phloretin has been researched along with Disease Models, Animal in 18 studies
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Male Wistar albino rats were randomly divided into three groups: sham group, CLP induced sepsis group and phloretin treated CLP group." | 7.83 | Effects of phloretin on oxidative and inflammatory reaction in rat model of cecal ligation and puncture induced sepsis. ( Aliomrani, M; Kazemi, AR; Mirzaei, HR; Nekonam, S; Sabzevari, O; Sepand, MR, 2016) |
| " Here, we investigated the effects of phloretin on platelet-derived growth factor homodimer (PDGF-BB)-induced rat aortic smooth muscle cell (RASMC) proliferation, migration, and neointimal formation after carotid injury." | 7.81 | Phloretin Inhibits Platelet-derived Growth Factor-BB-induced Rat Aortic Smooth Muscle Cell Proliferation, Migration, and Neointimal Formation After Carotid Injury. ( Qiao, Y; Tang, C; Wang, D; Wang, Q; Yan, G, 2015) |
| " Mice were pretreated with low or high dosage of PHL for 7 days via intragastric administration once a day before LPS injection." | 5.72 | The inhibition of GLUT1-induced glycolysis in macrophage by phloretin participates in the protection during acute lung injury. ( Li, W; Song, T; Songyang, Y; Yang, J, 2022) |
| "Human triple-negative breast cancer (TNBC) is the most aggressive and poorly understood subclass of breast cancer." | 5.48 | The apple polyphenol phloretin inhibits breast cancer cell migration and proliferation via inhibition of signals by type 2 glucose transporter. ( Chen, LC; Chen, ZF; Ho, CT; Ho, YS; Lin, TN; Whang-Peng, J; Wu, KH, 2018) |
| "Male Wistar albino rats were randomly divided into three groups: sham group, CLP induced sepsis group and phloretin treated CLP group." | 3.83 | Effects of phloretin on oxidative and inflammatory reaction in rat model of cecal ligation and puncture induced sepsis. ( Aliomrani, M; Kazemi, AR; Mirzaei, HR; Nekonam, S; Sabzevari, O; Sepand, MR, 2016) |
| " Here, we investigated the effects of phloretin on platelet-derived growth factor homodimer (PDGF-BB)-induced rat aortic smooth muscle cell (RASMC) proliferation, migration, and neointimal formation after carotid injury." | 3.81 | Phloretin Inhibits Platelet-derived Growth Factor-BB-induced Rat Aortic Smooth Muscle Cell Proliferation, Migration, and Neointimal Formation After Carotid Injury. ( Qiao, Y; Tang, C; Wang, D; Wang, Q; Yan, G, 2015) |
| " Mice were pretreated with low or high dosage of PHL for 7 days via intragastric administration once a day before LPS injection." | 1.72 | The inhibition of GLUT1-induced glycolysis in macrophage by phloretin participates in the protection during acute lung injury. ( Li, W; Song, T; Songyang, Y; Yang, J, 2022) |
| "Neuroinflammation is one of the significant neuropathological conditions in Parkinson's disease (PD) which is due to microglial and astrocytes activation leads to progressive dopaminergic neuronal loss." | 1.51 | Phloretin attenuates behavior deficits and neuroinflammatory response in MPTP induced Parkinson's disease in mice. ( Liu, J; Yang, G; Zhang, G, 2019) |
| "Phloretin pretreatment dramatically suppressed the mucins secretion, inflammatory cell infiltration and inflammatory cytokine release in mouse lungs induced by CS, and it also suppressed CSE-induced expression of MUC5AC and IL-1β in NCI-H292 bronchial epithelial cells." | 1.48 | Phloretin attenuates mucus hypersecretion and airway inflammation induced by cigarette smoke. ( Chen, L; Hao, N; Shen, Y; Wang, H; Wang, T; Wen, F; Wu, Y; Yang, T; Yuan, Z, 2018) |
| "Human triple-negative breast cancer (TNBC) is the most aggressive and poorly understood subclass of breast cancer." | 1.48 | The apple polyphenol phloretin inhibits breast cancer cell migration and proliferation via inhibition of signals by type 2 glucose transporter. ( Chen, LC; Chen, ZF; Ho, CT; Ho, YS; Lin, TN; Whang-Peng, J; Wu, KH, 2018) |
| "Osteoporosis is one of the most prevalent forms of age-related bone diseases." | 1.46 | Dietary phlorizin enhances osteoblastogenic bone formation through enhancing β-catenin activity via GSK-3β inhibition in a model of senile osteoporosis. ( Antika, LD; Choi, YJ; Kang, MK; Kang, YH; Kim, DY; Kim, YH; Lee, EJ; Oh, H; Park, SH, 2017) |
| "Phloretin was effective in preventing estrogen deficiency-induced osteoclastogenic resorption." | 1.40 | Phloretin promotes osteoclast apoptosis in murine macrophages and inhibits estrogen deficiency-induced osteoporosis in mice. ( Gong, JH; Kang, MK; Kang, YH; Kim, JL; Kim, YH; Lee, EJ, 2014) |
| "Chronic renal failure (CRF) is associated with increased cardiovascular mortality, and medial vascular smooth muscle cell (VSMC) hypertrophy, proliferation, and calcification play a pivotal role in uremic vasculopathy." | 1.39 | Enhanced expression of glucose transporter-1 in vascular smooth muscle cells via the Akt/tuberous sclerosis complex subunit 2 (TSC2)/mammalian target of rapamycin (mTOR)/ribosomal S6 protein kinase (S6K) pathway in experimental renal failure. ( Hsu, SC; Hsu, YJ; Huang, SM; Lee, HS; Lin, CY; Lin, SH; Shih, CC; Tsai, CS, 2013) |
| "Uremic rats in chronic renal failure were gavaged daily with 25 microM 2'-PP." | 1.32 | Effect of 2'-phosphophloretin on renal function in chronic renal failure rats. ( Clarke, RD; Peerce, BE; Weaver, L, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (5.56) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (5.56) | 29.6817 |
| 2010's | 13 (72.22) | 24.3611 |
| 2020's | 3 (16.67) | 2.80 |
| Authors | Studies |
|---|---|
| Solinski, HJ | 1 |
| Dranchak, P | 1 |
| Oliphant, E | 1 |
| Gu, X | 1 |
| Earnest, TW | 1 |
| Braisted, J | 1 |
| Inglese, J | 1 |
| Hoon, MA | 1 |
| Abrams, RPM | 1 |
| Yasgar, A | 1 |
| Teramoto, T | 1 |
| Lee, MH | 1 |
| Dorjsuren, D | 1 |
| Eastman, RT | 1 |
| Malik, N | 1 |
| Zakharov, AV | 1 |
| Li, W | 3 |
| Bachani, M | 1 |
| Brimacombe, K | 1 |
| Steiner, JP | 1 |
| Hall, MD | 1 |
| Balasubramanian, A | 1 |
| Jadhav, A | 1 |
| Padmanabhan, R | 1 |
| Simeonov, A | 1 |
| Nath, A | 1 |
| Songyang, Y | 1 |
| Yang, J | 1 |
| Song, T | 1 |
| Chang, CK | 1 |
| Chiu, PF | 1 |
| Yang, HY | 1 |
| Juang, YP | 1 |
| Lai, YH | 1 |
| Lin, TS | 1 |
| Hsu, LC | 1 |
| Yu, LC | 1 |
| Liang, PH | 1 |
| Antika, LD | 1 |
| Lee, EJ | 2 |
| Kim, YH | 2 |
| Kang, MK | 2 |
| Park, SH | 1 |
| Kim, DY | 1 |
| Oh, H | 1 |
| Choi, YJ | 1 |
| Kang, YH | 2 |
| Wang, H | 1 |
| Yang, T | 1 |
| Wang, T | 1 |
| Hao, N | 1 |
| Shen, Y | 1 |
| Wu, Y | 1 |
| Yuan, Z | 1 |
| Chen, L | 1 |
| Wen, F | 1 |
| Wu, KH | 1 |
| Ho, CT | 1 |
| Chen, ZF | 1 |
| Chen, LC | 1 |
| Whang-Peng, J | 1 |
| Lin, TN | 1 |
| Ho, YS | 1 |
| Ghumatkar, PJ | 1 |
| Patil, SP | 1 |
| Peshattiwar, V | 1 |
| Vijaykumar, T | 1 |
| Dighe, V | 1 |
| Vanage, G | 1 |
| Sathaye, S | 1 |
| Zhang, G | 1 |
| Yang, G | 1 |
| Liu, J | 1 |
| Kim, JL | 1 |
| Gong, JH | 1 |
| Liu, Y | 1 |
| Zhang, L | 1 |
| Liang, J | 1 |
| Wang, D | 1 |
| Wang, Q | 1 |
| Yan, G | 1 |
| Qiao, Y | 1 |
| Tang, C | 1 |
| Abkin, SV | 1 |
| Ostroumova, OS | 1 |
| Komarova, EY | 1 |
| Meshalkina, DA | 1 |
| Shevtsov, MA | 1 |
| Margulis, BA | 1 |
| Guzhova, IV | 1 |
| Aliomrani, M | 1 |
| Sepand, MR | 1 |
| Mirzaei, HR | 1 |
| Kazemi, AR | 1 |
| Nekonam, S | 1 |
| Sabzevari, O | 1 |
| Wang, J | 1 |
| Liu, B | 1 |
| Teng, Z | 1 |
| Zhou, X | 1 |
| Wang, X | 1 |
| Zhang, B | 1 |
| Lu, G | 1 |
| Niu, X | 1 |
| Yang, Y | 1 |
| Deng, X | 1 |
| Lin, CY | 1 |
| Hsu, SC | 1 |
| Lee, HS | 1 |
| Lin, SH | 1 |
| Tsai, CS | 1 |
| Huang, SM | 1 |
| Shih, CC | 1 |
| Hsu, YJ | 1 |
| Peerce, BE | 1 |
| Weaver, L | 1 |
| Clarke, RD | 1 |
| Wiley, JS | 1 |
| Clarke, D | 1 |
| Hutchinson, JS | 1 |
| Doyle, AE | 1 |
18 other studies available for phloretin and Disease Models, Animal
| Article | Year |
|---|---|
Inhibition of natriuretic peptide receptor 1 reduces itch in mice.
Topics: Animals; Behavior, Animal; Cell-Free System; Dermatitis, Contact; Disease Models, Animal; Ganglia, S | 2019 |
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Dr | 2020 |
The inhibition of GLUT1-induced glycolysis in macrophage by phloretin participates in the protection during acute lung injury.
Topics: Acute Lung Injury; Animals; Disease Models, Animal; Glucose Transporter Type 1; Glycolysis; Lipopoly | 2022 |
Targeting Colorectal Cancer with Conjugates of a Glucose Transporter Inhibitor and 5-Fluorouracil.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Survival; Colorectal Neoplasms; Disease Model | 2021 |
Dietary phlorizin enhances osteoblastogenic bone formation through enhancing β-catenin activity via GSK-3β inhibition in a model of senile osteoporosis.
Topics: Animals; beta Catenin; Biomarkers; Bone and Bones; Bone Density; Bone Density Conservation Agents; C | 2017 |
Phloretin attenuates mucus hypersecretion and airway inflammation induced by cigarette smoke.
Topics: Animals; Anti-Inflammatory Agents; Cell Line; Cigarette Smoking; Disease Models, Animal; ErbB Recept | 2018 |
The apple polyphenol phloretin inhibits breast cancer cell migration and proliferation via inhibition of signals by type 2 glucose transporter.
Topics: Animals; Antineoplastic Agents, Phytogenic; Breast Neoplasms; Cell Cycle Checkpoints; Cell Line, Tum | 2018 |
The modulatory role of phloretin in Aβ
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Behavior, Animal; Brain; Disease Models, Animal; | 2019 |
Phloretin attenuates behavior deficits and neuroinflammatory response in MPTP induced Parkinson's disease in mice.
Topics: Animals; Behavior, Animal; Calcium-Binding Proteins; Cyclooxygenase 2; Cytokines; Disease Models, An | 2019 |
Phloretin promotes osteoclast apoptosis in murine macrophages and inhibits estrogen deficiency-induced osteoporosis in mice.
Topics: Animals; Apoptosis; Bone Resorption; Cell Differentiation; Cell Line, Tumor; Disease Models, Animal; | 2014 |
Activation of the Nrf2 defense pathway contributes to neuroprotective effects of phloretin on oxidative stress injury after cerebral ischemia/reperfusion in rats.
Topics: Animals; Brain Ischemia; Disease Models, Animal; Male; Metabolic Networks and Pathways; Neuroprotect | 2015 |
Phloretin Inhibits Platelet-derived Growth Factor-BB-induced Rat Aortic Smooth Muscle Cell Proliferation, Migration, and Neointimal Formation After Carotid Injury.
Topics: Animals; Aorta, Thoracic; Becaplermin; Carotid Arteries; Carotid Artery Injuries; Cell Adhesion Mole | 2015 |
Phloretin increases the anti-tumor efficacy of intratumorally delivered heat-shock protein 70 kDa (HSP70) in a murine model of melanoma.
Topics: Animals; Cell Line, Tumor; Disease Models, Animal; Female; HSP70 Heat-Shock Proteins; Humans; Immuno | 2016 |
Effects of phloretin on oxidative and inflammatory reaction in rat model of cecal ligation and puncture induced sepsis.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Blood Urea Nitrogen; Disease Models, Animal; Gene E | 2016 |
Phloretin Attenuates
Topics: Aminoacyltransferases; Animals; Anti-Bacterial Agents; Bacterial Load; Bacterial Proteins; Bacterial | 2017 |
Enhanced expression of glucose transporter-1 in vascular smooth muscle cells via the Akt/tuberous sclerosis complex subunit 2 (TSC2)/mammalian target of rapamycin (mTOR)/ribosomal S6 protein kinase (S6K) pathway in experimental renal failure.
Topics: Animals; Aorta; Apoptosis; Blotting, Western; Cell Line; Cell Proliferation; Cyclin D1; Cyclin-Depen | 2013 |
Effect of 2'-phosphophloretin on renal function in chronic renal failure rats.
Topics: Animals; Disease Models, Animal; Kidney Failure, Chronic; Male; Nephrectomy; Osmolar Concentration; | 2004 |
Factors affecting the sodium permeability of rat erythrocytes.
Topics: Animals; Cell Membrane Permeability; Disease Models, Animal; Erythrocytes; Female; Hypertension; Lit | 1981 |