phenytoin has been researched along with Parkinson Disease in 11 studies
Parkinson Disease: A progressive, degenerative neurologic disease characterized by a TREMOR that is maximal at rest, retropulsion (i.e. a tendency to fall backwards), rigidity, stooped posture, slowness of voluntary movements, and a masklike facial expression. Pathologic features include loss of melanin containing neurons in the substantia nigra and other pigmented nuclei of the brainstem. LEWY BODIES are present in the substantia nigra and locus coeruleus but may also be found in a related condition (LEWY BODY DISEASE, DIFFUSE) characterized by dementia in combination with varying degrees of parkinsonism. (Adams et al., Principles of Neurology, 6th ed, p1059, pp1067-75)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Diphenylhydantoin (DPH) diminished the therapeutic effects of levodopa both in patients with parkinsonism and in patients with chronic manganese poisoning, as well as the levodopa-dependent dyskinesia for which the former were selected." | 3.65 | Diphenylhydantoin. Blocking of levodopa effects. ( Cotzias, GC; Mena, I; Mendez, JS; Papavasiliou, PS, 1975) |
| "The phenytoin treatment causes cerebellar defect and anemia." | 2.82 | The interplay of epilepsy with impaired mitophagy and autophagy linked dementia (MAD): A review of therapeutic approaches. ( Agrawal, M; Dhurandhar, Y; Panda, SP, 2022) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (63.64) | 18.7374 |
| 1990's | 3 (27.27) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (9.09) | 2.80 |
| Authors | Studies |
|---|---|
| Panda, SP | 1 |
| Dhurandhar, Y | 1 |
| Agrawal, M | 1 |
| Peeters, EA | 1 |
| Bloem, BR | 1 |
| Kuiper, MA | 1 |
| Vermeij, P | 1 |
| de Wolff, FA | 2 |
| Wolters, EC | 1 |
| Roos, RA | 1 |
| Ferrari, MD | 2 |
| Mendez, JS | 1 |
| Cotzias, GC | 1 |
| Mena, I | 1 |
| Papavasiliou, PS | 1 |
| Núñez, JC | 1 |
| Alonso, MD | 1 |
| Santafé, C | 1 |
| Escamilla, B | 1 |
| Clarke, BM | 1 |
| Upton, A | 1 |
| Griffin, H | 1 |
| Hudoba, P | 1 |
| Boomsma, F | 1 |
| Meerwaldt, JD | 1 |
| Man in't Veld, AJ | 1 |
| Hovestadt, A | 1 |
| Schalekamp, MA | 1 |
| Vermey, P | 1 |
| Veenema, H | 1 |
| Buruma, OJ | 1 |
| Christensen, LK | 1 |
| Skovsted, L | 1 |
| Gilland, O | 1 |
| Pakszys, W | 1 |
| Domzal, T | 1 |
2 reviews available for phenytoin and Parkinson Disease
| Article | Year |
|---|---|
The interplay of epilepsy with impaired mitophagy and autophagy linked dementia (MAD): A review of therapeutic approaches.
Topics: Anticonvulsants; Carbamazepine; Dementia; Epilepsy; Felbamate; Gabapentin; Humans; Inflammasomes; La | 2022 |
[Pathomechanism and pharmacological treatment of Parkinson's disease].
Topics: Acetylcholine; Alkaloids; Dihydroxyphenylalanine; Dopamine; Epinephrine; Histocytochemistry; Humans; | 1971 |
9 other studies available for phenytoin and Parkinson Disease
| Article | Year |
|---|---|
Phenytoin parahydroxylation is not impaired in patients with young-onset Parkinson's disease.
Topics: Administration, Oral; Adult; Age Factors; Cytochrome P-450 Enzyme System; Female; Humans; Hydroxylat | 1994 |
Diphenylhydantoin. Blocking of levodopa effects.
Topics: Adult; Aged; Dopamine; Female; Humans; Huntington Disease; Levodopa; Male; Manganese Poisoning; Midd | 1975 |
[Encephalopathy caused by phenytoin].
Topics: Aged; Brain Diseases; Female; Humans; Parkinson Disease; Phenytoin | 1992 |
Balance and cognitive impairment in two epileptic patients before and after vagal nerve stimulation.
Topics: Adult; Carbamazepine; Cognition; Electric Stimulation Therapy; Epilepsy, Temporal Lobe; Humans; Male | 1991 |
Treatment of idiopathic parkinsonism with L-dopa in the absence and presence of decarboxylase inhibitors: effects on plasma levels of L-dopa, dopa decarboxylase, catecholamines and 3-O-methyl-dopa.
Topics: Administration, Oral; Aged; Benserazide; Carboxy-Lyases; Catecholamines; Dopa Decarboxylase; Drug Co | 1989 |
Hepatic cytochrome P450 malfunction and Parkinson's disease.
Topics: Aged; Female; Humans; Liver; Male; NADPH-Ferrihemoprotein Reductase; Oxidoreductases; Parkinson Dise | 1986 |
Inhibition of drug metabolism by chloramphenicol.
Topics: Aged; Biotransformation; Carbon Isotopes; Chloramphenicol; Chromatography, Thin Layer; Dicumarol; Hu | 1969 |
[American neurology for Swedish use].
Topics: Adrenocorticotropic Hormone; Ampicillin; Brain Diseases; Cerebrovascular Disorders; Contrast Media; | 1968 |
[Effect of diphenylhydantoin on the clinical manifestations and excretion of 5-hydroxyindoloacetic acid in Parkinson's disease].
Topics: Adult; Aged; Brain; Humans; Hydroxyindoleacetic Acid; Middle Aged; Muscle Tonus; Parkinson Disease; | 1972 |