phenytoin has been researched along with Stevens-Johnson Syndrome in 127 studies
Stevens-Johnson Syndrome: Rare cutaneous eruption characterized by extensive KERATINOCYTE apoptosis resulting in skin detachment with mucosal involvement. It is often provoked by the use of drugs (e.g., antibiotics and anticonvulsants) or associated with PNEUMONIA, MYCOPLASMA. It is considered a continuum of Toxic Epidermal Necrolysis.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are severe cutaneous adverse reactions that can be induced by phenytoin (PHT)." | 8.98 | Association of CYP2C9*3 with phenytoin-induced Stevens-Johnson syndrome and toxic epidermal necrolysis: A systematic review and meta-analysis. ( Liu, W; Wu, X; Zhou, W, 2018) |
| "Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are fatal adverse cutaneous drug reactions which may be induced by phenytoin (PHT) or lamotrigine (LTG)." | 8.91 | HLA-B*1502 increases the risk of phenytoin or lamotrigine induced Stevens-Johnson Syndrome/toxic epidermal necrolysis: evidence from a meta-analysis of nine case-control studies. ( Huo, J; Li, X; Mei, S; Wang, J; Yu, K; Zhao, Z; Zhu, Y, 2015) |
| "To report a rare case of drug induced overlap of Stevens-Johnson syndrome and Toxic Epidermal Necrosis Syndrome exacerbated by cephalexin." | 8.12 | Phenytoin induced Stevens-Johnson Syndrome-toxic Epidermal Necrolysis Overlap Exacerbated by Cephalexin in a 65-Year-old Neurosurgical Patient: A Rare Case Report. ( Mahalingam, VT; Nuthalapati, P; Rathinam, KK; Sabarathinam, S, 2022) |
| "Previous studies have found an association between HLA-B*1502 allele and lamotrigine-induced Stevens-Johnson syndrome (SJS)/ toxic epidermal necrosis (TEN) spectrum in Han Chinese populations." | 8.02 | Investigating the association of Lamotrigine and Phenytoin-induced Stevens-Johnson syndrome/Toxic Epidermal Necrolysis with HLA-B*1502 in Iranian population. ( Afkhami Ardakani, S; Eslahi, A; Farrokhi, S; Jarahi, L; Kiafar, B; Mojarad, M; Mortezaee, R; Sabourirad, S; Shahrokhi, Y, 2021) |
| "The goal of our study was to investigate the incidence of Stevens-Johnson syndrome (SJS), the frequency of SJS diagnosis, and the association between SJS and prior use of allopurinol, carbamazepine or phenytoin." | 7.88 | Incidence of Stevens-Johnson syndrome following combination drug use of allopurinol, carbamazepine and phenytoin in Taiwan: A case-control study. ( Cheng, CY; Cheng, FJ; Chuang, PC; Huang, YS; Pan, HY; Syu, FK, 2018) |
| "Phenytoin (PHE) and carbamazepine (CBZ) are first rank causative drugs that can induce drug rash with eosinophilia and systemic symptoms (DRESS) and Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN)." | 7.88 | Evaluation of a lymphocyte transformation test and cytokine detection assay to identify phenytoin and carbamazepine provoked DRESS or SJS/TEN in epilepsy patients. ( Kumkamthornkul, P; Srinoulprasert, Y; Tansit, T; Tuchinda, P; Udnaen, S, 2018) |
| "Previous studies have reported that patients with phenytoin-induced Stevens-Johnson syndrome and toxic epidermal necrolysis (PHT-induced SJS/TEN) were positive for HLA-B*1502." | 7.77 | HLA-B*1502 genotyping in two Chinese patients with phenytoin-induced Stevens-Johnson syndrome. ( Liao, WP; Liu, XR; Min, FL; Shi, YW, 2011) |
| "A 46 year old male patient with metastatic prostate cancer developed Stevens-Johnson syndrome (SJS), initially in three well-demarcated areas on his scalp, chest and back, corresponding to ports of radiation therapy while on phenytoin." | 7.76 | Multifocal Stevens-Johnson syndrome after concurrent phenytoin and cranial and thoracic radiation treatment, a case report. ( Dvorak, T; Kandil, AO; Mignano, J; Wu, JK; Zhu, JJ, 2010) |
| " At the beginning of cranial radiation therapy, prophylactic oral ranitidine, oral dexamethasone, and oral phenytoin were initiated to prevent seizures." | 7.74 | Erythema multiforme associated with prophylactic use of phenytoin during cranial radiation therapy. ( Barbosa, LA; Teixeira, CR, 2008) |
| "Previous studies found a strong association between HLA-B*1502 and carbamazepine (CBZ)-induced Stevens-Johnson syndrome (SJS) in Han Chinese, but not in Caucasian populations." | 7.74 | Carbamazepine and phenytoin induced Stevens-Johnson syndrome is associated with HLA-B*1502 allele in Thai population. ( Desudchit, T; Hirankarn, N; Kangwanshiratada, O; Korkij, W; Limotai, C; Locharernkul, C; Loplumlert, J; Shotelersuk, V; Suphapeetiporn, K; Tongkobpetch, S, 2008) |
| "Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are severe cutaneous adverse reactions that can be induced by phenytoin (PHT)." | 4.98 | Association of CYP2C9*3 with phenytoin-induced Stevens-Johnson syndrome and toxic epidermal necrolysis: A systematic review and meta-analysis. ( Liu, W; Wu, X; Zhou, W, 2018) |
| "Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are fatal adverse cutaneous drug reactions which may be induced by phenytoin (PHT) or lamotrigine (LTG)." | 4.91 | HLA-B*1502 increases the risk of phenytoin or lamotrigine induced Stevens-Johnson Syndrome/toxic epidermal necrolysis: evidence from a meta-analysis of nine case-control studies. ( Huo, J; Li, X; Mei, S; Wang, J; Yu, K; Zhao, Z; Zhu, Y, 2015) |
| "Erythema multiforme major (EMM; Stevens-Johnson syndrome) is a cutaneous disorder associated with a wide variety of factors including ingestion of drugs such as phenytoin and exposure to intracranial radiation therapy." | 4.80 | Increased risk of erythema multiforme major with combination anticonvulsant and radiation therapies. ( Han, N; Linthicum, K; Micali, G; West, DP, 1999) |
| "Three recent publications have reported the development of erythema multiforme and Stevens-Johnson syndrome in patients receiving cranial irradiation and sodium phenytoin." | 4.79 | Is phenytoin contraindicated in patients receiving cranial irradiation? ( Borg, MF; Probert, JC; Zwi, LJ, 1995) |
| "To report a rare case of drug induced overlap of Stevens-Johnson syndrome and Toxic Epidermal Necrosis Syndrome exacerbated by cephalexin." | 4.12 | Phenytoin induced Stevens-Johnson Syndrome-toxic Epidermal Necrolysis Overlap Exacerbated by Cephalexin in a 65-Year-old Neurosurgical Patient: A Rare Case Report. ( Mahalingam, VT; Nuthalapati, P; Rathinam, KK; Sabarathinam, S, 2022) |
| "Previous studies have found an association between HLA-B*1502 allele and lamotrigine-induced Stevens-Johnson syndrome (SJS)/ toxic epidermal necrosis (TEN) spectrum in Han Chinese populations." | 4.02 | Investigating the association of Lamotrigine and Phenytoin-induced Stevens-Johnson syndrome/Toxic Epidermal Necrolysis with HLA-B*1502 in Iranian population. ( Afkhami Ardakani, S; Eslahi, A; Farrokhi, S; Jarahi, L; Kiafar, B; Mojarad, M; Mortezaee, R; Sabourirad, S; Shahrokhi, Y, 2021) |
| "Phenytoin (PHE) and carbamazepine (CBZ) are first rank causative drugs that can induce drug rash with eosinophilia and systemic symptoms (DRESS) and Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN)." | 3.88 | Evaluation of a lymphocyte transformation test and cytokine detection assay to identify phenytoin and carbamazepine provoked DRESS or SJS/TEN in epilepsy patients. ( Kumkamthornkul, P; Srinoulprasert, Y; Tansit, T; Tuchinda, P; Udnaen, S, 2018) |
| "The presence of HLA-B*15:02 allele is considered a risk factor for development of Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) in patients taking aromatic anticonvulsant drugs like carbamazepine and phenytoin." | 3.88 | The association of HLA B*15:02 allele and Stevens-Johnson syndrome/toxic epidermal necrolysis induced by aromatic anticonvulsant drugs in a South Indian population. ( Devi, K, 2018) |
| "The goal of our study was to investigate the incidence of Stevens-Johnson syndrome (SJS), the frequency of SJS diagnosis, and the association between SJS and prior use of allopurinol, carbamazepine or phenytoin." | 3.88 | Incidence of Stevens-Johnson syndrome following combination drug use of allopurinol, carbamazepine and phenytoin in Taiwan: A case-control study. ( Cheng, CY; Cheng, FJ; Chuang, PC; Huang, YS; Pan, HY; Syu, FK, 2018) |
| "Phenytoin (PHT) is a common cause of severe cutaneous adverse reactions (SCARs), including Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN) and drug reaction with eosinophilia and systemic symptoms (DRESS)." | 3.85 | Association of HLA-B*15:13 and HLA-B*15:02 with phenytoin-induced severe cutaneous adverse reactions in a Malay population. ( Chang, CC; Choon, SE; Chung, WH; Hussein, SH; Lee, CK; Lim, KS; Murad, S; Ng, CC; Too, CL, 2017) |
| "Phenytoin is one of the most common causative drugs of several types of severe cutaneous adverse reactions (SCAR) such as Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and drug reactions with eosinophilia and systemic symptoms (DRESS)." | 3.83 | Associations between HLA class I and cytochrome P450 2C9 genetic polymorphisms and phenytoin-related severe cutaneous adverse reactions in a Thai population. ( Chumworathayi, P; Khunarkornsiri, U; Kongpan, T; Konyoung, P; Kulkantrakorn, K; Mahasirimongkol, S; Nakkam, N; Prabmeechai, N; Rerkpattanapipat, T; Saksit, N; Sangviroon, A; Satapornpong, P; Sukasem, C; Tassaneeyakul, W; Tiamkao, S; Vannaprasaht, S; Wichukchinda, N, 2016) |
| "We aim to estimate the incidence of Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) among tetrazepam users and compare it with benzodiazepine users in a Spanish primary care database (BIFAP)." | 3.81 | Risk of toxic epidermal necrolysis and Stevens-Johnson syndrome associated with benzodiazepines: a population-based cohort study. ( de Abajo, FJ; Gil, M; Martín-Merino, E, 2015) |
| "The antiepileptic drug phenytoin can cause cutaneous adverse reactions, ranging from maculopapular exanthema to severe cutaneous adverse reactions, which include drug reactions with eosinophilia and systemic symptoms, Stevens-Johnson syndrome, and toxic epidermal necrolysis." | 3.80 | Genetic variants associated with phenytoin-related severe cutaneous adverse reactions. ( Azukizawa, H; Chang, CJ; Chang, CN; Chang, WC; Chang, YS; Chen, DY; Chen, MJ; Chen, TJ; Choon, SE; Chuang, SS; Chung, WH; Ho, HC; Ho, JC; Hsih, MS; Hsu, CK; Hsu, CN; Hui, RC; Hung, SI; Kaniwa, N; Lee, YS; Lin, CY; Lin, JY; Liu, CS; Nakamura, R; Saito, Y; Shi, Y; Takahashi, Y; Tsai, SF; Tu, PH; Wang, TH; Wu, T; Wu, TL; Wu, WM; Wu, YR; Wu, YY; Yang, CH, 2014) |
| "Asians who carry the HLA-B*1502 allele have an elevated risk of developing Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) when treated with the antiepileptic drugs (AEDs) carbamazepine (CBZ) and phenytoin (PHT)." | 3.78 | Cost-effectiveness of HLA-B*1502 genotyping in adult patients with newly diagnosed epilepsy in Singapore. ( Dong, D; Finkelstein, EA; Sung, C, 2012) |
| "Previous studies have reported that patients with phenytoin-induced Stevens-Johnson syndrome and toxic epidermal necrolysis (PHT-induced SJS/TEN) were positive for HLA-B*1502." | 3.77 | HLA-B*1502 genotyping in two Chinese patients with phenytoin-induced Stevens-Johnson syndrome. ( Liao, WP; Liu, XR; Min, FL; Shi, YW, 2011) |
| "A 46 year old male patient with metastatic prostate cancer developed Stevens-Johnson syndrome (SJS), initially in three well-demarcated areas on his scalp, chest and back, corresponding to ports of radiation therapy while on phenytoin." | 3.76 | Multifocal Stevens-Johnson syndrome after concurrent phenytoin and cranial and thoracic radiation treatment, a case report. ( Dvorak, T; Kandil, AO; Mignano, J; Wu, JK; Zhu, JJ, 2010) |
| "A previous study conducted in Taiwan found a 100% association between HLA-B*1502 allele and carbamazepine-induced Stevens-Johnson syndrome (SJS) in Han Chinese subjects, with an extremely high odds ratio compared with carbamazepine-tolerant subjects (odds ratio = 2,504)." | 3.74 | Association between HLA-B*1502 allele and antiepileptic drug-induced cutaneous reactions in Han Chinese. ( Baum, L; Cheng, AS; Kwan, P; Lau, KM; Man, CB; Ng, MH; Yu, E, 2007) |
| "Toxic epidermal necrolysis (TEN) and Stevens-Johnson syndrome (SJS) have been associated with some drugs, particularly anticonvulsants such as phenytoin." | 3.74 | [Toxic epidermal necrolysis induced by phenytoin and whole brain radiotherapy]. ( Fernández, FA; Garcés, FJ; Pintor, E; Quesada, R, 2007) |
| "Previous studies found a strong association between HLA-B*1502 and carbamazepine (CBZ)-induced Stevens-Johnson syndrome (SJS) in Han Chinese, but not in Caucasian populations." | 3.74 | Carbamazepine and phenytoin induced Stevens-Johnson syndrome is associated with HLA-B*1502 allele in Thai population. ( Desudchit, T; Hirankarn, N; Kangwanshiratada, O; Korkij, W; Limotai, C; Locharernkul, C; Loplumlert, J; Shotelersuk, V; Suphapeetiporn, K; Tongkobpetch, S, 2008) |
| " At the beginning of cranial radiation therapy, prophylactic oral ranitidine, oral dexamethasone, and oral phenytoin were initiated to prevent seizures." | 3.74 | Erythema multiforme associated with prophylactic use of phenytoin during cranial radiation therapy. ( Barbosa, LA; Teixeira, CR, 2008) |
| "Across a range of assumptions used, the risk of hospitalization for Stevens-Johnson syndrome or toxic epidermal necrolysis in new users is low for carbamazepine, lamotrigine, phenytoin, phenobarbital, and valproic acid." | 3.73 | Risk of Stevens-Johnson syndrome and toxic epidermal necrolysis in new users of antiepileptics. ( Messenheimer, J; Mockenhaupt, M; Schlingmann, J; Tennis, P, 2005) |
| "There are few reports about Stevens-Johnson syndrome, a bullous form of erythema multiforme, that can develop in patients treated with cranial irradiation and antiepileptic drugs, especially with phenytoin." | 3.72 | Toxic epidermal necrolysis after cranial radiotherapy and phenytoin treatment. ( Demirkesen, C; Koca, S; Oner Dincbas, F; Uzel, O; Yörük, S, 2004) |
| " The extensive involvement of the oral mucosa with conjunctivitis and synechiae of the eyelids, facial swelling, and extension of the rash over the trunk and shoulders with bullous detachment of less than 10% of the total body surface strongly suggested Stevens-Johnson syndrome caused by phenytoin treatment in our patient." | 3.71 | Stevens-Johnson syndrome in a patient receiving anticonvulsant therapy during cranial irradiation. ( Aydiner, A; Eralp, Y; Saip, P; Taş, F; Topuz, E, 2001) |
| " Phenytoin, on the other hand, causes gingival hyperplasia in many patients, irreversible hypertrichosis in some patients and lethal reactions, such as Stevens-Johnson syndrome, in a few patients." | 3.66 | Phenobarbital vs. phenytoin for grand mal epilepsy. ( Kramer, II; Livingston, S; Pauli, LL; Pruce, I, 1980) |
| "The case of a 19-year-old patient is reported who during treatment with phenytoin (5,5-dephenylhydantoin) developed a Stevens-Johnson syndrome." | 3.65 | [Stevens-Johnson syndrome as an early allergic reaction to diphenylhydantoin]. ( Marg, E, 1976) |
| "Phenytoin is an antiepileptic drug with a narrow therapeutic index and large interpatient pharmacokinetic variability, partly due to genetic variation in CYP2C9." | 2.72 | Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2C9 and HLA-B Genotypes and Phenytoin Dosing: 2020 Update. ( Callaghan, JT; Caudle, KE; Fohner, AE; Formea, CM; Gaedigk, A; Huddart, R; Karnes, JH; Klein, TE; Llerena, A; Mintzer, S; Phillips, EJ; Rettie, AE; Somogyi, AA; Ta Michael Lee, M; Whirl-Carrillo, M, 2021) |
| "Studies assessing SCARs using real-world evidence are very limited." | 1.72 | Analysis of severe cutaneous adverse reactions (SCARs) in Taiwan drug-injury relief system: 18-year results. ( Chen, WW; Chien, MY; Chiou, MH; Chu, CY; Huang, PW, 2022) |
| "Severe cutaneous adverse reactions (SCARs) are potentially lethal adverse drug reactions that involve the skin, mucous membranes, and internal organs, resulting in disability." | 1.72 | Severe cutaneous adverse reactions: A 5-year retrospective study at Hospital Melaka, Malaysia, from December 2014 to February 2020. ( Abdullah, NH; Kristummoonthy, P; Lee, CS; Tee, CT, 2022) |
| "SCARs, including drug reaction with eosinophilia and systemic symptoms (DRESS), Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN), are associated with a variation in HLA genotypes." | 1.56 | Association of HLA genotypes with phenytoin induced severe cutaneous adverse drug reactions in Thai children. ( Benjaponpitak, S; Inunchot, W; Kamchaisatian, W; Khongkhatithuml, C; Likkasittipan, P; Mahasirimongkol, S; Manuyakorn, W; Suvichapanich, S; Thampratankul, L; Wattanapokayakit, S; Wichukchinda, N, 2020) |
| "Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are immune-mediated diseases characterized by an extensive loss of the epidermal skin layer, often resulting in death." | 1.56 | Antiepileptic combination therapy with Stevens-Johnson syndrome and toxic epidermal necrolysis: Analysis of a Japanese pharmacovigilance database. ( Hayashi, T; Noguchi, Y; Tachi, T; Takaoka, M; Teramachi, H, 2020) |
| "Hepatitis was the most frequent complication (67." | 1.40 | Clinical profiles of Stevens-Johnson syndrome among Thai patients. ( Choonhakarn, C; Kongbunkiat, K; Limpawattana, P, 2014) |
| "Stevens-Johnson syndrome and toxic epidermal necrolysis contribute significantly to morbidity and mortality of patients on the dermatology ward although mortality was low compared to other studies." | 1.39 | Stevens-Johnson syndrome and toxic epidermal necrolysis at the University Hospital of the West Indies, Jamaica. ( East-Innis, AD; Thompson, DS, 2013) |
| "Lyell's syndrome or toxic epidermal necrolysis (TEN) is a rare dermatological disease that causes serious morbidity and mortality." | 1.38 | Phenytoin-induced Lyell's syndrome. ( Lobão, B; Marques, S; Martins, C; Pedroso, E; Sousa, M, 2012) |
| "This survey considers 8 cases of toxic epidermal necrolysis diagnosed and treated in our clinic from 2003 to 2007." | 1.36 | Basic measures and systemic medical treatment of patients with toxic epidermal necrolysis. ( Hanken, I; Sander, CA; Schimmer, M, 2010) |
| " The use of systemic corticosteroids in the treatment of TEN is controversial because of a lack of randomized, controlled, prospective studies, and because the effects of steroid therapy vary depending on the dosage and time of its administration during the course of TEN." | 1.35 | Skin biopsies to assess response to systemic corticosteroid therapy in early-stage TEN: case report and review of the literature. ( Céspedes, YP; Nigra, TP; O'Donoghue, JM; Rockley, PF, 2009) |
| "Therapeutic measures included seizure prophylaxis with phenytoin and total brain radiation therapy of brain metastases from bronchial carcinoma." | 1.33 | EMPACT syndrome. ( Loewe, R; Pickl, WF; Stingl, G; Wagner, SN; Wöhrl, S, 2005) |
| "Phenytoin was commenced postoperatively after a craniotomy resection of a glioblastoma multiforme." | 1.32 | Phenytoin-induced linear IgA dermatosis mimicking toxic epidermal necrolysis. ( Kossard, S; Shumack, S; Tran, D, 2003) |
| "Because the therapy for toxic epidermal necrolysis and acute graft-versus-host disease differs largely from the others, it is necessary to make an accurate diagnosis." | 1.31 | Toxic epidermal necrolysis after phenytoin usage in a brain trauma patient. ( Kuwert, C; Schummer, C; Schummer, W, 2002) |
| "Toxic epidermal necrolysis is a severe reaction with skin involvement induced by different drugs and other agents." | 1.31 | Anticonvulsant-induced toxic epidermal necrolysis: monitoring the immunologic response. ( Besso, G; Blanca, M; del Moral, RG; Juárez, C; Leyva, L; O'Valle, F; Posadas, S; Santamaría, LF; Torres, MJ, 2000) |
| "The 3 patients had a severe dry eye syndrome." | 1.31 | [Lyell's syndrome and its ophthalmologic manifestations in Cameroon]. ( Beharcohen, F; Dighiero, P; Moussala, M; Renard, G, 2000) |
| "Toxic epidermal necrolysis is a rare but acute life-threatening syndrome in which the epidermis blisters and peels in large sheets." | 1.31 | Anesthetic management of toxic epidermal necrolysis: report of three adult cases. ( Candido, KD; Konefal, TS; Rabito, SF; Sultana, S, 2001) |
| "Oxazepam was stopped and a second series of dexamethasone pulse therapy was given." | 1.31 | Successful dexamethasone pulse therapy in a toxic epidermal necrolysis (TEN) patient featuring recurrent TEN to oxazepam. ( Beerthuizen, G; de Jong, MC; Jonkman, MF; Kardaun, SH; Nieuwenhuis, P; Schuttelaar, ML; Toth, GG; van der Meer, JB, 2001) |
| "We have evaluated their activity in toxic epidermal necrolysis (TEN)." | 1.30 | Gelatinases in drug-induced toxic epidermal necrolysis. ( Lapière, CM; Nusgens, BV; Paquet, P; Piérard, GE, 1998) |
| "In particular, in patients with AIDS who are more susceptible for adverse drug reactions and who are simultaneously receiving a variety of drugs with a considerable potential of cutaneous side effects, therapy cannot be withhold for lack of therapeutic alternatives." | 1.29 | [Drug-induced Stevens-Johnson syndrome in a patient with AIDS]. ( Bircher, A; Haefeli, WE; Leib, SL; Lüscher, TF; Schlienger, RG, 1993) |
| "We present a case of phenytoin-induced toxic epidermal necrolysis resulting in 60-70% skin involvement." | 1.29 | Phenytoin-induced toxic epidermal necrolysis: a case report. ( Creamer, JD; Kerr-Muir, M; Smith, NP; Whittaker, SJ, 1996) |
| " The dramatic response of our patients to cyclophosphamide, which is known to inhibit cell-mediated cytotoxicity by inhibiting both the recognition and lethal hit stages, together with the rapid regrowth of the epidermis within 4 days to a week in patients who received adequate dosage of the drug, supports the preceding concepts." | 1.28 | Efficacy of cyclophosphamide in toxic epidermal necrolysis. Clinical and pathophysiologic aspects. ( Allen, SG; Heng, MC, 1991) |
| "Toxic epidermal necrolysis is a rare but often fatal hypersensitivity reaction to numerous agents, including most anticonvulsants." | 1.28 | Fatal phenytoin-related toxic epidermal necrolysis: case report. ( Hope, DG; Kelly, DF, 1989) |
| "A 35-year-old woman developed toxic epidermal necrolysis secondary to phenytoin." | 1.28 | Drug-induced toxic epidermal necrolysis treated with cyclosporin. ( Daman, LA; Grant-Kels, JM; Renfro, L, 1989) |
| "Drug-induced toxic epidermal necrolysis has a mortality of greater than 50%." | 1.27 | Toxic epidermal necrolysis: an approach to management using cryopreserved allograft skin. ( Birchall, N; Cuono, C; Langdon, R; McGuire, J, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 35 (27.56) | 18.7374 |
| 1990's | 17 (13.39) | 18.2507 |
| 2000's | 28 (22.05) | 29.6817 |
| 2010's | 33 (25.98) | 24.3611 |
| 2020's | 14 (11.02) | 2.80 |
| Authors | Studies |
|---|---|
| Huang, PW | 1 |
| Chiou, MH | 1 |
| Chien, MY | 1 |
| Chen, WW | 1 |
| Chu, CY | 2 |
| Zheng, Y | 1 |
| Zhou, W | 2 |
| Guo, X | 1 |
| Chi, L | 1 |
| Chen, C | 1 |
| Guo, Z | 1 |
| Liang, J | 1 |
| Wei, L | 1 |
| Chen, X | 1 |
| Ye, X | 1 |
| He, J | 1 |
| Tee, CT | 1 |
| Abdullah, NH | 1 |
| Kristummoonthy, P | 1 |
| Lee, CS | 1 |
| Pinto, AR | 1 |
| Cunha, IM | 1 |
| Gomes, ER | 1 |
| Sukasem, C | 2 |
| Sririttha, S | 1 |
| Tempark, T | 1 |
| Klaewsongkram, J | 1 |
| Rerkpattanapipat, T | 2 |
| Puangpetch, A | 1 |
| Boongird, A | 1 |
| Chulavatnatol, S | 1 |
| Manuyakorn, W | 1 |
| Likkasittipan, P | 1 |
| Wattanapokayakit, S | 1 |
| Suvichapanich, S | 1 |
| Inunchot, W | 1 |
| Wichukchinda, N | 2 |
| Khongkhatithuml, C | 1 |
| Thampratankul, L | 1 |
| Kamchaisatian, W | 1 |
| Benjaponpitak, S | 1 |
| Mahasirimongkol, S | 2 |
| Noguchi, Y | 1 |
| Takaoka, M | 1 |
| Hayashi, T | 1 |
| Tachi, T | 1 |
| Teramachi, H | 1 |
| Karnes, JH | 1 |
| Rettie, AE | 1 |
| Somogyi, AA | 1 |
| Huddart, R | 1 |
| Fohner, AE | 1 |
| Formea, CM | 1 |
| Ta Michael Lee, M | 1 |
| Llerena, A | 1 |
| Whirl-Carrillo, M | 1 |
| Klein, TE | 1 |
| Phillips, EJ | 2 |
| Mintzer, S | 1 |
| Gaedigk, A | 1 |
| Caudle, KE | 1 |
| Callaghan, JT | 1 |
| Chung, SJ | 1 |
| Ahn, KM | 1 |
| Oh, JH | 1 |
| Shim, JS | 1 |
| Park, HW | 1 |
| Sabourirad, S | 1 |
| Mortezaee, R | 1 |
| Mojarad, M | 1 |
| Eslahi, A | 1 |
| Shahrokhi, Y | 1 |
| Kiafar, B | 1 |
| Jarahi, L | 1 |
| Afkhami Ardakani, S | 1 |
| Farrokhi, S | 1 |
| Fukasawa, T | 1 |
| Takahashi, H | 1 |
| Takahashi, K | 1 |
| Tanemura, N | 1 |
| Amagai, M | 1 |
| Urushihara, H | 1 |
| Sivagourounadin, K | 1 |
| Rajendran, P | 1 |
| Selvarajan, S | 1 |
| Ganesapandian, M | 1 |
| Rathinam, KK | 1 |
| Sabarathinam, S | 1 |
| Nuthalapati, P | 1 |
| Mahalingam, VT | 1 |
| Shukla, S | 1 |
| Rastogi, S | 1 |
| Abdi, SAH | 1 |
| Dhamija, P | 1 |
| Kumar, V | 1 |
| Kalaiselvan, V | 1 |
| Medhi, B | 1 |
| Sriganesh, K | 1 |
| Das, BP | 1 |
| Rao, KVLN | 1 |
| Devi, K | 1 |
| Wu, X | 1 |
| Liu, W | 1 |
| Syu, FK | 1 |
| Pan, HY | 1 |
| Chuang, PC | 1 |
| Huang, YS | 1 |
| Cheng, CY | 1 |
| Cheng, FJ | 1 |
| Kumkamthornkul, P | 1 |
| Udnaen, S | 1 |
| Tansit, T | 1 |
| Tuchinda, P | 1 |
| Srinoulprasert, Y | 1 |
| Limpawattana, P | 1 |
| Choonhakarn, C | 1 |
| Kongbunkiat, K | 1 |
| East-Innis, AD | 1 |
| Thompson, DS | 1 |
| Li, X | 1 |
| Yu, K | 1 |
| Mei, S | 1 |
| Huo, J | 1 |
| Wang, J | 1 |
| Zhu, Y | 1 |
| Zhao, Z | 1 |
| Chung, WH | 5 |
| Chang, WC | 1 |
| Lee, YS | 1 |
| Wu, YY | 1 |
| Yang, CH | 2 |
| Ho, HC | 1 |
| Chen, MJ | 1 |
| Lin, JY | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The BrainDrugs-Epilepsy Study: A Prospective Open-label Cohort Precision Medicine Study in Epilepsy[NCT05450822] | 550 participants (Anticipated) | Observational | 2022-02-18 | Recruiting | |||
| A Preliminary Study of the Efficacy and Safety of Carbamazepine in Severe Liver Disease Due to Alpha-1 Antitrypsin Deficiency[NCT01379469] | Phase 2 | 20 participants (Actual) | Interventional | 2012-01-31 | Terminated | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
8 reviews available for phenytoin and Stevens-Johnson Syndrome
| Article | Year |
|---|---|
Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2C9 and HLA-B Genotypes and Phenytoin Dosing: 2020 Update.
Topics: Alleles; Anticonvulsants; Cytochrome P-450 CYP2C9; Genetic Variation; Genotype; HLA-B Antigens; Huma | 2021 |
Association of CYP2C9*3 with phenytoin-induced Stevens-Johnson syndrome and toxic epidermal necrolysis: A systematic review and meta-analysis.
Topics: Alleles; Anticonvulsants; Cytochrome P-450 CYP2C9; Genetic Markers; Humans; Phenytoin; Stevens-Johns | 2018 |
HLA-B*1502 increases the risk of phenytoin or lamotrigine induced Stevens-Johnson Syndrome/toxic epidermal necrolysis: evidence from a meta-analysis of nine case-control studies.
Topics: Anticonvulsants; Case-Control Studies; Epilepsy; Genetic Predisposition to Disease; HLA-B15 Antigen; | 2015 |
Empact syndrome: a case report and review of the literature.
Topics: Anticonvulsants; Brain Neoplasms; Drug Eruptions; Epilepsy; Humans; Lung Neoplasms; Male; Middle Age | 2010 |
Is phenytoin contraindicated in patients receiving cranial irradiation?
Topics: Biopsy; Bone Neoplasms; Brain Neoplasms; Breast Neoplasms; Carcinoma; Combined Modality Therapy; Con | 1995 |
[Adverse cutaneous reactions to drugs in neurology].
Topics: Anticonvulsants; Drug Eruptions; Drug Hypersensitivity; Gingival Hyperplasia; Humans; Hypertrichosis | 1997 |
Increased risk of erythema multiforme major with combination anticonvulsant and radiation therapies.
Topics: Adult; Aged; Anticonvulsants; Brain Neoplasms; Combined Modality Therapy; Cranial Irradiation; Femal | 1999 |
[Allergological studies of the Lyell syndrome].
Topics: Adolescent; Adrenal Cortex Hormones; Adult; Aged; Ampicillin; Anti-Bacterial Agents; Female; Humans; | 1975 |
119 other studies available for phenytoin and Stevens-Johnson Syndrome
| Article | Year |
|---|---|
Analysis of severe cutaneous adverse reactions (SCARs) in Taiwan drug-injury relief system: 18-year results.
Topics: Allopurinol; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsants; Carbam | 2022 |
Drug-induced Stevens-Johnson syndrome: a disproportionality analysis from the pharmacovigilance database of the World Health Organization.
Topics: Allopurinol; Carbamazepine; Humans; Pharmacovigilance; Phenytoin; Retrospective Studies; Stevens-Joh | 2022 |
Severe cutaneous adverse reactions: A 5-year retrospective study at Hospital Melaka, Malaysia, from December 2014 to February 2020.
Topics: Acute Generalized Exanthematous Pustulosis; Adult; Allopurinol; Amoxicillin-Potassium Clavulanate Co | 2022 |
Phenytoin-Induced Toxic Epidermal Necrolysis in a Pediatric Patient.
Topics: Anticonvulsants; Child; Humans; Phenytoin; Stevens-Johnson Syndrome | 2023 |
Genetic and clinical risk factors associated with phenytoin-induced cutaneous adverse drug reactions in Thai population.
Topics: Anticonvulsants; Case-Control Studies; Female; Genetic Predisposition to Disease; Humans; Male; Midd | 2020 |
Association of HLA genotypes with phenytoin induced severe cutaneous adverse drug reactions in Thai children.
Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Drug Hypersensitivity Syndrome; Female; Geneti | 2020 |
Antiepileptic combination therapy with Stevens-Johnson syndrome and toxic epidermal necrolysis: Analysis of a Japanese pharmacovigilance database.
Topics: Anticonvulsants; Carbamazepine; Clobazam; Clonazepam; Databases, Factual; Drug Therapy, Combination; | 2020 |
Incidence rates of severe cutaneous adverse reactions due to antiseizure medication: A nationwide study using health claims data in Korea.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anticonvulsants; Carbamazepine; Child; Drug Hypersensiti | 2021 |
Investigating the association of Lamotrigine and Phenytoin-induced Stevens-Johnson syndrome/Toxic Epidermal Necrolysis with HLA-B*1502 in Iranian population.
Topics: Adult; Alleles; Anticonvulsants; Case-Control Studies; Female; HLA-B15 Antigen; Humans; Iran; Lamotr | 2021 |
Risk of Stevens-Johnson syndrome and toxic epidermal necrolysis associated with anticonvulsants in a Japanese population: Matched case-control and cohort studies.
Topics: Adult; Anticonvulsants; Carbamazepine; Case-Control Studies; Clonazepam; Cohort Studies; Diazepam; F | 2021 |
Agreement Among Different Scales for Causality Assessment in Drug-Induced Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsants; Humans; Phenytoin; Reproducibility of Resu | 2022 |
Phenytoin induced Stevens-Johnson Syndrome-toxic Epidermal Necrolysis Overlap Exacerbated by Cephalexin in a 65-Year-old Neurosurgical Patient: A Rare Case Report.
Topics: Aged; Cephalexin; Female; Humans; Necrosis; Phenytoin; Stevens-Johnson Syndrome | 2022 |
Severe cutaneous adverse reactions in Asians: Trends observed in culprit anti-seizure medicines using VigiBase®.
Topics: Adult; Anticonvulsants; Asian People; Female; Humans; Phenytoin; Retrospective Studies; Stevens-John | 2021 |
Toxic Epidermal Necrolysis in a Neurosurgical Patient.
Topics: Adult; Anti-Bacterial Agents; Anticonvulsants; Cefazolin; Fatal Outcome; Female; Humans; Intraoperat | 2018 |
The association of HLA B*15:02 allele and Stevens-Johnson syndrome/toxic epidermal necrolysis induced by aromatic anticonvulsant drugs in a South Indian population.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anticonvulsants; Carbamazepine; Case-Control Studies; Ch | 2018 |
Incidence of Stevens-Johnson syndrome following combination drug use of allopurinol, carbamazepine and phenytoin in Taiwan: A case-control study.
Topics: Adult; Aged; Allopurinol; Anticonvulsants; Carbamazepine; Case-Control Studies; Drug Combinations; E | 2018 |
Evaluation of a lymphocyte transformation test and cytokine detection assay to identify phenytoin and carbamazepine provoked DRESS or SJS/TEN in epilepsy patients.
Topics: Adult; Anticonvulsants; Carbamazepine; Cytokines; Drug Hypersensitivity Syndrome; Epilepsy; Female; | 2018 |
Clinical profiles of Stevens-Johnson syndrome among Thai patients.
Topics: Adolescent; Adult; Age Factors; Aged; Allopurinol; Female; Hepatitis; Humans; Male; Middle Aged; Phe | 2014 |
Stevens-Johnson syndrome and toxic epidermal necrolysis at the University Hospital of the West Indies, Jamaica.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Infective Agents; Anticonvulsants; Female; Hospital | 2013 |
Genetic variants associated with phenytoin-related severe cutaneous adverse reactions.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anticonvulsants; Aryl Hydrocarbon Hydroxylases; Case-Con | 2014 |
HLA-B∗ 1502 is associated with carbamazepine induced Stevens-Johnson syndrome in North Indian population.
Topics: Adult; Anticonvulsants; Carbamazepine; Case-Control Studies; Female; Gene Expression; HLA-B15 Antige | 2014 |
Toxic epidermal necrolysis in a patient receiving concurrent phenytoin and whole brain and thoracic radiotherapy.
Topics: Anticonvulsants; Brain Neoplasms; Carcinoma, Squamous Cell; Humans; Lung Neoplasms; Male; Middle Age | 2014 |
Genetic factors associated with severe cutaneous adverse reactions.
Topics: Anticonvulsants; Aryl Hydrocarbon Hydroxylases; Eosinophilia; Female; Humans; Male; Phenytoin; Steve | 2014 |
Genetic factors associated with severe cutaneous adverse reactions--reply.
Topics: Anticonvulsants; Aryl Hydrocarbon Hydroxylases; Eosinophilia; Female; Humans; Male; Phenytoin; Steve | 2014 |
Phenytoin induced toxic epidermal necrolysis.
Topics: Anticonvulsants; Carbamazepine; Drug Hypersensitivity; Humans; Male; Middle Aged; Phenytoin; Seizure | 2014 |
Risk of toxic epidermal necrolysis and Stevens-Johnson syndrome associated with benzodiazepines: a population-based cohort study.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Benzodiazepines; Child; Child, Preschool; Cohort Studies | 2015 |
Association of HLA-B*15:13 and HLA-B*15:02 with phenytoin-induced severe cutaneous adverse reactions in a Malay population.
Topics: Anticonvulsants; Case-Control Studies; Drug Hypersensitivity Syndrome; Female; Gene Frequency; Genet | 2017 |
Associations between HLA class I and cytochrome P450 2C9 genetic polymorphisms and phenytoin-related severe cutaneous adverse reactions in a Thai population.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Asian People; Cytochrome P-450 CYP2C9; Female; Genetic A | 2016 |
Causative Drugs of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in Israel.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anticonvulsants; Child; Child, Preschool; Female; Humans | 2017 |
Carbamazepine and phenytoin induced Stevens-Johnson syndrome is associated with HLA-B*1502 allele in Thai population.
Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Child; Epilepsy; Female; Genetic Predisposition t | 2008 |
Drug-associated linear IgA disease mimicking toxic epidermal necrolysis.
Topics: Anti-Bacterial Agents; Anticonvulsants; Diagnosis, Differential; Drug Eruptions; Fatal Outcome; Fema | 2009 |
Skin biopsies to assess response to systemic corticosteroid therapy in early-stage TEN: case report and review of the literature.
Topics: Adult; Anticonvulsants; Biopsy; Epilepsy, Tonic-Clonic; Female; Glucocorticoids; Humans; Methylpredn | 2009 |
Basic measures and systemic medical treatment of patients with toxic epidermal necrolysis.
Topics: Adult; Aged; Aged, 80 and over; Allopurinol; Anti-Bacterial Agents; Anti-Inflammatory Agents; Antico | 2010 |
Stevens-Johnson syndrome following concurrent phenytoin and holocranial radiotherapy.
Topics: Anti-Inflammatory Agents; Anticonvulsants; Antineoplastic Combined Chemotherapy Protocols; Brain Neo | 2010 |
Common risk allele in aromatic antiepileptic-drug induced Stevens-Johnson syndrome and toxic epidermal necrolysis in Han Chinese.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Alleles; Anticonvulsants; Asian People; Carbamazepine; C | 2010 |
Multifocal Stevens-Johnson syndrome after concurrent phenytoin and cranial and thoracic radiation treatment, a case report.
Topics: Anticonvulsants; Brain Neoplasms; Combined Modality Therapy; Cranial Irradiation; Humans; Male; Midd | 2010 |
Phenytoin-associated hypersensitivity syndrome with features of DRESS and TEN/SJS.
Topics: Anticonvulsants; Drug Eruptions; Drug Hypersensitivity; Eosinophilia; Female; Humans; Middle Aged; P | 2010 |
HLA-B*1502 genotyping in two Chinese patients with phenytoin-induced Stevens-Johnson syndrome.
Topics: Adult; Aged; Anticonvulsants; Asian People; Genotype; HLA-B Antigens; HLA-B35 Antigen; Humans; Male; | 2011 |
Phenytoin-induced Stevens-Johnson syndrome with negative HLA-B*1502 allele in mainland China: two cases.
Topics: Adult; Alleles; China; Female; Genetic Carrier Screening; Genetic Markers; HLA-B Antigens; HLA-B15 A | 2011 |
Phenytoin- and cranial radiotherapy-induced toxic epidermal necrolysis treated with combination therapy: systemic steroid and intravenous immunoglobulin.
Topics: Adenocarcinoma; Anti-Inflammatory Agents; Anticonvulsants; Brain Neoplasms; Combined Modality Therap | 2012 |
HLA-B*1502 screening and toxic effects of carbamazepine.
Topics: Anticonvulsants; Asian People; Carbamazepine; Drug-Related Side Effects and Adverse Reactions; HLA-B | 2011 |
Severe cutaneous adverse reactions to antiepileptic drugs in Asians.
Topics: Adult; Anticonvulsants; Asian People; Carbamazepine; Exanthema; Female; Follow-Up Studies; Humans; L | 2011 |
An insidious skin rash without itch.
Topics: Aged; Anticonvulsants; Exanthema; Female; Humans; Phenytoin; Pruritus; Stevens-Johnson Syndrome | 2012 |
Toxic epidermal necrolysis arising as a sequela of drug-induced hypersensitivity syndrome.
Topics: Anticonvulsants; Drug Hypersensitivity; Eosinophilia; Fatal Outcome; Humans; Male; Middle Aged; Mult | 2012 |
Cost-effectiveness of HLA-B*1502 genotyping in adult patients with newly diagnosed epilepsy in Singapore.
Topics: Adult; Alleles; Anticonvulsants; Asian People; Carbamazepine; Cost-Benefit Analysis; Decision Making | 2012 |
Phenytoin-induced Lyell's syndrome.
Topics: Anticonvulsants; Female; Humans; Middle Aged; Phenytoin; Stevens-Johnson Syndrome | 2012 |
Toxic epidermal necrolysis after phenytoin usage in a brain trauma patient.
Topics: Accidents, Traffic; Adult; Anesthesia, General; Anticonvulsants; Brain Edema; Brain Injuries; Critic | 2002 |
[Brain irradiation and phenytoin: a dangerous liaison?].
Topics: Adenocarcinoma; Adult; Aged; Anticonvulsants; Brain Neoplasms; Drug Eruptions; Female; Glioblastoma; | 2003 |
A fatal case of erythema multiforme exudativum (Stevens-Johnson's syndrome) following therapy with dilantin.
Topics: Drug Eruptions; Epilepsy; Epilepsy, Tonic-Clonic; Humans; Phenytoin; Seizures; Stevens-Johnson Syndr | 1962 |
[STEVENS-JOHNSON SYNDROME ASSOCIATED WITH IATROGENIC ANTICONVULSANT DRUG LYMPHADENOPATHY].
Topics: Adrenocorticotropic Hormone; Anticonvulsants; Child; Drug Therapy; Electroencephalography; Humans; I | 1964 |
TOXIC EPIDERMAL NECROLYSIS.
Topics: Amobarbital; Conjunctivitis; Drug Therapy; Humans; Isoniazid; Kanamycin; Phenytoin; Skin Diseases; S | 1964 |
TOXIC EPIDERMAL NECROLYSIS.
Topics: Alcoholism; Anti-Bacterial Agents; Chloramphenicol; Chlorpromazine; Drug Eruptions; Drug Therapy; Hu | 1965 |
Phenytoin-induced linear IgA dermatosis mimicking toxic epidermal necrolysis.
Topics: Biopsy, Needle; Diagnosis, Differential; Drug Eruptions; Female; Follow-Up Studies; Humans; Immunogl | 2003 |
Toxic epidermal necrolysis in patients receiving anticonvulsants and cranial irradiation: a risk to consider.
Topics: Anticonvulsants; Brain Neoplasms; Carcinoma, Non-Small-Cell Lung; Cranial Irradiation; Humans; Lung | 2004 |
Toxic epidermal necrolysis after cranial radiotherapy and phenytoin treatment.
Topics: Aged; Anticonvulsants; Brain Neoplasms; Carcinoma, Non-Small-Cell Lung; Combined Modality Therapy; C | 2004 |
Risk estimates for drugs suspected of being associated with Stevens-Johnson syndrome and toxic epidermal necrolysis: a case-control study.
Topics: Adult; Allopurinol; Analgesics, Non-Narcotic; Anticonvulsants; Antimetabolites; Carbamazepine; Case- | 2005 |
Risk of Stevens-Johnson syndrome and toxic epidermal necrolysis in new users of antiepileptics.
Topics: Anticonvulsants; Carbamazepine; Causality; Epilepsy; Germany; Humans; Incidence; Inpatients; Lamotri | 2005 |
EMPACT syndrome.
Topics: Anticonvulsants; Cranial Irradiation; Diagnosis, Differential; Erythema Multiforme; Female; Humans; | 2005 |
EMPACT syndrome.
Topics: Adrenal Cortex Hormones; Anticonvulsants; Brain Neoplasms; Bronchial Neoplasms; Drug Eruptions; Eryt | 2005 |
Life-threatening toxic epidermal necrolysis during voriconazole therapy for invasive aspergillosis after chemotherapy.
Topics: Adult; Anticonvulsants; Antifungal Agents; Antineoplastic Combined Chemotherapy Protocols; Aspergill | 2006 |
Stevens-Johnson syndrome in two patients treated with cranial irradiation and phenytoin.
Topics: Anticonvulsants; Brain Neoplasms; Cranial Irradiation; Humans; Male; Middle Aged; Phenytoin; Stevens | 2006 |
[Odinophagia and cutaneous lesions in patient with cerebral metastases].
Topics: Aged; Anticonvulsants; Back; Brain Neoplasms; Cyclosporine; Dermis; Epilepsy; Fatal Outcome; Humans; | 2006 |
Colonic involvement in Stevens-Johnson syndrome.
Topics: Adolescent; Anticonvulsants; Colitis; Diarrhea; Epilepsy, Tonic-Clonic; Humans; Male; Malnutrition; | 2006 |
Toxic epidermal necrolysis in a mother and fetus.
Topics: Adolescent; Anticonvulsants; Biopsy; Epilepsy; Female; Fetal Death; Fetus; Humans; Infectious Diseas | 2006 |
Association between HLA-B*1502 allele and antiepileptic drug-induced cutaneous reactions in Han Chinese.
Topics: Adolescent; Adult; Alleles; Anticonvulsants; Asian People; Carbamazepine; Case-Control Studies; Chil | 2007 |
Association between HLA-B*1502 allele and antiepileptic drug-induced cutaneous reactions in Han Chinese.
Topics: Adolescent; Adult; Alleles; Anticonvulsants; Asian People; Carbamazepine; Case-Control Studies; Chil | 2007 |
Association between HLA-B*1502 allele and antiepileptic drug-induced cutaneous reactions in Han Chinese.
Topics: Adolescent; Adult; Alleles; Anticonvulsants; Asian People; Carbamazepine; Case-Control Studies; Chil | 2007 |
Association between HLA-B*1502 allele and antiepileptic drug-induced cutaneous reactions in Han Chinese.
Topics: Adolescent; Adult; Alleles; Anticonvulsants; Asian People; Carbamazepine; Case-Control Studies; Chil | 2007 |
[Toxic epidermal necrolysis induced by phenytoin and whole brain radiotherapy].
Topics: Adenocarcinoma; Aged; Anticonvulsants; Brain Neoplasms; Breast Neoplasms; Combined Modality Therapy; | 2007 |
Erythema multiforme associated with prophylactic use of phenytoin during cranial radiation therapy.
Topics: Anticonvulsants; Brain Neoplasms; Breast Neoplasms; Carcinoma, Intraductal, Noninfiltrating; Cranial | 2008 |
[Toxic epidermal necrolysis. Epidermolysis necroticans combustiforme].
Topics: Child, Preschool; Exanthema; Humans; Male; Phenobarbital; Phenytoin; Stevens-Johnson Syndrome | 1967 |
Fatal toxic epidermal necrolysis following reexposure to phenytoin: a case report.
Topics: Aged; Epilepsies, Myoclonic; Humans; Male; Phenytoin; Stevens-Johnson Syndrome | 1983 |
Universal cutaneous depigmentation following phenytoin-induced toxic epidermal necrolysis.
Topics: Chemical and Drug Induced Liver Injury; Child; Female; Humans; Melanocytes; Nephritis, Interstitial; | 1984 |
Phenobarbital vs. phenytoin for grand mal epilepsy.
Topics: Adolescent; Age Factors; Anticonvulsants; Child; Child, Preschool; Drug Administration Schedule; Epi | 1980 |
Toxic epidermal necrolysis.
Topics: Adult; Female; Humans; Phenytoin; Stevens-Johnson Syndrome | 1982 |
Images in clinical medicine. Toxic epidermal necrolysis.
Topics: Adult; Humans; Male; Phenytoin; Stevens-Johnson Syndrome | 1995 |
The anticonvulsant hypersensitivity syndrome.
Topics: Adult; Anticonvulsants; Bronchial Diseases; Carbamazepine; Drug Eruptions; Drug Hypersensitivity; Fa | 1993 |
[Stevens Johnson syndrome and phenytoin].
Topics: Humans; Male; Middle Aged; Phenytoin; Stevens-Johnson Syndrome | 1994 |
[Drug-induced Stevens-Johnson syndrome in a patient with AIDS].
Topics: Acquired Immunodeficiency Syndrome; Humans; Male; Middle Aged; Phenytoin; Pyrimethamine; Stevens-Joh | 1993 |
Stevens-Johnson syndrome and epidermal necrolysis after administration of sodium phenytoin with cranial irradiation.
Topics: Adult; Brain Neoplasms; Cranial Irradiation; Glioblastoma; Humans; Male; Middle Aged; Phenytoin; Ste | 1993 |
Stevens-Johnson syndrome resulting from whole-brain radiation and phenytoin.
Topics: Anticonvulsants; Brain Neoplasms; Carcinoma, Squamous Cell; Chemoprevention; Cranial Irradiation; De | 1996 |
Phenytoin-induced toxic epidermal necrolysis: a case report.
Topics: Adult; Anticonvulsants; Eye Diseases; Humans; Male; Phenytoin; Stevens-Johnson Syndrome | 1996 |
Cyclophosphamide in the treatment of toxic epidermal necrolysis.
Topics: Adult; Anticonvulsants; Body Surface Area; Brain Neoplasms; Carcinoma, Non-Small-Cell Lung; Cyclopho | 1996 |
The case of the dire desquamation. Stevens-Johnson syndrome.
Topics: Aged; Anticonvulsants; Brain Neoplasms; Breast Neoplasms; Cranial Irradiation; Fatal Outcome; Female | 1998 |
Gelatinases in drug-induced toxic epidermal necrolysis.
Topics: Adult; Aged; Amoxicillin; Biopsy; Blister; Child, Preschool; Collagenases; Enzyme Activation; Female | 1998 |
Plasmapheresis as an adjunct treatment in toxic epidermal necrolysis.
Topics: Adolescent; Adult; Aged; Child, Preschool; Female; Humans; Male; Middle Aged; Phenytoin; Plasmaphere | 1999 |
Stevens-Johnson syndrome in patients on phenytoin and cranial radiotherapy.
Topics: Adult; Anticonvulsants; Combined Modality Therapy; Cranial Irradiation; Female; Humans; Male; Middle | 1999 |
Anticonvulsant-induced toxic epidermal necrolysis: monitoring the immunologic response.
Topics: Adult; Antibody Formation; Anticonvulsants; Blood Cells; Carbamazepine; CD3 Complex; Cytokines; E-Se | 2000 |
[Lyell's syndrome and its ophthalmologic manifestations in Cameroon].
Topics: Adolescent; Adult; Anti-Infective Agents; Anticonvulsants; Blindness; Cameroon; Child; Child, Presch | 2000 |
[Progressive, small spotted, confluent erythema with bullae formation and general symptoms. Acute Lyell syndrome].
Topics: Adult; Anticonvulsants; Diagnosis, Differential; Epilepsy; Humans; Male; Phenobarbital; Phenytoin; S | 2000 |
Management of drug-induced toxic epidermal necrolysis.
Topics: Adult; Anticonvulsants; Biopsy; Diagnosis, Differential; Female; Humans; Phenytoin; Skin; Stevens-Jo | 2000 |
Drug-induced linear IgA bullous dermatosis mimicking toxic epidermal necrolysis.
Topics: Aged; Anti-Bacterial Agents; Anticonvulsants; Diagnosis, Differential; Drug Eruptions; Humans; Immun | 2001 |
Anesthetic management of toxic epidermal necrolysis: report of three adult cases.
Topics: Adult; Anesthesia; Anti-Infective Agents; Anticonvulsants; Female; Humans; Male; Phenytoin; Stevens- | 2001 |
Stevens-Johnson syndrome in a patient receiving anticonvulsant therapy during cranial irradiation.
Topics: Adult; Anticonvulsants; Brain Neoplasms; Breast Neoplasms; Carcinoma, Ductal, Breast; Cranial Irradi | 2001 |
Successful dexamethasone pulse therapy in a toxic epidermal necrolysis (TEN) patient featuring recurrent TEN to oxazepam.
Topics: Anticonvulsants; Brain Neoplasms; Dexamethasone; Drug Therapy, Combination; Epidermis; Female; Gluco | 2001 |
Mucocutaneous eruptions due to antiepileptic drug therapy in children.
Topics: Anticonvulsants; Carbamazepine; Child; Child, Preschool; Erythema Multiforme; Female; Humans; Male; | 1979 |
Phenytoin-induced toxic epidermal necrolysis.
Topics: Aged; Humans; Male; Phenytoin; Stevens-Johnson Syndrome | 1979 |
Eruptive melanocytic naevi following severe bullous disease.
Topics: Child; Female; Humans; Male; Nevus, Pigmented; Phenobarbital; Phenytoin; Skin Neoplasms; Stevens-Joh | 1978 |
[Stevens-Johnson syndrome as an early allergic reaction to diphenylhydantoin].
Topics: Adult; Drug Hypersensitivity; Epilepsies, Partial; Humans; Male; Phenytoin; Stevens-Johnson Syndrome | 1976 |
[Toxic epidermal necrolosys -- Lyell's syndrome in a patient protractedly treated by anti-epileptic agents].
Topics: Adult; Anticonvulsants; Barbiturates; Epilepsy; Humans; Male; Mephenytoin; Phenobarbital; Phenytoin; | 1976 |
Acute (toxic) epidermal necrolysis. Report of a case.
Topics: Child, Preschool; Dextroamphetamine; Humans; Male; Mouth Diseases; Mouth Mucosa; Phenobarbital; Phen | 1975 |
Efficacy of cyclophosphamide in toxic epidermal necrolysis. Clinical and pathophysiologic aspects.
Topics: Adult; Aged; Allopurinol; Ampicillin; Basement Membrane; Cell Membrane; Chlorpropamide; Cyclophospha | 1991 |
Toxic epidermal necrolysis associated with diphenylhydantoin and cranial irradiation.
Topics: Adult; Female; Humans; Phenytoin; Radiotherapy; Stevens-Johnson Syndrome | 1991 |
Fatal phenytoin-related toxic epidermal necrolysis: case report.
Topics: Humans; Male; Middle Aged; Phenytoin; Stevens-Johnson Syndrome | 1989 |
Drug-induced toxic epidermal necrolysis treated with cyclosporin.
Topics: Adult; Cyclosporins; Female; Humans; Methylprednisolone; Phenytoin; Prednisone; Stevens-Johnson Synd | 1989 |
Widespread bullous fixed drug eruption mimicking toxic epidermal necrolysis.
Topics: Adult; Anti-Infective Agents; Diagnosis, Differential; Drug Combinations; Female; Humans; Male; Phen | 1988 |
Erythema multiforme and Stevens-Johnson syndrome in patients receiving cranial irradiation and phenytoin.
Topics: Adult; Brain Neoplasms; Dysgerminoma; Erythema Multiforme; Humans; Male; Phenytoin; Radiation Injuri | 1988 |
Survival after a second episode of toxic epidermal necrolysis.
Topics: Adult; Biological Dressings; Cephalothin; Hemorrhage; Humans; Male; Phenytoin; Pneumonia; Recurrence | 1988 |
Toxic epidermal necrolysis: an approach to management using cryopreserved allograft skin.
Topics: Cadaver; Child; Female; Freezing; Humans; Phenytoin; Skin; Skin Transplantation; Stevens-Johnson Syn | 1987 |
Phenytoin hypersensitivity reaction presenting with toxic epidermal necrolysis and severe hepatitis. Report of a patient treated with corticosteroid "pulse therapy".
Topics: Chemical and Drug Induced Liver Injury; Drug Hypersensitivity; Humans; Male; Methylprednisolone; Mid | 1985 |
Dilantin-induced erythema multiforme major: report of a case with liver and kidney involvement.
Topics: Adult; Chemical and Drug Induced Liver Injury; Female; Humans; Nephritis, Interstitial; Phenytoin; S | 1985 |
Toxic epidermal necrolysis due to antiepileptic therapy in an 8-year-old boy.
Topics: Adult; Anticonvulsants; Child; Diagnosis, Differential; Humans; Infant; Male; Phenytoin; Primidone; | 1985 |
Case report: psychosis with Stevens-Johnson syndrome and toxic epidermal necrolysis.
Topics: Adult; Basal Ganglia; Female; Humans; Phenobarbital; Phenytoin; Psychotic Disorders; Stevens-Johnson | 1985 |
Stevens-Johnson syndrome and toxic epidermal necrolysis in a patient with systemic lupus erythematosus.
Topics: Aged; Female; Humans; Lupus Erythematosus, Systemic; Phenytoin; Stevens-Johnson Syndrome; Tetracycli | 1985 |
Erythema multiforme exudativum (Stevens-Johnson syndrome) following sodium diphenylhydantoin therapy.
Topics: Adolescent; Age Factors; Atropine; Conjunctiva; Contact Lenses; Corneal Ulcer; Drug Combinations; Ey | 1971 |
Diphenylhydantoin.
Topics: Affective Symptoms; Arrhythmias, Cardiac; Ataxia; Carbamazepine; Central Nervous System Diseases; Ch | 1971 |
[Lymphocyte transformation test in drug hypersensitivity].
Topics: Ampicillin; Drug Hypersensitivity; Exanthema; Humans; Immunologic Techniques; Lymphocyte Activation; | 1972 |
Drugs for convulsions.
Topics: Adult; Child; Child, Preschool; Diazepam; Humans; Phenobarbital; Phenytoin; Seizures; Stevens-Johnso | 1973 |
Blood lymphoblast proliferation in vivo in cutaneous drug hypersensitivity reactions.
Topics: Blood Cell Count; Carbamazepine; Chlorpromazine; Drug Hypersensitivity; Exanthema; Humans; Lymphocyt | 1974 |
[The effect of hydantoinal on cardiac arrhythmias].
Topics: Acute Disease; Adolescent; Adult; Aged; Arrhythmias, Cardiac; Female; Humans; Male; Middle Aged; Phe | 1970 |
[Toxic epidermal necrolysis and staphyloccocal pleuropneumonia].
Topics: Adolescent; Anemia; Bronchopneumonia; Chorea; Female; Humans; Phenytoin; Pneumonia, Staphylococcal; | 1968 |
[Mucosal-cutaneous-ocular syndrome].
Topics: Child; Child, Preschool; Humans; Male; Phenytoin; Stevens-Johnson Syndrome; Sulfamethoxypyridazine | 1966 |