pheophorbide-a has been researched along with Hemolysis* in 3 studies
3 other study(ies) available for pheophorbide-a and Hemolysis
| Article | Year |
|---|---|
Trehangelins A, B and C, novel photo-oxidative hemolysis inhibitors produced by an endophytic actinomycete, Polymorphospora rubra K07-0510.
Three new natural products, designated trehangelins A, B and C, were isolated by solvent extraction, silica gel and octadecylsilyl silica gel column chromatographies and subsequent preparative HPLC from the cultured broth of an endophytic actinomycete strain, Polymorphospora rubra K07-0510. The trehangelins consisted of a trehalose moiety and two angelic acid moieties. Trehangelins A (IC50 value, 0.1 mg ml(-1)) and C (IC50 value, 0.4 mg ml(-1)), with symmetric structures, showed potent inhibitory activity against hemolysis of red blood cells induced by light-activated pheophorbide a. However, trehangelin B, with an asymmetric structure, displayed only a slight inhibition (IC50 value, 1.0 mg ml(-1)). Topics: Actinobacteria; Biological Products; Cell Survival; Chemical Phenomena; Chlorophyll; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Endophytes; Erythrocytes; HEK293 Cells; Hemolysis; HT29 Cells; Humans; Inhibitory Concentration 50; Molecular Conformation; Orchidaceae; Oxidative Stress; Plant Roots; Radiation-Protective Agents; Radiation-Sensitizing Agents; Trehalose | 2013 |
Mechanism of photosensitization by pheophorbide alpha studied by photohemolysis of erythrocytes and electron spin resonance spectroscopy.
Topics: Animals; Chlorophyll; Electron Spin Resonance Spectroscopy; Erythrocytes; Goats; Hemolysis; In Vitro Techniques; Photolysis; Radiation-Sensitizing Agents | 1989 |
Preventive effects of L-ascorbic acid and calcium pantothenate against photosensitive actions induced by pheophorbide alpha and hematoporphyrin.
The preventive effects of L-ascorbic acid (V.C) and pantothenic acid (PaA) against photosensitized hemolysis in the presence of pheophorbide a or hematoporphyrin were investigated in vitro. The development of hematoporphyrin-induced photosensitivity and the preventive effects of V.C and PaA were also investigated in male mice. V.C and PaA exerted preventive effects against photosensitized hemolysis in the presence of pheophorbide a or hematoporphyrin. In such cases, V.C and PaA had not only an additive effect but also a synergistic one. The time required for the photosensitized acute shock-like death (i.e., survival time), was significantly extended by simultaneous administration of V.C and PaA. This supports the findings of in vitro experiments. Topics: Animals; Ascorbic Acid; Chlorophyll; Drug Synergism; Hematoporphyrins; Hemolysis; Light; Male; Mice; Pantothenic Acid; Photosensitivity Disorders; Rats | 1981 |