phenytoin has been researched along with Thrombocytopenia in 34 studies
Thrombocytopenia: A subnormal level of BLOOD PLATELETS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To describe a patient with severe thrombocytopenia induced by the administration of phenytoin for prevention of seizures." | 7.69 | Phenytoin-induced thrombocytopenia. ( Holtzer, CD; Reisner-Keller, LA, 1997) |
| "Combined use of cimetidine and phenytoin among 1512 neurosurgical patients has led to severe thrombocytopenia in 4 patients." | 7.67 | Severe thrombocytopenia due to combined cimetidine and phenytoin therapy. ( Chan, KH; Mann, KS; Yue, CP, 1987) |
| "A 67-year-old man developed a sudden onset of severe isolated thrombocytopenia (platelet count, 1000/mm3) after 10 days of phenytoin administration as a prophylactic measure prior to craniotomy." | 7.67 | Severe thrombocytopenia associated with phenytoin and cimetidine therapy. ( Brown, FD; Lichtor, T; Wong, YY, 1985) |
| "Sudden, severe thrombocytopenia developed in each of three patients receiving diphenylhydantion, diazepam, and sulfisoxazole, respectively." | 7.65 | Detection of drug-dependent antibodies by the 51Cr platelet lysis test: documentation of immune thrombocytopenia induced by diphenylhydantoin, diazepam, and sulfisoxazole. ( Aster, RH; Cimo, PL; Desai, RG; Pino, JL; Pisciotta, AV, 1977) |
| "Severe thrombocytopenia was managed first by transfusion of 17 units of platelets and by cessation of intravenous phenytoin plus the starting of 500 mg levetiracetam orally twice daily." | 5.56 | Phenytoin Seizure Prophylaxis Therapy Resulting in Severe Thrombocytopenia After Brain Tumor Debulking Surgery. ( Al Ghamdi, RM; Ben Ali, H; Turkistani, AN, 2020) |
| "To describe a patient with severe thrombocytopenia induced by the administration of phenytoin for prevention of seizures." | 3.69 | Phenytoin-induced thrombocytopenia. ( Holtzer, CD; Reisner-Keller, LA, 1997) |
| "During earlier investigations of the hepatic effects in dogs of long-term administration of phenytoin alone or in combination with primidone, erythrocytic macrocytosis, neutropenia, neutrophilic hypersegmentation, and thrombocytopenia were observed." | 3.68 | Hematologic values and plasma and tissue folate concentrations in dogs given phenytoin on a long-term basis. ( Bunch, SE; Cullen, JM; Easley, JR, 1990) |
| "Combined use of cimetidine and phenytoin among 1512 neurosurgical patients has led to severe thrombocytopenia in 4 patients." | 3.67 | Severe thrombocytopenia due to combined cimetidine and phenytoin therapy. ( Chan, KH; Mann, KS; Yue, CP, 1987) |
| "A 67-year-old man developed a sudden onset of severe isolated thrombocytopenia (platelet count, 1000/mm3) after 10 days of phenytoin administration as a prophylactic measure prior to craniotomy." | 3.67 | Severe thrombocytopenia associated with phenytoin and cimetidine therapy. ( Brown, FD; Lichtor, T; Wong, YY, 1985) |
| "Sudden, severe thrombocytopenia developed in each of three patients receiving diphenylhydantion, diazepam, and sulfisoxazole, respectively." | 3.65 | Detection of drug-dependent antibodies by the 51Cr platelet lysis test: documentation of immune thrombocytopenia induced by diphenylhydantoin, diazepam, and sulfisoxazole. ( Aster, RH; Cimo, PL; Desai, RG; Pino, JL; Pisciotta, AV, 1977) |
| "Rare, serious adverse effects of antiepileptic drugs (AEDs) include hepatotoxicity and bone marrow suppression." | 2.38 | Routine laboratory monitoring for serious adverse effects of antiepileptic medications: the controversy. ( Wyllie, E; Wyllie, R, 1991) |
| "Severe thrombocytopenia was managed first by transfusion of 17 units of platelets and by cessation of intravenous phenytoin plus the starting of 500 mg levetiracetam orally twice daily." | 1.56 | Phenytoin Seizure Prophylaxis Therapy Resulting in Severe Thrombocytopenia After Brain Tumor Debulking Surgery. ( Al Ghamdi, RM; Ben Ali, H; Turkistani, AN, 2020) |
| "Phenytoin was discontinued and she was given intravenous immunoglobulin for 2 days." | 1.38 | Drug-induced thrombocytopenia: a less known interaction. ( Pandey, M; Yarlagadda, L, 2012) |
| "Drug-induced thrombocytopenia is a clinically important adverse drug event involving many drugs including hydantoins." | 1.36 | Possible acute thrombocytopenia post esomeprazole and hydantoin coadministration. ( Manor, SM; Ranzino, AM; Sorrells, KR, 2010) |
| "The phenytoin was replaced by carbamazepine and the patient subsequently developed erythroid hypoplasia, neutropenia and persistent thrombocytopenia." | 1.27 | Anticonvulsant-induced marrow suppression and immune thrombocytopenia. ( Berger, S; Falk, J; Keating, A; Kelton, JG; Klein, M; McIlroy, WJ; Messner, H; Schweiger, FJ, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 20 (58.82) | 18.7374 |
| 1990's | 7 (20.59) | 18.2507 |
| 2000's | 4 (11.76) | 29.6817 |
| 2010's | 2 (5.88) | 24.3611 |
| 2020's | 1 (2.94) | 2.80 |
| Authors | Studies |
|---|---|
| Al Ghamdi, RM | 1 |
| Turkistani, AN | 1 |
| Ben Ali, H | 1 |
| Mendhekar, D | 1 |
| Duggal, H | 1 |
| Andrade, C | 1 |
| Ranzino, AM | 1 |
| Sorrells, KR | 1 |
| Manor, SM | 1 |
| Pandey, M | 1 |
| Yarlagadda, L | 1 |
| REICHELDERFER, TE | 1 |
| PEARSON, PH | 1 |
| LIVINGSTON, S | 1 |
| WEINTRAUB, RM | 1 |
| PECHET, L | 1 |
| ALEXANDER, B | 1 |
| SPARBERG, M | 1 |
| Morozov, GV | 1 |
| Semenova, NV | 1 |
| Slastenko, OA | 1 |
| Mishchenko, AL | 1 |
| Lin, SC | 1 |
| Shyur, SD | 1 |
| Wu, JY | 1 |
| Ma, YC | 1 |
| Thorning, G | 1 |
| Raghavan, K | 1 |
| Skillrud, DM | 1 |
| Goldstein, NP | 1 |
| Cacatian, AA | 1 |
| Rando, J | 1 |
| Arbiser, JL | 1 |
| Goldstein, AM | 1 |
| Gordon, D | 1 |
| Hatton, J | 1 |
| Lu, WY | 1 |
| Rhoney, DH | 1 |
| Tibbs, PA | 1 |
| Dempsey, RJ | 1 |
| Young, B | 1 |
| Holtzer, CD | 1 |
| Reisner-Keller, LA | 1 |
| Alehan, FK | 1 |
| Russell, EC | 1 |
| Pellock, JM | 1 |
| Addington, WW | 1 |
| Fincham, RW | 1 |
| Hamilton, HE | 1 |
| Schottelius, DD | 1 |
| Cimo, PL | 1 |
| Pisciotta, AV | 1 |
| Desai, RG | 1 |
| Pino, JL | 1 |
| Aster, RH | 1 |
| Wyllie, E | 1 |
| Wyllie, R | 1 |
| Bunch, SE | 1 |
| Easley, JR | 1 |
| Cullen, JM | 1 |
| Noda, M | 1 |
| Matsui, K | 1 |
| Kitagawa, M | 1 |
| Ohta, M | 1 |
| Howrie, DL | 1 |
| Schwinghammer, TL | 1 |
| Wollman, M | 1 |
| Schweiger, FJ | 1 |
| Kelton, JG | 1 |
| Messner, H | 1 |
| Klein, M | 1 |
| Berger, S | 1 |
| McIlroy, WJ | 1 |
| Falk, J | 1 |
| Keating, A | 1 |
| DeSwarte, RD | 1 |
| Yue, CP | 1 |
| Mann, KS | 1 |
| Chan, KH | 1 |
| Hadnagy, C | 1 |
| Macavei, I | 1 |
| Bornuz, F | 1 |
| Marinca, E | 1 |
| Sass, G | 1 |
| Wong, YY | 1 |
| Lichtor, T | 1 |
| Brown, FD | 1 |
| Pochedly, C | 1 |
| Ente, G | 1 |
| Bergamaschi, P | 1 |
| Imparato, E | 1 |
| Parker, WA | 1 |
| Gumnit, RJ | 1 |
| Yunis, AA | 1 |
| Bottomley, WK | 1 |
| Eklind, RR | 1 |
| Moffitt, WC | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Comparison of Esomeprazole and Famotidine for Stress Ulcer Prophylaxis in Neurosurgical Intensive Care Unit[NCT00633035] | Phase 4 | 60 participants (Actual) | Interventional | 2007-09-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
5 reviews available for phenytoin and Thrombocytopenia
| Article | Year |
|---|---|
DIAGNOSTICALLY CONFUSING COMPLICATIONS OF DIPHENYLHYDANTOIN THERAPY. A REVIEW.
Topics: Adrenal Insufficiency; Anemia; Anemia, Aplastic; Anemia, Macrocytic; Conjunctivitis; Electrocardiogr | 1963 |
Routine laboratory monitoring for serious adverse effects of antiepileptic medications: the controversy.
Topics: Anemia, Aplastic; Anticonvulsants; Carbamazepine; Chemical and Drug Induced Liver Injury; Drug Monit | 1991 |
Drug allergy: an overview.
Topics: Anaphylaxis; Anemia; Boston; Desensitization, Immunologic; Drug Hypersensitivity; Fever; Humans; Liv | 1986 |
Adverse hematologic effects of drugs.
Topics: Anemia, Hemolytic; Anemia, Macrocytic; Anti-Bacterial Agents; Anticonvulsants; Antidepressive Agents | 1972 |
Drug--induced bone marrow injury.
Topics: Adult; Agranulocytosis; Anemia, Aplastic; Bone Marrow Diseases; Child, Preschool; Chloramphenicol; H | 1969 |
29 other studies available for phenytoin and Thrombocytopenia
| Article | Year |
|---|---|
Phenytoin Seizure Prophylaxis Therapy Resulting in Severe Thrombocytopenia After Brain Tumor Debulking Surgery.
Topics: Adult; Anticonvulsants; Brain Neoplasms; Cytoreduction Surgical Procedures; Humans; Immunoglobulins, | 2020 |
Leukopenia and thrombocytopenia on adding aripiprazole to phenytoin.
Topics: Adult; Anticonvulsants; Antipsychotic Agents; Aripiprazole; Drug Therapy, Combination; Female; Human | 2009 |
Possible acute thrombocytopenia post esomeprazole and hydantoin coadministration.
Topics: Anticonvulsants; Blood Platelets; Esomeprazole; Humans; Male; Middle Aged; Phenytoin; Platelet Count | 2010 |
Drug-induced thrombocytopenia: a less known interaction.
Topics: Anticonvulsants; Dexamethasone; Drug Interactions; Female; Glucocorticoids; Humans; Immunoglobulins, | 2012 |
Thrombocytopenic purpura occurring in association with paradione (paramethadione) and dilantin sodium (phenytoin sodium) therapy.
Topics: Anticonvulsants; Humans; Oxazoles; Phenytoin; Purpura; Purpura, Thrombocytopenic; Sodium; Thrombocyt | 1953 |
Rapid diagnosis of drug-induced thrombocytopenic purpura. Report of three cases due to quinine, quinidine, and Dilantin.
Topics: Humans; Hydantoins; Phenytoin; Purpura; Purpura, Thrombocytopenic; Quinidine; Quinine; Thrombocytope | 1962 |
[Influence of psychotropic drugs on thrombocytes aggregation in patients with epilepsy].
Topics: Adolescent; Adult; Barbiturates; Carbamazepine; Epilepsy; Humans; In Vitro Techniques; Lamotrigine; | 2004 |
Focal seizures as an unusual presentation of neonatal lupus erythematosus.
Topics: Anemia; Anticonvulsants; Autoantigens; Humans; Infant, Newborn; Lupus Erythematosus, Cutaneous; Lupu | 2005 |
Fatal phenytoin-induced thrombocytopaenia in a neurosurgical patient.
Topics: Aged; Anticonvulsants; Fatal Outcome; Female; Glasgow Coma Scale; Humans; Neurosurgical Procedures; | 2007 |
Paroxysmal limb hemiataxia with crossed facial paresthesias in multiple sclerosis.
Topics: Adult; Ataxia; Carbamazepine; Face; Humans; Male; Multiple Sclerosis; Paresthesia; Phenytoin; Thromb | 1983 |
Diphenylhydantoin-induced pseudolymphoma syndrome. With severe thrombocytopenia.
Topics: Adult; Diagnosis, Differential; Female; Humans; Immunoblastic Lymphadenopathy; Phenytoin; Thrombocyt | 1981 |
Thrombocytopenia following administration of phenytoin, dexamethasone and cimetidine: a case report and a potential mechanism.
Topics: Aged; Aged, 80 and over; Cimetidine; Dexamethasone; Drug Interactions; Female; Humans; Phenytoin; Th | 1993 |
A step-wise protocol for stress ulcer prophylaxis in the neurosurgical intensive care unit.
Topics: Adult; Cimetidine; Clinical Protocols; Critical Care; Drug Therapy, Combination; Gastric Acid; Gastr | 1996 |
Phenytoin-induced thrombocytopenia.
Topics: Adult; Anticonvulsants; Female; Humans; Phenytoin; Seizures; Thrombocytopenia | 1997 |
Phenytoin-associated thrombocytopenia in a toddler.
Topics: Anticonvulsants; Child, Preschool; Dandy-Walker Syndrome; Epilepsy; Female; Humans; Phenytoin; Throm | 1999 |
The side effects and interactions of antituberculosis drugs.
Topics: Adult; Aminosalicylic Acid; Antitubercular Agents; Central Nervous System Diseases; Chemical and Dru | 1979 |
Late-onset thrombocytopenia with phenytoin therapy.
Topics: Humans; Middle Aged; Phenytoin; Thrombocytopenia; Time Factors | 1979 |
Detection of drug-dependent antibodies by the 51Cr platelet lysis test: documentation of immune thrombocytopenia induced by diphenylhydantoin, diazepam, and sulfisoxazole.
Topics: Adolescent; Antibodies; Antibody Specificity; Blood Platelets; Chromium Radioisotopes; Diazepam; Fem | 1977 |
Hematologic values and plasma and tissue folate concentrations in dogs given phenytoin on a long-term basis.
Topics: Animals; Blood Cell Count; Dog Diseases; Dogs; Erythrocytes; Female; Folic Acid; Folic Acid Deficien | 1990 |
Werner's syndrome with myelofibrosis following diphenylhydantoin therapy after meningiomectomy. An autopsy case.
Topics: Adult; Consanguinity; Humans; Male; Meningeal Neoplasms; Meningioma; Phenytoin; Primary Myelofibrosi | 1990 |
Use of i.v. immune globulin for treatment of phenytoin-induced thrombocytopenia.
Topics: Adolescent; Humans; Immunoglobulins; Male; Phenytoin; Thrombocytopenia | 1989 |
Anticonvulsant-induced marrow suppression and immune thrombocytopenia.
Topics: Antigen-Antibody Complex; Blood Platelets; Bone Marrow; Carbamazepine; Cells, Cultured; Female; Gran | 1988 |
Severe thrombocytopenia due to combined cimetidine and phenytoin therapy.
Topics: Adult; Aged; Bone Marrow Diseases; Cimetidine; Humans; Male; Phenytoin; Thrombocytopenia | 1987 |
[Bone marrow-damaging effect of various drugs].
Topics: Antitubercular Agents; Bone Marrow; Chloramphenicol; Drug Hypersensitivity; Drug Therapy, Combinatio | 1985 |
Severe thrombocytopenia associated with phenytoin and cimetidine therapy.
Topics: Aged; Cimetidine; Humans; Male; Phenytoin; Thrombocytopenia | 1985 |
[Gynecological aspects of thrombocytopenia].
Topics: Adult; Analgesics; Anti-Bacterial Agents; Anti-Inflammatory Agents; Antineoplastic Agents; Contracep | 1972 |
Diphenylhydantoin toxicity: dose-dependent blood dyscrasia.
Topics: Adult; Amenorrhea; Dose-Response Relationship, Drug; Epilepsy; Female; Humans; Hypothermia; Hypothyr | 1974 |
Case report: diphenylhydantoin sodium-induced thrombocytopenia and leukopenia.
Topics: Agranulocytosis; Dentistry; Phenytoin; Thrombocytopenia | 1971 |
Carbamazepine (Tegretol).
Topics: Agranulocytosis; Anemia, Aplastic; Blood Platelet Disorders; Carbamazepine; Dibenzazepines; Hematolo | 1968 |