phenytoin and Myoclonic Jerk studies

Research Excerpts

Excerpt	Relevance	Reference
" Following treatment with antiepileptic drugs (AEDs), the patient developed several rare complications: after beginning therapy with phenytoin, the patient developed pseudolymphoma; after monotherapy with carbamazepine (CBZ), the patient thereafter developed myoclonic jerks of upper and lower limbs upon awakening; after one year of treatment with valproate (VPA) the patient developed clinical and immuno-haematological signs of SLE."	3.69	Clinical case report: multiple idiosyncratic adverse effects of antiepileptic drugs in trisomy 9p. ( Diomedi, M; Gigli, GL; Masala, C; Placidi, F; Pomponi, MG; Scalise, A; Silvestri, G, 1996)
"Senegalese baboons (Papio papio), with a natural syndrome of photosensitive epilepsy, consistently show generalized myoclonic jerks if stimulated stroboscopically at hourly intervals, two to eight hours after the intravenous administration of allylglycine, 200 mg/kg."	3.65	A primate model for testing anticonvulsant drugs. ( Horton, RW; Meldrum, BS; Toseland, PA, 1975)
"The diagnosis of myoclonus was more difficult than those of epilepsy, because the clarification of pathogenesis and definition of diagnosis was lacked."	2.38	[Diagnosis and therapy of epilepsy and myoclonus]. ( Okamoto, Y; Ota, K, 1993)
"Ten hours later, the patient developed myoclonus of his upper extremities and face."	1.35	Polymyoclonus seizure resulting from accidental injection of tranexamic acid in spinal anesthesia. ( Arami, A; Jafari, A; Mohseni, K; Nobahar, MR, 2009)
"A diagnosis of bilateral diaphragmatic myoclonus was made by fluoroscopy and electromyography of both hemidiaphragms."	1.29	Diaphragmatic myoclonus: diagnosis by fluoroscopy and electromyography with response to phenytoin. ( Clapp, L; Salcedo, V; Whitlock, WL; Young, CR, 1995)
"Phenytoin has been observed to exert variable effects on dopamine metabolites and also may induce changes in serotonergic activity."	1.29	Postural myoclonus induced by phenytoin. ( Cabezas, MC; Clavería, LE; Duarte, J; Marcos, J; Sempere, AP, 1996)
"Jerk-locked averaging triggered by the myoclonus of the right deltoid muscle showed no pre-myoclonus spike at the scalp electrodes."	1.28	[A case of stimulus-sensitive segmental spinal myoclonus]. ( Kakigi, R; Kuroda, Y; Oda, K; Sagisaka, H; Shibasaki, H, 1989)
"Spontaneous myoclonus in alcohol withdrawal is likely to represent diffuse cerebral hyperirritability during the withdrawal state."	1.27	Recurrent spontaneous myoclonus in alcohol withdrawal. ( Drake, ME, 1983)
"To label asterixis or seizures nonspecific results of CNS disorders or results of nonspecific CNS disorders may be simply to avoid confronting our ignorance of the specific pathophysiologic mechanisms involved."	1.27	Asterixis: one type of negative myoclonus. ( Shahani, BT; Young, RR, 1986)
"A 28-year-old male of progressive myoclonus epilepsy was reported, who had showed a gradual progression in myoclonus, mental retardation and cerebellar symptoms, and had been treated with a large dosage of diphenylhydantoin."	1.26	A neuropathological case-study of myoclonus epilepsy. ( Ikeda, K; Ikeda, S; Namba, M; Nishikubo, M; Yoshimura, T, 1976)

Timeframe	Studies, this research(%)	All Research%
pre-1990	42 (82.35)	18.7374
1990's	7 (13.73)	18.2507
2000's	2 (3.92)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Authors	Studies
Mohseni, K	1
Jafari, A	1
Nobahar, MR	1
Arami, A	1
JABBOUR, JT	1
KIORBOE, E	1
PALUDAN, J	1
TROLLE, E	1
OVERVAD, E	1
KISHI, Y	1
MANMARU, S	1
FUKUI, S	1
AOKI, Y	1
FRENCH, JH	1
GRUETER, BB	1
DRUCKMAN, R	1
O'BRIEN, D	1
Burneo, JG	1
Miller, S	1
Bebin, EM	1
Prasad, A	1
Drake, ME	1
Shea, JJ	1
Emmett, JR	1
Alexander, GJ	2
Chatterjie, N	2
Kopeloff, LM	2
Grafova, VN	1
Danilova, EI	1
Ishii, K	1
Hayashi, A	1
Tamaoka, A	1
Usuki, S	1
Mizusawa, H	1
Shoji, S	1
Young, CR	2
Clapp, L	1
Salcedo, V	1
Whitlock, WL	2
Okamoto, Y	1
Ota, K	1
Duarte, J	1
Sempere, AP	1
Cabezas, MC	1
Marcos, J	1
Clavería, LE	1
Gigli, GL	1
Scalise, A	1
Silvestri, G	1
Diomedi, M	1
Placidi, F	1
Pomponi, MG	1
Masala, C	1
Meldrum, BS	1
Horton, RW	1
Toseland, PA	1
Jenner, P	1
Chadwick, D	1
Reynolds, EH	1
Marsden, CD	1
Destee, A	1
Verrier, A	1
Gelez, P	1
Warot, P	1
Lublin, FD	1
Tsairis, P	1
Streletz, LJ	1
Chambers, RA	1
Riker, WF	1
Van Poznak, A	2
Duckett, SW	1
Koskiniemi, M	1
Ikeda, K	1
Ikeda, S	1
Yoshimura, T	1
Namba, M	1
Nishikubo, M	1
Raskin, NH	1
Fishman, RA	1
Shapira, Y	1
Cederbaum, SD	1
Cancilla, PA	1
Nielsen, D	1
Lippe, BM	1
Kobayashi, I	1
Suzuki, H	1
Kondo, T	1
Yamauchi, T	1
Ohta, Y	1
Yamabayashi, H	1
Sagisaka, H	1
Kakigi, R	1
Shibasaki, H	1
Oda, K	1
Kuroda, Y	1
Fahn, S	1
Young, RR	1
Shahani, BT	1
Alexander, RB	1
Trauner, DA	1
Laitinen, L	1
Toivakka, E	1
Sibley, WA	1
Hauser, HM	1
Brewer, EJ	1
Huang, CY	2
McLeod, JG	2
Sampson, D	2
Hensley, WJ	2
Wallis, WE	1
Plum, F	1
Millichap, JG	2
Nixon, DW	1
Mayger, WE	1
Phillips, JR	1
Eldridge, FL	1
Rhee, RS	1
Margolin, M	1
Pellock, J	1
Tenser, RB	1
Corbett, JJ	1
Carter, S	1
Gold, A	1
Ortiz, WR	1
van Leeuwen, WS	1
Jennekens, F	1
Sterk, CE	1
Louis, S	1
Kutt, H	1
McDowell, F	1
Andermann, F	1
Eadie, MJ	1
Sohn, YJ	1
Levitt, B	1
Raines, A	1
Gottwald, W	1

Trial			Phase	Enrollment	Study Type	Start Date	Status
Seizures After Cardiac Surgery -- A Prospective Study With Continuous EEG Monitoring[NCT01291992]				100 participants (Actual)	Observational	2010-09-30	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Article	Year
[Diagnosis and therapy of epilepsy and myoclonus]. Nihon rinsho. Japanese journal of clinical medicine, 1993, Volume: 51, Issue:11 Topics: Acetates; Amines; Cerebral Cortex; Cyclohexanecarboxylic Acids; Electrophysiology; Epilepsy; Gabapen	1993
Neurologic disorders in renal failure (first of two parts). The New England journal of medicine, 1976, Jan-15, Volume: 294, Issue:3 Topics: Blood-Brain Barrier; Brain Diseases; Cerebrospinal Fluid Proteins; Diazepam; Epilepsy; Humans; Lidoc	1976
Posthypoxic action myoclonus: literature review update. Advances in neurology, 1986, Volume: 43 Topics: Adult; Clonazepam; Coma; Electroencephalography; Female; Functional Laterality; Heart Arrest; Humans	1986
Diagnosis and treatment of epilepsy: overview and general principles. Pediatrics, 1974, Volume: 53, Issue:4 Topics: Adolescent; Adult; Age Factors; Anticonvulsants; Child; Child, Preschool; Drug Therapy, Combination;	1974
Current drug therapy--antiepilepsy agents. American journal of hospital pharmacy, 1974, Volume: 31, Issue:12 Topics: Anticonvulsants; Barbiturates; Chemical Phenomena; Chemistry; Drug Interactions; Epilepsies, Partial	1974
Convulsions in children. The New England journal of medicine, 1968, Feb-08, Volume: 278, Issue:6 Topics: Child; Child, Preschool; Diazepam; Electroencephalography; Epilepsy; Ethosuximide; Humans; Infant; M	1968

Article	Year
Polymyoclonus seizure resulting from accidental injection of tranexamic acid in spinal anesthesia. Anesthesia and analgesia, 2009, Volume: 108, Issue:6 Topics: Anesthesia, General; Anesthesia, Spinal; Anticonvulsants; Antifibrinolytic Agents; Critical Care; Hu	2009
THE INFANT WITH EPILEPSY. Southwestern medicine, 1963, Volume: 44 Topics: Acetazolamide; Adrenocorticotropic Hormone; Anticonvulsants; Barbiturates; Birth Injuries; Classific	1963
ZARONTIN (ETHOSUXIMIDE) IN THE TREATMENT OF PETIT MAL AND RELATED DISORDERS. Epilepsia, 1964, Volume: 5 Topics: Adolescent; Anticonvulsants; Biomedical Research; Child; Denmark; Drug Therapy; Epilepsy; Epilepsy,	1964
[TREATMENT OF EPILEPSY WITH 3-ETHOXYCARBO-5,5-DIPHENYLHYDANTOIN (P-6127), A NEW ANTICONVULSANT]. No to shinkei = Brain and nerve, 1964, Volume: 16 Topics: Anticonvulsants; Ataxia; Blood Chemical Analysis; Drug Therapy; Electroencephalography; Epilepsy; Ep	1964
PYRIDOXINE AND INFANTILE MYOCLONIC SEIZURES. Neurology, 1965, Volume: 15 Topics: Amino Acids; Drug Therapy; Electroencephalography; Epilepsies, Myoclonic; Humans; Infant; Kynurenic	1965
Video-EEG study in an adult and a child with eyelid myoclonia with absences. Epileptic disorders : international epilepsy journal with videotape, 2004, Volume: 6, Issue:4 Topics: Adult; Anticonvulsants; Child; Dominance, Cerebral; Drug Therapy, Combination; Electroencephalograph	2004
Recurrent spontaneous myoclonus in alcohol withdrawal. Southern medical journal, 1983, Volume: 76, Issue:8 Topics: Adult; Aged; Diagnosis, Differential; Drug Therapy, Combination; Electrocardiography; Ethanol; Femal	1983
The medical treatment of tinnitus. The Journal of laryngology and otology. Supplement, 1981, Issue:4 Topics: Adult; Carbamazepine; Diethylcarbamazine; Female; Humans; Lidocaine; Myoclonus; Phenytoin; Primidone	1981
Effect of eboracin on convulsive seizures in mice: enhancement of myoclonus and inhibition of the tonic phase. Research communications in chemical pathology and pharmacology, 1982, Volume: 36, Issue:1 Topics: Acoustic Stimulation; Animals; Anticonvulsants; Electroshock; Indenes; Male; Mice; Myoclonus; Pentyl	1982
[Effect of antiepileptic agents in myoclonus of spinal origin]. Biulleten' eksperimental'noi biologii i meditsiny, 1980, Volume: 90, Issue:11 Topics: Animals; Anticonvulsants; Carbamazepine; Diazepam; Myoclonus; Phenytoin; Rats; Spinal Cord Diseases;	1980
Case report: thyrotropin-releasing hormone-induced myoclonus and tremor in a patient with Hashimoto's encephalopathy. The American journal of the medical sciences, 1995, Volume: 310, Issue:5 Topics: Adult; Female; Humans; Menstrual Cycle; Myoclonus; Phenytoin; Prolactin; Thyroid Gland; Thyroiditis,	1995
Diaphragmatic myoclonus: diagnosis by fluoroscopy and electromyography with response to phenytoin. Southern medical journal, 1995, Volume: 88, Issue:12 Topics: Adult; Diaphragm; Electromyography; Female; Fluoroscopy; Humans; Muscle Relaxants, Central; Myoclonu	1995
Treatment strategies for diaphragmatic myoclonus. Chest, 1995, Volume: 108, Issue:5 Topics: Adult; Diaphragm; Electromyography; Female; Humans; Myoclonus; Phenytoin	1995
Postural myoclonus induced by phenytoin. Clinical neuropharmacology, 1996, Volume: 19, Issue:6 Topics: Aged; Humans; Male; Myoclonus; Phenytoin; Posture; Seizures	1996
Clinical case report: multiple idiosyncratic adverse effects of antiepileptic drugs in trisomy 9p. The International journal of neuroscience, 1996, Volume: 87, Issue:3-4 Topics: Adult; Anticonvulsants; Brain; Carbamazepine; Chromosome Aberrations; Chromosome Disorders; Chromoso	1996
A primate model for testing anticonvulsant drugs. Archives of neurology, 1975, Volume: 32, Issue:5 Topics: Allyl Compounds; Animals; Anticonvulsants; Carbamazepine; Chromatography, Gas; Diazepam; Disease Mod	1975
Altered 5-HT metabolism with clonazepam, diazepam and diphenylhydantoin. The Journal of pharmacy and pharmacology, 1975, Volume: 27, Issue:9 Topics: Animals; Benzodiazepinones; Brain; Clonazepam; Diazepam; Humans; Hydroxyindoleacetic Acid; Male; Mic	1975
[Myoclonic encephalopathy caused by isoniazid-hydantoin combination]. Lille medical : journal de la Faculte de medecine et de pharmacie de l'Universite de Lille, 1979, Volume: 24, Issue:1 Topics: Brain Diseases; Drug Therapy, Combination; Female; Humans; Isoniazid; Middle Aged; Myoclonus; Phenyt	1979
Myokymia and impaired muscular relaxation with continuous motor unit activity. Journal of neurology, neurosurgery, and psychiatry, 1979, Volume: 42, Issue:6 Topics: Adult; Electromyography; Humans; Male; Middle Aged; Motor Neurons; Muscle Relaxation; Muscles; Myocl	1979
Findings in routine laboratory examination in progressive myoclonus epilepsy. Acta neurologica Scandinavica, 1975, Volume: 51, Issue:1 Topics: Adolescent; Adult; Age Factors; Blood Glucose; Blood Proteins; Cerebrospinal Fluid Proteins; Child;	1975
A neuropathological case-study of myoclonus epilepsy. Folia psychiatrica et neurologica japonica, 1976, Volume: 30, Issue:3 Topics: Adult; Brain Diseases; Cysts; Epilepsy; Humans; Male; Myoclonus; Phenytoin	1976
Familial poliodystrophy, mitochondrial myopathy, and lactate acidemia. Neurology, 1975, Volume: 25, Issue:7 Topics: Adolescent; Ataxia; Cerebral Cortex; Child; Child, Preschool; Diazepam; Diffuse Cerebral Sclerosis o	1975
[A case report of diaphragmatic flutter]. Nihon Kyobu Shikkan Gakkai zasshi, 1990, Volume: 28, Issue:5 Topics: Adolescent; Diaphragm; Electromyography; Female; Humans; Myoclonus; Phenytoin	1990
[A case of stimulus-sensitive segmental spinal myoclonus]. Rinsho shinkeigaku = Clinical neurology, 1989, Volume: 29, Issue:3 Topics: Adult; Clonazepam; Electromyography; Humans; Male; Myoclonus; Phenytoin; Physical Stimulation; Refle	1989
Asterixis: one type of negative myoclonus. Advances in neurology, 1986, Volume: 43 Topics: Brain; Electromyography; Humans; Male; Middle Aged; Myoclonus; Phenytoin; Seizures	1986
Comparison of anticonvulsive properties of eboracin and phenytoin in mice. Pharmacology, biochemistry, and behavior, 1985, Volume: 22, Issue:1 Topics: Animals; Anticonvulsants; Indenes; Lethal Dose 50; Male; Mice; Myoclonus; Pentylenetetrazole; Phenyt	1985
Stimulus-induced myoclonus and burst suppression on EEG: effects of phenytoin toxicity. Annals of neurology, 1985, Volume: 17, Issue:3 Topics: Brain Diseases; Electroencephalography; Female; Humans; Infant; Myoclonus; Phenytoin	1985
Editorial: Van Leeuwenhoek's disease. Lancet (London, England), 1974, Feb-02, Volume: 1, Issue:7849 Topics: Aged; Diaphragm; Electromyography; Hiccup; Humans; Muscle Contraction; Myoclonus; Phenytoin; Respira	1974
Clonazepam (Ro 5-4023) in the treatment of myoclonus epilepsy. Four case reports. Acta neurologica Scandinavica. Supplementum, 1973, Volume: 53 Topics: Adult; Anticonvulsants; Benzodiazepinones; Chlorobenzenes; Diazepam; Drug Therapy, Combination; Elec	1973
Death? Electroencephalography and clinical neurophysiology, 1967, Volume: 23, Issue:3 Topics: Humans; Infant; Infant Mortality; Myoclonus; Phenobarbital; Phenytoin	1967
Clonazepam in the treatment of epilepsy. The Medical journal of Australia, 1974, Jul-06, Volume: 2, Issue:1 Topics: Adult; Anticonvulsants; Benzodiazepinones; Chlorobenzenes; Chromatography, Gas; Drug Interactions; E	1974
Generalized muscular stiffness, fasciculations, and myokymia of peripheral nerve origin. Archives of neurology, 1970, Volume: 22, Issue:5 Topics: Adult; Basal Metabolism; Biopsy; Diazepam; Electromyography; Humans; Male; Muscular Diseases; Myoclo	1970
Drug treatment of convulsive disorders. The New England journal of medicine, 1972, Mar-02, Volume: 286, Issue:9 Topics: Acetazolamide; Adrenocorticotropic Hormone; Adult; Anticonvulsants; Barbiturates; Child; Diazepam; E	1972
Progressive myoclonus with epilepsy. Southern medical journal, 1972, Volume: 65, Issue:1 Topics: Adult; Child; Chlordiazepoxide; Epilepsy; Female; Humans; Inclusion Bodies; Lipidoses; Myoclonic Cer	1972
Respiratory myoclonus (Leeuwenhoek's disease). The New England journal of medicine, 1973, Dec-27, Volume: 289, Issue:26 Topics: Aged; Diagnosis, Differential; Diaphragm; Electrocardiography; Electromyography; Humans; Male; Muscl	1973
Clonazepam in the treatment of epilepsy. Proceedings of the Australian Association of Neurologists, 1973, Volume: 10, Issue:0 Topics: Adolescent; Adult; Anticonvulsants; Benzodiazepinones; Chlorobenzenes; Chromatography, Gas; Drug Int	1973
Letter: Palatal myoclonus and diphenylhydantoin therapy. The New England journal of medicine, 1974, May-09, Volume: 290, Issue:19 Topics: Aged; Cognition; Humans; Male; Myoclonus; Palate; Phenytoin; Sleep	1974
Myokymia and facial contraction in brain stem glioma. An electromyographic study. Archives of neurology, 1974, Volume: 30, Issue:6 Topics: Action Potentials; Adult; Brain Neoplasms; Carbamazepine; Diazepam; Edrophonium; Electromyography; F	1974
A case of petit mal status with myoclonus. Epilepsia, 1969, Volume: 10, Issue:3 Topics: Adult; Amnesia; Electroencephalography; Electromyography; Epilepsy, Absence; Humans; Male; Myoclonus	1969
Modification of experimental seizures and anticonvulsant efficacy by peripheral stimulation. Neurology, 1971, Volume: 21, Issue:4 Topics: Animals; Cats; Cerebral Cortex; Disease Models, Animal; Electric Stimulation; Electroencephalography	1971
Self-induced television epilepsy. Epilepsia, 1971, Volume: 12, Issue:3 Topics: Adolescent; Electroencephalography; Epilepsy; Ethosuximide; Female; Humans; Myoclonus; Phenytoin; Te	1971
Electrophysiological observations in a patient with segmental myoclonus. Proceedings of the Australian Association of Neurologists, 1969, Volume: 6 Topics: Aged; Diazepam; Electroencephalography; Electromyography; Female; Humans; Methocarbamol; Motor Neuro	1969
Anticonvulsant properties of diphenylthiohydantoin. Archives internationales de pharmacodynamie et de therapie, 1970, Volume: 188, Issue:2 Topics: Animals; Drug Antagonism; Electroencephalography; Electroshock; Hindlimb; Male; Myoclonus; Pentylene	1970
[Transitory healing of psoriaisis efflorescences during hydantoin poisoning with unusual central nervous symptoms]. Dermatologische Wochenschrift, 1968, Mar-16, Volume: 154, Issue:11 Topics: Central Nervous System Diseases; Female; Humans; Middle Aged; Myoclonus; Phenytoin; Stomatitis; Subs	1968

phenytoin and Myoclonic Jerk

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