phenytoin has been researched along with Neuralgia in 26 studies
Neuralgia: Intense or aching pain that occurs along the course or distribution of a peripheral or cranial nerve.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To assess the analgesic efficacy and adverse effects of the antiepileptic drug phenytoin in neuropathic pain and fibromyalgia." | 8.88 | Phenytoin for neuropathic pain and fibromyalgia in adults. ( Birse, F; Derry, S; Moore, RA, 2012) |
| "Baclofen has significantly exhibited analgesic efficacy: all groups, as a whole, were improved by 68." | 6.65 | Efficacy of baclofen in trigeminal neuralgia and some other painful conditions. A clinical trial. ( Leo, A; Marano, E; Steardo, L, 1984) |
| "To determine whether biological maturation influences the kinetics of carbamazepine-serum protein binding, the carbamazepine free fraction (%) was investigated in the serum of 66 patients, ranging from 4 to 83 years, with epilepsy or trigeminal neuralgia, treated with carbamazepine alone or carbamazepine in combination with phenytoin, phenobarbital, and/or valproic acid, over a relatively long period." | 5.09 | Age-related alteration of carbamazepine-serum protein binding in man. ( Koyama, H; Mori, S; Nakajima, K; Sugioka, N; Uno, A, 1999) |
| "To assess the analgesic efficacy and adverse effects of the antiepileptic drug phenytoin in neuropathic pain and fibromyalgia." | 4.88 | Phenytoin for neuropathic pain and fibromyalgia in adults. ( Birse, F; Derry, S; Moore, RA, 2012) |
| "Since anticonvulsants have been used for treating neuralgias, an interest has arisen to experimentally test vigabatrin for its gabaergic mechanism of action." | 3.70 | Possible analgesic effect of vigabatrin in animal experimental chronic neuropathic pain. ( Alves, ND; de Carvalho, AM; de Castro-Costa, CM; Santos, FJ; Silveira, DG, 1999) |
| "Oral neuropathic pain medication often has insufficient pain relief and side effects." | 3.11 | Enriched enrollment randomized double-blind placebo-controlled cross-over trial with phenytoin cream in painful chronic idiopathic axonal polyneuropathy (EPHENE): a study protocol. ( Keppel Hesselink, JM; Kopsky, DJ; Notermans, NC; van Eijk, RPA; Vrancken, AFJE; Warendorf, JK, 2022) |
| "Phenytoin was the first oral anticonvulsant used as an analgesic for neuropathic pain." | 2.69 | Intravenous infusion of phenytoin relieves neuropathic pain: a randomized, double-blinded, placebo-controlled, crossover study. ( McCleane, GJ, 1999) |
| "Baclofen has significantly exhibited analgesic efficacy: all groups, as a whole, were improved by 68." | 2.65 | Efficacy of baclofen in trigeminal neuralgia and some other painful conditions. A clinical trial. ( Leo, A; Marano, E; Steardo, L, 1984) |
| "Neuropathic pain is one of the key features of (classical) Fabry disease (FD)." | 2.53 | Pain management strategies for neuropathic pain in Fabry disease--a systematic review. ( Biegstraaten, M; Hollak, CE; Linthorst, GE; Schuller, Y; Van Schaik, IN, 2016) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 11 (42.31) | 18.7374 |
| 1990's | 5 (19.23) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 8 (30.77) | 24.3611 |
| 2020's | 2 (7.69) | 2.80 |
| Authors | Studies |
|---|---|
| King, AM | 3 |
| Salomé, C | 3 |
| Dinsmore, J | 2 |
| Salomé-Grosjean, E | 2 |
| De Ryck, M | 3 |
| Kaminski, R | 3 |
| Valade, A | 2 |
| Kohn, H | 3 |
| Stables, JP | 1 |
| Baruah, PK | 1 |
| Provins, L | 1 |
| Walls, TH | 1 |
| Grindrod, SC | 1 |
| Beraud, D | 1 |
| Zhang, L | 1 |
| Baheti, AR | 1 |
| Dakshanamurthy, S | 1 |
| Patel, MK | 1 |
| Brown, ML | 1 |
| MacArthur, LH | 1 |
| Kopsky, DJ | 2 |
| van Eijk, RPA | 1 |
| Warendorf, JK | 1 |
| Keppel Hesselink, JM | 2 |
| Notermans, NC | 1 |
| Vrancken, AFJE | 1 |
| Russell, AL | 1 |
| Hesselink, JMK | 1 |
| Abdulmajeed, WI | 1 |
| Ibrahim, RB | 1 |
| Ishola, AO | 1 |
| Balogun, WG | 1 |
| Cobham, AE | 1 |
| Amin, A | 1 |
| Schuller, Y | 1 |
| Linthorst, GE | 1 |
| Hollak, CE | 1 |
| Van Schaik, IN | 1 |
| Biegstraaten, M | 1 |
| Birse, F | 1 |
| Derry, S | 1 |
| Moore, RA | 1 |
| KONG, Y | 1 |
| HEYMAN, A | 1 |
| ENTMAN, ML | 1 |
| MCINTOSH, HD | 1 |
| Steardo, L | 1 |
| Leo, A | 1 |
| Marano, E | 1 |
| Rushton, JG | 1 |
| Stevens, JC | 1 |
| Miller, RH | 1 |
| Occhiogrosso, M | 1 |
| De Tommasi, A | 1 |
| Vailati, G | 1 |
| McCleane, GJ | 1 |
| Koyama, H | 1 |
| Sugioka, N | 1 |
| Uno, A | 1 |
| Mori, S | 1 |
| Nakajima, K | 1 |
| Alves, ND | 1 |
| de Castro-Costa, CM | 1 |
| de Carvalho, AM | 1 |
| Santos, FJ | 1 |
| Silveira, DG | 1 |
| Covington, EC | 1 |
| Taylor, PH | 1 |
| Gray, K | 1 |
| Bicknell, PG | 1 |
| Rees, JR | 1 |
| Eadie, MJ | 1 |
| Loeser, JD | 1 |
| Raskin, NH | 1 |
| Levinson, S | 1 |
| Hoffman, PM | 1 |
| Pickett, JB | 1 |
| Fields, HL | 1 |
| Khero, BA | 1 |
| Mullins, CB | 1 |
| Hallaq, IY | 1 |
| Harris, JD | 1 |
| Toman, JE | 1 |
| Sabelli, HC | 1 |
| Meyer, JS | 1 |
| Binns, PM | 1 |
| Ericsson, AD | 1 |
| Vulpe, M | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Enrichment Randomized Double-blind, Placebo-controlled Cross-over Trial With PHEnytoin Cream in Patients With Painful Chronic Idiopathic Axonal polyNEuropathy[NCT04647877] | Phase 2/Phase 3 | 81 participants (Actual) | Interventional | 2020-09-17 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
5 reviews available for phenytoin and Neuralgia
| Article | Year |
|---|---|
Phenytoin repositioned in wound healing: clinical experience spanning 60 years.
Topics: Administration, Topical; Bipolar Disorder; Chemistry, Pharmaceutical; Drug Repositioning; Humans; Ne | 2018 |
Pain management strategies for neuropathic pain in Fabry disease--a systematic review.
Topics: Amines; Anticonvulsants; Carbamazepine; Cyclohexanecarboxylic Acids; Fabry Disease; Gabapentin; gamm | 2016 |
Phenytoin for neuropathic pain and fibromyalgia in adults.
Topics: Adult; Analgesics; Anticonvulsants; Fibromyalgia; Humans; Neuralgia; Pain Management; Phenytoin | 2012 |
Anticonvulsants for neuropathic pain and detoxification.
Topics: Acetates; Amines; Anticonvulsants; Carbamazepine; Clonazepam; Cyclohexanecarboxylic Acids; Gabapenti | 1998 |
Glossopharyngeal neuralgia with syncope.
Topics: Adult; Aged; Bradycardia; Carbamazepine; Female; Glossopharyngeal Nerve; Humans; Male; Middle Aged; | 1977 |
4 trials available for phenytoin and Neuralgia
| Article | Year |
|---|---|
Enriched enrollment randomized double-blind placebo-controlled cross-over trial with phenytoin cream in painful chronic idiopathic axonal polyneuropathy (EPHENE): a study protocol.
Topics: Cross-Over Studies; Double-Blind Method; Humans; Neuralgia; Phenytoin; Polyneuropathies; Quality of | 2022 |
Efficacy of baclofen in trigeminal neuralgia and some other painful conditions. A clinical trial.
Topics: Adult; Amputation Stumps; Baclofen; Carbamazepine; Clinical Trials as Topic; Female; Humans; Male; M | 1984 |
Intravenous infusion of phenytoin relieves neuropathic pain: a randomized, double-blinded, placebo-controlled, crossover study.
Topics: Adult; Analgesics; Cross-Over Studies; Double-Blind Method; Female; Follow-Up Studies; Half-Life; Hu | 1999 |
Age-related alteration of carbamazepine-serum protein binding in man.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Anticonvulsants; Child; Child, Preschool; Diethyl | 1999 |
17 other studies available for phenytoin and Neuralgia
| Article | Year |
|---|---|
Primary amino acid derivatives: compounds with anticonvulsant and neuropathic pain protection activities.
Topics: Amino Acids; Analgesics; Animals; Anticonvulsants; Convulsants; Electroshock; Formaldehyde; Male; Mi | 2011 |
Primary amino acid derivatives: substitution of the 4'-N'-benzylamide site in (R)-N'-benzyl 2-amino-3-methylbutanamide, (R)-N'-benzyl 2-amino-3,3-dimethylbutanamide, and (R)-N'-benzyl 2-amino-3-methoxypropionamide provides potent anticonvulsants with pain
Topics: Amino Acids; Analgesics; Animals; Anticonvulsants; Butyrates; Male; Mice; Neuralgia; Pain Measuremen | 2011 |
Synthesis, anticonvulsant activity, and neuropathic pain-attenuating activity of N-benzyl 2-amino-2-(hetero)aromatic acetamides.
Topics: Acetamides; Amino Acids; Animals; Anticonvulsants; Disease Models, Animal; Drug Evaluation, Preclini | 2012 |
Synthesis and biological evaluation of a fluorescent analog of phenytoin as a potential inhibitor of neuropathic pain and imaging agent.
Topics: Animals; Disease Models, Animal; Drug Design; Female; Fluorescence; Fluorescent Dyes; Models, Molecu | 2012 |
Phenytoin Cream for the Treatment of Sciatic Pain: Clinical Effects and Theoretical Considerations: Case Report.
Topics: Administration, Cutaneous; Analgesics; Animals; Chronic Pain; Humans; Male; Middle Aged; Nerve Compr | 2020 |
Amitriptyline and phenytoin prevents memory deficit in sciatic nerve ligation model of neuropathic pain.
Topics: Amitriptyline; Animals; Disease Models, Animal; Ligation; Male; Memory Disorders; Neuralgia; Pain Me | 2016 |
GLOSSOPHARYNGEAL NEURALGIA ASSOCIATED WITH BRADYCARDIA, SYNCOPE, AND SEIZURES.
Topics: Atropine; Bradycardia; Drug Therapy; Electrocardiography; Geriatrics; Glossopharyngeal Nerve; Glosso | 1964 |
Glossopharyngeal (vagoglossopharyngeal) neuralgia: a study of 217 cases.
Topics: Adolescent; Adult; Carbamazepine; Cocaine; Cranial Nerve Diseases; Geniculate Ganglion; Glossopharyn | 1981 |
Choroid plexus compression of glossopharyngeal nerve in patients with glossopharyngeal neuralgia.
Topics: Aged; Carbamazepine; Choroid Plexus; Female; Follow-Up Studies; Glossopharyngeal Nerve; Humans; Male | 1996 |
Possible analgesic effect of vigabatrin in animal experimental chronic neuropathic pain.
Topics: Analgesics; Animals; Anticonvulsants; Carbamazepine; Chronic Disease; Neuralgia; Phenytoin; Rats; Ra | 1999 |
The management of facial pain.
Topics: Bruxism; Carbamazepine; Diagnosis, Differential; Ergotamine; Face; Female; Herpes Zoster; Humans; Ma | 1975 |
Neuralgia.
Topics: Anesthesia, Conduction; Carbamazepine; Cranial Nerves; Ergotamine; Herpes Zoster; Humans; Methysergi | 1973 |
Postsympathectomy neuralgia. Amelioration with diphenylhydantoin and carbamazepine.
Topics: Adult; Aged; Carbamazepine; Drug Therapy, Combination; Female; Ganglia, Autonomic; Humans; Intermitt | 1974 |
Cardiac syncope due to glossopharyngeal neuralgia. Treatment with a transvenous pacemaker.
Topics: Adult; Bradycardia; Denervation; Female; Glossopharyngeal Nerve; Heart Arrest; Humans; Neuralgia; Pa | 1971 |
The syndrome of postherpetic neuralgia: complication and an approach to therapy.
Topics: Aged; Arm; Carbamazepine; Female; Herpes Zoster; Humans; Neuralgia; Paralysis; Phenytoin | 1969 |
Comparative neuronal mechanisms.
Topics: Action Potentials; Animals; Annelida; Anura; Axons; Cell Membrane; Electric Stimulation; Epilepsy; G | 1969 |
Sphenopalatine gangionectomy for cluster headache.
Topics: Adult; Analgesics; Caffeine; Carbamazepine; Cortisone; Diazepam; Ergotamine; Female; Ganglia, Autono | 1970 |