phenytoin has been researched along with Liver Cirrhosis in 17 studies
Liver Cirrhosis: Liver disease in which the normal microcirculation, the gross vascular anatomy, and the hepatic architecture have been variably destroyed and altered with fibrous septa surrounding regenerated or regenerating parenchymal nodules.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In an exploratory study the 24-h urinary excretion pattern of caffeine and 14 of its major metabolites was studied in 32 volunteers (adults, adolescents and children), 14 patients either with end stage renal disease or liver cirrhosis, 7 heavy smokers and 27 patients on therapy with cimetidine, allopurinol, theophylline or phenytoin." | 3.68 | Urinary caffeine metabolites in man. Age-dependent changes and pattern in various clinical situations. ( Bircher, J; Brandes, A; Compagnone, D; Hille, H; Münch, B; Ullrich, D, 1992) |
| "After treatment with valproic acid a 19-year-old female patient with Friedreich's ataxia and generalised epilepsy died following acute hepatic failure with massive lactacidosis." | 3.67 | [Acute liver necrosis caused by valproate]. ( Hackenberg, K; Rengeling, M; Rühl, G; Zäh, W, 1985) |
| "The pharmacokinetic behavior of fosphenytoin (FOS), the water-soluble prodrug of phenytoin (PHT), has been characterized in normal subjects." | 2.69 | Pharmacokinetics of fosphenytoin in patients with hepatic or renal disease. ( Alldredge, BK; Aweeka, FT; Boyer, TD; Eldon, MA; Gambertoglio, JG; Gottwald, MD; Kugler, AR; Pollock, AS; Wright, TL, 1999) |
| "The status epilepticus was resolved after antiepileptic therapy (phenytoin sodium) and treatment for hepatic encephalopathy (Branched chain amino acids)." | 1.33 | Hepatic encephalopathy with status epileptics: a case report. ( Hamagami, H; Ichinose, M; Kida, Y; Tanaka, H; Tsuji, T; Ueda, H, 2006) |
| " The dosage of anticonvulsant drug was found to modify certain test results." | 1.27 | Compromised hepatic function in dogs treated with anticonvulsant drugs. ( Baldwin, BH; Bunch, SE; Hornbuckle, WE; Tennant, BC, 1984) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 12 (70.59) | 18.7374 |
| 1990's | 3 (17.65) | 18.2507 |
| 2000's | 1 (5.88) | 29.6817 |
| 2010's | 1 (5.88) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lang, LM | 1 |
| Linnet, K | 1 |
| KUTT, H | 1 |
| WINTERS, W | 1 |
| SCHERMAN, R | 1 |
| MCDOWELL, F | 1 |
| Tanaka, H | 1 |
| Ueda, H | 1 |
| Kida, Y | 1 |
| Hamagami, H | 1 |
| Tsuji, T | 1 |
| Ichinose, M | 1 |
| Sotaniemi, EA | 1 |
| Pelkonen, RO | 1 |
| Puukka, M | 1 |
| Bunch, SE | 2 |
| Baldwin, BH | 1 |
| Hornbuckle, WE | 2 |
| Tennant, BC | 2 |
| Castleman, WL | 1 |
| Epping, J | 1 |
| Fuchshofen, M | 1 |
| Richter, E | 1 |
| Bissoli, F | 1 |
| Gini, G | 1 |
| Bosio, M | 1 |
| Ceriani, R | 1 |
| Aweeka, FT | 1 |
| Gottwald, MD | 1 |
| Gambertoglio, JG | 1 |
| Wright, TL | 1 |
| Boyer, TD | 1 |
| Pollock, AS | 1 |
| Eldon, MA | 1 |
| Kugler, AR | 1 |
| Alldredge, BK | 1 |
| Ziegler, HK | 1 |
| Sinazadeh, M | 1 |
| Jusko, WJ | 1 |
| Gretch, M | 1 |
| Ullrich, D | 1 |
| Compagnone, D | 1 |
| Münch, B | 1 |
| Brandes, A | 1 |
| Hille, H | 1 |
| Bircher, J | 1 |
| Zäh, W | 1 |
| Rengeling, M | 1 |
| Rühl, G | 1 |
| Hackenberg, K | 1 |
| Reidenberg, MM | 2 |
| Affrime, M | 1 |
| Kurata, D | 1 |
| Wilkinson, GR | 1 |
| Zaninovich, AA | 1 |
| Farach, H | 1 |
| Ezrin, C | 1 |
| Volpé, R | 1 |
2 reviews available for phenytoin and Liver Cirrhosis
| Article | Year |
|---|---|
Plasma and tissue protein binding of drugs in pharmacokinetics.
Topics: Adrenal Cortex Hormones; Age Factors; Aging; Albumins; Animals; Anti-Bacterial Agents; Antibodies; A | 1976 |
Effect of disease states on plasma protein binding of drugs.
Topics: Blood Proteins; Blood Urea Nitrogen; Creatinine; Dapsone; Digitoxin; Drug Interactions; Humans; Hypo | 1974 |
1 trial available for phenytoin and Liver Cirrhosis
| Article | Year |
|---|---|
Pharmacokinetics of fosphenytoin in patients with hepatic or renal disease.
Topics: Adult; Anticonvulsants; Chromatography, High Pressure Liquid; Humans; Infusions, Intravenous; Kidney | 1999 |
14 other studies available for phenytoin and Liver Cirrhosis
| Article | Year |
|---|---|
The ratio of 6β-hydroxycortisol to cortisol in urine as a measure of cytochrome P450 3A activity in postmortem cases.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Biomarkers; Carbamazepine; Child; Cytochrome P-450 CYP3A | 2014 |
DIPHENYLHYDANTOIN AND PHENOBARBITAL TOXICITY. THE ROLE OF LIVER DISEASE.
Topics: Ataxia; Barbiturates; Blood Chemical Analysis; Chromatography; Drug Tolerance; Hepatitis; Hepatitis | 1964 |
Hepatic encephalopathy with status epileptics: a case report.
Topics: Amino Acids, Branched-Chain; Ammonia; Brain; Electroencephalography; Hepatic Encephalopathy; Humans; | 2006 |
Measurement of hepatic drug-metabolizing enxyme activity in man. Comparison of three different assays.
Topics: Adult; Aged; Antipyrine; Cytochrome P-450 Enzyme System; Enzyme Induction; Female; Glucaric Acid; He | 1980 |
Compromised hepatic function in dogs treated with anticonvulsant drugs.
Topics: Animals; Anticonvulsants; Dog Diseases; Dogs; Dose-Response Relationship, Drug; Drug Therapy, Combin | 1984 |
Hepatic cirrhosis associated with long-term anticonvulsant drug therapy in dogs.
Topics: Animals; Anticonvulsants; Dog Diseases; Dogs; Female; Liver; Liver Cirrhosis; Male; Microscopy, Elec | 1982 |
[Enterohepatic circulation in liver diseases].
Topics: Animals; Barbiturates; Bile Acids and Salts; Biotransformation; Bisacodyl; Chloramphenicol; Cholesta | 1980 |
Concurrent use of phenytoin and furosemide: problems in a patient with congestive cardiac failure, chronic renal failure, liver cirrhosis and fluid overload.
Topics: Anticonvulsants; Diuretics; Drug Interactions; Drug Therapy, Combination; Furosemide; Heart Failure; | 1996 |
[Anticonvulsant drugs and liver damage (Author's transl)].
Topics: Adult; Anticonvulsants; Antitubercular Agents; Autopsy; Chemical and Drug Induced Liver Injury; Chol | 1975 |
Urinary caffeine metabolites in man. Age-dependent changes and pattern in various clinical situations.
Topics: Adolescent; Adult; Age Factors; Allopurinol; Caffeine; Child; Cimetidine; Drug Interactions; Female; | 1992 |
[Acute liver necrosis caused by valproate].
Topics: Adult; Creatine Kinase; Epilepsy; Female; Humans; Liver Cirrhosis; Phenytoin; Transaminases; Valproi | 1985 |
Influence of disease on binding of drugs to plasma proteins.
Topics: Arrhythmias, Cardiac; Arteriosclerosis; Blood Proteins; Blood Urea Nitrogen; Carbon Radioisotopes; C | 1973 |
Erythrocyte uptake and plasma binding of diphenylhydantoin.
Topics: Carbon Radioisotopes; Dialysis; Erythrocytes; Ethosuximide; Female; Hematocrit; Humans; Hydroxylatio | 1974 |
Lack of significant binding of L-triiodothyronine by thyroxine-binding globulin in vivo as demonstrated by acute disappearance of 131-I-labeled triiodothyronine.
Topics: Adolescent; Adult; Aged; Epilepsy; Estrogens; Female; Hepatitis; Humans; Hyperthyroidism; Hypothyroi | 1966 |