: Animals; Biotinylation; Flow Cytometry; Fluorescence Resonance Energy Transfer; Green Fluorescent Pr | 2010 |
Phloretin mitigates oxidative injury, inflammation, and fibrogenic responses via restoration of autophagic flux in in vitro and preclinical models of NAFLD.
Topics: Animals; Autophagy; Diet, High-Fat; Fatty Acids; Inflammation; Liver; Mice; Mice, Inbred C57BL; Non- | 2022 |
Phloretin Protects Bovine Rumen Epithelial Cells from LPS-Induced Injury.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Cattle; Chemokines; Epithelial Cells; Female; Infla | 2022 |
Phloretin inhibits glucose transport and reduces inflammation in human retinal pigment epithelial cells.
Topics: Epithelial Cells; Glucose; Humans; Inflammation; Interleukin-6; Interleukin-8; Lipopolysaccharides; | 2023 |
3-OH Phloretin Inhibits High-Fat Diet-Induced Obesity and Obesity-Induced Inflammation by Reducing Macrophage Infiltration into White Adipose Tissue.
Topics: Adipose Tissue; Adipose Tissue, White; Animals; Diet, High-Fat; Inflammation; Insulin Resistance; Ma | 2023 |
Phloretin ameliorates hyperuricemia-induced chronic renal dysfunction through inhibiting NLRP3 inflammasome and uric acid reabsorption.
Topics: Animals; Cell Line; Cytokines; Fibrosis; Humans; Hyperuricemia; Inflammasomes; Inflammation; Kidney | 2020 |
Phloretin Protects Macrophages from
Topics: Animals; Escherichia coli; Inflammation; Macrophages; Mice; NF-kappa B; Nitric Oxide; Phloretin; RAW | 2020 |
Phloretin Ameliorates Acetic Acid Induced Colitis Through Modulation of Immune and Inflammatory Reactions in Rats.
Topics: Acetic Acid; Animals; Colitis; Colon; Immunity; Inflammation; Mice; Phloretin; Rats; Rats, Wistar; R | 2021 |
Phloretin and phloridzin guard against cisplatin-induced nephrotoxicity in mice through inhibiting oxidative stress and inflammation.
Topics: Animals; Antineoplastic Agents; Cisplatin; Female; Gene Expression Regulation; Inflammation; Kidney | 2021 |
Phloretin attenuates hyperuricemia-induced endothelial dysfunction through co-inhibiting inflammation and GLUT9-mediated uric acid uptake.
Topics: Cell Adhesion; Cell Line, Tumor; Cells, Cultured; Endothelium, Vascular; Glucose Transport Proteins, | 2017 |
Phloretin as a Potent Natural TLR2/1 Inhibitor Suppresses TLR2-Induced Inflammation.
Topics: Animals; Anti-Inflammatory Agents; Dose-Response Relationship, Drug; HEK293 Cells; Humans; Inflammat | 2018 |
Phloretin reduces cell injury and inflammation mediated by Staphylococcus aureus via targeting sortase B and the molecular mechanism.
Topics: Aminoacyltransferases; Anti-Bacterial Agents; Bacterial Adhesion; Bacterial Proteins; Binding Sites; | 2018 |
Phloretin and its methylglyoxal adduct: Implications against advanced glycation end products-induced inflammation in endothelial cells.
Topics: Cell-Free System; Endothelium, Vascular; Glycation End Products, Advanced; Human Umbilical Vein Endo | 2019 |
Phloretin protects against cardiac damage and remodeling via restoring SIRT1 and anti-inflammatory effects in the streptozotocin-induced diabetic mouse model.
Topics: Animals; Cell Line; Diabetes Mellitus, Experimental; Diabetic Cardiomyopathies; Fibrosis; Gene Expre | 2019 |
Role of Apple Phytochemicals, Phloretin and Phloridzin, in Modulating Processes Related to Intestinal Inflammation.
Topics: Anti-Inflammatory Agents; Cell Line; Colon; Diet; Dinoprostone; Fruit; Glycation End Products, Advan | 2019 |
Phloretin attenuates behavior deficits and neuroinflammatory response in MPTP induced Parkinson's disease in mice.
Topics: Animals; Behavior, Animal; Calcium-Binding Proteins; Cyclooxygenase 2; Cytokines; Disease Models, An | 2019 |
Phloretin and phlorizin promote lipolysis and inhibit inflammation in mouse 3T3-L1 cells and in macrophage-adipocyte co-cultures.
Topics: 3T3-L1 Cells; Adipocytes; Adipogenesis; AMP-Activated Protein Kinases; Animals; Anti-Obesity Agents; | 2013 |
Leukocyte production of inflammatory mediators is inhibited by the antioxidants phloretin, silymarin, hesperetin, and resveratrol.
Topics: Aggregatibacter actinomycetemcomitans; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Cell D | 2014 |
Docosahexaenoic acid ester of phloridzin inhibit lipopolysaccharide-induced inflammation in THP-1 differentiated macrophages.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Cell Differentiation; Cell Line; Cyclooxygenase Inhibitors; | 2015 |
Phloretin Prevents High-Fat Diet-Induced Obesity and Improves Metabolic Homeostasis.
Topics: Adipose Tissue, White; Adiposity; Animals; Antioxidants; Diet, High-Fat; Drug Evaluation, Preclinica | 2017 |
Influence of apple polyphenols on inflammatory gene expression.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Biflavonoids; Catechin; Cell Line, Tumor; Cytokines; Flavon | 2009 |
Evaluation of the anti-inflammatory effects of phloretin and phlorizin in lipopolysaccharide-stimulated mouse macrophages.
Topics: Animals; Anti-Inflammatory Agents; Cell Line; Cytokines; Humans; Inflammation; Interleukin-6; Lipopo | 2012 |