phenytoin has been researched along with Nervous System Diseases in 55 studies
Nervous System Diseases: Diseases of the central and peripheral nervous system. This includes disorders of the brain, spinal cord, cranial nerves, peripheral nerves, nerve roots, autonomic nervous system, neuromuscular junction, and muscle.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Twenty-nine complications were burning pain at the IV site, and 36 were related to excessive total dose of phenytoin and resultant drug intoxication." | 5.27 | Complications of intravenous phenytoin for acute treatment of seizures. Recommendations for usage. ( Drury, LR; Earnest, MP; Marx, JA, 1983) |
| " Reversible dystonia may occasionally be precipitated by phenytoin or carbamazepine; asterixis by phenytoin, barbiturates or carbamazepine; and, more commonly, tremor by valproate." | 4.77 | Adverse neuropsychiatric effects of anticonvulsant drugs. ( Reynolds, EH; Trimble, MR, 1985) |
| " The anticonvulsant activity of all of the synthesized compounds was evaluated against maximal electrical shock (MES) and subcutaneous pentylenetetrazole (scPTZ) induced seizures." | 3.76 | Synthesis and anticonvulsant activity of 4-oxo and 4-thioxo-8-bromobenzopyran derivatives. ( Abd El-Latif, HA; Abu Yossef, HA; Hassan, GS; Ragab, FA; Yahya, TA, 2010) |
| " A more severe grade of neonatal encephalopathy, a higher number of neonatal seizures, the neonatal use of phenytoin, diffuse abnormalities on imaging, and abnormal findings on neurologic examination at neonatal discharge were all significantly (P<0." | 3.75 | The spectrum of abnormal neurologic outcomes subsequent to term intrapartum asphyxia. ( Al-Macki, N; Hall, N; Miller, SP; Shevell, M, 2009) |
| "Phenytoin has a wide range of pharmacologic effects other than its anticonvulsant activity." | 3.75 | Phenytoin revisited. ( Finkel, MJ, 1984) |
| "Phenytoin toxicity may result from intentional overdose, dosage adjustments, drug interactions, or alterations in physiology." | 2.43 | Phenytoin poisoning. ( Craig, S, 2005) |
| "Neuropathic cranial pain, i." | 2.42 | Neuropathic cranial pain. ( Annovazzi, PO; Colombo, B; Comi, G, 2003) |
| "Gabapentin has demonstrated efficacy, specifically in painful diabetic neuropathy and postherpetic neuralgia." | 2.41 | Use of anticonvulsants for treatment of neuropathic pain. ( Backonja, MM, 2002) |
| " Adverse effects of antiepileptic treatment may affect the patient's quality of life to an even greater extent than the occurrence of seizures." | 2.39 | Adverse effects of established and new antiepileptic drugs: an attempted comparison. ( Gram, L; Rogvi-Hansen, B, 1995) |
| "There were 73 children with seizures, 80% of whom had a greater than 50% reduction in seizure frequency following the start of simple anticonvulsant medication." | 1.32 | A review of neurological disorders presenting at a paediatric neurology clinic and response to anticonvulsant therapy in Gambian children. ( Allen, S; Burton, KJ, 2003) |
| "Marked cerebellar dysfunction and persistent vomiting were observed, with an initial serum phenytoin concentration of 181 micromol/L." | 1.32 | Phenytoin overdose complicated by prolonged intoxication and residual neurological deficits. ( Craig, S, 2004) |
| "Seizures are a recognized manifestation of neurosarcoidosis, but their clinical relevance is not well established." | 1.28 | Clinical implications of seizures in neurosarcoidosis. ( Krumholz, A; Stern, BJ; Stern, EG, 1991) |
| " Iatrogenic causes of intoxication were common and included increased daily dosage and intravenous loading in the emergency room for single seizures in patients with subtherapeutic serum phenytoin levels." | 1.28 | Phenytoin intoxication. ( Devinsky, O; Motiwala, R; Murphy, JM, 1991) |
| "Phenytoin (DPH) was delivered to the brain by a dihydropyridine in equilibrium pyridinium salt redox system, which was evaluated for anticonvulsant activity." | 1.28 | Improved anticonvulsant activity of phenytoin by a redox brain delivery system. III: Brain uptake and pharmacological effects. ( Bodor, NS; Murakami, T; Nath, C; Pop, E; Shek, E, 1989) |
| "Phenytoin has been proposed in the management of patients with the syndrome of inappropriate secretion of anti-diuretic hormone (SIADH) of neurological origin who fail to respond to water restriction." | 1.28 | Lack of efficacy of phenytoin in the syndrome of inappropriate anti-diuretic hormone secretion of neurological origin. ( Decaux, G; Przedborski, S; Soupart, A, 1989) |
| "0 g of misonidazole, severe nausea and vomiting are prominent, so that this side effect is a determining factor in the treatment fractionation." | 1.27 | The role of microsomal enzyme inducers in the reduction of misonidazole neurotoxicity. ( Bleehen, NM; Jones, DH; Smith, NC; Workman, P, 1983) |
| "Twenty-nine complications were burning pain at the IV site, and 36 were related to excessive total dose of phenytoin and resultant drug intoxication." | 1.27 | Complications of intravenous phenytoin for acute treatment of seizures. Recommendations for usage. ( Drury, LR; Earnest, MP; Marx, JA, 1983) |
| "This syndrome consists of sustained seizures, resembling amygdaloid kindled seizures, and acute destruction of neural elements in limbic brain regions (amygdala, olfactory cortex, hippocampus, lateral septum and several thalamic nuclei)." | 1.26 | Only certain anticonvulsants protect against kainate neurotoxicity. ( Fuller, TA; Olney, JW, 1981) |
| "Phenytoin plasma levels were measured by gas chromatography for up to 48 hours after dosing." | 1.26 | Phenytoin toxicity and blood levels after a large oral dose. ( Evens, RP; Fraser, DG; Ludden, TM; Sutherland, EW, 1980) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 35 (63.64) | 18.7374 |
| 1990's | 10 (18.18) | 18.2507 |
| 2000's | 7 (12.73) | 29.6817 |
| 2010's | 2 (3.64) | 24.3611 |
| 2020's | 1 (1.82) | 2.80 |
| Authors | Studies |
|---|---|
| Uno, H | 1 |
| Kurokawa, M | 1 |
| Masuda, Y | 1 |
| Nishimura, H | 1 |
| Nguyen, JV | 1 |
| Yaw, T | 1 |
| Gratton, H | 1 |
| Al-Macki, N | 1 |
| Miller, SP | 1 |
| Hall, N | 1 |
| Shevell, M | 1 |
| Ragab, FA | 1 |
| Hassan, GS | 1 |
| Abu Yossef, HA | 1 |
| Yahya, TA | 1 |
| Abd El-Latif, HA | 1 |
| Abramov, JP | 1 |
| Tran, A | 1 |
| Shapiro, AM | 1 |
| Wells, PG | 1 |
| Backonja, MM | 1 |
| Burton, KJ | 1 |
| Allen, S | 1 |
| Colombo, B | 1 |
| Annovazzi, PO | 1 |
| Comi, G | 1 |
| Craig, S | 2 |
| Marsh, E | 1 |
| O'Callaghan, P | 1 |
| Smith, P | 1 |
| Rivey, MP | 1 |
| Schottelius, DD | 1 |
| Berg, MJ | 1 |
| Finkel, MJ | 1 |
| Nelson, DF | 1 |
| Gillespie, BW | 1 |
| Diener, MD | 1 |
| Davis, DR | 1 |
| Wasserman, T | 1 |
| Phillips, TL | 1 |
| Stetz, J | 1 |
| Jones, DH | 1 |
| Bleehen, NM | 1 |
| Workman, P | 1 |
| Smith, NC | 1 |
| Fuller, TA | 1 |
| Olney, JW | 1 |
| Earnest, MP | 1 |
| Marx, JA | 1 |
| Drury, LR | 1 |
| Sillanpää, M | 1 |
| Wessely, P | 1 |
| Mayr, N | 1 |
| Binder, H | 1 |
| Klingler, D | 1 |
| Evens, RP | 1 |
| Fraser, DG | 1 |
| Ludden, TM | 1 |
| Sutherland, EW | 1 |
| von Albert, HH | 1 |
| Privitera, M | 1 |
| Fincham, R | 1 |
| Penry, J | 1 |
| Reife, R | 1 |
| Kramer, L | 1 |
| Pledger, G | 1 |
| Karim, R | 1 |
| Rogvi-Hansen, B | 1 |
| Gram, L | 1 |
| Koch, S | 1 |
| Jäger-Roman, E | 1 |
| Lösche, G | 1 |
| Nau, H | 1 |
| Rating, D | 1 |
| Helge, H | 1 |
| Ebadi, M | 1 |
| Ziegler, DK | 1 |
| Sobue, I | 1 |
| Boldyrev, AI | 1 |
| Fleĭs, EP | 1 |
| Vaĭntrub, MIa | 1 |
| Fishman, MA | 1 |
| Charnaia, ES | 1 |
| Beer, ET | 1 |
| Schain, RJ | 1 |
| Raskin, NH | 1 |
| Fishman, RA | 1 |
| Zapadniuk, VI | 1 |
| Zaika, MU | 1 |
| Yagi, K | 1 |
| Watanabe, M | 1 |
| Jalil, P | 1 |
| Krumholz, A | 1 |
| Stern, BJ | 1 |
| Stern, EG | 1 |
| Murphy, JM | 1 |
| Motiwala, R | 1 |
| Devinsky, O | 1 |
| Ronin, DI | 1 |
| Wu, YC | 1 |
| Sahgal, V | 1 |
| MacLean, IC | 1 |
| Vorhees, CV | 1 |
| Rindler, JM | 1 |
| Minck, DR | 1 |
| Skelton, WP | 1 |
| Skelton, NK | 1 |
| Piccione, E | 1 |
| Ticconi, C | 1 |
| Cennamo, M | 1 |
| Shek, E | 1 |
| Murakami, T | 1 |
| Nath, C | 1 |
| Pop, E | 1 |
| Bodor, NS | 1 |
| Decaux, G | 1 |
| Przedborski, S | 1 |
| Soupart, A | 1 |
| Reynolds, EH | 1 |
| Trimble, MR | 1 |
| Melamed, E | 1 |
| Martinovits, G | 1 |
| Pikarsky, E | 1 |
| Rosenthal, J | 1 |
| Uzzan, A | 1 |
| Cantu, RC | 1 |
| Schwab, RS | 1 |
| Weckman, N | 1 |
| Lehtovaara, R | 1 |
| Gilland, O | 1 |
| Selby, G | 1 |
| Ang, MK | 1 |
| Guiang, R | 1 |
| Berger, AR | 1 |
| Lagos, JC | 1 |
| Kaeser, HE | 1 |
| Meeuwisse, G | 1 |
| Gamstorp, I | 1 |
| Tryding, N | 1 |
| Gordon, N | 1 |
| Osuntokun, BO | 1 |
16 reviews available for phenytoin and Nervous System Diseases
| Article | Year |
|---|---|
Use of anticonvulsants for treatment of neuropathic pain.
Topics: Acetates; Amines; Anticonvulsants; Cyclohexanecarboxylic Acids; Gabapentin; gamma-Aminobutyric Acid; | 2002 |
Neuropathic cranial pain.
Topics: Acetates; Amines; Analgesics; Analgesics, Non-Narcotic; Anticonvulsants; Antidepressive Agents, Tric | 2003 |
Phenytoin poisoning.
Topics: Anticonvulsants; Charcoal; Drug Interactions; Drug Overdose; Heart Diseases; Humans; Nervous System | 2005 |
The humble electrocardiogram.
Topics: Anticonvulsants; Arrhythmias, Cardiac; Brain Diseases; Electrocardiography; Heart; Humans; Nervous S | 2008 |
Phenytoin-folic acid: a review.
Topics: Folic Acid; Folic Acid Deficiency; Humans; Nervous System Diseases; Phenytoin; Tissue Distribution | 1984 |
Phenytoin revisited.
Topics: Angina Pectoris; Animals; Arrhythmias, Cardiac; Cerebrovascular Disorders; Clinical Trials as Topic; | 1984 |
Adverse effects of established and new antiepileptic drugs: an attempted comparison.
Topics: Animals; Anticonvulsants; Carbamazepine; Epilepsy; gamma-Aminobutyric Acid; Gastrointestinal Disease | 1995 |
The pharmacokinetic basis of therapeutics with special reference to drugs used in neurology.
Topics: Binding Sites; Biological Transport; Cell Membrane; Drug Interactions; Enzyme Induction; Humans; Hyd | 1975 |
Toxicity to the nervous system of diphenylhydantoin: a review.
Topics: Adrenal Cortex Hormones; Animals; Cardiovascular Diseases; Cerebellar Ataxia; Cerebellar Diseases; C | 1978 |
[Exogenous toxic neuropathy (author's transl)].
Topics: Acrylamides; Adolescent; Adult; Aged; Aldrin; Carbon Disulfide; Chloramphenicol; Clioquinol; DDT; Di | 1976 |
Febrile seizures: the treatment controversy.
Topics: Child; Epilepsy; Humans; Nervous System Diseases; Phenobarbital; Phenytoin; Recurrence; Seizures; Se | 1979 |
Neurologic disorders in renal failure (first of two parts).
Topics: Blood-Brain Barrier; Brain Diseases; Cerebrospinal Fluid Proteins; Diazepam; Epilepsy; Humans; Lidoc | 1976 |
[Neurotoxicity of antiepileptic drugs].
Topics: Adult; Anticonvulsants; Benzodiazepines; Carbamazepine; Child; Ethosuximide; Humans; Male; Nervous S | 1992 |
[Problems of neurological drug therapy in pregnancy].
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Antiparkinson Agents; Carbamazepine; Chelating Agents; | 1989 |
Adverse neuropsychiatric effects of anticonvulsant drugs.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Barbiturates; Benzodiazepines; Biogenic Amines; Carba | 1985 |
Current trends in Australian neurology.
Topics: Alcoholism; Amino Acids; Aminobutyrates; Animals; Australia; Catecholamines; Central Nervous System; | 1970 |
5 trials available for phenytoin and Nervous System Diseases
| Article | Year |
|---|---|
Phenytoin revisited.
Topics: Angina Pectoris; Animals; Arrhythmias, Cardiac; Cerebrovascular Disorders; Clinical Trials as Topic; | 1984 |
Is misonidazole neurotoxicity altered by the use of phenytoin and/or dexamethasone in RTOG 79-18 and RTOG 79-16?
Topics: Brain Neoplasms; Clinical Trials as Topic; Dexamethasone; Female; Glioma; Humans; Male; Middle Aged; | 1984 |
Topiramate placebo-controlled dose-ranging trial in refractory partial epilepsy using 600-, 800-, and 1,000-mg daily dosages. Topiramate YE Study Group.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Carboplatin; Dose-Response Relationship, Drug; Double-Blin | 1996 |
Antiepileptic drug treatment in pregnancy: drug side effects in the neonate and neurological outcome.
Topics: Anticonvulsants; Child; Drug Monitoring; Epilepsy; Female; Follow-Up Studies; Humans; Nervous System | 1996 |
Ceruloplasmin rise and PBI fall in serum due to diphenylhydantoin.
Topics: Adolescent; Adult; Aged; Ceruloplasmin; Clinical Trials as Topic; Female; Humans; Male; Middle Aged; | 1966 |
35 other studies available for phenytoin and Nervous System Diseases
| Article | Year |
|---|---|
Studies on 3-substituted 1,2-benzisoxazole derivatives. 6. Syntheses of 3-(sulfamoylmethyl)-1,2-benzisoxazole derivatives and their anticonvulsant activities.
Topics: Animals; Anticonvulsants; Benzoxazoles; Electroshock; Male; Mice; Nervous System Diseases; Postural | 1979 |
Incidence of neurobehavioral side effects associated with levetiracetam compared to phenytoin in traumatic brain injury patients.
Topics: Anticonvulsants; Brain Injuries, Traumatic; Humans; Incidence; Levetiracetam; Nervous System Disease | 2021 |
The spectrum of abnormal neurologic outcomes subsequent to term intrapartum asphyxia.
Topics: Anticonvulsants; Asphyxia Neonatorum; Cerebral Palsy; Female; Follow-Up Studies; Humans; Infant, New | 2009 |
Synthesis and anticonvulsant activity of 4-oxo and 4-thioxo-8-bromobenzopyran derivatives.
Topics: Animals; Anticonvulsants; Benzopyrans; Electroshock; Indicators and Reagents; Lethal Dose 50; Male; | 2010 |
Protective role of endogenous catalase in baseline and phenytoin-enhanced neurodevelopmental and behavioral deficits initiated in utero and in aged mice.
Topics: Aging; Animals; Behavior, Animal; Brain; Catalase; Female; Litter Size; Male; Maternal-Fetal Exchang | 2012 |
A review of neurological disorders presenting at a paediatric neurology clinic and response to anticonvulsant therapy in Gambian children.
Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Developmental Disabilities; Fem | 2003 |
Phenytoin overdose complicated by prolonged intoxication and residual neurological deficits.
Topics: Adult; Cerebellar Diseases; Charcoal; Critical Care; Drug Overdose; Emergency Medicine; Hemoperfusio | 2004 |
The role of microsomal enzyme inducers in the reduction of misonidazole neurotoxicity.
Topics: Adult; Aged; Drug Administration Schedule; Drug Interactions; Enzyme Induction; Half-Life; Humans; K | 1983 |
Only certain anticonvulsants protect against kainate neurotoxicity.
Topics: Animals; Anticonvulsants; Diazepam; Kainic Acid; Male; Nervous System Diseases; Phenobarbital; Pheny | 1981 |
Complications of intravenous phenytoin for acute treatment of seizures. Recommendations for usage.
Topics: Adolescent; Adult; Aged; Cardiovascular Diseases; Crystallization; Female; Humans; Infusions, Parent | 1983 |
Carbamazepine. Pharmacology and clinical uses.
Topics: Adult; Alcohol Withdrawal Delirium; Arrhythmias, Cardiac; Behavior; Carbamazepine; Child; Diabetes I | 1981 |
[Neurological signs in diphenylhydantoin intoxication (case reports and review) (author's transl)].
Topics: Adult; Biopsy; Cerebellar Ataxia; Electroencephalography; Epilepsy; Evoked Potentials; Female; Human | 1981 |
Phenytoin toxicity and blood levels after a large oral dose.
Topics: Adult; Blood Proteins; Cardiovascular Diseases; Gastrointestinal Diseases; Humans; Kinetics; Male; N | 1980 |
[Progress in clinical neurology 1970-1980. Experiences at the clinic for acute neurological diseases in Günzburg].
Topics: Cerebrovascular Disorders; Consciousness Disorders; Encephalitis; Germany, West; Hospitals, Special; | 1980 |
[Neurologic complications following medical treatment of epileptic patients].
Topics: Adolescent; Adult; Anticonvulsants; Ataxia; Benzodiazepines; Consciousness Disorders; Dysarthria; Ey | 1979 |
[Complications following treatment of arrhythmia with diphenin].
Topics: Adult; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Cerebrovascular Circulation; Humans; Male; Midd | 1979 |
Problems with the use of conventional anticonvulsant drugs in mentally retarded individuals.
Topics: Adolescent; Child; Child Behavior Disorders; Child, Preschool; Cognition; Epilepsy; Humans; Intellec | 1979 |
[Pharmacotherapeutic effectiveness of diphenin].
Topics: Aged; Arrhythmias, Cardiac; Brain; Heart; Humans; Labyrinth Diseases; Nervous System Diseases; Perip | 1975 |
Toxic reaction following the combined administration of fluoxetine and phenytoin: two case reports.
Topics: Aged; Aged, 80 and over; Depressive Disorder; Drug Therapy, Combination; Epilepsy; Female; Fluoxetin | 1992 |
Clinical implications of seizures in neurosarcoidosis.
Topics: Adolescent; Adult; Brain Diseases; Carbamazepine; Female; Humans; Male; Middle Aged; Nervous System | 1991 |
Phenytoin intoxication.
Topics: Adult; Electrocardiography; Female; Humans; Liver Function Tests; Male; Middle Aged; Nervous System | 1991 |
Intractable muscle pain syndrome, osteomalacia, and axonopathy in long-term use of phenytoin.
Topics: Aged; Humans; Male; Muscular Diseases; Nervous System Diseases; Osteomalacia; Pain; Phenytoin; Vitam | 1991 |
Effects of exposure period and nutrition on the developmental neurotoxicity of anticonvulsants in rats: short and long-term effects.
Topics: Animal Nutritional Physiological Phenomena; Animals; Anticonvulsants; Female; Male; Manganese; Nervo | 1990 |
Treatment of thiamine deficiency neuropathy with phenytoin.
Topics: Humans; Male; Middle Aged; Nervous System Diseases; Paresthesia; Phenytoin; Sensation; Thiamine Defi | 1990 |
Improved anticonvulsant activity of phenytoin by a redox brain delivery system. III: Brain uptake and pharmacological effects.
Topics: Animals; Anticonvulsants; Behavior, Animal; Brain; Chemical Phenomena; Chemistry, Physical; Chromato | 1989 |
Lack of efficacy of phenytoin in the syndrome of inappropriate anti-diuretic hormone secretion of neurological origin.
Topics: Adult; Aged; Female; Follow-Up Studies; Humans; Inappropriate ADH Syndrome; Male; Middle Aged; Nervo | 1989 |
Diphenylhydantoin and phenobarbital suppress the dopaminergic neurotoxicity of MPTP in mice.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Anticonvulsants; Male; Mice; Mice, Inbred C57 | 1986 |
Folic acid and anticonvulsants.
Topics: Anticonvulsants; Epilepsy; Folic Acid; Humans; Nervous System Diseases; Phenytoin | 1969 |
[American neurology for Swedish use].
Topics: Adrenocorticotropic Hormone; Ampicillin; Brain Diseases; Cerebrovascular Disorders; Contrast Media; | 1968 |
Diphenylhydantoin (Dilantin) neurotoxicity--a deceptive syndrome.
Topics: Aged; Ataxia; Capsules; Diagnosis, Differential; Epilepsy, Tonic-Clonic; Humans; Male; Medication Er | 1969 |
Diphenylhydantoin risks in children.
Topics: Child; Child, Preschool; Epilepsy; Humans; Medication Errors; Nervous System Diseases; Phenytoin; Su | 1972 |
[Neurotoxicity of drugs].
Topics: Arsenic; Drug-Related Side Effects and Adverse Reactions; Humans; Nervous System Diseases; Nitrofura | 1972 |
Effect of phenytoin on the tryptophan load test.
Topics: Adolescent; Age Factors; Child; Child, Preschool; Diagnosis, Differential; Epilepsy; Female; Humans; | 1968 |
Use of diphenylhydantoin in epilepsy treatment.
Topics: Ataxia; Chemical and Drug Induced Liver Injury; Epilepsy; Humans; Necrosis; Nervous System Diseases; | 1969 |
Anticonvulsant therapy, folic acid deficiency, and neuropsychiatric disorders.
Topics: Adolescent; Avitaminosis; Female; Folic Acid Deficiency; Humans; Nervous System Diseases; Phenytoin | 1969 |