phenytoin has been researched along with Hypoxia in 67 studies
Hypoxia: Sub-optimal OXYGEN levels in the ambient air of living organisms.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To study the effect of plateau hypoxia on the concentration of P-glycoprotein (P-gp) substrate phenytoin, Wistar rats are randomly divided into the control group and the hypoxic group, including P-gp inhibited groups respectively." | 7.96 | Enhanced P-glycoprotein expression under high-altitude hypoxia contributes to increased phenytoin levels and reduced clearance in rats. ( Wang, R; Zhang, J; Zhang, M, 2020) |
| "The aim of the present study was to test the hypothesis that the natural antioxidant melatonin (MEL) and the synthetic antioxidant stobadine (STO) could reduce the incidence of maternal and embryofoetal toxicity in rats due to intrauterine hypoxia." | 7.72 | Effect of melatonin and stobadine on maternal and embryofoetal toxicity in rats due to intrauterine hypoxia induced by phenytoin administration. ( Brucknerová, I; Dubovický, M; Juránek, I; Mach, M; Navarová, J; Soltés, L; Ujházy, E; Zeman, M, 2004) |
| "The aim of this study was to investigate if phenytoin has the capacity to induce embryonic hypoxia mediated via adverse effects on the embryonic heart." | 7.69 | Initiation of phenytoin teratogenesis: pharmacologically induced embryonic bradycardia and arrhythmia resulting in hypoxia and possible free radical damage at reoxygenation. ( Azarbayjani, F; Danielsson, BR; Sköld, AC; Webster, WS, 1997) |
| "PHT dose-dependently increased the hypoxia staining (6- and 11-fold after maternal dosing of 100 and 150 mg/kg, respectively) during the period I(Kr) is expressed and functional (GD 10)." | 5.33 | Phenytoin teratogenicity: hypoxia marker and effects on embryonic heart rhythm suggest an hERG-related mechanism. ( Azarbayjani, F; Blomgren, B; Danielsson, BR; Danielsson, C; Johansson, A; Sköld, AC, 2005) |
| "In the treatment of cerebral infarction, it is important to select drugs for inhibiting development of the pathology." | 5.27 | [Superior protective activity of phenytoin against hypoxia in pharmacological screening test]. ( Imaizumi, S; Kinouchi, H; Suzuki, J; Yoshimoto, T, 1986) |
| "To study the effect of plateau hypoxia on the concentration of P-glycoprotein (P-gp) substrate phenytoin, Wistar rats are randomly divided into the control group and the hypoxic group, including P-gp inhibited groups respectively." | 3.96 | Enhanced P-glycoprotein expression under high-altitude hypoxia contributes to increased phenytoin levels and reduced clearance in rats. ( Wang, R; Zhang, J; Zhang, M, 2020) |
| "An infant who was exposed to phenytoin as monotherapy throughout pregnancy was born with the following abnormalities: midface hypoplasia, digit hypoplasia with syndactyly in the hands and feet, meningomyelocele, talipes equinovarus, and a long skin pedicle on the back." | 3.72 | Multiple congenital anomalies associated with in utero exposure of phenytoin: possible hypoxic ischemic mechanism? ( Holmes, LB; Huang, T; Lyon, HM, 2003) |
| "The present pre- and postnatal study was carried out to investigate the effect of melatonin (MEL), a potent antioxidant, on biochemical variables in the in vivo model of intrauterine hypoxia in rats." | 3.72 | Effect of melatonin on biochemical variables induced by phenytoin in organs of mothers, foetuses and offsprings of rats. ( Dubovický, M; Mach, M; Navarová, J; Ujházy, E, 2004) |
| "The aim of the present study was to test the hypothesis that the natural antioxidant melatonin (MEL) and the synthetic antioxidant stobadine (STO) could reduce the incidence of maternal and embryofoetal toxicity in rats due to intrauterine hypoxia." | 3.72 | Effect of melatonin and stobadine on maternal and embryofoetal toxicity in rats due to intrauterine hypoxia induced by phenytoin administration. ( Brucknerová, I; Dubovický, M; Juránek, I; Mach, M; Navarová, J; Soltés, L; Ujházy, E; Zeman, M, 2004) |
| "The aim of this study was to investigate if phenytoin has the capacity to induce embryonic hypoxia mediated via adverse effects on the embryonic heart." | 3.69 | Initiation of phenytoin teratogenesis: pharmacologically induced embryonic bradycardia and arrhythmia resulting in hypoxia and possible free radical damage at reoxygenation. ( Azarbayjani, F; Danielsson, BR; Sköld, AC; Webster, WS, 1997) |
| "Phenytoin sodium was evaluated for its effect on the development and intensity of acute mountain sickness (AMS) because of its ability to reduce intracellular Na+ concentrations in brain and thereby minimize any tendency to increase cellular volume, a hypothetical cause of AMS." | 2.65 | Phenytoin: ineffective against acute mountain sickness. ( Burse, RL; Landowne, M; Maher, JT; Young, AJ, 1982) |
| " Instead, single dosing on specific days is proposed to be a better way to characterize the teratogenic potential of Ikr blocking drugs." | 2.44 | Embryonic cardiac arrhythmia and generation of reactive oxygen species: common teratogenic mechanism for IKr blocking drugs. ( Danielsson, BR; Danielsson, C; Nilsson, MF, 2007) |
| "Phenytoin is a known human teratogen with unknown etiology." | 1.62 | The effect of phenytoin on embryonic heart rate in Vivo. ( Ababneh, D; Abela, D; Farrell, E; Hegedus, E; Howe, AM; Ritchie, HE, 2021) |
| "A number of drugs induced arrhythmias and these appeared to be related to either sodium channel blockade, which resulted in a double atrial beat for each ventricular beat, or I(Kr)/hERG blockade, which caused irregular atrial and ventricular beats." | 1.36 | The effect of drugs with ion channel-blocking activity on the early embryonic rat heart. ( Ababneh, D; Abela, D; Carlsson, K; Gavin, C; Khan, MK; Nilsson, MF; Ritchie, H; Webster, WS, 2010) |
| "PHT dose-dependently increased the hypoxia staining (6- and 11-fold after maternal dosing of 100 and 150 mg/kg, respectively) during the period I(Kr) is expressed and functional (GD 10)." | 1.33 | Phenytoin teratogenicity: hypoxia marker and effects on embryonic heart rhythm suggest an hERG-related mechanism. ( Azarbayjani, F; Blomgren, B; Danielsson, BR; Danielsson, C; Johansson, A; Sköld, AC, 2005) |
| "In the treatment of cerebral infarction, it is important to select drugs for inhibiting development of the pathology." | 1.27 | [Superior protective activity of phenytoin against hypoxia in pharmacological screening test]. ( Imaizumi, S; Kinouchi, H; Suzuki, J; Yoshimoto, T, 1986) |
| "The effect of temperature, either along or in combination with pentobarbital or phenytoin, on survival time in the hypoxic (Flo2 = 0." | 1.26 | Influence of hypothermia or hyperthermia alone or in combination with pentobarbital or phenytoin on survival time in hypoxic mice. ( Artru, AA; Michenfelder, JD, 1981) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 41 (61.19) | 18.7374 |
| 1990's | 8 (11.94) | 18.2507 |
| 2000's | 11 (16.42) | 29.6817 |
| 2010's | 3 (4.48) | 24.3611 |
| 2020's | 4 (5.97) | 2.80 |
| Authors | Studies |
|---|---|
| Kane, JM | 1 |
| Baron, BM | 1 |
| Dudley, MW | 1 |
| Sorensen, SM | 1 |
| Staeger, MA | 1 |
| Miller, FP | 1 |
| Ritchie, HE | 1 |
| Abela, D | 2 |
| Ababneh, D | 2 |
| Howe, AM | 1 |
| Farrell, E | 1 |
| Hegedus, E | 1 |
| Masoomzadeh, F | 1 |
| Ali Khan, B | 1 |
| M Alshahrani, S | 1 |
| Alqahtani, A | 1 |
| Ebrahimzadeh, MA | 1 |
| Khalili, M | 1 |
| Nakatomi, M | 1 |
| Ludwig, KU | 1 |
| Knapp, M | 1 |
| Kist, R | 1 |
| Lisgo, S | 1 |
| Ohshima, H | 1 |
| Mangold, E | 1 |
| Peters, H | 1 |
| Zhang, J | 2 |
| Zhang, M | 1 |
| Wang, R | 1 |
| Chernoff, N | 1 |
| Rogers, JM | 1 |
| Ritchie, H | 1 |
| Gavin, C | 1 |
| Nilsson, MF | 2 |
| Khan, MK | 1 |
| Carlsson, K | 1 |
| Webster, WS | 2 |
| Li, XY | 1 |
| Liu, YN | 1 |
| Yuan, M | 1 |
| Li, YP | 1 |
| Yang, YZ | 1 |
| Zhu, JB | 1 |
| Rekling, JC | 1 |
| VANLIERE, EJ | 1 |
| NAIMAN, JG | 1 |
| WILLIAMS, HL | 1 |
| Lyon, HM | 1 |
| Holmes, LB | 1 |
| Huang, T | 1 |
| Dubovický, M | 3 |
| Ujházy, E | 3 |
| Kovacovský, P | 1 |
| Navarová, J | 3 |
| Juráni, M | 1 |
| Soltés, L | 2 |
| Mach, M | 2 |
| Juránek, I | 1 |
| Brucknerová, I | 1 |
| Zeman, M | 1 |
| Hobgood, C | 1 |
| Hevia, A | 1 |
| Hinchey, P | 1 |
| Danielsson, BR | 4 |
| Johansson, A | 1 |
| Danielsson, C | 2 |
| Azarbayjani, F | 3 |
| Blomgren, B | 1 |
| Sköld, AC | 2 |
| Asimiadou, S | 1 |
| Bittigau, P | 1 |
| Felderhoff-Mueser, U | 1 |
| Manthey, D | 1 |
| Sifringer, M | 1 |
| Pesditschek, S | 1 |
| Dzietko, M | 1 |
| Kaindl, AM | 1 |
| Pytel, M | 1 |
| Studniarczyk, D | 1 |
| Mozrzymas, JW | 1 |
| Ikonomidou, C | 1 |
| Faustino, EV | 2 |
| Donnelly, DF | 2 |
| Ishay, JS | 1 |
| Ribak, JP | 1 |
| Noy-Man, Y | 1 |
| Avgar, DM | 1 |
| Shirin, ME | 1 |
| Bukowskyj, M | 1 |
| Nakatsu, K | 1 |
| Munt, PW | 1 |
| Aldrete, JA | 1 |
| Cubillos, P | 1 |
| Burse, RL | 1 |
| Landowne, M | 1 |
| Young, AJ | 1 |
| Maher, JT | 1 |
| Ostrovskaia, RU | 1 |
| Artru, AA | 1 |
| Michenfelder, JD | 1 |
| Watson, GB | 1 |
| Lanthorn, TH | 1 |
| Fern, R | 1 |
| Ransom, BR | 1 |
| Stys, PK | 1 |
| Waxman, SG | 1 |
| Jund, R | 1 |
| Kastenbauer, E | 1 |
| Saito, Y | 1 |
| Hashimoto, T | 1 |
| Iwata, H | 1 |
| Takahashi, K | 1 |
| Fukumizu, M | 1 |
| Sasaki, M | 1 |
| Hanaoka, S | 1 |
| Sugai, K | 1 |
| Bechtel, P | 1 |
| Delafin, C | 1 |
| Bechtel, Y | 1 |
| Nataf, N | 1 |
| Gourmel, B | 1 |
| Rossignol, P | 1 |
| Bayer, AS | 1 |
| Targan, SR | 1 |
| Pitchon, HE | 1 |
| Guze, LB | 1 |
| Mentzer, RM | 1 |
| Alegre, C | 1 |
| Nolan, SP | 1 |
| Klein, SM | 1 |
| Potter, PE | 1 |
| Detwiler, P | 1 |
| Thorne, B | 1 |
| Moskal, JR | 1 |
| Magalini, SI | 1 |
| Sabato, AF | 1 |
| Pala, F | 1 |
| Imaizumi, S | 2 |
| Suzuki, J | 2 |
| Kinouchi, H | 2 |
| Yoshimoto, T | 2 |
| Fahn, S | 1 |
| du Souich, P | 1 |
| Varin, F | 1 |
| Courteau, H | 1 |
| Wohns, RN | 1 |
| Colpitts, M | 1 |
| Clement, T | 1 |
| Karuza, A | 1 |
| Blackett, WB | 1 |
| Foutch, R | 1 |
| Larson, E | 1 |
| Aitkenhead, A | 1 |
| Selzer, A | 1 |
| Cohn, KE | 1 |
| Pincus, JH | 2 |
| Grove, I | 1 |
| Marino, BB | 1 |
| Glaser, GE | 1 |
| Mason, DT | 1 |
| Zelis, R | 1 |
| Lee, G | 1 |
| Hughes, JL | 1 |
| Spann, JF | 1 |
| Amsterdam, EA | 1 |
| Hadfield, MG | 1 |
| Tchicaloff, M | 1 |
| Hensel, G | 1 |
| Gettes, LS | 1 |
| Clayton, BD | 1 |
| Puro, DG | 1 |
| Woodward, DJ | 1 |
| Honda, Y | 1 |
| Podos, SM | 1 |
| Becker, B | 1 |
| Snodgrass, GJ | 1 |
| Hondeghem, LM | 1 |
| Grant, AO | 1 |
| Jensen, RA | 1 |
| Moss, G | 1 |
| Katz, RL | 1 |
| Bigger, JT | 2 |
| Lewartowski, B | 1 |
| Kwiatkowska, B | 1 |
| Patton, RD | 1 |
| Bassett, AL | 1 |
| Hoffman, BF | 1 |
| Mckenna, G | 1 |
| Engle, RP | 1 |
| Brooks, H | 1 |
| Dalen, J | 1 |
| Kaufmann, G | 1 |
| Weber-Eggenberger, S | 1 |
| Wilhjelm, B | 1 |
| Langgård, H | 1 |
14 reviews available for phenytoin and Hypoxia
| Article | Year |
|---|---|
Hypoxia and the Edema Syndrome: elucidation of a mechanism of teratogenesis.
Topics: Abnormalities, Drug-Induced; Animals; Blister; Chick Embryo; Cocaine; Edema; Epinephrine; Hematoma; | 2010 |
RESISTANCE TO HYPOXIA.
Topics: Acclimatization; Blood Transfusion; Chlorpromazine; Dietary Carbohydrates; Endocrine Glands; Enzymes | 1964 |
Embryonic cardiac arrhythmia and generation of reactive oxygen species: common teratogenic mechanism for IKr blocking drugs.
Topics: Abnormalities, Drug-Induced; Animals; Anti-Arrhythmia Agents; Anticonvulsants; Arrhythmias, Cardiac; | 2007 |
Theophylline reassessed.
Topics: Acidosis; Aging; Allopurinol; Animals; Anti-Bacterial Agents; Breast Feeding; Bronchodilator Agents; | 1984 |
Apneustic breathing in children with brainstem damage due to hypoxic-ischemic encephalopathy.
Topics: Brain; Brain Diseases; Brain Ischemia; Brain Stem; Child, Preschool; Dose-Response Relationship, Dru | 1999 |
[Cerebral protection].
Topics: Animals; Barbiturates; Brain Ischemia; Diuretics; Fatty Acids, Nonesterified; Humans; Hypothermia, I | 1986 |
Posthypoxic action myoclonus: literature review update.
Topics: Adult; Clonazepam; Coma; Electroencephalography; Female; Functional Laterality; Heart Arrest; Humans | 1986 |
Treatment of ventricular extrasystoles and tachyarrhythmias in acute myocardial infarction.
Topics: Acidosis; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Cardiac Complexes, Premature; Electric Count | 1970 |
Current concepts and treatment of digitalis toxicity.
Topics: Adenosine Triphosphatases; Arrhythmias, Cardiac; Binding Sites; Biological Transport; Calcium; Catec | 1971 |
[Modern treatment of cardiac arrhythmias].
Topics: Adrenergic beta-Antagonists; Arrhythmias, Cardiac; Bradycardia; Cell Membrane Permeability; Digitali | 1971 |
The electrophysiologic effects of antiarrhythmic drugs.
Topics: Acetylcholine; Acidosis; Action Potentials; Adrenergic beta-Antagonists; Arrhythmias, Cardiac; Atrop | 1971 |
Cardiac arrhythmias during anesthesia and operation.
Topics: Acidosis, Respiratory; Age Factors; Anesthesia; Anesthetics; Animals; Arrhythmia, Sinus; Arrhythmias | 1970 |
[Cellular mechanisms of the etiology of cardiac rhythm disturbances and of the action of basic anti-arrhythmia drugs].
Topics: Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Biological Transport; Biological Transport, Active; Ce | 1970 |
Management of arrhythmias in acute myocardial infarction.
Topics: Acid-Base Equilibrium; Adams-Stokes Syndrome; Arrhythmias, Cardiac; Atropine; Bradycardia; Cardiac O | 1971 |
2 trials available for phenytoin and Hypoxia
| Article | Year |
|---|---|
Phenytoin: ineffective against acute mountain sickness.
Topics: Acute Disease; Adult; Aerospace Medicine; Altitude Sickness; Clinical Trials as Topic; Double-Blind | 1982 |
Phenytoin and acute mountain sickness on Mount Everest.
Topics: Acute Disease; Adult; Altitude; Altitude Sickness; Clinical Trials as Topic; Double-Blind Method; Hu | 1986 |
51 other studies available for phenytoin and Hypoxia
| Article | Year |
|---|---|
2,4-Dihydro-3H-1,2,4-triazol-3-ones as anticonvulsant agents.
Topics: Animals; Anticonvulsants; Chemical Phenomena; Chemistry, Physical; Gerbillinae; Hippocampus; Hypoxia | 1990 |
The effect of phenytoin on embryonic heart rate in Vivo.
Topics: Abnormalities, Drug-Induced; Animals; Female; Heart; Heart Rate; Hyperglycemia; Hypoxia; Phenytoin; | 2021 |
Protective effects of rutin and chlorogenic acid against antihypoxic conditions in mice.
Topics: Animals; Chlorogenic Acid; Dose-Response Relationship, Drug; Hypoxia; Mice; Molecular Structure; Oxy | 2021 |
Topics: Animals; Bone Morphogenetic Protein 4; Cleft Lip; Female; Gene Expression Regulation, Developmental; | 2020 |
Enhanced P-glycoprotein expression under high-altitude hypoxia contributes to increased phenytoin levels and reduced clearance in rats.
Topics: Altitude Sickness; Animals; ATP Binding Cassette Transporter, Subfamily B; Blood-Brain Barrier; Brai | 2020 |
The effect of drugs with ion channel-blocking activity on the early embryonic rat heart.
Topics: Abnormalities, Drug-Induced; Animals; Arrhythmias, Cardiac; Bradycardia; Embryo Culture Techniques; | 2010 |
[Effect of high altitude hypoxia on the activity and protein expression of CYP2C9 and CYP2C19].
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Administration, Oral; Altitude; Animals; Cytochrome P-450 E | 2012 |
Neuroprotective effects of anticonvulsants in rat hippocampal slice cultures exposed to oxygen/glucose deprivation.
Topics: Acetates; Amines; Animals; Anticonvulsants; Carbamates; Carbamazepine; Cell Death; Cells, Cultured; | 2003 |
EFFECTS OF DIPHENYLHYDANTOIN ON THE DURATION OF RESPIRATORY ACTIVITY DURING ANOXIA.
Topics: Anticonvulsants; Cats; Cell Respiration; Decerebrate State; Electroencephalography; Guinea Pigs; Hyp | 1964 |
Multiple congenital anomalies associated with in utero exposure of phenytoin: possible hypoxic ischemic mechanism?
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adult; Anticonvulsants; Epilepsy; Female; Gest | 2003 |
Effect of melatonin on neurobehavioral dysfunctions induced by intrauterine hypoxia in rats.
Topics: Analysis of Variance; Animals; Behavior, Animal; Female; Hypoxia; Melatonin; Oxidative Stress; Pheny | 2004 |
Effect of melatonin on biochemical variables induced by phenytoin in organs of mothers, foetuses and offsprings of rats.
Topics: Acetylglucosaminidase; Analysis of Variance; Animals; Animals, Newborn; Anticonvulsants; Female; Glu | 2004 |
Effect of melatonin and stobadine on maternal and embryofoetal toxicity in rats due to intrauterine hypoxia induced by phenytoin administration.
Topics: Abnormalities, Drug-Induced; Analysis of Variance; Animals; Animals, Newborn; Anticonvulsants; Body | 2004 |
Profiles in patient safety: when an error occurs.
Topics: Acetates; Aged; Amines; Analgesics; Anticonvulsants; Cyclohexanecarboxylic Acids; Diabetic Neuropath | 2004 |
Phenytoin teratogenicity: hypoxia marker and effects on embryonic heart rhythm suggest an hERG-related mechanism.
Topics: Animals; Anticonvulsants; Cation Transport Proteins; Ether-A-Go-Go Potassium Channels; Female; Heart | 2005 |
Protection with estradiol in developmental models of apoptotic neurodegeneration.
Topics: Animals; Animals, Newborn; Apoptosis; Bicuculline; Blotting, Western; Brain; Caenorhabditis elegans | 2005 |
An important functional role of persistent Na+ current in carotid body hypoxia transduction.
Topics: Action Potentials; Animals; Carotid Body; Catecholamines; Chemoreceptor Cells; Dose-Response Relatio | 2006 |
Lamotrigine and phenytoin, but not amiodarone, impair peripheral chemoreceptor responses to hypoxia.
Topics: Action Potentials; Amiodarone; Animals; Anticonvulsants; Chemoreceptor Cells; Female; Hypercapnia; H | 2006 |
Hornets (Hymenoptera, Vespinae) living at simulated high altitude: the combined effects of low pressure, hypoxia, light, hyperkinesis and drugs on behavior and survival.
Topics: Allopurinol; Altitude; Animals; Atmospheric Pressure; Behavior, Animal; Female; Fertility; Humans; H | 1982 |
Phenytoin improves hemodynamic tolerance and survival after severe hypoxia.
Topics: Anesthesia, General; Animals; Blood Pressure; Heart Rate; Hemodynamics; Hypoxia; Ketamine; Phenytoin | 1984 |
[Mechanism of antihypoxic effect of depakine].
Topics: 4-Aminobutyrate Transaminase; Aminooxyacetic Acid; Animals; Brain; Dose-Response Relationship, Drug; | 1982 |
Influence of hypothermia or hyperthermia alone or in combination with pentobarbital or phenytoin on survival time in hypoxic mice.
Topics: Animals; Body Temperature; Brain; Energy Metabolism; Hypothermia, Induced; Hypoxia; Lactates; Lactic | 1981 |
Phenytoin delays ischemic depolarization, but cannot block its long-term consequences, in the rat hippocampal slice.
Topics: Animals; Brain Ischemia; Disease Models, Animal; Dose-Response Relationship, Drug; Glucose; Hippocam | 1995 |
Pharmacological protection of CNS white matter during anoxia: actions of phenytoin, carbamazepine and diazepam.
Topics: Action Potentials; Animals; Axons; Carbamazepine; Diazepam; Dose-Response Relationship, Drug; Female | 1993 |
Susceptibility of isolated rat facial nerve to anaerobic stress.
Topics: Action Potentials; Anaerobiosis; Anesthetics, Local; Animals; Anticonvulsants; Cyanides; Disease Mod | 1997 |
Initiation of phenytoin teratogenesis: pharmacologically induced embryonic bradycardia and arrhythmia resulting in hypoxia and possible free radical damage at reoxygenation.
Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Bradycardia; Cell Culture Techniques; Dose-Re | 1997 |
Pharmacologically induced embryonic dysrhythmia and episodes of hypoxia followed by reoxygenation: a common teratogenic mechanism for antiepileptic drugs?
Topics: Abnormalities, Drug-Induced; Animals; Anti-Arrhythmia Agents; Anticonvulsants; Arrhythmias, Cardiac; | 1998 |
[Induction of cytochrome P-450 and b5 of the mouse liver by phenytoin during chronic hypoxia (Fi02 : 0,08)].
Topics: Animals; Biotransformation; Cytochrome P-450 Enzyme System; Cytochromes; Enzyme Induction; Glucose-6 | 1976 |
Pharmacological actions on hypoxic increase of rat brain cortex extracellular K+ ion.
Topics: Animals; Cerebral Cortex; Extracellular Space; Hypoxia; Male; Phenytoin; Potassium; Propranolol; Pyr | 1978 |
Dilantin toxicity: miliary pulmonary infiltrates and hypoxemia.
Topics: Humans; Hypoxia; Lung Diseases, Obstructive; Male; Middle Aged; Phenytoin | 1976 |
Effects of diphenylhydantoin (Dilantin) on the pulmonary circulation.
Topics: Animals; Dogs; Hypoxia; Phenytoin; Pulmonary Circulation; Vascular Resistance | 1975 |
Letter: Dilantin therapy.
Topics: Female; Folic Acid; Humans; Hypoxia; Phenytoin; Pregnancy | 1976 |
Diphenylhydantoin attenuates hypoxia-induced release of [3H]glutamate from rat hippocampal slices.
Topics: Animals; Calcium; Electric Stimulation; Glutamates; Glutamic Acid; Hippocampus; Hypoxia; In Vitro Te | 1991 |
Superior protective effects of phenytoin against hypoxia in a pharmacological screening test.
Topics: Animals; Brain; Cerebral Infarction; Hypoxia; Kinetics; Male; Mice; Mice, Inbred Strains; Oxygen Con | 1988 |
[Superior protective activity of phenytoin against hypoxia in pharmacological screening test].
Topics: Animals; Atmosphere Exposure Chambers; Cerebral Infarction; Drug Evaluation, Preclinical; Hypoxia; M | 1986 |
Effect of hypercapnia and/or hypoxemia and metabolic acidosis on kinetics and concentrations of phenytoin in the cerebrospinal fluid of conscious rabbits.
Topics: Acidosis; Animals; Carbon Dioxide; Hypoxia; Kinetics; Male; Metabolic Clearance Rate; Phenytoin; Rab | 1986 |
Cerebral protection.
Topics: Adrenal Cortex Hormones; Barbiturates; Blood Glucose; Brain Edema; Brain Ischemia; Calcium Channel B | 1986 |
Studies on the mechanism of action of diphenylhydantoin.
Topics: Adenosine Triphosphatases; Animals; Biological Transport; Crustacea; Cyanides; Hypoxia; Neurons; Oua | 1970 |
Uptake and binding of catecholamines. Effect of diphenylhydantoin and a new mechanism of action.
Topics: Adenosine Triphosphatases; Animals; Basal Ganglia; Brain; Carbon Isotopes; Caudate Nucleus; Dopamine | 1972 |
[Epilepsy and perinatal injury].
Topics: Adolescent; Adrenocorticotropic Hormone; Barbiturates; Birth Injuries; Brain Diseases; Cerebral Hemo | 1973 |
Reduction of digitalis glycoside intoxication by rational dosing procedures.
Topics: Age Factors; Arrhythmias, Cardiac; Creatinine; Digitoxin; Digoxin; Dose-Response Relationship, Drug; | 1974 |
Effects of diphenylhydantoin on activity of rat cerebellar Purkinje cells.
Topics: Action Potentials; Animals; Behavior, Animal; Blood Pressure; Dose-Response Relationship, Drug; Elec | 1973 |
The effect of diphenylhydantoin on the electroretinogram of rabbits. II. Effects of hypoxia and potassium.
Topics: Action Potentials; Animals; Cold Temperature; Electroretinography; Evoked Potentials; Extracellular | 1973 |
Seizures in newborn infants.
Topics: Birth Injuries; Brain; Calcium; Diazepam; Gluconates; Glucose; Humans; Hypocalcemia; Hypoxia; Infant | 1974 |
Antiarrhythmic drug action: selective depression of hypoxic cardiac cells.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Dose-Response Relationship, Drug; Electrophysiol | 1974 |
The role of the central nervous system in shock: the centroneurogenic etiology of the respiratory distress syndrome.
Topics: Animals; Brain; Carbon Dioxide; Cardiac Output; Central Nervous System; Cerebrovascular Circulation; | 1974 |
"Protective" action of diphenylhydantoin on canine Purkinje fibers during hypoxia.
Topics: Action Potentials; Animals; Carbon Dioxide; Coronary Vessels; Dogs; Electric Stimulation; Electrocar | 1970 |
Cardiac arrhythmias during electroshock therapy: significance, prevention, and treatment.
Topics: Acidosis, Respiratory; Aged; Arrhythmias, Cardiac; Blood Gas Analysis; Coronary Disease; Electrocard | 1970 |
[Hemodynamic changes due to diphenylhydantoin in digitalized heart patients].
Topics: Arrhythmias, Cardiac; Blood Gas Analysis; Blood Pressure; Cardiac Catheterization; Cardiac Output; C | 1970 |
Diphenylhydantoin and sodium influx.
Topics: Animals; Crustacea; Electric Stimulation; Hypoxia; Nervous System; Phenytoin; Sodium | 1970 |
Effects of phenobarbital, phenytoin, and anoxia on connective tissue of mice.
Topics: Animals; Collagen; Connective Tissue; Electrolytes; Fats; Hydroxyproline; Hypoxia; Liver; Mice; Phen | 1968 |