phenytoin has been researched along with Tuberculosis, Meningeal in 7 studies
Tuberculosis, Meningeal: A form of bacterial meningitis caused by MYCOBACTERIUM TUBERCULOSIS or rarely MYCOBACTERIUM BOVIS. The organism seeds the meninges and forms microtuberculomas which subsequently rupture. The clinical course tends to be subacute, with progressions occurring over a period of several days or longer. Headache and meningeal irritation may be followed by SEIZURES, cranial neuropathies, focal neurologic deficits, somnolence, and eventually COMA. The illness may occur in immunocompetent individuals or as an OPPORTUNISTIC INFECTION in the ACQUIRED IMMUNODEFICIENCY SYNDROME and other immunodeficiency syndromes. (From Adams et al., Principles of Neurology, 6th ed, pp717-9)
| Excerpt | Relevance | Reference |
|---|---|---|
| " The aim of the study is to evaluate the effect of simultaneously administered isoniazid (300 mg/day) and phenytoin (300 mg/day) on 60 patients with tuberculous meningitis or tuberculoma having seizures." | 9.17 | Phenotypic interaction of simultaneously administered isoniazid and phenytoin in patients with tuberculous meningitis or tuberculoma having seizures. ( Adole, PS; Kharbanda, PS; Sharma, S; Singh, A, 2013) |
| "Simultaneous administration of phenytoin and isoniazid (INH) in tuberculous meningitis (TBM) or tuberculoma patients with seizures results in higher plasma phenytoin level and thus phenytoin intoxication." | 7.83 | N-acetyltransferase 2 (NAT2) gene polymorphism as a predisposing factor for phenytoin intoxication in tuberculous meningitis or tuberculoma patients having seizures - A pilot study. ( Adole, PS; Kharbanda, PS; Sharma, S, 2016) |
| " The aim of the study is to evaluate the effect of simultaneously administered isoniazid (300 mg/day) and phenytoin (300 mg/day) on 60 patients with tuberculous meningitis or tuberculoma having seizures." | 5.17 | Phenotypic interaction of simultaneously administered isoniazid and phenytoin in patients with tuberculous meningitis or tuberculoma having seizures. ( Adole, PS; Kharbanda, PS; Sharma, S; Singh, A, 2013) |
| "Simultaneous administration of phenytoin and isoniazid (INH) in tuberculous meningitis (TBM) or tuberculoma patients with seizures results in higher plasma phenytoin level and thus phenytoin intoxication." | 3.83 | N-acetyltransferase 2 (NAT2) gene polymorphism as a predisposing factor for phenytoin intoxication in tuberculous meningitis or tuberculoma patients having seizures - A pilot study. ( Adole, PS; Kharbanda, PS; Sharma, S, 2016) |
| "Cerebellar changes have been reported in relationship to epilepsy alone as well as to phenytoin therapy for the control of seizures." | 3.65 | Phenytoin-related cerebellar degeneration without seizures. ( Rapport, RL; Shaw, CM, 1977) |
| " Although clinicians are aware of the interaction with two widely used antituberculosis agents, rifampin and isoniazid, few reports have described the implications for managing phenytoin dosing in this situation." | 1.39 | Phenytoin-rifampin drug interaction in a hypoalbuminemic, renal failure patient: a complex clinical case. ( Hurdle, AC; Twilla, JD; Van Berkel, MA, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (28.57) | 18.7374 |
| 1990's | 1 (14.29) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 4 (57.14) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Van Berkel, MA | 1 |
| Hurdle, AC | 1 |
| Twilla, JD | 1 |
| Adole, PS | 2 |
| Singh, A | 1 |
| Kharbanda, PS | 2 |
| Sharma, S | 2 |
| Baidya, DK | 1 |
| Trikha, A | 1 |
| Menon, S | 1 |
| Garg, R | 1 |
| Olson, WA | 1 |
| Pruitt, AW | 1 |
| Dayton, PG | 1 |
| Kelly, JJ | 1 |
| Horowitz, EA | 1 |
| Destache, CJ | 1 |
| Fruin, AH | 1 |
| Long, VA | 1 |
| Rapport, RL | 1 |
| Shaw, CM | 1 |
1 trial available for phenytoin and Tuberculosis, Meningeal
| Article | Year |
|---|---|
Phenotypic interaction of simultaneously administered isoniazid and phenytoin in patients with tuberculous meningitis or tuberculoma having seizures.
Topics: Acetylation; Adult; Drug Interactions; Female; Humans; Isoniazid; Male; Phenotype; Phenytoin; Seizur | 2013 |
6 other studies available for phenytoin and Tuberculosis, Meningeal
| Article | Year |
|---|---|
Phenytoin-rifampin drug interaction in a hypoalbuminemic, renal failure patient: a complex clinical case.
Topics: Acute Kidney Injury; Anticonvulsants; Antitubercular Agents; Dose-Response Relationship, Drug; Drug | 2013 |
N-acetyltransferase 2 (NAT2) gene polymorphism as a predisposing factor for phenytoin intoxication in tuberculous meningitis or tuberculoma patients having seizures - A pilot study.
Topics: Acetylation; Adult; Arylamine N-Acetyltransferase; Drug Combinations; Drug-Related Side Effects and | 2016 |
Anaesthetic management of emergency caesarean section in a patient with seizures and likely raised intracranial pressure due to tuberculous meningitis.
Topics: Adult; Androstanols; Anesthesia, Obstetrical; Anesthetics, Inhalation; Anesthetics, Intravenous; Ant | 2011 |
Plasma concentrations of isoniazid in children with tuberculous infections.
Topics: Administration, Oral; Adolescent; Adult; Child; Child, Preschool; Drug Therapy, Combination; Female; | 1981 |
Diagnosis and treatment of complicated tubercular meningitis.
Topics: Adult; Aminoglycosides; Anti-Bacterial Agents; Anticonvulsants; Female; Humans; Mycobacterium tuberc | 1999 |
Phenytoin-related cerebellar degeneration without seizures.
Topics: Cerebellum; Epilepsy; Female; Gliosis; Humans; Isoniazid; Middle Aged; Nerve Degeneration; Neuroglia | 1977 |