Compounds > phenytoin
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phenytoin and Infant, Newborn, Diseases

phenytoin has been researched along with Infant, Newborn, Diseases in 46 studies

Infant, Newborn, Diseases: Diseases of newborn infants present at birth (congenital) or developing within the first month of birth. It does not include hereditary diseases not manifesting at birth or within the first 30 days of life nor does it include inborn errors of metabolism. Both HEREDITARY DISEASES and METABOLISM, INBORN ERRORS are available as general concepts.

Research Excerpts

ExcerptRelevanceReference
"To compare the efficacy of phenobarbitone and phenytoin for treatment of neonatal seizures in term and near-term neonates."9.17Phenobarbitone versus phenytoin for treatment of neonatal seizures: an open-label randomized controlled trial. ( Chawla, D; Goel, SP; Pathak, G; Pathak, U; Upadhyay, A, 2013)
" We determined the plasma levels of phenobarbital and diphenylhydantoin following initial administration and during maintenance therapy in 59 neonates with seizures."7.66Phenobarbital and diphenylhydantoin levels in neonates with seizures. ( MacDonald, H; Painter, MJ; Pippenger, C; Pitlick, W, 1978)
"Phenytoin was found in higher concentration in gray matter, whereas phenobarbital was equally distributed between gray and white matter."5.26Phenobarbital and phenytoin in neonatal seizures: metabolism and tissue distribution. ( Abern, S; Barmada, M; Carter, G; Painter, MJ; Pippenger, C; Pitlick, W; Wasterlain, C, 1981)
"To compare the efficacy of phenobarbitone and phenytoin for treatment of neonatal seizures in term and near-term neonates."5.17Phenobarbitone versus phenytoin for treatment of neonatal seizures: an open-label randomized controlled trial. ( Chawla, D; Goel, SP; Pathak, G; Pathak, U; Upadhyay, A, 2013)
" As first-line drug phenobarbital was the most common choice, it was used in 79% of cases of acute symptomatic seizures, in 63% of structural epilepsy, in 42% of genetic epilepsies."3.91Influence of etiology on treatment choices for neonatal seizures: A survey among pediatric neurologists. ( Capovilla, G; Consonni, D; De Liso, P; Di Capua, M; Dilena, R; Falsaperla, R; Pisani, F; Pruna, D; Suppiej, A; Vitaliti, G, 2019)
"We measured the apparent half-life (t50%) of phenytoin (PHT) 30 times in 16 infants (aged 2 to 36 days) who had seizures."3.66Phenytoin elimination in newborns. ( Bourgeois, BF; Dodson, WE, 1983)
" The treatment of status epilepticus with intravenous phenytoin is effective."3.66Epilepsy and pregnancy. ( Bruni, J; Willmore, LJ, 1979)
" We determined the plasma levels of phenobarbital and diphenylhydantoin following initial administration and during maintenance therapy in 59 neonates with seizures."3.66Phenobarbital and diphenylhydantoin levels in neonates with seizures. ( MacDonald, H; Painter, MJ; Pippenger, C; Pitlick, W, 1978)
"Neonatal seizures continue to present a diagnostic and therapeutic challenge to paediatricians worldwide, and are a worrying sign for both parents and clinicians alike."2.42Neonatal seizures and their treatment. ( Boylan, GB; Rennie, JM, 2003)
"Very few respondents used pyridoxine to treat recurrent seizures that were historically linked to perinatal asphyxia and hypoxic-ischaemic encephalopathy."1.33Drug treatment of neonatal seizures by neonatologists and paediatric neurologists. ( Barr, P; Carmo, KB, 2005)
" To maintain a serum level above 10 micrograms per milliliter and abolish seizure activity, it was necessary to carry out repeated serum concentration measurements, administer several loading doses, and administer an unusually large maintenance dose (25 mg per kilogram per day), divided into a short dosing interval (6 hours)."1.27High intravenous phenytoin dosage requirement in a newborn infant. ( Haberkern, CM; Hendeles, L; Neims, AH; Whelan, HT, 1983)
"Phenobarbital was the initial drug of choice and phenytoin usually the second drug."1.26Neonatal seizures: a survey of current practice. ( Boer, HR; Gal, P, 1982)
"All had central sleep apnea, three had hypoventilation, and none had obstructive apnea observed on polygraphic recordings."1.26Episodic complete airway obstruction in infants. ( Kelly, DH; Shannon, DC, 1981)
"Phenytoin was found in higher concentration in gray matter, whereas phenobarbital was equally distributed between gray and white matter."1.26Phenobarbital and phenytoin in neonatal seizures: metabolism and tissue distribution. ( Abern, S; Barmada, M; Carter, G; Painter, MJ; Pippenger, C; Pitlick, W; Wasterlain, C, 1981)

Research

Studies (46)

TimeframeStudies, this research(%)All Research%
pre-199037 (80.43)18.7374
1990's0 (0.00)18.2507
2000's3 (6.52)29.6817
2010's5 (10.87)24.3611
2020's1 (2.17)2.80

Authors

AuthorsStudies
Alix, V1
James, M1
Jackson, AH1
Visintainer, PF1
Singh, R1
Dilena, R1
De Liso, P1
Di Capua, M1
Consonni, D1
Capovilla, G1
Pisani, F1
Suppiej, A1
Vitaliti, G1
Falsaperla, R1
Pruna, D1
Pathak, G1
Upadhyay, A2
Pathak, U1
Chawla, D1
Goel, SP1
Dutta, S1
Sahu, JK1
Rennie, JM1
Boylan, GB1
JABBOUR, JT1
PANTAROTTO, MF1
Carmo, KB1
Barr, P1
Dooling, EC1
Stern, L1
Koch, S1
Göpfert-Geyer, I1
Jäger-Roman, E1
Jakob, S1
Huth, H1
Hartmann, A1
Rating, D1
Helge, H1
Whelan, HT1
Hendeles, L1
Haberkern, CM1
Neims, AH1
Bourgeois, BF2
Dodson, WE2
Colman, N1
Hettiarachchy, N1
Herbert, V1
Painter, MJ3
Albani, M1
Albengres, E1
Tillement, JP1
Ferrendelli, JA1
Zenk, KE1
Boer, HR1
Gal, P1
Kelly, DH1
Shannon, DC1
Pippenger, C2
Wasterlain, C1
Barmada, M1
Pitlick, W2
Carter, G1
Abern, S1
Pettit, RE1
Fenichel, GM1
Evans, AN1
Brooke, OG1
West, RJ1
McBride, MC1
Laroia, N1
Guillet, R1
Barry, JE1
Vassella, F1
Bruni, J1
Willmore, LJ1
MacDonald, H1
Friis, B1
Sardemann, H1
Hawkins, DF1
Holden, KR1
Freeman, JM1
Reynolds, JW1
Turnipseed, MR1
Mirkin, BL1
Lennox-Buchthal, MA1
Mountain, KR1
Hirsh, J1
Gallus, AS1
Davies, PP1
Pochedly, C1
Ente, G1
Neville, BG1
Lombroso, CT1
Solomon, GE1
Hilgartner, MW1
Kutt, H1
Windorfer, A1
Wehinger, H1
Schumacher, G1
Snodgrass, GJ1
Lund, L1
Lunde, PK2
Rane, A2
Borga, O1
Sjöqvist, F2
Jalling, B1
Yaffe, SJ1
Laurance, BM1

Reviews

7 reviews available for phenytoin and Infant, Newborn, Diseases

ArticleYear
Neonatal seizures and their treatment.
    Current opinion in neurology, 2003, Volume: 16, Issue:2

    Topics: Anticonvulsants; Brain; Humans; Infant, Newborn; Infant, Newborn, Diseases; Lidocaine; Neuronal Plas

2003
An overview of perinatal clinical pharmacology.
    Clinics in laboratory medicine, 1981, Volume: 1, Issue:2

    Topics: Abnormalities, Drug-Induced; Analgesics; Bupivacaine; Carbamazepine; Chloramphenicol; Diazepam; Digo

1981
[Epilepsies of infancy and early childhood (author's transl)].
    Schweizerische Rundschau fur Medizin Praxis = Revue suisse de medecine Praxis, 1978, Jun-06, Volume: 67, Issue:23

    Topics: Clonazepam; Electroencephalography; Epilepsy; Humans; Infant; Infant, Newborn; Infant, Newborn, Dise

1978
Neonatal seizures and their treatment.
    Clinics in perinatology, 1975, Volume: 2, Issue:1

    Topics: Anticonvulsants; Diazepam; Humans; Hypocalcemia; Hypoglycemia; Infant, Newborn; Infant, Newborn, Dis

1975
Febrile convulsions. A reappraisal.
    Electroencephalography and clinical neurophysiology, 1973, Volume: 32

    Topics: Age Factors; Animals; Animals, Newborn; Body Temperature; Brain; Brain Damage, Chronic; Child, Presc

1973
Adverse hematologic effects of drugs.
    Pediatric clinics of North America, 1972, Volume: 19, Issue:4

    Topics: Anemia, Hemolytic; Anemia, Macrocytic; Anti-Bacterial Agents; Anticonvulsants; Antidepressive Agents

1972
The treatment of status epilepticus.
    Pediatrics, 1974, Volume: 53, Issue:4

    Topics: Anti-Bacterial Agents; Anticonvulsants; Barbiturates; Brain Edema; Central Nervous System Diseases;

1974

Trials

3 trials available for phenytoin and Infant, Newborn, Diseases

ArticleYear
Phenobarbitone versus phenytoin for treatment of neonatal seizures: an open-label randomized controlled trial.
    Indian pediatrics, 2013, Volume: 50, Issue:8

    Topics: Anticonvulsants; Electroencephalography; Female; Humans; India; Infant, Newborn; Infant, Newborn, Di

2013
[Anti-epileptic agents during pregnancy. A prospective study on the course of pregnancy, malformations and child development].
    Deutsche medizinische Wochenschrift (1946), 1983, Feb-18, Volume: 108, Issue:7

    Topics: Abnormalities, Drug-Induced; Abortion, Spontaneous; Adult; Akathisia, Drug-Induced; Anencephaly; Ant

1983
Electrographic seizures in neonates correlate with poor neurodevelopmental outcome.
    Neurology, 2000, Aug-22, Volume: 55, Issue:4

    Topics: Anticonvulsants; Asphyxia Neonatorum; Demography; Developmental Disabilities; Electroencephalography

2000

Other Studies

36 other studies available for phenytoin and Infant, Newborn, Diseases

ArticleYear
Efficacy of Fosphenytoin as First-Line Antiseizure Medication for Neonatal Seizures Compared to Phenobarbital.
    Journal of child neurology, 2021, Volume: 36, Issue:1

    Topics: Anticonvulsants; Child, Preschool; Cohort Studies; Female; Humans; Infant; Infant, Newborn; Infant,

2021
Influence of etiology on treatment choices for neonatal seizures: A survey among pediatric neurologists.
    Brain & development, 2019, Volume: 41, Issue:7

    Topics: Anticonvulsants; Child, Preschool; Electroencephalography; Epilepsy; Female; Humans; Infant; Infant,

2019
Anticonvulsants for neonates: high time we were seized of the matter.
    Indian pediatrics, 2013, Volume: 50, Issue:8

    Topics: Anticonvulsants; Female; Humans; Infant, Newborn, Diseases; Male; Phenobarbital; Phenytoin; Seizures

2013
Neonatal seizures: continued debate on phenobarbitone versus phenytoin.
    Indian pediatrics, 2013, Volume: 50, Issue:12

    Topics: Anticonvulsants; Female; Humans; Infant, Newborn, Diseases; Male; Phenobarbital; Phenytoin; Seizures

2013
Reply: To PMID 23502660.
    Indian pediatrics, 2013, Volume: 50, Issue:12

    Topics: Anticonvulsants; Female; Humans; Infant, Newborn, Diseases; Male; Phenobarbital; Phenytoin; Seizures

2013
THE INFANT WITH EPILEPSY.
    Southwestern medicine, 1963, Volume: 44

    Topics: Acetazolamide; Adrenocorticotropic Hormone; Anticonvulsants; Barbiturates; Birth Injuries; Classific

1963
[A CASE OF TRANSITORY MEDULLARY APLASIA IN A NEWBORN DUE TO ANTICONVULSANT DRUGS ADMINISTERED TO THE MOTHER DURING THE ENTIRE PREGNANCY].
    La Clinica ostetrica e ginecologica, 1965, Volume: 67

    Topics: Anemia; Anemia, Aplastic; Anticonvulsants; Humans; Infant, Newborn; Infant, Newborn, Diseases; Mothe

1965
Drug treatment of neonatal seizures by neonatologists and paediatric neurologists.
    Journal of paediatrics and child health, 2005, Volume: 41, Issue:7

    Topics: Anticonvulsants; Benzodiazepines; Humans; Hypoxia-Ischemia, Brain; Infant, Newborn; Infant, Newborn,

2005
Hypomagnesemia with convulsions in a newborn infant. Report of a case associated with maternal hypophosphatemia.
    Canadian Medical Association journal, 1967, Sep-30, Volume: 97, Issue:14

    Topics: Calcium; Female; Humans; Hypocalcemia; Hypophosphatemia, Familial; Infant, Newborn; Infant, Newborn,

1967
High intravenous phenytoin dosage requirement in a newborn infant.
    Neurology, 1983, Volume: 33, Issue:1

    Topics: Female; Humans; Infant, Newborn; Infant, Newborn, Diseases; Kinetics; Phenytoin; Seizures

1983
Phenytoin elimination in newborns.
    Neurology, 1983, Volume: 33, Issue:2

    Topics: Age Factors; Half-Life; Humans; Infant, Newborn; Infant, Newborn, Diseases; Kinetics; Phenytoin; Sei

1983
Detection of a milk factor that facilitates folate uptake by intestinal cells.
    Science (New York, N.Y.), 1981, Mar-27, Volume: 211, Issue:4489

    Topics: Animals; Calcium; Carrier Proteins; Cattle; Edetic Acid; Female; Folate Receptors, GPI-Anchored; Fol

1981
General principles of treatment: status epilepticus in neonates.
    Advances in neurology, 1983, Volume: 34

    Topics: Diagnosis, Differential; Diazepam; Humans; Infant, Newborn; Infant, Newborn, Diseases; Phenobarbital

1983
Phenytoin in infancy and childhood.
    Advances in neurology, 1983, Volume: 34

    Topics: Humans; Infant; Infant, Newborn; Infant, Newborn, Diseases; Injections, Intravenous; Phenytoin; Seiz

1983
Phenytoin in pregnancy: a review of the reported risks.
    Biological research in pregnancy and perinatology, 1983, Volume: 4, Issue:2

    Topics: Abnormalities, Drug-Induced; Blood Coagulation Disorders; Epilepsy; Female; Humans; Infant; Infant,

1983
Phenobarbital and phenytoin in neonatal seizures.
    Neurology, 1982, Volume: 32, Issue:12

    Topics: Humans; Infant, Newborn; Infant, Newborn, Diseases; Phenobarbital; Phenytoin; Seizures

1982
Neonatal seizures: a survey of current practice.
    Clinical pediatrics, 1982, Volume: 21, Issue:8

    Topics: Blood Glucose; Calcium; Diagnosis, Differential; Dose-Response Relationship, Drug; Electrolytes; Eva

1982
Episodic complete airway obstruction in infants.
    Pediatrics, 1981, Volume: 67, Issue:6

    Topics: Airway Obstruction; Drug Therapy, Combination; Female; Humans; Infant; Infant, Newborn; Infant, Newb

1981
Phenobarbital and phenytoin in neonatal seizures: metabolism and tissue distribution.
    Neurology, 1981, Volume: 31, Issue:9

    Topics: Brain; Drug Therapy, Combination; Half-Life; Humans; Infant, Newborn; Infant, Newborn, Diseases; Phe

1981
Benign familial neonatal seizures.
    Archives of neurology, 1980, Volume: 37, Issue:1

    Topics: Electroencephalography; Humans; Infant; Infant, Newborn; Infant, Newborn, Diseases; Male; Pedigree;

1980
The ingestion by pregnant women of substances toxic to the foetus.
    The Practitioner, 1980, Volume: 224, Issue:1341

    Topics: Abnormalities, Drug-Induced; Barbiturates; Clitoris; Diazepam; Disorders of Sex Development; Doxylam

1980
Epilepsy in childhood.
    The New Zealand medical journal, 1978, Nov-22, Volume: 88, Issue:624

    Topics: Anticonvulsants; Child; Epilepsy; Epilepsy, Absence; Epilepsy, Tonic-Clonic; Humans; Infant; Infant,

1978
Epilepsy and pregnancy.
    The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques, 1979, Volume: 6, Issue:3

    Topics: Abnormalities, Drug-Induced; Anticonvulsants; Blood Coagulation Disorders; Chromosome Aberrations; C

1979
Phenobarbital and diphenylhydantoin levels in neonates with seizures.
    The Journal of pediatrics, 1978, Volume: 92, Issue:2

    Topics: Administration, Oral; Female; Half-Life; Humans; Infant, Newborn; Infant, Newborn, Diseases; Infusio

1978
Neonatal hypocalcaemia after intrauterine exposure to anticonvulsant drugs.
    Archives of disease in childhood, 1977, Volume: 52, Issue:3

    Topics: Adult; Female; Humans; Hypocalcemia; Infant, Newborn; Infant, Newborn, Diseases; Male; Maternal-Feta

1977
Teratogens in the human: current problems.
    Journal of clinical pathology. Supplement (Royal College of Pathologists), 1976, Volume: 10

    Topics: Abnormalities, Drug-Induced; Barbiturates; Contraceptives, Oral; Ethanol; Female; Fetal Diseases; Hu

1976
Adrenal cortical function in abnormal newborn infants.
    Journal of steroid biochemistry, 1975, Volume: 6, Issue:5

    Topics: Adrenal Cortex; Adrenal Cortex Hormones; Adrenal Glands; Barbiturates; Female; Fetal Diseases; Gesta

1975
Neonatal coagulation defect due to anticonvulsant drug treatment in pregnancy.
    Lancet (London, England), 1970, Feb-07, Volume: 1, Issue:7641

    Topics: Adolescent; Adult; Anticonvulsants; Barbiturates; Blood Coagulation Disorders; Blood Coagulation Tes

1970
Coagulation defect due to anticonvulsant drug treatment in pregnancy.
    Lancet (London, England), 1970, Feb-21, Volume: 1, Issue:7643

    Topics: Adult; Blood Coagulation Disorders; Epilepsy; Female; Humans; Infant, Newborn; Infant, Newborn, Dise

1970
The origin of infantile spasms: evidence from a case of hydranencephaly.
    Developmental medicine and child neurology, 1972, Volume: 14, Issue:5

    Topics: Anencephaly; Cerebral Ventriculography; Electroencephalography; Electromyography; Female; Humans; Hy

1972
Coagulation defects caused by diphenylhydantoin.
    Neurology, 1972, Volume: 22, Issue:11

    Topics: Animals; Blood Coagulation Disorders; Blood Coagulation Factors; Cats; Factor IX; Factor V; Factor V

1972
[Symptoms and therapy for acute and subacute digitalis poisoning in newborn and older infants].
    Klinische Padiatrie, 1973, Volume: 185, Issue:2

    Topics: Acute Disease; Biological Transport, Active; Digoxin; Female; Humans; Infant, Newborn; Infant, Newbo

1973
Seizures in newborn infants.
    Developmental medicine and child neurology, 1974, Volume: 16, Issue:1

    Topics: Birth Injuries; Brain; Calcium; Diazepam; Gluconates; Glucose; Humans; Hypocalcemia; Hypoxia; Infant

1974
Plasma protein binding, plasma concentrations, and effects of diphenylhydantoin in man.
    Annals of the New York Academy of Sciences, 1971, Jul-06, Volume: 179

    Topics: Blood; Blood Proteins; Epilepsy; Epilepsy, Tonic-Clonic; Female; Humans; Hyperbilirubinemia; In Vitr

1971
Plasma protein binding of diphenylhydantoin in normal and hyperbilirubinemic infants.
    The Journal of pediatrics, 1971, Volume: 78, Issue:5

    Topics: Bilirubin; Binding Sites; Blood Proteins; Carbon Isotopes; Desipramine; Female; Filtration; Humans;

1971
'Idiopathic epilepsy'.
    The Practitioner, 1970, Volume: 205, Issue:227

    Topics: Epilepsy; Female; Humans; Infant, Newborn; Infant, Newborn, Diseases; Phenytoin; Primidone; Prognosi

1970