phenytoin has been researched along with Uremia in 74 studies
Uremia: A clinical syndrome associated with the retention of renal waste products or uremic toxins in the blood. It is usually the result of RENAL INSUFFICIENCY. Most uremic toxins are end products of protein or nitrogen CATABOLISM, such as UREA or CREATININE. Severe uremia can lead to multiple organ dysfunctions with a constellation of symptoms.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Patients with uremia are reported to have elevated concentrations of free phenytoin as a result of decreases in protein binding." | 7.68 | Increased free phenytoin concentrations in predialysis serum compared to postdialysis serum in patients with uremia treated with hemodialysis. Role of uremic compounds. ( Abu-Alfa, A; Dasgupta, A, 1992) |
| "A 25-year-old man with sickle cell disease and chronic renal insufficiency had tonic-clonic seizures treated with phenytoin." | 7.67 | Interpretation of serum phenytoin concentrations in uremia is assay-dependent. ( Green, PJ; Rocci, ML; Sirgo, MA; Vlasses, PH, 1984) |
| "A major endogenous ligand substance, 3-carboxy-4-methyl-5-propyl-2-furanpropanoic acid (CMPF), accumulated in the sera of uremic patients, inhibited phenytoin binding to pooled serum obtained from healthy subjects and to human serum albumin in a concentration usually observed in the sera of patients with uremia." | 7.67 | A major inhibitor of phenytoin binding to serum protein in uremia. ( Mabuchi, H; Nakahashi, H, 1988) |
| "Free phenytoin levels were determined in ultrafiltrates (MPS-1; Amicon, Lexington, MA, U." | 5.27 | Temperature dependence of phenytoin-protein binding in serum: effects of uremia and hypoalbuminemia. ( Allison, TB; Comstock, TJ, 1988) |
| "The measurement of the unbound or free phenytoin concentration is indicated in several situations, including uremia." | 3.71 | Performance characteristics of four free phenytoin immunoassays. ( Annesley, TM; De, BK; Juenke, JM; Moulton, L; Moyer, TP; Roberts, WL, 2001) |
| "Accumulation of phenytoin metabolites in uremia has been shown to interfere with some immunoassay methods for phenytoin measurement." | 3.68 | Interference in immunoassay measurements of total and free phenytoin in uremic patients: a reappraisal. ( Rainey, PM; Roberts, WL, 1993) |
| "A 25-year-old man with sickle cell disease and chronic renal insufficiency had tonic-clonic seizures treated with phenytoin." | 3.67 | Interpretation of serum phenytoin concentrations in uremia is assay-dependent. ( Green, PJ; Rocci, ML; Sirgo, MA; Vlasses, PH, 1984) |
| "A computer program for phenytoin (PHT) dosing was developed containing seven different menus: two for drug-naive patients, one using an empirical equation, the other using means for Vmax and Km; two for patients in whom either one or two dose rates and steady-state concentrations are available; two for patients with hypoalbuminemia, and uremia, respectively; and one menu that optimizes Vmax and Km from available steady-state concentrations." | 3.67 | Evaluation of a phenytoin dosage regimen design and adjustment computer program. ( Alcorn, GJ; Fogelson, MH; Johnson, RD; Rao, S; Ritschel, WA, 1989) |
| "A major endogenous ligand substance, 3-carboxy-4-methyl-5-propyl-2-furanpropanoic acid (CMPF), accumulated in the sera of uremic patients, inhibited phenytoin binding to pooled serum obtained from healthy subjects and to human serum albumin in a concentration usually observed in the sera of patients with uremia." | 3.67 | A major inhibitor of phenytoin binding to serum protein in uremia. ( Mabuchi, H; Nakahashi, H, 1988) |
| "The aim of the present investigation is to study digitoxin and digoxin protein binding in patients with normal renal and hepatic function, in patients with uremia, and in patients under treatment with hemodialysis for renal failure." | 3.65 | Studies on digitalis. V. The influence of impaired renal function, hemodialysis, and drug interaction on serum protein binding of digitoxin and digoxin. ( Storstein, L, 1976) |
| "Phenytoin assays were evaluated using an additional set of samples from patients with abnormal renal function." | 1.31 | Performance characteristics of four immunoassays for antiepileptic drugs on the IMMULITE 2000 automated analyzer. ( Annesley, TM; Frank, EL; Juenke, J; Roberts, WL; Schwarz, EL, 2002) |
| "Seizures were treated successfully with intravenous phenytoin, and muromonab-CD3 administration was discontinued." | 1.30 | Generalized seizures associated with the use of muromonab-CD3 in two patients after kidney transplantation. ( Lawrence, KR; Monaco, AP; Rahamtulla, AF; Seifeldin, RA, 1997) |
| "Fosphenytoin is a new phosphate ester prodrug of phenytoin." | 1.30 | Elevated free fosphenytoin concentrations in uremic sera: uremic toxins hippuric acid and indoxyl sulfate do not account for the impaired protein binding of fosphenytoin. ( Dasgupta, A; Havlik, D, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 61 (82.43) | 18.7374 |
| 1990's | 7 (9.46) | 18.2507 |
| 2000's | 6 (8.11) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Frank, EL | 1 |
| Schwarz, EL | 1 |
| Juenke, J | 1 |
| Annesley, TM | 3 |
| Roberts, WL | 5 |
| Reiter, K | 1 |
| Bordoni, V | 1 |
| Dall'Olio, G | 1 |
| Ricatti, MG | 1 |
| Soli, M | 1 |
| Ruperti, S | 1 |
| Soffiati, G | 1 |
| Galloni, E | 1 |
| D'Intini, V | 1 |
| Bellomo, R | 1 |
| Ronco, C | 1 |
| Van Peer, AP | 2 |
| Belpaire, FM | 2 |
| Bogaert, MG | 2 |
| Sawchuk, RJ | 2 |
| Matzke, GR | 2 |
| Sirgo, MA | 1 |
| Green, PJ | 2 |
| Rocci, ML | 2 |
| Vlasses, PH | 2 |
| Gulyassy, PF | 3 |
| Bottini, AT | 1 |
| Jarrard, EA | 2 |
| Stanfel, LA | 2 |
| Argyle, JC | 1 |
| Kinniburgh, DW | 2 |
| Costa, R | 1 |
| Jennison, T | 1 |
| Tiula, E | 2 |
| Frauenhoffer, SM | 1 |
| Hennessey, KM | 1 |
| Flachs, H | 1 |
| Rasmussen, JM | 1 |
| Burgess, ED | 1 |
| Friel, PN | 1 |
| Blair, AD | 1 |
| Raisys, VA | 1 |
| Aldwin, L | 2 |
| Kabakoff, DS | 2 |
| Depner, TA | 2 |
| Fichtl, B | 1 |
| Gerdsmeier, W | 1 |
| Boyd, ND | 1 |
| Lynn, K | 1 |
| Braithwaite, R | 1 |
| Dawling, S | 1 |
| Rosser, R | 1 |
| Dasgupta, A | 5 |
| Malik, S | 1 |
| Rainey, PM | 2 |
| Timmerman, TG | 1 |
| Rogers, KE | 1 |
| Seifeldin, RA | 1 |
| Lawrence, KR | 1 |
| Rahamtulla, AF | 1 |
| Monaco, AP | 1 |
| Havlik, D | 1 |
| Biddle, DA | 1 |
| Wells, A | 1 |
| De, BK | 1 |
| Moulton, L | 1 |
| Juenke, JM | 1 |
| Moyer, TP | 1 |
| Kurzyniec, S | 1 |
| Nordblom, GD | 1 |
| Buchanan, N | 1 |
| Pool, W | 1 |
| Reily, M | 1 |
| Talaat, R | 1 |
| Dager, WE | 1 |
| Porter, RJ | 1 |
| Layzer, RB | 1 |
| Adler, DS | 3 |
| Martin, E | 2 |
| Gambertoglio, JG | 2 |
| Tozer, TN | 2 |
| Roman, LA | 1 |
| Grausz, H | 1 |
| Storstein, L | 1 |
| Olsen, GD | 1 |
| Bennett, WM | 1 |
| Porter, GA | 1 |
| Reidenberg, MM | 4 |
| Raskin, NH | 1 |
| Fishman, RA | 1 |
| Borga, O | 6 |
| Cederlof, I | 1 |
| Spire, JP | 1 |
| Bosl, R | 1 |
| Shideman, JR | 1 |
| Meyer, RM | 1 |
| Buselmeier, TJ | 1 |
| von Hartitzsch, B | 1 |
| Kjellstrand, CM | 1 |
| Livingston, S | 1 |
| Berman, W | 1 |
| Pauli, LL | 1 |
| Ehrnebo, M | 1 |
| Odar-Cederlöf, I | 5 |
| L'Estrange Orme, M | 1 |
| Cook, CE | 1 |
| Sjöqvist, F | 5 |
| Craig, WA | 1 |
| Evenson, MA | 1 |
| Sarver, KP | 1 |
| Wagnild, JP | 1 |
| Abu-Alfa, A | 1 |
| Mabuchi, H | 3 |
| Nakahashi, H | 3 |
| Hamajima, T | 1 |
| Aikawa, I | 1 |
| Oka, T | 1 |
| Ritschel, WA | 1 |
| Alcorn, GJ | 1 |
| Johnson, RD | 1 |
| Rao, S | 1 |
| Fogelson, MH | 1 |
| Allison, TB | 1 |
| Comstock, TJ | 1 |
| Vanholder, R | 1 |
| Van Landschoot, N | 1 |
| De Smet, R | 1 |
| Schoots, A | 1 |
| Ringoir, S | 1 |
| Pugh, CB | 1 |
| Golper, TA | 1 |
| Saad, AM | 1 |
| Reeves, SE | 1 |
| Hanyok, JJ | 1 |
| Amon, SA | 1 |
| Godley, PJ | 1 |
| Koike, Y | 1 |
| Magnusson, A | 1 |
| Steiner, E | 1 |
| Rane, A | 2 |
| Neuvonen, PJ | 1 |
| Lunde, P | 1 |
| Hildick-Smith, M | 1 |
| von Bahr, C | 1 |
| Affrime, M | 1 |
| Shoeman, DW | 2 |
| Benjamin, DM | 1 |
| Azarnoff, DL | 2 |
| Eadie, MJ | 1 |
| Tyrer, JH | 1 |
| Hooper, WD | 1 |
| Kurata, D | 1 |
| Wilkinson, GR | 1 |
| Hansotia, P | 1 |
| Keran, E | 1 |
| Lund, L | 1 |
| Lunde, PK | 1 |
| Markkanen, T | 1 |
| Peltola, O | 1 |
| Blum, MR | 1 |
| Riegelman, S | 1 |
| Becker, CE | 1 |
| Desjacques, P | 1 |
| Lunde, KM | 1 |
| Letteri, JM | 1 |
| Mellk, H | 1 |
| Louis, S | 1 |
| Kutt, H | 1 |
| Durante, P | 1 |
| Glazko, A | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Cytokine Adsorption in Severe, Refractory Septic Shock[NCT04910893] | 48 participants (Actual) | Interventional | 2014-11-27 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for phenytoin and Uremia
| Article | Year |
|---|---|
Drug metabolism in uremia.
Topics: Acetohexamide; Animals; Antipyrine; Humans; Hydrolysis; Lipid Metabolism; Microsomes, Liver; Oxidati | 1975 |
Neurologic disorders in renal failure (first of two parts).
Topics: Blood-Brain Barrier; Brain Diseases; Cerebrospinal Fluid Proteins; Diazepam; Epilepsy; Humans; Lidoc | 1976 |
Effect of disease states on plasma protein binding of drugs.
Topics: Blood Proteins; Blood Urea Nitrogen; Creatinine; Dapsone; Digitoxin; Drug Interactions; Humans; Hypo | 1974 |
71 other studies available for phenytoin and Uremia
| Article | Year |
|---|---|
Performance characteristics of four immunoassays for antiepileptic drugs on the IMMULITE 2000 automated analyzer.
Topics: Anticonvulsants; Carbamazepine; Chromatography, High Pressure Liquid; Cross Reactions; Drug Monitori | 2002 |
In vitro removal of therapeutic drugs with a novel adsorbent system.
Topics: Adsorption; Anti-Bacterial Agents; Biocompatible Materials; Carbamazepine; Digoxin; Glycopeptides; H | 2002 |
In vitro hepatic oxidative metabolism of antipyrine, phenytoin and phenylbutazone in uraemic rabbits.
Topics: Animals; Antipyrine; Female; In Vitro Techniques; Kinetics; Liver; Microsomes, Liver; Oxidation-Redu | 1980 |
Contribution of 5-(4-hydroxyphenyl)-5-phenylhydantoin to the discrepancy between phenytoin analyses by EMIT and high-pressure liquid chromatography.
Topics: Chromatography, High Pressure Liquid; Humans; Immunoenzyme Techniques; Phenytoin; Plasma; Uremia | 1984 |
Interpretation of serum phenytoin concentrations in uremia is assay-dependent.
Topics: Adult; Chromatography, High Pressure Liquid; Humans; Immunoassay; Male; Phenytoin; Seizures; Uremia | 1984 |
Isolation of inhibitors of ligand: albumin-binding from uremic body fluids and normal urine.
Topics: Chromatography, High Pressure Liquid; Chromatography, Ion Exchange; Humans; Phenylacetates; Phenylpr | 1983 |
Evaluation of an ultrafiltration-fluorescence polarization immunoassay for monitoring unbound phenytoin.
Topics: Blood Protein Disorders; Fluorescence Polarization; Humans; Immunoassay; Phenytoin; Ultrafiltration; | 1984 |
A pressure ultrafiltration method for serum free drug determination. Comparison with equilibrium dialysis using normal and uraemic sera.
Topics: Dialysis; Humans; Pharmaceutical Preparations; Phenytoin; Temperature; Ultrafiltration; Uremia | 1984 |
Phenytoin can be measured reliably in uremic patients by immunoassay.
Topics: Humans; Immunoassay; Methods; Phenytoin; Uremia | 1983 |
Renal disease may increase apparent phenytoin in serum as measured by enzyme-multiplied immunoassay.
Topics: Humans; Immunoenzyme Techniques; Phenytoin; Uremia | 1980 |
Serum phenytoin concentrations in uremia.
Topics: Chromatography, Gas; Chromatography, High Pressure Liquid; Humans; Immunoenzyme Techniques; Kidney; | 1981 |
Metabolite interference in homogeneous enzyme immunoassay of phenytoin.
Topics: Glucuronates; Humans; Immunoenzyme Techniques; Phenytoin; Uremia | 1981 |
Elevated serum phenytoin concentrations in a uremic patient when measured by enzyme-multiplied immunoassay.
Topics: Female; Humans; Immunoenzyme Techniques; Middle Aged; Phenytoin; Uremia | 1981 |
Serum phenytoin concentrations in uremia.
Topics: Cross Reactions; Humans; Immunoenzyme Techniques; Phenytoin; Uremia | 1981 |
Plasma protein binding in uremia: extraction and characterization of an inhibitor.
Topics: Animals; Anion Exchange Resins; Binding, Competitive; Blood Proteins; Cattle; Horses; Humans; Phenyt | 1980 |
Increased plasma protein binding of propranolol in rabbits with acute renal failure.
Topics: Acute Kidney Injury; Animals; Blood Proteins; Creatinine; Female; Glycerol; Male; Phenytoin; Propran | 1981 |
Isolation of peptides from uremic plasma that inhibit phenytoin binding to normal plasma proteins.
Topics: Adsorption; Blood Proteins; Charcoal; Humans; In Vitro Techniques; Peptides; Phenytoin; Protein Bind | 1981 |
Impaired plasma phenytoin binding in uremia. Effect of in vitro acidification and anion-exchange resin.
Topics: Albumins; Anion Exchange Resins; Binding, Competitive; Humans; Hydrogen-Ion Concentration; Kidney Fa | 1980 |
Comparison of the serum protein binding of maprotiline and phenytoin in uraemic patients on haemodialysis.
Topics: Adolescent; Adult; Aged; Anthracenes; Blood Proteins; Female; Humans; Male; Maprotiline; Middle Aged | 1981 |
Fast atom bombardment mass spectrometric determination of the molecular weight range of uremic compounds that displace phenytoin from protein binding: absence of midmolecular uremic toxins.
Topics: Drug Interactions; Guanidine; Guanidines; Hippurates; Humans; In Vitro Techniques; Indican; Methylgu | 1994 |
Interference in immunoassay measurements of total and free phenytoin in uremic patients: a reappraisal.
Topics: Adult; Aged; Aged, 80 and over; Chromatography, High Pressure Liquid; Creatinine; Enzyme Multiplied | 1993 |
In vitro displacement of phenytoin from protein binding by nonsteroidal antiinflammatory drugs tolmetin, ibuprofen, and naproxen in normal and uremic sera.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Blood Proteins; Humans; Ibuprofen; Naproxen; Phenytoin; Pro | 1996 |
Metabolite and matrix interference in phenytoin immunoassays.
Topics: Calibration; Enzyme Multiplied Immunoassay Technique; Fluorescence Polarization; Humans; Immunoassay | 1996 |
Generalized seizures associated with the use of muromonab-CD3 in two patients after kidney transplantation.
Topics: Adult; Anticonvulsants; Female; Humans; Immunosuppressive Agents; Kidney Transplantation; Kidney Tub | 1997 |
Elevated free fosphenytoin concentrations in uremic sera: uremic toxins hippuric acid and indoxyl sulfate do not account for the impaired protein binding of fosphenytoin.
Topics: Anticonvulsants; Drug Interactions; Fluorescence Polarization Immunoassay; Hippurates; Humans; Indic | 1998 |
Unexpected suppression of free phenytoin concentration by salicylate in uremic sera due to the presence of inhibitors: MALDI mass spectrometric determination of molecular weight range of inhibitors.
Topics: Anticonvulsants; Binding, Competitive; Charcoal; Creatinine; Drug Interactions; Gas Chromatography-M | 2000 |
Performance characteristics of four free phenytoin immunoassays.
Topics: Anticonvulsants; Chromatography, High Pressure Liquid; Humans; Immunoassay; Phenytoin; Uremia | 2001 |
Glucuronidation of prodrug reactive site: isolation and characterization of oxymethylglucuronide metabolite of fosphenytoin.
Topics: Chromatography, High Pressure Liquid; Deuterium; Fluorescence Polarization Immunoassay; Glucuronides | 2001 |
Phenytoin assay errors in uremia.
Topics: Adult; Aged; Chromatography, High Pressure Liquid; Creatinine; Fluorescence Polarization Immunoassay | 2002 |
Plasma albumin concentration and diphenylhydantoin binding in man.
Topics: Adolescent; Adult; Aged; Aspirin; Blood Protein Electrophoresis; Blood-Brain Barrier; Chromatography | 1975 |
Use of plasma concentration determinations: phenytoin.
Topics: Blood Proteins; Humans; Kinetics; Phenytoin; Protein Binding; Renal Dialysis; Uremia | 1979 |
Removal of phenytoin by hemodialysis in uremic patients.
Topics: Adolescent; Adult; Epilepsy; Female; Half-Life; Humans; Male; Middle Aged; Phenytoin; Plasma; Renal | 1977 |
Distribution of phenytoin and phenylbutazone in normal and uraemic rabbits.
Topics: Animals; Phenylbutazone; Phenytoin; Rabbits; Tissue Distribution; Uremia | 1978 |
Studies on digitalis. V. The influence of impaired renal function, hemodialysis, and drug interaction on serum protein binding of digitoxin and digoxin.
Topics: Blood Proteins; Digitoxin; Digoxin; Drug Interactions; Heparin; Humans; Kidney; Kidney Transplantati | 1976 |
Morphine and phenytoin binding to plasma proteins in renal and hepatic failure.
Topics: Bilirubin; Blood Proteins; Creatinine; Humans; Jaundice; Kidney Failure, Chronic; Kidney Transplanta | 1975 |
Proceedings: Plasma protein binding and kinetics of diphenylhydantoin in uraemic patients.
Topics: Humans; Phenytoin; Protein Binding; Serum Albumin; Uremia | 1974 |
Hemodialysis of phenytoin in a uremic patient.
Topics: Adult; Blood Proteins; Creatinine; Humans; Male; Phenytoin; Protein Binding; Renal Dialysis; Seizure | 1975 |
Effects and complications of high efficiency dialysis.
Topics: Barbiturates; Blood Urea Nitrogen; Body Weight; Calcium; Creatinine; Edema; Headache; Humans; Hypote | 1975 |
Anticonvulsant drug blood levels.
Topics: Anticonvulsants; Ataxia; Diplopia; Drug Therapy, Combination; Epilepsy; Humans; Nystagmus, Pathologi | 1975 |
Binding of amobarbital, pentobarbital and diphenylhydantoin to blood cells and plasma proteins in healthy volunteers and uraemic patients.
Topics: Adult; Aged; Amobarbital; Blood Proteins; Creatinine; Erythrocytes; Humans; In Vitro Techniques; Mid | 1975 |
Measurement of diphenylhydantoin in 0.1-ml plasma samples: gas chromatography and radioimmunoassay compared.
Topics: Child; Chromatography, Gas; Evaluation Studies as Topic; Humans; Phenytoin; Radioimmunoassay; Time F | 1976 |
Correction of protein binding defect in uremic sera by charcoal treatment.
Topics: Blood Proteins; Charcoal; Dicloxacillin; Digitoxin; Fatty Acids, Nonesterified; Humans; In Vitro Tec | 1976 |
Impaired plasma protein binding of phenytoin in uremia and displacement effect of salicylic acid.
Topics: Adult; Aged; Binding, Competitive; Blood Proteins; Female; Humans; Kinetics; Male; Middle Aged; Phen | 1976 |
Increased free phenytoin concentrations in predialysis serum compared to postdialysis serum in patients with uremia treated with hemodialysis. Role of uremic compounds.
Topics: Adsorption; Charcoal; Humans; Phenytoin; Regression Analysis; Renal Dialysis; Uremia | 1992 |
The effect of renal transplantation on a major endogenous ligand retained in uremic serum.
Topics: Adult; Chromatography, High Pressure Liquid; Furans; Humans; Indoleacetic Acids; Kidney Transplantat | 1989 |
Evaluation of a phenytoin dosage regimen design and adjustment computer program.
Topics: Adolescent; Adult; Child; Child, Preschool; Female; Humans; Infant; Male; Phenytoin; Protein Binding | 1989 |
Temperature dependence of phenytoin-protein binding in serum: effects of uremia and hypoalbuminemia.
Topics: Humans; Phenytoin; Protein Binding; Serum Albumin; Temperature; Uremia | 1988 |
A major inhibitor of phenytoin binding to serum protein in uremia.
Topics: Adult; Binding, Competitive; Furans; Humans; In Vitro Techniques; Male; Middle Aged; Phenytoin; Prop | 1988 |
Drug protein binding in chronic renal failure: evaluation of nine drugs.
Topics: Blood Proteins; Chromatography, High Pressure Liquid; Humans; Kidney Failure, Chronic; Pharmaceutica | 1988 |
Phenytoin and phenobarbital protein binding alterations in a uremic burn patient.
Topics: Burns; Humans; Male; Middle Aged; Phenobarbital; Phenytoin; Protein Binding; Seizures; Serum Albumin | 1987 |
Isolation and characterization of an endogenous drug-binding inhibitor present in uremic serum.
Topics: Furans; Gas Chromatography-Mass Spectrometry; Humans; Ligands; Phenytoin; Propionates; Protein Bindi | 1986 |
Gentamicin and phenytoin sieving through hollow-fiber polysulfone hemofilters.
Topics: Blood; Blood Flow Velocity; Blood Proteins; Gentamicins; Humans; Mathematics; Phenytoin; Polymers; P | 1986 |
Discrepancy in serum phenytoin concentrations determined by two immunoassay methods in uremic patients.
Topics: Adult; Autoanalysis; Female; Humans; Immunoenzyme Techniques; Male; Middle Aged; Phenytoin; Uremia | 1985 |
Ultrafiltration compared with equilibrium dialysis in the determination of unbound phenytoin in plasma.
Topics: Blood Proteins; Dialysis; Epilepsy; Humans; Immunoenzyme Techniques; Phenytoin; Protein Binding; Ult | 1985 |
Effect of total drug concentration on the free fraction in uremic sera.
Topics: Adult; Aged; Creatinine; Diazepam; Female; Humans; Male; Middle Aged; Orosomucoid; Pharmaceutical Pr | 1986 |
Abnormal pharmacokinetics of phenytoin in a patient with uraemia.
Topics: Epilepsy; Humans; Male; Middle Aged; Phenytoin; Uremia | 1970 |
Epilepsy in the elderly.
Topics: Age Factors; Aged; Angiography; Brain Neoplasms; Cerebrovascular Disorders; Dementia; Electroencepha | 1974 |
Protein binding of diphenylhydantoin and desmethylimipramine in plasma from patients with poor renal function.
Topics: Adult; Aged; Blood Proteins; Blood Urea Nitrogen; Desipramine; Humans; Middle Aged; Phenytoin; Prote | 1971 |
Influence of disease on binding of drugs to plasma proteins.
Topics: Arrhythmias, Cardiac; Arteriosclerosis; Blood Proteins; Blood Urea Nitrogen; Carbon Radioisotopes; C | 1973 |
The alteration of plasma proteins in uremia as reflected in the ability to bind diphenylhydantoin.
Topics: Ammonium Sulfate; Blood Protein Electrophoresis; Blood Proteins; Dialysis; Electrophoresis, Disc; Hu | 1973 |
Diphenylhydantoin dosage.
Topics: Adolescent; Adult; Age Factors; Body Weight; Child; Chromatography, Gas; Drug Interactions; Epilepsy | 1973 |
Erythrocyte uptake and plasma binding of diphenylhydantoin.
Topics: Carbon Radioisotopes; Dialysis; Erythrocytes; Ethosuximide; Female; Hematocrit; Humans; Hydroxylatio | 1974 |
Kinetics of diphenylhydantoin in uraemic patients: consequences of decreased plasma protein binding.
Topics: Adult; Aged; Blood Proteins; Carbon Radioisotopes; Chromatography, Gas; Creatinine; Female; Half-Lif | 1974 |
Diphenylhydantoin binding by red blood cells of normal subjects.
Topics: Cell Membrane; Erythrocytes; Humans; Phenytoin; Protein Binding; Uremia | 1974 |
Plasma protein binding, plasma concentrations, and effects of diphenylhydantoin in man.
Topics: Blood; Blood Proteins; Epilepsy; Epilepsy, Tonic-Clonic; Female; Humans; Hyperbilirubinemia; In Vitr | 1971 |
Pentose-phosphate pathway of leucocytes.
Topics: Adult; Aged; Alcoholism; Anemia, Aplastic; Arthritis, Rheumatoid; Asthma; Diabetes Mellitus; Female; | 1971 |
Altered protein binding of diphenylhydantoin in uremic plasma.
Topics: Binding Sites; Blood Proteins; Half-Life; Humans; Phenytoin; Protein Binding; Uremia | 1972 |
[The diffusion of diphenylhydantoin across the cellophane membrane of the artificial kidney in a patient with uremia and epilepsy].
Topics: Cellophane; Diffusion; Epilepsy; Humans; Kidney Diseases, Cystic; Kidney Failure, Chronic; Kidneys, | 1972 |
The alteration of plasma proteins in uremia as reflected in their ability to bind digitoxin and diphenylhydantoin.
Topics: Ammonium Sulfate; Blood Proteins; Chemical Precipitation; Creatinine; Dialysis; Digitoxin; Electroph | 1972 |
Plasma protein binding of diphenylhydantoin in man.
Topics: Adult; Aspirin; Bilirubin; Blood Proteins; Carbon Isotopes; Epilepsy; Female; Humans; Hydrogen-Ion C | 1971 |
Diphenylhydantoin metabolism in uremia.
Topics: Administration, Oral; Adult; Female; Humans; Injections, Intravenous; Kidney Failure, Chronic; Male; | 1971 |