phenytoin has been researched along with Liver Neoplasms in 11 studies
Liver Neoplasms: Tumors or cancer of the LIVER.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The prediction of drug-drug interactions mediated by the induction or inhibition of cytochrome P450 enzymes is of great relevance in the development of new drugs." | 1.40 | HepaRG cell line as an in vitro model for screening drug-drug interactions mediated by metabolic induction: amiodarone used as a model substance. ( Alves, G; Falcão, A; Ferreira, A; Rodrigues, M; Silvestre, S, 2014) |
| "Phenytoin is a hydantoin-type anticonvulsive agent used extensively for nearly sixty years in the prophylactic treatment of grand mal and psychomotor seizures." | 1.29 | Perspective on the carcinogenic potential of phenytoin based on rodent tumor bioassays and human epidemiological data. ( de la Iglesia, FA; Dethloff, LA; Goldenthal, E; Gough, A; Graziano, MJ, 1996) |
| "(3) A human hepatoma cell line (Hep G2) was studied to obtain information on the inducibility of human UDP-GT activities by 3-methylcholanthrene-type inducers." | 1.27 | Differential induction of human liver UDP-glucuronosyltransferase activities by phenobarbital-type inducers. ( Bock, KW; Bock-Hennig, BS, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (45.45) | 18.7374 |
| 1990's | 3 (27.27) | 18.2507 |
| 2000's | 1 (9.09) | 29.6817 |
| 2010's | 2 (18.18) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ferreira, A | 1 |
| Rodrigues, M | 1 |
| Silvestre, S | 1 |
| Falcão, A | 1 |
| Alves, G | 1 |
| Hung, DZ | 1 |
| Lin, CL | 1 |
| Li, YW | 1 |
| Lin, YN | 1 |
| Lee, YR | 1 |
| Wang, CN | 1 |
| Chen, JJ | 1 |
| Lim, YP | 1 |
| Trubetskoy, O | 1 |
| Marks, B | 1 |
| Zielinski, T | 1 |
| Yueh, MF | 1 |
| Raucy, J | 1 |
| Olsen, JH | 1 |
| Schulgen, G | 1 |
| Boice, JD | 1 |
| Whysner, J | 1 |
| Travis, LB | 1 |
| Williams, GM | 1 |
| Johnson, FB | 1 |
| McGee, JO | 1 |
| Diwan, BA | 1 |
| Henneman, JR | 1 |
| Nims, RW | 1 |
| Rice, JM | 1 |
| Dethloff, LA | 1 |
| Graziano, MJ | 1 |
| Goldenthal, E | 1 |
| Gough, A | 1 |
| de la Iglesia, FA | 1 |
| Kirkegaard, P | 1 |
| Peraino, C | 1 |
| Fry, RJ | 1 |
| Staffeldt, E | 1 |
| Christopher, JP | 1 |
| Bock, KW | 1 |
| Bock-Hennig, BS | 1 |
| Maeda, T | 1 |
| Sano, N | 1 |
| Togei, K | 1 |
| Shibata, M | 1 |
| Izumi, K | 1 |
| Otsuka, H | 1 |
| Maislos, M | 1 |
| Sobel, R | 1 |
| Shany, S | 1 |
11 other studies available for phenytoin and Liver Neoplasms
| Article | Year |
|---|---|
HepaRG cell line as an in vitro model for screening drug-drug interactions mediated by metabolic induction: amiodarone used as a model substance.
Topics: Amiodarone; Carcinoma, Hepatocellular; Cell Line, Tumor; Cytochrome P-450 Enzyme System; Drug Intera | 2014 |
Association between antiepileptic drugs and hepatocellular carcinoma in patients with epilepsy: a population-based case-control study.
Topics: Adult; Aged; Anticonvulsants; Carcinoma, Hepatocellular; Case-Control Studies; Epilepsy; Humans; Liv | 2016 |
A simultaneous assessment of CYP3A4 metabolism and induction in the DPX-2 cell line.
Topics: Carcinoma, Hepatocellular; Cell Line, Tumor; Chromans; Clotrimazole; Cytochrome P-450 CYP1A2; Cytoch | 2005 |
Antiepileptic treatment and risk for hepatobiliary cancer and malignant lymphoma.
Topics: Aged; Aged, 80 and over; Biliary Tract Neoplasms; Case-Control Studies; Epilepsy; Female; Humans; Li | 1995 |
Tumor promotion by an anticonvulsant agent, phenytoin, in mouse liver: correlation with CYP2B induction.
Topics: Adenoma; Animals; Body Weight; Carcinogens; Cytochrome P-450 CYP2B1; Cytochrome P-450 Enzyme System; | 1993 |
Perspective on the carcinogenic potential of phenytoin based on rodent tumor bioassays and human epidemiological data.
Topics: Animals; Anticonvulsants; Carcinogenicity Tests; Dose-Response Relationship, Drug; Female; Humans; L | 1996 |
[Hepatocellular adenoma].
Topics: Abdomen; Adult; Carcinoma, Hepatocellular; Epilepsy; Hemorrhage; Humans; Liver Neoplasms; Male; Phen | 1976 |
Comparative enhancing effects of phenobarbital, amobarbital, diphenylhydantoin, and dichlorodiphenyltrichloroethane on 2-acetylaminofluorene-induced hepatic tumorigenesis in the rat.
Topics: 2-Acetylaminofluorene; Amobarbital; Animals; DDT; DNA, Neoplasm; Drug Synergism; Liver; Liver Neopla | 1975 |
Differential induction of human liver UDP-glucuronosyltransferase activities by phenobarbital-type inducers.
Topics: Acetaminophen; Adolescent; Adult; Benzopyrenes; Bilirubin; Carcinoma, Hepatocellular; Enzyme Inducti | 1987 |
Lack of carcinogenicity of phenytoin in (C57BL/6 x C3H)F1 mice.
Topics: Administration, Oral; Animals; Body Weight; Carcinogens; Female; Liver Neoplasms; Male; Mice; Phenyt | 1988 |
Leiomyoblastoma associated with intractable hypercalcemia and elevated 1,25-dihydroxycholecalciferol levels. Treatment by hepatic enzyme induction.
Topics: Adult; Calcitriol; Enzyme Induction; Female; Humans; Hypercalcemia; Leiomyoma; Liver; Liver Neoplasm | 1985 |