phenytoin has been researched along with Multiple Sclerosis in 21 studies
Multiple Sclerosis: An autoimmune disorder mainly affecting young adults and characterized by destruction of myelin in the central nervous system. Pathologic findings include multiple sharply demarcated areas of demyelination throughout the white matter of the central nervous system. Clinical manifestations include visual loss, extra-ocular movement disorders, paresthesias, loss of sensation, weakness, dysarthria, spasticity, ataxia, and bladder dysfunction. The usual pattern is one of recurrent attacks followed by partial recovery (see MULTIPLE SCLEROSIS, RELAPSING-REMITTING), but acute fulminating and chronic progressive forms (see MULTIPLE SCLEROSIS, CHRONIC PROGRESSIVE) also occur. (Adams et al., Principles of Neurology, 6th ed, p903)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Phenytoin is a non-sedative barbiturate derivate and has been recently rediscovered as a neuroprotective and retinoprotective compound in patients affected by optic neuritis secondary to multiple sclerosis." | 4.98 | The retinoprotective role of phenytoin. ( Bartollino, S; Chiosi, F; Costagliola, C; di Staso, S; Hesselink, JMK; Pascotto, A; Rinaldi, M; Uva, M, 2018) |
| "Classically, trigeminal neuralgia has been described as a paroxysmal, lancinating, knifelike pain which is limited to the anatomic pathways of the fifth cranial nerve." | 2.36 | Trigeminal neuralgia: an overview. ( Bayer, DB; Stenger, TG, 1979) |
| "Multiple sclerosis is a rare but not exceptional condition in children." | 1.27 | Multiple sclerosis in childhood: long term katamnestic investigations. ( Máttyus, A; Veres, E, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 17 (80.95) | 18.7374 |
| 1990's | 1 (4.76) | 18.2507 |
| 2000's | 1 (4.76) | 29.6817 |
| 2010's | 2 (9.52) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bartollino, S | 1 |
| Chiosi, F | 1 |
| di Staso, S | 1 |
| Uva, M | 1 |
| Pascotto, A | 1 |
| Rinaldi, M | 1 |
| Hesselink, JMK | 1 |
| Costagliola, C | 1 |
| Tang, X | 1 |
| Zhang, X | 1 |
| Craner, MJ | 1 |
| Damarjian, TG | 1 |
| Liu, S | 1 |
| Hains, BC | 1 |
| Lo, AC | 1 |
| Black, JA | 1 |
| Newcombe, J | 1 |
| Cuzner, ML | 1 |
| Waxman, SG | 1 |
| Skillrud, DM | 1 |
| Goldstein, NP | 1 |
| Bolden, RO | 1 |
| Felsenthal, G | 1 |
| Cohen, BS | 1 |
| Stork, CM | 1 |
| Hoffman, RS | 1 |
| Bayer, DB | 1 |
| Stenger, TG | 1 |
| Rosenthal, SH | 1 |
| Todman, DH | 1 |
| Máttyus, A | 1 |
| Veres, E | 1 |
| Gilland, O | 1 |
| Sharpe, JA | 1 |
| Shibasaki, H | 2 |
| Kuroiwa, Y | 2 |
| Yoshimasu, F | 1 |
| Kurland, LT | 1 |
| Elveback, LR | 1 |
| Haring, RD | 1 |
| Simmons, FB | 1 |
| Cendrowski, W | 1 |
| Majkowski, J | 1 |
| Weintraub, MI | 1 |
| Megahed, MS | 1 |
| Smith, BH | 1 |
| Krajca, K | 1 |
| Orolin, D | 1 |
| Rushton, JG | 1 |
| Olafson, RA | 1 |
| Roberts, HJ | 1 |
2 reviews available for phenytoin and Multiple Sclerosis
| Article | Year |
|---|---|
The retinoprotective role of phenytoin.
Topics: Antineoplastic Agents; Drug Discovery; Enzyme Inhibitors; Humans; Multiple Sclerosis; Neuroprotectiv | 2018 |
Trigeminal neuralgia: an overview.
Topics: Age Factors; Aged; Anesthetics, Local; Carbamazepine; Diagnosis, Differential; Electrocoagulation; F | 1979 |
2 trials available for phenytoin and Multiple Sclerosis
| Article | Year |
|---|---|
Painful tonic seizure in multiple sclerosis.
Topics: Adult; Animals; Brain Stem; Carbamazepine; Cerebellum; Cerebral Cortex; Clinical Trials as Topic; De | 1974 |
Painful tonic seizure in multiple sclerosis treatment with diphenylhydantoin and carbamazepine.
Topics: Adult; Carbamazepine; Dibenzazepines; Electrocardiography; Electroencephalography; Female; Humans; M | 1968 |
17 other studies available for phenytoin and Multiple Sclerosis
| Article | Year |
|---|---|
Drug-induced pemphigus after six years of treatment with phenytoin and carbamazepine.
Topics: Anticonvulsants; Carbamazepine; Female; Humans; Middle Aged; Multiple Sclerosis; Pemphigus; Phenytoi | 2012 |
Sodium channels contribute to microglia/macrophage activation and function in EAE and MS.
Topics: Animals; Axons; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Female; Gliosis | 2005 |
Paroxysmal limb hemiataxia with crossed facial paresthesias in multiple sclerosis.
Topics: Adult; Ataxia; Carbamazepine; Face; Humans; Male; Multiple Sclerosis; Paresthesia; Phenytoin; Thromb | 1983 |
Tonic seizures in a patient with multiple sclerosis.
Topics: Carbamazepine; Clonazepam; Female; Humans; Middle Aged; Multiple Sclerosis; Phenytoin; Seizures | 1980 |
Characterization of 4-aminopyridine in overdose.
Topics: 4-Aminopyridine; Adult; Drug Overdose; Female; Humans; Middle Aged; Multiple Sclerosis; Phenytoin | 1994 |
Letter: Convulsions during orgasm due to multiple sclerosis.
Topics: Adult; Female; Humans; Multiple Sclerosis; Orgasm; Phenytoin; Seizures | 1975 |
A paroxysmal ocular motility disorder in multiple sclerosis.
Topics: Adult; Carbamazepine; Diagnosis, Differential; Eye Movements; Female; Humans; Multiple Sclerosis; Op | 1988 |
Multiple sclerosis in childhood: long term katamnestic investigations.
Topics: Adolescent; Age Factors; Child; Child, Preschool; Electroencephalography; Epilepsy; Female; Humans; | 1985 |
[American neurology for Swedish use].
Topics: Adrenocorticotropic Hormone; Ampicillin; Brain Diseases; Cerebrovascular Disorders; Contrast Media; | 1968 |
Editoral: Rebound nystagmus--a cerebellar sign?
Topics: Brain Diseases; Brain Stem; Cerebellar Diseases; Cerebellar Neoplasms; Chronic Disease; Cranial Foss | 1974 |
Tic douloureux in Rochester, Minnesota, 1945-1969.
Topics: Adult; Age Factors; Aged; Analgesics; Carbamazepine; Ethanol; Female; Follow-Up Studies; Humans; Hyp | 1972 |
Cerebellar defects detectable by electronystagmography calibration.
Topics: Adolescent; Adult; Aged; Astrocytoma; Blindness; Brain Diseases; Cerebellar Ataxia; Cerebellar Disea | 1973 |
Epilepsy in multiple sclerosis.
Topics: Adolescent; Adult; Barbiturates; Basal Ganglia; Carbamazepine; Cerebral Cortex; Demyelinating Diseas | 1972 |
Myotonic-like syndrome in multiple sclerosis.
Topics: Adult; Female; Humans; Male; Multiple Sclerosis; Muscle Cramp; Myotonia; Phenytoin; Quinine; Spasm | 1970 |
[Hemitetanic syndrome in multiple sclerosis].
Topics: Adult; Blood Protein Electrophoresis; Calcium; Electroencephalography; Electromyography; Female; Hum | 1969 |
Trigeminal neuralgia associated with multiple sclerosis. A case report.
Topics: Adult; Humans; Mephenesin; Middle Aged; Multiple Sclerosis; Phenytoin; Trigeminal Neuralgia | 1965 |
An inquiry into the pathogenesis, rational treatment and prevention of multiple sclerosis, with emphasis upon the combined role of diabetogenic hyperinsulinism and recurrent edema.
Topics: Adult; Diet Therapy; Edema; Female; Glucose Tolerance Test; Humans; Hyperinsulinism; Male; Methylphe | 1966 |