phenytoin has been researched along with Neuroblastoma in 23 studies
Neuroblastoma: A common neoplasm of early childhood arising from neural crest cells in the sympathetic nervous system, and characterized by diverse clinical behavior, ranging from spontaneous remission to rapid metastatic progression and death. This tumor is the most common intraabdominal malignancy of childhood, but it may also arise from thorax, neck, or rarely occur in the central nervous system. Histologic features include uniform round cells with hyperchromatic nuclei arranged in nests and separated by fibrovascular septa. Neuroblastomas may be associated with the opsoclonus-myoclonus syndrome. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2099-2101; Curr Opin Oncol 1998 Jan;10(1):43-51)
| Excerpt | Relevance | Reference |
|---|---|---|
| "We evaluated the causality of the association between intrauterine exposure to phenytoin and postnatal neuroblastoma using an in vitro lymphocyte toxicity assay for phenytoin-induced reactions in an unusual sibship." | 8.77 | Neuroblastoma after prenatal exposure to phenytoin: cause and effect? ( Demitrakoudis, D; Koren, G; Rieder, M; Shandling, B; Shear, NH; Sonely, M; Spielberg, SP; Weksberg, R, 1989) |
| "The action of the anticonvulsant drug phenytoin on K+ channels was investigated in neuroblastoma cells (N2A) by using the single-channel patch-clamp technique." | 7.70 | A discriminant block among K+ channel types by phenytoin in neuroblastoma cells. ( Lagostena, L; Nobile, M, 1998) |
| " The action of the anticonvulsant drug phenytoin on K+ currents was investigated in neuroblastoma cells by whole-cell voltage-clamp recording." | 7.69 | Inhibition of delayed rectifier K+ channels by phenytoin in rat neuroblastoma cells. ( Nobile, M; Vercellino, P, 1997) |
| " To characterize further the mechanism of action of lamotrigine, we have investigated the effects of this drug together with the anticonvulsant drugs phenytoin and carbamazepine on voltage-sensitive sodium channels present in N4TG1 mouse neuroblastoma clonal cells." | 7.68 | Lamotrigine, phenytoin and carbamazepine interactions on the sodium current present in N4TG1 mouse neuroblastoma cells. ( Cooper, BR; Lang, DG; Wang, CM, 1993) |
| "The interaction of phenytoin (DPH) with membrane ionic channels of cultured N1E-115 neuroblastoma cells was studied." | 7.67 | Characterization of the block of sodium channels by phenytoin in mouse neuroblastoma cells. ( Matsuki, N; Quandt, FN; Ten Eick, RE; Yeh, JZ, 1984) |
| "The action of phenytoin on the inward calcium current (ICa) was studied in cells of the clonal mouse neuroblastoma X rat glioma hybrid line 108CC5 by the suction pipette technique for internal perfusion and voltage clamp." | 7.67 | Calcium channel block by phenytoin in neuroblastoma x glioma hybrid cells. ( Bodewei, R; Hering, S; Schubert, B; Winkler, J; Wollenberger, A, 1985) |
| "The actions of diphenylhydantoin (DPH) and carbamazepine (CBZ) on sodium channels in mouse neuroblastoma cells (clone N18) were analyzed using the patch voltage clamp procedure in the whole cell configuration." | 7.67 | Voltage clamp analysis of the inhibitory actions of diphenylhydantoin and carbamazepine on voltage-sensitive sodium channels in neuroblastoma cells. ( Catterall, WA; Gonoi, T; Willow, M, 1985) |
| "Phenytoin (diphenylhydantoin) inhibits the calcium-dependent increases in guanosine 3':5'-monophosphate (cGMP) produced by high potassium depolarization and by muscarinic receptor activation in N1E-115 neuroblastoma cells." | 7.66 | Phenytoin inhibition of cyclic guanosine 3':5'-monophosphate (cGMP) accumulation in neuroblastoma cells by calcium channel blockade. ( Study, RE, 1980) |
| " The dose-response relationships for carbamazepine and diphenylhydantoin inhibition of 22Na+ flux in N18 cells are shifted 1." | 5.27 | Inhibition of voltage-sensitive sodium channels in neuroblastoma cells and synaptosomes by the anticonvulsant drugs diphenylhydantoin and carbamazepine. ( Catterall, WA; Kuenzel, EA; Willow, M, 1984) |
| "We evaluated the causality of the association between intrauterine exposure to phenytoin and postnatal neuroblastoma using an in vitro lymphocyte toxicity assay for phenytoin-induced reactions in an unusual sibship." | 4.77 | Neuroblastoma after prenatal exposure to phenytoin: cause and effect? ( Demitrakoudis, D; Koren, G; Rieder, M; Shandling, B; Shear, NH; Sonely, M; Spielberg, SP; Weksberg, R, 1989) |
| " Differentiated human neuroblastoma SH-SY5Y cells were exposed to acrylamide, lindane, parathion, paraoxon, phenytoin, diazepam or caffeine for 72 hours." | 3.74 | Integration of in vitro neurotoxicity data with biokinetic modelling for the estimation of in vivo neurotoxicity. ( Blaauboer, B; Forsby, A, 2007) |
| "The action of the anticonvulsant drug phenytoin on K+ channels was investigated in neuroblastoma cells (N2A) by using the single-channel patch-clamp technique." | 3.70 | A discriminant block among K+ channel types by phenytoin in neuroblastoma cells. ( Lagostena, L; Nobile, M, 1998) |
| "The influence of diazepam, an agonist, and flumazenil (Ro 15-1788), an antagonist of the benzodiazepine receptor, on repetitive firing of action potentials in cultured spinal neurons and on voltage-dependent Na+ currents in cultured N2A neuroblastoma cells was examined." | 3.68 | Action of diazepam on the voltage-dependent Na+ current. Comparison with the effects of phenytoin, carbamazepine, lidocaine and flumazenil. ( Backus, KH; Pflimlin, P; Trube, G, 1991) |
| "The action of phenytoin on the inward calcium current (ICa) was studied in cells of the clonal mouse neuroblastoma X rat glioma hybrid line 108CC5 by the suction pipette technique for internal perfusion and voltage clamp." | 3.67 | Calcium channel block by phenytoin in neuroblastoma x glioma hybrid cells. ( Bodewei, R; Hering, S; Schubert, B; Winkler, J; Wollenberger, A, 1985) |
| "The actions of diphenylhydantoin (DPH) and carbamazepine (CBZ) on sodium channels in mouse neuroblastoma cells (clone N18) were analyzed using the patch voltage clamp procedure in the whole cell configuration." | 3.67 | Voltage clamp analysis of the inhibitory actions of diphenylhydantoin and carbamazepine on voltage-sensitive sodium channels in neuroblastoma cells. ( Catterall, WA; Gonoi, T; Willow, M, 1985) |
| "An increase in susceptibility of neuroblastoma cells to calcium was inhibited when the cells were treated with hypothermia, diphenylhydantoin, chlorpromazine or pentobarbital; all of these treatments affect membrane permeability to calcium or membrane-associated cell metabolism." | 3.67 | Prevention of an increase in susceptibility to calcium in a neuroblastoma cell line. ( Abe, K; Kogure, K, 1987) |
| "Phenytoin (diphenylhydantoin) inhibits the calcium-dependent increases in guanosine 3':5'-monophosphate (cGMP) produced by high potassium depolarization and by muscarinic receptor activation in N1E-115 neuroblastoma cells." | 3.66 | Phenytoin inhibition of cyclic guanosine 3':5'-monophosphate (cGMP) accumulation in neuroblastoma cells by calcium channel blockade. ( Study, RE, 1980) |
| " The dose-response relationships for carbamazepine and diphenylhydantoin inhibition of 22Na+ flux in N18 cells are shifted 1." | 1.27 | Inhibition of voltage-sensitive sodium channels in neuroblastoma cells and synaptosomes by the anticonvulsant drugs diphenylhydantoin and carbamazepine. ( Catterall, WA; Kuenzel, EA; Willow, M, 1984) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 15 (65.22) | 18.7374 |
| 1990's | 5 (21.74) | 18.2507 |
| 2000's | 2 (8.70) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (4.35) | 2.80 |
| Authors | Studies |
|---|---|
| Kakumoto, M | 1 |
| Shimokawa, K | 1 |
| Ueshima, S | 1 |
| Hira, D | 1 |
| Okano, T | 1 |
| Forsby, A | 1 |
| Blaauboer, B | 1 |
| Study, RE | 1 |
| Matsuki, N | 1 |
| Quandt, FN | 2 |
| Ten Eick, RE | 1 |
| Yeh, JZ | 1 |
| Willow, M | 2 |
| Kuenzel, EA | 1 |
| Catterall, WA | 2 |
| Allen, RW | 2 |
| Jung, AL | 2 |
| Ogden, B | 1 |
| Bentley, FL | 1 |
| Lang, DG | 1 |
| Wang, CM | 1 |
| Cooper, BR | 1 |
| Nobile, M | 2 |
| Vercellino, P | 1 |
| Lagostena, L | 1 |
| LeTiran, A | 1 |
| Stables, JP | 1 |
| Kohn, H | 1 |
| Sherman, S | 1 |
| Roizen, N | 1 |
| Tuttle, JB | 1 |
| Richelson, E | 1 |
| Lewin, E | 1 |
| al-Shammri, S | 1 |
| Guberman, A | 1 |
| Hsu, E | 1 |
| Backus, KH | 1 |
| Pflimlin, P | 1 |
| Trube, G | 1 |
| Bodewei, R | 1 |
| Hering, S | 1 |
| Schubert, B | 1 |
| Winkler, J | 1 |
| Wollenberger, A | 1 |
| Twombly, DA | 1 |
| Yoshii, M | 1 |
| Narahashi, T | 1 |
| Gonoi, T | 1 |
| Koren, G | 1 |
| Demitrakoudis, D | 1 |
| Weksberg, R | 1 |
| Rieder, M | 1 |
| Shear, NH | 1 |
| Sonely, M | 1 |
| Shandling, B | 1 |
| Spielberg, SP | 1 |
| Abe, K | 1 |
| Kogure, K | 1 |
| Royer, P | 1 |
1 review available for phenytoin and Neuroblastoma
| Article | Year |
|---|---|
Neuroblastoma after prenatal exposure to phenytoin: cause and effect?
Topics: Bone and Bones; Female; Humans; Lymphocytes; Male; Neuroblastoma; Phenytoin; Pregnancy; Prenatal Exp | 1989 |
22 other studies available for phenytoin and Neuroblastoma
| Article | Year |
|---|---|
Effects of antiepileptic drugs' administration during pregnancy on the nerve cell proliferation and axonal outgrowth of human neuroblastoma SH-SY5Y nerve cells.
Topics: Anticonvulsants; Carbamazepine; Cell Line, Tumor; Cell Proliferation; Child; Epilepsy; Female; Human | 2021 |
Integration of in vitro neurotoxicity data with biokinetic modelling for the estimation of in vivo neurotoxicity.
Topics: Acrylamide; Animals; Anticonvulsants; Brain Neoplasms; Caffeine; Calcium Channels; Central Nervous S | 2007 |
Phenytoin inhibition of cyclic guanosine 3':5'-monophosphate (cGMP) accumulation in neuroblastoma cells by calcium channel blockade.
Topics: Acetylcholine; Anticonvulsants; Binding, Competitive; Calcium; Calcium Channel Blockers; Cells, Cult | 1980 |
Characterization of the block of sodium channels by phenytoin in mouse neuroblastoma cells.
Topics: Action Potentials; Animals; Cell Line; In Vitro Techniques; Ion Channels; Membrane Potentials; Mice; | 1984 |
Inhibition of voltage-sensitive sodium channels in neuroblastoma cells and synaptosomes by the anticonvulsant drugs diphenylhydantoin and carbamazepine.
Topics: Animals; Batrachotoxins; Brain; Carbamazepine; Electric Conductivity; Ion Channels; Membrane Potenti | 1984 |
Fetal hydantoin syndrome and malignancy.
Topics: Brain Neoplasms; Female; Fetal Alcohol Spectrum Disorders; Humans; Hydantoins; Infant, Newborn; Neur | 1984 |
Fetal hydantoin syndrome, neuroblastoma, and hemorrhagic disease in a neonate.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Epilepsy; Female; Humans; Hydantoins; Infant, | 1980 |
Lamotrigine, phenytoin and carbamazepine interactions on the sodium current present in N4TG1 mouse neuroblastoma cells.
Topics: Animals; Anticonvulsants; Carbamazepine; Dose-Response Relationship, Drug; Lamotrigine; Mice; Neurob | 1993 |
Inhibition of delayed rectifier K+ channels by phenytoin in rat neuroblastoma cells.
Topics: Animals; Anticonvulsants; Neuroblastoma; Patch-Clamp Techniques; Phenytoin; Potassium Channels; Rats | 1997 |
A discriminant block among K+ channel types by phenytoin in neuroblastoma cells.
Topics: Animals; Anticonvulsants; Brain Neoplasms; Membrane Potentials; Neuroblastoma; Patch-Clamp Technique | 1998 |
Functionalized amino acid anticonvulsants: synthesis and pharmacological evaluation of conformationally restricted analogues.
Topics: Amino Acids; Animals; Anticonvulsants; Catalysis; Crystallography, X-Ray; Cyclization; Drug Design; | 2001 |
Fetal hydantoin syndrome and neuroblastoma.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adrenal Gland Neoplasms; Child, Preschool; Fem | 1976 |
Phenytoin action on the excitable membrane of mouse neuroblastoma.
Topics: Action Potentials; Animals; Calcium; Cells, Cultured; Membrane Potentials; Membranes; Mice; Neoplasm | 1979 |
Effects of phenytoin on the release of 14C-adenine derivatives.
Topics: Adenine; Animals; Astrocytoma; Brain Neoplasms; Carbamazepine; Cells, Cultured; Cerebral Cortex; Hyp | 1977 |
Neuroblastoma and fetal exposure to phenytoin in a child without dysmorphic features.
Topics: Abnormalities, Drug-Induced; Child, Preschool; Humans; Male; Nervous System Neoplasms; Neuroblastoma | 1992 |
Action of diazepam on the voltage-dependent Na+ current. Comparison with the effects of phenytoin, carbamazepine, lidocaine and flumazenil.
Topics: Action Potentials; Animals; Carbamazepine; Cell Line; Cells, Cultured; Diazepam; Embryo, Mammalian; | 1991 |
Calcium channel block by phenytoin in neuroblastoma x glioma hybrid cells.
Topics: Action Potentials; Animals; Anticonvulsants; Calcium; Calcium Channel Blockers; Glioma; Hybrid Cells | 1985 |
Mechanisms of calcium channel block by phenytoin.
Topics: Animals; Calcium; Cell Line; Dose-Response Relationship, Drug; Electric Conductivity; Ion Channels; | 1988 |
Voltage clamp analysis of the inhibitory actions of diphenylhydantoin and carbamazepine on voltage-sensitive sodium channels in neuroblastoma cells.
Topics: Animals; Carbamazepine; Cells, Cultured; Electric Stimulation; Ion Channels; Mice; Neuroblastoma; Ph | 1985 |
Modification of slow inactivation of single sodium channels by phenytoin in neuroblastoma cells.
Topics: Animals; Dose-Response Relationship, Drug; Electric Conductivity; Electrophysiology; In Vitro Techni | 1988 |
Prevention of an increase in susceptibility to calcium in a neuroblastoma cell line.
Topics: Calcium; Cell Membrane Permeability; Cell Survival; Chlorpromazine; Cold Temperature; Flunarizine; H | 1987 |
[Postnatal effects of intrauterine chemical stress].
Topics: Adolescent; Adrenal Gland Neoplasms; Adult; Dyskinesia, Drug-Induced; Failure to Thrive; Female; Fet | 1985 |