phenytoin has been researched along with Liver Diseases in 56 studies
Liver Diseases: Pathological processes of the LIVER.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A female neonate, whose mother had been treated throughout pregnancy with valproic acid and phenytoin, showed evident signs of liver damage, confirmed by laboratory investigations and biopsy." | 3.67 | Congenital liver damage after treatment of mother with valproic acid and phenytoin? ( Felding, I; Rane, A, 1984) |
| "Phenytoin is a highly effective anticonvulsant medication that is considered to be the treatment of choice for generalized major motor and focal epileptic seizures." | 3.66 | Phenytoin: pharmacokinetics and clinical therapeutics. ( Finn, AL; Olanow, CW, 1981) |
| " The severity of this adverse effect ranges from self-limiting to fatal." | 2.38 | Phenytoin hepatotoxicity: a review of the literature. ( Smythe, MA; Umstead, GS, 1989) |
| " Commonly used drugs are discussed and the effects of disease, drug dosage and hypoalbuminaemia on drug-protein binding are reviewed." | 2.36 | Protein binding of drugs--the clinical significance. ( Buchanan, N, 1978) |
| "Anticonvulsant therapy was among the first areas to benefit from clinical pharmacokinetic studies." | 2.35 | Clinical pharmacokinetics of anticonvulsants. ( Dam, M; Hvidberg, EF, 1976) |
| " A loading dose of intravenous phenytoin 2700 mg was administered, followed by maintenance dosing of intravenous phenytoin 150 mg every 8 hours." | 1.39 | Phenytoin removal by continuous venovenous hemofiltration. ( Herrmann, DJ; Oltrogge, KM; Peppard, WJ; Regner, KR; Saleh, M, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 46 (82.14) | 18.7374 |
| 1990's | 5 (8.93) | 18.2507 |
| 2000's | 4 (7.14) | 29.6817 |
| 2010's | 1 (1.79) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Oltrogge, KM | 1 |
| Peppard, WJ | 1 |
| Saleh, M | 1 |
| Regner, KR | 1 |
| Herrmann, DJ | 1 |
| CRAWFORD, SE | 1 |
| JONES, CK | 1 |
| YANOFF, M | 1 |
| RAWSON, AJ | 1 |
| HOLLAND, P | 1 |
| MAUER, AM | 1 |
| KUTT, H | 2 |
| WINTERS, W | 1 |
| SCHERMAN, R | 1 |
| MCDOWELL, F | 1 |
| MARCHAND, L | 1 |
| TEULIE, G | 1 |
| BALIER, C | 1 |
| DUBOIS, EL | 1 |
| Jinjuvadia, K | 1 |
| Kwan, W | 1 |
| Fontana, RJ | 1 |
| Delima, SI | 1 |
| Walsh, LE | 1 |
| Golomb, MR | 1 |
| Bukowskyj, M | 1 |
| Nakatsu, K | 1 |
| Munt, PW | 1 |
| DeSwarte, RD | 1 |
| Hövels, O | 1 |
| Bruni, J | 1 |
| Albright, PS | 1 |
| Felding, I | 1 |
| Rane, A | 1 |
| Asconapé, JJ | 1 |
| Penry, JK | 1 |
| Perucca, E | 1 |
| Olanow, CW | 1 |
| Finn, AL | 1 |
| Epping, J | 1 |
| Fuchshofen, M | 1 |
| Richter, E | 1 |
| Mullick, FG | 1 |
| Ishak, KG | 1 |
| Sugimoto, T | 1 |
| Muro, H | 1 |
| Woo, M | 1 |
| Nishida, N | 1 |
| Murakami, K | 1 |
| Strom, SC | 1 |
| Fisher, RA | 1 |
| Rubinstein, WS | 1 |
| Barranger, JA | 1 |
| Towbin, RB | 1 |
| Charron, M | 1 |
| Mieles, L | 1 |
| Pisarov, LA | 1 |
| Dorko, K | 1 |
| Thompson, MT | 1 |
| Reyes, J | 1 |
| Dasgupta, A | 1 |
| Schlette, E | 1 |
| Rumack, BH | 1 |
| Kaspar, U | 1 |
| Ziegler, HK | 1 |
| Sinazadeh, M | 1 |
| Buchanan, N | 1 |
| Henry, DA | 1 |
| Sharpe, G | 1 |
| Chaplain, S | 1 |
| Cartwright, S | 1 |
| Kitchingman, G | 1 |
| Bell, GD | 1 |
| Langman, MJ | 1 |
| Parker, WA | 1 |
| Shearer, CA | 1 |
| Hvidberg, EF | 1 |
| Dam, M | 1 |
| Cammann, R | 1 |
| Wiechert, P | 1 |
| Remmer, H | 1 |
| Olsen, GD | 1 |
| Bennett, WM | 1 |
| Porter, GA | 1 |
| Affrime, M | 1 |
| Reidenberg, MM | 1 |
| Foster, GR | 1 |
| Goldin, RD | 1 |
| Freeth, CJ | 1 |
| Nieman, E | 1 |
| Oliveira, DB | 1 |
| Weidle, PJ | 1 |
| Skiest, DJ | 1 |
| Forrest, A | 1 |
| Gomita, Y | 1 |
| Furuno, K | 1 |
| Araki, Y | 1 |
| Smythe, MA | 1 |
| Umstead, GS | 1 |
| Lisker-Melman, M | 1 |
| Hoofnagle, JH | 1 |
| Himelman, RB | 1 |
| Olsson, R | 1 |
| Zettergren, L | 1 |
| Bunch, SE | 1 |
| Conway, MB | 1 |
| Center, SA | 1 |
| Castleman, WL | 1 |
| Baldwin, BH | 1 |
| Hornbuckle, WE | 1 |
| Tennant, BC | 1 |
| Miyai, K | 1 |
| Ito, K | 1 |
| Dhar, GJ | 1 |
| Pierach, CA | 1 |
| Ahamed, PN | 1 |
| Howard, RB | 1 |
| Martin, W | 1 |
| Rickers, J | 1 |
| Whitfield, JB | 1 |
| Pounder, RE | 1 |
| Neale, G | 1 |
| Moss, DW | 1 |
| Doherty, JE | 1 |
| Atkinson, AJ | 1 |
| Kessler, KM | 1 |
| Levy, RH | 1 |
| Smith, GH | 1 |
| Bochner, F | 2 |
| Hooper, W | 1 |
| Tyrer, J | 1 |
| Eadie, M | 1 |
| Eadie, MJ | 2 |
| Tyrer, JH | 2 |
| Hooper, WD | 2 |
| Andreasen, PB | 1 |
| Hansen, JM | 1 |
| Skovsted, L | 1 |
| Siersbaek-Nielsen, K | 1 |
14 reviews available for phenytoin and Liver Diseases
| Article | Year |
|---|---|
Theophylline reassessed.
Topics: Acidosis; Aging; Allopurinol; Animals; Anti-Bacterial Agents; Breast Feeding; Bronchodilator Agents; | 1984 |
[Clinical course and pathogenesis or rachitis].
Topics: Age Factors; Barbiturates; Breast Feeding; Calcifediol; Calcium; Child; Humans; Infant, Newborn; Inf | 1983 |
The clinical pharmacology of antiepileptic drugs.
Topics: Adult; Anticonvulsants; Benzodiazepines; Carbamazepine; Drug Interactions; Ethosuximide; Female; Hal | 1984 |
Use of antiepileptic drugs in the presence of liver and kidney diseases: a review.
Topics: Anticonvulsants; Carbamazepine; Epilepsy; Half-Life; Humans; Kidney Diseases; Kinetics; Liver Diseas | 1982 |
Plasma protein binding of phenytoin in health and disease: relevance to therapeutic drug monitoring.
Topics: Aging; Bilirubin; Blood Proteins; Burns; Disease; Drug Interactions; Fatty Acids, Nonesterified; Hum | 1980 |
[Diphenylhydantoin. Metabolism, pharmacokinetics, interactions and side effects].
Topics: Anti-Anxiety Agents; Benzodiazepines; Bone and Bones; Bone Marrow; Carbamazepine; Cerebellar Disease | 1976 |
Protein binding of drugs--the clinical significance.
Topics: Adrenal Cortex Hormones; Anti-Bacterial Agents; Anticoagulants; Humans; Imipramine; Kidney; Kidney D | 1978 |
Clinical pharmacokinetics of anticonvulsants.
Topics: Administration, Oral; Adult; Aged; Aging; Animals; Anticonvulsants; Carbamazepine; Child; Clonazepam | 1976 |
Phenytoin hepatotoxicity: a review of the literature.
Topics: Chemical and Drug Induced Liver Injury; Humans; Liver Diseases; Lymphocyte Activation; Phenytoin | 1989 |
Biochemical and genetic factors regulating dilantin metabolism in man.
Topics: Aminosalicylic Acids; Animals; Ataxia; Cats; Chlordan; Cycloserine; DDT; Dicumarol; Disulfiram; Enzy | 1971 |
[Thyroid hormone-binding protein and abnormalities of its function].
Topics: Estrogens; Female; Heart Diseases; Humans; Immunoelectrophoresis; Liver Diseases; Nephrosis; Phenyto | 1968 |
Digitalis glycosides. Pharmacokinetics and their clinical implications.
Topics: Acute Kidney Injury; Administration, Oral; Arrhythmias, Cardiac; Digitoxin; Digoxin; Drug Interactio | 1973 |
Individualization of anticonvulsant therapy.
Topics: Adolescent; Adult; Animals; Anticonvulsants; Body Weight; Dose-Response Relationship, Drug; Drug Int | 1974 |
Individualization of dosage of antiarrhythmic drugs.
Topics: Dose-Response Relationship, Drug; Drug Interactions; Electrocardiography; Heart Diseases; Humans; Ki | 1974 |
42 other studies available for phenytoin and Liver Diseases
| Article | Year |
|---|---|
Phenytoin removal by continuous venovenous hemofiltration.
Topics: Acute Kidney Injury; Anticonvulsants; Critical Illness; Female; Hemofiltration; Humans; Liver Diseas | 2013 |
Fatal liver necrosis and diphenylhydantoin sensitivity.
Topics: Drug Hypersensitivity; Epilepsy; Epilepsy, Tonic-Clonic; Humans; Liver Diseases; Phenytoin; Seizures | 1962 |
PELIOSIS HEPATIS. AN ANATOMIC STUDY WITH DEMONSTRATION OF TWO VARIETIES.
Topics: Anatomy; Chlorambucil; Classification; Cyclophosphamide; Dactinomycin; Femoral Fractures; Geriatrics | 1964 |
DRUG-INDUCED IN-VITRO STIMULATION OF PERIPHERAL LYMPHOCYTES.
Topics: Antigen-Antibody Reactions; Child; Dermatitis; Drug Hypersensitivity; Epilepsy; Fever; Hepatomegaly; | 1964 |
DIPHENYLHYDANTOIN AND PHENOBARBITAL TOXICITY. THE ROLE OF LIVER DISEASE.
Topics: Ataxia; Barbiturates; Blood Chemical Analysis; Chromatography; Drug Tolerance; Hepatitis; Hepatitis | 1964 |
[Leukemia in an epileptic treated with gardenal and dihydan; recovery; fatal mysoline poisoning with fatty degeneration of the liver and acute epithelial nephritis].
Topics: Anticonvulsants; Barbiturates; Epilepsy; Humans; Hydantoins; Leukemia; Leukocytosis; Liver Diseases; | 1955 |
Toxic hepatic necrosis associated with taking dilantin, tridione and phenobarbital; report of a case.
Topics: Aged; Barbital; Hepatitis; Humans; Hydantoins; Liver; Liver Diseases; Phenobarbital; Phenytoin; Trim | 1950 |
Searching for a needle in a haystack: use of ICD-9-CM codes in drug-induced liver injury.
Topics: Adolescent; Adult; Aged; Amoxicillin-Potassium Clavulanate Combination; Chemical and Drug Induced Li | 2007 |
Simultaneous toxicities in a child on multiple anticonvulsants.
Topics: Anticonvulsants; Bone Marrow; Bone Marrow Diseases; Chemical and Drug Induced Liver Injury; Child, P | 2008 |
Drug allergy--problems and strategies.
Topics: Anaphylaxis; Anemia, Hemolytic; Antigen-Antibody Complex; Desensitization, Immunologic; Dose-Respons | 1984 |
Congenital liver damage after treatment of mother with valproic acid and phenytoin?
Topics: Adult; Epilepsy, Tonic-Clonic; Female; Humans; Infant; Liver; Liver Diseases; Maternal-Fetal Exchang | 1984 |
Phenytoin: pharmacokinetics and clinical therapeutics.
Topics: Abnormalities, Drug-Induced; Biological Availability; Drug Interactions; Humans; Kidney Diseases; Li | 1981 |
[Enterohepatic circulation in liver diseases].
Topics: Animals; Barbiturates; Bile Acids and Salts; Biotransformation; Bisacodyl; Chloramphenicol; Cholesta | 1980 |
Hepatic injury associated with diphenylhydantoin therapy. A clinicopathologic study of 20 cases.
Topics: Adult; Aged; Chemical and Drug Induced Liver Injury; Female; Humans; Liver; Liver Diseases; Male; Mi | 1980 |
Valproate metabolites in high-dose valproate plus phenytoin therapy.
Topics: Adolescent; Alanine Transaminase; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injur | 1996 |
Transplantation of human hepatocytes.
Topics: Adolescent; Adult; Cell Culture Techniques; Cell Transplantation; Child, Preschool; Female; Hepatic | 1997 |
Rapid in vitro conversion of fosphenytoin into phenytoin in sera of patients with liver disease: role of alkaline phosphatase.
Topics: Alkaline Phosphatase; Anticonvulsants; Fluorescence Polarization Immunoassay; Humans; Liver Diseases | 2001 |
Acetaminophen hepatotoxicity: the first 35 years.
Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Analgesics, Non-Narcotic; Anticonvulsants; Aspa | 2002 |
[Anticonvulsant drugs and liver damage (Author's transl)].
Topics: Adult; Anticonvulsants; Antitubercular Agents; Autopsy; Chemical and Drug Induced Liver Injury; Chol | 1975 |
The [14C]-aminopyrine breath test. A comparison of different forms of analysis.
Topics: Aminopyrine; Breath Tests; Carbon Dioxide; Epilepsy; Glucaric Acid; Glutethimide; Humans; Liver Dise | 1979 |
Phenytoin hepatotoxicity: a case report and review.
Topics: Adolescent; Adult; Aged; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Female; Hu | 1979 |
Clinicopathological Conference. Diagnostic difficulties in a case of polypharmacy. Demonstrated at the Royal College of Physicians of London.
Topics: Acute Kidney Injury; Chemical and Drug Induced Liver Injury; Diagnosis, Differential; Hepatitis, Vir | 1977 |
[Liver damage after long-term administration of phenylethylbarbituric acid and diphenylhydantoin].
Topics: Adolescent; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Epilepsy; Humans; Leucy | 1977 |
[Biotransformation and its modification by barbiturates].
Topics: Binding Sites; Biotransformation; Drug Interactions; Enzyme Induction; Epilepsy; Humans; Liver; Live | 1977 |
Morphine and phenytoin binding to plasma proteins in renal and hepatic failure.
Topics: Bilirubin; Blood Proteins; Creatinine; Humans; Jaundice; Kidney Failure, Chronic; Kidney Transplanta | 1975 |
The protein binding of some drugs in plasma from patients with alcoholic liver disease.
Topics: Alcoholism; Blood Proteins; Chronic Disease; Dapsone; Fluoresceins; Humans; Liver Diseases; Pharmace | 1975 |
Liver damage in long-term anticonvulsant therapy: a serological and histological study.
Topics: Adult; Aged; Anticonvulsants; Carbamazepine; Chemical and Drug Induced Liver Injury; Drug Combinatio | 1991 |
Multiple-dose activate charcoal as adjunct therapy after chronic phenytoin intoxication.
Topics: Aged; Charcoal; Female; Humans; Liver Cirrhosis, Alcoholic; Liver Diseases; Phenytoin; Poisoning | 1991 |
[Therapeutic drug monitoring of phenytoin].
Topics: Adolescent; Adult; Age Factors; Biological Availability; Child; Child, Preschool; Dosage Forms; Drug | 1990 |
Phenytoin hepatotoxicity masked by corticosteroids.
Topics: Brain Edema; Chemical and Drug Induced Liver Injury; Dexamethasone; Drug Hypersensitivity; Humans; L | 1989 |
Fulminant hepatic failure six weeks postpartum.
Topics: Adult; Ascites; Chemical and Drug Induced Liver Injury; Female; Humans; Liver Diseases; Phenytoin; P | 1986 |
Anticonvulsant-induced liver damage.
Topics: Adult; Anticonvulsants; Carbamazepine; Chemical and Drug Induced Liver Injury; Clonazepam; Humans; L | 1988 |
Toxic hepatopathy and intrahepatic cholestasis associated with phenytoin administration in combination with other anticonvulsant drugs in three dogs.
Topics: Animals; Anticonvulsants; Chemical and Drug Induced Liver Injury; Cholestasis, Intrahepatic; Dog Dis | 1987 |
Editorial: Drug metabolism in disease.
Topics: Alanine Transaminase; Anti-Bacterial Agents; Antipyrine; Half-Life; Humans; Kidney; Kidney Diseases; | 1974 |
Diphenylhydantoin--induced hepatic necrosis.
Topics: Adult; Chemical and Drug Induced Liver Injury; Drug Hypersensitivity; Epilepsy, Tonic-Clonic; Female | 1974 |
[Cholestatic hepatosis induced by diphenylhydantoin].
Topics: Adult; Chemical and Drug Induced Liver Injury; Cholestasis; Diagnosis, Differential; Drug Eruptions; | 1972 |
Serum -glytamyl transpeptidase activity in liver disease.
Topics: Acyltransferases; Adolescent; Adult; Aged; Alkaline Phosphatase; Aspartate Aminotransferases; Barbit | 1972 |
Dosage regimens of antiarrhythmics. II. Applications.
Topics: Anti-Arrhythmia Agents; Heart Failure; Humans; Injections, Intravenous; Kidney Diseases; Lidocaine; | 1973 |
Clinical implications of certain aspects of diphenylhydantoin metabolism.
Topics: Enzyme Induction; Humans; Hydantoins; Kidney; Liver; Liver Diseases; Male; Phenytoin; Protein Bindin | 1973 |
Diphenylhydantoin dosage.
Topics: Adolescent; Adult; Age Factors; Body Weight; Child; Chromatography, Gas; Drug Interactions; Epilepsy | 1973 |
Plasma protein binding of diphenylhydantoin. Effects of sex hormones, renal and hepatic disease.
Topics: Adult; Age Factors; Aged; Bilirubin; Blood Proteins; Contraceptives, Oral; Female; Gonadal Steroid H | 1974 |
Folic acid and the half-life of diphenylhydantoin in man.
Topics: Carbon Isotopes; Female; Folic Acid; Folic Acid Deficiency; Half-Life; Humans; Kidney Diseases; Live | 1971 |