phenytoin has been researched along with Nephrotic Syndrome in 10 studies
Nephrotic Syndrome: A condition characterized by severe PROTEINURIA, greater than 3.5 g/day in an average adult. The substantial loss of protein in the urine results in complications such as HYPOPROTEINEMIA; generalized EDEMA; HYPERTENSION; and HYPERLIPIDEMIAS. Diseases associated with nephrotic syndrome generally cause chronic kidney dysfunction.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The effect of chronic renal disease on the serum free fraction of phenytoin, diazepam and propranolol was examined in vitro among 60 conservatively treated patients with renal insufficiency of varying degree and different etiology, and in 10 patients with a nephrotic syndrome." | 3.67 | Serum protein binding of phenytoin, diazepam and propranolol in chronic renal diseases. ( Neuvonen, PJ; Tallgren, LG; Tiula, E, 1987) |
| " A 35-year-old man who had been taking a low dose of phenytoin for epilepsy presented with nephrotic syndrome and a mesangiocapillary glomerulonephritis." | 3.66 | Plasma exchange in the successful treatment of drug-induced renal disease. ( Short, AI; Swainson, CP; Thomson, D; Winney, RJ, 1982) |
| " As a consequence, shorter dosing intervals of these drugs seems to be advisable, rather than a reduction in the total daily dose." | 2.35 | Drug protein binding and the nephrotic syndrome. ( Azarnoff, DL; Gugler, R, 1976) |
| " No significant differences were seen in the pharmacokinetic parameters observed for antipyrine, a drug which is less than 10% bound to plasms proteins." | 1.25 | Pharmacokinetics of drugs in patients with the nephrotic syndrome. ( Azarnoff, DL; Cohlmia, JB; Gugler, R; Huffman, DH; Shoeman, DW, 1975) |
| " However, in these patients it was not necessary to diminish the dosage since the absolute concentration of unbond drug was unchanged due to a compensatory increase in the apparent volume of distribution and plasma clearance." | 1.25 | Diphenylhydantoin: correlation between protein binding and albumin concentration. ( Azarnoff, DL; Gugler, R; Shoeman, DW, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (90.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (10.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Akın, F | 1 |
| Kılıçaslan, C | 1 |
| Solak, ES | 1 |
| Uzun, M | 1 |
| Aygün, S | 1 |
| Arslan, Ş | 1 |
| Swainson, CP | 1 |
| Thomson, D | 1 |
| Short, AI | 1 |
| Winney, RJ | 1 |
| Gugler, R | 3 |
| Azarnoff, DL | 3 |
| Gibaldi, M | 1 |
| Shoeman, DW | 2 |
| Huffman, DH | 1 |
| Cohlmia, JB | 1 |
| Orlandini, G | 1 |
| Garini, G | 1 |
| Tiula, E | 1 |
| Tallgren, LG | 1 |
| Neuvonen, PJ | 1 |
| Horiguchi, T | 1 |
| Lippe, BM | 1 |
| Crandall, BF | 1 |
1 review available for phenytoin and Nephrotic Syndrome
| Article | Year |
|---|---|
Drug protein binding and the nephrotic syndrome.
Topics: Antipyrine; Blood Proteins; Clofibrate; Diazepam; Half-Life; Humans; Kinetics; Nephrotic Syndrome; P | 1976 |
9 other studies available for phenytoin and Nephrotic Syndrome
| Article | Year |
|---|---|
Posterior reversible encephalopathy syndrome in children: report of three cases.
Topics: Adolescent; Anticonvulsants; Antihypertensive Agents; Brain Stem; Cerebral Cortex; Child; Child, Pre | 2014 |
Plasma exchange in the successful treatment of drug-induced renal disease.
Topics: Adult; Anti-Glomerular Basement Membrane Disease; Antigen-Antibody Complex; Female; Glomerulonephrit | 1982 |
Drug distribution in renal failure.
Topics: Antipyrine; Clofibrate; Dose-Response Relationship, Drug; Drug Tolerance; Humans; Kidney Failure, Ch | 1977 |
Pharmacokinetics of drugs in patients with the nephrotic syndrome.
Topics: Adult; Antipyrine; Blood Proteins; Body Weight; Clofibrate; Dose-Response Relationship, Drug; Female | 1975 |
Diphenylhydantoin: correlation between protein binding and albumin concentration.
Topics: Half-Life; Humans; Nephrotic Syndrome; Phenytoin; Protein Binding; Serum Albumin | 1975 |
Phenytoin-induced nephrotic syndrome.
Topics: Aged; Aged, 80 and over; Epilepsy, Tonic-Clonic; Female; Humans; Nephrotic Syndrome; Phenytoin | 1989 |
Serum protein binding of phenytoin, diazepam and propranolol in chronic renal diseases.
Topics: Creatinine; Diazepam; Humans; Kidney Failure, Chronic; Nephrotic Syndrome; Orosomucoid; Phenytoin; P | 1987 |
[Clinical study on determination of blood thyroid hormone levels using the protein binding test--free thyroxine index in young children].
Topics: Age Factors; Androgens; Antithyroid Agents; Child; Child, Preschool; Down Syndrome; Dwarfism, Pituit | 1971 |
Turner syndrome with partial deletion of the X chromosome long arm.
Topics: Adolescent; Amenorrhea; Dermatoglyphics; Epilepsy, Absence; Epilepsy, Tonic-Clonic; Female; Follicle | 1973 |