phenytoin has been researched along with Melanoma in 7 studies
Melanoma: A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445)
| Excerpt | Relevance | Reference |
|---|---|---|
| "A 29-year-old white man with brain metastases secondary to malignant melanoma consistently had suboptimal phenytoin concentrations while receiving chemotherapy consisting of cisplatin, carmustine, dacarbazine, and tamoxifen." | 4.79 | Possible interaction involving phenytoin, dexamethasone, and antineoplastic agents: a case report and review. ( Gattis, WA; May, DB, 1996) |
| "The DNS II acetone fraction of Delphinium nordhagenii has exhibited the anticonvulsant actions by preventing the seizures against PTZ- and picrotoxin-induced seizure as well as 100% seizure protection in MES test." | 3.76 | Anticonvulsant activity of DNS II fraction in the acute seizure models. ( Ahmad, M; Raza, ML; Shaheen, F; Simjee, SU; Zeeshan, M, 2010) |
| "The effects of a single Phenytoin dose, given to patients with malignant melanoma, upon peripheral blood counts, serum immunoglobulins, lymphocyte subpopulations and lymphocytotoxicity (using Chang target cells) were recorded." | 3.66 | Effects of diphenylhydantoin on killer cell activity and other immunological functions. A sequential study including the interaction of Corynebacterium parvum in melanoma patients. ( Crowther, D; Swindell, R; Thatcher, N; Wan, HH; Wilkinson, PM, 1982) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (57.14) | 18.7374 |
| 1990's | 2 (28.57) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (14.29) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Raza, ML | 1 |
| Zeeshan, M | 1 |
| Ahmad, M | 1 |
| Shaheen, F | 1 |
| Simjee, SU | 1 |
| Thatcher, N | 2 |
| Wan, HH | 2 |
| Swindell, R | 1 |
| Wilkinson, PM | 2 |
| Crowther, D | 1 |
| Gattis, WA | 1 |
| May, DB | 1 |
| Mullen, PW | 1 |
| Smith, GN | 1 |
| Ghosh, C | 1 |
| Lazarus, HM | 1 |
| Hewlett, JS | 1 |
| Creger, RJ | 1 |
| Dorfman, RF | 1 |
| Warnke, R | 1 |
2 reviews available for phenytoin and Melanoma
| Article | Year |
|---|---|
Possible interaction involving phenytoin, dexamethasone, and antineoplastic agents: a case report and review.
Topics: Adult; Anticonvulsants; Antineoplastic Agents; Brain Neoplasms; Dexamethasone; Drug Interactions; Hu | 1996 |
Lymphadenopathy simulating the malignant lymphomas.
Topics: Animals; Biopsy; Dermatitis; Drug Hypersensitivity; Herpes Zoster; Humans; Hyalin; Hyperplasia; Infe | 1974 |
1 trial available for phenytoin and Melanoma
| Article | Year |
|---|---|
Fluctuation of serum phenytoin concentrations during autologous bone marrow transplant for primary central nervous system tumors.
Topics: Adult; Anticonvulsants; Astrocytoma; Bone Marrow Transplantation; Brain Neoplasms; Carbamazepine; Fe | 1992 |
4 other studies available for phenytoin and Melanoma
| Article | Year |
|---|---|
Anticonvulsant activity of DNS II fraction in the acute seizure models.
Topics: Acetone; Animals; Anticonvulsants; Delphinium; Diazepam; Epilepsy; Male; Melanoma; Mice; Mice, Inbre | 2010 |
Effects of diphenylhydantoin on killer cell activity and other immunological functions. A sequential study including the interaction of Corynebacterium parvum in melanoma patients.
Topics: Bacterial Vaccines; Cytotoxicity, Immunologic; Female; Humans; Immunoglobulin G; Immunotherapy; Kill | 1982 |
Lack of effect of immunotherapy with BCG and Corynebacterium parvum on hepatic drug hydroxylation in man.
Topics: Adenocarcinoma; Adult; Aged; Bacterial Vaccines; BCG Vaccine; Female; Humans; Immunotherapy; Kidney | 1979 |
Immune mechanisms in cancer.
Topics: Animals; Antibodies, Neoplasm; Antigen-Antibody Complex; Antigens, Neoplasm; Humans; Immunity, Cellu | 1973 |