phenytoin has been researched along with Peripheral Nervous System Diseases in 52 studies
Peripheral Nervous System Diseases: Diseases of the peripheral nerves external to the brain and spinal cord, which includes diseases of the nerve roots, ganglia, plexi, autonomic nerves, sensory nerves, and motor nerves.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Reversible dystonia may occasionally be precipitated by phenytoin or carbamazepine; asterixis by phenytoin, barbiturates or carbamazepine; and, more commonly, tremor by valproate." | 4.77 | Adverse neuropsychiatric effects of anticonvulsant drugs. ( Reynolds, EH; Trimble, MR, 1985) |
| "Phenytoin sodium intoxication of subacute onset may occur in cases of nonepileptic patients who receive phenytoin for suppression of cardiac arrhythmias." | 3.66 | Subacute phenytoin intoxication syndrome. ( Tindall, RS; Willerson, J, 1978) |
| "Classically, trigeminal neuralgia has been described as a paroxysmal, lancinating, knifelike pain which is limited to the anatomic pathways of the fifth cranial nerve." | 2.36 | Trigeminal neuralgia: an overview. ( Bayer, DB; Stenger, TG, 1979) |
| " Long-term use of phenytoin can lead to axonal shrinkage and random clusters of nerve demyelination [1]." | 1.43 | Lacking the 'protective label' of diabetes: Phenytoin-induced distal symmetrical peripheral neuropathy. A clinical case report. ( Mahon, AM, 2016) |
| " Hill slope coefficients for the tested anticonvulsants indicate that the dose-response curve was less steep for gabapentin than for phenytoin, carbamazepine and ethosuximide." | 1.32 | Potent analgesic effects of anticonvulsants on peripheral thermal nociception in rats. ( Jevtovic-Todorovic, V; Rastogi, AJ; Todorovic, SM, 2003) |
| " We consider his cerebellar symptoms and peripheral neuropathy could be attributable to the long-term use of multiple anticonvulsants, i." | 1.29 | [Lennox syndrome associated with severe cerebellar dysfunction and peripheral neuropathy]. ( Kubota, M; Nagata, J, 1993) |
| " We found a noticeable relationship between conduction velocity slowing and daily dosage for CBZ only." | 1.27 | Anticonvulsant therapy and its possible consequences on peripheral nervous system: a neurographic study. ( Faedda, MT; Geraldini, C; Sideri, G, 1984) |
| "Phenytoin has been implicated as a causative agent in peripheral neuropathy, although structural changes in nerve have not been characterized." | 1.27 | Phenytoin neuropathy: structural changes in the sural nerve. ( Griggs, RC; Mendell, JR; Ramirez, JA; Warmolts, JR, 1986) |
| " A significant correlation was noted between the total dosage and duration of therapy with PHT and the reduction of motor conduction velocity in the posterior tibial nerve." | 1.26 | Peripheral neuropathy in children on long-term phenytoin therapy. ( Mochizuki, Y; Motomura, T; Ohkubo, H; Suyehiro, Y; Tanizawa, A, 1981) |
| "Hirsutism was rare in black patients." | 1.26 | Effects of diphenylhydantoin in 41 epileptics institutionalized since childhood. ( Herberg, KP, 1977) |
| "During this treatment a severe mainly motor polyneuropathy occurred acutely which was more pronounced in the distal parts of the legs, and cerebellar symptoms were noted at the same time." | 1.25 | [Acute polyneuropathy caused by diphenylhydantoin intoxication (author's transl)]. ( Bajc, O; Meienberg, O, 1975) |
| "In patients with peripheral neuropathies it was often possible to obtain nerve velocities with signal amplitudes as low as 0·1 μV and these were often slower than those obtained from the normal subjects." | 1.25 | Sensory conduction in peroneal and posterior tibial nerves using averaging techniques. ( Lovelace, RE; Myers, SJ; Zablow, L, 1973) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 40 (76.92) | 18.7374 |
| 1990's | 6 (11.54) | 18.2507 |
| 2000's | 4 (7.69) | 29.6817 |
| 2010's | 2 (3.85) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Yang, J | 1 |
| Gharagozloo, P | 1 |
| Yao, J | 1 |
| Ilyin, VI | 1 |
| Carter, RB | 1 |
| Nguyen, P | 1 |
| Robledo, S | 1 |
| Woodward, RM | 1 |
| Hogenkamp, DJ | 1 |
| Yogeeswari, P | 1 |
| Ragavendran, JV | 1 |
| Sriram, D | 1 |
| Nageswari, Y | 1 |
| Kavya, R | 1 |
| Sreevatsan, N | 1 |
| Vanitha, K | 1 |
| Stables, J | 1 |
| Mahon, AM | 1 |
| Matsumoto, H | 1 |
| Ugawa, Y | 1 |
| Todorovic, SM | 1 |
| Rastogi, AJ | 1 |
| Jevtovic-Todorovic, V | 1 |
| ROBERTS, HJ | 1 |
| Oki, Y | 1 |
| Koike, H | 1 |
| Sobue, G | 1 |
| Geraldini, C | 1 |
| Faedda, MT | 1 |
| Sideri, G | 1 |
| Wasserman, TH | 1 |
| Phillips, TL | 1 |
| Van Raalte, G | 1 |
| Urtasun, R | 1 |
| Partington, J | 1 |
| Koziol, D | 1 |
| Schwade, JG | 1 |
| Gangji, D | 1 |
| Strong, JM | 1 |
| Walker, MD | 1 |
| Strike, TA | 1 |
| Uchigata, M | 1 |
| Nozawa, T | 1 |
| Shiozawa, R | 1 |
| Tanabe, H | 1 |
| Swift, TR | 1 |
| Gross, JA | 1 |
| Ward, LC | 1 |
| Crout, BO | 1 |
| So, EL | 1 |
| Penry, JK | 1 |
| Mochizuki, Y | 1 |
| Suyehiro, Y | 1 |
| Tanizawa, A | 1 |
| Ohkubo, H | 1 |
| Motomura, T | 1 |
| Shorvon, SD | 1 |
| Reynolds, EH | 3 |
| Bahemuka, M | 1 |
| Wainaina, CM | 1 |
| Perini, M | 1 |
| Ghezzi, A | 1 |
| Basso, PF | 1 |
| Montanini, R | 1 |
| Kubota, M | 1 |
| Nagata, J | 1 |
| Yoshikawa, H | 1 |
| Abe, T | 1 |
| Oda, Y | 1 |
| Ziegler, DK | 1 |
| Meienberg, O | 1 |
| Bajc, O | 1 |
| Chokroverty, S | 1 |
| Sayeed, ZA | 1 |
| McCarthy, D | 1 |
| Manning, N | 1 |
| Drury, M | 1 |
| Harik, SI | 1 |
| Baraka, AS | 1 |
| Tomeh, GF | 1 |
| Mire-Salman, J | 1 |
| Kronful, Z | 1 |
| Afifi, AK | 1 |
| Herberg, KP | 1 |
| Dobkin, BH | 1 |
| Tindall, RS | 1 |
| Willerson, J | 1 |
| Boldyrev, AI | 1 |
| Fleĭs, EP | 1 |
| Vaĭntrub, MIa | 1 |
| Bayer, DB | 1 |
| Stenger, TG | 1 |
| Mehrotra, TN | 1 |
| Srivastava, SS | 1 |
| Goel, VK | 1 |
| Sood, K | 1 |
| Singh, VS | 1 |
| Jain, AK | 1 |
| Skelton, WP | 1 |
| Skelton, NK | 1 |
| Hahn, AF | 1 |
| Parkes, AW | 1 |
| Bolton, CF | 1 |
| Stewart, SA | 1 |
| Trimble, MR | 1 |
| Halonen, P | 1 |
| Lang, HA | 1 |
| Nyrke, T | 1 |
| Ramirez, JA | 1 |
| Mendell, JR | 1 |
| Warmolts, JR | 1 |
| Griggs, RC | 1 |
| Horwitz, SJ | 4 |
| Klipstein, FA | 1 |
| Lovelace, RE | 4 |
| Ellenberg, M | 1 |
| Wallis, WE | 2 |
| Van Poznak, A | 1 |
| Plum, F | 2 |
| Greenberg, JO | 1 |
| Welch, LK | 1 |
| Appenzeller, O | 1 |
| Bicknell, JM | 1 |
| Gardner, AJ | 1 |
| Selhorst, JB | 1 |
| Kaufman, B | 1 |
| Cantor, FK | 1 |
| Rohmer, F | 1 |
| Collard, M | 1 |
| Warter, JM | 1 |
| Coquillat, G | 1 |
| Myers, SJ | 1 |
| Zablow, L | 1 |
| Eisen, AA | 1 |
| Woods, JF | 1 |
| Sherwin, AL | 1 |
| Encinoza, O | 1 |
5 reviews available for phenytoin and Peripheral Nervous System Diseases
| Article | Year |
|---|---|
[Adverse effects of therapeutic drugs on peripheral nervous system].
Topics: Anti-HIV Agents; Anticonvulsants; Antineoplastic Agents; Antitubercular Agents; Cisplatin; Dose-Resp | 2007 |
Adverse effects of phenytoin on peripheral nerves and neuromuscular junction: a review.
Topics: Action Potentials; Animals; Electroencephalography; Humans; Myasthenia Gravis; Neural Conduction; Ne | 1981 |
Toxicity to the nervous system of diphenylhydantoin: a review.
Topics: Adrenal Cortex Hormones; Animals; Cardiovascular Diseases; Cerebellar Ataxia; Cerebellar Diseases; C | 1978 |
Trigeminal neuralgia: an overview.
Topics: Age Factors; Aged; Anesthetics, Local; Carbamazepine; Diagnosis, Differential; Electrocoagulation; F | 1979 |
Adverse neuropsychiatric effects of anticonvulsant drugs.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Barbiturates; Benzodiazepines; Biogenic Amines; Carba | 1985 |
2 trials available for phenytoin and Peripheral Nervous System Diseases
| Article | Year |
|---|---|
Neuroleptics in painful thiamine deficiency neuropathy.
Topics: Aged; Carbamazepine; Electromyography; Humans; Male; Middle Aged; Neural Conduction; Pain; Periphera | 1991 |
Relation of abnormal folate metabolism to neuropathy developing during anticonvulsant drug therapy.
Topics: Adolescent; Adult; Anticonvulsants; Biological Assay; Child; Electrodiagnosis; Electromyography; Epi | 1968 |
45 other studies available for phenytoin and Peripheral Nervous System Diseases
| Article | Year |
|---|---|
3-(4-phenoxyphenyl)pyrazoles: a novel class of sodium channel blockers.
Topics: Analgesics; Animals; Cell Line; Humans; Male; Pain; Patch-Clamp Techniques; Peripheral Nervous Syste | 2004 |
Discovery of 4-aminobutyric acid derivatives possessing anticonvulsant and antinociceptive activities: a hybrid pharmacophore approach.
Topics: Analgesics; Animals; Anticonvulsants; Disease Models, Animal; gamma-Aminobutyric Acid; Hyperalgesia; | 2007 |
Lacking the 'protective label' of diabetes: Phenytoin-induced distal symmetrical peripheral neuropathy. A clinical case report.
Topics: Amputation, Surgical; Anticonvulsants; Epilepsy; Foot Ulcer; Gas Gangrene; Humans; Male; Middle Aged | 2016 |
[Drug induced peripheral neuropathy].
Topics: Amiodarone; Anti-Arrhythmia Agents; Anti-HIV Agents; Antibodies, Monoclonal; Anticonvulsants; Antine | 2012 |
Potent analgesic effects of anticonvulsants on peripheral thermal nociception in rats.
Topics: Acetates; Amines; Analgesics; Animals; Anticonvulsants; Calcium Channel Blockers; Carbamazepine; Cyc | 2003 |
THE SYNDROME OF NARCOLEPSY AND DIABETOGENIC (FUNCTIONAL) HYPERINSULINISM. OBSERVATIONS ON 190 PATIENTS, WITH EMPHASIS UPON ITS RELATIONSHIP TO OBESITY, DIABETES MELLITUS AND CEREBRAL DYSRHYTHMIAS.
Topics: Adolescent; Alcoholism; Arrhythmias, Cardiac; Brain; Diabetes Mellitus; Diet; Diet, Reducing; Electr | 1963 |
Anticonvulsant therapy and its possible consequences on peripheral nervous system: a neurographic study.
Topics: Anticonvulsants; Carbamazepine; Epilepsy; Humans; Neural Conduction; Peripheral Nerves; Peripheral N | 1984 |
The neurotoxicity of misonidazole: potential modifying role of phenytoin sodium and dexamethasone.
Topics: Central Nervous System Diseases; Dexamethasone; Drug Interactions; Half-Life; Humans; Misonidazole; | 1980 |
Misonidazole peripheral neuropathy: its relationship to plasma concentration and other drugs.
Topics: Adrenal Cortex Hormones; Barbiturates; Brain Neoplasms; Drug Interactions; Female; Glioma; Half-Life | 1980 |
Side effects of antiepileptic drugs: a peripheral neuropathy due to diphenylhydantoin (DPH) intoxication.
Topics: Adolescent; Adult; Aged; Electromyography; Epilepsy; Female; Humans; Male; Middle Aged; Peripheral N | 1980 |
Peripheral neuropathy in epileptic patients.
Topics: Epilepsy; H-Reflex; Humans; Neural Conduction; Peripheral Nervous System Diseases; Peroneal Nerve; P | 1981 |
Peripheral neuropathy in children on long-term phenytoin therapy.
Topics: Adolescent; Child; Dose-Response Relationship, Drug; Epilepsy; Female; Humans; Long-Term Care; Male; | 1981 |
Peripheral neuropathy in epileptics.
Topics: Animals; Epilepsy; Humans; Peripheral Nervous System Diseases; Phenytoin; Rats | 1982 |
Anticonvulsant peripheral neuropathy: a clinical and electrophysiological study of patients on single drug treatment with phenytoin, carbamazepine or barbiturates.
Topics: Adolescent; Adult; Aged; Barbiturates; Carbamazepine; Evoked Potentials, Somatosensory; Humans; Medi | 1982 |
Peripheral nerve damage in epileptic patients treated with phenytoin.
Topics: Adolescent; Adult; Epilepsy; Female; Humans; Male; Middle Aged; Peripheral Nervous System Diseases; | 1983 |
Association of neuromyotonia with peripheral neuropathy, myasthenia gravis and thymoma: a case report.
Topics: Autoantibodies; DNA; Electromyography; Electrophysiology; Humans; Male; Middle Aged; Myasthenia Grav | 1994 |
[Lennox syndrome associated with severe cerebellar dysfunction and peripheral neuropathy].
Topics: Adult; Anticonvulsants; Brain; Cerebellar Ataxia; Drug Therapy, Combination; Epilepsy, Generalized; | 1993 |
Extremely acute phenytoin-induced peripheral neuropathy.
Topics: Acute Disease; Adolescent; Anticonvulsants; Epilepsy, Frontal Lobe; Female; Humans; Peripheral Nervo | 1999 |
[Acute polyneuropathy caused by diphenylhydantoin intoxication (author's transl)].
Topics: Acute Disease; Adult; Cerebellar Diseases; Epilepsy, Tonic-Clonic; Humans; Male; Peripheral Nervous | 1975 |
Motor nerve conduction study in patients on diphenylhydantoin therapy.
Topics: Adolescent; Adult; Epilepsy; Folic Acid; Humans; Male; Middle Aged; Motor Neurons; Neural Conduction | 1975 |
Hyperparathyroidism, osteomalacia and peripheral neuropathy in a patient on anticonvulsant therapy.
Topics: Anticonvulsants; Female; Humans; Hyperparathyroidism; Middle Aged; Osteomalacia; Peripheral Nervous | 1977 |
Autonomous peripheral nerve activity causing generalized muscle stiffness and fasciculations: report of a case with physiological, pharmacological, and morphological observations.
Topics: Adolescent; Anesthesia, General; Anesthesia, Spinal; Arm; Carbamazepine; Curare; Electromyography; H | 1976 |
Effects of diphenylhydantoin in 41 epileptics institutionalized since childhood.
Topics: Adolescent; Adult; Alkaline Phosphatase; Anemia; Central Nervous System Diseases; Child; Epilepsy; F | 1977 |
Reversible subacute peripheral neuropathy induced by phenytoin.
Topics: Adult; Epilepsy; Female; Humans; Peripheral Nervous System Diseases; Phenytoin; Reflex, Abnormal | 1977 |
Subacute phenytoin intoxication syndrome.
Topics: Arrhythmias, Cardiac; Cerebellar Diseases; Humans; Male; Mental Disorders; Middle Aged; Peripheral N | 1978 |
[Neurologic complications following medical treatment of epileptic patients].
Topics: Adolescent; Adult; Anticonvulsants; Ataxia; Benzodiazepines; Consciousness Disorders; Dysarthria; Ey | 1979 |
A study of nerve conduction velocity in patients on diphenylhydantoin therapy.
Topics: Action Potentials; Epilepsy; Humans; Motor Neurons; Neural Conduction; Neurons, Afferent; Peripheral | 1992 |
Neuromyotonia in hereditary motor neuropathy.
Topics: Adolescent; Anti-Arrhythmia Agents; Carbamazepine; Child; Electromyography; Female; Humans; Lidocain | 1991 |
Quantitative vibration perception thresholds in patients under prolonged antiepileptic treatment.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Carbamazepine; Child; Drug Therapy, Combination; Female; H | 1985 |
Phenytoin neuropathy: structural changes in the sural nerve.
Topics: Atrophy; Axons; Electrodiagnosis; Humans; Male; Microscopy, Electron; Middle Aged; Peripheral Nerves | 1986 |
Peripheral neuropathy in long-term diphenylhydantoin therapy.
Topics: Adolescent; Adult; Child; Electromyography; Electrophysiology; Epilepsy; Humans; Middle Aged; Muscle | 1968 |
Treatment of diabetic neuropathy with diphenylhydantoin.
Topics: Aged; Diabetic Neuropathies; Female; Humans; Male; Middle Aged; Peripheral Nervous System Diseases; | 1968 |
Generalized muscular stiffness, fasciculations, and myokymia of peripheral nerve origin.
Topics: Adult; Basal Metabolism; Biopsy; Diazepam; Electromyography; Humans; Male; Muscular Diseases; Myoclo | 1970 |
Continuous fasciculations, myokymia and muscle contraction due to peripheral nerve disease.
Topics: Adult; Axons; Contracture; Electromyography; Extremities; Female; Humans; Male; Muscle Contraction; | 1969 |
Peripheral neuropathy in long-term diphenylhydantoin therapy.
Topics: Adult; Aged; Epilepsy; Female; Humans; Male; Middle Aged; Neuritis; Neurologic Examination; Peripher | 1967 |
The neurological effects of methyl bromide poisoning.
Topics: Adult; Amobarbital; Brain Diseases; Bromine; Cerebellar Ataxia; Diazepam; Dimercaprol; Electroenceph | 1971 |
Peripheral neuropathy with myokymia, sustained muscular contraction, and continuous motor unit activity.
Topics: Action Potentials; Adult; Calcium; Decamethonium Compounds; Demyelinating Diseases; Edrophonium; Ele | 1972 |
Neuropathy after alcohol withdrawal.
Topics: Adult; Alcoholism; Female; Folic Acid; Humans; Male; Middle Aged; Peripheral Nervous System Diseases | 1972 |
Diphenylhydantoin-induced cerebellar degeneration.
Topics: Adolescent; Cerebellar Ataxia; Cerebellar Diseases; Child; Electroencephalography; Epilepsy; Female; | 1972 |
Phenytoin treatment of thalamic pain.
Topics: Humans; Hypertension; Infarction; Male; Middle Aged; Neurologic Manifestations; Pain; Peripheral Ner | 1972 |
[Hydantoins and neurologic complications].
Topics: Adolescent; Brain Diseases; Cerebrospinal Fluid Proteins; Drug Hypersensitivity; Epilepsy; Humans; H | 1973 |
Sensory conduction in peroneal and posterior tibial nerves using averaging techniques.
Topics: Action Potentials; Adolescent; Adult; Aged; Computers, Analog; Diabetic Neuropathies; Electric Stimu | 1973 |
Peripheral nerve function in long-term therapy with diphenylhydantoin. A clinical and electrophysiologic correlation.
Topics: Adult; Aged; Carbamazepine; Electric Stimulation; Electromyography; Epilepsy; Ethosuximide; Evoked P | 1974 |
Nerve conduction velocity in patients on long-term diphenylhydantoin therapy.
Topics: Adolescent; Adult; Age Factors; Aged; Child; Drug Therapy, Combination; Electrodiagnosis; Epilepsy; | 1974 |
Iatrogenic disorders in epilepsy.
Topics: Adrenal Insufficiency; Anemia, Macrocytic; Animals; Anticonvulsants; Cats; Cerebellar Diseases; Drug | 1970 |