phenytoin has been researched along with Polyneuropathies in 8 studies
Polyneuropathies: Diseases of multiple peripheral nerves simultaneously. Polyneuropathies usually are characterized by symmetrical, bilateral distal motor and sensory impairment with a graded increase in severity distally. The pathological processes affecting peripheral nerves include degeneration of the axon, myelin or both. The various forms of polyneuropathy are categorized by the type of nerve affected (e.g., sensory, motor, or autonomic), by the distribution of nerve injury (e.g., distal vs. proximal), by nerve component primarily affected (e.g., demyelinating vs. axonal), by etiology, or by pattern of inheritance.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Oral neuropathic pain medication often has insufficient pain relief and side effects." | 3.11 | Enriched enrollment randomized double-blind placebo-controlled cross-over trial with phenytoin cream in painful chronic idiopathic axonal polyneuropathy (EPHENE): a study protocol. ( Keppel Hesselink, JM; Kopsky, DJ; Notermans, NC; van Eijk, RPA; Vrancken, AFJE; Warendorf, JK, 2022) |
| "During this treatment a severe mainly motor polyneuropathy occurred acutely which was more pronounced in the distal parts of the legs, and cerebellar symptoms were noted at the same time." | 1.25 | [Acute polyneuropathy caused by diphenylhydantoin intoxication (author's transl)]. ( Bajc, O; Meienberg, O, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (75.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (12.50) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (12.50) | 2.80 |
| Authors | Studies |
|---|---|
| Kopsky, DJ | 1 |
| van Eijk, RPA | 1 |
| Warendorf, JK | 1 |
| Keppel Hesselink, JM | 1 |
| Notermans, NC | 1 |
| Vrancken, AFJE | 1 |
| Toth, C | 1 |
| Kotecha, SA | 1 |
| Vasilescu, C | 1 |
| Florescu, A | 1 |
| Wessely, P | 1 |
| Mayr, N | 1 |
| Binder, H | 1 |
| Klingler, D | 1 |
| Meienberg, O | 1 |
| Bajc, O | 1 |
| Bauer, G | 1 |
| Nowak, H | 1 |
| Polaczek, R | 1 |
| Igata, A | 1 |
| Evans, DA | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Enrichment Randomized Double-blind, Placebo-controlled Cross-over Trial With PHEnytoin Cream in Patients With Painful Chronic Idiopathic Axonal polyNEuropathy[NCT04647877] | Phase 2/Phase 3 | 81 participants (Actual) | Interventional | 2020-09-17 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for phenytoin and Polyneuropathies
| Article | Year |
|---|---|
[Ataxia associated with infections and toxicosis].
Topics: Abdomen; Adult; Animals; Ataxia; Cerebellar Ataxia; Cerebrovascular Disorders; Demyelinating Disease | 1971 |
Genetic factors in drug therapy.
Topics: Adolescent; Aged; Alcohol Oxidoreductases; Animals; Anticoagulants; Child; Female; Glaucoma; Humans; | 1969 |
1 trial available for phenytoin and Polyneuropathies
| Article | Year |
|---|---|
Enriched enrollment randomized double-blind placebo-controlled cross-over trial with phenytoin cream in painful chronic idiopathic axonal polyneuropathy (EPHENE): a study protocol.
Topics: Cross-Over Studies; Double-Blind Method; Humans; Neuralgia; Phenytoin; Polyneuropathies; Quality of | 2022 |
5 other studies available for phenytoin and Polyneuropathies
| Article | Year |
|---|---|
Prolonged and excessive phenytoin therapy leading to a severe and partially reversible polyneuropathy.
Topics: Anticonvulsants; Humans; Male; Middle Aged; Phenytoin; Polyneuropathies; Seizures; Syncope | 2004 |
Peripheral neuropathy with a syndrome of continuous motor unit activity.
Topics: Alcoholism; Electromyography; Humans; Hypesthesia; Male; Middle Aged; Motor Neurons; Neural Conducti | 1982 |
[Neurological signs in diphenylhydantoin intoxication (case reports and review) (author's transl)].
Topics: Adult; Biopsy; Cerebellar Ataxia; Electroencephalography; Epilepsy; Evoked Potentials; Female; Human | 1981 |
[Acute polyneuropathy caused by diphenylhydantoin intoxication (author's transl)].
Topics: Acute Disease; Adult; Cerebellar Diseases; Epilepsy, Tonic-Clonic; Humans; Male; Peripheral Nervous | 1975 |
[Polyneuropathy due to diphenylhydantoin overdosage].
Topics: Adult; Epilepsy; Humans; Long-Term Care; Male; Paralysis; Phenytoin; Polyneuropathies | 1974 |