Page last updated: 2024-10-21

phenytoin and Spinal Cord Injuries

phenytoin has been researched along with Spinal Cord Injuries in 8 studies

Spinal Cord Injuries: Penetrating and non-penetrating injuries to the spinal cord resulting from traumatic external forces (e.g., WOUNDS, GUNSHOT; WHIPLASH INJURIES; etc.).

Research Excerpts

ExcerptRelevanceReference
" In this study we compared the therapeutic effects of HD on pressure ulcer healing with two other topical applications, phenytoin cream (PC) and simple dressing (SD)."9.11A randomized clinical trial comparing hydrocolloid, phenytoin and simple dressings for the treatment of pressure ulcers [ISRCTN33429693]. ( Hollisaz, MT; Khedmat, H; Yari, F, 2004)
" In this study we compared the therapeutic effects of HD on pressure ulcer healing with two other topical applications, phenytoin cream (PC) and simple dressing (SD)."5.11A randomized clinical trial comparing hydrocolloid, phenytoin and simple dressings for the treatment of pressure ulcers [ISRCTN33429693]. ( Hollisaz, MT; Khedmat, H; Yari, F, 2004)
"Phenytoin has a wide range of pharmacologic effects other than its anticonvulsant activity."3.75Phenytoin revisited. ( Finkel, MJ, 1984)
"It is well known that people with spinal cord injuries can develop hypothermia when exposed to an unusually cold environment."1.28Acute and chronic hypothermia in a man with spinal cord injury: environmental and pharmacologic causes. ( Hahn, G; Menard, MR, 1991)
"Dogs treated with phenytoin (PHT) were clinically superior to untreated controls when compared 6 weeks after injury."1.26Effect of phenytoin on functional recovery after experimental spinal cord injury in dogs. ( Gerber, AM; Harris, JH; Olson, WL, 1980)

Research

Studies (8)

TimeframeStudies, this research(%)All Research%
pre-19902 (25.00)18.7374
1990's1 (12.50)18.2507
2000's4 (50.00)29.6817
2010's1 (12.50)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Squair, JW1
Phillips, AA1
Harmon, M1
Krassioukov, AV1
Hains, BC1
Saab, CY1
Lo, AC1
Waxman, SG1
Hollisaz, MT1
Khedmat, H1
Yari, F1
Kaptanoglu, E1
Solaroglu, I1
Surucu, HS1
Akbiyik, F1
Beskonakli, E1
Ates, O1
Cayli, SR1
Gurses, I1
Turkoz, Y1
Tarim, O1
Cakir, CO1
Kocak, A1
Finkel, MJ1
Gerber, AM1
Olson, WL1
Harris, JH1
Menard, MR1
Hahn, G1

Clinical Trials (5)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Restoring Hemodynamic Stability Using Targeted Epidural Spinal Stimulation Following Spinal Cord Injury[NCT04994886]8 participants (Anticipated)Interventional2021-06-08Recruiting
The Effects of Spinal Cord Stimulation on Autonomic Function in People With Spinal Cord Injury[NCT03924388]46 participants (Anticipated)Interventional2020-02-01Not yet recruiting
Restoring Hemodynamic Stability Using Targeted Epidural Spinal Stimulation Following Spinal Cord Injury[NCT05044923]8 participants (Anticipated)Interventional2021-12-31Recruiting
Epidural Electrical Stimulation to Restore Hemodynamic Stability and Trunk Control in People With Spinal Cord Injury[NCT05111093]20 participants (Anticipated)Interventional2021-11-29Recruiting
Clinical Cohort Study of Association Between Steady State Phenytoin Treatment and Better Clinical Parameters of Glaucoma[NCT00739154]200 participants (Anticipated)Observational2008-11-30Not yet recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

1 review available for phenytoin and Spinal Cord Injuries

ArticleYear
Phenytoin revisited.
    Clinical therapeutics, 1984, Volume: 6, Issue:5

    Topics: Angina Pectoris; Animals; Arrhythmias, Cardiac; Cerebrovascular Disorders; Clinical Trials as Topic;

1984

Trials

2 trials available for phenytoin and Spinal Cord Injuries

ArticleYear
A randomized clinical trial comparing hydrocolloid, phenytoin and simple dressings for the treatment of pressure ulcers [ISRCTN33429693].
    BMC dermatology, 2004, Dec-15, Volume: 4, Issue:1

    Topics: Administration, Topical; Adult; Colloids; Humans; Male; Occlusive Dressings; Phenytoin; Pressure Ulc

2004
Phenytoin revisited.
    Clinical therapeutics, 1984, Volume: 6, Issue:5

    Topics: Angina Pectoris; Animals; Arrhythmias, Cardiac; Cerebrovascular Disorders; Clinical Trials as Topic;

1984

Other Studies

6 other studies available for phenytoin and Spinal Cord Injuries

ArticleYear
Emergency management of autonomic dysreflexia with neurologic complications.
    CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 2016, Oct-18, Volume: 188, Issue:15

    Topics: Anti-Bacterial Agents; Anticonvulsants; Antihypertensive Agents; Autonomic Dysreflexia; Brain; Consc

2016
Emergency management of autonomic dysreflexia with neurologic complications.
    CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 2016, Oct-18, Volume: 188, Issue:15

    Topics: Anti-Bacterial Agents; Anticonvulsants; Antihypertensive Agents; Autonomic Dysreflexia; Brain; Consc

2016
Emergency management of autonomic dysreflexia with neurologic complications.
    CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 2016, Oct-18, Volume: 188, Issue:15

    Topics: Anti-Bacterial Agents; Anticonvulsants; Antihypertensive Agents; Autonomic Dysreflexia; Brain; Consc

2016
Emergency management of autonomic dysreflexia with neurologic complications.
    CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 2016, Oct-18, Volume: 188, Issue:15

    Topics: Anti-Bacterial Agents; Anticonvulsants; Antihypertensive Agents; Autonomic Dysreflexia; Brain; Consc

2016
Emergency management of autonomic dysreflexia with neurologic complications.
    CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 2016, Oct-18, Volume: 188, Issue:15

    Topics: Anti-Bacterial Agents; Anticonvulsants; Antihypertensive Agents; Autonomic Dysreflexia; Brain; Consc

2016
Emergency management of autonomic dysreflexia with neurologic complications.
    CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 2016, Oct-18, Volume: 188, Issue:15

    Topics: Anti-Bacterial Agents; Anticonvulsants; Antihypertensive Agents; Autonomic Dysreflexia; Brain; Consc

2016
Emergency management of autonomic dysreflexia with neurologic complications.
    CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 2016, Oct-18, Volume: 188, Issue:15

    Topics: Anti-Bacterial Agents; Anticonvulsants; Antihypertensive Agents; Autonomic Dysreflexia; Brain; Consc

2016
Emergency management of autonomic dysreflexia with neurologic complications.
    CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 2016, Oct-18, Volume: 188, Issue:15

    Topics: Anti-Bacterial Agents; Anticonvulsants; Antihypertensive Agents; Autonomic Dysreflexia; Brain; Consc

2016
Emergency management of autonomic dysreflexia with neurologic complications.
    CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 2016, Oct-18, Volume: 188, Issue:15

    Topics: Anti-Bacterial Agents; Anticonvulsants; Antihypertensive Agents; Autonomic Dysreflexia; Brain; Consc

2016
Emergency management of autonomic dysreflexia with neurologic complications.
    CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 2016, Oct-18, Volume: 188, Issue:15

    Topics: Anti-Bacterial Agents; Anticonvulsants; Antihypertensive Agents; Autonomic Dysreflexia; Brain; Consc

2016
Emergency management of autonomic dysreflexia with neurologic complications.
    CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 2016, Oct-18, Volume: 188, Issue:15

    Topics: Anti-Bacterial Agents; Anticonvulsants; Antihypertensive Agents; Autonomic Dysreflexia; Brain; Consc

2016
Emergency management of autonomic dysreflexia with neurologic complications.
    CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 2016, Oct-18, Volume: 188, Issue:15

    Topics: Anti-Bacterial Agents; Anticonvulsants; Antihypertensive Agents; Autonomic Dysreflexia; Brain; Consc

2016
Emergency management of autonomic dysreflexia with neurologic complications.
    CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 2016, Oct-18, Volume: 188, Issue:15

    Topics: Anti-Bacterial Agents; Anticonvulsants; Antihypertensive Agents; Autonomic Dysreflexia; Brain; Consc

2016
Emergency management of autonomic dysreflexia with neurologic complications.
    CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 2016, Oct-18, Volume: 188, Issue:15

    Topics: Anti-Bacterial Agents; Anticonvulsants; Antihypertensive Agents; Autonomic Dysreflexia; Brain; Consc

2016
Emergency management of autonomic dysreflexia with neurologic complications.
    CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 2016, Oct-18, Volume: 188, Issue:15

    Topics: Anti-Bacterial Agents; Anticonvulsants; Antihypertensive Agents; Autonomic Dysreflexia; Brain; Consc

2016
Emergency management of autonomic dysreflexia with neurologic complications.
    CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 2016, Oct-18, Volume: 188, Issue:15

    Topics: Anti-Bacterial Agents; Anticonvulsants; Antihypertensive Agents; Autonomic Dysreflexia; Brain; Consc

2016
Sodium channel blockade with phenytoin protects spinal cord axons, enhances axonal conduction, and improves functional motor recovery after contusion SCI.
    Experimental neurology, 2004, Volume: 188, Issue:2

    Topics: Animals; Anticonvulsants; Axons; Behavior, Animal; Disease Models, Animal; Electrophysiology; Male;

2004
Blockade of sodium channels by phenytoin protects ultrastructure and attenuates lipid peroxidation in experimental spinal cord injury.
    Acta neurochirurgica, 2005, Volume: 147, Issue:4

    Topics: Animals; Disease Models, Animal; Lipid Peroxidation; Male; Malondialdehyde; Methylprednisolone; Neur

2005
Comparative neuroprotective effect of sodium channel blockers after experimental spinal cord injury.
    Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia, 2007, Volume: 14, Issue:7

    Topics: Animals; Behavior, Animal; Disease Models, Animal; Lipid Peroxidation; Locomotion; Male; Mexiletine;

2007
Effect of phenytoin on functional recovery after experimental spinal cord injury in dogs.
    Neurosurgery, 1980, Volume: 7, Issue:5

    Topics: Animals; Contusions; Dexamethasone; Dogs; Necrosis; Norepinephrine; Paraplegia; Phenytoin; Spinal Co

1980
Acute and chronic hypothermia in a man with spinal cord injury: environmental and pharmacologic causes.
    Archives of physical medicine and rehabilitation, 1991, Volume: 72, Issue:6

    Topics: Adult; Autonomic Nervous System; Body Temperature Regulation; Humans; Hypothermia; Male; Nifedipine;

1991