phenytoin has been researched along with Muscle Spasticity in 11 studies
Muscle Spasticity: A form of muscle hypertonia associated with upper MOTOR NEURON DISEASE. Resistance to passive stretch of a spastic muscle results in minimal initial resistance (a free interval) followed by an incremental increase in muscle tone. Tone increases in proportion to the velocity of stretch. Spasticity is usually accompanied by HYPERREFLEXIA and variable degrees of MUSCLE WEAKNESS. (From Adams et al., Principles of Neurology, 6th ed, p54)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Selected examples from three series of isomeric (alkylthio)-1,2,4-triazoles were prepared and examined for anticonvulsant activity versus strychnine-, maximal-electroshock-, pentylenetetrazole-, and 3-mercaptopropionic-acid-induced seizures in mice." | 3.69 | 5-Aryl-3-(alkylthio)-4H-1,2,4-triazoles as selective antagonists of strychnine-induced convulsions and potential antispastic agents. ( Dalton, CR; Dudley, MW; Kane, JM; Kehne, JH; Ketteler, HJ; McCloskey, TC; Miller, FP; Ogden, AM; Senyah, Y; Staeger, MA, 1994) |
| "A young epileptic presented with spasticity as well as ataxia, diplopia and nystagmus; his serum phenytoin level was very high." | 3.66 | Spasticity due to phenytoin toxicity. ( Stark, RJ, 1979) |
| "Reduction of motor tone in spastic muscles, as well as improvement in functiional status, was observed." | 1.26 | Phenytoin and chlorpromazine in the treatment of spasticity. ( Armitage, P; Cohan, SL; Panagakos, J; Raines, A, 1980) |
| "The muscle relaxant (antispastic) effect of diazepam, alone or in combination with phenytoin, was studied in mutant Han-Wistar rats with progressive spastic paresis." | 1.26 | Interaction between phenytoin and diazepam in mutant Han-Wistar rats with progressive spastic paresis. ( Schwarz, M; Sontag, KH; Turski, L, 1982) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (63.64) | 18.7374 |
| 1990's | 3 (27.27) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (9.09) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kane, JM | 1 |
| Staeger, MA | 1 |
| Dalton, CR | 1 |
| Miller, FP | 1 |
| Dudley, MW | 1 |
| Ogden, AM | 1 |
| Kehne, JH | 1 |
| Ketteler, HJ | 1 |
| McCloskey, TC | 1 |
| Senyah, Y | 1 |
| Arai, M | 1 |
| Osaka, H | 1 |
| OKUDA, O | 1 |
| SHINOHARA, S | 1 |
| Cohan, SL | 1 |
| Raines, A | 1 |
| Panagakos, J | 1 |
| Armitage, P | 1 |
| Turski, L | 1 |
| Schwarz, M | 1 |
| Sontag, KH | 1 |
| Alonso Castell, P | 1 |
| Moreno Galdó, A | 1 |
| Sospedra Martínez, E | 1 |
| Roqueta Mas, J | 1 |
| Hidalgo Albert, E | 1 |
| Iglesias Berengué, J | 1 |
| Saito, Y | 1 |
| Hashimoto, T | 1 |
| Iwata, H | 1 |
| Takahashi, K | 1 |
| Fukumizu, M | 1 |
| Sasaki, M | 1 |
| Hanaoka, S | 1 |
| Sugai, K | 1 |
| Stark, RJ | 1 |
| Hemmy, DC | 1 |
| Larson, SJ | 1 |
| Sances, A | 1 |
| Millar, EA | 1 |
| Lennox-Buchthal, MA | 1 |
| Neville, BG | 1 |
2 reviews available for phenytoin and Muscle Spasticity
| Article | Year |
|---|---|
Apneustic breathing in children with brainstem damage due to hypoxic-ischemic encephalopathy.
Topics: Brain; Brain Diseases; Brain Ischemia; Brain Stem; Child, Preschool; Dose-Response Relationship, Dru | 1999 |
Febrile convulsions. A reappraisal.
Topics: Age Factors; Animals; Animals, Newborn; Body Temperature; Brain; Brain Damage, Chronic; Child, Presc | 1973 |
9 other studies available for phenytoin and Muscle Spasticity
| Article | Year |
|---|---|
5-Aryl-3-(alkylthio)-4H-1,2,4-triazoles as selective antagonists of strychnine-induced convulsions and potential antispastic agents.
Topics: Animals; Anticonvulsants; Cerebellum; Cerebral Cortex; Chlorides; Electroshock; Flumazenil; Male; Mi | 1994 |
Acute leukoencephalopathy possibly induced by phenytoin intoxication in an adult patient with methylenetetrahydrofolate reductase deficiency.
Topics: Anticonvulsants; Brain; Homocystinuria; Humans; Leukoencephalopathies; Magnetic Resonance Imaging; M | 2011 |
[OBSERVATION ON TWO CASES OF EPILEPSIA CURSIVA].
Topics: Adolescent; Atrophy; Barbiturates; Cerebral Cortex; Chlordiazepoxide; Dichlorphenamide; Electroencep | 1964 |
Phenytoin and chlorpromazine in the treatment of spasticity.
Topics: Adult; Aged; Chlorpromazine; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Motor Neu | 1980 |
Interaction between phenytoin and diazepam in mutant Han-Wistar rats with progressive spastic paresis.
Topics: Animals; Diazepam; Drug Interactions; Electromyography; Female; Male; Muscle Spasticity; Muscles; Pa | 1982 |
[Serious intoxication by Coriaria myrtifolia: a case study].
Topics: Child; Gastric Lavage; Humans; Male; Muscle Spasticity; Phenytoin; Plants, Toxic; Poisoning; Respira | 1997 |
Spasticity due to phenytoin toxicity.
Topics: Adult; Ataxia; Epilepsy, Tonic-Clonic; Humans; Male; Muscle Spasticity; Phenytoin; Reflex, Abnormal | 1979 |
The effect of cerebellar stimulation on focal seizure activity and spasticity in monkeys.
Topics: Animals; Cerebellar Cortex; Differential Threshold; Electric Stimulation; Evoked Potentials; Haplorh | 1977 |
The origin of infantile spasms: evidence from a case of hydranencephaly.
Topics: Anencephaly; Cerebral Ventriculography; Electroencephalography; Electromyography; Female; Humans; Hy | 1972 |