phenytoin has been researched along with Pregnancy in 757 studies
Pregnancy: The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To confirm whether 7 days of phenytoin, an enzyme inducer, would decrease the elimination half-life of single-dose nevirapine and to investigate its effect on the development of nevirapine resistance in pregnant, HIV-infected women." | 9.17 | Effect of 7 days of phenytoin on the pharmacokinetics of and the development of resistance to single-dose nevirapine for perinatal HIV prevention: a randomized pilot trial. ( Aitken, S; Burger, DM; Chunda, C; Fillekes, Q; Gibb, DM; Kankasa, C; Kisanga, ER; Muro, EP; Thomason, MJ; Walker, AS, 2013) |
| " This paper aims to undertake a comprehensive review regarding the possible risks of four classical (phenytoin, carbamazepine, phenobarbital, and valproate) and two newer (lamotrigine and levetiracetam) AEDs during pregnancy." | 9.12 | Use of Phenytoin, Phenobarbital Carbamazepine, Levetiracetam Lamotrigine and Valproate in Pregnancy and Breastfeeding: Risk of Major Malformations, Dose-dependency, Monotherapy vs Polytherapy, Pharmacokinetics and Clinical Implications. ( Demir, O; Kaplan, YC, 2021) |
| "Fifty pregnant women admitted with diagnosis of eclampsia were randomly allocated to magnesium sulphate (Group A) or phenytoin sodium (Group B) treatment group." | 9.09 | Efficacy of magnesium sulphate and phenytoin in the management of eclampsia. ( Mandal, R; Sawhney, H; Sawhney, IM; Vasishta, K, 1999) |
| "Women with a singleton pregnancy in vertex presentation between 32 and 42 weeks' gestation who required induction of labor for either preeclampsia, preeclampsia superimposed on chronic hypertension, or transient hypertension were randomized to receive either magnesium sulfate or phenytoin (Dilantin) for seizure prophylaxis." | 9.08 | Does magnesium sulfate affect the length of labor induction in women with pregnancy-associated hypertension? ( Atkinson, MW; Guinn, D; Hauth, JC; Owen, J, 1995) |
| " Anticonvulsant prophylaxis with phenytoin for eclampsia has been recommended, but there are virtually no data to support its efficacy." | 9.08 | A comparison of magnesium sulfate with phenytoin for the prevention of eclampsia. ( Cunningham, FG; Leveno, KJ; Lucas, MJ, 1995) |
| "To assess maternal middle cerebral artery flow velocity patterns as measured by transcranial Doppler ultrasound (TCD) in eclampsia and to investigate the effect of the anticonvulsants magnesium sulphate (MgSO4) and phenytoin on cerebral circulation." | 9.08 | Randomised study assessing the effect of phenytoin and magnesium sulphate on maternal cerebral circulation in eclampsia using transcranial Doppler ultrasound. ( Gouws, E; Hoffmann, M; Moodley, J; Naidu, S; Payne, AJ, 1996) |
| "Our objective was to evaluate the patterns of malformations in children exposed in utero to phenytoin (DPH) and carbamazepine (CBZ) monotherapy, and to compare them prospectively with matched mother-child pairs exposed to nonteratogens, and to separate the effects of antiepileptic drugs (AEDs) from those of epilepsy by collecting groups of untreated epileptics and those treated with DPH and CBZ for conditions other than epilepsy." | 9.08 | Findings in children exposed in utero to phenytoin and carbamazepine monotherapy: independent effects of epilepsy and medications. ( Chitayat, D; Farkas, LD; Koren, G; Nulman, I; Scolnik, D, 1997) |
| "The purpose of this study was to determine whether magnesium sulfate given for prevention of eclampsia affected labor outcomes compared with phenytoin, which is not known to impede uterine activity when given in anticonvulsant doses." | 9.08 | Does magnesium sulfate given for prevention of eclampsia affect the outcome of labor? ( Alexander, JM; Leveno, KJ; Lucas, MJ; McIntire, DD, 1998) |
| "Twenty-two patients with eclampsia were randomly allocated to receive either intravenous phenytoin sodium or intravenous magnesium sulphate." | 9.06 | Phenytoin sodium and magnesium sulphate in the management of eclampsia. ( Dommisse, J, 1990) |
| "The objective of this review was to assess the effects of magnesium sulphate compared with phenytoin when used for the care of women with eclampsia." | 8.86 | Magnesium sulphate versus phenytoin for eclampsia. ( Chou, D; Duley, L; Henderson-Smart, DJ, 2010) |
| "The objective of this review was to assess the effects of magnesium sulphate compared with phenytoin when used for the care of women with eclampsia." | 8.82 | Magnesium sulphate versus phenytoin for eclampsia. ( Duley, L; Henderson-Smart, D, 2003) |
| "The objective of this review was to assess the effects of magnesium sulphate compared with phenytoin when used for the care of women with eclampsia." | 8.80 | Magnesium sulphate versus phenytoin for eclampsia. ( Duley, L; Henderson-Smart, D, 2000) |
| "We evaluated the causality of the association between intrauterine exposure to phenytoin and postnatal neuroblastoma using an in vitro lymphocyte toxicity assay for phenytoin-induced reactions in an unusual sibship." | 8.77 | Neuroblastoma after prenatal exposure to phenytoin: cause and effect? ( Demitrakoudis, D; Koren, G; Rieder, M; Shandling, B; Shear, NH; Sonely, M; Spielberg, SP; Weksberg, R, 1989) |
| "This study was carried out to determine changes over time in use of folic acid, anti-epileptic drugs (AED), seizures during pregnancy and malformation rate over two decades in women with epilepsy enrolled in the Kerala registry of Epilepsy and Pregnancy (KREP)." | 7.96 | Anti-epileptic drug and folic acid usage during pregnancy, seizure and malformation outcomes: Changes over two decades in the Kerala Registry of Epilepsy and Pregnancy. ( A S, R; Baishya, J; Jose, M; Keni, RR; Sankara Sarma, P; Thomas, SV, 2020) |
| " We studied congenital abnormalities following exposure to phenytoin, phenobarbital, and diazepam in early pregnancy, i." | 7.74 | Use of phenytoin, phenobarbital, or diazepam during pregnancy and risk of congenital abnormalities: a case-time-control study. ( Christensen, J; Czeizel, AE; Horvath-Puhó, E; Kjaer, D; Olsen, J; Sørensen, HT; Vestergaard, M, 2007) |
| "Our previous genome-wide Quantitative Trait Locus (QTL) mapping study using mouse A/J by C57BL/6J recombinant inbred (RI) lines suggested several chromosomal regions contain genes influencing susceptibility to phenytoin (PT)-induced cleft lip with or without cleft palate [CL(P)] and 6-aminonicotinamide (6-AN)-induced isolated cleft palate (CP)." | 7.73 | Correlation of susceptibility to 6-aminonicotinamide and hydrocortisone-induced cleft palate. ( Diehl, SR; Erickson, RP; Karolyi, IJ, 2005) |
| "There are many reports that the teratogenic effects of phenytoin, especially cleft palate can be decreased by stimulation of maternal immune system." | 7.73 | A comparison study of effects of Echinacea extract and levamisole on phenytoin-induced cleft palate in mice. ( Arzi, A; Khaksary Mahabady, M; Najafzadeh, H; Papahn, AA; Ranjbar, R, 2006) |
| "The aim of the present study was to test the hypothesis that the natural antioxidant melatonin (MEL) and the synthetic antioxidant stobadine (STO) could reduce the incidence of maternal and embryofoetal toxicity in rats due to intrauterine hypoxia." | 7.72 | Effect of melatonin and stobadine on maternal and embryofoetal toxicity in rats due to intrauterine hypoxia induced by phenytoin administration. ( Brucknerová, I; Dubovický, M; Juránek, I; Mach, M; Navarová, J; Soltés, L; Ujházy, E; Zeman, M, 2004) |
| " The boy was exposed to phenytoin, in combination with carbamazepine, during pregnancy." | 7.71 | Chondrodysplasia punctata (CDP) with features of the tibia-metacarpal type and maternal phenytoin treatment during pregnancy. ( Annerén, G; Brandberg, G; Larsson, M; Lönnerholm, T; Wester, U, 2002) |
| "Urinary excretions of carbamazepine, carbamazepine-10,11-epoxide, carbamazepine-10,11-trans-diol, 9-hydroxyacridan and 2- and 3-hydroxycarbamazepine were measured at various stages of pregnancy, and in the post-natal period, in ten epileptic women, six of whom took no other enzyme-inducing anticonvulsant and four of whom took such co-medication." | 7.69 | Metabolism of carbamazepine and co-administered anticonvulsants during pregnancy. ( Bernus, I; Dickinson, RG; Eadie, MJ; Hooper, WD, 1995) |
| "The expression and ligand binding characteristics of sigma-receptors in human placental syncytiotrophoblast and choriocarcinoma cells were investigated using haloperidol as a ligand." | 7.69 | Cocaine-sensitive sigma-receptor and its interaction with steroid hormones in the human placental syncytiotrophoblast and in choriocarcinoma cells. ( Ganapathy, V; Leibach, FH; Mahesh, VB; Ramamoorthy, JD; Ramamoorthy, S, 1995) |
| "Phenytoin serum concentrations were evaluated in 88 epileptic women at different stages of pregnancy and 40 women during postnatal periods." | 7.69 | Phenytoin serum concentration monitoring during pregnancy and puerperium in Mexican epileptic women. ( Amancio-Chassin, O; Belmont-Gómez, A; Estrada-Altamirano, A; Hernández-Serrano, M; Herrerías-Cunedo, T; Rodríguez-Palomares, C, 1995) |
| "The aim of this study was to investigate if phenytoin has the capacity to induce embryonic hypoxia mediated via adverse effects on the embryonic heart." | 7.69 | Initiation of phenytoin teratogenesis: pharmacologically induced embryonic bradycardia and arrhythmia resulting in hypoxia and possible free radical damage at reoxygenation. ( Azarbayjani, F; Danielsson, BR; Sköld, AC; Webster, WS, 1997) |
| "To determine plasma phenytoin levels and seizure outcome in women given phenytoin for seizure prophylaxis in severe pre-eclampsia and eclampsia." | 7.68 | Phenytoin prophylaxis in severe pre-eclampsia and eclampsia. ( Campbell, M; de Swiet, M; Redfern, N; Robson, SC; Rodeck, C; Seviour, J; Walkinshaw, S, 1993) |
| "To investigate the efficacy of phenytoin in relation to total and free serum levels in patients with severe pre-eclampsia and eclampsia." | 7.68 | The efficacy of phenytoin in relation to serum levels in severe pre-eclampsia and eclampsia. ( Botha, J; McFadyen, L; Moodley, J; Naidu, S, 1992) |
| "The steady-state 72 h urinary excretion of various phenytoin metabolites has been measured in 10 epileptic women, whose plasma phenytoin concentrations relative to the phenytoin dose fell during pregnancy and rose again post-partum." | 7.68 | Phenytoin metabolism during pregnancy. ( Dickinson, RG; Eadie, MJ; Hooper, WD; Lander, CM; McKinnon, GE, 1992) |
| "Phenytoin sodium was administered intravenously as a single 900 mg dose in 33 consecutive women with eclampsia immediately on admission." | 7.68 | Single high dose of intravenous phenytoin sodium for the treatment of eclampsia. ( Coyaji, KJ; Otiv, SR, 1990) |
| "Five epileptic women needing to commence phenytoin therapy during pregnancy received a single intravenous and a single oral dose of phenytoin several days apart before starting regular intake of the drug." | 7.67 | Bioavailability and pharmacokinetics of phenytoin during pregnancy. ( Chalk, JB; de Wytt, C; Eadie, MJ; Lander, CM; Livingstone, I; Smith, MT; Symoniw, P, 1984) |
| "The purposes of this investigation were to determine the effect of pregnancy on the susceptibility of female rats to experimentally induced seizures and on the relationship between serum phenytoin concentration and antiseizure activity." | 7.67 | Kinetics of drug action in disease states III: Effect of pregnancy on the relationship between phenytoin concentration and antiseizure activity in rats. ( Chou, RC; Levy, G, 1984) |
| "The toxic interaction of caffeine and phenytoin during pregnancy was investigated in mice of the ICR strain on E10 of gestation." | 7.67 | The toxicology of chemical interactions during pregnancy in the mouse: caffeine and phenytoin. ( Kwasigroch, TE; Poche, PD; Skalko, RG, 1984) |
| "Both phenytoin (PHT) and glucocorticoid (GC) have been reported to be an effective teratogen for the production of cleft palate." | 7.67 | The relation between phenytoin-receptor and glucocorticoid in the induction of cleft palate with phenytoin in mice. ( Inayoshi, K; Kurisu, K; Nagata, K; Ohsaki, Y, 1989) |
| " To investigate the mechanism of the fall in steady-state plasma phenytoin concentration relative to drug dose that occurs during pregnancy, single dose pharmacokinetic studies with stable isotope labelled phenytoin were carried out at different stages of pregnancy, and 2 to 4 months post-natally, in five epileptic women receiving regular oral therapy with the drug." | 7.67 | The effect of pregnancy in humans on the pharmacokinetics of stable isotope labelled phenytoin. ( Dickinson, RG; Eadie, MJ; Hooper, WD; Lander, CM; Wood, B, 1989) |
| "Intravenous phenytoin sodium was given as a high-dose infusion (10 X 8-18 mg/kg) for anticonvulsive prophylaxis to 2 eclamptic patients and to 24 patients with moderate to severe pre-eclampsia." | 7.67 | Phenytoin infusion in severe pre-eclampsia. ( Anderton, JM; D'Souza, SW; Donnai, P; Mawer, GE; Patrick, J; Richardson, T; Slater, RM; Smith, WD; Wilcox, FL, 1987) |
| "Phenytoin administered to pregnant mice during the critical embryonic period of palatal differentiation produced 50% cleft palates in the Ajax (A/J) strain compared to 1." | 7.66 | Susceptibility of mice to phenytoin-induced cleft palate correlated with inhibition of fetal palatal RNA and protein synthesis (41255). ( Goldman, AS; Sonawane, BR, 1981) |
| "The authors studied antipyrine disposition before and after delivery in 4 epileptic women whose anticonvulsant plasma level per dosage ratio was lowered during pregnancy, and compared the results to those found in nonpregnant women undergoing antiepileptic treatment (N = 6) and healthy women (N = 6)." | 7.66 | Antipyrine disposition in relation to lowered anticonvulsant plasma level during pregnancy. ( Chiba, K; Ishizaki, T; Nakazawa, Y; Tabuchi, T; Wagatsuma, T, 1982) |
| "Pregnant female mice of various congenic strains were injected on days 11 through 14 of gestation with phenytoin, and the fetuses were examined for the occurrence of cleft palate." | 7.66 | Susceptibility to phenytoin-induced cleft palate in mice is influenced by genes linked to H-2 and H-3. ( Baker, MK; Gasser, DL; Goldman, AS, 1983) |
| "1 The effect of pregnancy on the binding of phenytoin and phenobarbitone to serum proteins was studied in normal women and in drug treated epileptic women." | 7.66 | Serum protein binding and free concentration of phenytoin and phenobarbitone in pregnancy. ( Chen, SS; Lee, JN; Perucca, E; Richens, A, 1982) |
| "Blood levels of phenytoin, total thyroxine, and free thyroxine were determined in 10 epileptic women during and following pregnancy." | 7.66 | Epilepsy and pregnancy. Serum thyroxine levels during phenytoin therapy. ( Ramsay, RE; Spellacy, WN; Strauss, RG; Wilder, BJ; Willmore, LJ, 1979) |
| "High incidences of cleft lip and palate (CLP) produced by maternal intraperitoneal administration of 75 mg/kg phenytoin on gestational day 10 to A/J mice are associated with a severe size reduction in the lateral nasal process." | 7.66 | Phenytoin (dilantin)-induced cleft lip and palate in A/J mice: a scanning and transmission electron microscopic study. ( Ambrose, LJ; Dorgan, D; Johnston, MC; Sulik, KK, 1979) |
| "Malignant mesenchymoma developed in an 18-year-old patient with phenytoin-associated cleft lip and palate." | 7.65 | Malignant mesenchymoma and birth defects. Prenatal exposure to phenytoin. ( Blattner, WA; Fraumeni, JF; Henson, DE; Young, RC, 1977) |
| "The objective of this study was to assess the feasibility of giving phenytoin to a group of mild preeclamptic women in a universal dosing scheme comparable to that typical of magnesium sulfate administration." | 6.67 | A simplified phenytoin regimen for preeclampsia. ( Cunningham, FG; DePalma, RT; Leveno, KJ; Lucas, MJ; Person, D; Peters, MT, 1994) |
| "Phenytoin is a well-tolerated alternative to magnesium sulfate for seizure prophylaxis in the patient with mild pregnancy-induced hypertension." | 6.67 | Magnesium sulfate versus phenytoin for seizure prophylaxis in pregnancy-induced hypertension. ( Adams, HR; Appleton, MP; Gold, WR; Knight, AB; Kuehl, TJ; Raebel, MA, 1991) |
| "Phenytoin has been widely prescribed alone; our results indicate that sodium valproate may also be used as a single drug in the treatment of several types of epilepsy." | 6.65 | Comparison of sodium valproate and phenytoin as single drug treatment in epilepsy. ( Johnson, RH; Lambie, DG; Melville, ID; Nanda, RN; Shakir, RA, 1981) |
| "Phenobarbital was associated with a higher rate of drug withdrawal although there was no evidence to suggest that phenobarbital caused more adverse events compared to carbamazepine, valproic acid or phenytoin." | 6.47 | Side effects of phenobarbital in epilepsy: a systematic review. ( Li, YP; Zeng, LN; Zhang, LL, 2011) |
| "Eclamptic seizures are clinically and electroencephalographically indistinguishable from generalized tonic-clonic seizures." | 6.38 | A continuing controversy: magnesium sulfate in the treatment of eclamptic seizures. ( Fisher, RS; Hanley, DF; Kaplan, PW; Lesser, RP; Repke, JT, 1990) |
| "The pathogenesis of eclamptic convulsions is unknown." | 6.38 | Magnesium sulfate is the ideal anticonvulsant in preeclampsia-eclampsia. ( Sibai, BM, 1990) |
| "PHT dose-dependently increased the hypoxia staining (6- and 11-fold after maternal dosing of 100 and 150 mg/kg, respectively) during the period I(Kr) is expressed and functional (GD 10)." | 5.33 | Phenytoin teratogenicity: hypoxia marker and effects on embryonic heart rhythm suggest an hERG-related mechanism. ( Azarbayjani, F; Blomgren, B; Danielsson, BR; Danielsson, C; Johansson, A; Sköld, AC, 2005) |
| " Embryonic heart rate was also recorded on individual days after dosing days 9-16." | 5.31 | Phenytoin-induced cleft palate: evidence for embryonic cardiac bradyarrhythmia due to inhibition of delayed rectifier K+ channels resulting in hypoxia-reoxygenation damage. ( Azarbayjani, F; Danielsson, BR, 2001) |
| " In this prospective, descriptive study four dosage regimens were investigated in 104 patients." | 5.28 | Clinical experience with phenytoin prophylaxis in severe preeclampsia. ( Lange, IR; Naugler, MA; Ryan, G, 1989) |
| "Pregnant women with epilepsy on one or more of the following AEDs: lamotrigine, carbamazepine, phenytoin or levetiracetam." | 5.27 | AntiEpileptic drug Monitoring in PREgnancy (EMPiRE): a double-blind randomised trial on effectiveness and acceptability of monitoring strategies. ( Bagary, M; Coleman, J; D'Amico, M; Denny, E; Dodds, J; Eldridge, S; Greenhill, L; Hard, K; Kelso, A; Khan, KS; Marlin, N; McCorry, D; Middleton, L; Moss, N; Newton, S; Pirie, A; Pullen, A; Rikunenko, R; Roberts, T; Rogozińska, E; Thangaratinam, S; Weckesser, A, 2018) |
| " In the first experiment, the lower end of the malformation dose-response curves for diphenylhydantoin (DPH), trimethadione (TMD) and phenobarbital (PB) were established." | 5.27 | Fetal anticonvulsant syndrome in rats: dose- and period-response relationships of prenatal diphenylhydantoin, trimethadione and phenobarbital exposure on the structural and functional development of the offspring. ( Vorhees, CV, 1983) |
| "Phenobarbital may cause hyperactivity, behavioral problems, sedation, and even dementia; these effects are dose related to some extent." | 5.27 | Side effects of phenobarbital and phenytoin during long-term treatment of epilepsy. ( Iivanainen, M; Savolainen, H, 1983) |
| " In 48% of the patients the drug dosage had to be increased to combat the increased seizure frequency." | 5.27 | Serum phenytoin during pregnancy, labor and puerperium. ( Bardy, AH; Hiilesmaa, VK; Teramo, KA, 1987) |
| "Electroconvulsive seizures administered during the period of fetal benzodiazepine (BZ) binding site proliferation (days 16, 18 and 20 in gestation) significantly decreased the density of cerebral cortical benzodiazepine binding sites in exposed pups up to 21 days postnatal age." | 5.26 | Prenatal exposure to electroconvulsive seizures and phenytoin: development of benzodiazepine binding sites, reflex behaviors and seizure thresholds in exposed offspring. ( Gallager, DW; Wakeman, EA, 1982) |
| " Within the therapeutic range, small increments in dosage resulted in large increments in plasma DPH levels, and in the postpartum period high levels of DPH were encountered if the dosage was not reduced." | 5.26 | Phenytoin metabolism in pregnancy. ( Emery, MG; Kochenour, NK; Sawchuk, RJ, 1980) |
| " Although phenytoin dosage remained relatively constant, plasma phenytoin concentrations during pregnancy were significantly lower than nonpregnant concentrations." | 5.26 | Hematologic effects of phenytoin therapy during pregnancy. ( Ramsay, RE; Strauss, RG; Wilder, BJ; Willmore, LJ, 1978) |
| "To confirm whether 7 days of phenytoin, an enzyme inducer, would decrease the elimination half-life of single-dose nevirapine and to investigate its effect on the development of nevirapine resistance in pregnant, HIV-infected women." | 5.17 | Effect of 7 days of phenytoin on the pharmacokinetics of and the development of resistance to single-dose nevirapine for perinatal HIV prevention: a randomized pilot trial. ( Aitken, S; Burger, DM; Chunda, C; Fillekes, Q; Gibb, DM; Kankasa, C; Kisanga, ER; Muro, EP; Thomason, MJ; Walker, AS, 2013) |
| "In this prospective, observational, assessor-masked, multicentre study, we enrolled pregnant women with epilepsy on antiepileptic drug monotherapy (carbamazepine, lamotrigine, phenytoin, or valproate) between October, 1999, and February, 2004, at 25 epilepsy centres in the UK and the USA." | 5.17 | Fetal antiepileptic drug exposure and cognitive outcomes at age 6 years (NEAD study): a prospective observational study. ( Baker, GA; Bromley, RL; Browning, N; Clayton-Smith, J; Cohen, MJ; Kalayjian, LA; Kanner, A; Liporace, JD; Loring, DW; Meador, KJ; Pennell, PB; Privitera, M, 2013) |
| " This paper aims to undertake a comprehensive review regarding the possible risks of four classical (phenytoin, carbamazepine, phenobarbital, and valproate) and two newer (lamotrigine and levetiracetam) AEDs during pregnancy." | 5.12 | Use of Phenytoin, Phenobarbital Carbamazepine, Levetiracetam Lamotrigine and Valproate in Pregnancy and Breastfeeding: Risk of Major Malformations, Dose-dependency, Monotherapy vs Polytherapy, Pharmacokinetics and Clinical Implications. ( Demir, O; Kaplan, YC, 2021) |
| "Fifty pregnant women admitted with diagnosis of eclampsia were randomly allocated to magnesium sulphate (Group A) or phenytoin sodium (Group B) treatment group." | 5.09 | Efficacy of magnesium sulphate and phenytoin in the management of eclampsia. ( Mandal, R; Sawhney, H; Sawhney, IM; Vasishta, K, 1999) |
| "Women with a singleton pregnancy in vertex presentation between 32 and 42 weeks' gestation who required induction of labor for either preeclampsia, preeclampsia superimposed on chronic hypertension, or transient hypertension were randomized to receive either magnesium sulfate or phenytoin (Dilantin) for seizure prophylaxis." | 5.08 | Does magnesium sulfate affect the length of labor induction in women with pregnancy-associated hypertension? ( Atkinson, MW; Guinn, D; Hauth, JC; Owen, J, 1995) |
| " Anticonvulsant prophylaxis with phenytoin for eclampsia has been recommended, but there are virtually no data to support its efficacy." | 5.08 | A comparison of magnesium sulfate with phenytoin for the prevention of eclampsia. ( Cunningham, FG; Leveno, KJ; Lucas, MJ, 1995) |
| "To assess maternal middle cerebral artery flow velocity patterns as measured by transcranial Doppler ultrasound (TCD) in eclampsia and to investigate the effect of the anticonvulsants magnesium sulphate (MgSO4) and phenytoin on cerebral circulation." | 5.08 | Randomised study assessing the effect of phenytoin and magnesium sulphate on maternal cerebral circulation in eclampsia using transcranial Doppler ultrasound. ( Gouws, E; Hoffmann, M; Moodley, J; Naidu, S; Payne, AJ, 1996) |
| "Our objective was to evaluate the patterns of malformations in children exposed in utero to phenytoin (DPH) and carbamazepine (CBZ) monotherapy, and to compare them prospectively with matched mother-child pairs exposed to nonteratogens, and to separate the effects of antiepileptic drugs (AEDs) from those of epilepsy by collecting groups of untreated epileptics and those treated with DPH and CBZ for conditions other than epilepsy." | 5.08 | Findings in children exposed in utero to phenytoin and carbamazepine monotherapy: independent effects of epilepsy and medications. ( Chitayat, D; Farkas, LD; Koren, G; Nulman, I; Scolnik, D, 1997) |
| "The purpose of this study was to determine whether magnesium sulfate given for prevention of eclampsia affected labor outcomes compared with phenytoin, which is not known to impede uterine activity when given in anticonvulsant doses." | 5.08 | Does magnesium sulfate given for prevention of eclampsia affect the outcome of labor? ( Alexander, JM; Leveno, KJ; Lucas, MJ; McIntire, DD, 1998) |
| "Twenty-two patients with eclampsia were randomly allocated to receive either intravenous phenytoin sodium or intravenous magnesium sulphate." | 5.06 | Phenytoin sodium and magnesium sulphate in the management of eclampsia. ( Dommisse, J, 1990) |
| "This article reviews the evidence regarding the use of phenytoin in adult and paediatric patients experiencing seizures in the ED in Australasia, including relevant pharmacokinetics, dosage, therapeutic drug monitoring and methods of administration." | 4.86 | Review article: phenytoin use and efficacy in the ED. ( Gallop, K, 2010) |
| "The objective of this review was to assess the effects of magnesium sulphate compared with phenytoin when used for the care of women with eclampsia." | 4.86 | Magnesium sulphate versus phenytoin for eclampsia. ( Chou, D; Duley, L; Henderson-Smart, DJ, 2010) |
| "The objective of this review was to assess the effects of magnesium sulphate compared with phenytoin when used for the care of women with eclampsia." | 4.82 | Magnesium sulphate versus phenytoin for eclampsia. ( Duley, L; Henderson-Smart, D, 2003) |
| "The objective of this review was to assess the effects of magnesium sulphate compared with phenytoin when used for the care of women with eclampsia." | 4.80 | Magnesium sulphate versus phenytoin for eclampsia. ( Duley, L; Henderson-Smart, D, 2000) |
| "The developmental neurotoxicity of phenytoin, isotretinoin, and methamphetamine has been reviewed to illustrate effects from both therapeutic and illicit drugs to which people are exposed and which either induce or show the potential for inducing learning disabilities following in utero exposure." | 4.79 | Developmental neurotoxicity induced by therapeutic and illicit drugs. ( Vorhees, CV, 1994) |
| "We evaluated the causality of the association between intrauterine exposure to phenytoin and postnatal neuroblastoma using an in vitro lymphocyte toxicity assay for phenytoin-induced reactions in an unusual sibship." | 4.77 | Neuroblastoma after prenatal exposure to phenytoin: cause and effect? ( Demitrakoudis, D; Koren, G; Rieder, M; Shandling, B; Shear, NH; Sonely, M; Spielberg, SP; Weksberg, R, 1989) |
| "Usage during pregnancy of the antiseizure medication (ASM), phenobarbital (PB), carbamazepine (CBZ), and phenytoin (PHT), has been associated with adverse pregnancy outcomes." | 4.12 | Neuropsychological effects in children exposed to anticonvulsant monotherapy during gestation: Phenobarbital, carbamazepine, and phenytoin. ( Adams, J; Carlson, JM; Dhillon, R; Holmes, LB; Janulewicz, PA; Macklin, EA; Phillips, C; Schomer, DL; Tosches, WA, 2022) |
| " In the early morning of day 3, while midazolam was administered up to the maximum dose, the infant developed status epilepticus, and the anticonvulsant drug was changed to phenytoin." | 4.02 | Rapid infusion of excessive phenytoin: A newborn autopsy case. ( Ichioka, H; Idota, N; Ikegaya, H; Kondou, H; Shintani-Ishida, K, 2021) |
| "This study was carried out to determine changes over time in use of folic acid, anti-epileptic drugs (AED), seizures during pregnancy and malformation rate over two decades in women with epilepsy enrolled in the Kerala registry of Epilepsy and Pregnancy (KREP)." | 3.96 | Anti-epileptic drug and folic acid usage during pregnancy, seizure and malformation outcomes: Changes over two decades in the Kerala Registry of Epilepsy and Pregnancy. ( A S, R; Baishya, J; Jose, M; Keni, RR; Sankara Sarma, P; Thomas, SV, 2020) |
| "The "anticonvulsant face," with a short nose, broad nasal bridge, epicanthal folds, and wide mouth, was described in the 1970s in children who had been exposed during pregnancy to the anticonvulsant drugs phenytoin and phenobarbital." | 3.80 | Laser light scan analysis of the "anticonvulsant face". ( Deutsch, CK; Holmes, LB; Orup, HI, 2014) |
| " We studied 174 pregnancies in 155 women who used phenytoin throughout their pregnancy, gave birth to a live child and had available stored blood specimens suitable for DNA extraction." | 3.76 | Maternal EPHX1 polymorphisms and risk of phenytoin-induced congenital malformations. ( Azzato, EM; Caporaso, NE; Chanock, SJ; Chen, RA; Klebanoff, MA; Wacholder, S, 2010) |
| "Between 1999 and 2004, we enrolled pregnant women with epilepsy who were taking a single antiepileptic agent (carbamazepine, lamotrigine, phenytoin, or valproate) in a prospective, observational, multicenter study in the United States and the United Kingdom." | 3.75 | Cognitive function at 3 years of age after fetal exposure to antiepileptic drugs. ( Baker, GA; Browning, N; Clayton-Smith, J; Cohen, M; Combs-Cantrell, DT; Kalayjian, LA; Kanner, A; Liporace, JD; Loring, DW; Meador, KJ; Pennell, PB; Privitera, M, 2009) |
| "(1) Numerous follow-up studies of pregnancies in women with epilepsy show that valproic acid is more teratogenic than other antiepileptics." | 3.75 | Valproic acid: long-term effects on children exposed in utero. ( , 2009) |
| " We studied congenital abnormalities following exposure to phenytoin, phenobarbital, and diazepam in early pregnancy, i." | 3.74 | Use of phenytoin, phenobarbital, or diazepam during pregnancy and risk of congenital abnormalities: a case-time-control study. ( Christensen, J; Czeizel, AE; Horvath-Puhó, E; Kjaer, D; Olsen, J; Sørensen, HT; Vestergaard, M, 2007) |
| "An increased risk for isolated CL/P was found in cases born to mothers treated with amoxicillin, phenytoin, oxprenolol, and thiethylperazine during the second and third month of pregnancy, i." | 3.74 | Drug treatment during pregnancy and isolated orofacial clefts in hungary. ( Czeizel, AE; Métneki, J; Puhó, EH; Szunyogh, M, 2007) |
| "Children exposed during pregnancy to the anticonvulsant drugs phenytoin, phenobarbital, and carbamazepine as monotherapy and polytherapy have an increased frequency of midface and digit hypoplasia." | 3.73 | The correlation of deficits in IQ with midface and digit hypoplasia in children exposed in utero to anticonvulsant drugs. ( Coull, BA; Dorfman, J; Holmes, LB; Rosenberger, PB, 2005) |
| "Our previous genome-wide Quantitative Trait Locus (QTL) mapping study using mouse A/J by C57BL/6J recombinant inbred (RI) lines suggested several chromosomal regions contain genes influencing susceptibility to phenytoin (PT)-induced cleft lip with or without cleft palate [CL(P)] and 6-aminonicotinamide (6-AN)-induced isolated cleft palate (CP)." | 3.73 | Correlation of susceptibility to 6-aminonicotinamide and hydrocortisone-induced cleft palate. ( Diehl, SR; Erickson, RP; Karolyi, IJ, 2005) |
| "3 in a fetus exposed to phenytoin during pregnancy." | 3.73 | A fragile site at 10q23 (FRA10A) in a phenytoin-exposed fetus: a case report and review of the literature. ( Désilets, V; Duncan, AM; Morel, CF, 2005) |
| " Chronic hypoxia was induced by administration of the anticonvulsant phenytoin (PHT) during pregnancy." | 3.73 | Phenytoin induced oxidative stress in pre- and postnatal rat development - effect of vitamin E on selective biochemical variables. ( Dubovický, M; Mach, M; Navarová, J; Ujházy, E, 2005) |
| " The AEDs received by the mothers with epilepsy were Phenytoin, Carbamazepine, and Sodium valproate." | 3.73 | Physical growth and psychomotor development of infants exposed to antiepileptic drugs in utero. ( Arulmozhi, T; Dhanaraj, M; Rangaraj, R; Vengatesan, A, 2006) |
| "There are many reports that the teratogenic effects of phenytoin, especially cleft palate can be decreased by stimulation of maternal immune system." | 3.73 | A comparison study of effects of Echinacea extract and levamisole on phenytoin-induced cleft palate in mice. ( Arzi, A; Khaksary Mahabady, M; Najafzadeh, H; Papahn, AA; Ranjbar, R, 2006) |
| "An infant who was exposed to phenytoin as monotherapy throughout pregnancy was born with the following abnormalities: midface hypoplasia, digit hypoplasia with syndactyly in the hands and feet, meningomyelocele, talipes equinovarus, and a long skin pedicle on the back." | 3.72 | Multiple congenital anomalies associated with in utero exposure of phenytoin: possible hypoxic ischemic mechanism? ( Holmes, LB; Huang, T; Lyon, HM, 2003) |
| "The present pre- and postnatal study was carried out to investigate the effect of melatonin (MEL), a potent antioxidant, on biochemical variables in the in vivo model of intrauterine hypoxia in rats." | 3.72 | Effect of melatonin on biochemical variables induced by phenytoin in organs of mothers, foetuses and offsprings of rats. ( Dubovický, M; Mach, M; Navarová, J; Ujházy, E, 2004) |
| "The aim of the present study was to test the hypothesis that the natural antioxidant melatonin (MEL) and the synthetic antioxidant stobadine (STO) could reduce the incidence of maternal and embryofoetal toxicity in rats due to intrauterine hypoxia." | 3.72 | Effect of melatonin and stobadine on maternal and embryofoetal toxicity in rats due to intrauterine hypoxia induced by phenytoin administration. ( Brucknerová, I; Dubovický, M; Juránek, I; Mach, M; Navarová, J; Soltés, L; Ujházy, E; Zeman, M, 2004) |
| " The boy was exposed to phenytoin, in combination with carbamazepine, during pregnancy." | 3.71 | Chondrodysplasia punctata (CDP) with features of the tibia-metacarpal type and maternal phenytoin treatment during pregnancy. ( Annerén, G; Brandberg, G; Larsson, M; Lönnerholm, T; Wester, U, 2002) |
| "There is evidence that drug-induced embryonic arrhythmia initiates phenytoin (PHT) teratogenicity." | 3.71 | Embryonic arrhythmia by inhibition of HERG channels: a common hypoxia-related teratogenic mechanism for antiepileptic drugs? ( Azarbayjani, F; Danielsson, BR, 2002) |
| " In an animal model of phenytoin-induced cleft palate, we report that Hoxa-2 mRNA and protein expression were significantly decreased, implicating a possible functional role of the Hoxa-2 gene in the development of phenytoin-induced cleft palate." | 3.70 | Temporal and spatial expression of Hoxa-2 during murine palatogenesis. ( Hao, Z; Leung, V; Nazarali, A; Puthucode, R; Wolf, L; Yeung, J, 2000) |
| "To compare pregnancy outcome prospectively after phenytoin and carbamazepine monotherapy with outcome in matched mother-child pairs exposed to nonteratogens to evaluate the relative fetal safety of these drugs." | 3.69 | Neurodevelopment of children exposed in utero to phenytoin and carbamazepine monotherapy. ( Ashby, P; Czuchta, D; Einarson, T; Gardner, HA; Gladstone, D; Gladstone, R; Nulman, I; Rovet, J; Scolnik, D; Weksberg, R, 1994) |
| "Urinary excretions of carbamazepine, carbamazepine-10,11-epoxide, carbamazepine-10,11-trans-diol, 9-hydroxyacridan and 2- and 3-hydroxycarbamazepine were measured at various stages of pregnancy, and in the post-natal period, in ten epileptic women, six of whom took no other enzyme-inducing anticonvulsant and four of whom took such co-medication." | 3.69 | Metabolism of carbamazepine and co-administered anticonvulsants during pregnancy. ( Bernus, I; Dickinson, RG; Eadie, MJ; Hooper, WD, 1995) |
| "The expression and ligand binding characteristics of sigma-receptors in human placental syncytiotrophoblast and choriocarcinoma cells were investigated using haloperidol as a ligand." | 3.69 | Cocaine-sensitive sigma-receptor and its interaction with steroid hormones in the human placental syncytiotrophoblast and in choriocarcinoma cells. ( Ganapathy, V; Leibach, FH; Mahesh, VB; Ramamoorthy, JD; Ramamoorthy, S, 1995) |
| "Phenytoin serum concentrations were evaluated in 88 epileptic women at different stages of pregnancy and 40 women during postnatal periods." | 3.69 | Phenytoin serum concentration monitoring during pregnancy and puerperium in Mexican epileptic women. ( Amancio-Chassin, O; Belmont-Gómez, A; Estrada-Altamirano, A; Hernández-Serrano, M; Herrerías-Cunedo, T; Rodríguez-Palomares, C, 1995) |
| "New Zealand White rabbits were treated orally with 0 (controls), 50, 100, or 150 mg/kg phenytoin on days 14-16 of pregnancy." | 3.69 | Phenytoin causes phalangeal hypoplasia in the rabbit fetus at clinically relevant free plasma concentrations. ( Danielson, K; Danielsson, BR; Tomson, T, 1995) |
| "The aim of this study was to investigate if phenytoin has the capacity to induce embryonic hypoxia mediated via adverse effects on the embryonic heart." | 3.69 | Initiation of phenytoin teratogenesis: pharmacologically induced embryonic bradycardia and arrhythmia resulting in hypoxia and possible free radical damage at reoxygenation. ( Azarbayjani, F; Danielsson, BR; Sköld, AC; Webster, WS, 1997) |
| "To determine plasma phenytoin levels and seizure outcome in women given phenytoin for seizure prophylaxis in severe pre-eclampsia and eclampsia." | 3.68 | Phenytoin prophylaxis in severe pre-eclampsia and eclampsia. ( Campbell, M; de Swiet, M; Redfern, N; Robson, SC; Rodeck, C; Seviour, J; Walkinshaw, S, 1993) |
| "To investigate the efficacy of phenytoin in relation to total and free serum levels in patients with severe pre-eclampsia and eclampsia." | 3.68 | The efficacy of phenytoin in relation to serum levels in severe pre-eclampsia and eclampsia. ( Botha, J; McFadyen, L; Moodley, J; Naidu, S, 1992) |
| "The steady-state 72 h urinary excretion of various phenytoin metabolites has been measured in 10 epileptic women, whose plasma phenytoin concentrations relative to the phenytoin dose fell during pregnancy and rose again post-partum." | 3.68 | Phenytoin metabolism during pregnancy. ( Dickinson, RG; Eadie, MJ; Hooper, WD; Lander, CM; McKinnon, GE, 1992) |
| "There is evidence that vitamin K-deficiency during human pregnancy can be caused by the therapeutic use of warfarin or phenytoin." | 3.68 | Binder's syndrome due to prenatal vitamin K deficiency: a theory of pathogenesis. ( Halliday, JL; Howe, AM; Lipson, AH; Sheffield, LJ; Webster, WS, 1992) |
| "Mice of the A/J and C57BL/6J (C57) strains were dosed with phenytoin (PHT) every 48 hr throughout pregnancy by gastric intubation to test the hypothesis that maternal plasma PHT concentration may be the significant factor in determining PHT reproductive and developmental toxicity." | 3.68 | Phenytoin teratogenicity and midgestational pharmacokinetics in mice. ( Laborde, JB; Roberts, LG; Slikker, W, 1991) |
| "The effects of antiepileptic drugs (AED) on infants during pregnancy and delivery were studied in a total of 82 epileptic mothers on various monotherapies; 29 cases receiving valproic acid (VPA), 20 receiving phenytoin (PHT), 18 on carbamazepine (CBZ) and 15 on phenobarbital (PB)." | 3.68 | [Effects of antiepileptic drugs on delivery and early childhood--comparison among mono-therapies of valproic acid, phenytoin, carbamazepine and phenobarbital]. ( Ishikawa, S; Izumi, M; Okada, H; Takeda, A; Tanaka, H, 1991) |
| "An infant with dysmorphic features was born to an epileptic mother who had taken phenytoin and sodium valproate throughout pregnancy." | 3.68 | Neocerebellar hypoplasia in a neonate following intra-uterine exposure to anticonvulsants. ( Hope, PL; Lindenbaum, RH; Squier, W, 1990) |
| " Seventy-six children of the study group had been exposed to phenytoin in the first 20 weeks of pregnancy, 21 had been exposed to other anti-epileptic drugs excluding phenytoin, and 14 had not been exposed." | 3.68 | Distal phalangeal hypoplasia in children with prenatal phenytoin exposure: results of a controlled anthropometric study. ( Gaily, E, 1990) |
| " Fifty-two children had been exposed to phenytoin monotherapy, 19 to carbamazepine monotherapy, 27 to drug combinations including barbiturates, 29 to other drug combinations, and 17 children had not been exposed to antiepileptic drugs (AEDs) during pregnancy." | 3.68 | Head circumference in children of epileptic mothers: contributions of drug exposure and genetic background. ( Bardy, AH; Gaily, EK; Granström, ML; Hiilesmaa, VK, 1990) |
| "Phenytoin sodium was administered intravenously as a single 900 mg dose in 33 consecutive women with eclampsia immediately on admission." | 3.68 | Single high dose of intravenous phenytoin sodium for the treatment of eclampsia. ( Coyaji, KJ; Otiv, SR, 1990) |
| " The groups A and B were supplemented with a mixture of folic acid (FA) or with FA alone in the food fed during pregnancy." | 3.68 | [Effect of diphenylhydantoin sodium in causing deformity and that of folic acid preparations for its prevention]. ( Zhu, MX, 1990) |
| "Serum concentrations of the main vitamin D metabolites and of calcium, phosphate, and alkaline phosphatase were determined in each of the three trimesters of pregnancy and in simultaneously obtained maternal and cord blood at delivery in 22 epileptic women treated with diphenylhydantoin or carbamazepine alone or with a combination with one other drug." | 3.67 | Anticonvulsant drug therapy in human pregnancy: effects on serum concentrations of vitamin D metabolites in maternal and cord blood. ( Aarskog, D; Aksnes, L; Markestad, T; Strandjord, RE; Ulstein, M, 1984) |
| " We measured FT4 in a total of 325 serum samples from euthyroid patients; patients receiving replacement thyroxin; patients receiving estrogens or who were pregnant; hyperthyroid, hypothyroid, and non- thyroidally ill patients; and patients receiving salicylates, phenytoin, or heparin." | 3.67 | Estimation of free thyroxin with a new thyroxin analog and a porous-glass solid phase. ( Gilbert, SS; Shuler, SE; Witherspoon, LR, 1984) |
| "A female neonate, whose mother had been treated throughout pregnancy with valproic acid and phenytoin, showed evident signs of liver damage, confirmed by laboratory investigations and biopsy." | 3.67 | Congenital liver damage after treatment of mother with valproic acid and phenytoin? ( Felding, I; Rane, A, 1984) |
| "Five epileptic women needing to commence phenytoin therapy during pregnancy received a single intravenous and a single oral dose of phenytoin several days apart before starting regular intake of the drug." | 3.67 | Bioavailability and pharmacokinetics of phenytoin during pregnancy. ( Chalk, JB; de Wytt, C; Eadie, MJ; Lander, CM; Livingstone, I; Smith, MT; Symoniw, P, 1984) |
| "The concentrations of both total and free phenytoin in the plasma of epileptic women tend to decrease during pregnancy, suggestive of a pregnancy-associated increase in the metabolic clearance of the drug." | 3.67 | Effect of folic acid on the pharmacokinetics of acutely administered phenytoin in pregnant and nonpregnant rats. ( Chou, RC; Levy, G, 1984) |
| "The purposes of this investigation were to determine the effect of pregnancy on the susceptibility of female rats to experimentally induced seizures and on the relationship between serum phenytoin concentration and antiseizure activity." | 3.67 | Kinetics of drug action in disease states III: Effect of pregnancy on the relationship between phenytoin concentration and antiseizure activity in rats. ( Chou, RC; Levy, G, 1984) |
| "Chromosome studies were carried out on the peripheral blood of 26 epilepsy patients treated with phenobarbital and/or diphenylhydantoin, on ten healthy controls and on eight untreated epileptic controls." | 3.67 | Chromosomal studies of peripheral blood from epileptic patients treated with phenobarbital and/or diphenylhydantoin. ( Ambani, LM; Kulkarni, PS; Mondkar, VP; Sonawalla, AB, 1984) |
| "The toxic interaction of caffeine and phenytoin during pregnancy was investigated in mice of the ICR strain on E10 of gestation." | 3.67 | The toxicology of chemical interactions during pregnancy in the mouse: caffeine and phenytoin. ( Kwasigroch, TE; Poche, PD; Skalko, RG, 1984) |
| "Both phenytoin (PHT) and glucocorticoid (GC) have been reported to be an effective teratogen for the production of cleft palate." | 3.67 | The relation between phenytoin-receptor and glucocorticoid in the induction of cleft palate with phenytoin in mice. ( Inayoshi, K; Kurisu, K; Nagata, K; Ohsaki, Y, 1989) |
| "The estimation of Michaelis-Menten pharmacokinetic parameters in patients with epilepsy receiving phenytoin continues to be a vexing problem." | 3.67 | Determination of enzyme or binding constants using generalized linear models, with particular reference to Michaelis-Menten models. ( Friel, P; Guo, SW; Leurgans, S; van Belle, G; Yerby, M, 1989) |
| "Intravenous phenytoin sodium was given as a high-dose infusion (10 X 8-18 mg/kg) for anticonvulsive prophylaxis to 2 eclamptic patients and to 24 patients with moderate to severe pre-eclampsia." | 3.67 | Phenytoin infusion in severe pre-eclampsia. ( Anderton, JM; D'Souza, SW; Donnai, P; Mawer, GE; Patrick, J; Richardson, T; Slater, RM; Smith, WD; Wilcox, FL, 1987) |
| "The development of rats was studied for 3 postnatal weeks after prenatal medication with diazepam (10 mg/kg/day), phenytoin (50 mg/kg/day), or tofizopam (50 mg/kg twice daily) given by gastric intubation from day 7 to 21 of pregnancy." | 3.67 | Effects of diazepam, tofizopam or phenytoin during foetal development on subsequent behaviour and benzodiazepine receptor characteristics in rats. ( Laitinen, K; MacDonald, E; Saano, V, 1986) |
| "A 26-year-old woman, treated with phenytoin for 10 years because of epilepsy, had Norplant subdermal implants inserted after a legal abortion." | 3.67 | Enhanced metabolism of levonorgestrel during phenytoin treatment in a woman with Norplant implants. ( Odlind, V; Olsson, SE, 1986) |
| " Of the study group, 106 children had been exposed to antiepileptic drugs (82 to phenytoin) during pregnancy; 44 (36%) mothers had had generalized convulsions during pregnancy." | 3.67 | Minor anomalies in offspring of epileptic mothers. ( Bardy, A; Gaily, E; Granström, ML; Hiilesmaa, V, 1988) |
| " However, mothers who had one affected child appeared to be at much higher risk for having subsequent affected children (9 of 10) if phenytoin use was continued through future pregnancies than were mothers whose first-born child was unaffected despite being exposed to phenytoin during the pregnancy (5 of 52 among all families, or 1 of 48 when only children exposed throughout the entire pregnancy were included)." | 3.67 | Family studies in fetal phenytoin exposure. ( Heide, F; Hill, LR; Hodge, SE; Van Dyke, DC, 1988) |
| "We recently encountered a male newborn with ambiguous genitalia who had been exposed to the anticonvulsant phenytoin in utero." | 3.67 | The effect of phenytoin on testosterone metabolism in vitro. ( Martin, HF; Orson, J; Owens-Stively, JA, 1985) |
| " It has been shown the prenatal phenytoin administration (100 mg kg-1 orally, days 7-19 of pregnancy) increased serum tryptophan and brain tryptophan, 5-HT and 5-HIAA of rat offspring at 3 days of age but not at 4, 15 or 21 days of age." | 3.66 | Effect of prenatal phenytoin administration on brain tryptophan metabolism of rat offspring during the preweaning period. ( Elmazar, MM; Sullivan, FM, 1980) |
| "Phenytoin administered to pregnant mice during the critical embryonic period of palatal differentiation produced 50% cleft palates in the Ajax (A/J) strain compared to 1." | 3.66 | Susceptibility of mice to phenytoin-induced cleft palate correlated with inhibition of fetal palatal RNA and protein synthesis (41255). ( Goldman, AS; Sonawane, BR, 1981) |
| "The authors studied antipyrine disposition before and after delivery in 4 epileptic women whose anticonvulsant plasma level per dosage ratio was lowered during pregnancy, and compared the results to those found in nonpregnant women undergoing antiepileptic treatment (N = 6) and healthy women (N = 6)." | 3.66 | Antipyrine disposition in relation to lowered anticonvulsant plasma level during pregnancy. ( Chiba, K; Ishizaki, T; Nakazawa, Y; Tabuchi, T; Wagatsuma, T, 1982) |
| "Pregnant female mice of various congenic strains were injected on days 11 through 14 of gestation with phenytoin, and the fetuses were examined for the occurrence of cleft palate." | 3.66 | Susceptibility to phenytoin-induced cleft palate in mice is influenced by genes linked to H-2 and H-3. ( Baker, MK; Gasser, DL; Goldman, AS, 1983) |
| "1 The effect of pregnancy on the binding of phenytoin and phenobarbitone to serum proteins was studied in normal women and in drug treated epileptic women." | 3.66 | Serum protein binding and free concentration of phenytoin and phenobarbitone in pregnancy. ( Chen, SS; Lee, JN; Perucca, E; Richens, A, 1982) |
| " Administering phenytoin in the drinking water of females homozygous for the quaking allele reduced the frequency of tonic-clonic seizures typical for this mutant from a background rate of 2." | 3.66 | Mouse fetal hydantoin syndrome: effects of maternal seizures. ( Chernoff, GF; Finnell, RH, 1982) |
| "Chronic treatment of female rats with buformin (k mg/day per rat) is shown to decrease the body weight, to increase the average life span by 9% and to reduce the incidence of spontaneous tumors." | 3.66 | [Effect of buformin and diphenylhydantoin on the life span, estrous function and spontaneous tumor incidence in rats]. ( Anisimov, VN, 1980) |
| "Adult pregnant Wistar rats were treated with phenytoin (100 Mg/kg) orally from day 7 to 19 of pregnancy, and a control group was pair-fed during the whole treatment period." | 3.66 | Effect of prenatal phenytoin administration on postnatal development of the rat: a behavioral teratology study. ( Elmazar, MM; Sullivan, FM, 1981) |
| "The serum protein binding of three weakly acidic drugs (salicylic acid, sulfisoxazole, and phenytoin), one week base (diazepam), and one steroid (dexamethasone) was determined in pregnant women at seven time periods during pregnancy and at two periods post partum, as well as in a group of nonpregnant women of childbearing age." | 3.66 | Serum protein binding of drugs during and after pregnancy in humans. ( Dean, M; Levy, G; Patterson, RJ; Stock, B, 1980) |
| "Blood levels of phenytoin, total thyroxine, and free thyroxine were determined in 10 epileptic women during and following pregnancy." | 3.66 | Epilepsy and pregnancy. Serum thyroxine levels during phenytoin therapy. ( Ramsay, RE; Spellacy, WN; Strauss, RG; Wilder, BJ; Willmore, LJ, 1979) |
| " The treatment of status epilepticus with intravenous phenytoin is effective." | 3.66 | Epilepsy and pregnancy. ( Bruni, J; Willmore, LJ, 1979) |
| "High incidences of cleft lip and palate (CLP) produced by maternal intraperitoneal administration of 75 mg/kg phenytoin on gestational day 10 to A/J mice are associated with a severe size reduction in the lateral nasal process." | 3.66 | Phenytoin (dilantin)-induced cleft lip and palate in A/J mice: a scanning and transmission electron microscopic study. ( Ambrose, LJ; Dorgan, D; Johnston, MC; Sulik, KK, 1979) |
| "1 The kinetics of phenytoin and its main metabolites, unconjugated and conjugated 4-hydroxy-phenytoin were studied in newborn infants of epileptic mothers that were treated with phenytoin during the pregnancy." | 3.66 | Kinetics of placentally transferred phenytoin and its p-hydroxylated metabolites in newborn infants. ( Höjer, B; Hoppel, C; Rane, A, 1979) |
| "Birth defects associated with phenytoin and phenobarbital taken during pregnancy include craniofacial and limb deformities." | 3.66 | Fetal hydantoin syndrome in triplets. A unique experiment of nature. ( Bustamante, SA; Stumpff, LC, 1978) |
| ", raise the possibility that fetal damage previously attributed to phenytoin and other anticonvulsant drugs, principally phenobarbitone, may be due to epilepsy itself." | 3.65 | Anticonvulsants and parental epilepsy in the development of birth defects. ( Hartz, SC; Heinonen, OP; Mitchell, AA; Monson, RR; Rosenberg, L; Shapiro, S; Siskind, V; Slone, D, 1976) |
| "Plasma anticonvulsant levels were followed during pregnancy in 11 epileptic women taking phenytoin and/or phenobarbital or a drug metabolized in the body to phenobarbital." | 3.65 | Plasma anticonvulsant concentrations during pregnancy. ( Eadie, MJ; Edwards, VE; Lander, CM; Tyrer, JH, 1977) |
| "Malignant mesenchymoma developed in an 18-year-old patient with phenytoin-associated cleft lip and palate." | 3.65 | Malignant mesenchymoma and birth defects. Prenatal exposure to phenytoin. ( Blattner, WA; Fraumeni, JF; Henson, DE; Young, RC, 1977) |
| " In the Hungarian Congenital Malformation Register use of the anticonvulsants diazepam and phenobarbiturates during pregnancy was determined in infants delivered with cleft lip with or without cleft palate, posterior cleft palate and, as a control, anencephaly and spina bifida." | 3.65 | A teratological evaluation of anticonvulsant drugs. ( Czeizel, E; Lakos, P, 1977) |
| "A second case of severe limb malformations was observed following maternal use of haloperidol early in the first trimester of pregnancy." | 3.65 | Limb malformations following maternal use of haloperidol. ( Heggeness, L; McCullar, FW, 1975) |
| "This editorial was prompted by the published association of maternal diethylstilbestrol (DES) ingestion during pregnancy and subsequent development of vaginal adenocarcinoma among female offspring, and explores various factors involved in transplacental chemical carcinogenesis in humans." | 3.65 | Transplacental chemical carcinogenesis in man. ( Miller, RW, 1971) |
| "Levetiracetam has been widely used as a treatment option for different types of epilepsy in both adults and children." | 2.72 | Population Pharmacokinetics of Levetiracetam: A Systematic Review. ( Jiao, Z; Li, ZR; Wang, CY; Zhu, X, 2021) |
| "Seizure activity in patients with acute liver failure (ALF) may increase cerebral oxygen requirements and worsen cerebral edema." | 2.71 | Prophylactic phenytoin does not improve cerebral edema or survival in acute liver failure--a controlled clinical trial. ( Acharya, SK; Batra, Y; Bhatia, V, 2004) |
| "Fluconazole (FCZ) is an antifungal bis-triazole with potent inhibitory effect on the principal CYP-dependent metabolic pathway of PHT." | 2.69 | Teratological interaction between the bis-triazole antifungal agent fluconazole and the anticonvulsant drug phenytoin. ( Bellati, U; Di Ilio, C; Giampietro, F; Iammarrone, E; Lamonaca, D; Tiboni, GM, 1999) |
| "Of 467 patients with preeclampsia or superimposed preeclampsia managed without seizure prophylaxis, 18 had seizure activity, 3." | 2.68 | The feasibility of a control population for a randomized control trial of seizure prophylaxis in the hypertensive disorders of pregnancy. ( Burrows, EA; Burrows, RF, 1995) |
| "Eclampsia, the occurrence of a seizure in association with pre-eclampsia, remains an important cause of maternal mortality." | 2.68 | Which anticonvulsant for women with eclampsia? Evidence from the Collaborative Eclampsia Trial. ( , 1995) |
| "Pregnancy was thus associated with increased microsomal oxidations of phenytoin and carbamazepine, without proportionate increases in the subsequent hydrolysis of carbamazepine-10,11-epoxide and in the O-glucuronidations of the earlier stage metabolites." | 2.68 | Effects of pregnancy on various pathways of human antiepileptic drug metabolism. ( Bernus, I; Dickinson, RG; Eadie, MJ; Hooper, WD, 1997) |
| "The objective of this study was to assess the feasibility of giving phenytoin to a group of mild preeclamptic women in a universal dosing scheme comparable to that typical of magnesium sulfate administration." | 2.67 | A simplified phenytoin regimen for preeclampsia. ( Cunningham, FG; DePalma, RT; Leveno, KJ; Lucas, MJ; Person, D; Peters, MT, 1994) |
| "Phenytoin is a well-tolerated alternative to magnesium sulfate for seizure prophylaxis in the patient with mild pregnancy-induced hypertension." | 2.67 | Magnesium sulfate versus phenytoin for seizure prophylaxis in pregnancy-induced hypertension. ( Adams, HR; Appleton, MP; Gold, WR; Knight, AB; Kuehl, TJ; Raebel, MA, 1991) |
| "Phenytoin has been widely prescribed alone; our results indicate that sodium valproate may also be used as a single drug in the treatment of several types of epilepsy." | 2.65 | Comparison of sodium valproate and phenytoin as single drug treatment in epilepsy. ( Johnson, RH; Lambie, DG; Melville, ID; Nanda, RN; Shakir, RA, 1981) |
| "Epilepsy affects fetal brain development during gestation in pregnant rats, therefore anti-epileptic therapy should be continued during pregnancy." | 2.53 | Effects of phenytoin and lamotrigine treatment on serum BDNF levels in offsprings of epileptic rats. ( Doğan, Z; Kamışlı, Ö; Soysal, H, 2016) |
| "Seizures and intracranial hemorrhage are possible medical diseases that any obstetrician may encounter." | 2.49 | Seizures and intracranial hemorrhage. ( Alexander, JM; Wilson, KL, 2013) |
| "Phenobarbital was associated with a higher rate of drug withdrawal although there was no evidence to suggest that phenobarbital caused more adverse events compared to carbamazepine, valproic acid or phenytoin." | 2.47 | Side effects of phenobarbital in epilepsy: a systematic review. ( Li, YP; Zeng, LN; Zhang, LL, 2011) |
| " Instead, single dosing on specific days is proposed to be a better way to characterize the teratogenic potential of Ikr blocking drugs." | 2.44 | Embryonic cardiac arrhythmia and generation of reactive oxygen species: common teratogenic mechanism for IKr blocking drugs. ( Danielsson, BR; Danielsson, C; Nilsson, MF, 2007) |
| "Eclampsia is the third commonest cause of maternal mortality after haemorrhage and infection." | 2.41 | Magnesium sulphate for eclampsia: putting the evidence into clinical practice. ( Manyemba, J, 2000) |
| " Rates of metabolism in children may be much faster than in nonelderly adults, requiring dosing adjustments to ensure enough medication is used to control seizures." | 2.41 | Treatment of epilepsy in 3 specialized populations. ( Leppik, IE, 2001) |
| "The characteristics and treatment of preeclampsia and eclampsia are reviewed." | 2.38 | Treatment of preeclampsia and eclampsia. ( McCombs, J, 1992) |
| "As stated in an earlier review, "in treating preeclampsia, magnesium sulfate therapy may have a role and may moderate factors leading to eclampsia." | 2.38 | Prophylaxis of eclamptic seizures: current controversies. ( Friedman, SA; Kaplan, PW; Repke, JT, 1992) |
| "Eclamptic seizures are clinically and electroencephalographically indistinguishable from generalized tonic-clonic seizures." | 2.38 | A continuing controversy: magnesium sulfate in the treatment of eclamptic seizures. ( Fisher, RS; Hanley, DF; Kaplan, PW; Lesser, RP; Repke, JT, 1990) |
| "The pathogenesis of eclamptic convulsions is unknown." | 2.38 | Magnesium sulfate is the ideal anticonvulsant in preeclampsia-eclampsia. ( Sibai, BM, 1990) |
| "Valproic acid is an anticonvulsant that has been associated with open neural tube defects." | 2.38 | Valproic acid prenatal exposure. Association with lipomyelomeningocele. ( Carter, BS; Stewart, JM, 1989) |
| " Special consideration, however, must be given with regard to drug selection and dosage in order to avoid adverse effects on the mother and fetus." | 2.36 | Antiarrhythmic drug therapy during pregnancy. ( Elkayam, U; Frishman, W; Rotmensch, HH, 1983) |
| "Anticonvulsant therapy was among the first areas to benefit from clinical pharmacokinetic studies." | 2.35 | Clinical pharmacokinetics of anticonvulsants. ( Dam, M; Hvidberg, EF, 1976) |
| "Phenytoin is a known human teratogen with unknown etiology." | 1.62 | The effect of phenytoin on embryonic heart rate in Vivo. ( Ababneh, D; Abela, D; Farrell, E; Hegedus, E; Howe, AM; Ritchie, HE, 2021) |
| "Evidence for the comparative teratogenic risk of antiepileptic drugs is insufficient, particularly in relation to the dosage used." | 1.48 | Comparative risk of major congenital malformations with eight different antiepileptic drugs: a prospective cohort study of the EURAP registry. ( Battino, D; Bonizzoni, E; Craig, J; Lindhout, D; Perucca, E; Sabers, A; Thomas, SV; Tomson, T; Vajda, F, 2018) |
| "The seizures were confirmed using amplitude-integrated electroencephalography, and other possible causes of neonatal seizures were excluded." | 1.40 | Myoclonic seizures in a preterm baby: is this a presentation of venlafaxine withdrawal? ( Ansary, A; Ibhanesebhor, S; Manjunatha, C, 2014) |
| "Despite the widespread use of diphenylhydantoin (DPH), there is a lack of reliable information on the teratogenic effects, correlation with maternal and developmental toxicity, and dose-response relationship of DPH." | 1.38 | Dose-response effects of diphenylhydantoin on pregnant dams and embryo-fetal development in rats. ( Baek, HS; Kim, JC; Kim, SH; Lee, IC; Lim, JH; Moon, C; Park, SC; Shin, DH, 2012) |
| "Phenytoin was embryopathic in all strains without altering catalase activity but less so in the WT embryos for the aCat and hCat strains, which exhibited about half the catalase activity of CD-1 embryos." | 1.37 | Embryoprotective role of endogenous catalase in acatalasemic and human catalase-expressing mouse embryos exposed in culture to developmental and phenytoin-enhanced oxidative stress. ( Abramov, JP; Wells, PG, 2011) |
| "Infantile spasms are the signature seizures of West syndrome." | 1.37 | Carisbamate acutely suppresses spasms in a rat model of symptomatic infantile spasms. ( Galanopoulou, AS; Moshé, SL; Ono, T, 2011) |
| "Phenytoin (PHT) is a risk factor of cleft palate formation; however, the molecular mechanisms by which phenytoin exerts its teratogenic effects resulting in cleft palate remain unknown." | 1.36 | Effects of phenytoin on Satb2 and Hoxa2 gene expressions in mouse embryonic craniofacial tissue. ( Mao, XY; Tang, SJ, 2010) |
| "A number of drugs induced arrhythmias and these appeared to be related to either sodium channel blockade, which resulted in a double atrial beat for each ventricular beat, or I(Kr)/hERG blockade, which caused irregular atrial and ventricular beats." | 1.36 | The effect of drugs with ion channel-blocking activity on the early embryonic rat heart. ( Ababneh, D; Abela, D; Carlsson, K; Gavin, C; Khan, MK; Nilsson, MF; Ritchie, H; Webster, WS, 2010) |
| "Epilepsy has been associated with poor obstetric outcomes that could be the result of the epilepsy itself or a direct effect of anti-epileptic medication on placentation." | 1.35 | Phenytoin but not valproate directly affected in vitro trophoblast differentiation. ( Anin, S; Bates, MD; Chadwick, D; Neilson, JP; Quenby, SM; Vince, GS, 2008) |
| "Cranial MRI revealed a right frontal cavernous hemangioma." | 1.35 | Refractory status epilepticus during pregnancy secondary to cavernous angioma. ( Aladdin, Y; Gross, DW, 2008) |
| "PHT dose-dependently increased the hypoxia staining (6- and 11-fold after maternal dosing of 100 and 150 mg/kg, respectively) during the period I(Kr) is expressed and functional (GD 10)." | 1.33 | Phenytoin teratogenicity: hypoxia marker and effects on embryonic heart rhythm suggest an hERG-related mechanism. ( Azarbayjani, F; Blomgren, B; Danielsson, BR; Danielsson, C; Johansson, A; Sköld, AC, 2005) |
| "Phenytoin is a human and animal teratogen." | 1.33 | Increased susceptibility to phenytoin teratogenicity: excessive generation of reactive oxygen species or impaired antioxidant defense? ( Azarbayjani, F; Borg, LA; Danielsson, BR, 2006) |
| "The aim of this study was to test the effect of supranutritional dosage of the natural antioxidant vitamin E (VitE) on phenytoin (PHT) induced developmental toxicity and possible long-term effects in rat offspring." | 1.33 | Vitamin E supplementation in phenytoin induced developmental toxicity in rats: postnatal study. ( Dubovický, M; Kovacovský, P; Mach, M; Navarová, J; Ujházy, E, 2006) |
| "Fluconazole (FCZ) is a potent inhibitor of the cytochrome P450 (CYP)-mediated metabolism of the anti-epileptic agent phenytoin (PHT), a well-known human and animal teratogen." | 1.32 | Additional investigation on the potentiation of phenytoin teratogenicity by fluconazole. ( Angelucci, S; Bellati, U; Di Ilio, C; Giampietro, F; Moio, P; Tiboni, GM, 2003) |
| "Phenytoin (PHT) is an antiepileptic drug known to have teratogenic effects." | 1.32 | Effect of prenatal phenytoin administration on the fine structure of rat myocardium and aorta. ( Dubovický, M; Guller, L; Mach, M; Okruhlicová, L; Sotníková, R; Tribulová, N; Ujházy, E, 2003) |
| " Pharmacokinetic data correlated well with pregnancy outcome data." | 1.31 | Pharmacokinetic data support pharmacologically induced embryonic dysrhythmia as explanation to Fetal Hydantoin Syndrome in rats. ( Azarbayjani, F; Danielsson, B; Ohman, I; Sköld, AC; Webster, W, 2000) |
| " Plasma concentration curves and pharmacokinetic parameters did not show remarkable differences between the dose groups, indicating that absorption is the limiting factor at the dose range used." | 1.31 | Comparison of in vitro and in vivo developmental toxicity and pharmacokinetics of phenytoin in the rat. ( Beekhuijzen, ME; Klaassen, R; Piersma, AH; Rompelberg, CJ; Verhoef, A, 2000) |
| " Embryonic heart rate was also recorded on individual days after dosing days 9-16." | 1.31 | Phenytoin-induced cleft palate: evidence for embryonic cardiac bradyarrhythmia due to inhibition of delayed rectifier K+ channels resulting in hypoxia-reoxygenation damage. ( Azarbayjani, F; Danielsson, BR, 2001) |
| "Cerebral palsy was not diagnosed in any infant of a hypertensive mother compared with five of the controls." | 1.30 | Maternal hypertension and neurodevelopmental outcome in very preterm infants. ( Burns, YR; Gray, PH; King, JF; Mohay, HA; O'Callaghan, MJ, 1998) |
| "05), and dose-response studies (10-50 KU/kg) at 8 h showed maximal respective 4-fold and 2-fold increases in maternal and embryonic activities with a 50 KU/kg dose (p < ." | 1.30 | Maternal administration of superoxide dismutase and catalase in phenytoin teratogenicity. ( Wells, PG; Winn, LM, 1999) |
| "Phenytoin-treated embryos within 4 hr also demonstrated maximal 8-OH-2'-dG formation, which was substantially greater than that of controls, with a maximal 3-fold increase over controls at 24 hr (p < 0." | 1.29 | Phenytoin-initiated DNA oxidation in murine embryo culture, and embryo protection by the antioxidative enzymes superoxide dismutase and catalase: evidence for reactive oxygen species-mediated DNA oxidation in the molecular mechanism of phenytoin teratogen ( Wells, PG; Winn, LM, 1995) |
| "Phenytoin was cooxidized by peroxidases in both maternal hepatic microsomes and embryonic S-9 to initiate oxidative damage to tissue lipids and proteins." | 1.29 | Potential molecular targets mediating chemical teratogenesis: in vitro peroxidase-catalyzed phenytoin metabolism and oxidative damage to proteins and lipids in murine maternal hepatic microsomes and embryonic 9000g supernatant. ( Liu, L; Wells, PG, 1995) |
| " Previous work had demonstrated that PHT treatment significantly increased endogenous maternal corticosterone concentrations for approximately 48 hr after dosing in A/J mice." | 1.28 | Embryotoxicity of phenytoin in adrenalectomized CD-1 mice. ( Branham, WS; Hansen, DK; Holson, RR; Sheehan, DM, 1992) |
| ") maternal serum concentrations of PHT, MPH, and ETH 1 hour after dosing on gestational day 18 were 16." | 1.28 | Comparison of the behavioral teratogenic potential of phenytoin, mephenytoin, ethotoin, and hydantoin in rats. ( Acuff-Smith, KD; Minck, DR; Vorhees, CV, 1991) |
| "Thanatophoric dwarfism is not as rare as once thought." | 1.28 | Thanatophoric dwarfism; drugs and antenatal diagnosis; a case report. ( Meehan, FP; Rafla, NM, 1991) |
| " Pharmacokinetic sampling in oral and i." | 1.28 | Developmental toxicity and pharmacokinetics of oral and intravenous phenytoin in the rat. ( Binkerd, PE; Hendrickx, AG; Rowland, JR, 1990) |
| "The developmental toxicity and pharmacokinetic fate of phenytoin in the pregnant rhesus macaque (Macaca mulatta) were examined." | 1.28 | Developmental toxicity and pharmacokinetics of phenytoin in the rhesus macaque: an interspecies comparison. ( Binkerd, PE; Hendrickx, AG; Hendrie, TA; Rowland, JR, 1990) |
| " Both p-HPPH and m-HPPH were much less developmentally toxic than DPH." | 1.28 | Use of Frog Embryo Teratogenesis Assay-Xenopus and an exogenous metabolic activation system to evaluate the developmental toxicity of diphenylhydantoin. ( Bantle, JA; Fort, DJ, 1990) |
| " In this prospective, descriptive study four dosage regimens were investigated in 104 patients." | 1.28 | Clinical experience with phenytoin prophylaxis in severe preeclampsia. ( Lange, IR; Naugler, MA; Ryan, G, 1989) |
| "Dimethadione was given similarly on Days 11 and 12, or 12 and 13, in a dose (900 mg/kg ip) that was equimolar to 1000 mg/kg of trimethadione." | 1.28 | Inhibition of trimethadione and dimethadione teratogenicity by the cyclooxygenase inhibitor acetylsalicylic acid: a unifying hypothesis for the teratologic effects of hydantoin anticonvulsants and structurally related compounds. ( Greco, GS; Nagai, MK; Wells, PG, 1989) |
| " A dose-response study was followed by a detailed teratological study using a single dose of 3 mg." | 1.28 | Teratogenic effects of phenytoin on chick embryos. ( Shah, GL; Singh, M, 1989) |
| "Phenytoin, 55 mg/kg, was administered intraperitoneally (ip) to pregnant CD-1 mice at 0900 hr on gestational days 12 and 13." | 1.28 | Enhancement of murine phenytoin teratogenicity by the gamma-glutamylcysteine synthetase inhibitor L-buthionine-(S,R)-sulfoximine and by the glutathione depletor diethyl maleate. ( Helston, LM; Wells, PG; Wong, M, 1989) |
| " Pharmacokinetic interactions between antiepileptic drugs may lead to considerable fluctuation in plasma drug concentration, and monotherapy is often preferable." | 1.27 | Pharmacokinetics of antiepileptic drugs. ( Neuvonen, PJ; Tokola, RA, 1983) |
| " In the first experiment, the lower end of the malformation dose-response curves for diphenylhydantoin (DPH), trimethadione (TMD) and phenobarbital (PB) were established." | 1.27 | Fetal anticonvulsant syndrome in rats: dose- and period-response relationships of prenatal diphenylhydantoin, trimethadione and phenobarbital exposure on the structural and functional development of the offspring. ( Vorhees, CV, 1983) |
| " Her plasma phenytoin level at the time had dropped to 2 microgram/ml despite a recent dosage increase." | 1.27 | Impaired phenytoin bioavailability secondary to cisplatinum, vinblastine, and bleomycin. ( Caldwell, KC; Lewis, FB; Lobell, M; Perri, R; Sawchuk, RA; Sylvester, RK, 1984) |
| " Depending on its pharmacokinetic parameters, each drug effect has a different onset, intensity, and time course." | 1.27 | Clinical pharmacokinetics of drugs used in the treatment of status epilepticus. ( Baars, AM; van der Dries, A; van der Kleijn, E; Vree, TB, 1983) |
| "Only when the epilepsy is uncontrolled despite high plasma concentrations which cannot be raised because of side effects, a second drug should be given." | 1.27 | [Pharmacotherapy of epilepsy--current problems and controversies]. ( Schmidt, D, 1983) |
| "Phenobarbital may cause hyperactivity, behavioral problems, sedation, and even dementia; these effects are dose related to some extent." | 1.27 | Side effects of phenobarbital and phenytoin during long-term treatment of epilepsy. ( Iivanainen, M; Savolainen, H, 1983) |
| " Maternal Balb/c mice were dosed by gavage on gestation days 9 through 18 with 0, 20, 40, or 60 mg/kg DPH." | 1.27 | Humoral immune dysfunction as a result of prenatal exposure to diphenylhydantoin: correlation with the occurrence of physical defects. ( Chapman, JR; Roberts, DW, 1984) |
| "The objective of this investigation was to study the teratogenic effects of dosage levels and time of administration of three anticonvulsant drugs (carbamazepine [CMZ], sodium valproate [NaV], and diphenylhydantoin [DPH]) on craniofacial development in the CD-1 mouse fetus." | 1.27 | Teratogenic effects of dosage levels and time of administration of carbamazepine, sodium valproate, and diphenylhydantoin on craniofacial development in the CD-1 mouse fetus. ( Eluma, FO; Hayes, TG; Paulson, RB; Sucheston, ME, 1984) |
| " In control animals, maternal plasma corticosterone levels were elevated soon after dosing but gradually declined, except for an apparent circadian rhythm effect seen in samples obtained in the afternoon." | 1.27 | Alterations in maternal plasma corticosterone levels following treatment with phenytoin. ( Grafton, TF; Hansen, DK; Holson, RR; Sullivan, PA, 1988) |
| " In 48% of the patients the drug dosage had to be increased to combat the increased seizure frequency." | 1.27 | Serum phenytoin during pregnancy, labor and puerperium. ( Bardy, AH; Hiilesmaa, VK; Teramo, KA, 1987) |
| "Acetaminophen pretreatment caused a threefold increase in phenytoin-induced fetal cleft palates without increasing resorptions." | 1.27 | Pharmacological studies on the potentiation of phenytoin teratogenicity by acetaminophen. ( Lum, JT; Wells, PG, 1986) |
| "The effects of pregnancy on seizure excitability as well as antiepileptic drug disposition and efficacy were studied in the mouse during late gestation." | 1.27 | Effects of pregnancy on seizure threshold and the disposition and efficacy of antiepileptic drugs in the mouse. ( Kuhnz, W; Löscher, W; Nau, H, 1985) |
| " The mechanisms responsible for these effects have not been elucidated and possibly include decreased bioavailability or compliance, increased metabolic clearance, or decreased plasma protein binding." | 1.27 | Effects of pregnancy on antiepileptic drug utilization. ( Levy, RH; Yerby, MS, 1985) |
| "Status epilepticus is an acute, life-threatening potential complication of pregnancy in the epileptic patient." | 1.27 | Refractory status epilepticus in pregnancy. A case report. ( Field, DR; Grunert, GM, 1985) |
| "Status epilepticus is a serious emergency that rarely complicates the management of the pregnant patient with seizure disorders." | 1.27 | Status epilepticus in pregnancy. A case report. ( Fougner, AC; Seltzer, VL; Wilson, SJ, 1985) |
| "Phenytoin was also concentrated in nonperfused placental tissue." | 1.27 | The pharmacokinetics of phenytoin in perfused human placenta. ( Miller, RK; Shah, YG, 1985) |
| "Electroconvulsive seizures administered during the period of fetal benzodiazepine (BZ) binding site proliferation (days 16, 18 and 20 in gestation) significantly decreased the density of cerebral cortical benzodiazepine binding sites in exposed pups up to 21 days postnatal age." | 1.26 | Prenatal exposure to electroconvulsive seizures and phenytoin: development of benzodiazepine binding sites, reflex behaviors and seizure thresholds in exposed offspring. ( Gallager, DW; Wakeman, EA, 1982) |
| "The incidence of malformations in fetal mice exposed to phenytoin depends on drug dosage and the strain of mice." | 1.26 | Teratogenic effects of anticonvulsants. ( Paulson, GW; Paulson, RB, 1981) |
| "All had central sleep apnea, three had hypoventilation, and none had obstructive apnea observed on polygraphic recordings." | 1.26 | Episodic complete airway obstruction in infants. ( Kelly, DH; Shannon, DC, 1981) |
| "Phenytoin is a drug of considerable medical use, but very little is known about the various possible intermediate steps involved in its action." | 1.26 | Phenytoin administration to pregnant mice: a mutagenic action? ( Ehrensperger, M; Lombard, MN; Petter, C, 1981) |
| "This study showed that the LD50 values for morphine sulfate, cobalt chloride, and phenytoin sodium did not vary significantly on Day 9 of gestation in CF-1 mice when compared to values of nongravid animals." | 1.26 | Nonvariance of LD50 values of drugs in gravid and nongravid mice. ( Gautieri, RF; Mahalik, MP; McDevitt, JM; Russell, JA, 1980) |
| "22 patients with severe preeclampsia-eclampsia were treated in our Intensive Care Unit from 1972 to 1978." | 1.26 | [Intensive care of severe preeclampsia-eclampsia. A report on 22 cases (author's transl)]. ( Larsen, R; Radke, J; Turner, E, 1980) |
| " Within the therapeutic range, small increments in dosage resulted in large increments in plasma DPH levels, and in the postpartum period high levels of DPH were encountered if the dosage was not reduced." | 1.26 | Phenytoin metabolism in pregnancy. ( Emery, MG; Kochenour, NK; Sawchuk, RJ, 1980) |
| "The mothers of children who developed cancer reported about 25% more illnesses during pregnancy than mothers of healthy control children." | 1.26 | Childhood cancer and drugs in pregnancy. ( Draper, GJ; Sanders, BM, 1979) |
| " Although phenytoin dosage remained relatively constant, plasma phenytoin concentrations during pregnancy were significantly lower than nonpregnant concentrations." | 1.26 | Hematologic effects of phenytoin therapy during pregnancy. ( Ramsay, RE; Strauss, RG; Wilder, BJ; Willmore, LJ, 1978) |
| " Monitoring plasma concentrations may lead to adaptations of the choice of the drug and of the dosage regimen." | 1.26 | Kinetics of drug interactions in the treatment of epilepsy. ( Guelen, P; Knop, H; Schobten, F; van der Kleijn, E; Vree, T; Westenberg, H, 1978) |
| "A case is presented of fetal teratogenic damage from an unusually high maternal dosage of diphenylhydantoin, 600 mg daily, to a 40-kg woman throughout pregnancy." | 1.26 | Diphenylhydantoin teratogenicity in man. ( Chang, MJ; Chi, CC; Tsai, CJ; Yang, TS, 1978) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 488 (64.46) | 18.7374 |
| 1990's | 135 (17.83) | 18.2507 |
| 2000's | 85 (11.23) | 29.6817 |
| 2010's | 37 (4.89) | 24.3611 |
| 2020's | 12 (1.59) | 2.80 |
| Authors | Studies |
|---|---|
| Ritchie, HE | 1 |
| Abela, D | 4 |
| Ababneh, D | 2 |
| Howe, AM | 5 |
| Farrell, E | 1 |
| Hegedus, E | 1 |
| Adams, J | 1 |
| Janulewicz, PA | 1 |
| Macklin, EA | 1 |
| Dhillon, R | 1 |
| Phillips, C | 1 |
| Schomer, DL | 1 |
| Tosches, WA | 1 |
| Carlson, JM | 1 |
| Holmes, LB | 15 |
| Kurt, A | 1 |
| Salihoglu, AK | 1 |
| Ayar, A | 1 |
| Roberti, R | 1 |
| Rocca, M | 1 |
| Iannone, LF | 1 |
| Gasparini, S | 1 |
| Pascarella, A | 1 |
| Neri, S | 1 |
| Cianci, V | 1 |
| Bilo, L | 1 |
| Russo, E | 1 |
| Quaresima, P | 1 |
| Aguglia, U | 1 |
| Di Carlo, C | 1 |
| Ferlazzo, E | 1 |
| Tsukiboshi, Y | 1 |
| Ogata, A | 1 |
| Noguchi, A | 1 |
| Mikami, Y | 1 |
| Yokota, S | 1 |
| Ogata, K | 1 |
| Yoshioka, H | 1 |
| Du, Y | 1 |
| Xu, Q | 1 |
| Lin, J | 1 |
| Gong, J | 1 |
| Xia, N | 1 |
| Zhu, Z | 1 |
| Wang, X | 1 |
| Zheng, R | 1 |
| Xu, H | 1 |
| Bromley, R | 1 |
| Adab, N | 1 |
| Bluett-Duncan, M | 1 |
| Clayton-Smith, J | 4 |
| Christensen, J | 2 |
| Edwards, K | 1 |
| Greenhalgh, J | 1 |
| Hill, RA | 1 |
| Jackson, CF | 1 |
| Khanom, S | 1 |
| McGinty, RN | 1 |
| Tudur Smith, C | 1 |
| Pulman, J | 1 |
| Marson, AG | 1 |
| Kardoost, M | 1 |
| Hajizadeh-Saffar, E | 1 |
| Ghorbanian, MT | 1 |
| Ghezelayagh, Z | 1 |
| Pooshang Bagheri, K | 1 |
| Behdani, M | 1 |
| Habibi-Anbouhi, M | 1 |
| Keni, RR | 1 |
| Jose, M | 1 |
| A S, R | 1 |
| Baishya, J | 1 |
| Sankara Sarma, P | 1 |
| Thomas, SV | 2 |
| Li, ZR | 1 |
| Wang, CY | 1 |
| Zhu, X | 1 |
| Jiao, Z | 1 |
| Kaplan, YC | 1 |
| Demir, O | 1 |
| Kakumoto, M | 1 |
| Shimokawa, K | 1 |
| Ueshima, S | 1 |
| Hira, D | 1 |
| Okano, T | 1 |
| Idota, N | 1 |
| Shintani-Ishida, K | 1 |
| Ichioka, H | 1 |
| Kondou, H | 1 |
| Ikegaya, H | 1 |
| Hegde, A | 1 |
| Kaur, A | 1 |
| Sood, A | 1 |
| Dhanorkar, M | 1 |
| Varma, HT | 1 |
| Singh, G | 1 |
| Saini, AG | 1 |
| Kumar, P | 1 |
| Dong, XY | 1 |
| Bai, CB | 1 |
| Nao, JF | 1 |
| Lavaf, M | 1 |
| Simbar, M | 1 |
| Mojab, F | 1 |
| Alavi Majd, H | 1 |
| Samimi, M | 1 |
| Tomson, T | 5 |
| Battino, D | 3 |
| Bonizzoni, E | 1 |
| Craig, J | 1 |
| Lindhout, D | 4 |
| Perucca, E | 5 |
| Sabers, A | 1 |
| Vajda, F | 1 |
| Thangaratinam, S | 1 |
| Marlin, N | 1 |
| Newton, S | 1 |
| Weckesser, A | 1 |
| Bagary, M | 1 |
| Greenhill, L | 1 |
| Rikunenko, R | 1 |
| D'Amico, M | 1 |
| Rogozińska, E | 1 |
| Kelso, A | 1 |
| Hard, K | 1 |
| Coleman, J | 1 |
| Moss, N | 1 |
| Roberts, T | 1 |
| Middleton, L | 1 |
| Dodds, J | 1 |
| Pullen, A | 1 |
| Eldridge, S | 1 |
| Pirie, A | 1 |
| Denny, E | 1 |
| McCorry, D | 1 |
| Khan, KS | 1 |
| Cohen, MJ | 2 |
| Meador, KJ | 5 |
| May, R | 1 |
| Loblein, H | 1 |
| Conrad, T | 1 |
| Baker, GA | 4 |
| Bromley, RL | 2 |
| Kalayjian, LA | 4 |
| Kanner, A | 3 |
| Liporace, JD | 4 |
| Pennell, PB | 4 |
| Privitera, M | 3 |
| Loring, DW | 5 |
| Wilson, KL | 1 |
| Alexander, JM | 2 |
| Babu, S | 1 |
| Agarwal, N | 2 |
| Fillekes, Q | 1 |
| Muro, EP | 1 |
| Chunda, C | 1 |
| Aitken, S | 1 |
| Kisanga, ER | 1 |
| Kankasa, C | 1 |
| Thomason, MJ | 1 |
| Gibb, DM | 1 |
| Walker, AS | 1 |
| Burger, DM | 1 |
| Nilsson, MF | 3 |
| Ritchie, H | 2 |
| Webster, WS | 7 |
| Ansary, A | 1 |
| Ibhanesebhor, S | 1 |
| Manjunatha, C | 1 |
| Verrotti, A | 1 |
| Scaparrotta, A | 1 |
| Cofini, M | 1 |
| Chiarelli, F | 1 |
| Tiboni, GM | 4 |
| Orup, HI | 2 |
| Deutsch, CK | 1 |
| Soysal, H | 2 |
| Doğan, Z | 1 |
| Kamışlı, Ö | 1 |
| Vanya, M | 1 |
| Devosa, I | 1 |
| Szok, D | 1 |
| Bártfai, G | 1 |
| Hirashima, R | 1 |
| Michimae, H | 1 |
| Takemoto, H | 1 |
| Sasaki, A | 1 |
| Kobayashi, Y | 1 |
| Itoh, T | 1 |
| Tukey, RH | 1 |
| Fujiwara, R | 1 |
| Jose, L | 1 |
| Binila, C | 1 |
| Chandy, SJ | 1 |
| Mathews, JE | 1 |
| Mathews, KP | 1 |
| Domínguez-Fuentes, B | 1 |
| García-Gil, D | 1 |
| Romero-Palacios, A | 1 |
| Sánchez-Crespo, JM | 1 |
| García-Arjona, R | 1 |
| Navarro-Navarro, J | 1 |
| Liu, Y | 1 |
| Yohrling, GJ | 1 |
| Wang, Y | 1 |
| Hutchinson, TL | 1 |
| Brenneman, DE | 1 |
| Flores, CM | 1 |
| Zhao, B | 1 |
| Browning, N | 2 |
| Combs-Cantrell, DT | 1 |
| Cohen, M | 1 |
| Azzato, EM | 1 |
| Chen, RA | 1 |
| Wacholder, S | 1 |
| Chanock, SJ | 1 |
| Klebanoff, MA | 1 |
| Caporaso, NE | 1 |
| Houser, MV | 1 |
| Hennessy, MD | 1 |
| Howard, BC | 1 |
| Gallop, K | 1 |
| Mao, XY | 1 |
| Tang, SJ | 1 |
| Greene, S | 1 |
| Kerr, F | 1 |
| Koutsogiannis, Z | 1 |
| Robinson, J | 1 |
| Duley, L | 4 |
| Henderson-Smart, DJ | 1 |
| Chou, D | 1 |
| Gavin, C | 1 |
| Khan, MK | 1 |
| Carlsson, K | 1 |
| Sugaya, A | 1 |
| Nakamagoe, K | 1 |
| Okoshi, Y | 1 |
| Obata-Yasuoka, M | 1 |
| Tamaoka, A | 1 |
| Stead, LG | 1 |
| Abramov, JP | 3 |
| Wells, PG | 21 |
| Unur, E | 1 |
| Düzler, A | 1 |
| Karaca, O | 1 |
| Ekinci, N | 1 |
| Forcelli, PA | 1 |
| Gale, K | 1 |
| Kondratyev, A | 1 |
| Fogleman, CD | 1 |
| Ono, T | 1 |
| Moshé, SL | 1 |
| Galanopoulou, AS | 1 |
| Zhang, LL | 1 |
| Zeng, LN | 1 |
| Li, YP | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Effect of Phenytoin on the Pharmacokinetics of Nevirapine and the Development of Nevirapine Resistance After a Single Dose Nevirapine (VIramune®), Which is Part of ARV Prophylaxis for PMTCT in Moshi, TAnzania, and in Lusaka, Zambia (VITA2 Trial)[NCT01187719] | Phase 2 | 66 participants (Actual) | Interventional | 2010-05-31 | Completed | ||
| Neurodevelopmental Effects of Antiepileptic Drugs II: the NEAD Study[NCT00021866] | 331 participants (Actual) | Observational | 2000-09-30 | Completed | |||
| Effects and Consequences for Mother and Child From Treatment for Depression, A Prospective Randomized, Placebo- Controlled, Trial With Internet-based Cognitive Behavior Therapy and Sertraline or Placebo for Moderate Depression in Pregnancy[NCT02185547] | Phase 4 | 17 participants (Actual) | Interventional | 2016-02-21 | Terminated (stopped due to Difficulties in recruiting participants.) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
87 reviews available for phenytoin and Pregnancy
| Article | Year |
|---|---|
Status epilepticus in pregnancy: a literature review and a protocol proposal.
Topics: Anticonvulsants; Female; Humans; Levetiracetam; Phenytoin; Pregnancy; Review Literature as Topic; St | 2022 |
Monotherapy treatment of epilepsy in pregnancy: congenital malformation outcomes in the child.
Topics: Child; Cohort Studies; Epilepsy; Female; Humans; Lamotrigine; Male; Phenytoin; Pregnancy; Prenatal E | 2023 |
Population Pharmacokinetics of Levetiracetam: A Systematic Review.
Topics: Adult; Anticonvulsants; Carbamazepine; Child; Female; Humans; Infant, Newborn; Levetiracetam; Phenyt | 2021 |
Use of Phenytoin, Phenobarbital Carbamazepine, Levetiracetam Lamotrigine and Valproate in Pregnancy and Breastfeeding: Risk of Major Malformations, Dose-dependency, Monotherapy vs Polytherapy, Pharmacokinetics and Clinical Implications.
Topics: Anticonvulsants; Breast Feeding; Carbamazepine; Epilepsy; Female; Humans; Lamotrigine; Levetiracetam | 2021 |
Seizures and intracranial hemorrhage.
Topics: Anticonvulsants; Carbamazepine; Congenital Abnormalities; Eclampsia; Epilepsy; Female; Folic Acid; H | 2013 |
Developmental neurotoxicity and anticonvulsant drugs: a possible link.
Topics: Animals; Anticonvulsants; Breast Feeding; Carbamazepine; Cognition Disorders; Developmental Disabili | 2014 |
Effects of phenytoin and lamotrigine treatment on serum BDNF levels in offsprings of epileptic rats.
Topics: Animals; Brain-Derived Neurotrophic Factor; Cerebral Cortex; Disease Models, Animal; Electroencephal | 2016 |
[Preconceptional and perinatal challenges of pregnancy in women with epilepsy].
Topics: Adult; Amines; Anticonvulsants; Benzodiazepines; Carbamazepine; Cyclohexanecarboxylic Acids; Epileps | 2016 |
Review article: phenytoin use and efficacy in the ED.
Topics: Administration, Oral; Adult; Anticonvulsants; Australia; Child; Drug Monitoring; Emergency Service, | 2010 |
Magnesium sulphate versus phenytoin for eclampsia.
Topics: Anticonvulsants; Clonazepam; Diazepam; Drug Combinations; Eclampsia; Female; Humans; Magnesium Sulfa | 2010 |
Diphenylhydantoin-induced severe yet reversible anemia during pregnancy.
Topics: Adult; Anemia; Anticonvulsants; Female; Humans; Phenytoin; Pregnancy; Pregnancy Complications, Hemat | 2010 |
Effects of intraperitoneal administration of the phenytoin on the skeletal system of rat fetus.
Topics: Abnormalities, Drug-Induced; Animals; Anticonvulsants; Body Weight; Bone and Bones; Embryo, Mammalia | 2011 |
Side effects of phenobarbital in epilepsy: a systematic review.
Topics: Anticonvulsants; Carbamazepine; Child; Cognition Disorders; Cohort Studies; Cross-Over Studies; Data | 2011 |
Teratogen-induced limb defects.
Topics: Chorionic Villi Sampling; Female; Humans; Limb Deformities, Congenital; Male; Misoprostol; Phenytoin | 2002 |
Epilepsy and pregnancy: maternal and fetal effects of phenytoin.
Topics: Adolescent; Epilepsy; Female; Humans; Phenytoin; Pregnancy; Pregnancy Complications | 2003 |
Magnesium sulphate versus phenytoin for eclampsia.
Topics: Anticonvulsants; Chlorpromazine; Drug Combinations; Eclampsia; Female; Humans; Magnesium Sulfate; Me | 2003 |
Impact of phenytoin therapy on the skin and skin disease.
Topics: Abnormalities, Drug-Induced; Adult; Anticonvulsants; Child; Connective Tissue Diseases; Drug Eruptio | 2004 |
Mechanisms regulating toxicant disposition to the embryo during early pregnancy: an interspecies comparison.
Topics: Animals; Biological Transport; Carbamazepine; Embryonic Development; Female; Humans; Maternal-Fetal | 2004 |
The relationship between cleft lip, maxillary hypoplasia, hypoxia and phenytoin.
Topics: Animals; Anticonvulsants; Cleft Lip; Female; Fetal Hypoxia; Humans; Maxilla; Organogenesis; Phenytoi | 2006 |
Embryonic cardiac arrhythmia and generation of reactive oxygen species: common teratogenic mechanism for IKr blocking drugs.
Topics: Abnormalities, Drug-Induced; Animals; Anti-Arrhythmia Agents; Anticonvulsants; Arrhythmias, Cardiac; | 2007 |
Antiepileptic drugs as human teratogens.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Carbamazepine; Epilepsy; Female; Humans; Phenobarbital | 2008 |
Antiarrhythmic drug therapy during pregnancy.
Topics: Adrenergic beta-Antagonists; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Breast Feeding; Digitalis | 1983 |
Theophylline reassessed.
Topics: Acidosis; Aging; Allopurinol; Animals; Anti-Bacterial Agents; Breast Feeding; Bronchodilator Agents; | 1984 |
The effects of drugs on the distribution and metabolism of thyroid hormones.
Topics: Animals; Antithyroid Agents; Carbamazepine; Carcinogens; Female; Heparin; Hormones; Humans; Male; Ph | 1981 |
Mechanisms of teratogenesis.
Topics: Aminopterin; Androgens; Animals; Antithyroid Agents; Chromosome Aberrations; Coumarins; Diethylstilb | 1984 |
Fetal preventive medicine: teratogens and the unborn baby.
Topics: Abnormalities, Drug-Induced; Dronabinol; Drug Evaluation; Ethanol; Female; Heroin; Hormones; Hot Tem | 1981 |
The clinical pharmacology of antiepileptic drugs.
Topics: Adult; Anticonvulsants; Benzodiazepines; Carbamazepine; Drug Interactions; Ethosuximide; Female; Hal | 1984 |
Cardiovascular problems of the newborn and their etiologies.
Topics: Amphetamines; Animals; Cardiovascular Diseases; Estrogens; Ethanol; Female; Fetal Hypoxia; Heart Def | 1983 |
Clinical pharmacokinetics of antiepileptic drugs in adults.
Topics: Adult; Aging; Anticonvulsants; Carbamazepine; Clonazepam; Diazepam; Disease; Ethosuximide; Female; H | 1980 |
The epileptic mother and her child.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Breast Feeding; Carbamazepine; Epilepsy; Female; Fetal | 1982 |
An overview of perinatal clinical pharmacology.
Topics: Abnormalities, Drug-Induced; Analgesics; Bupivacaine; Carbamazepine; Chloramphenicol; Diazepam; Digo | 1981 |
Biochemical and molecular teratology of fetal hydantoin syndrome.
Topics: Abnormalities, Drug-Induced; Animals; Cleft Lip; Disease Models, Animal; Epilepsy; Face; Female; Fet | 1994 |
Pregnancy, teratogenesis, and epilepsy.
Topics: Abnormalities, Drug-Induced; Animals; Anticonvulsants; Epilepsy; Female; Fetus; Humans; Infant, Newb | 1994 |
Developmental neurotoxicity induced by therapeutic and illicit drugs.
Topics: Animals; Brain Diseases; Female; Humans; Illicit Drugs; Isotretinoin; Learning Disabilities; Methamp | 1994 |
Eclampsia.
Topics: Diagnosis, Differential; Diazepam; Eclampsia; Female; Humans; Infant, Newborn; Magnesium Sulfate; Ne | 1994 |
Prenatal exposure to phenytoin, facial development, and a possible role for vitamin K.
Topics: Abnormalities, Drug-Induced; Adult; Anticonvulsants; Child; Chondrodysplasia Punctata; Face; Female; | 1995 |
[Phenytoin].
Topics: Anticonvulsants; Drug Monitoring; Female; Humans; Phenytoin; Pregnancy | 1995 |
Lymphoblastic lymphoma following prenatal exposure to phenytoin.
Topics: Anticonvulsants; Child; Child, Preschool; Female; Humans; Infant; Infant, Newborn; Male; Phenytoin; | 1996 |
Estimated magnitude of behavioral effects of phenytoin in rats and its reproducibility: a collaborative behavioral teratology study in Japan.
Topics: Animals; Behavior, Animal; Female; Japan; Phenytoin; Pregnancy; Rats; Rats, Sprague-Dawley; Teratolo | 1996 |
Pre-eclampsia/eclampsia: a literature review.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsants; Aspirin; Eclampsia; Female; Humans; Magnes | 1998 |
Clinical management of established pre-eclampsia and gestational hypertension: an anaesthetist's perspective.
Topics: Acute Kidney Injury; Anesthesia, Conduction; Anesthesia, General; Anesthesia, Obstetrical; Anticonvu | 1999 |
Magnesium sulphate versus phenytoin for eclampsia.
Topics: Anticonvulsants; Eclampsia; Female; Humans; Magnesium Sulfate; Phenytoin; Pregnancy | 2000 |
Pure red cell aplasia.
Topics: Anticonvulsants; Antitubercular Agents; Autoimmune Diseases; Azathioprine; Bone Marrow Cells; Fancon | 2000 |
Magnesium sulphate for eclampsia: putting the evidence into clinical practice.
Topics: Adult; Anticonvulsants; Diazepam; Eclampsia; Evidence-Based Medicine; Female; Humans; Magnesium Sulf | 2000 |
Class III antiarrhythmics and phenytoin: teratogenicity due to embryonic cardiac dysrhythmia and reoxygenation damage.
Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Embryo, Mammalian; Female; Humans; Phenytoin; | 2001 |
[Fetal hydantoin syndrome].
Topics: Anticonvulsants; Female; Fetal Diseases; Humans; Infant, Newborn; Phenytoin; Pregnancy | 2001 |
Treatment of epilepsy in 3 specialized populations.
Topics: Age Factors; Aged; Anticonvulsants; Carbamazepine; Child; Drug Interactions; Epilepsy; Female; Human | 2001 |
[Dysmorphisms and psychomotor retardation in infants of mothers treated with anticonvulsants in pregnancy].
Topics: Abnormalities, Drug-Induced; Adult; Anticonvulsants; Epilepsy, Tonic-Clonic; Female; Fetus; Humans; | 1979 |
The pharmacological treatment of epilepsy.
Topics: Anticonvulsants; Carbamazepine; Child, Preschool; Clonazepam; Drug Therapy, Combination; Epilepsies, | 1979 |
Perinatal pharmacology: placental transfer, fetal localization, and neonatal disposition of drugs.
Topics: Animals; Barbiturates; Blood; Female; Fetus; Humans; Hydrogen-Ion Concentration; Infant, Newborn; Ki | 1975 |
Drugs and chemicals associated with intrauterine growth deficiency.
Topics: Abnormalities, Drug-Induced; Adult; Aminopterin; Animals; Disease Models, Animal; Ethanol; Female; F | 1978 |
[Antiepileptics during pregnancy and lactation. Pharmacokinetic data].
Topics: Anticonvulsants; Bromides; Carbamazepine; Clonazepam; Diazepam; Ethosuximide; Female; Fetus; Humans; | 1979 |
Clinical pharmacokinetics of anticonvulsants.
Topics: Administration, Oral; Adult; Aged; Aging; Animals; Anticonvulsants; Carbamazepine; Child; Clonazepam | 1976 |
Plasma and tissue protein binding of drugs in pharmacokinetics.
Topics: Adrenal Cortex Hormones; Age Factors; Aging; Albumins; Animals; Anti-Bacterial Agents; Antibodies; A | 1976 |
Drug metabolism in the human neonate.
Topics: Adult; Animals; Barbiturates; Caffeine; Epoxy Compounds; Female; Humans; Infant, Newborn; Labor, Obs | 1975 |
Treatment of preeclampsia and eclampsia.
Topics: Antihypertensive Agents; Aspirin; Diazepam; Eclampsia; Female; Humans; Magnesium Sulfate; Phenytoin; | 1992 |
Prophylaxis of eclamptic seizures: current controversies.
Topics: Anticonvulsants; Clinical Trials as Topic; Eclampsia; Female; Humans; Magnesium Sulfate; Phenytoin; | 1992 |
Differences in phenytoin biotransformation and susceptibility to congenital malformations: a review.
Topics: Abnormalities, Drug-Induced; Animals; Biotransformation; Cytochrome P-450 Enzyme System; Disease Sus | 1991 |
A continuing controversy: magnesium sulfate in the treatment of eclamptic seizures.
Topics: Eclampsia; Female; Humans; Magnesium Sulfate; Phenytoin; Pregnancy; Seizures | 1990 |
Magnesium sulfate is the ideal anticonvulsant in preeclampsia-eclampsia.
Topics: Anticonvulsants; Drug Evaluation; Eclampsia; Female; Humans; Magnesium Sulfate; Phenytoin; Pre-Eclam | 1990 |
Valproic acid prenatal exposure. Association with lipomyelomeningocele.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adult; Anticonvulsants; Cleft Palate; Female; | 1989 |
[Problems of neurological drug therapy in pregnancy].
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Antiparkinson Agents; Carbamazepine; Chelating Agents; | 1989 |
Efficacy and adverse effects of antiepileptic drugs.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Carbamazepine; Epilepsy; Female; Humans; Phenobarbital | 1989 |
Neuroblastoma after prenatal exposure to phenytoin: cause and effect?
Topics: Bone and Bones; Female; Humans; Lymphocytes; Male; Neuroblastoma; Phenytoin; Pregnancy; Prenatal Exp | 1989 |
Cutaneous and immunologic reactions to phenytoin.
Topics: Carcinogens; Drug Eruptions; Drug Hypersensitivity; Female; Humans; Phenytoin; Pregnancy; Teratogens | 1988 |
Antiepileptic drugs in adolescents.
Topics: Adaptation, Psychological; Adolescent; Adult; Anticonvulsants; Carbamazepine; Child; Clonazepam; Dru | 1987 |
Current concepts. Seizure disorders and pregnancy.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Carbamazepine; Drug Administration Schedule; Epilepsy; | 1985 |
[Pharmacologic problems with teratogenic drugs].
Topics: Abnormalities, Drug-Induced; Adrenal Cortex Hormones; Anesthetics; Anti-Arrhythmia Agents; Anticonvu | 1985 |
Hereditary epidermolysis bullosa.
Topics: Adult; Animals; Child; Child, Preschool; Chloroquine; Dogs; Epidermolysis Bullosa; Female; Humans; I | 1985 |
Utility of clinical chemical determinations of drug concentrations in biological fluids.
Topics: Adult; Allopurinol; Antipyrine; Ataxia; Chemistry, Clinical; Chromatography, Gas; Coffee; Desipramin | 1971 |
Advances in pharmacogenetics.
Topics: Alcohol Oxidoreductases; Catalase; Cholinesterases; Dicumarol; Diseases in Twins; Drug Hypersensitiv | 1973 |
[Thyroid hormone-binding protein and abnormalities of its function].
Topics: Estrogens; Female; Heart Diseases; Humans; Immunoelectrophoresis; Liver Diseases; Nephrosis; Phenyto | 1968 |
Recent progress in pharmacogenetics.
Topics: Adult; Aged; Alcohol Oxidoreductases; Antipyrine; Asian People; Child, Preschool; Cholinesterases; C | 1969 |
Recent progress in pharmacogenetics.
Topics: Adult; Antipyrine; Cyanides; Dicumarol; Erythrocytes; Ethnicity; Female; Glucosephosphate Dehydrogen | 1969 |
[Digitalis medication before, during and after operations].
Topics: Adult; Age Factors; Cardiomegaly; Digitalis Glycosides; Electrocardiography; Female; Heart Failure; | 1970 |
Drug metabolism in the human fetus and newborn infant.
Topics: Aminobenzoates; Anti-Bacterial Agents; Bilirubin; Diazepam; Electron Transport; Endoplasmic Reticulu | 1972 |
Adverse hematologic effects of drugs.
Topics: Anemia, Hemolytic; Anemia, Macrocytic; Anti-Bacterial Agents; Anticonvulsants; Antidepressive Agents | 1972 |
Drug-induced cancer.
Topics: Alkylating Agents; Animals; Carcinogens; Diethylstilbestrol; Drug-Related Side Effects and Adverse R | 1972 |
Pharmacogenetics.
Topics: Analgesics; Anemia, Hemolytic; Anesthetics; Apnea; Bone Marrow Diseases; Child; Child, Preschool; Ch | 1972 |
[Teratogenic and mutagenic effects of anticonvulsive and psychotropic drugs (review of the literature)].
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Animals; Anticonvulsants; Antidepressive Agent | 1972 |
Host factors in the aetiology of periodontal disease.
Topics: Aged; Animals; Antibody Formation; Antigen-Antibody Complex; Complement System Proteins; Dental Occl | 1973 |
Anticonvulsants during pregnancy: a danger to the developing fetus?
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Barbiturates; Blood Coagulation Disorders; Chromosome | 1974 |
Drug excretion in breast milk.
Topics: Anti-Bacterial Agents; Barbiturates; Biological Transport, Active; Breast; Breast Feeding; Caffeine; | 1974 |
Anticonvulsant drugs. II. Clinical pharmacological and therapeutic aspects.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Blood Coagulation Disorders; Cerebellum; Drug Interact | 1972 |
Anticonvulsant therapy and serum folate.
Topics: Adolescent; Adult; Anticonvulsants; Child; Child, Preschool; Depression, Chemical; Epilepsy; Female; | 1969 |
Periodontal disease.
Topics: Adult; Ascorbic Acid Deficiency; Bone Resorption; Child; Dental Deposits; Dental Plaque; Endotoxins; | 1971 |
Advances in toxicology.
Topics: Abnormalities, Drug-Induced; Animals; Antidepressive Agents; Barbiturates; Cannabis; Diazepam; Drug | 1971 |
29 trials available for phenytoin and Pregnancy
| Article | Year |
|---|---|
Comparison of honey and phenytoin (PHT) cream effects on intensity of pain and episiotomy wound healing in nulliparous women.
Topics: Adolescent; Adult; Episiotomy; Female; Honey; Humans; Pain, Postoperative; Phenytoin; Pregnancy; Wou | 2017 |
AntiEpileptic drug Monitoring in PREgnancy (EMPiRE): a double-blind randomised trial on effectiveness and acceptability of monitoring strategies.
Topics: Anticonvulsants; Carbamazepine; Double-Blind Method; Drug Monitoring; Epilepsy; Female; Humans; Lamo | 2018 |
Effect of 7 days of phenytoin on the pharmacokinetics of and the development of resistance to single-dose nevirapine for perinatal HIV prevention: a randomized pilot trial.
Topics: Adult; Anti-HIV Agents; Anticonvulsants; Drug Interactions; Drug Resistance, Viral; Female; Half-Lif | 2013 |
Fetal antiepileptic drug exposure and cognitive outcomes at age 6 years (NEAD study): a prospective observational study.
Topics: Adult; Anticonvulsants; Child; Child Development; Child, Preschool; Cognition; Epilepsy; Female; Hum | 2013 |
Prophylactic phenytoin does not improve cerebral edema or survival in acute liver failure--a controlled clinical trial.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Brain Edema; Epilepsy; Female; Humans; Liver Failure, Acut | 2004 |
Evaluation of antiepileptic drugs in pregnancy in a Jordanian army hospital.
Topics: Abnormalities, Drug-Induced; Adult; Anticonvulsants; Carbamazepine; Clinical Protocols; Drug Monitor | 2005 |
In utero antiepileptic drug exposure: fetal death and malformations.
Topics: Abnormalities, Drug-Induced; Adult; Anticonvulsants; Carbamazepine; Cognition; Female; Fetal Death; | 2006 |
[Anti-epileptic agents during pregnancy. A prospective study on the course of pregnancy, malformations and child development].
Topics: Abnormalities, Drug-Induced; Abortion, Spontaneous; Adult; Akathisia, Drug-Induced; Anencephaly; Ant | 1983 |
Comparison of sodium valproate and phenytoin as single drug treatment in epilepsy.
Topics: Adolescent; Adult; Aged; Child; Epilepsy; Female; Humans; Male; Middle Aged; Phenytoin; Pregnancy; T | 1981 |
Does magnesium sulfate affect the length of labor induction in women with pregnancy-associated hypertension?
Topics: Adolescent; Adult; Anticonvulsants; Cesarean Section; Chi-Square Distribution; Chronic Disease; Fema | 1995 |
The feasibility of a control population for a randomized control trial of seizure prophylaxis in the hypertensive disorders of pregnancy.
Topics: Anticonvulsants; Antihypertensive Agents; Diazepam; Feasibility Studies; Female; Humans; Magnesium S | 1995 |
Which anticonvulsant for women with eclampsia? Evidence from the Collaborative Eclampsia Trial.
Topics: Adult; Diazepam; Eclampsia; Female; Humans; Infant, Newborn; Magnesium Sulfate; Phenytoin; Pregnancy | 1995 |
A comparison of magnesium sulfate with phenytoin for the prevention of eclampsia.
Topics: Adolescent; Adult; Analysis of Variance; Eclampsia; Female; Humans; Hypertension; Infant, Newborn; M | 1995 |
A simplified phenytoin regimen for preeclampsia.
Topics: Female; Humans; Phenytoin; Pre-Eclampsia; Pregnancy | 1994 |
Phenytoin versus magnesium sulfate in preeclampsia: a pilot study.
Topics: Adult; Female; Humans; Infusions, Intravenous; Magnesium Sulfate; Phenytoin; Pilot Projects; Pre-Ecl | 1993 |
Randomised study assessing the effect of phenytoin and magnesium sulphate on maternal cerebral circulation in eclampsia using transcranial Doppler ultrasound.
Topics: Adolescent; Adult; Anticonvulsants; Blood Flow Velocity; Blood Pressure; Cerebral Arteries; Cerebrov | 1996 |
Antiepileptic drug treatment in pregnancy: drug side effects in the neonate and neurological outcome.
Topics: Anticonvulsants; Child; Drug Monitoring; Epilepsy; Female; Follow-Up Studies; Humans; Nervous System | 1996 |
Findings in children exposed in utero to phenytoin and carbamazepine monotherapy: independent effects of epilepsy and medications.
Topics: Adult; Carbamazepine; Cohort Studies; Craniofacial Abnormalities; Epilepsy; Female; Fingers; Humans; | 1997 |
Effects of pregnancy on various pathways of human antiepileptic drug metabolism.
Topics: Adult; Anticonvulsants; Carbamazepine; Female; Humans; Phenytoin; Pregnancy; Pregnancy Complications | 1997 |
Efficacy of phenytoin in eclampsia.
Topics: Adolescent; Adult; Anticonvulsants; Eclampsia; Female; Humans; Phenytoin; Pregnancy; Seizures; Treat | 1997 |
Does magnesium sulfate given for prevention of eclampsia affect the outcome of labor?
Topics: Adult; Cesarean Section; Eclampsia; Female; Humans; Magnesium Sulfate; Obstetric Labor Complications | 1998 |
Teratological interaction between the bis-triazole antifungal agent fluconazole and the anticonvulsant drug phenytoin.
Topics: Abnormalities, Drug-Induced; Animals; Anticonvulsants; Antifungal Agents; Body Weight; Cleft Palate; | 1999 |
Efficacy of magnesium sulphate and phenytoin in the management of eclampsia.
Topics: Adult; Anticonvulsants; Birth Weight; Blood Pressure; Eclampsia; Female; Gestational Age; Hospitaliz | 1999 |
[Evaluation of antiepileptic therapy during pregnancy].
Topics: Adult; Anticonvulsants; Apgar Score; Drug Therapy, Combination; Epilepsy; Female; Humans; Phenobarbi | 2002 |
Effects of diuril and dilantin on blood glucose and insulin levels in late pregnancy.
Topics: Blood Glucose; Chlorothiazide; Dietary Carbohydrates; Female; Glucose Tolerance Test; Humans; Insuli | 1975 |
Magnesium sulfate versus phenytoin for seizure prophylaxis in pregnancy-induced hypertension.
Topics: Adult; Female; Humans; Hypertension; Magnesium Sulfate; Phenytoin; Pregnancy; Pregnancy Complication | 1991 |
Phenytoin sodium and magnesium sulphate in the management of eclampsia.
Topics: Adolescent; Adult; Dose-Response Relationship, Drug; Drug Evaluation; Eclampsia; Female; Humans; Hyp | 1990 |
Clonazepam--a clinical study of its effectiveness as an anticonvulsant.
Topics: Adolescent; Adult; Anticonvulsants; Benzodiazepinones; Child; Child, Preschool; Chlorobenzenes; Clin | 1973 |
Folate status and requirement in pregnancy.
Topics: Abortion, Spontaneous; Anemia, Macrocytic; Birth Weight; Diet; Female; Folic Acid; Folic Acid Defici | 1968 |
641 other studies available for phenytoin and Pregnancy
| Article | Year |
|---|---|
The effect of phenytoin on embryonic heart rate in Vivo.
Topics: Abnormalities, Drug-Induced; Animals; Female; Heart; Heart Rate; Hyperglycemia; Hypoxia; Phenytoin; | 2021 |
Neuropsychological effects in children exposed to anticonvulsant monotherapy during gestation: Phenobarbital, carbamazepine, and phenytoin.
Topics: Anticonvulsants; Carbamazepine; Child; Female; Humans; Intelligence Tests; Phenobarbital; Phenytoin; | 2022 |
An in vitro Study on the Contractility of Epileptic Myometrium and Effects of Antiepileptic Agents on Oxytocin-Induced Contractions of Myometrium Isolated from Absence Epileptic WAG/Rij Rats.
Topics: Animals; Anticonvulsants; Antifibrotic Agents; Dose-Response Relationship, Drug; Female; In Vitro Te | 2022 |
Sasa veitchii extracts protect phenytoin-induced cell proliferation inhibition in human lip mesenchymal cells through modulation of miR-27b-5p.
Topics: Cell Proliferation; Child; Cleft Lip; Cleft Palate; Female; Humans; MicroRNAs; Phenytoin; Pregnancy; | 2023 |
External validation of the AntiEpileptic Drug Monitoring in PREgnancy (EMPiRE) model for predicting seizures in pregnant women with epilepsy.
Topics: Anticonvulsants; Carbamazepine; Cohort Studies; Epilepsy; Female; Humans; Lamotrigine; Levetiracetam | 2023 |
Genotoxicity assessment of antiepileptic drugs (AEDs) in human embryonic stem cells.
Topics: Anticonvulsants; Carbamazepine; DNA Damage; Epilepsy; Female; Human Embryonic Stem Cells; Humans; La | 2019 |
Anti-epileptic drug and folic acid usage during pregnancy, seizure and malformation outcomes: Changes over two decades in the Kerala Registry of Epilepsy and Pregnancy.
Topics: Adult; Anticonvulsants; Carbamazepine; Female; Folic Acid; Humans; India; Lamotrigine; Levetiracetam | 2020 |
Effects of antiepileptic drugs' administration during pregnancy on the nerve cell proliferation and axonal outgrowth of human neuroblastoma SH-SY5Y nerve cells.
Topics: Anticonvulsants; Carbamazepine; Cell Line, Tumor; Cell Proliferation; Child; Epilepsy; Female; Human | 2021 |
Rapid infusion of excessive phenytoin: A newborn autopsy case.
Topics: Anticonvulsants; Autopsy; Cesarean Section; Female; Humans; Infant; Infant, Newborn; Phenytoin; Preg | 2021 |
Fetal Hydantoin Syndrome.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Administration, Oral; Epilepsy; Female; Humans | 2017 |
Clinical and radiological features of posterior reversible encephalopathy syndrome in patients with pre-eclampsia and eclampsia.
Topics: Adult; Anticonvulsants; Antihypertensive Agents; Brain; Diazepam; Eclampsia; Female; Humans; Labetal | 2017 |
Comparative risk of major congenital malformations with eight different antiepileptic drugs: a prospective cohort study of the EURAP registry.
Topics: Abnormalities, Drug-Induced; Adult; Anticonvulsants; Carbamazepine; Dose-Response Relationship, Drug | 2018 |
Fetal antiepileptic drug exposure and learning and memory functioning at 6 years of age: The NEAD prospective observational study.
Topics: Adult; Anticonvulsants; Carbamazepine; Child; Epilepsy; Female; Humans; Lamotrigine; Learning; Memor | 2019 |
Anonychia due to prenatal phenytoin exposure.
Topics: Anticonvulsants; Child; Epilepsy; Female; Humans; Nails, Malformed; Phenytoin; Pregnancy; Pregnancy | 2012 |
The effect on rat embryonic heart rate of Na+, K+, and Ca2+ channel blockers, and the human teratogen phenytoin, changes with gestational age.
Topics: Animals; Calcium Channel Blockers; Female; Gestational Age; Heart Rate, Fetal; Lidocaine; Nifedipine | 2013 |
Myoclonic seizures in a preterm baby: is this a presentation of venlafaxine withdrawal?
Topics: Antidepressive Agents; Cyclohexanols; Electroencephalography; Female; Humans; Infant, Newborn; Infan | 2014 |
Laser light scan analysis of the "anticonvulsant face".
Topics: Abnormalities, Drug-Induced; Adolescent; Anticonvulsants; Case-Control Studies; Child; Cohort Studie | 2014 |
Induction of the UDP-Glucuronosyltransferase 1A1 during the Perinatal Period Can Cause Neurodevelopmental Toxicity.
Topics: Animals; Animals, Newborn; Brain; Carbamazepine; Cell Movement; Enzyme Induction; Female; Gene Expre | 2016 |
Acenocoumarol and phenytoin toxicity in the presence of CYP2C9 mutation.
Topics: Acenocoumarol; Adult; Anticoagulants; Anticonvulsants; Aryl Hydrocarbon Hydroxylases; Cytochrome P-4 | 2008 |
[Posterior reversible leukoencephalopathy in a patient with postpartum eclampsia].
Topics: Adult; Anticonvulsants; Antihypertensive Agents; Brain; Brain Edema; Cesarean Section; Diazepam; Dru | 2008 |
Carisbamate, a novel neuromodulator, inhibits voltage-gated sodium channels and action potential firing of rat hippocampal neurons.
Topics: Action Potentials; Animals; Anticonvulsants; Carbamates; Cell Line; Cricetinae; Cricetulus; Dose-Res | 2009 |
Cognitive function at 3 years of age after fetal exposure to antiepileptic drugs.
Topics: Adult; Anticonvulsants; Carbamazepine; Child, Preschool; Cognition; Developmental Disabilities; Dose | 2009 |
Maternal EPHX1 polymorphisms and risk of phenytoin-induced congenital malformations.
Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Anticonvulsants; Confidence Intervals; Craniofacial | 2010 |
Valproic acid: long-term effects on children exposed in utero.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Carbamazepine; Cohort Studies; Contraindications; Dose | 2009 |
Vagal nerve stimulator use during pregnancy for treatment of refractory seizure disorder.
Topics: Anticonvulsants; Combined Modality Therapy; Epilepsy, Tonic-Clonic; Female; Humans; Phenytoin; Pregn | 2010 |
Effects of phenytoin on Satb2 and Hoxa2 gene expressions in mouse embryonic craniofacial tissue.
Topics: Animals; Anticonvulsants; Cleft Lip; Cleft Palate; Embryo, Mammalian; Face; Female; Fetus; Gene Expr | 2010 |
Phenytoin in toxin-induced seizures.
Topics: Anticonvulsants; Emergency Service, Hospital; Female; Humans; Phenytoin; Pregnancy; Seizures | 2010 |
The effect of drugs with ion channel-blocking activity on the early embryonic rat heart.
Topics: Abnormalities, Drug-Induced; Animals; Arrhythmias, Cardiac; Bradycardia; Embryo Culture Techniques; | 2010 |
Phenytoin.
Topics: Animals; Animals, Newborn; Anticonvulsants; Carcinogenicity Tests; Carcinogens; Female; Government R | 2004 |
Seizures in pregnancy/eclampsia.
Topics: Anticonvulsants; Antihypertensive Agents; Eclampsia; Female; Humans; Magnesium Sulfate; Oxygen Inhal | 2011 |
Embryoprotective role of endogenous catalase in acatalasemic and human catalase-expressing mouse embryos exposed in culture to developmental and phenytoin-enhanced oxidative stress.
Topics: Abnormalities, Drug-Induced; Animals; Catalase; Embryo Culture Techniques; Embryo, Mammalian; Embryo | 2011 |
Early postnatal exposure of rats to lamotrigine, but not phenytoin, reduces seizure threshold in adulthood.
Topics: Aging; Animals; Anticonvulsants; Disease Models, Animal; Epilepsy; Female; Lamotrigine; Male; Phenyt | 2011 |
Embryonic catalase protects against endogenous and phenytoin-enhanced DNA oxidation and embryopathies in acatalasemic and human catalase-expressing mice.
Topics: Abnormalities, Drug-Induced; Acatalasia; Animals; Anticonvulsants; Brain; Catalase; DNA; Dose-Respon | 2011 |
Magnesium sulfate and other anticonvulsants for women with preeclampsia.
Topics: Anticonvulsants; Clinical Trials as Topic; Evidence-Based Medicine; Female; Humans; Magnesium Sulfat | 2011 |
Carisbamate acutely suppresses spasms in a rat model of symptomatic infantile spasms.
Topics: Animals; Animals, Newborn; Anticonvulsants; Behavior, Animal; Carbamates; Disease Models, Animal; Do | 2011 |
Anaesthetic management of emergency caesarean section in a patient with seizures and likely raised intracranial pressure due to tuberculous meningitis.
Topics: Adult; Androstanols; Anesthesia, Obstetrical; Anesthetics, Inhalation; Anesthetics, Intravenous; Ant | 2011 |
Protective role of endogenous catalase in baseline and phenytoin-enhanced neurodevelopmental and behavioral deficits initiated in utero and in aged mice.
Topics: Aging; Animals; Behavior, Animal; Brain; Catalase; Female; Litter Size; Male; Maternal-Fetal Exchang | 2012 |
Dose-response effects of diphenylhydantoin on pregnant dams and embryo-fetal development in rats.
Topics: Animals; Body Weight; Bone and Bones; Cesarean Section; Dose-Response Relationship, Drug; Embryonic | 2012 |
Effect of prenatal exposure to anticonvulsant drugs on dermal ridge patterns of fingers.
Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Anticonvulsants; Child; Child, Preschool; Dermatogly | 2002 |
Fetal hydantoin syndrome with unilateral atypical cleft hand: additional evidence for vascular disruption.
Topics: Anticonvulsants; Blood Vessels; Child, Preschool; Facies; Female; Fetal Diseases; Hand Deformities, | 2002 |
Postpartum eclampsia.
Topics: Adult; Anticonvulsants; Antihypertensive Agents; Diagnosis, Differential; Eclampsia; Female; Humans; | 2002 |
Effects on toes from prenatal exposure to anticonvulsants.
Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Child; Child, Preschool; Epiphyses; Female; Fingers; | 2002 |
Chondrodysplasia punctata (CDP) with features of the tibia-metacarpal type and maternal phenytoin treatment during pregnancy.
Topics: Anticonvulsants; Carbamazepine; Child, Preschool; Chondrodysplasia Punctata; Craniofacial Abnormalit | 2002 |
[Pneumoencephaly and convulsive crises after inadvertent dural puncture in an obstetric patient].
Topics: Adult; Air; Anesthesia, Epidural; Anesthesia, Obstetrical; Anticonvulsants; Brain Diseases; Cesarean | 2002 |
Neurotoxic damage of granule cells in the dentate gyrus and the cerebellum and cognitive deficit following neonatal administration of phenytoin in mice.
Topics: Animals; Animals, Newborn; Anticonvulsants; Apoptosis; Body Weight; Cerebellum; Cognition Disorders; | 2002 |
Dilantin as anticonvulsant in eclampsia.
Topics: Adolescent; Adult; Anticonvulsants; Antihypertensive Agents; Delivery, Obstetric; Eclampsia; Female; | 2002 |
Evidence for Ras-dependent signal transduction in phenytoin teratogenicity.
Topics: Abnormalities, Drug-Induced; Animals; Anticonvulsants; DNA; DNA Mutational Analysis; Dose-Response R | 2002 |
Truncus arteriosus in fetal hydantoin syndrome - a new association?
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adult; Anticonvulsants; Epilepsy; Fatal Outcom | 2003 |
Craniofacial skeletal deviations following in utero exposure to the anticonvulsant phenytoin: monotherapy and polytherapy.
Topics: Abnormalities, Drug-Induced; Adolescent; Age Determination by Skeleton; Age Determination by Teeth; | 2003 |
Anticonvulsant teratogenesis 5: observer bias in a cohort study.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adult; Anticonvulsants; Boston; Cohort Studies | 2003 |
ANTI-EPILEPTIC DRUGS AND THE FOETUS.
Topics: Barbiturates; Epilepsy; Female; Fetal Diseases; Fetus; Phenobarbital; Phenytoin; Pregnancy; Pregnanc | 1963 |
THE INFANT WITH EPILEPSY.
Topics: Acetazolamide; Adrenocorticotropic Hormone; Anticonvulsants; Barbiturates; Birth Injuries; Classific | 1963 |
[ETIOLOGY AND THERAPY OF STATUS EPILEPTICUS].
Topics: Abortion, Septic; Anticonvulsants; Birth Injuries; Brain Injuries; Brain Neoplasms; Chloral Hydrate; | 1963 |
POLYNEURITIS OF PREGNANCY EFFECTIVELY MANAGED WITH DILANTIN. REPORT OF A CASE.
Topics: Drug Therapy; Female; Humans; Neuritis; Phenytoin; Pregnancy; Pregnancy Complications | 1964 |
ANESTHETIC MANAGEMENT OF THE PARTURIENT WITH INTRACRANIAL TUMOR.
Topics: Anesthesia; Anesthesia, Endotracheal; Anesthesia, Spinal; Anesthetics; Angiography; Brain Neoplasms; | 1964 |
[SEPARATION AND MICRODETERMINATION OF PHENOBARBITAL AND PHENYTOIN IN HUMAN MILK].
Topics: Milk, Human; Phenobarbital; Phenytoin; Pregnancy; Rare Diseases; Toxicology | 1965 |
[A CASE OF TRANSITORY MEDULLARY APLASIA IN A NEWBORN DUE TO ANTICONVULSANT DRUGS ADMINISTERED TO THE MOTHER DURING THE ENTIRE PREGNANCY].
Topics: Anemia; Anemia, Aplastic; Anticonvulsants; Humans; Infant, Newborn; Infant, Newborn, Diseases; Mothe | 1965 |
Additional investigation on the potentiation of phenytoin teratogenicity by fluconazole.
Topics: Animals; Chromatography, High Pressure Liquid; Cleft Palate; Dose-Response Relationship, Drug; Drug | 2003 |
Effect of prenatal phenytoin administration on the fine structure of rat myocardium and aorta.
Topics: Abnormalities, Drug-Induced; Administration, Oral; Animals; Anticonvulsants; Aorta, Thoracic; Female | 2003 |
Multiple congenital anomalies associated with in utero exposure of phenytoin: possible hypoxic ischemic mechanism?
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adult; Anticonvulsants; Epilepsy; Female; Gest | 2003 |
Interaction between anticonvulsants and human placental carnitine transporter.
Topics: Acetates; Amines; Aminoisobutyric Acids; Anticonvulsants; Carnitine; Carrier Proteins; Culture Techn | 2004 |
Effect of melatonin on neurobehavioral dysfunctions induced by intrauterine hypoxia in rats.
Topics: Analysis of Variance; Animals; Behavior, Animal; Female; Hypoxia; Melatonin; Oxidative Stress; Pheny | 2004 |
Effect of melatonin on biochemical variables induced by phenytoin in organs of mothers, foetuses and offsprings of rats.
Topics: Acetylglucosaminidase; Analysis of Variance; Animals; Animals, Newborn; Anticonvulsants; Female; Glu | 2004 |
Effect of melatonin and stobadine on maternal and embryofoetal toxicity in rats due to intrauterine hypoxia induced by phenytoin administration.
Topics: Abnormalities, Drug-Induced; Analysis of Variance; Animals; Animals, Newborn; Anticonvulsants; Body | 2004 |
Longer term outcome of children born to mothers with epilepsy.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Epilepsy; Fema | 2004 |
The correlation of deficits in IQ with midface and digit hypoplasia in children exposed in utero to anticonvulsant drugs.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Carbamazepine; Child; Cognition Disorders; Face; Facie | 2005 |
Phenytoin teratogenicity: hypoxia marker and effects on embryonic heart rhythm suggest an hERG-related mechanism.
Topics: Animals; Anticonvulsants; Cation Transport Proteins; Ether-A-Go-Go Potassium Channels; Female; Heart | 2005 |
Case report: Late-onset eclampsia presents as bilateral cortical blindness.
Topics: Adult; Anticonvulsants; Blindness, Cortical; Eclampsia; Epilepsy, Tonic-Clonic; Female; Headache; Hu | 2005 |
Correlation of susceptibility to 6-aminonicotinamide and hydrocortisone-induced cleft palate.
Topics: 6-Aminonicotinamide; Animals; Cleft Palate; Disease Susceptibility; Female; Fetus; Hydrocortisone; M | 2005 |
Maternal antioxidant supplementation does not reduce the incidence of phenytoin-induced cleft lip and related malformations in rats.
Topics: Abnormalities, Drug-Induced; Animals; Anticonvulsants; Antioxidants; Ascorbic Acid; Body Weight; Cle | 2005 |
A fragile site at 10q23 (FRA10A) in a phenytoin-exposed fetus: a case report and review of the literature.
Topics: Adult; Amniocentesis; Anticonvulsants; Cells, Cultured; Chromosome Deletion; Chromosome Fragile Site | 2005 |
Phenytoin induced oxidative stress in pre- and postnatal rat development - effect of vitamin E on selective biochemical variables.
Topics: Acetylglucosaminidase; Animals; Animals, Newborn; Anticonvulsants; Antioxidants; Female; Fetus; Oxid | 2005 |
Physical growth and psychomotor development of infants exposed to antiepileptic drugs in utero.
Topics: Adult; Anticonvulsants; Epilepsy; Female; Growth; Humans; Infant; Maternal Age; Motor Activity; Pari | 2006 |
Variable in vivo embryoprotective role for ataxia-telangiectasia-mutated against constitutive and phenytoin-enhanced oxidative stress in atm knockout mice.
Topics: Animals; Anticonvulsants; Ataxia Telangiectasia Mutated Proteins; Blotting, Western; Cell Cycle Prot | 2006 |
A developmental role for ataxia-telangiectasia mutated in protecting the embryo from spontaneous and phenytoin-enhanced embryopathies in culture.
Topics: Animals; Anticonvulsants; Ataxia Telangiectasia Mutated Proteins; Base Sequence; Cell Cycle Proteins | 2006 |
Cerebral venous sinus thrombosis presenting in the puerperium.
Topics: Adult; Anticoagulants; Female; Heparin; Humans; Magnetic Resonance Angiography; Phenytoin; Postpartu | 2006 |
A comparison study of effects of Echinacea extract and levamisole on phenytoin-induced cleft palate in mice.
Topics: Animals; Biometry; Body Weight; Cleft Palate; Echinacea; Female; Fetus; Levamisole; Male; Maternal E | 2006 |
Use of phenytoin, phenobarbital, or diazepam during pregnancy and risk of congenital abnormalities: a case-time-control study.
Topics: Abnormalities, Drug-Induced; Adult; Anticonvulsants; Case-Control Studies; Cross-Over Studies; Diaze | 2007 |
Increased susceptibility to phenytoin teratogenicity: excessive generation of reactive oxygen species or impaired antioxidant defense?
Topics: Animals; Anti-Arrhythmia Agents; Antioxidants; Embryo, Mammalian; Female; Mice; Mice, Inbred A; Mice | 2006 |
Toxic epidermal necrolysis in a mother and fetus.
Topics: Adolescent; Anticonvulsants; Biopsy; Epilepsy; Female; Fetal Death; Fetus; Humans; Infectious Diseas | 2006 |
Vitamin E supplementation in phenytoin induced developmental toxicity in rats: postnatal study.
Topics: Animals; Animals, Newborn; Dietary Supplements; Female; Fetal Hypoxia; Fetal Viability; Growth and D | 2006 |
Drug treatment during pregnancy and isolated orofacial clefts in hungary.
Topics: Abnormalities, Drug-Induced; Adrenergic beta-Antagonists; Amoxicillin; Anti-Bacterial Agents; Antico | 2007 |
Phenytoin is not successful in preventing cocaine-induced seizures: a response to the article, "Cocaine body packing in pregnancy".
Topics: Anticonvulsants; Cocaine; Crime; Female; Humans; Phenytoin; Pregnancy; Pregnancy Complications; Seiz | 2007 |
Phenytoin but not valproate directly affected in vitro trophoblast differentiation.
Topics: Anticonvulsants; Cell Differentiation; Cells, Cultured; Dose-Response Relationship, Drug; Epilepsy; | 2008 |
Polytherapy with hERG-blocking antiepileptic drugs: increased risk for embryonic cardiac arrhythmia and teratogenicity.
Topics: Animals; Anticonvulsants; Bradycardia; Dimethadione; Dose-Response Relationship, Drug; Drug Therapy, | 2007 |
Preliminary findings from the National Register of Antipsychotic Medication in Pregnancy.
Topics: Adult; Antipsychotic Agents; Australia; Benzodiazepines; Chlorpromazine; Cross-Sectional Studies; Da | 2008 |
Confirmation of the role of N-acetyltransferase 2 in teratogen-induced cleft palate using transgenics and knockouts.
Topics: 6-Aminonicotinamide; Animals; Arylamine N-Acetyltransferase; Base Sequence; Cleft Lip; Cleft Palate; | 2008 |
Contraindications to phenytoin in emergency department patients with seizures.
Topics: Anticonvulsants; Contraindications; Emergency Service, Hospital; Epilepsy; Female; Humans; Levetirac | 2009 |
Delineation of the phenotype associated with 7q36.1q36.2 deletion: long QT syndrome, renal hypoplasia and mental retardation.
Topics: Adult; Anticonvulsants; Base Sequence; Child; Chromosome Deletion; Chromosomes, Human, Pair 7; DNA P | 2008 |
Chronic developmental exposure to phenytoin has long-term behavioral consequences.
Topics: Animals; Animals, Newborn; Anticonvulsants; Appetitive Behavior; Avoidance Learning; Behavior, Anima | 2008 |
Refractory status epilepticus during pregnancy secondary to cavernous angioma.
Topics: Abortion, Induced; Abortion, Therapeutic; Anticonvulsants; Brain Neoplasms; Female; Hemangioma, Cave | 2008 |
Hypomagnesemia with convulsions in a newborn infant. Report of a case associated with maternal hypophosphatemia.
Topics: Calcium; Female; Humans; Hypocalcemia; Hypophosphatemia, Familial; Infant, Newborn; Infant, Newborn, | 1967 |
Anticonvulsant drug therapy in human pregnancy: effects on serum concentrations of vitamin D metabolites in maternal and cord blood.
Topics: 24,25-Dihydroxyvitamin D 3; Adolescent; Adult; Alkaline Phosphatase; Anticonvulsants; Calcifediol; C | 1984 |
Decreased serum protein binding of phenytoin in late pregnancy.
Topics: Blood Proteins; Female; Humans; Phenytoin; Pregnancy; Pregnancy Trimester, Third; Protein Binding | 1980 |
Extrarenal Wilms' tumour in an infant exposed to intrauterine phenytoin.
Topics: Abnormalities, Drug-Induced; Adult; Epilepsy, Absence; Female; Fetus; Genital Neoplasms, Male; Human | 1980 |
Effect of prenatal phenytoin administration on brain tryptophan metabolism of rat offspring during the preweaning period.
Topics: Animals; Animals, Suckling; Brain; Female; Male; Phenytoin; Pregnancy; Rats; Time Factors; Tryptopha | 1980 |
Phenytoin binding in pregnancy.
Topics: Female; Humans; Kinetics; Phenytoin; Pregnancy; Pregnancy Trimester, Third | 1980 |
Phenytoin binding in pregnancy.
Topics: Female; Humans; Infant, Newborn; Phenytoin; Pregnancy; Pregnancy Trimester, Third; Protein Binding | 1981 |
Pharmacokinetics of antiepileptic drugs.
Topics: Adult; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Carbamazepine; Child; Child, Preschool | 1983 |
[Fetal phenytoin syndrome].
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Brain; Developmental Disabilities; Electroence | 1982 |
Susceptibility of mice to phenytoin-induced cleft palate correlated with inhibition of fetal palatal RNA and protein synthesis (41255).
Topics: Animals; Cleft Palate; Female; Fetus; Mice; Mice, Inbred Strains; Palate; Phenytoin; Pregnancy; Prot | 1981 |
Fetal anticonvulsant syndrome in rats: dose- and period-response relationships of prenatal diphenylhydantoin, trimethadione and phenobarbital exposure on the structural and functional development of the offspring.
Topics: Abnormalities, Drug-Induced; Animals; Behavior, Animal; Developmental Disabilities; Dose-Response Re | 1983 |
Impaired phenytoin bioavailability secondary to cisplatinum, vinblastine, and bleomycin.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Biological Availability; Bleomycin; Cisplatin | 1984 |
Ouabain effects on hormonally-stimulated bone resorption and cyclic AMP content in cultured fetal rat bones.
Topics: Animals; Bone Resorption; Calcimycin; Calcitriol; Calcium; Cells, Cultured; Cyclic AMP; Dihydroxycho | 1980 |
Prenatal exposure to electroconvulsive seizures and phenytoin: development of benzodiazepine binding sites, reflex behaviors and seizure thresholds in exposed offspring.
Topics: Animals; Animals, Newborn; Brain; Electroshock; Female; Fetus; gamma-Aminobutyric Acid; Phenytoin; P | 1982 |
Clinical pharmacokinetics of drugs used in the treatment of status epilepticus.
Topics: Animals; Anticonvulsants; Barbiturates; Benzodiazepines; Female; Humans; Kinetics; Models, Biologica | 1983 |
Teratogenic effects of valproic acid and diphenylhydantoin on mouse embryos in culture.
Topics: Animals; Culture Media; Embryo, Mammalian; Female; Mice; Mice, Inbred ICR; Organ Culture Techniques; | 1983 |
Antiepileptic drugs and teratogenesis. How should patients, doctors and health authorities be counselled?
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Carbamazepine; Epilepsy; Female; Humans; Infant, Newbo | 1983 |
Delayed effects of drug exposure during pregnancy: reproductive function.
Topics: Animals; Anticonvulsants; Estrus; Female; Fertility; Luteinizing Hormone; Male; Phenobarbital; Pheny | 1983 |
Serum folate concentrations during pregnancy in women with epilepsy: relation to antiepileptic drug concentrations, number of seizures, and fetal outcome.
Topics: Carbamazepine; Congenital Abnormalities; Epilepsy; Female; Fetal Death; Folic Acid; Humans; Phenobar | 1983 |
A thyroxine-binding protein in human breast milk similar to serum thyroxine-binding globulin.
Topics: Albumins; Anilino Naphthalenesulfonates; Blood Proteins; Female; Humans; Lactose; Milk, Human; Pheny | 1983 |
[Pharmacotherapy of epilepsy--current problems and controversies].
Topics: Adolescent; Adult; Carbamazepine; Child; Child, Preschool; Epilepsies, Partial; Epilepsy; Epilepsy, | 1983 |
Side effects of phenobarbital and phenytoin during long-term treatment of epilepsy.
Topics: Abnormalities, Drug-Induced; Brain; Dose-Response Relationship, Drug; Drug Tolerance; Endocrine Syst | 1983 |
Estimation of free thyroxin with a new thyroxin analog and a porous-glass solid phase.
Topics: Female; Glass; Heparin; Humans; Hyperthyroidism; Hypothyroidism; Male; Methods; Phenytoin; Pregnancy | 1984 |
Enzyme induction in neonates after fetal exposure to antiepileptic drugs.
Topics: Aminopyrine; Aminopyrine N-Demethylase; Anticonvulsants; Breath Tests; Carbamazepine; Carbon Radiois | 1983 |
Congenital liver damage after treatment of mother with valproic acid and phenytoin?
Topics: Adult; Epilepsy, Tonic-Clonic; Female; Humans; Infant; Liver; Liver Diseases; Maternal-Fetal Exchang | 1984 |
Humoral immune dysfunction as a result of prenatal exposure to diphenylhydantoin: correlation with the occurrence of physical defects.
Topics: Abnormalities, Drug-Induced; Animals; Antibodies, Bacterial; Antibody Formation; Bacterial Infection | 1984 |
Teratogenic effects of dosage levels and time of administration of carbamazepine, sodium valproate, and diphenylhydantoin on craniofacial development in the CD-1 mouse fetus.
Topics: Abnormalities, Drug-Induced; Animals; Anticonvulsants; Carbamazepine; Dose-Response Relationship, Dr | 1984 |
Fetal exposure to anticonvulsant drugs. Detailed pathological study of a case.
Topics: Abnormalities, Drug-Induced; Acetazolamide; Adult; Anticonvulsants; Brain; Cardiomegaly; Epilepsy; E | 1980 |
Hand abnormalities in the fetal hydantoin syndrome.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Female; Fingers; Humans; Infant; Infant, Newbo | 1981 |
Lack of behavioural teratogenic effect of phenytoin in rats.
Topics: Acrylamide; Acrylamides; Administration, Oral; Animals; Animals, Newborn; Behavior, Animal; Female; | 1984 |
Fetal hydantoin syndrome and malignancy.
Topics: Brain Neoplasms; Female; Fetal Alcohol Spectrum Disorders; Humans; Hydantoins; Infant, Newborn; Neur | 1984 |
Bioavailability and pharmacokinetics of phenytoin during pregnancy.
Topics: Aging; Biological Availability; Epilepsy; Female; Humans; Kinetics; Phenytoin; Pregnancy; Pregnancy | 1984 |
Comparative in vivo and in vitro studies of phenytoin protein binding and in vitro lipolysis in plasma of pregnant and nonpregnant rats.
Topics: Animals; Anticoagulants; Blood Proteins; Fatty Acids, Nonesterified; Female; In Vitro Techniques; Li | 1984 |
Effect of folic acid on the pharmacokinetics of acutely administered phenytoin in pregnant and nonpregnant rats.
Topics: Animals; Diet; Female; Folic Acid; Kinetics; Phenytoin; Pregnancy; Rats | 1984 |
Functional palatal incompetence in the fetal anticonvulsant syndrome.
Topics: Abnormalities, Drug-Induced; Child, Preschool; Epilepsy; Female; Humans; Male; Maternal-Fetal Exchan | 1984 |
Determination of plasma phenytoin by capillary gas chromatography with nitrogen-phosphorus detection and with selective ion monitoring.
Topics: Adult; Alkylation; Chemical Phenomena; Chemistry; Chromatography, Gas; Epilepsy; Female; Gas Chromat | 1984 |
Splenic hemorrhage in a neonate of a mother on anticonvulsant therapy.
Topics: Female; Hemorrhage; Humans; Infant, Newborn; Male; Phenobarbital; Phenytoin; Pregnancy; Pregnancy Co | 1984 |
Kinetics of drug action in disease states III: Effect of pregnancy on the relationship between phenytoin concentration and antiseizure activity in rats.
Topics: Electroshock; Female; Humans; Kinetics; Pentylenetetrazole; Phenytoin; Pregnancy; Pregnancy Complica | 1984 |
Teratogenicity of anticonvulsant drugs. III: Radiographic hand analysis of children exposed in utero to diphenylhydantoin.
Topics: Epilepsy; Female; Hand; Hand Deformities, Congenital; Humans; Male; Phenytoin; Pregnancy; Pregnancy | 1984 |
Genetic background: the elusive component in the fetal hydantoin syndrome.
Topics: Epilepsy; Female; Hand Deformities, Congenital; Head; Humans; Phenytoin; Pregnancy; Pregnancy Compli | 1984 |
Variable patterns of malformation in the mouse fetal hydantoin syndrome.
Topics: Abnormalities, Multiple; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Female; | 1984 |
[Epilepsy, anticonvulsants and pregnancy].
Topics: Abnormalities, Drug-Induced; Epilepsy; Female; Humans; Phenytoin; Pregnancy; Pregnancy Complications | 1984 |
Effect of folic acid supplementation on congenital malformations due to anticonvulsive drugs.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Drug Therapy, Combination; Epilepsy; Female; Folic Aci | 1984 |
Chromosomal studies of peripheral blood from epileptic patients treated with phenobarbital and/or diphenylhydantoin.
Topics: Adult; Animals; Chromosome Aberrations; Drug Therapy, Combination; Epilepsy; Female; Humans; Male; M | 1984 |
Hodgkin disease in a child with fetal alcohol-hydantoin syndrome.
Topics: Child, Preschool; Ethanol; Female; Fetal Alcohol Spectrum Disorders; Hodgkin Disease; Humans; Phenyt | 1983 |
Effect of phenytoin on maternal heart rate in A/J mice: possible role in teratogenesis.
Topics: Abnormalities, Drug-Induced; Animals; Female; Heart Rate; Mice; Mice, Inbred A; Mice, Inbred C57BL; | 1983 |
Phenytoin therapy for junctional epidermolysis bullosa.
Topics: Adolescent; Epidermolysis Bullosa; Female; Humans; Infant; Infant, Newborn; Phenytoin; Pregnancy | 1983 |
[Relations to the use of antiepileptics by the pregnant woman to the development of congenital abnormalities in her child].
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Epilepsy; Female; Humans; Hydantoins; Infant, Newborn; | 1983 |
Comparative teratogenicity of phenytoin among several inbred strains of mice.
Topics: Abnormalities, Drug-Induced; Animals; Cleft Lip; Cleft Palate; Dose-Response Relationship, Drug; Fem | 1983 |
Effects of diphenylhydantoin on postnatal ontogenesis in the rat. Ultrastructural analysis of Purkinje neurons and hepatocytes.
Topics: Animals; Animals, Newborn; Female; Fetus; Liver; Phenytoin; Pregnancy; Purkinje Cells; Rats; Rats, I | 1983 |
Physiological and environmental determinants of phenytoin teratogenicity: relation to glutathione homeostasis, and potentiation by acetaminophen.
Topics: Acetaminophen; Acetylcysteine; Animals; Cleft Palate; Drug Synergism; Female; Fetal Resorption; Glut | 1983 |
Maternal phenytoin administration affects DNA and protein synthesis in embryonic primary palates.
Topics: Animals; Autoradiography; DNA; Female; Fetal Proteins; Maternal-Fetal Exchange; Mice; Mice, Inbred S | 1983 |
Comparative study on the teratogenicity of some antiepileptics in the rat.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Animals; Anticonvulsants; Carbamazepine; Ethos | 1983 |
The toxicology of chemical interactions during pregnancy in the mouse: caffeine and phenytoin.
Topics: Animals; Caffeine; Drug Interactions; Female; Fetal Death; Fetal Resorption; Mice; Mice, Inbred ICR; | 1984 |
Tissue assay of phenobarbital, phenytoin and p-hydroxyphenytoin by high-performance liquid chromatography.
Topics: Animals; Brain; Chemical Phenomena; Chemistry; Chromatography, High Pressure Liquid; Female; Fetus; | 1984 |
Effect of pregnancy on the pharmacokinetics of phenytoin in rats.
Topics: Animals; Dose-Response Relationship, Drug; Female; Half-Life; Kinetics; Metabolic Clearance Rate; Ph | 1984 |
[Genetic causes for the variability of effects and side effects of drugs].
Topics: Debrisoquin; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Hydroxylation; Kinetic | 1982 |
Teratogenic effects of anticonvulsants.
Topics: Abnormalities, Drug-Induced; Animals; Anticonvulsants; Carbamazepine; Cleft Palate; Eyelid Diseases; | 1981 |
Ocular manifestations of the fetal hydantoin syndrome.
Topics: Coloboma; Eye; Eye Abnormalities; Female; Fetal Diseases; Humans; Infant; Microphthalmos; Phenytoin; | 1981 |
Drug treatment of epilepsy.
Topics: Anticonvulsants; Carbamazepine; Clonazepam; Electroencephalography; Epilepsy; Ethosuximide; Female; | 1981 |
Altered drug binding to serum proteins in pregnant women: therapeutic relevance.
Topics: Adult; Blood Proteins; Diazepam; Female; Humans; In Vitro Techniques; Phenytoin; Pregnancy; Pregnanc | 1981 |
Recent advances in the treatment of epilepsy.
Topics: Anticonvulsants; Carbamazepine; Drug Interactions; Drug Therapy, Combination; Epilepsy; Female; Huma | 1980 |
Placental transfer of anticonvulsants (phenobarbital, phenytoin, valproic acid) and the elimination from neonates.
Topics: Anticonvulsants; Bilirubin; Female; Fetal Blood; Half-Life; Humans; Infant, Newborn; Male; Maternal- | 1981 |
Brain maturation following administration of phenobarbital, phenytoin, and sodium valproate to developing rats or to their dams: effects on synthesis of brain myelin and other subcellular membrane proteins.
Topics: Animals; Anticonvulsants; Brain; Female; Intracellular Membranes; Membrane Proteins; Myelin Proteins | 1982 |
Five kits for estimating free thyroxin concentration in serum evaluated, and correlated with other indices to thyroid status.
Topics: Adolescent; Adult; Aged; Contraceptives, Oral; Female; Humans; Male; Middle Aged; Phenytoin; Pregnan | 1982 |
Antipyrine disposition in relation to lowered anticonvulsant plasma level during pregnancy.
Topics: Adult; Anticonvulsants; Antipyrine; Delivery, Obstetric; Dose-Response Relationship, Drug; Epilepsy; | 1982 |
The interaction of chemicals during pregnancy: an update.
Topics: Abnormalities, Drug-Induced; Animals; Bromodeoxyuridine; Caffeine; Drug Interactions; Female; Fetus; | 1983 |
Susceptibility to phenytoin-induced cleft palate in mice is influenced by genes linked to H-2 and H-3.
Topics: Abnormalities, Drug-Induced; Animals; Cleft Palate; Female; Fetal Resorption; Genotype; H-2 Antigens | 1983 |
Behavioral outcome after prenatal exposure to phenytoin in rats.
Topics: Aging; Animals; Behavior, Animal; Body Weight; Female; Learning; Motor Activity; Phenytoin; Pregnanc | 1983 |
Phenytoin in pregnancy: a review of the reported risks.
Topics: Abnormalities, Drug-Induced; Blood Coagulation Disorders; Epilepsy; Female; Humans; Infant; Infant, | 1983 |
Alcohol, other drugs and the fetus.
Topics: Abnormalities, Drug-Induced; Carbamazepine; Dextropropoxyphene; Diazepam; Drug Synergism; Female; Fe | 1982 |
Carbamazepine. Pharmacology and clinical uses.
Topics: Adult; Alcohol Withdrawal Delirium; Arrhythmias, Cardiac; Behavior; Carbamazepine; Child; Diabetes I | 1981 |
Sixteen types of epidermolysis bullosa. On the clinical discrimination, therapy and prenatal diagnosis.
Topics: Adrenal Cortex Hormones; Adult; Blister; Child, Preschool; Epidermolysis Bullosa; Female; Hot Temper | 1981 |
Severe cardiac and ophthalmologic malformations in an infant exposed to diphenylhydantoin in utero.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adult; Eye Diseases; Female; Heart Defects, Co | 1982 |
Serum protein binding and free concentration of phenytoin and phenobarbitone in pregnancy.
Topics: Adult; Blood Proteins; Female; Humans; Phenobarbital; Phenytoin; Pregnancy; Pregnancy Trimester, Fir | 1982 |
Combined fetal alcohol and hydantoin syndromes.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adult; Alcoholism; Epilepsy; Female; Fetal Alc | 1982 |
Maternal anticonvulsant therapy and hemorrhagic disease of the newborn.
Topics: Adult; Female; Humans; Infant, Newborn; Phenobarbital; Phenytoin; Pregnancy; Pregnancy Complications | 1982 |
Changes in plasma protein binding of drugs after blood collection from pregnant rats.
Topics: Animals; Blood Proteins; Blood Specimen Collection; Female; Pharmaceutical Preparations; Phenytoin; | 1982 |
Mouse fetal hydantoin syndrome: effects of maternal seizures.
Topics: Abnormalities, Drug-Induced; Animals; Congenital Abnormalities; Female; Maternal-Fetal Exchange; Mic | 1982 |
Effect of phenytoin on calcium disposition in pregnant and nonpregnant mice.
Topics: Animals; Biological Transport; Bone and Bones; Calcium; Female; Fetus; Male; Maternal-Fetal Exchange | 1982 |
Phenytoin and lactation.
Topics: Adult; Female; Humans; Lactation; Phenytoin; Pregnancy | 1982 |
Subcutaneous vascular abnormalities in fetal hydantoin syndrome.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Blood Vessels; Child, Preschool; Female; Human | 1982 |
Drug disposition during pregnancy.
Topics: Anti-Bacterial Agents; Clorazepate Dipotassium; Diazepam; Digoxin; Female; Furosemide; Humans; Kidne | 1982 |
Occurrence of cleft palate, micrognathia, and agnathia in selected strains of cortisone- and phenytoin-treated mice.
Topics: Animals; Cleft Palate; Cortisone; Female; Genes; H-2 Antigens; Jaw Abnormalities; Male; Mandible; Mi | 1982 |
[Effect of buformin and diphenylhydantoin on the life span, estrous function and spontaneous tumor incidence in rats].
Topics: Animals; Biguanides; Body Weight; Buformin; Estrus; Female; Longevity; Neoplasms, Experimental; Phen | 1980 |
Plasma levels and clinical effects of antiepileptic drugs in pregnant epileptic patients and their newborns.
Topics: Adult; Anticonvulsants; Clonazepam; Epilepsy; Female; Humans; Infant, Newborn; Phenobarbital; Phenyt | 1980 |
Episodic complete airway obstruction in infants.
Topics: Airway Obstruction; Drug Therapy, Combination; Female; Humans; Infant; Infant, Newborn; Infant, Newb | 1981 |
[Pharmacological studies on the functional development of the central nervous system in first generation rats born to phenytoin-treated mothers (author's transl)].
Topics: Animals; Animals, Newborn; Ataxia; Birth Rate; Brain; Catalepsy; Diazepam; Eye; Feeding Behavior; Fe | 1982 |
The effects of phenytoin on rat development: an animal model system for fetal hydantoin syndrome.
Topics: Abnormalities, Drug-Induced; Animals; Disease Models, Animal; Female; Growth Disorders; Humans; Inte | 1981 |
Anterior spinal artery syndrome during the postpartum period.
Topics: Adult; Cerebral Hemorrhage; Epilepsy; Female; Humans; Infant, Newborn; Male; Maternal-Fetal Exchange | 1981 |
The teratological problem of antiepileptic drugs.
Topics: Abnormalities, Drug-Induced; Adult; Animals; Anticonvulsants; Chromosome Aberrations; Cleft Lip; Cle | 1980 |
Critical periods for diphenylhydantoin and phenobarbital administration during gestation.
Topics: Animals; Avoidance Learning; Critical Period, Psychological; Female; Gestational Age; Phenobarbital; | 1980 |
Cardiovascular and hematologic effects of diphenylhydantoin in maternal and fetal sheep.
Topics: Acid-Base Equilibrium; Alkalosis; Animals; Blood Pressure; Cardiovascular System; Epilepsy; Female; | 1981 |
Comparative teratogenicity of cortisone and phenytoin in mice.
Topics: Animals; Body Weight; Cleft Palate; Cortisone; Dose-Response Relationship, Drug; Female; Fetal Resor | 1981 |
Phenytoin administration to pregnant mice: a mutagenic action?
Topics: Abnormalities, Drug-Induced; Animals; Female; Fertility; Fetal Resorption; Mice; Mutagens; Phenytoin | 1981 |
Effects of phenytoin on [3H]diazepam binding in dissociated primary cortical cell culture.
Topics: Animals; Benzodiazepinones; Binding Sites; Cells, Cultured; Cerebral Cortex; Diazepam; Female; Gluta | 1981 |
Anticonvulsants and pregnancy.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Epilepsy; Female; Humans; Infant, Newborn; Maternal-Fe | 1981 |
Perioperative anesthetic management of a patient with long Q-T syndrome (LQTS).
Topics: Adult; Anesthesia; Arrhythmias, Cardiac; Electrocardiography; Female; Heart Ventricles; Humans; Lido | 1981 |
Fetal hydantoin syndrome.
Topics: Abnormalities, Drug-Induced; Child; Female; Fingers; Humans; Maternal-Fetal Exchange; Nail Diseases; | 1981 |
Fatal hydantoin syndrome: congenital malformation of the urinary tract-a case report.
Topics: Abnormalities, Drug-Induced; Female; Humans; Infant, Newborn; Male; Phenytoin; Pregnancy; Urinary Tr | 1981 |
Effect of anticonvulsants on in vitro prothrombin synthesis in adult and fetal rat liver.
Topics: Aging; Animals; Anticonvulsants; Female; In Vitro Techniques; Liver; Male; Phenobarbital; Phenytoin; | 1981 |
Protein-bound and free plasma phenytoin during pregnancy.
Topics: Blood Proteins; Epilepsy; Female; Fetus; Humans; Ovulation Induction; Phenytoin; Pregnancy; Pregnanc | 1981 |
Effect of prenatal phenytoin administration on postnatal development of the rat: a behavioral teratology study.
Topics: Animals; Behavior, Animal; Brain; DNA; Female; Locomotion; Organ Size; Orientation; Phenytoin; Pregn | 1981 |
Association of hemorrhagic disease and the syndrome of persistent fetal circulation with the fetal hydantoin syndrome.
Topics: Adult; Female; Hemorrhage; Humans; Infant, Newborn; Male; Partial Thromboplastin Time; Persistent Fe | 1980 |
From the NIH: Some side effects of phenytoin are studied.
Topics: Adult; Animals; Blood; Child; Epilepsy; Female; Fetus; Gingiva; Gingival Hypertrophy; Humans; Matern | 1980 |
Nonvariance of LD50 values of drugs in gravid and nongravid mice.
Topics: Animals; Cobalt; Female; Lethal Dose 50; Male; Mice; Morphine; Phenytoin; Pregnancy; Pregnancy, Anim | 1980 |
Diphenylhydantoin: pre- and postnatal administration alters diazepam binding in developing rat cerebral cortex.
Topics: Animals; Benzodiazepines; Cerebral Cortex; Diazepam; Female; Fetus; Maternal-Fetal Exchange; Phenyto | 1980 |
Serum protein binding of drugs and bilirubin in newborn infants and their mothers.
Topics: Bilirubin; Blood Proteins; Diazepam; Female; Fetal Blood; Humans; Individuality; Infant, Newborn; Ox | 1980 |
Serum protein binding of drugs during and after pregnancy in humans.
Topics: Adolescent; Adult; Blood Proteins; Contraceptives, Oral; Dexamethasone; Diazepam; Dose-Response Rela | 1980 |
The ingestion by pregnant women of substances toxic to the foetus.
Topics: Abnormalities, Drug-Induced; Barbiturates; Clitoris; Diazepam; Disorders of Sex Development; Doxylam | 1980 |
Phenytoin therapy and hemorrhagic disease.
Topics: Adolescent; Adult; Child; Female; Humans; Infant, Newborn; Male; Maternal-Fetal Exchange; Phenytoin; | 1980 |
Fetal hydantoin syndrome, neuroblastoma, and hemorrhagic disease in a neonate.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Epilepsy; Female; Humans; Hydantoins; Infant, | 1980 |
Antiepileptic drugs, the developing nervous system, and the pregnant woman with epilepsy.
Topics: Abnormalities, Drug-Induced; Central Nervous System; Epilepsy; Female; Fetus; Humans; Infant, Newbor | 1980 |
The influence of phenytoin on the ontogenesis of hepatic monooxygenases in the perinatal guinea pig.
Topics: Animals; Animals, Newborn; Female; Guinea Pigs; Liver; Maternal-Fetal Exchange; Microsomes, Liver; M | 1980 |
[Intensive care of severe preeclampsia-eclampsia. A report on 22 cases (author's transl)].
Topics: Acute Kidney Injury; Adolescent; Adult; Brain Edema; Critical Care; Diazepam; Dihydralazine; Eclamps | 1980 |
Phenytoin metabolism in pregnancy.
Topics: Adult; Epilepsy; Female; Fetal Blood; Humans; Kinetics; Phenytoin; Pregnancy; Pregnancy Complication | 1980 |
[Hydantoin syndrome in a neonate].
Topics: Abnormalities, Drug-Induced; Female; Humans; Hypospadias; Infant, Newborn; Male; Nails, Malformed; P | 1980 |
Teratogenicity of diphenylhydantoin in the New Zealand white rabbit.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Animals; Dose-Response Relationship, Drug; Fem | 1980 |
Magnesium sulfate versus phenytoin for the prevention of eclampsia.
Topics: Anticonvulsants; Eclampsia; Electroencephalography; Female; Humans; Magnesium Sulfate; Phenytoin; Pr | 1995 |
Magnesium sulfate versus phenytoin for the prevention of eclampsia.
Topics: Anticonvulsants; Eclampsia; Electroencephalography; Female; Humans; Magnesium Sulfate; Phenytoin; Pr | 1995 |
Magnesium sulfate versus phenytoin for the prevention of eclampsia.
Topics: Anticonvulsants; Double-Blind Method; Eclampsia; Female; Humans; Magnesium Sulfate; Phenytoin; Pregn | 1995 |
Neurodevelopment of children exposed in utero to phenytoin and carbamazepine monotherapy.
Topics: Carbamazepine; Case-Control Studies; Child; Cognition; Developmental Disabilities; Female; Humans; I | 1994 |
Neurodevelopment after in utero exposure to phenytoin and carbamazepine.
Topics: Carbamazepine; Child; Developmental Disabilities; Female; Humans; Phenytoin; Pregnancy; Prenatal Exp | 1994 |
Neurodevelopment after in utero exposure to phenytoin and carbamazepine.
Topics: Carbamazepine; Child; Developmental Disabilities; Female; Humans; Phenytoin; Pregnancy; Prenatal Exp | 1994 |
Red cell folate levels in pregnant epileptic women.
Topics: Adult; Carbamazepine; Epilepsy; Erythrocytes; Female; Folic Acid; Follow-Up Studies; Humans; Phenyto | 1995 |
Phenytoin-initiated DNA oxidation in murine embryo culture, and embryo protection by the antioxidative enzymes superoxide dismutase and catalase: evidence for reactive oxygen species-mediated DNA oxidation in the molecular mechanism of phenytoin teratogen
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Catalase; Culture Media; Culture Techniques; Deoxyguanosine; D | 1995 |
Metabolism of carbamazepine and co-administered anticonvulsants during pregnancy.
Topics: Adult; Anticonvulsants; Carbamazepine; Drug Therapy, Combination; Epilepsy; Female; Humans; Phenytoi | 1995 |
Anticonvulsant teratogenesis: 3. Possible metabolic basis.
Topics: Abnormalities, Drug-Induced; Amnion; Cells, Cultured; Epoxide Hydrolases; Female; Fibroblasts; Human | 1995 |
Potential molecular targets mediating chemical teratogenesis: in vitro peroxidase-catalyzed phenytoin metabolism and oxidative damage to proteins and lipids in murine maternal hepatic microsomes and embryonic 9000g supernatant.
Topics: Animals; Biotransformation; Embryo, Mammalian; Female; In Vitro Techniques; Lipid Peroxidation; Mice | 1995 |
Vinpocetine is a highly potent neuroprotectant against veratridine-induced cell death in primary cultures of rat cerebral cortex.
Topics: Animals; Anticonvulsants; Cell Death; Cells, Cultured; Cerebral Cortex; Dose-Response Relationship, | 1995 |
Human umbilical vessels: responses to agents frequently used in obstetric patients.
Topics: Analysis of Variance; Calcium Channel Blockers; Dihydropyridines; Female; Humans; Hydralazine; In Vi | 1995 |
Neuroprotective effect of phenytoin against in utero hypoxic brain injury in fetal guinea pigs.
Topics: Animals; Cell Membrane; Chromatography, High Pressure Liquid; Female; Fetal Hypoxia; Guinea Pigs; Hy | 1995 |
Magnesium for preeclampsia and eclampsia.
Topics: Eclampsia; Female; Humans; Magnesium Sulfate; Phenytoin; Pre-Eclampsia; Pregnancy | 1995 |
Bradycardia as a presenting feature of late postpartum eclampsia.
Topics: Adult; Bradycardia; Drug Therapy, Combination; Eclampsia; Female; Humans; Magnesium Sulfate; Nifedip | 1994 |
Phenytoin prophylaxis in severe pre-eclampsia and eclampsia.
Topics: Eclampsia; Female; Humans; Magnesium Sulfate; Phenytoin; Pre-Eclampsia; Pregnancy | 1995 |
Cocaine-sensitive sigma-receptor and its interaction with steroid hormones in the human placental syncytiotrophoblast and in choriocarcinoma cells.
Topics: Choriocarcinoma; Cocaine; Female; Giant Cells; Gonadal Steroid Hormones; Haloperidol; Humans; Ligand | 1995 |
n-3 fatty acids inhibit defects and fatty acid changes caused by phenytoin in early gestation in mice.
Topics: Abnormalities, Drug-Induced; Animal Feed; Animals; Body Weight; Fatty Acids, Omega-3; Fatty Acids, U | 1994 |
Evidence for lipoxygenase-catalyzed bioactivation of phenytoin to a teratogenic reactive intermediate: in vitro studies using linoleic acid-dependent soybean lipoxygenase, and in vivo studies using pregnant CD-1 mice.
Topics: 5,8,11,14-Eicosatetraynoic Acid; Abnormalities, Drug-Induced; Animals; Biotransformation; Catalysis; | 1995 |
Basilar invagination and mid-line skeletal abnormalities due to in utero exposure to phenytoin.
Topics: Adult; Arnold-Chiari Malformation; Bone Transplantation; Cleft Lip; Cleft Palate; Diseases in Twins; | 1994 |
Holoprosencephaly and the teratogenicity of anticonvulsants.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Anticonvulsants; Epilepsy; Face; Female; Finge | 1994 |
Pregnancy, epilepsy, management and outcome: a 10-year perspective.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Birth Weight; Carbamazepine; Cohort Studies; Drug Ther | 1993 |
In vivo phenytoin-initiated oxidative damage to proteins and lipids in murine maternal hepatic and embryonic tissue organelles: potential molecular targets of chemical teratogenesis.
Topics: Animals; Embryo, Mammalian; Female; Lipid Metabolism; Lipid Peroxidation; Liver; Mice; Mice, Inbred | 1994 |
Phenytoin prophylaxis in severe pre-eclampsia and eclampsia.
Topics: Eclampsia; Female; Humans; Magnesium Sulfate; Phenytoin; Pre-Eclampsia; Pregnancy; Randomized Contro | 1994 |
Prenatal prediction of risk of the fetal hydantoin syndrome.
Topics: Abnormalities, Drug-Induced; Biomarkers; Chorionic Villi; Epoxide Hydrolases; Female; Fetal Diseases | 1993 |
Phenytoin and magnesium sulfate effects on fetal heart rate tracings assessed by computer analysis.
Topics: Diagnosis, Computer-Assisted; Female; Heart Rate, Fetal; Humans; Magnesium Sulfate; Phenytoin; Pre-E | 1993 |
Phenytoin prophylaxis in severe pre-eclampsia and eclampsia.
Topics: Adult; Dose-Response Relationship, Drug; Eclampsia; Female; Humans; Phenytoin; Pre-Eclampsia; Pregna | 1993 |
Comparative carcinogenicity of 5,5-diphenylhydantoin with or without perinatal exposure in rats and mice.
Topics: Adenoma, Liver Cell; Animals; Body Weight; Carcinogens; Carcinoma, Hepatocellular; Female; Fetal Dea | 1993 |
DNA oxidation as a potential molecular mechanism mediating drug-induced birth defects: phenytoin and structurally related teratogens initiate the formation of 8-hydroxy-2'-deoxyguanosine in vitro and in vivo in murine maternal hepatic and embryonic tissue
Topics: 8-Hydroxy-2'-Deoxyguanosine; Abnormalities, Drug-Induced; Alkaline Phosphatase; Animals; Biotransfor | 1995 |
Phenytoin serum concentration monitoring during pregnancy and puerperium in Mexican epileptic women.
Topics: Adolescent; Adult; Epilepsy; Female; Humans; Male; Phenytoin; Postpartum Period; Pregnancy; Pregnanc | 1995 |
Infant monkey hyperexcitability after prenatal exposure to antiepileptic compounds.
Topics: Animals; Animals, Newborn; Anticonvulsants; Behavior, Animal; Carbamazepine; Dioxolanes; Disease Mod | 1996 |
Phenytoin embryopathy: effect of epoxide hydrolase inhibitor on phenytoin exposure in utero in C57BL/6J mice.
Topics: Animals; Anticonvulsants; Body Weight; Drug Interactions; Enzyme Inhibitors; Epoxide Hydrolases; Fem | 1995 |
Phenytoin causes phalangeal hypoplasia in the rabbit fetus at clinically relevant free plasma concentrations.
Topics: Abnormalities, Drug-Induced; Administration, Oral; Analysis of Variance; Animals; Anticonvulsants; E | 1995 |
Pre-eclampsia and maternal mortality.
Topics: Anticonvulsants; Diazepam; England; Female; Humans; Magnesium Sulfate; Maternal Mortality; Phenytoin | 1996 |
Evidence for embryonic prostaglandin H synthase-catalyzed bioactivation and reactive oxygen species-mediated oxidation of cellular macromolecules in phenytoin and benzo[a]pyrene teratogenesis.
Topics: Animals; Benzo(a)pyrene; Biotransformation; Cattle; Culture Techniques; DNA Damage; Embryo, Mammalia | 1997 |
Phenytoin monitoring in pregnancy and puerperium.
Topics: Epilepsy; Female; Humans; Phenytoin; Pregnancy; Pregnancy Complications; Puerperal Disorders | 1997 |
Phenytoin-mediated oxidative stress in serum of female epileptics: a possible pathogenesis in the fetal hydantoin syndrome.
Topics: Analysis of Variance; Anticonvulsants; Copper; Epilepsy; Female; Glutathione; Humans; Lipid Peroxida | 1997 |
Phenytoin-induced teratogenesis: a molecular basis for the observed developmental delay during neurulation.
Topics: Abnormalities, Drug-Induced; Animals; Cadherins; Cell Cycle Proteins; Central Nervous System; Collag | 1997 |
Comparative study of different anticonvulsants in eclampsia.
Topics: Adult; Anticonvulsants; Chlorpromazine; Diazepam; Eclampsia; Female; Humans; Magnesium Sulfate; Mepe | 1997 |
[Pharmacokinetic variations in anticonvulsants in Mexican epileptic women during different stages of the postpartum period].
Topics: Animals; Anticonvulsants; Carbamazepine; Cricetinae; Epilepsy; Female; Humans; Milk, Human; Phenytoi | 1997 |
Phenytoin transfer across the in situ perfused rat term placenta.
Topics: Analgesics; Animals; Anticonvulsants; Antipyrine; Blood Proteins; Chemical Phenomena; Chemistry, Phy | 1997 |
Initiation of phenytoin teratogenesis: pharmacologically induced embryonic bradycardia and arrhythmia resulting in hypoxia and possible free radical damage at reoxygenation.
Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Bradycardia; Cell Culture Techniques; Dose-Re | 1997 |
The case of the dire desquamation. Stevens-Johnson syndrome.
Topics: Aged; Anticonvulsants; Brain Neoplasms; Breast Neoplasms; Cranial Irradiation; Fatal Outcome; Female | 1998 |
Clustered binary logistic regression in teratology data using a finite mixture distribution.
Topics: Animals; Anticonvulsants; Bone Development; Cluster Analysis; Computer Simulation; Drug Synergism; E | 1997 |
Fetal hydantoin syndrome: an unusual cause of hip dysplasia.
Topics: Abnormalities, Drug-Induced; Acetabulum; Adult; Anticonvulsants; Epilepsy; Female; Hip Dislocation, | 1998 |
Use of anticonvulsants in eclampsia and pre-eclampsia: survey of obstetricians in the United Kingdom and Republic of Ireland.
Topics: Anticonvulsants; Chlormethiazole; Diazepam; Eclampsia; Female; Humans; Ireland; Magnesium Sulfate; O | 1998 |
Pharmacologically induced embryonic dysrhythmia and episodes of hypoxia followed by reoxygenation: a common teratogenic mechanism for antiepileptic drugs?
Topics: Abnormalities, Drug-Induced; Animals; Anti-Arrhythmia Agents; Anticonvulsants; Arrhythmias, Cardiac; | 1998 |
Maternal hypertension and neurodevelopmental outcome in very preterm infants.
Topics: Adult; Anticonvulsants; Antihypertensive Agents; Case-Control Studies; Cerebral Palsy; Child, Presch | 1998 |
Maternal administration of superoxide dismutase and catalase in phenytoin teratogenicity.
Topics: Abnormalities, Drug-Induced; Analysis of Variance; Animals; Anticonvulsants; Catalase; Female; Mater | 1999 |
Phenytoin-induced alterations in craniofacial gene expression.
Topics: Abnormalities, Drug-Induced; Animals; Anticonvulsants; DNA, Complementary; Embryonic and Fetal Devel | 1999 |
Prenatal exposure to anticonvulsants and psychosexual development.
Topics: Anticonvulsants; Cross-Sectional Studies; Female; Follow-Up Studies; Gender Identity; Humans; Male; | 1999 |
Atrioventricular septal defect with separate right and left atrioventricular valvar orifices in a patient with foetal hydantoin syndrome.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Cardiac Catheterization; Echocardiography, Doppler; Ep | 1999 |
Magnesium sulphate for eclamptic seizures?
Topics: Anticonvulsants; Contraindications; Eclampsia; Electroencephalography; Female; Humans; Magnesium Sul | 1999 |
Malformations in offspring of women with epilepsy: a prospective study.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Carbamazepine; Comorbidity; Congenital Abnormalities; | 1999 |
Magnesium sulphate for eclamptic seizure.
Topics: Anticonvulsants; Eclampsia; Female; Humans; Magnesium Sulfate; Phenytoin; Pregnancy; Seizures | 1999 |
Blepharoptosis and central nervous system abnormalities in combined valproate and hydantoin embryopathy.
Topics: Abnormalities, Drug-Induced; Adult; Anticonvulsants; Blepharoptosis; Brain; Drug Therapy, Combinatio | 2000 |
Pharmacokinetic data support pharmacologically induced embryonic dysrhythmia as explanation to Fetal Hydantoin Syndrome in rats.
Topics: Abnormalities, Drug-Induced; Animals; Arrhythmias, Cardiac; Culture Techniques; Dose-Response Relati | 2000 |
Temporal and spatial expression of Hoxa-2 during murine palatogenesis.
Topics: Amino Acid Sequence; Animals; Antibody Specificity; Anticonvulsants; Blotting, Northern; Blotting, W | 2000 |
Eclampsia: a 13-year experience at a United States tertiary care center.
Topics: Adult; Anticonvulsants; Antihypertensive Agents; Boston; Eclampsia; Female; Hospitals, Maternity; Hu | 1999 |
Association of prenatal phenobarbital and phenytoin exposure with small head size at birth and with learning problems.
Topics: Adult; Anticonvulsants; Cephalometry; Cognition; Cross-Sectional Studies; Epilepsy; Female; Follow-U | 2000 |
Gender self-reassignment in an XY adolescent female born with ambiguous genitalia.
Topics: Disorders of Sex Development; Female; Gender Identity; Humans; Male; Nails, Malformed; Penis; Phenyt | 2000 |
A clinical study of 57 children with fetal anticonvulsant syndromes.
Topics: Abnormalities, Drug-Induced; Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Ep | 2000 |
Evidence-based implementation of free phenytoin therapeutic drug monitoring.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Blood Proteins; Child; Evidence-Based Medicine; Female; Hu | 2000 |
Antioxidant and GSH-related enzyme response to a single teratogenic exposure to the anticonvulsant phenytoin: temporospatial evaluation.
Topics: Abortion, Veterinary; Animals; Anticonvulsants; Antioxidants; Catalase; Cleft Palate; Cytosol; Down- | 2000 |
Comparison of in vitro and in vivo developmental toxicity and pharmacokinetics of phenytoin in the rat.
Topics: Abnormalities, Drug-Induced; Administration, Oral; Analysis of Variance; Animals; Anticonvulsants; C | 2000 |
Phenytoin-induced cleft palate: evidence for embryonic cardiac bradyarrhythmia due to inhibition of delayed rectifier K+ channels resulting in hypoxia-reoxygenation damage.
Topics: Abnormalities, Drug-Induced; Animals; Anticonvulsants; Bradycardia; Cleft Palate; Delayed Rectifier | 2001 |
The teratogenicity of anticonvulsant drugs.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Carbamazepine; Case-Control Studies; Congenital Abnorm | 2001 |
Association of prenatal phenobarbital and phenytoin exposure with genital anomalies and menstrual disorders.
Topics: Adult; Anticonvulsants; Case-Control Studies; Cryptorchidism; Female; Follow-Up Studies; Genitalia; | 2001 |
Pregnant women received drug without consent, hospital says.
Topics: Cesarean Section; Chicago; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hospital | 1988 |
Cutaneous drug reaction case reports: from the world literature.
Topics: Adult; Adverse Drug Reaction Reporting Systems; Aged; Bupropion; Celecoxib; Chlorquinaldol; Cytarabi | 2002 |
Embryonic arrhythmia by inhibition of HERG channels: a common hypoxia-related teratogenic mechanism for antiepileptic drugs?
Topics: Abnormalities, Drug-Induced; Age Factors; Animals; Anticonvulsants; Arrhythmias, Cardiac; Cation Tra | 2002 |
Psychomotor development in preschool children exposed to antiepileptic drugs in utero.
Topics: Anticonvulsants; Child, Preschool; Female; Humans; Longitudinal Studies; Male; Maternal-Fetal Exchan | 2002 |
The effect of microsomal enzyme inducing drugs on reproductive function in the ewe.
Topics: Animals; Corpus Luteum; Enzyme Induction; Estrus; Female; Liver; Luteinizing Hormone; Microsomes, Li | 1975 |
IARC monographs on the evaluation of the carcinogenic risk of chemicals to man: some miscellaneous pharmaceutical substances.
Topics: Acriflavine; Animals; Anthralin; Aurothioglucose; Carcinogens; Chloroquine; Diazepam; Ethanolamines; | 1977 |
An improved method for preparation of samples for the simultaneous assay of some antiepileptic drugs by gas-liquid chromatography.
Topics: Barbiturates; Body Fluids; Chromatography, Gas; Female; Humans; Milk, Human; Phenobarbital; Phenytoi | 1978 |
Anticonvulsants and parental epilepsy in the development of birth defects.
Topics: Abnormalities, Drug-Induced; Congenital Abnormalities; Epilepsy; Female; Finland; Follow-Up Studies; | 1976 |
Letter: Diazepam, phenytoin, and aetiology of cleft lip and/or cleft palate.
Topics: Anencephaly; Cleft Lip; Cleft Palate; Diazepam; Female; Humans; Infant, Newborn; Phenytoin; Pregnanc | 1976 |
Letter: Anticonvulsants and fetal malformations.
Topics: Abnormalities, Drug-Induced; Epilepsy; Female; Humans; Infant, Newborn; Phenobarbital; Phenytoin; Pr | 1976 |
VACTERL congenital malformation and phenytoin therapy.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adolescent; Epilepsy; Female; Humans; Infant, | 1976 |
Fetal hydantoin syndrome and neuroblastoma.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adrenal Gland Neoplasms; Child, Preschool; Fem | 1976 |
The medical treatment of epilepsy: antiepileptic drug interactions and teratogenicity.
Topics: Abnormalities, Drug-Induced; Adult; Anticonvulsants; Calcium; Carbamazepine; Child; Dicumarol; Digit | 1979 |
[Drug resistance in epilepsy therapy].
Topics: Anticonvulsants; Contraceptives, Oral; Drug Resistance; Drug Therapy, Combination; Electroencephalog | 1978 |
Fetal heart rate during a maternal grand mal epileptic seizure.
Topics: Adult; Epilepsy, Tonic-Clonic; Female; Fetal Heart; Fetal Hypoxia; Fetal Monitoring; Heart Rate; Hum | 1979 |
[Effect of diphenylhydantoin administered during gestation and lactation on the motor development and cerebellar histology of the young rat].
Topics: Animals; Animals, Suckling; Cerebellum; Female; Maternal-Fetal Exchange; Motor Skills; Phenytoin; Pr | 1978 |
The effect of various drugs on maternal serum cystine aminopeptidase.
Topics: Adolescent; Adult; Aminopeptidases; Cystinyl Aminopeptidase; Diazepam; Female; Humans; In Vitro Tech | 1977 |
Teratological effects of diphenylhydantoin (DPH) in A/J mice.
Topics: Abnormalities, Drug-Induced; Animals; Female; Fetal Resorption; Mice; Mice, Inbred Strains; Phenytoi | 1979 |
[Drug therapy of epilepsy].
Topics: Age Factors; Anticonvulsants; Barbiturates; Benzodiazepines; Bromides; Carbamazepine; Chlormethiazol | 1977 |
Long-term use of the major anticonvulsant drugs.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Carbamazepine; Drug Interactions; Epilepsy; Ethosuximi | 1978 |
Abnormal genitalia as a presenting sign in two male infants with hydantoin embryopathy syndrome.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adolescent; Adult; Epilepsy, Tonic-Clonic; Fem | 1977 |
[Anticonvulsants and simultaneous medication - a problem in pregnancy (author's transl)].
Topics: Adult; Anticonvulsants; Antiemetics; Dihydroergotamine; Drug Combinations; Drug Interactions; Drug T | 1977 |
Effects of chronic administration of diphenylhydantoin on learning and offspring behavior.
Topics: Animals; Avoidance Learning; Behavior, Animal; Female; Male; Maternal-Fetal Exchange; Phenytoin; Pre | 1977 |
[Increase of the teratogenic power of diphenylhydantoin by phenobarbital in mice].
Topics: Animals; Drug Synergism; Female; Fetus; Mice; Phenobarbital; Phenytoin; Pregnancy; Teratogens | 1977 |
One-sided gingival hyperplasia after treatment with diphenylhydantoin.
Topics: Adult; Epilepsies, Partial; Female; Gingival Hyperplasia; Humans; Phenytoin; Pregnancy; Pregnancy Co | 1977 |
Maternal anticonvulsants and optic nerve hypoplasia.
Topics: Abnormalities, Drug-Induced; Child; Child, Preschool; Epilepsy, Tonic-Clonic; Female; Humans; Infant | 1978 |
Medical treatment of epilepsy: Part II.
Topics: Abnormalities, Drug-Induced; Adult; Anticonvulsants; Calcium; Child; Drug Interactions; Epilepsy; Ep | 1978 |
Anticonvulsant therapy. Approaches to some common clinical problems.
Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Anticonvulsants; Carbamazepine; Child; Epilepsy; Eth | 1979 |
Epilepsy among parents of children with facial clefts.
Topics: Anticonvulsants; Cleft Lip; Cleft Palate; Epilepsy; Female; Humans; Male; Parents; Phenobarbital; Ph | 1979 |
[Significance of pharmacogenic liver reactions for metabolism of endogenous and exogenous substances].
Topics: Carbamazepine; Diazepam; Drug-Related Side Effects and Adverse Reactions; Female; Fenoterol; Humans; | 1979 |
Epilepsy and pregnancy. Serum thyroxine levels during phenytoin therapy.
Topics: Abnormalities, Drug-Induced; Administration, Oral; Epilepsy; Female; Fetus; Humans; Infant, Newborn; | 1979 |
Diphenylhydantoin during pregnancy.
Topics: Abnormalities, Drug-Induced; Animals; Female; Humans; Microsomes, Liver; Phenytoin; Pregnancy; Rats | 1979 |
Metabolism of diphenylhydantoin (phenytoin) during pregnancy.
Topics: Adolescent; Adult; Epilepsy; Female; Humans; Phenytoin; Postpartum Period; Pregnancy; Pregnancy Comp | 1979 |
Hemodialysis and pregnancy.
Topics: Acute Kidney Injury; Adolescent; Adult; Chloral Hydrate; Female; Glutethimide; Humans; Infant, Newbo | 1979 |
Anticonvulsant medication.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Child; Child, Preschool; Female; Fetus; Follow-Up Stud | 1979 |
Childhood cancer and drugs in pregnancy.
Topics: Adolescent; Adult; Child; Child, Preschool; Epilepsy; Female; Fetus; Humans; Infant; Infant, Newborn | 1979 |
Ganglioneuroblastoma and fetal hydantoin-alcohol syndromes.
Topics: Abnormalities, Drug-Induced; Child, Preschool; Female; Fetal Alcohol Spectrum Disorders; Humans; Kid | 1979 |
Pseudohyperphalangism in fetal Dilantin syndrome.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Child; Child, Preschool; Female; Fetus; Finger | 1979 |
Folate antagonism following teratogenic exposure to diphenylhydantoin.
Topics: Abnormalities, Drug-Induced; Animals; Female; Fetal Resorption; Fetus; Folic Acid Antagonists; Folic | 1979 |
Epilepsy and pregnancy.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Blood Coagulation Disorders; Chromosome Aberrations; C | 1979 |
Phenytoin (dilantin)-induced cleft lip and palate in A/J mice: a scanning and transmission electron microscopic study.
Topics: Animals; Cleft Lip; Cleft Palate; Female; Lip; Maternal-Fetal Exchange; Mice; Mice, Inbred Strains; | 1979 |
Phenytoin and carbamazepine in production of cleft palates in mice. Comparison of teratogenic effects.
Topics: Animals; Carbamazepine; Cleft Palate; Dose-Response Relationship, Drug; Female; Mice; Phenytoin; Pre | 1979 |
Kinetics of placentally transferred phenytoin and its p-hydroxylated metabolites in newborn infants.
Topics: Female; Humans; Hydroxylation; Infant, Newborn; Kinetics; Maternal-Fetal Exchange; Phenytoin; Placen | 1979 |
The side effects and interactions of antituberculosis drugs.
Topics: Adult; Aminosalicylic Acid; Antitubercular Agents; Central Nervous System Diseases; Chemical and Dru | 1979 |
DPH-induced macrocytosis in the 14-day rat foetus.
Topics: Anemia, Macrocytic; Animals; Female; Fetus; Maternal-Fetal Exchange; Phenytoin; Pregnancy; Rats | 1979 |
Prenatal programming of hepatic monoamine oxidase by 5,5-diphenylhydantoin.
Topics: Aging; Animals; Female; Hormones; Liver; Male; Maternal-Fetal Exchange; Monoamine Oxidase; Phenytoin | 1979 |
Problems in counseling the epileptic mother.
Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Barbiturates; Epilepsy; Female; Genetic Counseling; | 1979 |
Neuroblastoma in a child with the hydantoin and fetal alcohol syndrome. The radiographic features.
Topics: Abnormalities, Drug-Induced; Child, Preschool; Female; Fetal Alcohol Spectrum Disorders; Ganglioneur | 1979 |
[Fetal hydantoin syndrome (side effects of hydantoin preparations)].
Topics: Abnormalities, Drug-Induced; Epilepsy; Female; Fetal Diseases; Fetus; Humans; Infant, Newborn; Male; | 1979 |
Advances in understanding causes of childhood cancer.
Topics: Asbestos; Child; Diethylstilbestrol; Drug-Related Side Effects and Adverse Reactions; Environmental | 1979 |
Teratogenicity of therapeutic agents.
Topics: Abnormalities, Drug-Induced; Abnormalities, Radiation-Induced; Abortion, Induced; Anesthetics; Anima | 1979 |
Phenytoin, hemorrhage, skeletal defects and vitamin K in the newborn.
Topics: Abnormalities, Drug-Induced; Animals; Blood Coagulation Factors; Bone and Bones; Chick Embryo; Femal | 1979 |
A teratogenicity study on hydroxyurea and diphenylhydantoin in cats.
Topics: Abnormalities, Drug-Induced; Animals; Cats; Dose-Response Relationship, Drug; Drug Evaluation, Precl | 1979 |
Plasma anticonvulsant concentrations during pregnancy.
Topics: Epilepsy; Female; Humans; Phenobarbital; Phenytoin; Pregnancy; Pregnancy Complications | 1977 |
Status epilepticus in pregnancy: effect of phenytoin malabsorption on seizure control.
Topics: Administration, Oral; Adult; Female; Humans; Intestinal Absorption; Phenobarbital; Phenytoin; Postpa | 1978 |
The fetal hydantoin syndrome. A case report.
Topics: Abnormalities, Drug-Induced; Adult; Epilepsy; Female; Fetus; Humans; Hydantoins; Infant; Male; Pheny | 1978 |
[Choreoathetosis and orofacial dyskinesia during phenytoin treatment].
Topics: Adolescent; Adult; Athetosis; Chorea; Dyskinesia, Drug-Induced; Female; Humans; Male; Phenytoin; Pre | 1978 |
A failure to replicate cross-generational effects of diphenylhydantoin in an F1 offspring group.
Topics: Animals; Avoidance Learning; Female; Male; Maternal-Fetal Exchange; Phenytoin; Pregnancy; Rats | 1978 |
[A contribution to pharmacology and toxicology of injectable phenytoin solutions (author's transl].
Topics: Animals; Cats; Dogs; Female; Glycols; Hemodynamics; Hemolysis; Injections, Intra-Arterial; Injection | 1977 |
Malignant mesenchymoma and birth defects. Prenatal exposure to phenytoin.
Topics: Adolescent; Adult; Cleft Lip; Cleft Palate; Epilepsy; Female; Follow-Up Studies; Humans; Male; Mater | 1977 |
[Epilepsy and contraception].
Topics: Contraceptives, Oral; Contraceptives, Oral, Hormonal; Drug Interactions; Epilepsy; Female; Humans; O | 1977 |
A teratological evaluation of anticonvulsant drugs.
Topics: Abnormalities, Drug-Induced; Anencephaly; Anticonvulsants; Cleft Lip; Cleft Palate; Diazepam; Epilep | 1977 |
[Do antiepileptics have a teratogenic effect?].
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Congenital Abnormalities; Epilepsy; Female; Humans; In | 1978 |
Clinical investigation of the menstrual cycle. II. Neuroendocrine investigation and therapy of the inadequate luteal phase.
Topics: Adult; Electroencephalography; Female; Humans; Infertility, Female; Luteal Phase; Menstruation; Mens | 1978 |
Influence of cobalt (dietary), cobalamins, and inorganic cobalt salts on phenytoin- and cortisone-induced teratogenesis in mice.
Topics: Animals; Body Weight; Cobalt; Cortisone; Female; Fetus; Male; Maternal-Fetal Exchange; Mice; Organ S | 1978 |
Hematologic effects of phenytoin therapy during pregnancy.
Topics: Carotenoids; Epilepsy; Female; Folic Acid; Folic Acid Deficiency; Hematologic Tests; Humans; Phenyto | 1978 |
The effect of pregnancy on the metabolism of [14C]phenytoin in the isolated perfused rat liver.
Topics: Animals; Bile; Female; Glucuronates; Half-Life; Hydroxylation; In Vitro Techniques; Liver; Organ Siz | 1978 |
Kinetics of drug interactions in the treatment of epilepsy.
Topics: Animals; Anticonvulsants; Carbamazepine; Drug Interactions; Epilepsy; Ethanol; Female; Humans; Kinet | 1978 |
Fetal hydantoin syndrome in triplets. A unique experiment of nature.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adult; Epilepsy; Face; Female; Growth Disorder | 1978 |
Congenital malformations and seizure disorders in the offspring of parents with epilepsy.
Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Barbiturates; Child; Child, Preschool; Congenital Ab | 1978 |
Diphenylhydantoin teratogenicity in man.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adult; Female; Fingers; Humans; Infant; Infant | 1978 |
The effect of pregnancy on the biliary excretion of [14C]phenytoin in the rat.
Topics: Animals; Bile; Female; Glucuronates; Hydroxylation; Phenytoin; Pregnancy; Pregnancy, Animal; Rats; T | 1979 |
Seizures in adolescents.
Topics: Adolescent; Anticonvulsants; Automobile Driving; Benzodiazepines; Carbamazepine; Diagnosis, Differen | 1975 |
Phenytoin and phenobarbitone plasma clearance during pregnancy.
Topics: Adult; Epilepsies, Partial; Epilepsy; Epilepsy, Temporal Lobe; Epilepsy, Tonic-Clonic; Female; Human | 1976 |
Congenital malformations in four siblings of a mother taking anticonvulsant drugs.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Anticonvulsants; Child; Child, Preschool; Epil | 1976 |
Effect of prenatal phenytoin treatment on postnatal development [proceedings].
Topics: Animals; Female; Growth; Maternal-Fetal Exchange; Phenytoin; Pregnancy; Rats | 1977 |
Neonatal hypocalcaemia after intrauterine exposure to anticonvulsant drugs.
Topics: Adult; Female; Humans; Hypocalcemia; Infant, Newborn; Infant, Newborn, Diseases; Male; Maternal-Feta | 1977 |
A comparison of the teratogenic activity of the antiepileptic drugs carbamazepine, clonazepam, ethosuximide, phenobarbital, phenytoin, and primidone in mice.
Topics: Abnormalities, Drug-Induced; Animals; Anticonvulsants; Carbamazepine; Clonazepam; Ethosuximide; Fema | 1977 |
Phenytoin: an evaluation of several potential teratogenic mechanisms.
Topics: Animals; Cerebellum; Cerebral Cortex; Cytochrome P-450 Enzyme System; Female; Fetal Blood; Fetus; Fo | 1977 |
Phenytoin teratogenesis: correlation between embryopathic effect and covalent binding of putative arene oxide metabolite in gestational tissue.
Topics: Animals; Chromatography, Thin Layer; Epoxide Hydrolases; Epoxy Compounds; Ethers, Cyclic; Female; Fe | 1977 |
Letter: Glaucoma associated with the fetal hydantoin syndrome.
Topics: Adult; Female; Fetus; Glaucoma; Humans; Infant; Phenytoin; Pregnancy | 1976 |
Cardiac defects in children of mothers receiving anticonvulsant therapy during pregnancy.
Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Anticonvulsants; Cleft Lip; Cleft Palate; Dimethadio | 1976 |
The effect of cortisone on the teratogenic action of acetylsalicylic acid and diphenylhydantoin in the mouse.
Topics: Abnormalities, Drug-Induced; Animals; Aspirin; Cleft Palate; Cortisone; Drug Administration Schedule | 1976 |
Teratogenic effect of anticonvulsant drugs.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Acetazolamide; Anticonvulsants; Child; Child, | 1976 |
Fetal malformations and antiepileptic drugs.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Barbiturates; Ethanol; Female; Humans; Infant; Infant, | 1976 |
Kinetics of phenytoin in pregnant and non-pregnant rats.
Topics: Animals; Blood Proteins; Female; Half-Life; Kinetics; Phenytoin; Pregnancy; Protein Binding; Rats | 1976 |
Drug stimulated biotransformation of hormonal steroid contraceptives: clinical implications.
Topics: Ampicillin; Biotransformation; Carbamazepine; Contraceptives, Oral; Contraceptives, Oral, Hormonal; | 1976 |
Teratogens in the human: current problems.
Topics: Abnormalities, Drug-Induced; Barbiturates; Contraceptives, Oral; Ethanol; Female; Fetal Diseases; Hu | 1976 |
Teratogenic activity of the antiepileptic drugs phenobarbital, phenytoin, and primidone in mice.
Topics: Animals; Cleft Palate; Drug Interactions; Female; Gestational Age; Leucovorin; Maternal-Fetal Exchan | 1975 |
Teratogenicity of oral diazepam and diphenylhydantoin in mice.
Topics: Abnormalities, Drug-Induced; Animals; Body Weight; Cleft Palate; Diazepam; Female; Fetal Death; Fetu | 1975 |
Chromosomes and anticonvulsant drugs.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Cells, Cultured; Chromatids; Chromosome Aberrations; C | 1975 |
Clinical applications of gas chromatograph/mass spectrometer/computer systems.
Topics: Autoanalysis; Caffeine; Chromatography, Gas; Computers; Diazepam; Evaluation Studies as Topic; Femal | 1975 |
Thyroid-function tests in diphenylhydantoin-treated patients.
Topics: Adult; Binding, Competitive; Female; Humans; Male; Phenytoin; Pregnancy; Protein Binding; Seizures; | 1975 |
Maternal phenytoin ingestion and congenital abnormalities: report of a case.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adult; Anus, Imperforate; Bladder Exstrophy; E | 1975 |
Teratogenic effects of diphenylhydantoin.
Topics: Abnormalities, Drug-Induced; Adult; Breast; Epilepsy; Face; Female; Hernia, Inguinal; Hip Dislocatio | 1975 |
Congenital malformations due to anticonvulsive drugs.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adult; Anencephaly; Anticonvulsants; Birth Ord | 1975 |
Absorption and distribution of antiepileptic drugs.
Topics: Administration, Oral; Animals; Anticonvulsants; Capsules; Carbamazepine; Female; Humans; Injections, | 1975 |
Studies of the development of congenital anomalies in rats. III. Effects of inhibition of mitochondrial energy systems on embryonic development.
Topics: Abnormalities, Drug-Induced; Animals; Bone and Bones; Chloramphenicol; Diet; Embryo Implantation; En | 1975 |
Ultrastructural changes in the cerebellum of young rats having received diphenylhydantoin during the embryonal stage.
Topics: Animals; Cerebellum; Embryo, Mammalian; Female; Maternal-Fetal Exchange; Phenytoin; Pregnancy; Rats | 1975 |
Epilepsy anticonvulsants and malformations.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Cleft Lip; Cleft Palate; Epilepsy; Female; Heart Defec | 1975 |
Adrenal cortical function in abnormal newborn infants.
Topics: Adrenal Cortex; Adrenal Cortex Hormones; Adrenal Glands; Barbiturates; Female; Fetal Diseases; Gesta | 1975 |
Differences due to species, sex and pregnancy in microsomal induction by diphenylhydantoin in rabbits and rats.
Topics: Animals; Enzyme Induction; Female; Male; Microsomes, Liver; Mixed Function Oxygenases; Phenytoin; Pr | 1975 |
Limb malformations following maternal use of haloperidol.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Drug Therapy, Combination; Female; Fetus; Halo | 1975 |
Phenytoin (diphenylhydantoin).
Topics: Arrhythmias, Cardiac; Behavior; Female; Humans; Infant, Newborn; Mental Disorders; Phenytoin; Pregna | 1976 |
Letter: Dilantin therapy.
Topics: Female; Folic Acid; Humans; Hypoxia; Phenytoin; Pregnancy | 1976 |
[Influence of neuropharmaca on hormonal contraception].
Topics: Adolescent; Adult; Anticonvulsants; Chlorpromazine; Contraceptives, Oral; Contraceptives, Oral, Horm | 1976 |
[2 patients with brain metastases who became pregnant during phenytoin administration].
Topics: Abortion, Therapeutic; Adult; Brain Neoplasms; Carcinoma, Non-Small-Cell Lung; Choriocarcinoma; Cont | 1992 |
Salivary concentrations of antiepileptic drugs, oestradiol and progesterone throughout pregnancy in epileptic women.
Topics: Adult; Anticonvulsants; Carbamazepine; Epilepsy; Estradiol; Female; Humans; Osmolar Concentration; P | 1992 |
Diphenylhydantoin is not genotoxic in a battery of short-term cytogenetic assays.
Topics: Animals; Biotransformation; CHO Cells; Chromosome Aberrations; Cricetinae; Female; Liver; Male; Mate | 1992 |
The efficacy of phenytoin in relation to serum levels in severe pre-eclampsia and eclampsia.
Topics: Adolescent; Adult; Dose-Response Relationship, Drug; Eclampsia; Female; Humans; Phenytoin; Pre-Eclam | 1992 |
Phenytoin metabolism during pregnancy.
Topics: Epilepsy; Female; Humans; Phenytoin; Pregnancy; Pregnancy Complications; Time Factors | 1992 |
Histopathological and hemodynamic studies supporting hypoxia and vascular disruption as explanation to phenytoin teratogenicity.
Topics: Abnormalities, Drug-Induced; Animals; Facial Bones; Female; Fetal Hypoxia; Gestational Age; Heart Ra | 1992 |
Binder's syndrome due to prenatal vitamin K deficiency: a theory of pathogenesis.
Topics: Adolescent; Alcoholism; Aneurysm, Ruptured; Animals; Cartilage; Child, Preschool; Female; Humans; In | 1992 |
Inhibition of phenytoin bioactivation and teratogenicity by dietary n-3 fatty acids in mice.
Topics: Abnormalities, Drug-Induced; Animals; Biotransformation; Coconut Oil; Cytochrome P-450 Enzyme System | 1992 |
Embryotoxicity of phenytoin in adrenalectomized CD-1 mice.
Topics: Abnormalities, Drug-Induced; Adrenalectomy; Animals; Cleft Palate; Corticosterone; Female; Fetal Res | 1992 |
Pregnancy complicated by acute mania and preeclampsia.
Topics: Acute Disease; Adult; Bipolar Disorder; Female; Humans; Lithium; Phenytoin; Pre-Eclampsia; Pregnancy | 1992 |
Antiepileptic drug disposition during pregnancy.
Topics: Adult; Anticonvulsants; Carbamazepine; Female; Humans; Phenobarbital; Phenytoin; Pregnancy; Valproic | 1992 |
Clinical and experimental studies linking oxidative metabolism to phenytoin-induced teratogenesis.
Topics: Abnormalities, Drug-Induced; Amnion; Animals; Anticonvulsants; Body Weight; Dioxolanes; Epoxide Hydr | 1992 |
Pharmacogenetics and drug interactions: role in antiepileptic-drug-induced teratogenesis.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Disease Susceptibility; Epilepsy; Epoxide Hydrolases; | 1992 |
Epilepsy, antiepileptic drugs, and malformations in children of women with epilepsy: a French prospective cohort study.
Topics: Abnormalities, Drug-Induced; Adult; Anticonvulsants; Cohort Studies; Epilepsy; Female; Humans; Odds | 1992 |
Antiepileptic drugs and teratogenesis in two consecutive cohorts: changes in prescription policy paralleled by changes in pattern of malformations.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Carbamazepine; Cohort Studies; Drug Prescriptions; Epi | 1992 |
Course of pregnancy and fetal outcome following maternal exposure to carbamazepine and phenytoin: a prospective study.
Topics: Abnormalities, Drug-Induced; Analysis of Variance; Carbamazepine; Epilepsy; Female; Humans; Phenytoi | 1992 |
Severe post-partum eclampsia: response to plasma exchange.
Topics: Adult; Blood Transfusion; Cesarean Section; Combined Modality Therapy; Dexamethasone; Eclampsia; Fem | 1992 |
Identical phalangeal defects induced by phenytoin and nifedipine suggest fetal hypoxia and vascular disruption behind phenytoin teratogenicity.
Topics: Abnormalities, Drug-Induced; Animals; Blood Vessels; Female; Fetal Hypoxia; Gestational Age; Heart R | 1992 |
Comparison of the behavioral teratogenic potential of phenytoin, mephenytoin, ethotoin, and hydantoin in rats.
Topics: Animals; Behavior, Animal; Ear, Inner; Female; Hydantoins; Male; Mephenytoin; Phenytoin; Pregnancy; | 1991 |
Carbamazepine blocks NMDA-activated currents in cultured spinal cord neurons.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Carbamazepine; Cells, Cultured; Dizocilpine Malea | 1990 |
Phenytoin teratogenicity and midgestational pharmacokinetics in mice.
Topics: Abnormalities, Drug-Induced; Animals; Dose-Response Relationship, Drug; Female; Fetal Death; Gestati | 1991 |
The effect of administration time on malformations induced by three anticonvulsant agents in C57BL/6J mice with emphasis on forelimb ectrodactyly.
Topics: Abnormalities, Drug-Induced; Animals; Anophthalmos; Anticonvulsants; Dimethadione; Facial Bones; Fem | 1991 |
[Effects of antiepileptic drugs on delivery and early childhood--comparison among mono-therapies of valproic acid, phenytoin, carbamazepine and phenobarbital].
Topics: Abnormalities, Drug-Induced; Adult; Anticonvulsants; Birth Weight; Carbamazepine; Embryonic and Feta | 1991 |
Common biochemical pathway of dysmorphogenesis in murine embryos: use of the glucocorticoid pathway by phenytoin.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Cortodoxone; Cyclooxygenase Inhibitors; Embryo, Mammal | 1990 |
Management of epilepsy.
Topics: Adult; Diazepam; Drug Administration Schedule; Female; Humans; Injections, Intravenous; Monitoring, | 1990 |
Thanatophoric dwarfism; drugs and antenatal diagnosis; a case report.
Topics: Abnormalities, Drug-Induced; Amitriptyline; Female; Humans; Infant, Newborn; Male; Phenobarbital; Ph | 1991 |
Fetal phenytoin exposure, hypoplastic nails, and jitteriness.
Topics: Abnormalities, Drug-Induced; Akathisia, Drug-Induced; Epilepsy; Female; Fetus; Humans; Infant, Newbo | 1991 |
Permanent alterations in the hypothalamic-pituitary-thyroid axis in the rat following phenytoin exposure in utero.
Topics: Animals; Body Weight; Female; Hypothalamo-Hypophyseal System; Maternal-Fetal Exchange; Phenytoin; Pr | 1990 |
Induction of postaxial forelimb ectrodactyly with anticonvulsant agents in A/J mice.
Topics: Abnormalities, Drug-Induced; Animals; Birth Weight; Dimethadione; Female; Fetal Death; Fetal Resorpt | 1990 |
Possible roles for frequent salivary antiepileptic drug monitoring in the management of epilepsy.
Topics: Adult; Anticonvulsants; Carbamazepine; Epilepsies, Partial; Epilepsy; Female; Humans; Male; Menstrua | 1990 |
Developmental toxicity and pharmacokinetics of oral and intravenous phenytoin in the rat.
Topics: Abnormalities, Drug-Induced; Administration, Oral; Animals; Body Weight; Female; Fetal Resorption; H | 1990 |
Developmental toxicity and pharmacokinetics of phenytoin in the rhesus macaque: an interspecies comparison.
Topics: Abnormalities, Drug-Induced; Animals; Embryo, Mammalian; Female; Fetus; Fluorescence Polarization Im | 1990 |
Neocerebellar hypoplasia in a neonate following intra-uterine exposure to anticonvulsants.
Topics: Abnormalities, Drug-Induced; Cerebellum; Drug Therapy, Combination; Epilepsy; Female; Humans; Nerve | 1990 |
Foetal hydantoin syndrome.
Topics: Abnormalities, Multiple; Clubfoot; Epilepsy; Facial Bones; Female; Humans; Infant, Newborn; Phenytoi | 1990 |
Effects of exposure period and nutrition on the developmental neurotoxicity of anticonvulsants in rats: short and long-term effects.
Topics: Animal Nutritional Physiological Phenomena; Animals; Anticonvulsants; Female; Male; Manganese; Nervo | 1990 |
Protein binding of antiepileptic drugs during pregnancy, labor, and puerperium.
Topics: Adult; Anticonvulsants; Carbamazepine; Fatty Acids, Nonesterified; Female; Fetal Blood; Humans; Labo | 1990 |
Status epilepticus in pregnancy. A case report.
Topics: Adult; Female; Humans; Phenytoin; Pregnancy; Pregnancy Complications; Status Epilepticus | 1990 |
Distal phalangeal hypoplasia in children with prenatal phenytoin exposure: results of a controlled anthropometric study.
Topics: Anthropometry; Bone Diseases, Developmental; Child, Preschool; Dose-Response Relationship, Drug; Fem | 1990 |
Prenatal prediction of risk of the fetal hydantoin syndrome.
Topics: Abnormalities, Drug-Induced; Amniocentesis; Amniotic Fluid; Anticonvulsants; Biomarkers; Epoxide Hyd | 1990 |
[Therapeutic drug monitoring of phenytoin].
Topics: Adolescent; Adult; Age Factors; Biological Availability; Child; Child, Preschool; Dosage Forms; Drug | 1990 |
Use of Frog Embryo Teratogenesis Assay-Xenopus and an exogenous metabolic activation system to evaluate the developmental toxicity of diphenylhydantoin.
Topics: Abnormalities, Drug-Induced; Animals; Biotransformation; Cimetidine; Cyclohexanes; Cyclohexenes; Dos | 1990 |
Head circumference in children of epileptic mothers: contributions of drug exposure and genetic background.
Topics: Adult; Anticonvulsants; Carbamazepine; Child, Preschool; Epilepsy; Female; Humans; Intelligence Test | 1990 |
Pharmacokinetics of anticonvulsants in pregnancy: alterations in plasma protein binding.
Topics: Adult; Anticonvulsants; Blood Proteins; Carbamazepine; Epilepsy; Female; Humans; Maternal-Fetal Exch | 1990 |
Single high dose of intravenous phenytoin sodium for the treatment of eclampsia.
Topics: Eclampsia; Female; Humans; Infusions, Intravenous; Monitoring, Physiologic; Phenytoin; Pregnancy; Ti | 1990 |
Prenatal phenytoin exposure decreases neuronal membrane order in rat offspring hippocampus.
Topics: Aging; Animals; Brain; Cell Membrane; Cerebellum; Cerebral Cortex; Diphenylhexatriene; Female; Hippo | 1990 |
[Effect of diphenylhydantoin sodium in causing deformity and that of folic acid preparations for its prevention].
Topics: Abnormalities, Drug-Induced; Animals; Female; Folic Acid; Phenytoin; Pregnancy; Rats; Rats, Inbred S | 1990 |
Phenytoin and magnesium sulfate in eclampsia.
Topics: Female; Humans; Magnesium Sulfate; Phenytoin; Pre-Eclampsia; Pregnancy | 1990 |
Intelligence of children of epileptic mothers.
Topics: Child, Preschool; Developmental Disabilities; Epilepsy; Female; Humans; Intelligence; Intelligence T | 1988 |
Modulation of phenytoin teratogenicity and embryonic covalent binding by acetylsalicylic acid, caffeic acid, and alpha-phenyl-N-t-butylnitrone: implications for bioactivation by prostaglandin synthetase.
Topics: Abnormalities, Drug-Induced; Animals; Aspirin; Biotransformation; Caffeic Acids; Cinnamates; Cyclic | 1989 |
Fetal hydantoin syndrome: a case report.
Topics: Abnormalities, Drug-Induced; Diagnosis, Differential; Epilepsy, Tonic-Clonic; Face; Female; Fingers; | 1989 |
The relation between phenytoin-receptor and glucocorticoid in the induction of cleft palate with phenytoin in mice.
Topics: Abnormalities, Drug-Induced; Animals; Binding, Competitive; Cleft Palate; Cytosol; Female; Lung; Mic | 1989 |
The fetal hydantoin syndrome: answers from a mouse model.
Topics: Abnormalities, Drug-Induced; Animals; Body Weight; Disease Models, Animal; Embryo Implantation; Fema | 1989 |
[Comparison of the teratogenic properties manifested in BALB c mice, by diphenylhydantoin and deuterated diphenylhydantoin].
Topics: Abnormalities, Drug-Induced; Animals; Cleft Palate; Deuterium; Female; Mice; Mice, Inbred BALB C; Ph | 1989 |
[The fetal hydantoin syndrome].
Topics: Adult; Epilepsy; Female; Hand Deformities, Congenital; Humans; Hypospadias; Infant, Newborn; Male; M | 1989 |
Phenytoin in pre-eclampsia.
Topics: Female; Humans; Phenytoin; Pre-Eclampsia; Pregnancy; Seizures | 1989 |
Phenytoin in pre-eclampsia.
Topics: Female; Humans; Phenytoin; Pre-Eclampsia; Pregnancy; Seizures | 1989 |
Chronic phenytoin treatment decreases GABAA but not beta-adrenoceptors in the cerebellum of young rats.
Topics: Adrenergic beta-Antagonists; Animals; Autoradiography; Cerebellum; Female; Flunitrazepam; Kinetics; | 1989 |
Clinical experience with phenytoin prophylaxis in severe preeclampsia.
Topics: Athetosis; Cesarean Section; Chorea; Delivery, Obstetric; Drug Administration Schedule; Female; Huma | 1989 |
Effects of the tumor promoter 12-O-tetradecanoylphorbol-13-acetate on phenytoin-induced embryopathy in mice.
Topics: Animals; Dose-Response Relationship, Drug; Female; Fetal Death; Fetal Resorption; Fetus; Mice; Pheny | 1989 |
Inhibition of trimethadione and dimethadione teratogenicity by the cyclooxygenase inhibitor acetylsalicylic acid: a unifying hypothesis for the teratologic effects of hydantoin anticonvulsants and structurally related compounds.
Topics: Abnormalities, Drug-Induced; Animals; Aspirin; Cleft Palate; Dealkylation; Dimethadione; Dose-Respon | 1989 |
Maternofetal transfer of phenytoin, p-hydroxy-phenytoin and p-hydroxy-phenytoin-glucuronide in the perfused human placenta.
Topics: Animals; Antipyrine; Female; Humans; In Vitro Techniques; Male; Maternal-Fetal Exchange; Metabolic C | 1989 |
[Phenytoin].
Topics: Child; Female; Humans; Phenytoin; Pregnancy | 1989 |
Teratogenicity of phenylhydantoins in an in vitro system: molecular orbital-generated quantitative structure-toxicity relationships.
Topics: Animals; Cells, Cultured; Female; Hydantoins; Molecular Conformation; Phenytoin; Pregnancy; Rats; St | 1989 |
Anti-convulsant therapy in eclampsia.
Topics: Adult; Anticonvulsants; Diazepam; Drug Therapy, Combination; Eclampsia; Female; Humans; Infant Morta | 1989 |
Teratogenic effects of phenytoin on chick embryos.
Topics: Abnormalities, Drug-Induced; Animals; Body Weight; Chick Embryo; Dose-Response Relationship, Drug; E | 1989 |
[Preventive effects of fortified pollen on diphenylhydantoin teratogenesis].
Topics: Abnormalities, Drug-Induced; Animals; Drug Synergism; Female; Folic Acid; Phenytoin; Pollen; Pregnan | 1989 |
Fetal hydantoin syndrome?
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Female; Humans; Infant, Newborn; Phenytoin; Pr | 1989 |
Extension of the analysis of the time structure of behavioral acts.
Topics: Animals; Behavior, Animal; Female; Male; Nitrous Oxide; Phenytoin; Pregnancy; Prenatal Exposure Dela | 1989 |
Value of saliva anticonvulsant monitoring in pregnancy and the newborn.
Topics: Anticonvulsants; Carbamazepine; Female; Humans; Infant, Newborn; Monitoring, Physiologic; Phenobarbi | 1989 |
Determination of enzyme or binding constants using generalized linear models, with particular reference to Michaelis-Menten models.
Topics: Adult; Enzymes; Epilepsy; Female; Humans; Models, Biological; Pharmacokinetics; Phenytoin; Pregnancy | 1989 |
Modulation of embryonic glutathione reductase and phenytoin teratogenicity by 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU).
Topics: Animals; Carmustine; Cleft Palate; Drug Interactions; Embryo, Mammalian; Female; Fetal Resorption; G | 1989 |
Pregnancy and epilepsy.
Topics: Abnormalities, Drug-Induced; Adult; Anticonvulsants; Carbamazepine; Epilepsy; Estrogens; Female; Hum | 1989 |
Enhancement of murine phenytoin teratogenicity by the gamma-glutamylcysteine synthetase inhibitor L-buthionine-(S,R)-sulfoximine and by the glutathione depletor diethyl maleate.
Topics: Administration, Oral; Analysis of Variance; Animals; Body Weight; Buthionine Sulfoximine; Cleft Pala | 1989 |
The effect of pregnancy in humans on the pharmacokinetics of stable isotope labelled phenytoin.
Topics: Adult; Blood Proteins; Carbon Isotopes; Female; Humans; Models, Biological; Phenytoin; Pregnancy; Pr | 1989 |
Prenatal exposure to phenytoin and its effect on postnatal growth and craniofacial proportion in the rat.
Topics: Abnormalities, Drug-Induced; Animals; Body Weight; Bone Development; Eye Abnormalities; Face; Female | 1989 |
Prenatal ossification as an indicator of exposure to toxic agents.
Topics: Acetazolamide; Animals; Bromodeoxyuridine; Cervical Vertebrae; Cortisone; Female; Mice; Osteogenesis | 1989 |
[Possible adverse effects of phenytoin given transplacentally on the fetal growth. III. Effects of phenytoin on postnatal brain development].
Topics: 2',3'-Cyclic Nucleotide 3'-Phosphodiesterase; 2',3'-Cyclic-Nucleotide Phosphodiesterases; Animals; B | 1988 |
Genetic predisposition to phenytoin-induced birth defects.
Topics: Abnormalities, Multiple; Child; Epilepsy; Female; Humans; Phenytoin; Pregnancy | 1985 |
Cardiovascular defects in rat embryos cultured on serum from rats chronically exposed to phenytoin.
Topics: Animals; Drug Administration Schedule; Ectogenesis; Embryo, Mammalian; Female; Heart; Heart Defects, | 1986 |
Relationship between ossification and body weight of the CD-1 mouse fetus exposed in utero to anticonvulsant drugs.
Topics: Animals; Anticonvulsants; Body Weight; Carbamazepine; Dose-Response Relationship, Drug; Female; Fetu | 1986 |
Phenytoin infusion in severe pre-eclampsia.
Topics: Female; Fetus; Humans; Infant, Newborn; Infusions, Intravenous; Phenytoin; Pre-Eclampsia; Pregnancy; | 1987 |
Correlations between embryotoxic and genotoxic effects of phenytoin in mice.
Topics: Abnormalities, Drug-Induced; Animals; Biotransformation; Cell Nucleus; Cytochrome P-450 CYP1A2; Cyto | 1987 |
Phenytoin infusion in severe pre-eclampsia.
Topics: Female; Humans; Phenytoin; Pre-Eclampsia; Pregnancy | 1987 |
Variable patterns in anticonvulsant drug-induced malformations in mice: comparisons of phenytoin and phenobarbital.
Topics: Abnormalities, Drug-Induced; Animals; Female; Fetal Growth Retardation; Mice; Mice, Inbred Strains; | 1987 |
Effects of N-acetylcysteine on fetal development and on phenytoin teratogenicity in mice.
Topics: Acetylcysteine; Animals; Embryonic and Fetal Development; Female; Mice; Mice, Inbred Strains; Phenyt | 1988 |
[Typical hydantoin syndrome in a child of a non-epileptic mother].
Topics: Abnormalities, Drug-Induced; Female; Humans; Infant, Newborn; Male; Phenytoin; Pregnancy; Syndrome | 1986 |
Effects of diazepam, tofizopam or phenytoin during foetal development on subsequent behaviour and benzodiazepine receptor characteristics in rats.
Topics: Animals; Anti-Anxiety Agents; Behavior, Animal; Benzodiazepines; Diazepam; Female; Fetus; Maternal-F | 1986 |
Enhanced metabolism of levonorgestrel during phenytoin treatment in a woman with Norplant implants.
Topics: Adult; Drug Interactions; Epilepsy; Female; Humans; Kinetics; Levonorgestrel; Menstruation; Norgestr | 1986 |
[Combination of hydantoins and valproate. Evidence of its teratogenic effect in 4 consecutive gestations].
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Child; Child, Preschool; Drug Therapy, Combina | 1986 |
Anticonvulsant drugs in monotherapy. Effect on the fetus.
Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Anticonvulsants; Carbamazepine; Epilepsy; Female; Fe | 1987 |
Postpartum spinal wedge fractures in a 27-year-old epileptic anorectic woman.
Topics: Adult; Anorexia Nervosa; Epilepsy, Tonic-Clonic; Female; Fractures, Spontaneous; Humans; Osteoporosi | 1987 |
The role of ultrasound in the early diagnosis of fetal structural defects following maternal anticonvulsant therapy.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Carbamazepine; Diazepam; Female; Humans; Infant, Newbo | 1988 |
Factors causing age-dependent changes in phenytoin tissue and serum binding in rats.
Topics: Aging; Animals; Blood Proteins; Fatty Acids, Nonesterified; Female; Male; Phenytoin; Phospholipids; | 1988 |
Phenytoin-induced stress protein synthesis in mouse embryonic tissue.
Topics: Animals; Electrophoresis, Polyacrylamide Gel; Embryo, Mammalian; Facial Bones; Female; Forelimb; Hea | 1988 |
Alterations in maternal plasma corticosterone levels following treatment with phenytoin.
Topics: Animals; Corticosterone; Female; Mice; Mice, Inbred A; Mice, Inbred C57BL; Phenytoin; Pregnancy; Rad | 1988 |
[Possible adverse effects of phenytoin given transplacentally on the fetal growth. I. Transplacental transmission of phenytoin].
Topics: Animals; Embryonic and Fetal Development; Female; Fetus; Maternal-Fetal Exchange; Mice; Phenytoin; P | 1988 |
[Possible adverse effects of phenytoin given transplacentally on the fetal growth. II. Possible adverse effects on the fetal growth].
Topics: Animals; Embryonic and Fetal Development; Female; Maternal-Fetal Exchange; Mice; Phenytoin; Placenta | 1988 |
Increased sharing of maternal HLA haplotypes among children exposed to diphenylhydantoin during pregnancy.
Topics: Child; Female; Haplotypes; HLA Antigens; Humans; Maternal-Fetal Exchange; Phenytoin; Pregnancy | 1988 |
Disposition of phenytoin and phenobarbitone in the isolated perfused human placenta.
Topics: Biotransformation; Carbon Radioisotopes; Female; Humans; Maternal-Fetal Exchange; Perfusion; Phenoba | 1988 |
In vivo evaluation in the lactating rabbit of a model for xenobiotic distribution into breast milk.
Topics: Animals; Diazepam; Female; Hydrogen-Ion Concentration; Lactation; Milk; Models, Biological; Phenobar | 1988 |
Minor anomalies in offspring of epileptic mothers.
Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Child; Child, Preschool; Congenital Abnormalities; E | 1988 |
Clonazepam in breast milk.
Topics: Clonazepam; Female; Humans; Infant, Newborn; Milk, Human; Phenytoin; Pregnancy | 1988 |
Onychopathy in a patient with fetal hydantoin syndrome.
Topics: Epilepsy; Female; Humans; Infant; Nail Diseases; Nails; Phenytoin; Pregnancy; Pregnancy Complication | 1988 |
Family studies in fetal phenytoin exposure.
Topics: Abnormalities, Drug-Induced; Child; Embryonic and Fetal Development; Family; Fathers; Female; Humans | 1988 |
Predictive value of minor anomalies: II. Use in cohort studies to identify teratogens.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Congenital Abnormalities; Diabetes Mellitus, Type 1; F | 1987 |
Elevated glucocorticoid receptor levels in lymphocytes of children with the fetal hydantoin syndrome (FHS).
Topics: Abnormalities, Drug-Induced; Child; Female; Fetal Diseases; Humans; Hydantoins; Lymphocytes; Phenyto | 1987 |
Age-dependent changes in phenytoin tissue bindings in rats: comparison between in vivo and in vitro tissue-to-blood partition coefficients (Kp values) of phenytoin.
Topics: Aging; Animals; Body Water; Female; In Vitro Techniques; Male; Phenytoin; Pregnancy; Rats; Rats, Inb | 1987 |
Fetal anticonvulsant exposure: effects on behavioral and physical development.
Topics: Animals; Anticonvulsants; Female; Humans; Learning; Memory; Motor Activity; Oxazoles; Phenobarbital; | 1986 |
Modifications of the thymus and splenic thymic dependent zones after in utero exposure to phenytoin: qualitative and quantitative analysis in C3H mice.
Topics: Animals; Female; Maternal-Fetal Exchange; Mice; Mice, Inbred C3H; Phenytoin; Pregnancy; Spleen; T-Ly | 1987 |
Possible prenatal hydantoin effect in a child born to a nonepileptic mother.
Topics: Abnormalities, Drug-Induced; Adult; Arteriovenous Malformations; Cerebral Hemorrhage; Dermatoglyphic | 1987 |
Total testosterone, free-androgen index, calculated free testosterone, and free testosterone by analog RIA compared in hirsute women and in otherwise-normal women with altered binding of sex-hormone-binding globulin.
Topics: Androgens; Contraceptives, Oral; Female; Hirsutism; Humans; Mathematics; Phenytoin; Pregnancy; Radio | 1987 |
Fetal hydantoin syndrome in rats: dose-effect relationships of prenatal phenytoin on postnatal development and behavior.
Topics: Animals; Behavior, Animal; Dose-Response Relationship, Drug; Female; Fetus; Growth; Male; Maternal-F | 1987 |
Serum phenytoin during pregnancy, labor and puerperium.
Topics: Adult; Epilepsy; Female; Humans; Labor, Obstetric; Osmolar Concentration; Phenytoin; Postpartum Peri | 1987 |
Age-dependent changes in phenytoin tissue distribution in rats.
Topics: Aging; Animals; Blood Proteins; Female; Injections, Intravenous; Phenytoin; Pregnancy; Protein Bindi | 1987 |
Developmental profile of serum androgens and estrous cyclicity of male and female rats exposed, perinatally, to maternally administered phenytoin.
Topics: Androgens; Animals; Body Weight; Dose-Response Relationship, Drug; Estrus; Female; Fetus; Male; Phen | 1987 |
Effect of route of administration on phenytoin teratogenicity in A/J mice.
Topics: Abnormalities, Drug-Induced; Animals; Cleft Lip; Cleft Palate; Diet; Female; Fetal Resorption; Injec | 1986 |
Persistent defects in the hepatic monooxygenase system of adult rats exposed, perinatally, to maternally administered phenytoin.
Topics: Aminopyrine N-Demethylase; Animals; Body Weight; Female; Kinetics; Liver; Male; Microsomes, Liver; M | 1986 |
Pharmacological studies on the potentiation of phenytoin teratogenicity by acetaminophen.
Topics: Abnormalities, Drug-Induced; Acetaminophen; Animals; Brain; Cleft Palate; Drug Synergism; Embryo Los | 1986 |
Epilepsy and pregnancy.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Epilepsy; Female; Humans; Infant Care; Infant, Newborn | 1986 |
Developmental effects of anticonvulsants.
Topics: Animals; Anticonvulsants; Body Weight; Epilepsy; Female; Fetal Diseases; Humans; Motor Activity; Phe | 1986 |
Delayed development of reproductive functions and alteration of dopamine receptor binding in hypothalamus of rats exposed prenatally to phenytoin and phenobarbital.
Topics: Animals; Female; Hypothalamus; Male; Phenobarbital; Phenytoin; Pregnancy; Prenatal Exposure Delayed | 1986 |
Phenytoin kinetics during pregnancy and the puerperium.
Topics: Adult; Epilepsy; Female; Fetal Blood; Humans; Kinetics; Phenytoin; Postpartum Period; Pregnancy; Pre | 1986 |
Primary left ventricular rhabdomyosarcoma in a child: noninvasive assessment and successful resection of a rare tumor.
Topics: Child, Preschool; Echocardiography; Female; Heart Neoplasms; Heart Ventricles; Humans; Phenytoin; Pr | 1987 |
Cortical blindness and late postpartum eclampsia.
Topics: Adult; Blindness; Eclampsia; Female; Humans; Magnesium Sulfate; Phenytoin; Pregnancy; Puerperal Diso | 1987 |
Phenytoin teratogenicity and effects on embryonic and maternal folate metabolism [published errtum appears in Teratology 1986 Dec;34(3):487].
Topics: Abnormalities, Drug-Induced; Animals; Embryo Implantation; Female; Folic Acid; Litter Size; Liver; M | 1985 |
The effects of long-term anticonvulsant drug therapy on vitamin D metabolites and mineral homeostasis in pregnant epileptic women and their newborns.
Topics: Adolescent; Adult; Anticonvulsants; Calcifediol; Calcitriol; Carbamazepine; Dihydroxycholecalciferol | 1985 |
Lack of maternal metabolic, endocrine, and environmental influences in the etiology of cleft lip with or without cleft palate.
Topics: Adult; Cleft Lip; Cleft Palate; Drug Interactions; Endocrine Glands; Erythrocytes; Female; Folic Aci | 1985 |
Examination of infants for both minor and major malformations to evaluate for possible teratogenic exposures.
Topics: Abnormalities, Drug-Induced; Diabetes Mellitus, Type 1; Epilepsy; Female; Gonadal Steroid Hormones; | 1985 |
Effects of pregnancy on seizure threshold and the disposition and efficacy of antiepileptic drugs in the mouse.
Topics: Animals; Anticonvulsants; Carbamazepine; Electroshock; Female; Kinetics; Mice; Phenobarbital; Phenyt | 1985 |
Effects of pregnancy on antiepileptic drug utilization.
Topics: Anticonvulsants; Biological Availability; Carbamazepine; Epilepsy; Female; Humans; Kinetics; Metabol | 1985 |
[Drug therapy in eclampsia].
Topics: Blood Pressure; Cerebrovascular Circulation; Cesarean Section; Dexamethasone; Dihydralazine; Dobutam | 1985 |
Free triiodothyronine in serum in relation to thyroid function.
Topics: Adult; Female; Humans; Male; Middle Aged; Neoplasms; Phenytoin; Pregnancy; Radioimmunoassay; Thyroid | 1985 |
Seizure disorders and pregnancy.
Topics: Carbamazepine; Female; Humans; Phenytoin; Pregnancy; Pregnancy Complications; Seizures | 1986 |
Maternal anticonvulsants and fetal hemorrhage. A report of two cases.
Topics: Adolescent; Adult; Cesarean Section; Epilepsy; Female; Fetal Diseases; Hemorrhage; Hemostasis; Human | 1986 |
Potentiation of the teratogenic effects and altered disposition of diphenylhydantoin in mice fed a purified diet.
Topics: Analysis of Variance; Animals; Cleft Palate; Congenital Abnormalities; Diet; Female; Fetus; Hexobarb | 1985 |
Refractory status epilepticus in pregnancy. A case report.
Topics: Anticonvulsants; Diazepam; Female; Humans; Phenytoin; Pregnancy; Pregnancy Complications; Status Epi | 1985 |
Thyroid function in epileptic mothers and their infants at birth.
Topics: Anticonvulsants; Epilepsy; Female; Fetal Blood; Humans; Infant, Newborn; Phenytoin; Pregnancy; Pregn | 1985 |
Ependymoblastoma associated with prenatal exposure to diphenylhydantoin and methylphenobarbitone.
Topics: Brain Neoplasms; Child, Preschool; Ependymoma; Female; Frontal Lobe; Heterozygote; Humans; Maternal- | 1985 |
Anticonvulsant use during pregnancy.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Epilepsy; Female; Fetal Death; Humans; Phenobarbital; | 1985 |
Dosage of phenytoin during pregnancy.
Topics: Epilepsy; Female; Humans; Phenytoin; Pregnancy; Pregnancy Complications | 1985 |
[Clinical pharmacology of carbamazepine--a comparison with phenytoin].
Topics: Adult; Anticonvulsants; Carbamazepine; Child; Female; Humans; Male; Phenytoin; Pregnancy | 1985 |
Phenytoin and trimethadione: pharmacokinetics, embryotoxicity, and maternal toxicity.
Topics: Abnormalities, Drug-Induced; Animals; Embryo, Mammalian; Female; Half-Life; Humans; Infant, Newborn; | 1985 |
The water, DNA, collagen and noncollagen protein contents in embryos after maternal administration of a teratogenic dose of phenytoin.
Topics: Animals; Collagen; DNA; Embryo, Mammalian; Embryonic and Fetal Development; Female; Maternal-Fetal E | 1985 |
A theoretical and an in vitro experimental model for estimation of drug transfer through the human placenta.
Topics: Female; Humans; In Vitro Techniques; Kinetics; Maternal-Fetal Exchange; Models, Biological; Perfusio | 1985 |
Expanding physician duties and patients rights in wrongful life: Harbeson v. Parke-Davis, Inc.
Topics: Abnormalities, Drug-Induced; Adult; Female; Humans; Infant, Newborn; Male; Malpractice; Patient Advo | 1985 |
The effect of phenytoin on testosterone metabolism in vitro.
Topics: Adult; Androstenedione; Dihydrotestosterone; Disorders of Sex Development; Female; Humans; In Vitro | 1985 |
[Postnatal effects of intrauterine chemical stress].
Topics: Adolescent; Adrenal Gland Neoplasms; Adult; Dyskinesia, Drug-Induced; Failure to Thrive; Female; Fet | 1985 |
Status epilepticus in pregnancy. A case report.
Topics: Adolescent; Diazepam; Female; Humans; Infusions, Parenteral; Phenobarbital; Phenytoin; Pregnancy; Pr | 1985 |
Sister-chromatid exchange and cell replication kinetics in fetal and maternal cells after treatment with chemical teratogens.
Topics: Animals; Benzene; Bone Marrow; Cell Cycle; Cyclophosphamide; Diethylstilbestrol; Dimethyl Sulfoxide; | 1985 |
The in vivo biosynthesis of embryonic proteins after maternal administration of phenytoin in the mouse.
Topics: Animals; Embryo, Mammalian; Extremities; Female; Maternal-Fetal Exchange; Mice; Mice, Inbred A; Mole | 1985 |
The pharmacokinetics of phenytoin in perfused human placenta.
Topics: Biotransformation; Blood Proteins; Chromatography, High Pressure Liquid; Female; Fetus; Humans; In V | 1985 |
Perinatal induction of hepatic aminopyrine N-demethylase by maternal exposure to phenytoin.
Topics: Aminopyrine N-Demethylase; Animals; Animals, Newborn; Body Weight; Enzyme Induction; Female; Kinetic | 1985 |
A new estimate of the thyroxine binding globulin capacity.
Topics: Binding, Competitive; Chromatography; Contraceptives, Oral; Female; Humans; Hyperthyroidism; Hypothy | 1972 |
Congenital malformations among infants born to epileptic women.
Topics: Abnormalities, Drug-Induced; Cleft Lip; Cleft Palate; Congenital Abnormalities; England; Epilepsy; F | 1973 |
Phenytoin teratogenicity in man.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Anticonvulsants; Dose-Response Relationship, D | 1973 |
Phenytoin-associated congenital defects with Y-chromosome variant.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adult; Chromosome Aberrations; Female; Humans; | 1973 |
Cyanocabalamin and anticonvulsant-associated congenital defects.
Topics: Abnormalities, Drug-Induced; Animals; Anticonvulsants; Female; Humans; Mice; Phenytoin; Pregnancy; V | 1973 |
Letter: Chelating agents and teratogenesis.
Topics: Abnormalities, Drug-Induced; Animals; Chelating Agents; Cortisone; Female; Haplorhini; Humans; Pheny | 1973 |
Letter: Anticonvulsants and congenital abnormalities.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Anticonvulsants; Epilepsy; Female; Fingers; He | 1974 |
The assay of urinary thyroid hormones for assessing thyroid function.
Topics: Adult; Circadian Rhythm; Diagnosis, Differential; Estrogens; Female; Humans; Hyperthyroidism; Hypoth | 1974 |
[Manifestation of myotonic disturbances of muscle function under continuous intravenous drip treatment with the beta-adrenergic th 1165 a (fenoterolhydrobromide) (author's transl)].
Topics: Adrenergic beta-Agonists; Adult; Bromides; Female; Humans; Metaproterenol; Myotonic Dystrophy; Pheno | 1974 |
Clinical evaluation of a new method for the determination of serum thyroxine.
Topics: Adult; Blood; Cholesterol; Estrogens; Female; Humans; Hyperthyroidism; Hypoproteinemia; Hypothyroidi | 1966 |
Ceft palate in the offspring of female mice treated with phenytoin.
Topics: Animals; Cleft Palate; Female; Mice; Phenytoin; Pregnancy | 1969 |
Neonatal coagulation defect due to anticonvulsant drug treatment in pregnancy.
Topics: Adolescent; Adult; Anticonvulsants; Barbiturates; Blood Coagulation Disorders; Blood Coagulation Tes | 1970 |
Coagulation defect due to anticonvulsant drug treatment in pregnancy.
Topics: Adult; Blood Coagulation Disorders; Epilepsy; Female; Humans; Infant, Newborn; Infant, Newborn, Dise | 1970 |
Neonatal haemorrhage following maternal anticonvulsant therapy.
Topics: Adult; Anticonvulsants; Epilepsy; Female; Humans; Infant, Newborn; Male; Phenobarbital; Phenytoin; P | 1970 |
Determination of the binding of thyroxine to plasma proteins by competitive protein-binding analysis.
Topics: Barbiturates; Binding Sites; Binding, Competitive; Buffers; Chromatography, Gel; Dialysis; Evaluatio | 1973 |
The metabolism of 5,5-diphenylhydantoin (DPH) in nonpregnant and pregnant Rhesus monkeys.
Topics: Animals; Autoradiography; Carbon Isotopes; Chromatography, Thin Layer; Female; Haplorhini; Hydrolysi | 1973 |
Digital hypoplasia and anticonvulsants during gestation: a teratogenic syndrome?
Topics: Abnormalities, Drug-Induced; Epilepsy, Tonic-Clonic; Female; Fingers; Hand; Humans; Infant, Newborn; | 1974 |
[Haemorrhagic diathesis in a newborn child of a mother on anti-epileptic medication (author's transl)].
Topics: Adult; Anticonvulsants; Drug Therapy, Combination; Epilepsy, Tonic-Clonic; Female; Hemostatics; Huma | 1974 |
Folic acid and dilantin antagonism in pregnancy.
Topics: Adult; Chromatography, Gas; Drug Antagonism; Epilepsy; Epilepsy, Absence; Epilepsy, Tonic-Clonic; Fe | 1974 |
Evaluation of thyroid status with "effective thyroxine ratio" (E.T.R.).
Topics: Adolescent; Adult; Aged; Aspirin; Depression, Chemical; Estrogens; Evaluation Studies as Topic; Fema | 1974 |
The dysmorphogenic potential of phenytoin: experimental observations.
Topics: Abnormalities, Drug-Induced; Animals; Epilepsy; Female; Fetus; Folic Acid; Folic Acid Deficiency; Ha | 1974 |
Transplacental chemical carcinogenesis in man.
Topics: Abnormalities, Drug-Induced; Aminopterin; Animals; Chloramphenicol; Diethylstilbestrol; Female; Foll | 1971 |
[Epilepsy and perinatal injury].
Topics: Adolescent; Adrenocorticotropic Hormone; Barbiturates; Birth Injuries; Brain Diseases; Cerebral Hemo | 1973 |
Retarded growth of rats by anticonvulsant drugs.
Topics: Animals; Body Weight; Cholecalciferol; Dwarfism; Female; Growth; Maternal-Fetal Exchange; Pentobarbi | 1974 |
Neonatal effects of maternal treatment with the anticonvulsant drug diphenylhydantoin.
Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Blood Coagulation Disorders; Epilepsy; Female; Human | 1971 |
Epilepsy.
Topics: Adult; Child; Epilepsies, Partial; Epilepsy; Epilepsy, Absence; Epilepsy, Temporal Lobe; Epilepsy, T | 1969 |
[Gynecological aspects of thrombocytopenia].
Topics: Adult; Analgesics; Anti-Bacterial Agents; Anti-Inflammatory Agents; Antineoplastic Agents; Contracep | 1972 |
[Antiepileptic drugs and congenital malformations. Interaction between antiepileptic drugs and contraceptives?].
Topics: Abnormalities, Drug-Induced; Contraceptives, Oral; Drug Interactions; Epilepsy; Female; Humans; Infa | 1974 |
Do anticonvulsants have a teratogenic effect?
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Child, Preschool; Cleft Lip; Cleft Palate; Congenital | 1974 |
The pattogenesis of submucous cleft palate.
Topics: Abnormalities, Drug-Induced; Animals; Cell Differentiation; Cleft Palate; Disease Models, Animal; Fe | 1974 |
Comparative embryotoxicity of diphenyldantoin and some of its metabolites in mice.
Topics: Abnormalities, Drug-Induced; Animals; Diphenylacetic Acids; Dose-Response Relationship, Drug; Embryo | 1974 |
Updating the genetics of cleft lip and palate.
Topics: Cleft Lip; Cleft Palate; Environmental Exposure; Face; Female; Humans; Male; Maternal Age; Nervous S | 1974 |
Iatrogenic nutritional effects of anticonvulsants.
Topics: Adolescent; Adult; Anticonvulsants; Blood Coagulation Disorders; Bone Diseases; Child; Child, Presch | 1974 |
Phenobarbital-induced coagulation defects in cats.
Topics: Alanine Transaminase; Animals; Animals, Newborn; Blood Coagulation; Blood Coagulation Disorders; Cat | 1974 |
Sympodia.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Abnormalities, Severe Teratoid; Autopsy; Epile | 1974 |
Letter: Digital hypoplasia and anticonvulsants during pregnancy.
Topics: Anticonvulsants; Barbiturates; Carbamazepine; Diazepam; Female; Fingers; Maternal-Fetal Exchange; Ph | 1974 |
Effects of age, sex, obesity, and pregnancy on plasma diphenylhydantoin levels.
Topics: Adolescent; Adult; Age Factors; Analysis of Variance; Chromatography, Gas; Dose-Response Relationshi | 1974 |
Urinary excretion of diphenylhydantoin metabolites in newborn infants.
Topics: Chromatography, Gas; Epilepsy; Female; Half-Life; Humans; Infant, Newborn; Maternal-Fetal Exchange; | 1974 |
Anticonvulsants and pregnancy.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Epilepsy; Female; Humans; Phenytoin; Pregnancy; Pregna | 1973 |
Infratentorial gas encephalogram and mental retardation.
Topics: Abnormalities, Drug-Induced; Cerebellum; Female; Humans; Infant, Newborn; Intellectual Disability; M | 1972 |
Oral medicine for the dental practitioner. 8. Oral symptoms in generalised disease.
Topics: Anemia, Hypochromic; Anemia, Pernicious; Anti-Bacterial Agents; Diabetes Complications; Female; Ging | 1974 |
Further studies on effect of diphenylhydantoin sodium on oro-facial tissues in offspring of female mice.
Topics: Animals; Animals, Newborn; Cleft Palate; Dose-Response Relationship, Drug; Female; Hypertrophy; Mice | 1972 |
The modifying effect of folinic acid on diphenylhydantoin-induced teratogenicity in mice.
Topics: Abnormalities, Drug-Induced; Animals; Cleft Palate; Female; Fetal Death; Fetus; Leucovorin; Mice; Or | 1973 |
A medical and social survey of 231 children with seizures.
Topics: Adolescent; Attitude to Health; Child; Child Behavior Disorders; Child, Preschool; Electroencephalog | 1972 |
The distribution of 5,5-diphenylhydantoin (DPH) and its metabolites in maternal anf fetal Rhesus monkey tissues.
Topics: Animals; Blood-Brain Barrier; Female; Fetus; Haplorhini; Liver; Macaca; Maternal-Fetal Exchange; Myo | 1972 |
[Arrhythmia in pregnancy].
Topics: Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Female; Humans; Isoproterenol; Lidocaine; Phenytoin; P | 1972 |
Potential hazards of hydantoin use.
Topics: Epilepsy; Female; Humans; Immunity, Cellular; Immunoglobulins; Immunologic Deficiency Syndromes; Phe | 1972 |
Coagulation defects caused by diphenylhydantoin.
Topics: Animals; Blood Coagulation Disorders; Blood Coagulation Factors; Cats; Factor IX; Factor V; Factor V | 1972 |
[Epilepsy and pregnancy].
Topics: Abortion, Spontaneous; Anticonvulsants; Birth Weight; Epilepsy; Female; Humans; Infant, Newborn; Inf | 1973 |
Epilepsy and pregnancy: a report from the Oxford Record Linkage Study.
Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Age Factors; Child; Congenital Abnormalities; Drug S | 1973 |
Use of stable isotopes in measuring low concentrations of drugs and drug metabolites by GC-MS-COM procedures.
Topics: Amniotic Fluid; Barbiturates; Caffeine; Carbon Isotopes; Child; Chromatography, Gas; Colostrum; Comp | 1973 |
Non-Gaussian distribution of serum thyroxine levels for euthyroid population.
Topics: Adolescent; Adult; Aged; Androgens; Binding, Competitive; Child; Child, Preschool; Estrogens; Female | 1973 |
Serum folic acid activity (L. casei) in Sephadex gel chromatography.
Topics: Albumins; Anemia, Pernicious; Chromatography; Dextrans; Female; Folic Acid; Humans; Macroglobulins; | 1973 |
Diphenylhydantoin half-life in man and its inhibition by phenylbutazone: the role of genetic factors.
Topics: Adult; Carbon Isotopes; Female; Genetics, Medical; Half-Life; Humans; Male; Phenylbutazone; Phenytoi | 1973 |
Diphenylhydantoin and selected congenital malformations.
Topics: Abnormalities, Drug-Induced; Adult; Birth Weight; Congenital Abnormalities; Epilepsy; Female; Fetus; | 1973 |
Editorial: Teratogenesis and antiepileptic drugs.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Cleft Lip; Cleft Palate; Congenital Abnormalities; Epi | 1973 |
[Teratogenic effects of phenytoin and other antiepileptic agents].
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Female; Humans; Phenytoin; Pregnancy | 1973 |
The teratological effects of anticonvulsants and the effects on pregnancy and birth.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Carbamazepine; Child; Cleft Lip; Cleft Palate; Cyclohe | 1973 |
Lymphocytosis in the first-trimester placenta of a mother taking diphenylhydantoin.
Topics: Abortion, Induced; Adult; Epilepsy; Female; Humans; Lymphocytosis; Phenytoin; Placenta; Placenta Dis | 1973 |
[Folic acid and folate values in plasma and whole blood].
Topics: Acute Disease; Barbiturates; Contraceptives, Oral; Epilepsy; Ethanol; Female; Folic Acid; Folic Acid | 1973 |
Plasma disappearance of transplacentally transferred diphenylhydantoin in the newborn studied by mass fragmentography.
Topics: Adult; Deuterium; Epilepsy; Female; Half-Life; Humans; Infant, Newborn; Kinetics; Male; Mass Spectro | 1974 |
[Letter: Diphenylhydantoins and teratogenic hazards].
Topics: Abnormalities, Drug-Induced; Epilepsy; Female; Humans; Phenytoin; Pregnancy; Pregnancy Complications | 1974 |
[Letter: Teratogenic hazards in antiepileptic therapy].
Topics: Abnormalities, Drug-Induced; Carbamazepine; Epilepsy; Female; Humans; Phenobarbital; Phenytoin; Preg | 1974 |
Plasma protein binding of diphenylhydantoin. Effects of sex hormones, renal and hepatic disease.
Topics: Adult; Age Factors; Aged; Bilirubin; Blood Proteins; Contraceptives, Oral; Female; Gonadal Steroid H | 1974 |
Infants exposed in utero to antiepileptic drugs. A prospective study.
Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Amitriptyline; Amniotic Fluid; Anticonvulsants; Chro | 1974 |
Letter: Anticonvulsant drugs and congenital abnormalities.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Epilepsy; Female; Fetus; Fingers; Humans; Infant; Nail | 1974 |
Placental transfer of diphenylhydantoin: effects of species, gestational age, and route of administration.
Topics: Animals; Biological Transport; Brain Chemistry; Carbon Radioisotopes; Cricetinae; Female; Fetus; Ges | 1974 |
Editorial: Congenital malformations and antiepileptic drugs.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Epilepsy; Female; Humans; Infant, Newborn; Maternal-Fe | 1974 |
Estimation of thyroxine binding protein capacities using a non-electrophoretic technique.
Topics: Barbiturates; Blood Protein Electrophoresis; Buffers; Cholestasis; Female; Humans; Multiple Myeloma; | 1969 |
Placental transfer and neonatal elimination of diphenylhydantoin.
Topics: Abnormalities, Drug-Induced; Cleft Lip; Cleft Palate; Epilepsy; Female; Humans; Infant, Newborn; Lon | 1971 |
[Action of diphenylhydantoin on chromosomes].
Topics: Animals; Bone Marrow; Bone Marrow Cells; Chromosomes; Colchicine; Culture Techniques; Embryo, Mammal | 1971 |
Distribution and metabolism of diphenyl-hydantoin- 14 C in fetal and maternal tissues of the pregnant mouse.
Topics: Adrenal Glands; Animals; Autoradiography; Brain; Carbon Isotopes; Chromatography, Thin Layer; Female | 1972 |
Unplanned pregnancy in an epileptic.
Topics: Amenorrhea; Contraceptives, Oral; Epilepsy; Ethinyl Estradiol; Female; Folic Acid; Gluconates; Human | 1972 |
The hazard of neurotropic drugs in the fertile years.
Topics: Abnormalities, Drug-Induced; Dextropropoxyphene; Diazepam; Female; Humans; Meprobamate; Phenytoin; P | 1972 |
Phocomelia.
Topics: Abnormalities, Drug-Induced; Ectromelia; Female; Humans; Infant, Newborn; Maternal-Fetal Exchange; P | 1972 |
Diphenylhydantoin teratogenicity in rats.
Topics: Abnormalities, Drug-Induced; Animals; Body Weight; Bone and Bones; Cleft Palate; Female; Fetal Death | 1972 |
Placental transfer of diphenylhydantoin in the goat.
Topics: Amniotic Fluid; Animals; Antipyrine; Blood Chemical Analysis; Blood Proteins; Chromatography, Gas; E | 1972 |
Dilantin and hare-lip.
Topics: Abnormalities, Drug-Induced; Cleft Lip; Female; Humans; Infant, Newborn; Phenytoin; Pregnancy | 1972 |
Drugs and folic acid utilization.
Topics: Anemia, Macrocytic; Contraceptives, Oral; Female; Folic Acid; Folic Acid Deficiency; Glutamates; Hum | 1971 |
Plasma protein binding of diphenylhydantoin in normal and hyperbilirubinemic infants.
Topics: Bilirubin; Binding Sites; Blood Proteins; Carbon Isotopes; Desipramine; Female; Filtration; Humans; | 1971 |
[Changes of drug effects caused by their metabolism in the liver].
Topics: Aminopyrine; Animals; Cytochromes; Dogs; Drug Stability; Endoplasmic Reticulum; Female; Fetus; Hexob | 1971 |
Effects of anticonvulsant drugs on chromosomes.
Topics: Animals; Bone Marrow; Bone Marrow Cells; Chromosome Aberrations; Embryo, Mammalian; Female; Fertilit | 1971 |
Induction of premature menstruation with catatoxic steroids.
Topics: Abortion, Therapeutic; Adult; Biotransformation; Body Temperature; Contraceptives, Oral; Endometrium | 1971 |
Effects of phenobarbital or SKF 525A pretreatment on diphenylhydantoin disposition in pregnant mice.
Topics: Abnormalities, Drug-Induced; Adipose Tissue; Amniotic Fluid; Animals; Brain Chemistry; Carbon Isotop | 1971 |
Age differences in drug binding by plasma proteins: studies on human foetuses, neonates and adults.
Topics: Adult; Age Factors; Aging; Ampicillin; Azides; Bilirubin; Blood Proteins; Dialysis; Female; Fetus; F | 1971 |
A comparison of the binding of drugs to adult and cord plasma.
Topics: Blood; Blood Proteins; Carbon Isotopes; Cephaloglycin; Cephalothin; Chromatography, Thin Layer; Dial | 1971 |
Relation of dosage and time of administration of diphenylhydantoin to its teratogenic effect in mice.
Topics: Abnormalities, Drug-Induced; Animals; Body Weight; Cleft Lip; Cleft Palate; Embryonic and Fetal Deve | 1969 |
The distribution and metabolism of Dilantin in non-pregnant, pregnant and fetal rats.
Topics: Administration, Oral; Anemia, Macrocytic; Animals; Brain Chemistry; Female; Fetal Diseases; Fetus; K | 1970 |
Passage of diphenylhydantoin across the placenta.
Topics: Adult; Epilepsy; Female; Humans; Infant, Newborn; Male; Maternal-Fetal Exchange; Phenytoin; Placenta | 1970 |
Effect of phenobarbital and SKF 525A pretreatment on diphenylhydantoin teratogenicity in mice.
Topics: Abnormalities, Drug-Induced; Animals; Body Weight; Depression, Chemical; Drug Synergism; Female; Fet | 1970 |
Anticonvulsants and hemorrhagic diseases of the newborn infant.
Topics: Epilepsy; Female; Humans; Infant, Newborn; Phenytoin; Pregnancy; Pregnancy Complications; Vitamin K | 1970 |
P henobarbital-Dilantin treatment of the intrauterine patient.
Topics: Enzyme Induction; Epilepsy; Erythroblastosis, Fetal; Female; Fetal Diseases; Humans; Infant, Newborn | 1970 |
Drugs and the liver.
Topics: Bilirubin; Cushing Syndrome; DDT; Enzyme Induction; Ethanol; Female; Humans; Hyperbilirubinemia; Inf | 1970 |
Chronic diphenylhydantoin intoxication in the albino rat during pregnancy.
Topics: Animals; Animals, Newborn; Brain Chemistry; Cerebellum; Female; Fetus; Liver; Maternal-Fetal Exchang | 1970 |
Diphenylhydantoin: placental transport, fetal localization, neonatal metabolism, and possible teratogenic effects.
Topics: Abnormalities, Drug-Induced; Administration, Oral; Adrenal Glands; Animals; Biological Transport; Br | 1971 |
Diphenylhydantoin intoxication during pregnancy. A chemical study of drug distribution in the albino rat.
Topics: Animals; Animals, Newborn; Brain Chemistry; Brain Stem; Cerebellum; Cerebral Cortex; Female; Liver; | 1971 |
Maternal folate deficiency and pregnancy wastage. IV. Effects of folic acid supplements, anticonvulsants, and oral contraceptives.
Topics: Abnormalities, Drug-Induced; Abortion, Spontaneous; Anemia, Macrocytic; Anemia, Sickle Cell; Anemia, | 1971 |
Diphenylhydantoin: effect on the chromosomes of human leukocytes.
Topics: Abnormalities, Drug-Induced; Adult; Chromosome Aberrations; Chromosome Disorders; Chromosomes; Cultu | 1971 |
[Congenital abnormalities, cleft lip and cleft palate in particular, in children of epileptic mothers].
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adult; Cleft Lip; Cleft Palate; Epilepsy; Fema | 1971 |
Teratogenic effects of diphenylhydantoin in Swiss-Webster and A-J mice.
Topics: Abnormalities, Drug-Induced; Animals; Cleft Lip; Cleft Palate; Female; Femur; Fetus; Fibula; Humerus | 1968 |
Neonatal hypocalcemia.
Topics: Female; Humans; Hypocalcemia; Infant, Newborn; Maternal-Fetal Exchange; Phenytoin; Pregnancy; Tetany | 1968 |
[On the problem of the treatment of cerebral epilepsy during pregnancy, labor and puerperium].
Topics: Anticonvulsants; Delivery, Obstetric; Epilepsy; Female; Humans; Obstetric Labor Complications; Pheno | 1968 |
The effect of 5,5-diphenylhydantoin on the rat uterus and its fetuses.
Topics: Animals; Body Weight; Collagen; Female; Fetal Death; Fetus; Hydroxyproline; Nitrogen; Organ Size; Ph | 1968 |
Transplacental effects of drugs in mice.
Topics: Abnormalities, Drug-Induced; Animals; Female; Fetal Death; Male; Maternal-Fetal Exchange; Methylcell | 1965 |
Teratogenic effects of diphenylhydantoin sodium.
Topics: Abnormalities, Drug-Induced; Animals; Cleft Lip; Cleft Palate; Female; Mice; Phenytoin; Pregnancy; P | 1966 |