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phenytoin and Psychotic Disorders

phenytoin has been researched along with Psychotic Disorders in 33 studies

Psychotic Disorders: Disorders in which there is a loss of ego boundaries or a gross impairment in reality testing with delusions or prominent hallucinations. (From DSM-IV, 1994)

Research Excerpts

ExcerptRelevanceReference
" Another six days later, she developed breakthrough seizures associated with subtherapeutic serum phenytoin levels."7.80Ciprofloxacin eye drops-induced subtherapeutic serum phenytoin levels resulting in breakthrough seizures. ( Liew, EK; Malladi, SS; Ng, XT; Tan, RK, 2014)
" This study demonstrated that the potent cytochrome P450 enzyme-inducer phenytoin did indeed have a marked effect on the metabolism of quetiapine, resulting in a 5-fold increase in clearance when administered concomitantly to patients with DSM-IV-diagnosed schizophrenia, schizoaffective disorder, or bipolar disorder."5.09The effects of concomitant phenytoin administration on the steady-state pharmacokinetics of quetiapine. ( Thyrum, PT; Wong, YW; Yeh, C, 2001)
" Another six days later, she developed breakthrough seizures associated with subtherapeutic serum phenytoin levels."3.80Ciprofloxacin eye drops-induced subtherapeutic serum phenytoin levels resulting in breakthrough seizures. ( Liew, EK; Malladi, SS; Ng, XT; Tan, RK, 2014)
" Two cases in which the addition of phenytoin caused a decrease in plasma clozapine concentrations and worsening of psychoses are described, and possible explanations are discussed."3.68Effect of phenytoin on plasma clozapine concentrations in two patients. ( Miller, DD, 1991)
" Their psychiatric interest stems from evidence of an inhibiting effect of certain substances, such as carbamazepine or phenytoin, which are effective in the treatment of both epilepsy and mental disorders, but this effect is also found for lithium (Post et al."3.67Kindling models and antikindling effects of mood normalizers. ( Azorin, JM; Tramoni, V, 1987)
"A second case of severe limb malformations was observed following maternal use of haloperidol early in the first trimester of pregnancy."3.65Limb malformations following maternal use of haloperidol. ( Heggeness, L; McCullar, FW, 1975)
"Agents introduced for the treatment of epilepsy have also been usedsimultaneously for psychiatric indications."2.43[Anticonvulsants treatment of psychiatric disorder in elderly patients]. ( Bidzan, L, 2006)
"We have observed acute dystonias in the absence of antipsychotic treatment and in the context of seizure activity (or paroxysmal dyskinetic activity)."1.33High vulnerability to acute dystonic reactions: a case of antipsychotic exposure and uncontrolled seizure activity. ( Botts, SR; Coffey, GL; de Leon, J, 2005)
"The bioavailability of dexamethasone (DEX) has recently been demonstrated to be a critical factor in determining Dexamethasone Suppression Test (DST) status in psychiatric patients."1.27Dexamethasone bioavailability: implications for DST research. ( Lowy, MT; Meltzer, HY, 1987)
"Patient compliance can be improved by reducing the complexity of drug dosage and by better labeling, packaging and informational exchange."1.26Once-a-day drug regimen for psychiatric patients. ( Hasan, MK; Mooney, RP, 1981)

Research

Studies (33)

TimeframeStudies, this research(%)All Research%
pre-199019 (57.58)18.7374
1990's2 (6.06)18.2507
2000's7 (21.21)29.6817
2010's5 (15.15)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Naha, S1
Naha, K1
Hande, HM1
Vivek, G1
Malladi, SS1
Liew, EK1
Ng, XT1
Tan, RK1
Nixon, AC1
Doak, MW1
Crozier, H1
Crooks, DP1
Waring, WS1
Lin, KH1
Chen, YJ1
Lin, YT1
Hsueh, WC1
Lu, CL1
Yen, MH1
Liao, KC1
KUBANEK, JL1
ROWELL, RC1
Arai, M1
Osaka, H1
Noguchi, T1
Fukatsu, N1
Kato, H1
Oshima, T1
Kanemoto, K1
JANZ, D1
KAUTZ, G1
BARSA, JA1
SAUNDERS, JC1
WILHOIT, WM1
Abu-Kishk, I1
Toledano, M1
Reis, A1
Daniel, D1
Berkovitch, M1
Coffey, GL1
Botts, SR1
de Leon, J1
Bidzan, L1
Kulkarni, J1
McCauley-Elsom, K1
Marston, N1
Gilbert, H1
Gurvich, C1
de Castella, A1
Fitzgerald, P1
Hasan, MK1
Mooney, RP1
Surman, OS1
Parker, SW1
Sperner, J1
Sander, B1
Lau, S1
Krude, H1
Scheffner, D1
Mishory, A1
Yaroslavsky, Y1
Bersudsky, Y1
Belmaker, RH1
Wong, YW1
Yeh, C1
Thyrum, PT1
Fisher, D1
DiMino, JM1
McCullar, FW1
Heggeness, L1
Miller, DD1
Azorin, JM1
Tramoni, V1
Lowy, MT1
Meltzer, HY1
de Rego, JA1
Goldstein, DM1
Chien, C1
Keegan, D1
Yaryura-Tobias, JA1
Klein, DF1
Andreasen, PB1
Heshe, J1
Bourgeois, M2
Vincent, JD2
Favarel-Garrigues, B2
Reynolds, EH1
Jensen, ON1
Olesen, OV1

Reviews

1 review available for phenytoin and Psychotic Disorders

ArticleYear
[Anticonvulsants treatment of psychiatric disorder in elderly patients].
    Przeglad lekarski, 2006, Volume: 63, Issue:7

    Topics: Aged; Anticonvulsants; Anxiety Disorders; Bipolar Disorder; Carbamazepine; Epilepsy; Humans; Mental

2006

Trials

3 trials available for phenytoin and Psychotic Disorders

ArticleYear
Phenytoin as an antimanic anticonvulsant: a controlled study.
    The American journal of psychiatry, 2000, Volume: 157, Issue:3

    Topics: Anticonvulsants; Antimanic Agents; Bipolar Disorder; Brief Psychiatric Rating Scale; Double-Blind Me

2000
The effects of concomitant phenytoin administration on the steady-state pharmacokinetics of quetiapine.
    Journal of clinical psychopharmacology, 2001, Volume: 21, Issue:1

    Topics: Adolescent; Adult; Analysis of Variance; Anticonvulsants; Antipsychotic Agents; Bipolar Disorder; Di

2001
Discussion of psychotropic effect of diphenylhydantoin (DPH).
    International journal of neuropsychiatry, 1967, Volume: 3

    Topics: Clinical Trials as Topic; Humans; Phenytoin; Placebos; Psychotic Disorders

1967

Other Studies

29 other studies available for phenytoin and Psychotic Disorders

ArticleYear
A young woman with seizures and psychosis.
    BMJ case reports, 2014, Jul-09, Volume: 2014

    Topics: Adult; Anticonvulsants; Epilepsy; Female; Hallucinations; Humans; Levetiracetam; Neuropsychological

2014
Ciprofloxacin eye drops-induced subtherapeutic serum phenytoin levels resulting in breakthrough seizures.
    Singapore medical journal, 2014, Volume: 55, Issue:7

    Topics: Administration, Oral; Aged, 80 and over; Anti-Bacterial Agents; Ciprofloxacin; Drug Interactions; Ep

2014
Patterns of antiepileptic drug overdose differ between men and women: admissions to the Edinburgh Poisons Unit, 2000-2007.
    QJM : monthly journal of the Association of Physicians, 2009, Volume: 102, Issue:1

    Topics: Adult; Anticonvulsants; Carbamazepine; Drug Overdose; Female; Humans; Lamotrigine; Male; Middle Aged

2009
Serious generalized tonic-clonic seizures induced by aripiprazole.
    Progress in neuro-psychopharmacology & biological psychiatry, 2010, Feb-01, Volume: 34, Issue:1

    Topics: Adult; Anticonvulsants; Antipsychotic Agents; Aripiprazole; Humans; Male; Phenytoin; Piperazines; Ps

2010
The use of dilantin in the treatment of psychotic patients unresponsive to other treatment.
    Diseases of the nervous system, 1946, Volume: 7

    Topics: Humans; Mental Disorders; Phenytoin; Psychotic Disorders

1946
Acute leukoencephalopathy possibly induced by phenytoin intoxication in an adult patient with methylenetetrahydrofolate reductase deficiency.
    Epilepsia, 2011, Volume: 52, Issue:7

    Topics: Anticonvulsants; Brain; Homocystinuria; Humans; Leukoencephalopathies; Magnetic Resonance Imaging; M

2011
Impact of antiepileptic drugs on genesis of psychosis.
    Epilepsy & behavior : E&B, 2012, Volume: 23, Issue:4

    Topics: Adolescent; Adult; Anticonvulsants; Epilepsy, Complex Partial; Female; Follow-Up Studies; Humans; In

2012
[ETIOLOGY AND THERAPY OF STATUS EPILEPTICUS].
    Deutsche medizinische Wochenschrift (1946), 1963, Nov-08, Volume: 88

    Topics: Abortion, Septic; Anticonvulsants; Birth Injuries; Brain Injuries; Brain Neoplasms; Chloral Hydrate;

1963
BENZQUINAMIDE IN THE TREATMENT OF PSYCHOTIC PATIENTS.
    Diseases of the nervous system, 1964, Volume: 25

    Topics: Chlorpromazine; Chlorprothixene; Drug Therapy; Humans; Mental Disorders; Phenytoin; Psychotic Disord

1964
THE BROADER TREATMENT OF ACUTE ALCOHOLISM AND DELIRIUM TREMENS.
    The Journal of the Florida Medical Association. Florida Medical Association, 1965, Volume: 52

    Topics: Alcohol Withdrawal Delirium; Alcoholism; Chlorpromazine; Drug Therapy; Humans; Phenytoin; Psychoses,

1965
Neuroleptic malignant syndrome in a child treated with an atypical antipsychotic.
    Journal of toxicology. Clinical toxicology, 2004, Volume: 42, Issue:6

    Topics: Acute Disease; Anticonvulsants; Antipsychotic Agents; Benzodiazepines; Blood Cell Count; Child; Dibe

2004
High vulnerability to acute dystonic reactions: a case of antipsychotic exposure and uncontrolled seizure activity.
    Progress in neuro-psychopharmacology & biological psychiatry, 2005, Volume: 29, Issue:5

    Topics: Anticonvulsants; Antipsychotic Agents; Chronic Disease; Cytochrome P-450 CYP2D6; Dibenzothiazepines;

2005
Preliminary findings from the National Register of Antipsychotic Medication in Pregnancy.
    The Australian and New Zealand journal of psychiatry, 2008, Volume: 42, Issue:1

    Topics: Adult; Antipsychotic Agents; Australia; Benzodiazepines; Chlorpromazine; Cross-Sectional Studies; Da

2008
Once-a-day drug regimen for psychiatric patients.
    American family physician, 1981, Volume: 24, Issue:4

    Topics: Adult; Antidepressive Agents; Antipsychotic Agents; Anxiety; Depressive Disorder; Drug Administratio

1981
Complex partial seizures and psychiatric disturbance in end-stage renal disease.
    Psychosomatics, 1981, Volume: 22, Issue:12

    Topics: Acute Kidney Injury; Adult; Anticonvulsants; Electroencephalography; Female; Humans; Methyldopa; Phe

1981
Severe transitory encephalopathy with reversible lesions of the claustrum.
    Pediatric radiology, 1996, Volume: 26, Issue:11

    Topics: Aphasia; Basal Ganglia Diseases; Blindness; Child; Deafness; Epilepsies, Myoclonic; Epilepsy; Epilep

1996
Case presentation of an alternative therapeutic approach for the borderline psychotic heroin addict: diphenylhydantoin.
    The British journal of addiction to alcohol and other drugs, 1975, Volume: 70, Issue:1

    Topics: Adult; Cognition Disorders; Heroin Dependence; Humans; Male; Phenytoin; Psychotherapy; Psychotic Dis

1975
Limb malformations following maternal use of haloperidol.
    JAMA, 1975, Jan-06, Volume: 231, Issue:1

    Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Drug Therapy, Combination; Female; Fetus; Halo

1975
Effect of phenytoin on plasma clozapine concentrations in two patients.
    The Journal of clinical psychiatry, 1991, Volume: 52, Issue:1

    Topics: Adult; Clozapine; Drug Interactions; Drug Therapy, Combination; Female; Humans; Male; Phenytoin; Psy

1991
Kindling models and antikindling effects of mood normalizers.
    Pharmacopsychiatry, 1987, Volume: 20, Issue:5

    Topics: Animals; Cats; Diethylcarbamazine; Electric Stimulation; Epilepsy; Humans; Kindling, Neurologic; Lit

1987
Dexamethasone bioavailability: implications for DST research.
    Biological psychiatry, 1987, Volume: 22, Issue:3

    Topics: Biological Availability; Carbamazepine; Cushing Syndrome; Depressive Disorder; Dexamethasone; Humans

1987
Case report: psychosis with Stevens-Johnson syndrome and toxic epidermal necrolysis.
    The Hillside journal of clinical psychiatry, 1985, Volume: 7, Issue:2

    Topics: Adult; Basal Ganglia; Female; Humans; Phenobarbital; Phenytoin; Psychotic Disorders; Stevens-Johnson

1985
Diazepam as an oral long-term anticonvulsant for epileptic mental patients.
    Diseases of the nervous system, 1972, Volume: 33, Issue:2

    Topics: Amobarbital; Anticonvulsants; Diazepam; Epilepsy; Evaluation Studies as Topic; Female; Humans; Long-

1972
Behavioral-gluco-dysrhythmic triad.
    The American journal of psychiatry, 1973, Volume: 130, Issue:7

    Topics: Brain; Diet Therapy; Electroencephalography; Glucose Tolerance Test; Humans; Hypoglycemia; Phenytoin

1973
[Neuropsychiatric manifestations of systemic lupus erythematosus].
    Nordisk psykiatrisk tidsskrift. Nordic journal of psychiatry, 1969, Volume: 23, Issue:5

    Topics: Adult; Chlorpromazine; Chlorprothixene; Female; Humans; Lupus Erythematosus, Systemic; Neurologic Ma

1969
[Oniropriva psychoses and their biologic treatment].
    Annales medico-psychologiques, 1969, Volume: 127, Issue:5

    Topics: Adjustment Disorders; Amphetamine; Antidepressive Agents; Barbiturates; Dreams; Electroconvulsive Th

1969
[Oniropriva psychoses and their biologic treatment].
    Annales medico-psychologiques, 1969, Volume: 1, Issue:5

    Topics: Adjustment Disorders; Amphetamine; Antidepressive Agents; Barbiturates; Dreams; Electroconvulsive Th

1969
Mental effects of anticonvulsants, and folic acid metabolism.
    Brain : a journal of neurology, 1968, Volume: 91, Issue:2

    Topics: Age Factors; Anemia, Macrocytic; Anticonvulsants; Brain; Epilepsy; Female; Folic Acid; Folic Acid De

1968
Folic acid and anticonvulsive drugs.
    Archives of neurology, 1969, Volume: 21, Issue:2

    Topics: Adolescent; Adult; Anticonvulsants; Epilepsy; Erythrocyte Count; Female; FIGLU Test; Folic Acid; Fol

1969