Page last updated: 2024-10-21

phenytoin and Lymphoma

phenytoin has been researched along with Lymphoma in 57 studies

Lymphoma: A general term for various neoplastic diseases of the lymphoid tissue.

Research Excerpts

ExcerptRelevanceReference
"We report a patient with phenytoin-induced pseudolymphoma mimicking cutaneous T-cell lymphoma (CTCL)."8.78Phenytoin-induced pseudolymphoma. A report of a case and review of the literature. ( Buckley, C; Harris, DW; Ostlere, L; Rustin, MH; Sweny, P; Whittaker, S, 1992)
"Patients receiving phenytoin (PHT) may develop pseudolymphoma or, rare ly, malignant lymphoma."7.69Phenytoin-induced pseudolymphoma: reevaluation using modern molecular biology techniques. ( Jeng, YM; Su, IJ; Tien, HF, 1996)
"A pseudolymphomatous reaction involving subcutaneous tissue and underlying skeletal muscle is described in a woman who was receiving phenytoin sodium and phenobarbitone."7.66A pseudolymphomatous reaction in soft tissue associated with phenytoin sodium. ( Scott, CA; Wilden, JN, 1978)
"In vitro and in vivo immunologic studies were performed on a 28-year-old woman with phenytoin sodium-induced pseudolymphoma syndrome."7.65Phenytoin-induced pseudolymphoma syndrome: an immunologic study. ( Charlesworth, EN, 1977)
"We report a patient with phenytoin-induced pseudolymphoma mimicking cutaneous T-cell lymphoma (CTCL)."4.78Phenytoin-induced pseudolymphoma. A report of a case and review of the literature. ( Buckley, C; Harris, DW; Ostlere, L; Rustin, MH; Sweny, P; Whittaker, S, 1992)
" Using a PEG 3350 screen combined with detergents, and developed from our experiments with an IgG2a kappa antibody specific for canine lymphoma cells, crystals have now been obtained of two of these four immunoglobulins, an antiphenytoin and an antiphenobarbital antibody."3.69Crystallization of intact monoclonal antibodies. ( Harris, LJ; McPherson, A; Skaletsky, E, 1995)
"Patients receiving phenytoin (PHT) may develop pseudolymphoma or, rare ly, malignant lymphoma."3.69Phenytoin-induced pseudolymphoma: reevaluation using modern molecular biology techniques. ( Jeng, YM; Su, IJ; Tien, HF, 1996)
"A pseudolymphomatous reaction involving subcutaneous tissue and underlying skeletal muscle is described in a woman who was receiving phenytoin sodium and phenobarbitone."3.66A pseudolymphomatous reaction in soft tissue associated with phenytoin sodium. ( Scott, CA; Wilden, JN, 1978)
"In vitro and in vivo immunologic studies were performed on a 28-year-old woman with phenytoin sodium-induced pseudolymphoma syndrome."3.65Phenytoin-induced pseudolymphoma syndrome: an immunologic study. ( Charlesworth, EN, 1977)
"Decreased libido and impotence were more common in patients given primidone."2.66Comparison of carbamazepine, phenobarbital, phenytoin, and primidone in partial and secondarily generalized tonic-clonic seizures. ( Browne, TR; Collins, JF; Cramer, JA; Delgado-Escueta, AV; Mattson, RH; McCutchen, CB; McNamara, JO; Smith, DB; Treiman, DM; Williamson, PD, 1985)
"Carbamazepine was given to 15 patients, phenytoin to 12, and barbiturate to 7, respectively; 42 patients also received corticosteroids."1.30Late radiation toxicity after whole brain radiotherapy: the influence of antiepileptic drugs. ( Leicht, A; Motaref, B; Nestle, U; Nieder, C; Niewald, M; Schnabel, K, 1999)
"Phenytoin is a hydantoin-type anticonvulsive agent used extensively for nearly sixty years in the prophylactic treatment of grand mal and psychomotor seizures."1.29Perspective on the carcinogenic potential of phenytoin based on rodent tumor bioassays and human epidemiological data. ( de la Iglesia, FA; Dethloff, LA; Goldenthal, E; Gough, A; Graziano, MJ, 1996)
"An initial diagnosis of malignant lymphoma was made, and recurrent hospitalizations and treatment with cytotoxic drugs ensued."1.27Phenytoin-induced lymphadenopathy. ( Howrie, DL; Schwinghammer, TL, 1983)
"Phenytoin therapy was associated with low immunoglobulin A (21%), failure of antibody response to Salmonella typhi antigen (9%), absence of delayed hypersensitivity (D."1.25Depression of immunological function in patients treated with phenytoin sodium (sodium diphenylhydantoin). ( Burness, FR; Forbes, IJ; Rischbieth, RH; Sorrell, TC, 1971)

Research

Studies (57)

TimeframeStudies, this research(%)All Research%
pre-199044 (77.19)18.7374
1990's10 (17.54)18.2507
2000's2 (3.51)29.6817
2010's1 (1.75)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
ROSENFELD, S1
SWILLER, AI1
SHENOY, YM1
MORRISON, AN1
Scheinfeld, N1
Lee, KC1
Garcia, PA1
Alldredge, BK1
Duggan, MA1
Court, JB1
Amadori, G1
Fiore, D1
Gabryś, K1
Medraś, E1
Kowalski, P1
Gola, A1
Isobe, T1
Tomita, M1
Matsumoto, J1
Itoh, T1
Fujita, T1
Schwinghammer, TL1
Howrie, DL1
Matoba, K1
Katsumata, T1
Kakei, M1
Kuwata, H1
Nakazawa, H1
Saigeni, K1
Okabe, H1
Chin, S1
Maekawa, K1
Katsuoka, K1
Oh-Ida, M1
Atari, H1
Rosenthal, CJ1
Noguera, CA1
Coppola, A1
Kapelner, SN1
Bedros, AA1
Mann, JP1
Adams, JD1
Vellucci, A1
Galanti, G1
Pezzella, B1
De Longis, P1
Colacecchi, C1
Abbondazo, SL1
Irey, NS1
Frizzera, G1
Sigal, M1
Pulik, M1
Harris, LJ1
Skaletsky, E1
McPherson, A1
Jeng, YM1
Tien, HF1
Su, IJ1
Dethloff, LA1
Graziano, MJ1
Goldenthal, E1
Gough, A1
de la Iglesia, FA1
Nieder, C1
Leicht, A1
Motaref, B1
Nestle, U1
Niewald, M1
Schnabel, K1
Gleichmann, E1
van Elven, F1
Gleichmann, H1
Lapes, MJ1
Vivacqua, RJ1
Antoniades, K1
Halevy, S1
Feuerman, EJ1
Bedoya, V1
Krueger, GR2
Bedoya, VA1
Matsuo, T1
Matsumoto, A1
Miyasaki, K1
Wilden, JN1
Scott, CA1
Lorand, IG1
Hadler, WA1
Prigenzi, LS1
Charlesworth, EN1
Bluming, AZ1
Li, FP1
Willard, DR1
Goodman, R1
Vawter, G1
Fried, MP1
Sunwoo, Y1
Ghosh, C1
Lazarus, HM1
Hewlett, JS1
Creger, RJ1
Harris, DW1
Ostlere, L1
Buckley, C1
Whittaker, S1
Sweny, P1
Rustin, MH1
Tittle, TV1
Schaumann, BA1
Rainey, JE1
Taylor, K1
Rodríguez-García, JL1
Sánchez-Corral, J1
Martínez, J1
Bellas, C1
Aguado, M1
Serrano, M1
Cooke, LE1
Hardin, TC1
Hendrickson, DJ1
DeSwarte, RD1
Brodell, RT1
Santa Cruz, DJ1
Mattson, RH1
Cramer, JA1
Collins, JF1
Smith, DB1
Delgado-Escueta, AV1
Browne, TR1
Williamson, PD1
Treiman, DM1
McNamara, JO1
McCutchen, CB1
Pereira, A1
Cervantes, F1
Rozman, C1
Krüger, G1
Kruger, GR1
Harris, D1
Dorfman, RF1
Warnke, R1
Sorrell, TC1
Forbes, IJ1
Burness, FR1
Rischbieth, RH1
Sisca, TS1
Fraumeni, JF1
Miller, RW1
Kopec, M1
Krasznai, G1
Szegedi, G1
Hyman, GA1
Sommers, SC1
Oates, RK1
Tonge, RE1
Alberto, P1
Cougn, R1
Maurice, P1
Weber, J1
Bercel, NA1
Henstell, HH1
Choovivathanavanich, P1
Wallace, EM1
Scaglione, PR1
Gams, RA1
Schreiber, MM1
McGregor, JG1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
An Open Prospective Randomised Long-Term Effectiveness Study, Comparing Best Medical Practice With or Without Adjunctive VNS Therapy in Patients 16 Years and Older With Pharmaco-resistant Partial Epilepsy[NCT00522418]Phase 4122 participants (Actual)Interventional2006-02-28Terminated (stopped due to Insufficient enrollment)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Change From Baseline in Adverse Event Profile (AEP) Score

Adverse Events Profile (AEP) is a 19-item scale used as a systematic measure of adverse effects from antiepileptic drugs (AEDs). Scores range from 19-76; higher scores indicate high prevelance and severity of adverse events. (NCT00522418)
Timeframe: Mean change from baseline AEP Score at 12 months

InterventionUnits on a scale (Mean)
VNS Therapy-6.0
Best Medical Practice-3.2

Change From Baseline in Center for Epidemiologic Studies Depression Scale (CES-D) Score

The Center for Epidemiologic Studies Depression Scale (CES-D) includes 20 items comprising six scales reflecting major dimensions of depression: depressed mood, feelings of guilt and worthlessness, feelings of helplessness and hopelessness, psychomotor retardation, loss of appetite, and sleep disturbance. Possible range of scores is 0 to 60, higher scores indicate more depressive symptoms. (NCT00522418)
Timeframe: Mean change from baseline CES-D Score at 12 months

InterventionUnits on a Scale (Mean)
VNS Therapy-2.2
Best Medical Practice0.5

Change From Baseline in Neurological Disorders Depression Inventory for Epilepsy (NDDI-E) Score

The Neurological Disorders Depression Inventory for Epilepsy (NDDI-E) is a 6-item questionnaire validated to screen for depression in people with epilepsy. Scores range from 6 to 24, with higher scores indicating more depressive symptoms. (NCT00522418)
Timeframe: Mean change from baseline NDDI-E Score at 12 months

InterventionUnits on a Scale (Mean)
VNS Therapy-1.0
Best Medical Practice-0.2

Changes in Anti-epileptic Drugs (AEDs)

Change from baseline in number of AED medications by visit (NCT00522418)
Timeframe: Change from baseline in number of AEDs at 12 months

InterventionNumber of AEDs Taken (Median)
VNS Therapy0
Best Medical Practice0

Mean Change From Beginning of Intervention Clinical Global Impression-Improvement Scale (CGI-I) Score at 12 Months

The Clinical Global Impression scale (CGI-I) is a 7 point scale that requires the clinician to assess how much the patient's illness has improved or worsened relative to a baseline state at the beginning of the intervention Scores range from 1-7: 1, very much improved; 2, much improved; 3, minimally improved; 4, no change; 5, minimally worse; 6, much worse; or 7, very much worse. (NCT00522418)
Timeframe: Mean change from baseline CGI-I Score at 12 months

InterventionUnits on a Scale (Mean)
VNS Therapy-0.8
Best Medical Practice-0.3

Mean Percent Change in Seizure Frequency

Percent change in total seizuires per week from baseline at 12 months (NCT00522418)
Timeframe: Mean percent change from baseline in seizure frequency at 12 months

InterventionPercent Change (Mean)
VNS Therapy-19.1
Best Medical Practice-1.0

Overall Quality of Life in Epilepsy-89 (QOLIE-89) Score in Patients With Baseline & at Least One Post-baseline QOLIE Assessment

QOLIE-89 contains 17 multi-item measures of overall quality of life, emotional well-being, role limitations due to emotional problems, social support, social isolation, energy/fatigue, worry about seizure, medication effects, health discouragement, work/driving/social function, attention/concentration, language, memory, physical function, pain, role limitations due to physical problems, and health perceptions. Range of values 0-100. Higher scores reflect better quality of life; lower ones, worse quality of life. (NCT00522418)
Timeframe: Mean change from baseline QOLIE-89 Overall Score at 12 months

Interventionunits on a scale (Mean)
VNS Therapy5.5
Best Medical Practice1.2

Response Rate

Response Rate is defined as the percent of participants who are responders. A Responder is defined as participants with a reduction of at least 50% or 75% in seizure frequency from baseline to the seizure count evaluation period. (NCT00522418)
Timeframe: Number of Responders at 12 Months

Interventionparticipants (Number)
VNS Therapy10
Best Medical Practice7

Change From Baseline in QOLIE-89 Measures: Subgroup Analysis of Population With Baseline Adverse Event Profile Score < 40

QOLIE-89 contains 17 multi-item measures of overall quality of life. Range of values 0-100. Higher scores reflect better quality of life; lower ones, worse quality of life. Adverse Events Profile (AEP) is a 19-item scale used as a systematic measure of adverse effects from antiepileptic drugs (AEDs). Scores range from 19-76; higher scores indicate high prevelance and severity of adverse events. (NCT00522418)
Timeframe: Change from baseline up to 12 months

Interventionunits on a scale (Least Squares Mean)
VNS TherapyBest Medical Practice
Baseline Adverse Event Profile Score < 403.30.5

Change From Baseline in QOLIE-89 Measures: Subgroup Analysis of Population With Baseline Adverse Event Profile Score >= 40

QOLIE-89 contains 17 multi-item measures of overall quality of life. Range of values 0-100. Higher scores reflect better quality of life; lower ones, worse quality of life. Adverse Events Profile (AEP) is a 19-item scale used as a systematic measure of adverse effects from antiepileptic drugs (AEDs). Scores range from 19-76; higher scores indicate high prevelance and severity of adverse events. (NCT00522418)
Timeframe: Change from baseline up to 12 months

InterventionUnits on a Scale (Least Squares Mean)
VNS TherapyBest Medical Practice
Baseline Adverse Event Profile Score >= 403.30.7

Reviews

10 reviews available for phenytoin and Lymphoma

ArticleYear
Impact of phenytoin therapy on the skin and skin disease.
    Expert opinion on drug safety, 2004, Volume: 3, Issue:6

    Topics: Abnormalities, Drug-Induced; Adult; Anticonvulsants; Child; Connective Tissue Diseases; Drug Eruptio

2004
Lymphadenopathy in children.
    Advances in pediatrics, 1981, Volume: 28

    Topics: Adolescent; Autoimmune Diseases; Biopsy; Child; Child, Preschool; Head; Hodgkin Disease; Humans; Hyp

1981
[Drug-induced pseudolymphoma with predominantly cutaneous manifestation].
    Annales de dermatologie et de venereologie, 1993, Volume: 120, Issue:2

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anticonvulsants; Carbamazepine; Female; France; Humans;

1993
Phenytoin-induced pseudolymphoma. A report of a case and review of the literature.
    The British journal of dermatology, 1992, Volume: 127, Issue:4

    Topics: Adult; Diagnosis, Differential; Humans; Lymphoma; Lymphoma, T-Cell, Cutaneous; Male; Phenytoin

1992
Drug allergy: an overview.
    Clinical reviews in allergy, 1986, Volume: 4, Issue:2

    Topics: Anaphylaxis; Anemia; Boston; Desensitization, Immunologic; Drug Hypersensitivity; Fever; Humans; Liv

1986
Cutaneous pseudolymphomas.
    Dermatologic clinics, 1985, Volume: 3, Issue:4

    Topics: Diagnosis, Differential; Humans; Hyperplasia; Immunoblastic Lymphadenopathy; Lymphocytes; Lymphoma;

1985
Lymphadenopathy simulating the malignant lymphomas.
    Human pathology, 1974, Volume: 5, Issue:5

    Topics: Animals; Biopsy; Dermatitis; Drug Hypersensitivity; Herpes Zoster; Humans; Hyalin; Hyperplasia; Infe

1974
Drug-induced cancer.
    Journal of the National Cancer Institute, 1972, Volume: 48, Issue:5

    Topics: Alkylating Agents; Animals; Carcinogens; Diethylstilbestrol; Drug-Related Side Effects and Adverse R

1972
[New data evidencing the role of antigenic stimulation in the pathogenesis of neoplasms of the lymphatic and plasmocytic systems. I. Can drug-induced hypersensitivity reactions lead to neoplastic proliferation in the lymphatic system?].
    Polskie Archiwum Medycyny Wewnetrznej, 1972, Volume: 49, Issue:3

    Topics: Adjuvants, Immunologic; Antigens, Neoplasm; Antistreptolysin; Diagnosis, Differential; Drug Hypersen

1972
[Lymphadenopathies caused by drugs].
    Orvosi hetilap, 1969, Nov-30, Volume: 110, Issue:48

    Topics: Adolescent; Adult; Animals; Carcinogens; Female; Humans; Lymph Nodes; Lymphatic Diseases; Lymphoma;

1969

Trials

2 trials available for phenytoin and Lymphoma

ArticleYear
Fluctuation of serum phenytoin concentrations during autologous bone marrow transplant for primary central nervous system tumors.
    Journal of neuro-oncology, 1992, Volume: 12, Issue:1

    Topics: Adult; Anticonvulsants; Astrocytoma; Bone Marrow Transplantation; Brain Neoplasms; Carbamazepine; Fe

1992
Comparison of carbamazepine, phenobarbital, phenytoin, and primidone in partial and secondarily generalized tonic-clonic seizures.
    The New England journal of medicine, 1985, Jul-18, Volume: 313, Issue:3

    Topics: Adolescent; Adult; Aged; Carbamazepine; Clinical Trials as Topic; Double-Blind Method; Epilepsies, P

1985

Other Studies

45 other studies available for phenytoin and Lymphoma

ArticleYear
Phenytoin and phenytoin sodium.
    Report on carcinogens : carcinogen profiles, 2011, Volume: 12

    Topics: Animals; Anticonvulsants; Carcinogens; Humans; Leukemia; Lymphoma; Phenytoin; Sodium

2011
Syndrome simulatingqymphosarcoma induced by diphenylhydantoin sodium.
    JAMA, 1961, May-13, Volume: 176

    Topics: Disease; Humans; Hydantoins; Lymph Nodes; Lymphatic Diseases; Lymphoma; Lymphoma, Non-Hodgkin; Pheny

1961
Clinical features of status epilepticus in patients with HIV infection.
    Neurology, 2005, Jul-26, Volume: 65, Issue:2

    Topics: Adult; Anti-Retroviral Agents; Anticonvulsants; Benzodiazepines; Brain Neoplasms; Central Nervous Sy

2005
A proposed mechanism of production of the autoimmune and lymphoproliferative side-effects of beta-adrenergic-site-blocking drugs and hydantoin anticonvulsants.
    Annals of clinical research, 1981, Volume: 13, Issue:6

    Topics: Adrenergic beta-Antagonists; Animals; Autoimmune Diseases; Carcinogens; Cyclic AMP; Ethanolamines; F

1981
[Diagnostic problems in hydantoin immunopathy. Review of the literature and description of 3 cases].
    Minerva medica, 1984, Nov-03, Volume: 75, Issue:42

    Topics: Adolescent; Adult; Female; Fluorescent Antibody Technique; Humans; Immunoblastic Lymphadenopathy; Ki

1984
[Development of malignant lymphoma during anticonvulsant therapy].
    Polski tygodnik lekarski (Warsaw, Poland : 1960), 1983, Apr-18, Volume: 38, Issue:16

    Topics: Epilepsy; Gastrointestinal Neoplasms; Humans; Lung Neoplasms; Lymphoma; Male; Middle Aged; Phenytoin

1983
Hematologic and immunologic aberrations in patients under diphenylhydantoin administration.
    Nihon Ketsueki Gakkai zasshi : journal of Japan Haematological Society, 1983, Volume: 46, Issue:1

    Topics: Adolescent; Aged; Anticonvulsants; Arthritis, Rheumatoid; Female; Humans; Infectious Mononucleosis;

1983
Phenytoin-induced lymphadenopathy.
    Drug intelligence & clinical pharmacy, 1983, Volume: 17, Issue:6

    Topics: Humans; Lymph Nodes; Lymphatic Diseases; Lymphoma; Male; Middle Aged; Phenytoin

1983
[A case of primary B-cell origin lymphoma of the stomach seen during diphenylhydantoin therapy (author's transl)].
    Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology, 1981, Volume: 78, Issue:9

    Topics: Adult; B-Lymphocytes; Female; Humans; Lymphoma; Phenytoin; Stomach Neoplasms

1981
Pseudolymphoma with mycosis fungoides manifestations, hyperresponsiveness to diphenylhydantoin, and lymphocyte disregulation.
    Cancer, 1982, Jun-01, Volume: 49, Issue:11

    Topics: Adolescent; Adult; B-Lymphocytes; Female; Humans; Lymphoma; Male; Microscopy, Electron; Middle Aged;

1982
Localized cutaneous pseudolymphoma associated with phenytoin therapy: a case report.
    The Australasian journal of dermatology, 1981, Volume: 22, Issue:1

    Topics: Child; Female; Humans; Lymphoma; Phenytoin; Skin Neoplasms

1981
[Case of "exanthematous pseudolymphoma" due to diphenylhydantoin hypersensitivity with a transitory immunologic deficit].
    La Clinica terapeutica, 1980, Jul-31, Volume: 94, Issue:2

    Topics: Adolescent; Drug Hypersensitivity; Exanthema; Humans; Immunologic Deficiency Syndromes; Lymphoma; Ma

1980
Dilantin-associated lymphadenopathy. Spectrum of histopathologic patterns.
    The American journal of surgical pathology, 1995, Volume: 19, Issue:6

    Topics: Adult; Aged; Female; Humans; Hyperplasia; Immunophenotyping; Lymphatic Diseases; Lymphoma; Male; Mid

1995
Crystallization of intact monoclonal antibodies.
    Proteins, 1995, Volume: 23, Issue:2

    Topics: Animals; Antibodies, Monoclonal; Antibodies, Neoplasm; Antibody Specificity; Crystallization; Crysta

1995
Phenytoin-induced pseudolymphoma: reevaluation using modern molecular biology techniques.
    Epilepsia, 1996, Volume: 37, Issue:1

    Topics: Adolescent; Biopsy; Blotting, Southern; Chromosome Aberrations; Diagnosis, Differential; Epilepsy, T

1996
Perspective on the carcinogenic potential of phenytoin based on rodent tumor bioassays and human epidemiological data.
    Human & experimental toxicology, 1996, Volume: 15, Issue:4

    Topics: Animals; Anticonvulsants; Carcinogenicity Tests; Dose-Response Relationship, Drug; Female; Humans; L

1996
Late radiation toxicity after whole brain radiotherapy: the influence of antiepileptic drugs.
    American journal of clinical oncology, 1999, Volume: 22, Issue:6

    Topics: Actuarial Analysis; Adult; Aged; Aged, 80 and over; Analysis of Variance; Anticonvulsants; Atrophy;

1999
Immunoblastic lymphadenopathy, systemic lupus erythematosus, and related disorders. Possible pathogenetic pathways.
    American journal of clinical pathology, 1979, Volume: 72, Issue:4 Suppl

    Topics: Animals; Autoantibodies; B-Lymphocytes; Drug Hypersensitivity; Graft vs Host Reaction; Humans; Immun

1979
Letter: Immunoblactic lymphadenopathy associated with phenytoin (diphenylhydantoin).
    Lancet (London, England), 1976, Jan-24, Volume: 1, Issue:7952

    Topics: Aged; Antibody-Producing Cells; Female; Humans; Lymphocytes; Lymphoma; Phenytoin

1976
Psuedolymphoma syndrome.
    Dermatologica, 1977, Volume: 155, Issue:6

    Topics: Diagnosis, Differential; Drug Eruptions; Humans; Lymphoma; Male; Middle Aged; Phenytoin; Skin; Skin

1977
Ultrastructural studies on hydantoin induced lymphomas in mice.
    Zeitschrift fur Krebsforschung und klinische Onkologie. Cancer research and clinical oncology, 1978, May-31, Volume: 91, Issue:2

    Topics: Animals; Female; Hydantoins; Lymphoma; Mice; Phenytoin

1978
Hydantoin-induced lymphadenopathies and lymphomas: experimental studies in mice.
    Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer, 1978, Volume: 64

    Topics: Animals; Female; Immunoblastic Lymphadenopathy; Lymphoma; Lymphoma, Non-Hodgkin; Mice; Mice, Inbred

1978
[A case of diphenylhydantoin-induced pseudo-pseudolymphoma (author's transl)].
    Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine, 1977, Mar-10, Volume: 66, Issue:3

    Topics: Diagnosis, Differential; Female; Humans; Lymphoma; Middle Aged; Phenytoin

1977
A pseudolymphomatous reaction in soft tissue associated with phenytoin sodium.
    Journal of clinical pathology, 1978, Volume: 31, Issue:8

    Topics: Adult; Female; Humans; Lymphoma; Muscles; Phenytoin; Soft Tissue Neoplasms

1978
Morphological changes in the lymphoid organs induced by diphenylhydantoin sodium (DPH).
    Virchows Archiv. A, Pathological anatomy and histology, 1976, Nov-22, Volume: 372, Issue:1

    Topics: Animals; Female; Lymph Nodes; Lymphoid Tissue; Lymphoma; Organ Size; Phenytoin; Plasma Cells; Rats;

1976
Phenytoin-induced pseudolymphoma syndrome: an immunologic study.
    Archives of dermatology, 1977, Volume: 113, Issue:4

    Topics: Adult; Antibody Formation; Drug Hypersensitivity; Epilepsy; Female; Humans; Hypersensitivity, Delaye

1977
Spontaneous regression of sarcoma.
    National Cancer Institute monograph, 1976, Volume: 44

    Topics: B-Lymphocytes; Diagnosis, Differential; Humans; Hyperthyroidism; Immunosuppression Therapy; Infectio

1976
Malignant lymphoma after diphenylhydantoin (dilantin) therapy.
    Cancer, 1975, Volume: 36, Issue:4

    Topics: Adult; Female; Hodgkin Disease; Humans; Lymphoma; Male; Middle Aged; Phenytoin

1975
Anticonvulsant-induced lymphoma.
    The Laryngoscope, 1975, Volume: 85, Issue:10

    Topics: Adult; Head and Neck Neoplasms; Humans; Lymphoma; Phenytoin; Vocal Cord Paralysis

1975
Segregation of the growth slowing effects of valproic acid from phenytoin and carbamazepine on lymphoid tumor cells.
    Life sciences, 1992, Volume: 50, Issue:14

    Topics: Carbamazepine; Cell Division; Culture Techniques; Humans; Kinetics; Leukemia; Lymphoma; Phenytoin; R

1992
Phenytoin-induced benign lymphadenopathy with solid spleen lesions mimicking a malignant lymphoma.
    Annals of oncology : official journal of the European Society for Medical Oncology, 1991, Volume: 2, Issue:6

    Topics: Aged; Aged, 80 and over; Diagnosis, Differential; Female; Humans; Lymphatic Diseases; Lymphoma; Phen

1991
Phenytoin-induced pseudolymphoma with mycosis fungoides manifestations.
    Clinical pharmacy, 1988, Volume: 7, Issue:2

    Topics: Adult; Humans; Lymphoma; Male; Mycosis Fungoides; Phenytoin; Skin Neoplasms

1988
[Macrocytic anemia due to folic acid deficiency and non-Hodgkin's lymphoma associated with prolonged diphenylhydantoin ingestion].
    Medicina clinica, 1985, Oct-19, Volume: 85, Issue:12

    Topics: Aged; Anemia, Macrocytic; Epilepsy; Female; Folic Acid Deficiency; Humans; Lymphoma; Phenytoin; Time

1985
[Pathogenesis of lymphoreticular neoplasms in transplant recipients].
    Verhandlungen der Deutschen Gesellschaft fur Pathologie, 1970, Volume: 54

    Topics: Animals; Antilymphocyte Serum; Cell Transformation, Neoplastic; Histocompatibility; Humans; Immunosu

1970
Is phenytoin carcinogenic?
    Lancet (London, England), 1971, Nov-13, Volume: 2, Issue:7733

    Topics: Carcinogens; Cell Transformation, Neoplastic; Epilepsy; Humans; Lymphatic Diseases; Lymphoma; Phenyt

1971
Is phenytoin carcinogenic?
    Lancet (London, England), 1972, Feb-05, Volume: 1, Issue:7745

    Topics: Animals; Female; Lymphoma; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Non-Hodgkin; Mice; Mice, Inbre

1972
Depression of immunological function in patients treated with phenytoin sodium (sodium diphenylhydantoin).
    Lancet (London, England), 1971, Dec-04, Volume: 2, Issue:7736

    Topics: Adolescent; Adult; Aged; Antibody Formation; Antigens, Bacterial; Child; Epilepsy; Hodgkin Disease;

1971
An unusual dual hypersensitivity reaction induced by diphenylhydantoin.
    American journal of hospital pharmacy, 1973, Volume: 30, Issue:5

    Topics: Dermatitis, Exfoliative; Drug Hypersensitivity; Female; Humans; Leukocyte Count; Lymphoma; Middle Ag

1973
The development of Hodgkin's disease and lymphoma during anticonvulsant therapy.
    Blood, 1966, Volume: 28, Issue:3

    Topics: Adult; Aged; Anticonvulsants; Child; Epilepsy; Epilepsy, Absence; Epilepsy, Post-Traumatic; Epilepsy

1966
Phenytoin and the pseudolymphoma syndrome.
    The Medical journal of Australia, 1971, Aug-14, Volume: 2, Issue:7

    Topics: Child, Preschool; Diagnosis, Differential; Humans; Lymphatic Diseases; Lymphoma; Male; Phenytoin; Sk

1971
[3 cases of malignant lymphoma or pseudolymphoma in epileptics treated with diphenylhydantoin].
    Schweizerische medizinische Wochenschrift, 1971, Dec-11, Volume: 101, Issue:49

    Topics: Adult; Epilepsy; Female; Hodgkin Disease; Humans; Lymphoma; Male; Phenytoin

1971
The relationship between some anticonvulsants and tumors of the blood forming organs.
    Bulletin of the Los Angeles neurological societies, 1970, Volume: 35, Issue:1

    Topics: Adult; Agranulocytosis; Anticonvulsants; Female; Genetics, Medical; Humans; Hydantoins; Leukocytes;

1970
Pseudolymphoma induced by diphenylhydantoin.
    The Journal of pediatrics, 1970, Volume: 76, Issue:4

    Topics: Child; Epilepsy; Humans; Lymphoma; Male; Phenytoin; Skull Fractures

1970
Pseudolymphoma induced by diphenylhydantoin.
    The Journal of pediatrics, 1970, Volume: 77, Issue:6

    Topics: Epilepsy; Humans; Lymphoma; Phenytoin

1970
Pseudolymphoma syndrome. A sensitivity to anticonvulsant drugs.
    Archives of dermatology, 1968, Volume: 97, Issue:3

    Topics: Biopsy; Blood Cell Count; Blood Chemical Analysis; Chlordiazepoxide; Drug Hypersensitivity; Female;

1968