phenytoin has been researched along with Hypothyroidism in 49 studies
Hypothyroidism: A syndrome that results from abnormally low secretion of THYROID HORMONES from the THYROID GLAND, leading to a decrease in BASAL METABOLIC RATE. In its most severe form, there is accumulation of MUCOPOLYSACCHARIDES in the SKIN and EDEMA, known as MYXEDEMA. It may be primary or secondary due to other pituitary disease, or hypothalamic dysfunction.
| Excerpt | Relevance | Reference |
|---|---|---|
| " He had been administered phenytoin and gabapentin for the treatment of symptomatic traumatic epilepsy 8 years before." | 7.88 | Hypothyroidism induced by phenytoin and gabapentin: A Case Report. ( Ishii, K; Miyake, Z; Tamaoka, A, 2018) |
| "A 42-year-old woman who presented phenytoin intoxication induced by acute hypothyroidism was reported." | 7.68 | [A case of phenytoin intoxication induced by hypothyroidism]. ( Fujitake, J; Horii, K; Ishikawa, K; Shimbo, S; Tatsuoka, Y, 1991) |
| " He had been administered phenytoin and gabapentin for the treatment of symptomatic traumatic epilepsy 8 years before." | 3.88 | Hypothyroidism induced by phenytoin and gabapentin: A Case Report. ( Ishii, K; Miyake, Z; Tamaoka, A, 2018) |
| "The results indicated an increased risk of hypothyroidism among patients using AEDs, especially phenytoin, valproate, phenobarbital, carbamazepine, and oxcarbazepine." | 3.79 | Use of antiepileptic drugs and risk of hypothyroidism. ( Hsieh, CY; Lai, EC; Lin, SJ; Yang, YH, 2013) |
| "A 42-year-old woman who presented phenytoin intoxication induced by acute hypothyroidism was reported." | 3.68 | [A case of phenytoin intoxication induced by hypothyroidism]. ( Fujitake, J; Horii, K; Ishikawa, K; Shimbo, S; Tatsuoka, Y, 1991) |
| " We measured FT4 in a total of 325 serum samples from euthyroid patients; patients receiving replacement thyroxin; patients receiving estrogens or who were pregnant; hyperthyroid, hypothyroid, and non- thyroidally ill patients; and patients receiving salicylates, phenytoin, or heparin." | 3.67 | Estimation of free thyroxin with a new thyroxin analog and a porous-glass solid phase. ( Gilbert, SS; Shuler, SE; Witherspoon, LR, 1984) |
| "Quantitative histomorphometric analyses of iliac crest biopsy specimens were performed after tetracycline double-labeling in 41 normal individuals, 20 hyper- and 10 hypothyroid patients, 18 patients with primary hyperparathyroidism, 20 epileptic patients receiving long-term anticonvulsant therapy, and 17 patients after jejunoileal bypass for morbid obesity." | 3.66 | Trabecular bone mineralization lag time determined by tetracycline double-labeling in normal and certain pathological conditions. ( Melsen, F; Mosekilde, L, 1980) |
| "Two patients on long-term anti-epileptic treatment, one with both phenytoin and carbamazepine, the other with carbamazepine, developed clinical hypothyroidism." | 3.66 | Hypothyroidism induced by anti-epileptic therapy. ( Aanderud, S; Strandjord, RE, 1980) |
| "The metabolism of phenytoin was studied in 9 hyperthyroid and 7 hypothyroid patients before and after treatment with either antithyroid drugs or 1-thyroxine." | 3.66 | Unaltered metabolism of phenytoin in thyroid disorders. ( Kampmann, JP; Lumholtz, BI; Mølholm Hansen, J; Siersbaek-Nielsen, K; Skovsted, L, 1978) |
| "The prevalence of unrecognized primary hypothyroidism and hyperthyroidism was 5·2% and 2·8%, respectively." | 1.37 | Thyroid status in a large cohort of patients with mental retardation: the TOP-R (Thyroid Origin of Psychomotor Retardation) study. ( de Rijke, YB; van Toor, H; Visser, TJ; Visser, WE, 2011) |
| "Phenytoin levels were measured and found to be grossly elevated at 170 mmol/L." | 1.35 | Phenytoin toxicity and thyroid dysfunction. ( Betteridge, T; Fink, J, 2009) |
| "Phenytoin is a widely used anticonvulsant which has a relatively narrow therapeutic range of serum concentrations, 40-80 mmol/l (10-20 mg/l)." | 1.29 | Hypothyroxinemia and phenytoin toxicity: a vicious circle. ( Sarich, TC; Wright, JM, 1996) |
| "Hyperthyroidism was found in 3/402 (0." | 1.26 | The prevalence of thyroid dysfunction in mentally handicapped in-patients. ( Cameron, J; Goonetilleke, AS; Hughes, VC, 1982) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 41 (83.67) | 18.7374 |
| 1990's | 4 (8.16) | 18.2507 |
| 2000's | 1 (2.04) | 29.6817 |
| 2010's | 3 (6.12) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Miyake, Z | 1 |
| Ishii, K | 1 |
| Tamaoka, A | 1 |
| Lai, EC | 1 |
| Yang, YH | 1 |
| Lin, SJ | 1 |
| Hsieh, CY | 1 |
| Betteridge, T | 1 |
| Fink, J | 1 |
| Visser, WE | 1 |
| de Rijke, YB | 1 |
| van Toor, H | 1 |
| Visser, TJ | 1 |
| MURPHY, BE | 2 |
| PATTEE, CJ | 2 |
| Hughes, VC | 1 |
| Cameron, J | 1 |
| Goonetilleke, AS | 1 |
| Postellon, DC | 1 |
| Witherspoon, LR | 1 |
| Shuler, SE | 1 |
| Gilbert, SS | 1 |
| Blackshear, JL | 1 |
| Schultz, AL | 1 |
| Napier, JS | 1 |
| Stuart, DD | 1 |
| Gambert, SR | 1 |
| Garthwaite, TL | 1 |
| Melsen, F | 1 |
| Mosekilde, L | 1 |
| Aanderud, S | 1 |
| Strandjord, RE | 1 |
| Schwarz, U | 1 |
| Lämmle, B | 1 |
| Six, P | 1 |
| Haas, HG | 1 |
| Tiihonen, M | 1 |
| Liewendahl, K | 2 |
| Waltimo, O | 1 |
| Ojala, M | 1 |
| Välimäki, M | 1 |
| Gonzalez, IG | 1 |
| Martin Luquero, M | 1 |
| Marcos Martinez, L | 1 |
| Gargallo Fernandez, MA | 1 |
| Sarich, TC | 1 |
| Wright, JM | 1 |
| Mølholm Hansen, J | 1 |
| Skovsted, L | 1 |
| Kampmann, JP | 1 |
| Lumholtz, BI | 1 |
| Siersbaek-Nielsen, K | 3 |
| Rabl, W | 1 |
| Windorfer, A | 1 |
| Rosengård, S | 1 |
| Lamberg, BA | 1 |
| Sollberg, G | 1 |
| Klein, HD | 1 |
| Sollberg, S | 1 |
| Jiang, NS | 1 |
| Tue, KA | 1 |
| Nicholson, G | 1 |
| Liebling, LI | 1 |
| Hall, RA | 1 |
| Hauteville, A | 1 |
| Horii, K | 1 |
| Fujitake, J | 1 |
| Tatsuoka, Y | 1 |
| Ishikawa, K | 1 |
| Shimbo, S | 1 |
| Gilsanz Peral, A | 1 |
| Costa Talens, P | 1 |
| Gómez Balaguer, M | 1 |
| Finnerty, JP | 1 |
| Kushnir, M | 1 |
| Weinstein, R | 1 |
| Landau, B | 1 |
| Shavit, G | 1 |
| Bechar, M | 1 |
| Gadoth, N | 1 |
| Surks, MI | 1 |
| Faber, J | 1 |
| Lumholtz, IB | 1 |
| Kirkegaard, C | 1 |
| Poulsen, S | 1 |
| Jørgensen, PH | 1 |
| Friis, T | 2 |
| Hamburger, JI | 1 |
| Meier, DA | 1 |
| Horiguchi, T | 1 |
| Nusynowitz, ML | 1 |
| Strader, WJ | 1 |
| Chan, V | 1 |
| Williams, EM | 1 |
| Gold, A | 1 |
| Kolendorf, K | 1 |
| Hansen, MJ | 1 |
| Reynolds, EH | 1 |
| Parker, WA | 1 |
| Gumnit, RJ | 1 |
| Gharib, H | 1 |
| Ryan, RJ | 1 |
| Mayberry, WE | 1 |
| Sakurada, T | 2 |
| Yamaguchi, T | 2 |
| Yamamoto, M | 2 |
| Tayama, S | 1 |
| Demura, H | 1 |
| Giménez-Roldán, S | 1 |
| Esteban, A | 1 |
| Brookeman, VA | 1 |
| Saito, S | 1 |
| Demura, R | 1 |
| Wu, NF | 1 |
| Kushnick, T | 1 |
| Sparagana, M | 1 |
| Phillips, G | 1 |
| Kucera, L | 1 |
| Zaninovich, AA | 1 |
| Farach, H | 1 |
| Ezrin, C | 1 |
| Volpé, R | 1 |
| Jubiz, W | 2 |
| Meikle, AW | 1 |
| Tyler, FH | 1 |
| West, CD | 2 |
| Bigler, AH | 1 |
| Kumagai, LF | 1 |
| Fulop, M | 1 |
| Widrow, DR | 1 |
| Colmers, RA | 1 |
| Epstein, EJ | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Effects of Thyroid Hormone on Cytochrome P450 and P-Glycoprotein Activity in Thyroid Cancer Patients[NCT00080574] | Phase 2 | 20 participants | Interventional | 2004-04-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for phenytoin and Hypothyroidism
| Article | Year |
|---|---|
Diagnosis and treatment of congenital hypothyroidism.
Topics: Cholestyramine Resin; Congenital Hypothyroidism; Drug Interactions; Female; Humans; Hypothyroidism; | 1983 |
Triiodothyronine (T3) radioimmunoassay. A critical evaluation.
Topics: Benzoates; Binding Sites; Cross Reactions; Diet; Ethylmercury Compounds; Evaluation Studies as Topic | 1972 |
2 trials available for phenytoin and Hypothyroidism
| Article | Year |
|---|---|
Thyroid status of patients receiving long-term anticonvulsant therapy assessed by peripheral parameters: a placebo-controlled thyroxine therapy trial.
Topics: Adult; Age Distribution; Anticonvulsants; Carbamazepine; Comorbidity; Cross-Over Studies; Double-Bli | 1995 |
Serum thyroxine by competitive protein binding analysis: clinical, statistical and comparative evaluation.
Topics: Blood Chemical Analysis; Blood Proteins; Chemistry, Clinical; Chromatography, Ion Exchange; Clinical | 1969 |
45 other studies available for phenytoin and Hypothyroidism
| Article | Year |
|---|---|
Hypothyroidism induced by phenytoin and gabapentin: A Case Report.
Topics: Aged; Amines; Anticonvulsants; Cyclohexanecarboxylic Acids; Epilepsy; Gabapentin; gamma-Aminobutyric | 2018 |
Use of antiepileptic drugs and risk of hypothyroidism.
Topics: Anticonvulsants; Databases, Factual; Epilepsy; Humans; Hypothyroidism; Phenytoin; Risk Factors; Taiw | 2013 |
Phenytoin toxicity and thyroid dysfunction.
Topics: Anticonvulsants; Epilepsy; Female; Follow-Up Studies; Humans; Hypothyroidism; Middle Aged; Phenytoin | 2009 |
Thyroid status in a large cohort of patients with mental retardation: the TOP-R (Thyroid Origin of Psychomotor Retardation) study.
Topics: Adult; Aged; Anticonvulsants; Carbamazepine; Cohort Studies; Cross-Sectional Studies; Drug Therapy, | 2011 |
DETERMINATION OF THYROXINE UTILIZING THE PROPERTY OF PROTEIN-BINDING.
Topics: Aspirin; Bilirubin; Blood Chemical Analysis; Blood Proteins; Cholesterol; Glucose; Heparin; Hyperthy | 1964 |
The prevalence of thyroid dysfunction in mentally handicapped in-patients.
Topics: Adolescent; Adult; Aged; Child; Child, Preschool; Cross-Sectional Studies; Down Syndrome; Female; Hu | 1982 |
Estimation of free thyroxin with a new thyroxin analog and a porous-glass solid phase.
Topics: Female; Glass; Heparin; Humans; Hyperthyroidism; Hypothyroidism; Male; Methods; Phenytoin; Pregnancy | 1984 |
Thyroxine replacement requirements in hypothyroid patients receiving phenytoin.
Topics: Adult; Drug Administration Schedule; Female; Humans; Hypothyroidism; Phenytoin; Recurrence; Thyrotro | 1983 |
The effect of diphenylhydantoin on basal and stimulated thyroid stimulating hormone (TSH) and prolactin secretion in euthyroid and hypothyroid rats.
Topics: Animals; Hypothyroidism; Male; Phenytoin; Prolactin; Rats; Thyrotropin; Thyrotropin-Releasing Hormon | 1980 |
Trabecular bone mineralization lag time determined by tetracycline double-labeling in normal and certain pathological conditions.
Topics: Adult; Aged; Biopsy; Bone and Bones; Bone Diseases; Female; Humans; Hyperparathyroidism; Hyperthyroi | 1980 |
Hypothyroidism induced by anti-epileptic therapy.
Topics: Aged; Carbamazepine; Female; Humans; Hypothyroidism; Middle Aged; Phenytoin | 1980 |
Polyendocrine deficiency syndrome. Occurrence in a patient with depressed IgA titers receiving phenytoin.
Topics: Addison Disease; Adult; Amenorrhea; Autoimmune Diseases; Endocrine System Diseases; Female; Humans; | 1980 |
[Study of the influence of anticonvulsant treatment on thyroid function].
Topics: Adolescent; Adult; Aged; Anticonvulsants; Carbamazepine; Child; Enzyme-Linked Immunosorbent Assay; E | 1995 |
Hypothyroxinemia and phenytoin toxicity: a vicious circle.
Topics: Anticonvulsants; Enzyme Induction; Female; Humans; Hypothyroidism; Liver; Middle Aged; Phenytoin; Th | 1996 |
Unaltered metabolism of phenytoin in thyroid disorders.
Topics: Adult; Aged; Antipyrine; Female; Half-Life; Humans; Hyperthyroidism; Hypothyroidism; Male; Middle Ag | 1978 |
[Myopathia and hypothyroidism caused by diphenylhydantoin].
Topics: Humans; Hypothyroidism; Muscular Diseases; Phenytoin | 1977 |
Nuclear binding of triiodothyronine and thyroxine in lymphocytes from subjects with hyperthyroidism, hypothyroidism and resistance to thyroid hormones.
Topics: Adult; Binding, Competitive; Cell Nucleus; Cells, Cultured; Female; Humans; Hyperthyroidism; Hypothy | 1978 |
[Myopathy and hypothyreosis caused by diphenylhydantoin].
Topics: Adult; Humans; Hypothyroidism; Male; Muscular Diseases; Phenytoin; Time Factors | 1977 |
Determination of free thyroxine in serum by radioimmunoassay.
Topics: Cross Reactions; Humans; Hyperthyroidism; Hypothyroidism; Microchemistry; Phenytoin; Radioimmunoassa | 1977 |
Thyroid dysfunction in female psychiatric patients.
Topics: Adult; Age Factors; Aged; Aspirin; Female; Humans; Hypothyroidism; Lithium; Mental Disorders; Middle | 1976 |
[Hydantoin induced gingival hyperplasia].
Topics: Cholesterol; Gingiva; Gingival Hyperplasia; Humans; Hypothyroidism; Lipids; Phenytoin; Thyroid Funct | 1975 |
[A case of phenytoin intoxication induced by hypothyroidism].
Topics: Acute Disease; Adult; Cerebellar Ataxia; Female; Humans; Hypothyroidism; Phenytoin; Thyroid Gland; T | 1991 |
[Diphenylhydantoin and primary hypothyroidism].
Topics: Epilepsy; Female; Humans; Hypothyroidism; Middle Aged; Phenytoin | 1986 |
Hypothyroidism and phenytoin intoxication.
Topics: Aged; Humans; Hypothyroidism; Phenytoin; Thyrotropin-Releasing Hormone | 1985 |
Hypothyroidism and phenytoin intoxication.
Topics: Aged; Epilepsy; Female; Humans; Hypothyroidism; Phenytoin; Thyrotropin; Thyroxine | 1985 |
Hypothyroidism and phenytoin.
Topics: Humans; Hypothyroidism; Phenytoin; Thyroid Hormones | 1985 |
The effects of phenytoin (diphenylhydantoin) on the extrathyroidal turnover of thyroxine, 3,5,3'-triiodothyronine, 3,3',5'-triiodothyronine, and 3',5'-diiodothyronine in man.
Topics: Aged; Animals; Biotransformation; Diiodothyronines; Female; Humans; Hypothyroidism; In Vitro Techniq | 1985 |
How to use modern thyroid function tests.
Topics: Androgens; Antithyroid Agents; Drug Therapy; Estrogens; Humans; Hyperthyroidism; Hypothyroidism; Iod | 1971 |
[Clinical study on determination of blood thyroid hormone levels using the protein binding test--free thyroxine index in young children].
Topics: Age Factors; Androgens; Antithyroid Agents; Child; Child, Preschool; Down Syndrome; Dwarfism, Pituit | 1971 |
A new estimate of the thyroxine binding globulin capacity.
Topics: Binding, Competitive; Chromatography; Contraceptives, Oral; Female; Humans; Hyperthyroidism; Hypothy | 1972 |
The assay of urinary thyroid hormones for assessing thyroid function.
Topics: Adult; Circadian Rhythm; Diagnosis, Differential; Estrogens; Female; Humans; Hyperthyroidism; Hypoth | 1974 |
Cellular basis of cardiac dysrhythmias.
Topics: Action Potentials; Arrhythmias, Cardiac; Benzofurans; Bretylium Compounds; Cell Membrane Permeabilit | 1974 |
Clinical evaluation of a new method for the determination of serum thyroxine.
Topics: Adult; Blood; Cholesterol; Estrogens; Female; Humans; Hyperthyroidism; Hypoproteinemia; Hypothyroidi | 1966 |
Evaluation of thyroid status with "effective thyroxine ratio" (E.T.R.).
Topics: Adolescent; Adult; Aged; Aspirin; Depression, Chemical; Estrogens; Evaluation Studies as Topic; Fema | 1974 |
Iatrogenic disorders in epilepsy.
Topics: Adrenal Insufficiency; Anemia, Macrocytic; Animals; Anticonvulsants; Cats; Cerebellar Diseases; Drug | 1970 |
Diphenylhydantoin toxicity: dose-dependent blood dyscrasia.
Topics: Adult; Amenorrhea; Dose-Response Relationship, Drug; Epilepsy; Female; Humans; Hypothermia; Hypothyr | 1974 |
[Radioimmunoassay of triiodothyronine].
Topics: Congenital Hypothyroidism; Dinitrophenols; Humans; Hyperthyroidism; Hypothyroidism; Iodine Isotopes; | 1972 |
Orbicularis oculi "myotonia" in hypothyroid myopathy.
Topics: Cold Temperature; Diazepam; Electromyography; Humans; Hypothyroidism; Male; Middle Aged; Muscle Cont | 1973 |
Non-Gaussian distribution of serum thyroxine levels for euthyroid population.
Topics: Adolescent; Adult; Aged; Androgens; Binding, Competitive; Child; Child, Preschool; Estrogens; Female | 1973 |
Radioimmunoassay of triiodothyronine.
Topics: Animals; Cross Reactions; Dinitrophenols; Humans; Hyperthyroidism; Hypothyroidism; Imidazoles; Immun | 1973 |
The Beckwith-Wiedemann syndrome. The exomphalos-macroglossia-gigantism syndrome.
Topics: Abnormalities, Multiple; Blood Glucose; Brain Damage, Chronic; Congenital Hypothyroidism; Diagnosis, | 1974 |
Lack of significant binding of L-triiodothyronine by thyroxine-binding globulin in vivo as demonstrated by acute disappearance of 131-I-labeled triiodothyronine.
Topics: Adolescent; Adult; Aged; Epilepsy; Estrogens; Female; Hepatitis; Humans; Hyperthyroidism; Hypothyroi | 1966 |
Serum thyroxine specific activity (T4SA) in the diagnosis of thyroid dysfunction.
Topics: Blood Protein Disorders; Chromatography, Paper; Estrogens; Humans; Hyperthyroidism; Hypothyroidism; | 1969 |
Estimation of thyroxine production rates in non-steady states.
Topics: Contraceptives, Oral; Female; Humans; Hyperthyroidism; Hypothyroidism; Injections, Intravenous; Iodi | 1972 |
Possible diphenylhydantoin-induced arrhythmia in hypothyroidism.
Topics: Hypothyroidism; Phenytoin; Rheumatic Heart Disease; Tachycardia | 1966 |