Compounds > phenytoin
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phenytoin and Libman-Sacks Disease

phenytoin has been researched along with Libman-Sacks Disease in 49 studies

Research Excerpts

ExcerptRelevanceReference
"Myocarditis and pericarditis are identified at autopsy in up to 50% of patients with systemic lupus erythematosus."5.35Fulminant myopericarditis from phenytoin-induced systemic lupus erythematosus. ( Ai, Z; Atwater, BD; Wolff, MR, 2008)
" Following treatment with antiepileptic drugs (AEDs), the patient developed several rare complications: after beginning therapy with phenytoin, the patient developed pseudolymphoma; after monotherapy with carbamazepine (CBZ), the patient thereafter developed myoclonic jerks of upper and lower limbs upon awakening; after one year of treatment with valproate (VPA) the patient developed clinical and immuno-haematological signs of SLE."3.69Clinical case report: multiple idiosyncratic adverse effects of antiepileptic drugs in trisomy 9p. ( Diomedi, M; Gigli, GL; Masala, C; Placidi, F; Pomponi, MG; Scalise, A; Silvestri, G, 1996)
"Myocarditis and pericarditis are identified at autopsy in up to 50% of patients with systemic lupus erythematosus."1.35Fulminant myopericarditis from phenytoin-induced systemic lupus erythematosus. ( Ai, Z; Atwater, BD; Wolff, MR, 2008)
"Aplastic anemia is rare in SLE and the response to immunosuppressants is variable, but here is a success story."1.32Aplastic anemia complicating systemic lupus erythematosus: successful management with cyclosporine. ( Agarwal, SK; Garg, D; Kubba, S; Makhija, A; Pathania, A; Prakash, A; Prakash, N; Singh, NP, 2004)
"Though there are analogies to the systemic lupus erythematosus, we must take into consideration a diversity of diseases."1.27[Drug-induced lupus erythematosus syndrome. Pathogenesis and relation to systemic lupus erythematosus]. ( Wollina, U, 1984)
"Drug-induced systemic lupus erythematosus (SLE)-like syndromes in children are most commonly associated with the administration of ethosuximide, diphenylhydantoin, and trimethadione."1.26Antinuclear antibodies and lupus-like syndromes in children receiving anticonvulsants. ( Fishman, L; Hanson, V; Singsen, BH, 1976)
"Features of both systemic lupus erythematosus and scleroderma developed in a young Chinese girl while on multiple anticonvulsant therapy."1.25Lupus-scleroderma syndrome induced by ethosuximide. ( Chan, HL; Teoh, PC, 1975)

Research

Studies (49)

TimeframeStudies, this research(%)All Research%
pre-199041 (83.67)18.7374
1990's2 (4.08)18.2507
2000's5 (10.20)29.6817
2010's1 (2.04)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Atwater, BD1
Ai, Z1
Wolff, MR1
Geara, AS1
Torbey, E1
El-imad, B1
Defelice, T1
Lu, P1
Loyd, A1
Patel, R1
Franks, AG1
Singh, NP1
Prakash, A1
Garg, D1
Makhija, A1
Pathania, A1
Prakash, N1
Kubba, S1
Agarwal, SK1
RAMON, Y1
ZIPRKOWSKI, L1
GOLDRING, D1
LEVINE, MC1
FULTON, WH1
DYKEN, PR1
BERLINGHOFF, W1
SOENNICHSEN, N1
HOLLEY, HL1
WILSKE, KR1
SHALIT, IE1
WILLKENS, RF1
DECKER, JL1
Tristano, AG1
Falcón, L1
Willson, M1
de Oca, IM1
Lin, SC1
Shyur, SD1
Wu, JY1
Ma, YC1
Siegel, M1
Lee, SL1
Peress, NS1
DeSwarte, RD1
Amadori, G1
Fiore, D1
Furst, DE1
Alarcón-Segovia, D1
Palacios, R1
Wollina, U1
Gleichman, H1
Gigli, GL1
Scalise, A1
Silvestri, G1
Diomedi, M1
Placidi, F1
Pomponi, MG1
Masala, C1
Wutke, K1
Müller, E1
Dittrich, P1
Gleichmann, E1
van Elven, F1
Gleichmann, H1
Zangemeister, WH1
Weisner, B1
Ooi, BS1
Kant, KS1
Hanenson, IB1
Pesce, AJ1
Pollak, VE1
Wallace, EZ1
Rosman, PM1
Balthazar, A1
Sacerdote, A1
Teoh, PC1
Chan, HL1
Rybicka, K1
Wierzchowiecki, M1
Boylan, JJ1
Owen, DS1
Chin, JB1
Singsen, BH1
Fishman, L1
Hanson, V1
Dreyling, KW1
Wanner, C1
Schollmeyer, P1
Jiang, M1
Maeda, M1
Kitamura, Y1
Takata, M1
Nakamura, Y1
Masuda, S1
Nishida, K1
Hata, F1
Okada, K1
Chinzei, T1
Yamashiro, K1
Brown-Molnar, CS1
Bauer, LA1
Horn, JR1
Epstein, A1
Barland, P1
Lovisetto, P1
Mairano, D1
Cargnino, M1
Biarese, V1
Marchi, L1
Lerda, R1
Burge, SM1
Dawber, RP1
Golochevskaia, VS1
Sidiq, M1
Kirsner, AB1
Sheon, RP1
Thoenes, W1
Thoenes, G1
Ansorge, R1
Dorfman, RF1
Warnke, R1
Harpey, JP1
Eldredge, NT1
van Robertson, WB1
Jiller, JJ1
Cohen, SN1
Weber, WW1
Galea, G1
Geavlete, A1
Kobayashi, I1
Yamashita, Y1
Yamazaki H OKUDA, S1
Andreasen, PB1
Heshe, J1
Okuda, M1
Furusawa, S1
Sakurai, T1
Shishido, H1
Ortiz-Neu, C1
LeRoy, EC1
Ahuja, GK1
Schumacher, GA1

Reviews

4 reviews available for phenytoin and Libman-Sacks Disease

ArticleYear
[Side effects of anti-arrhythmic agents].
    Klinicheskaia meditsina, 1971, Volume: 49, Issue:10

    Topics: 1-Propanol; Adrenal Cortex Hormones; Agranulocytosis; Anorexia Nervosa; Anti-Arrhythmia Agents; Anti

1971
Lymphadenopathy simulating the malignant lymphomas.
    Human pathology, 1974, Volume: 5, Issue:5

    Topics: Animals; Biopsy; Dermatitis; Drug Hypersensitivity; Herpes Zoster; Humans; Hyalin; Hyperplasia; Infe

1974
Lupus-like syndromes induced by drugs.
    Annals of allergy, 1974, Volume: 33, Issue:5

    Topics: Antibodies, Antinuclear; Antibody Formation; Arthritis, Rheumatoid; Chlorpromazine; DNA, Single-Stra

1974
Pharmacogenetics.
    Pediatric clinics of North America, 1972, Volume: 19, Issue:1

    Topics: Analgesics; Anemia, Hemolytic; Anesthetics; Apnea; Bone Marrow Diseases; Child; Child, Preschool; Ch

1972

Other Studies

45 other studies available for phenytoin and Libman-Sacks Disease

ArticleYear
Fulminant myopericarditis from phenytoin-induced systemic lupus erythematosus.
    WMJ : official publication of the State Medical Society of Wisconsin, 2008, Volume: 107, Issue:6

    Topics: Contrast Media; Echocardiography; Humans; Lupus Erythematosus, Systemic; Magnetic Resonance Imaging;

2008
Lupus cerebritis after visiting a tanning salon.
    Bulletin of the NYU hospital for joint diseases, 2009, Volume: 67, Issue:4

    Topics: Antibodies, Antinuclear; Anticonvulsants; Beauty Culture; Female; Headache; Humans; Immunosuppressiv

2009
Livedo racemosa, secondary to drug-induced systemic lupus erythematosus.
    Dermatology online journal, 2010, Nov-15, Volume: 16, Issue:11

    Topics: Adult; Aspirin; Autoantibodies; Histones; Humans; Livedo Reticularis; Lupus Erythematosus, Systemic;

2010
Aplastic anemia complicating systemic lupus erythematosus: successful management with cyclosporine.
    Rheumatology international, 2004, Volume: 24, Issue:1

    Topics: Adult; Anemia, Aplastic; Cyclophosphamide; Cyclosporine; Female; Humans; Lupus Erythematosus, System

2004
Pyroninophilic bodies in the gingivae.
    American journal of clinical pathology, 1962, Volume: 38

    Topics: Coloring Agents; Gingiva; Humans; Lupus Erythematosus, Systemic; Phenytoin; Staining and Labeling

1962
LUPUS ERYTHEMATOSUS AND ANTICONVULSANT DRUGS.
    Pediatrics, 1964, Volume: 33

    Topics: Anticonvulsants; Diagnosis; Humans; Hypersensitivity; Lupus Erythematosus, Systemic; Phenytoin; Toxi

1964
NEUROLOGICAL SYNDROMES OF SYSTEMIC LUPUS ERYTHEMATOSUS.
    Neurology, 1964, Volume: 14

    Topics: Adolescent; Anticonvulsants; Autoimmune Diseases; Blood Proteins; Cerebral Cortex; Cerebrospinal Flu

1964
[DEMONSTRATION OF THE "TRANSFER FACTOR" IN HYDANTOIN ALLERGY PRESENTING AS SUBACUTE LUPUS ERYTHEMATOSUS IN GENUINE EPILEPSY].
    Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete, 1964, Volume: 15

    Topics: Anticonvulsants; Drug Eruptions; Drug Hypersensitivity; Epilepsy; Lupus Erythematosus, Systemic; Phe

1964
EVIDENCE FOR A PREDISPOSITION TO RHEUMATIC DISEASES IN FAMILIES OF PATIENTS DEVELOPING DRUG-INDUCED SYSTEMIC LUPUS ERYTHEMATOSUS.
    Arthritis and rheumatism, 1964, Volume: 7

    Topics: Adolescent; Anticonvulsants; Child; Disease Susceptibility; Drug Therapy; Genetics, Medical; Humans;

1964
FINDINGS SUGGESTIVE OF SYSTEMIC LUPUS ERYTHEMATOSUS IN SUBJECTS ON CHRONIC ANTICONVULSANT THERAPY.
    Arthritis and rheumatism, 1965, Volume: 8

    Topics: Anticonvulsants; Barbiturates; Drug Therapy; Intellectual Disability; Lupus Erythematosus, Systemic;

1965
Seizure associated with chloroquine therapy in a patient with systemic lupus erythematosus.
    Rheumatology international, 2004, Volume: 24, Issue:5

    Topics: Adolescent; Anticonvulsants; Antirheumatic Agents; Causality; Chloroquine; Female; Humans; Lupus Ery

2004
Focal seizures as an unusual presentation of neonatal lupus erythematosus.
    Asian Pacific journal of allergy and immunology, 2005, Volume: 23, Issue:1

    Topics: Anemia; Anticonvulsants; Autoantigens; Humans; Infant, Newborn; Lupus Erythematosus, Cutaneous; Lupu

2005
The epidemiology of drug-induced systemic lupus erythematosus.
    Arthritis and rheumatism, 1967, Volume: 10, Issue:5

    Topics: Adolescent; Adult; Aged; Child; Epilepsy; Female; Heart Diseases; Humans; Hydralazine; Hypertension;

1967
Drug allergy--problems and strategies.
    The Journal of allergy and clinical immunology, 1984, Volume: 74, Issue:3 Pt 1

    Topics: Anaphylaxis; Anemia, Hemolytic; Antigen-Antibody Complex; Desensitization, Immunologic; Dose-Respons

1984
[Diagnostic problems in hydantoin immunopathy. Review of the literature and description of 3 cases].
    Minerva medica, 1984, Nov-03, Volume: 75, Issue:42

    Topics: Adolescent; Adult; Female; Fluorescent Antibody Technique; Humans; Immunoblastic Lymphadenopathy; Ki

1984
Use of ibuprofen in unusual circumstances.
    The American journal of medicine, 1984, Jul-13, Volume: 77, Issue:1A

    Topics: Arthritis, Rheumatoid; Aspirin; Bartter Syndrome; Cyclooxygenase Inhibitors; Digoxin; Drug Hypersens

1984
Differences in immunoregulatory T cell circuits between diphenylhydantoin-related and spontaneously occurring systemic lupus erythematosus.
    Arthritis and rheumatism, 1981, Volume: 24, Issue:8

    Topics: Adolescent; Adult; Antibodies, Monoclonal; Feedback; Female; Humans; Lupus Erythematosus, Systemic;

1981
[Drug-induced lupus erythematosus syndrome. Pathogenesis and relation to systemic lupus erythematosus].
    Zeitschrift fur die gesamte innere Medizin und ihre Grenzgebiete, 1984, Mar-01, Volume: 39, Issue:5

    Topics: Diagnosis, Differential; Drug-Related Side Effects and Adverse Reactions; Humans; Hydralazine; Lupus

1984
Systemic lupus erythematous triggered by diphenylhydantoin.
    Arthritis and rheumatism, 1982, Volume: 25, Issue:11

    Topics: Animals; Humans; Lupus Erythematosus, Systemic; Lymphocytes; Mice; Phenytoin

1982
Clinical case report: multiple idiosyncratic adverse effects of antiepileptic drugs in trisomy 9p.
    The International journal of neuroscience, 1996, Volume: 87, Issue:3-4

    Topics: Adult; Anticonvulsants; Brain; Carbamazepine; Chromosome Aberrations; Chromosome Disorders; Chromoso

1996
[The coincidence of visceral lupus erythematosus and epilepsy].
    Zeitschrift fur die gesamte innere Medizin und ihre Grenzgebiete, 1978, Sep-15, Volume: 33, Issue:18

    Topics: Adolescent; Carbamazepine; Epilepsy, Tonic-Clonic; Humans; Lupus Erythematosus, Systemic; Male; Phen

1978
Immunoblastic lymphadenopathy, systemic lupus erythematosus, and related disorders. Possible pathogenetic pathways.
    American journal of clinical pathology, 1979, Volume: 72, Issue:4 Suppl

    Topics: Animals; Autoantibodies; B-Lymphocytes; Drug Hypersensitivity; Graft vs Host Reaction; Humans; Immun

1979
[A progressive systemic sclerosis like disease due to anticonvulsive therapy? (author's transl)].
    Fortschritte der Neurologie, Psychiatrie, und ihrer Grenzgebiete, 1977, Volume: 45, Issue:9

    Topics: Adolescent; Adult; Anticonvulsants; Dermatomyositis; Female; Humans; Lupus Erythematosus, Systemic;

1977
Lymphocytotoxins in epileptic patients receiving phenytoin.
    Clinical and experimental immunology, 1977, Volume: 30, Issue:1

    Topics: Antibodies; Antibodies, Antinuclear; Epilepsy; Humans; Immunoglobulin M; Lupus Erythematosus, System

1977
Adrenocortical carcinoma in a patient with systemic lupus erythematosus treated with azathioprine.
    Arthritis and rheumatism, 1979, Volume: 22, Issue:8

    Topics: Adrenal Cortex Neoplasms; Azathioprine; Humans; Lupus Erythematosus, Systemic; Male; Middle Aged; Ne

1979
Lupus-scleroderma syndrome induced by ethosuximide.
    Archives of disease in childhood, 1975, Volume: 50, Issue:8

    Topics: Adolescent; Anemia; Epilepsy, Tonic-Clonic; Ethosuximide; Female; Humans; Lupus Erythematosus, Syste

1975
[Diphenylhydantoin inducing a lupus erythematosus-like syndrome].
    Polski tygodnik lekarski (Warsaw, Poland : 1960), 1977, Aug-15, Volume: 32, Issue:33

    Topics: Adult; Diagnosis, Differential; Epilepsy; Female; Humans; Lupus Erythematosus, Systemic; Male; Middl

1977
Letter: Phenytoin interference with dexamethasone.
    JAMA, 1976, Feb-23, Volume: 235, Issue:8

    Topics: Adolescent; Dexamethasone; Drug Interactions; Female; Humans; Lupus Erythematosus, Systemic; Phenyto

1976
Antinuclear antibodies and lupus-like syndromes in children receiving anticonvulsants.
    Pediatrics, 1976, Volume: 57, Issue:4

    Topics: Adolescent; Adult; Antibodies, Antinuclear; Anticonvulsants; Child; Child, Preschool; Ethosuximide;

1976
Control of hyperkalemia with fludrocortisone in a patient with systemic lupus erythematosus.
    Clinical nephrology, 1990, Volume: 33, Issue:4

    Topics: Adolescent; Atenolol; Creatinine; Cyclosporins; Enalapril; Fludrocortisone; Humans; Hyperkalemia; Ki

1990
[Primary investigation of drug-induced lupus].
    Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae, 1988, Volume: 10, Issue:5

    Topics: Humans; Hydralazine; Isoniazid; Lupus Erythematosus, Systemic; Phenytoin

1988
[A case of systemic lupus erythematosus demonstrating basal ganglia calcifications, coronary stenosis and selective IgA deficiency].
    Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine, 1986, Volume: 75, Issue:1

    Topics: Adult; Basal Ganglia Diseases; Calcinosis; Coronary Disease; Dysgammaglobulinemia; Female; Humans; I

1986
Phenytoin removal by plasmapheresis in renal insufficiency.
    American journal of nephrology, 1986, Volume: 6, Issue:4

    Topics: Adult; Female; Humans; Kidney Failure, Chronic; Kinetics; Lupus Erythematosus, Systemic; Phenytoin;

1986
The diagnostic value of antihistone antibodies in drug-induced lupus erythematosus.
    Arthritis and rheumatism, 1985, Volume: 28, Issue:2

    Topics: Adolescent; Adult; Aged; Antibodies, Antinuclear; Autoantibodies; Child; Disopyramide; Female; Fluor

1985
[A case of drug-induced lupus].
    Recenti progressi in medicina, 1985, Volume: 76, Issue:2

    Topics: Adult; Anticonvulsants; Carbamazepine; Ethosuximide; Female; Humans; Lupus Erythematosus, Systemic;

1985
Stevens-Johnson syndrome and toxic epidermal necrolysis in a patient with systemic lupus erythematosus.
    Journal of the American Academy of Dermatology, 1985, Volume: 13, Issue:4

    Topics: Aged; Female; Humans; Lupus Erythematosus, Systemic; Phenytoin; Stevens-Johnson Syndrome; Tetracycli

1985
Carpal tunnel syndrome. First manifestation of systemic lupus erythematosus.
    JAMA, 1972, Dec-11, Volume: 222, Issue:11

    Topics: Adult; Antibodies, Antinuclear; Biopsy; Carpal Tunnel Syndrome; Female; Humans; Lupus Erythematosus,

1972
[Drug-induced lupus-nephritis light-, electron- and immunfluorescence-microscopic investigations on kidney biopsies (author's transl)].
    Verhandlungen der Deutschen Gesellschaft fur Pathologie, 1972, Volume: 56

    Topics: Adolescent; Anticonvulsants; Biopsy; Child; Drug-Related Side Effects and Adverse Reactions; Female;

1972
The interaction of lupus-inducing drugs with deoxyribonucleic acid.
    Clinical immunology and immunopathology, 1974, Volume: 3, Issue:2

    Topics: Adult; Animals; Cattle; Child; DNA; DNA, Single-Stranded; Hot Temperature; Humans; Hydralazine; Immu

1974
[Medicaments as iatrogenic factors in the onset of lupoid syndromes].
    Medicina interna, 1974, Volume: 26, Issue:1

    Topics: Adolescent; Adult; Anticonvulsants; Humans; Hydralazine; Iatrogenic Disease; Isoniazid; Lupus Erythe

1974
[Onset of systemic lupus erythematosus during long term administration of diphenyl-hydantoin].
    Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine, 1971, Sep-10, Volume: 60, Issue:9

    Topics: Adult; Biopsy; Epilepsy; Humans; Kidney; Lupus Erythematosus, Systemic; Male; Phenytoin

1971
[Neuropsychiatric manifestations of systemic lupus erythematosus].
    Nordisk psykiatrisk tidsskrift. Nordic journal of psychiatry, 1969, Volume: 23, Issue:5

    Topics: Adult; Chlorpromazine; Chlorprothixene; Female; Humans; Lupus Erythematosus, Systemic; Neurologic Ma

1969
[Correlation between systemic lupus erythematosus and anti-convulsants. Case of systemic lupus erythematosus with aggravated lupus and granulocytopenia caused by diphenyl-hydantoin].
    Naika. Internal medicine, 1970, Volume: 26, Issue:5

    Topics: Adult; Agranulocytosis; Female; Humans; Lupus Erythematosus, Systemic; Phenytoin

1970
The coincidence of Klinefelter's syndrome and systemic lupus erythematosus.
    Arthritis and rheumatism, 1969, Volume: 12, Issue:3

    Topics: Adult; Anemia, Hemolytic; Autoimmune Diseases; Chromosome Aberrations; Chromosome Disorders; Gonadal

1969
Drug-induced systemic lupus erythematosus. Primidone as a possible cause.
    JAMA, 1966, Nov-07, Volume: 198, Issue:6

    Topics: Electroencephalography; Epilepsy; Female; Humans; Hydralazine; Hydroxychloroquine; Lupus Erythematos

1966