phenytoin has been researched along with Sensitivity and Specificity in 52 studies
Sensitivity and Specificity: Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Phenytoin is a widely used anti-seizure agent, and a good correlation is observed between its concentration in plasma and the clinical effect." | 5.36 | Determination of free and total levels of phenytoin in human plasma from patients with epilepsy by MEKC: an adequate alternative to HPLC. ( Chen, SH; Hsieh, YH; Liao, FF; Lin, PC, 2010) |
| "Sixty critically ill pediatric patients receiving phenytoin for treatment of seizures in a large multidisciplinary intensive care unit." | 3.73 | Total phenytoin concentrations do not accurately predict free phenytoin concentrations in critically ill children. ( Dodson, B; McClain, CD; McManus, ML; Wolf, GK; Zurakowski, D, 2006) |
| " the LTA by using trypan blue exclusion and to determine the utility of the assay to confirm drug hypersensitivity syndrome (DHS) to sulphonamides (SMX) and aromatic anticonvulsants." | 3.70 | A novel lymphocyte toxicity assay to assess drug hypersensitivity syndromes. ( Malkiewicz, IM; Neuman, MG; Shear, NH, 2000) |
| "972 patients with seizure disorder were recruited." | 2.69 | Single small enhancing CT lesion in Thai patients with acute symptomatic seizures: a clinico-radiological study. ( Mahuntussanapong, A; Yodnopaklow, P, 2000) |
| "Phenytoin is a widely used anti-seizure agent, and a good correlation is observed between its concentration in plasma and the clinical effect." | 1.36 | Determination of free and total levels of phenytoin in human plasma from patients with epilepsy by MEKC: an adequate alternative to HPLC. ( Chen, SH; Hsieh, YH; Liao, FF; Lin, PC, 2010) |
| "Phenytoin assays were evaluated using an additional set of samples from patients with abnormal renal function." | 1.31 | Performance characteristics of four immunoassays for antiepileptic drugs on the IMMULITE 2000 automated analyzer. ( Annesley, TM; Frank, EL; Juenke, J; Roberts, WL; Schwarz, EL, 2002) |
| "Free phenytoin levels were assessed using ultrafiltrates obtained with the Centrifree Microfiltration system (Amicon, Inc." | 1.30 | Adaptation of total phenytoin reagent pack for measuring free phenytoin levels with the Abbott AxSYM immunoassay analyzer. ( Jarzabek, JI; Kampa, IS, 1999) |
| "Mefenamic acid (MA) is a nonsteroidal antiinflammatory analgesic agent widely used clinically." | 1.28 | Rapid and sensitive liquid chromatographic assay of mefenamic acid in plasma. ( Cheymol, G; Lebot, M; Poirier, JM, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 16 (30.77) | 18.2507 |
| 2000's | 22 (42.31) | 29.6817 |
| 2010's | 14 (26.92) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Diamandis, P | 1 |
| Wildenhain, J | 1 |
| Clarke, ID | 1 |
| Sacher, AG | 1 |
| Graham, J | 1 |
| Bellows, DS | 1 |
| Ling, EK | 1 |
| Ward, RJ | 1 |
| Jamieson, LG | 1 |
| Tyers, M | 1 |
| Dirks, PB | 1 |
| Su, SC | 1 |
| Chen, CB | 1 |
| Chang, WC | 1 |
| Wang, CW | 1 |
| Fan, WL | 1 |
| Lu, LY | 1 |
| Nakamura, R | 1 |
| Saito, Y | 1 |
| Ueta, M | 1 |
| Kinoshita, S | 1 |
| Sukasem, C | 1 |
| Yampayon, K | 1 |
| Kijsanayotin, P | 1 |
| Nakkam, N | 1 |
| Saksit, N | 1 |
| Tassaneeyakul, W | 1 |
| Aihara, M | 1 |
| Lin, YJ | 1 |
| Chang, CJ | 1 |
| Wu, T | 1 |
| Hung, SI | 1 |
| Chung, WH | 1 |
| Garg, U | 1 |
| Peat, J | 1 |
| Frazee, C | 1 |
| Nguyen, T | 1 |
| Ferguson, AM | 1 |
| Tacker, DH | 1 |
| Robinson, R | 1 |
| Perrotta, PL | 1 |
| Deeb, S | 1 |
| McKeown, DA | 1 |
| Torrance, HJ | 1 |
| Wylie, FM | 1 |
| Logan, BK | 1 |
| Scott, KS | 1 |
| Villanelli, F | 1 |
| Giocaliere, E | 1 |
| Malvagia, S | 1 |
| Rosati, A | 1 |
| Forni, G | 1 |
| Funghini, S | 1 |
| Shokry, E | 1 |
| Ombrone, D | 1 |
| Della Bona, ML | 1 |
| Guerrini, R | 1 |
| la Marca, G | 1 |
| Mansor, S | 2 |
| Boellaard, R | 2 |
| Froklage, FE | 2 |
| Bakker, ED | 2 |
| Yaqub, M | 2 |
| Voskuyl, RA | 2 |
| Schwarte, LA | 2 |
| Verbeek, J | 2 |
| Windhorst, AD | 2 |
| Lammertsma, A | 1 |
| de Vries, A | 1 |
| Eriksson, J | 1 |
| Lammertsma, AA | 1 |
| Hoshina, K | 1 |
| Horiyama, S | 1 |
| Matsunaga, H | 1 |
| Haginaka, J | 1 |
| Lin, PC | 1 |
| Hsieh, YH | 1 |
| Liao, FF | 1 |
| Chen, SH | 1 |
| Rasetti-Escargueil, C | 1 |
| Liu, Y | 1 |
| Rigsby, P | 1 |
| Jones, RG | 1 |
| Sesardic, D | 1 |
| Tai, SS | 1 |
| Yeh, CY | 1 |
| Phinney, KW | 1 |
| Rani, S | 1 |
| Malik, AK | 1 |
| Singh, B | 1 |
| Bailey, HP | 1 |
| Rutan, SC | 1 |
| Stoll, DR | 1 |
| Iwaki, Y | 1 |
| Kawasaki, H | 1 |
| Arakawa, R | 1 |
| Barlag, RE | 1 |
| Halsall, HB | 1 |
| Heineman, WR | 1 |
| Frank, EL | 1 |
| Schwarz, EL | 1 |
| Juenke, J | 1 |
| Annesley, TM | 1 |
| Roberts, WL | 2 |
| El-Gindy, A | 1 |
| Emara, S | 1 |
| Hadad, GM | 1 |
| Su, W | 1 |
| Lin, Q | 1 |
| Song, Y | 1 |
| Pap, T | 1 |
| Horvai, G | 1 |
| Tutor-Crespo, MJ | 1 |
| Hermida, J | 1 |
| Tutor, JC | 1 |
| Casas, MN | 1 |
| Blanco, CC | 1 |
| Carretero, AS | 1 |
| Gutiérrez, AF | 1 |
| Patil, KM | 1 |
| Bodhankar, SL | 1 |
| Santagati, NA | 1 |
| Gotti, R | 1 |
| Ronsisvalle, G | 1 |
| Zhao, Y | 1 |
| Rui, JZ | 1 |
| Li, JH | 1 |
| Xiang, BR | 1 |
| Wolf, GK | 1 |
| McClain, CD | 1 |
| Zurakowski, D | 1 |
| Dodson, B | 1 |
| McManus, ML | 1 |
| Yang, X | 1 |
| Janatova, J | 1 |
| Juenke, JM | 1 |
| McMillin, GA | 1 |
| Andrade, JD | 1 |
| Vermeij, TA | 1 |
| Edelbroek, PM | 1 |
| Jinjuvadia, K | 1 |
| Kwan, W | 1 |
| Fontana, RJ | 1 |
| Queiroz, RH | 1 |
| Bertucci, C | 1 |
| Malfará, WR | 1 |
| Dreossi, SA | 1 |
| Chaves, AR | 1 |
| Valério, DA | 1 |
| Queiroz, ME | 1 |
| Naranjo, CA | 1 |
| Kwok, MC | 1 |
| Lanctôt, KL | 1 |
| Zhao, HP | 1 |
| Spielberg, SP | 1 |
| Shear, NH | 2 |
| Rainey, PM | 1 |
| Rogers, KE | 1 |
| Korolkiewicz, R | 1 |
| Kleinrok, Z | 1 |
| Mlynarczyk, M | 1 |
| Tanaka, E | 1 |
| Sakamoto, N | 1 |
| Inubushi, M | 1 |
| Misawa, S | 1 |
| Cwik, MJ | 1 |
| Liang, M | 1 |
| Deyo, K | 1 |
| Andrews, C | 1 |
| Fischer, J | 1 |
| Datta, P | 2 |
| Bhatti, MM | 1 |
| Hanson, GD | 1 |
| Schultz, L | 1 |
| Tomson, T | 1 |
| Sköld, AC | 1 |
| Holmgen, P | 1 |
| Nilsson, L | 1 |
| Danielsson, B | 1 |
| Ibach, B | 1 |
| Appel, K | 1 |
| Gebicke-Haerter, P | 1 |
| Meyer, RP | 1 |
| Friedberg, T | 1 |
| Knoth, R | 1 |
| Volk, B | 1 |
| Jarzabek, JI | 1 |
| Kampa, IS | 1 |
| Dasgupta, A | 1 |
| Vega, AE | 1 |
| Wells, A | 1 |
| Yodnopaklow, P | 1 |
| Mahuntussanapong, A | 1 |
| Bardin, S | 1 |
| Ottinger, JC | 1 |
| Breau, AP | 1 |
| O'Shea, TJ | 1 |
| Guan, F | 1 |
| Uboh, CE | 1 |
| Soma, LR | 1 |
| Birks, EK | 1 |
| Teleis, D | 1 |
| Rudy, JA | 1 |
| Watson, AO | 1 |
| Tsang, DS | 1 |
| Neuman, MG | 1 |
| Malkiewicz, IM | 1 |
| Yao, TW | 1 |
| Zeng, S | 1 |
| Radhakrishna, H | 1 |
| Park, JH | 1 |
| Oh, KH | 1 |
| Lee, DC | 1 |
| Kim, HS | 1 |
| Colbert, DL | 1 |
| Poirier, JM | 1 |
| Lebot, M | 1 |
| Cheymol, G | 1 |
| Jandreski, MA | 1 |
| Shah, JC | 1 |
| Garbincius, J | 1 |
| Bermes, EW | 1 |
| Schumacher, GE | 1 |
| Barr, JT | 1 |
| Browne, TR | 1 |
| Collins, JF | 1 |
1 review available for phenytoin and Sensitivity and Specificity
| Article | Year |
|---|---|
HLA Alleles and CYP2C9*3 as Predictors of Phenytoin Hypersensitivity in East Asians.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anticonvulsants; Asian People; Child; Child, Preschool; | 2019 |
3 trials available for phenytoin and Sensitivity and Specificity
| Article | Year |
|---|---|
Sensitive methods for determination of free digitoxin concentration using digitoxin immunoassays: demonstration of elevated free digitoxin concentration caused by digitoxin-phenytoin interaction by applying these new techniques.
Topics: Binding, Competitive; Blood Proteins; Cardiotonic Agents; Digitoxin; Drug Interactions; Fluorescence | 1999 |
Single small enhancing CT lesion in Thai patients with acute symptomatic seizures: a clinico-radiological study.
Topics: Adolescent; Adult; Anticonvulsants; Brain; Child; Female; Humans; Male; Middle Aged; Phenytoin; Seiz | 2000 |
Test performance characteristics of the serum phenytoin concentration (SPC): the relationship between SPC and patient response. The Veterans Administration Epilepsy Cooperative Study Group.
Topics: Double-Blind Method; False Negative Reactions; False Positive Reactions; Humans; Monitoring, Physiol | 1991 |
48 other studies available for phenytoin and Sensitivity and Specificity
| Article | Year |
|---|---|
Chemical genetics reveals a complex functional ground state of neural stem cells.
Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutic | 2007 |
A simple isotope dilution electrospray ionization tandem mass spectrometry method for the determination of free phenytoin.
Topics: Anticonvulsants; Chromatography, Liquid; Drug Stability; Drug Storage; Humans; Indicator Dilution Te | 2013 |
Abbott ARCHITECT iPhenytoin assay versus similar assays for measuring free phenytoin concentrations.
Topics: Anticonvulsants; Automation, Laboratory; Fluorescence Polarization; Humans; Immunoassay; Laboratory | 2014 |
Simultaneous analysis of 22 antiepileptic drugs in postmortem blood, serum and plasma using LC-MS-MS with a focus on their role in forensic cases.
Topics: Amines; Anticonvulsants; Carbamazepine; Chromatography, Liquid; Cyclohexanecarboxylic Acids; Drug Mo | 2014 |
Dried blood spot assay for the quantification of phenytoin using Liquid Chromatography-Mass Spectrometry.
Topics: Calibration; Chromatography, Liquid; Dried Blood Spot Testing; Drug Monitoring; Drug Stability; Huma | 2015 |
Quantification of Dynamic 11C-Phenytoin PET Studies.
Topics: Adult; Algorithms; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biomarkers; Carbon Radio | 2015 |
Parametric Methods for Dynamic
Topics: Adult; ATP Binding Cassette Transporter, Subfamily B, Member 1; Brain; Carbon Radioisotopes; Humans; | 2017 |
Molecularly imprinted polymers for simultaneous determination of antiepileptics in river water samples by liquid chromatography-tandem mass spectrometry.
Topics: Anticonvulsants; Barbiturates; Chromatography, Liquid; Drug Residues; Hydrogen-Ion Concentration; Mo | 2009 |
Determination of free and total levels of phenytoin in human plasma from patients with epilepsy by MEKC: an adequate alternative to HPLC.
Topics: Adult; Calibration; Chromatography, High Pressure Liquid; Chromatography, Micellar Electrokinetic Ca | 2010 |
Phrenic nerve-hemidiaphragm as a highly sensitive replacement assay for determination of functional botulinum toxin antibodies.
Topics: Animals; Botulinum Antitoxin; Diaphragm; Immunoassay; Immunologic Factors; Male; Mice; Mice, Inbred | 2011 |
Development and validation of a reference measurement procedure for certification of phenytoin, phenobarbital, lamotrigine, and topiramate in human serum using isotope-dilution liquid chromatography/tandem mass spectrometry.
Topics: Anticonvulsants; Chromatography, Reverse-Phase; Fructose; Humans; Indicator Dilution Techniques; Lam | 2011 |
Novel micro-extraction by packed sorbent procedure for the liquid chromatographic analysis of antiepileptic drugs in human plasma and urine.
Topics: Anticonvulsants; Carbamazepine; Chromatography, Liquid; Humans; Oxcarbazepine; Phenobarbital; Phenyt | 2012 |
Chemometric analysis of targeted 3DLC-DAD data for accurate and precise quantification of phenytoin in wastewater samples.
Topics: Anticonvulsants; Chromatography, Liquid; Phenytoin; Sensitivity and Specificity; Water Pollutants, C | 2012 |
Human serum albumin-modified Fe3O4 magnetic nanoparticles for affinity-SALDI-MS of small-molecule drugs in biological liquids.
Topics: Camptothecin; Ferrosoferric Oxide; Humans; Ibuprofen; Magnetite Nanoparticles; Molecular Weight; Phe | 2012 |
Amperometric homogeneous competitive immunoassay in a perfluorocarbon emulsion oxygen therapeutic (PEOT).
Topics: Anticonvulsants; Blood Substitutes; Bronchodilator Agents; Electrochemical Techniques; Enzyme Multip | 2013 |
Performance characteristics of four immunoassays for antiepileptic drugs on the IMMULITE 2000 automated analyzer.
Topics: Anticonvulsants; Carbamazepine; Chromatography, High Pressure Liquid; Cross Reactions; Drug Monitori | 2002 |
Determination of two ternary mixtures containing phenobarbitone by second derivative of the ratio spectrum-zero-crossing and HPLC methods.
Topics: Anticonvulsants; Chromatography, High Pressure Liquid; Mephobarbital; Papaverine; Phenobarbital; Phe | 2003 |
[Establishment of ELISA for measuring phenytoin in serum].
Topics: Chromatography, High Pressure Liquid; Enzyme-Linked Immunosorbent Assay; Humans; Phenytoin; Sensitiv | 2000 |
Characterization of the selectivity of a phenytoin imprinted polymer.
Topics: Chromatography; Phenytoin; Polymers; Sensitivity and Specificity | 2004 |
Activation of serum aminotransferases by pyridoxal-5' -phosphate in epileptic patients treated with anticonvulsant drugs.
Topics: Adult; Alanine Transaminase; Aspartate Aminotransferases; Carbamazepine; Drug Therapy, Combination; | 2004 |
Simple and rapid micellar electrokinetic capillary chromatographic method for simultaneous determination of four antiepileptics in human serum.
Topics: Anticonvulsants; Buffers; Carbamazepine; Chromatography, Micellar Electrokinetic Capillary; Ethosuxi | 2004 |
Simultaneous determination of lamotrigine, phenobarbitone, carbamazepine and phenytoin in human serum by high-performance liquid chromatography.
Topics: Carbamazepine; Chromatography, High Pressure Liquid; Humans; Lamotrigine; Phenobarbital; Phenytoin; | 2005 |
Simultaneous determination of phenytoin and dextromethorphan in urine by solid-phase extraction and HPLC-DAD.
Topics: Anticonvulsants; Antitussive Agents; Chromatography, High Pressure Liquid; Dextromethorphan; Humans; | 2005 |
[Rapid analysis of antiepileptic drugs in human plasma by micellar electrokinetic capillary chromatography].
Topics: Anticonvulsants; Buffers; Carbamazepine; Chromatography, Micellar Electrokinetic Capillary; Clonazep | 2006 |
Total phenytoin concentrations do not accurately predict free phenytoin concentrations in critically ill children.
Topics: Adolescent; Adult; Anti-Bacterial Agents; Anticonvulsants; Blood Chemical Analysis; Cefazolin; Child | 2006 |
An ImmunoChip prototype for simultaneous detection of antiepileptic drugs using an enhanced one-step homogeneous immunoassay.
Topics: Anticonvulsants; Carbamazepine; Humans; Immunoassay; Phenytoin; Reagent Kits, Diagnostic; Sensitivit | 2007 |
Robust isocratic high performance liquid chromatographic method for simultaneous determination of seven antiepileptic drugs including lamotrigine, oxcarbazepine and zonisamide in serum after solid-phase extraction.
Topics: Analysis of Variance; Animals; Anticonvulsants; Carbamazepine; Cattle; Chromatography, High Pressure | 2007 |
Searching for a needle in a haystack: use of ICD-9-CM codes in drug-induced liver injury.
Topics: Adolescent; Adult; Aged; Amoxicillin-Potassium Clavulanate Combination; Chemical and Drug Induced Li | 2007 |
Quantification of carbamazepine, carbamazepine-10,11-epoxide, phenytoin and phenobarbital in plasma samples by stir bar-sorptive extraction and liquid chromatography.
Topics: Carbamazepine; Chromatography, High Pressure Liquid; Drug Monitoring; Humans; Phenobarbital; Phenyto | 2008 |
Enhanced differential diagnosis of anticonvulsant hypersensitivity reactions by an integrated Bayesian and biochemical approach.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Bayes Theorem; Carbamazepine; Cell Death; Child; Diagnosis | 1994 |
Metabolite and matrix interference in phenytoin immunoassays.
Topics: Calibration; Enzyme Multiplied Immunoassay Technique; Fluorescence Polarization; Humans; Immunoassay | 1996 |
Intracerebroventricular pertussis toxin enhances sensitivity to chemical convulsants and decreases the protective efficacy of carbamazepine in mice.
Topics: Animals; Anticonvulsants; Carbamazepine; Convulsants; Diazepam; Drug Synergism; GTP-Binding Proteins | 1996 |
Simultaneous determination of plasma phenytoin and its primary hydroxylated metabolites in carbon tetrachloride-intoxicated rats by high-performance liquid chromatography.
Topics: Animals; Anticonvulsants; Carbon Tetrachloride; Chromatography, High Pressure Liquid; Male; Phenytoi | 1995 |
Simultaneous rapid high-performance liquid chromatographic determination of phenytoin and its prodrug, fosphenytoin in human plasma and ultrafiltrate.
Topics: Anticonvulsants; Chromatography, High Pressure Liquid; Humans; Phenytoin; Prodrugs; Sensitivity and | 1997 |
Oxaprozin and 5-(p-hydroxyphenyl)-5-phenylhydantoin interference in phenytoin immunoassays.
Topics: Antibodies, Monoclonal; Cross Reactions; Humans; Immunoassay; Oxaprozin; Phenytoin; Propionates; Rea | 1997 |
Simultaneous determination of phenytoin, carbamazepine, and 10,11-carbamazepine epoxide in human plasma by high-performance liquid chromatography with ultraviolet detection.
Topics: Carbamazepine; Chromatography, High Pressure Liquid; Humans; Phenytoin; Sensitivity and Specificity; | 1998 |
Postmortem changes in blood concentrations of phenytoin and carbamazepine: an experimental study.
Topics: Animals; Anticonvulsants; Carbamazepine; Death, Sudden; Epilepsy; Humans; Phenytoin; Postmortem Chan | 1998 |
Effect of phenytoin on cytochrome P450 2B mRNA expression in primary rat astrocyte cultures.
Topics: Alternative Splicing; Animals; Anticonvulsants; Aryl Hydrocarbon Hydroxylases; Astrocytes; Cells, Cu | 1998 |
Adaptation of total phenytoin reagent pack for measuring free phenytoin levels with the Abbott AxSYM immunoassay analyzer.
Topics: Evaluation Studies as Topic; Humans; Immunoassay; Phenytoin; Reagent Kits, Diagnostic; Sensitivity a | 1999 |
Determination of free levels of phenytoin in human plasma by liquid chromatography/tandem mass spectrometry.
Topics: Anticonvulsants; Chromatography, Liquid; Hemolysis; Humans; Mass Spectrometry; Phenytoin; Reproducib | 2000 |
Quantification of phenytoin and its metabolites in equine plasma and urine using high-performance liquid chromatography.
Topics: Animals; Calibration; Chromatography, High Pressure Liquid; Horses; Phenytoin; Reproducibility of Re | 2000 |
A novel lymphocyte toxicity assay to assess drug hypersensitivity syndromes.
Topics: Adolescent; Adult; Aged; Animals; Anticonvulsants; Carbamazepine; Case-Control Studies; Cell Surviva | 2000 |
Stereoselective determination of p-hydroxyphenyl-phenylhydantoin enantiomers in rat liver microsomal incubates by reversed-phase high-performance liquid chromatography using beta-cyclodextrin as chiral mobile phase additives.
Topics: Animals; beta-Cyclodextrins; Chromatography, High Pressure Liquid; Cyclodextrins; Male; Microsomes, | 2001 |
Appeal for uniformity in the dosage formulations.
Topics: Chemistry, Pharmaceutical; Dosage Forms; Drug Labeling; Humans; Phenytoin; Sensitivity and Specifici | 1998 |
Modeling and kinetic analysis of the reaction system using whole cells with separately and co-expressed D-hydantoinase and N-carbamoylase.
Topics: Agrobacterium tumefaciens; Amidohydrolases; Catalysis; Computer Simulation; Geobacillus stearothermo | 2002 |
Measurement of phenytoin in serum using in-house reagents employing the Syva enzyme-multiplied immunoassay technique principle.
Topics: Antibodies; Drug Stability; Enzyme Multiplied Immunoassay Technique; Humans; Phenytoin; Reagent Kits | 1992 |
Rapid and sensitive liquid chromatographic assay of mefenamic acid in plasma.
Topics: Carbamazepine; Chromatography, Liquid; Clonazepam; Humans; Hydrogen-Ion Concentration; Indomethacin; | 1992 |
Clinical evaluation of five therapeutic drugs using dry film multilayer technology on the OPUS immunoassay system.
Topics: Carbamazepine; Evaluation Studies as Topic; Humans; Immunoassay; Pharmaceutical Preparations; Phenob | 1991 |