phenytoin has been researched along with Nerve Degeneration in 15 studies
Nerve Degeneration: Loss of functional activity and trophic degeneration of nerve axons and their terminal arborizations following the destruction of their cells of origin or interruption of their continuity with these cells. The pathology is characteristic of neurodegenerative diseases. Often the process of nerve degeneration is studied in research on neuroanatomical localization and correlation of the neurophysiology of neural pathways.
| Excerpt | Relevance | Reference |
|---|---|---|
| " To determine whether phenytoin has a protective effect on axons in a neuroinflammatory model, we studied the effect of phenytoin on axonal degeneration in the optic nerve in MOG-induced experimental allergic encephalomyelitis (EAE)." | 7.71 | Neuroprotection of axons with phenytoin in experimental allergic encephalomyelitis. ( Black, JA; Lo, AC; Waxman, SG, 2002) |
| " To determine whether phenytoin has a protective effect on axons in a neuroinflammatory model, we studied the effect of phenytoin on axonal degeneration in the optic nerve in MOG-induced experimental allergic encephalomyelitis (EAE)." | 3.71 | Neuroprotection of axons with phenytoin in experimental allergic encephalomyelitis. ( Black, JA; Lo, AC; Waxman, SG, 2002) |
| "An infant with dysmorphic features was born to an epileptic mother who had taken phenytoin and sodium valproate throughout pregnancy." | 3.68 | Neocerebellar hypoplasia in a neonate following intra-uterine exposure to anticonvulsants. ( Hope, PL; Lindenbaum, RH; Squier, W, 1990) |
| "Cerebellar changes have been reported in relationship to epilepsy alone as well as to phenytoin therapy for the control of seizures." | 3.65 | Phenytoin-related cerebellar degeneration without seizures. ( Rapport, RL; Shaw, CM, 1977) |
| "We report a patient with limbic encephalitis associated with RP who presented with anti-glutamate receptor (GluR) epsilon2 (NR2B) autoantibodies in his cerebrospinal fluid and sera." | 1.35 | Autoantibodies to glutamate receptor GluRepsilon2 in a patient with limbic encephalitis associated with relapsing polychondritis. ( Kashihara, K; Kawada, S; Takahashi, Y, 2009) |
| "Phenytoin has been shown to cause choreiform movements, peripheral neuropathy, and cognitive decline in some patients, but the pathological basis for these changes has not been elucidated." | 1.29 | Neuronal loss from the subthalamic nuclei in a patient with progressive chorea. ( Hedreen, JC; Sinard, JH, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (40.00) | 18.7374 |
| 1990's | 4 (26.67) | 18.2507 |
| 2000's | 4 (26.67) | 29.6817 |
| 2010's | 1 (6.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ruzza, P | 1 |
| Vitale, RM | 1 |
| Hussain, R | 1 |
| Biondi, B | 1 |
| Amodeo, P | 1 |
| Sechi, G | 1 |
| Siligardi, G | 1 |
| Kashihara, K | 1 |
| Kawada, S | 1 |
| Takahashi, Y | 1 |
| Lo, AC | 2 |
| Black, JA | 2 |
| Waxman, SG | 2 |
| Angehagen, M | 1 |
| Ben-Menachem, E | 1 |
| Rönnbäck, L | 1 |
| Hansson, E | 1 |
| Craner, MJ | 1 |
| Damarjian, TG | 1 |
| Liu, S | 1 |
| Hains, BC | 1 |
| Newcombe, J | 1 |
| Cuzner, ML | 1 |
| Blank, NK | 1 |
| Nishimura, RN | 1 |
| Seil, FJ | 1 |
| Koller, WC | 1 |
| Glatt, SL | 1 |
| Fox, JH | 1 |
| Sinard, JH | 1 |
| Hedreen, JC | 1 |
| Luef, G | 1 |
| Chemelli, A | 1 |
| Birbamer, G | 1 |
| Aichner, F | 1 |
| Bauer, G | 1 |
| Taki, K | 1 |
| Iwahashi, K | 1 |
| Kugoh, T | 1 |
| Matsuo, Y | 1 |
| Ichikawa, Y | 1 |
| Hosokawa, K | 1 |
| Suwaki, H | 1 |
| Rapport, RL | 1 |
| Shaw, CM | 1 |
| Squier, W | 1 |
| Hope, PL | 1 |
| Lindenbaum, RH | 1 |
| Welch, LK | 1 |
| Appenzeller, O | 1 |
| Bicknell, JM | 1 |
| Selhorst, JB | 1 |
| Kaufman, B | 1 |
| Horwitz, SJ | 1 |
| French, JH | 1 |
| Sherard, ES | 1 |
| Lubell, H | 1 |
| Brotz, M | 1 |
| Moore, CL | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Clinical Cohort Study of Association Between Steady State Phenytoin Treatment and Better Clinical Parameters of Glaucoma[NCT00739154] | 200 participants (Anticipated) | Observational | 2008-11-30 | Not yet recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
15 other studies available for phenytoin and Nerve Degeneration
| Article | Year |
|---|---|
Interactions of GFAP with ceftriaxone and phenytoin: SRCD and molecular docking and dynamic simulation.
Topics: Alexander Disease; alpha-Synuclein; Animals; Astrocytes; Binding Sites; Ceftriaxone; Glial Fibrillar | 2016 |
Autoantibodies to glutamate receptor GluRepsilon2 in a patient with limbic encephalitis associated with relapsing polychondritis.
Topics: Amygdala; Anti-Inflammatory Agents; Anticonvulsants; Atrophy; Autoantibodies; Biomarkers; Brain; Car | 2009 |
Neuroprotection of axons with phenytoin in experimental allergic encephalomyelitis.
Topics: Animals; Axons; Cell Death; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Imm | 2002 |
Topiramate protects against glutamate- and kainate-induced neurotoxicity in primary neuronal-astroglial cultures.
Topics: Animals; Animals, Newborn; Anticonvulsants; Astrocytes; Calcium; Calcium Signaling; Cell Membrane; C | 2003 |
Sodium channels contribute to microglia/macrophage activation and function in EAE and MS.
Topics: Animals; Axons; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Female; Gliosis | 2005 |
Phenytoin neurotoxicity in developing mouse cerebellum in tissue culture.
Topics: Animals; Cerebellar Nuclei; Cerebellum; Culture Techniques; Dendrites; Dose-Response Relationship, D | 1982 |
Phenytoin-induced cerebellar degeneration.
Topics: Cerebellar Diseases; Humans; Nerve Degeneration; Phenytoin | 1980 |
Neuronal loss from the subthalamic nuclei in a patient with progressive chorea.
Topics: Aged; Aged, 80 and over; Astrocytes; Brain; Cell Count; Cerebellar Diseases; Chorea; Epilepsy, Post- | 1995 |
Phenytoin overdosage and cerebellar atrophy in epileptic patients: clinical and MRI findings.
Topics: Adult; Atrophy; Cerebellar Diseases; Cerebellum; Drug Overdose; Epilepsy; Female; Humans; Magnetic R | 1994 |
Side effects of phenytoin related to the xenobiotics metabolism by cytochrome P-450-linked monooxygenase of liver microsomes in dark Agouti rats.
Topics: Animals; Cytochrome P-450 Enzyme System; Female; Inactivation, Metabolic; Male; Microsomes, Liver; N | 1993 |
Phenytoin-related cerebellar degeneration without seizures.
Topics: Cerebellum; Epilepsy; Female; Gliosis; Humans; Isoniazid; Middle Aged; Nerve Degeneration; Neuroglia | 1977 |
Neocerebellar hypoplasia in a neonate following intra-uterine exposure to anticonvulsants.
Topics: Abnormalities, Drug-Induced; Cerebellum; Drug Therapy, Combination; Epilepsy; Female; Humans; Nerve | 1990 |
Peripheral neuropathy with myokymia, sustained muscular contraction, and continuous motor unit activity.
Topics: Action Potentials; Adult; Calcium; Decamethonium Compounds; Demyelinating Diseases; Edrophonium; Ele | 1972 |
Diphenylhydantoin-induced cerebellar degeneration.
Topics: Adolescent; Cerebellar Ataxia; Cerebellar Diseases; Child; Electroencephalography; Epilepsy; Female; | 1972 |
Trichopoliodystrophy. I. Report of a case and biochemical studies.
Topics: Amino Acids; Brain Chemistry; Brain Diseases; Cerebellum; Cerebral Cortex; Cerebrosides; Cholesterol | 1972 |