Page last updated: 2024-10-21

phenytoin and Hypotension

phenytoin has been researched along with Hypotension in 36 studies

Hypotension: Abnormally low BLOOD PRESSURE that can result in inadequate blood flow to the brain and other vital organs. Common symptom is DIZZINESS but greater negative impacts on the body occur when there is prolonged depravation of oxygen and nutrients.

Research Excerpts

ExcerptRelevanceReference
"We compared propofol with high-dose barbiturates in the treatment of refractory status epilepticus (RSE) and propose a protocol for the administration of propofol in RSE in adults, correlating propofol's effect with plasma levels."9.08Treatment of refractory status epilepticus with propofol: clinical and pharmacokinetic findings. ( Dulaney, E; Kramer, TH; O'Meeghan, R; Raps, EC; Skaar, DJ; Stecker, MM, 1998)
" When seizures developed, intravenous phenytoin sodium therapy was begun."7.66Dopamine-phenytoin interaction. A cause of hypotension in the critically ill. ( Bivins, BA; Blouin, R; Bustrack, J; Griffen, WO; Rapp, RP, 1978)
" Various clinical and demographic parameters were analysed, including comorbidities, drug history, seizure aetiology and type, incidence of hypotension/cardiac arrhythmia and the dosing data (ie the total dose, concentration and FOS IV infusion rate)."5.46Incidence and risk factors of hypotension after intravenous fosphenytoin administration. ( Hwang, IG; Kim, DW; Kim, HK; Koh, IS, 2017)
"In a randomized, blinded, adaptive trial, we compared the efficacy and safety of three intravenous anticonvulsive agents - levetiracetam, fosphenytoin, and valproate - in children and adults with convulsive status epilepticus that was unresponsive to treatment with benzodiazepines."5.30Randomized Trial of Three Anticonvulsant Medications for Status Epilepticus. ( Barsan, W; Chamberlain, JM; Cloyd, J; Cock, H; Connor, JT; Conwit, R; Elm, J; Fountain, N; Kapur, J; Lowenstein, D; Meinzer, C; Shinnar, S; Silbergleit, R, 2019)
" In this prospective, descriptive study four dosage regimens were investigated in 104 patients."5.28Clinical experience with phenytoin prophylaxis in severe preeclampsia. ( Lange, IR; Naugler, MA; Ryan, G, 1989)
"We compared propofol with high-dose barbiturates in the treatment of refractory status epilepticus (RSE) and propose a protocol for the administration of propofol in RSE in adults, correlating propofol's effect with plasma levels."5.08Treatment of refractory status epilepticus with propofol: clinical and pharmacokinetic findings. ( Dulaney, E; Kramer, TH; O'Meeghan, R; Raps, EC; Skaar, DJ; Stecker, MM, 1998)
"The antiarrhythmic effects of procainamide and phenytoin were studied in 81 patients admitted to the coronary care unit at the University Hospital in Linköping because of a suspected or proven diagnosis of acute myocardial infarction, and who developed ventricular arrhyhmias, requiring treatment, during the first 8 hours in hospital."5.04Procainamide and phenytoin. Comparative study of their antiarrhythmic effects at apparent therapeutic plasma levels. ( Karlsson, E, 1975)
"To study the incidence and extent of the occasionally noted hypotension after intravenous (IV) infusions of fosphenytoin (FOS) and levetiracetam (LEV) in patients presenting with acute cerebral symptoms."3.75Blood pressure changes after intravenous fosphenytoin and levetiracetam in patients with acute cerebral symptoms. ( Farooq, MU; Kassab, MY; Lobeck, IN; Majid, A; Xie, Y, 2009)
"Colchicine poisoning is an uncommon, but potentially life-threatening, toxicologic emergency."3.74Acute colchicine intoxication in a child: a case report. ( Biçer, S; Ctak, A; Karaböcüoğlu, M; Soysal, DD; Uçsel, R; Uzel, N, 2007)
" When seizures developed, intravenous phenytoin sodium therapy was begun."3.66Dopamine-phenytoin interaction. A cause of hypotension in the critically ill. ( Bivins, BA; Blouin, R; Bustrack, J; Griffen, WO; Rapp, RP, 1978)
"All phenytoin was administered intravenously, and fosphenytoin was given intravenously or intramuscularly (physician preference)."2.70Randomized evaluation of adverse events and length-of-stay with routine emergency department use of phenytoin or fosphenytoin. ( Clements, EA; Cochran, MS; Coplin, WM; O'Neil, BJ; Rebuck, JA; Rhoney, DH, 2002)
"Perioperative seizure prophylaxis with antiepileptic drugs (AED) has been advocated in patients undergoing supratentorial craniotomy."1.48The risk of hypotension and seizures in patients receiving prophylactic anti-epileptic drugs for supratentorial craniotomy. ( Brawanski, A; Höhne, J; Lange, M; Ott, C; Schebesch, KM, 2018)
" Various clinical and demographic parameters were analysed, including comorbidities, drug history, seizure aetiology and type, incidence of hypotension/cardiac arrhythmia and the dosing data (ie the total dose, concentration and FOS IV infusion rate)."1.46Incidence and risk factors of hypotension after intravenous fosphenytoin administration. ( Hwang, IG; Kim, DW; Kim, HK; Koh, IS, 2017)
" This investigation sought to elucidate both the incidence and nature of acute intravenous phenytoin toxicity in emergency department patients, and to identify any demographic, clinical, or dosing associations with toxicity, by analyzing a retrospective case series over 3 years in a municipal teaching hospital."1.29Association of intravenous phenytoin toxicity with demographic, clinical, and dosing parameters. ( Binder, L; Cuetter, A; Parker, D; Trujillo, J, 1996)
" In this prospective, descriptive study four dosage regimens were investigated in 104 patients."1.28Clinical experience with phenytoin prophylaxis in severe preeclampsia. ( Lange, IR; Naugler, MA; Ryan, G, 1989)
"Phenytoin has been proposed as a prophylaxis and treatment of these dysrhythmias, since it is thought to improve conduction in this setting."1.27Phenytoin prophylaxis of cardiotoxicity in experimental amitriptyline poisoning. ( Callaham, M; Pentel, P; Schumaker, H, 1988)
"Phenytoin was administered intravenously in large doses (mean = 16."1.26Intravenous phenytoin: clinical and pharmacokinetic aspects. ( Anderson, CB; Cranford, RE; Kostick, B; Leppik, IE; Patrick, B, 1978)

Research

Studies (36)

TimeframeStudies, this research(%)All Research%
pre-199025 (69.44)18.7374
1990's3 (8.33)18.2507
2000's5 (13.89)29.6817
2010's3 (8.33)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Kapur, J1
Elm, J1
Chamberlain, JM1
Barsan, W1
Cloyd, J1
Lowenstein, D1
Shinnar, S1
Conwit, R1
Meinzer, C1
Cock, H1
Fountain, N1
Connor, JT1
Silbergleit, R1
Kim, HK1
Hwang, IG1
Koh, IS1
Kim, DW1
Höhne, J1
Schebesch, KM1
Ott, C1
Brawanski, A1
Lange, M1
Kassab, MY1
Lobeck, IN1
Majid, A1
Xie, Y1
Farooq, MU1
Coplin, WM1
Rhoney, DH1
Rebuck, JA1
Clements, EA1
Cochran, MS1
O'Neil, BJ1
Appleton, RE1
Gill, A1
KONG, Y1
HEYMAN, A1
ENTMAN, ML1
MCINTOSH, HD1
CONN, RD1
Hobgood, C1
Hevia, A1
Hinchey, P1
Biçer, S1
Soysal, DD1
Ctak, A1
Uçsel, R1
Karaböcüoğlu, M1
Uzel, N1
Drake, CE1
Tibbs, PA1
Bivins, BA2
Rapp, RP2
Young, AB1
Griffen, WO2
Haack, DG1
Binder, L1
Trujillo, J1
Parker, D1
Cuetter, A1
Stecker, MM1
Kramer, TH1
Raps, EC1
O'Meeghan, R1
Dulaney, E1
Skaar, DJ1
Boldyrev, AI1
Fleĭs, EP1
Vaĭntrub, MIa1
Diehl, LW1
Cranford, RE1
Leppik, IE1
Patrick, B1
Anderson, CB1
Kostick, B1
Blouin, R1
Bustrack, J1
Karlsson, E1
Bosl, R1
Shideman, JR1
Meyer, RM1
Buselmeier, TJ1
von Hartitzsch, B1
Kjellstrand, CM1
Isenstein, D1
Nasraway, SA1
Ryan, G1
Lange, IR1
Naugler, MA1
Walsh, DM1
Callaham, M1
Schumaker, H1
Pentel, P1
Glogner, P1
Golochevskaia, VS1
Resnekov, L1
Ranney, BK1
Fuhrman, GJ1
Fuhrman, FA1
Raynaud, R1
Brochier, M1
Fauchier, JP1
Raynaud, P1
Binder, C1
Wimmer, M1
Patton, RD1
Moccetti, T1
Lichtlen, P1
Casaccia, M1
Halter, J1
Mohr, P1
Porciello, PI1
Zanini, S1
Poppi, A1
Laursen, AB1
Mixter, CG1
Moran, JM1
Austen, WG1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Multicenter, Randomized, Blinded, Comparative Effectiveness Study of Fosphenytoin, Valproic Acid, or Levetiracetam in the Emergency Department Treatment of Patients With Benzodiazepine-refractory Status Epilepticus.[NCT01960075]Phase 3478 participants (Actual)Interventional2015-10-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Length of Hospital Stay

Length of hospital stay in days (NCT01960075)
Timeframe: length of hospital stay

Interventiondays (Median)
Fosphenytoin (FOS)3
Valproic Acid3
Levetiracetam3

Length of ICU Stay

Length of stay is determined by the number of calendar days after the day of ED arrival until hospital discharge or subject end-of-study. (NCT01960075)
Timeframe: number of calendar days after the day of ED arrival until hospital discharge or subject end-of-study

Interventiondays (Median)
Fosphenytoin (FOS)1
Valproic Acid1
Levetiracetam1

Minutes From Start of Trial Drug Infusion to Termination of Seizures for Patients With Treatment Success

The time to termination of seizures is the interval from the start of study drug infusion to cessation of clinically apparent seizure in those who meet the primary outcome. (NCT01960075)
Timeframe: start of drug infusion to seizure cessation

Interventionminutes (Median)
Fosphenytoin (FOS)11.7
Valproic Acid7.0
Levetiracetam10.5

Number of Participants With Admission to Intensive Care Unit

ICU admission is recorded as occurring only if the ICU is the initial inpatient unit for the patient. (NCT01960075)
Timeframe: Admission to intensive care unit after start of study drug infusion, where the ICU is the initial inpatient unit for the patient

InterventionParticipants (Count of Participants)
Fosphenytoin (FOS)70
Valproic Acid71
Levetiracetam87

Number of Participants With Clinical Cessation of Status Epilepticus - Adjudicated Outcomes Analysis

Determined by the absence of clinically apparent seizures and improving consciousness at 1 hour without other anticonvulsant medications. The Adjudicated outcomes analysis is different from Outcome measure 1 because a central clinical phenomenology core of four neurologists adjudicated from the medical records the time to seizure cessation, the time in status epilepticus before trial-drug initiation, and the cause of the seizure. For each enrollment, two neurologists from this core group conducted independent initial reviews and then determined a consensus or consulted a third adjudicator, as needed. Adjudicators were unaware of the treatment assignments and made determinations by medical record review. (NCT01960075)
Timeframe: Within 60 minutes after the start of study drug infusion

InterventionParticipants (Count of Participants)
Fosphenytoin (FOS)57
Valproic Acid60
Levetiracetam67

Number of Participants With Clinical Cessation of Status Epilepticus - Intention to Treat

Determined by the absence of clinically apparent seizures and improving consciousness at 1 hour without other anticonvulsant medications. Intention to treat (NCT01960075)
Timeframe: Within 60 minutes after the start of study drug infusion

InterventionParticipants (Count of Participants)
Fosphenytoin (FOS)53
Valproic Acid56
Levetiracetam68

Number of Participants With Clinical Cessation of Status Epilepticus - Per-protocol Analysis

Determined by the absence of clinically apparent seizures and improving consciousness at 1 hour without other anticonvulsant medications. Per-protocol analysis (NCT01960075)
Timeframe: Within 60 minutes after the start of study drug infusion

InterventionParticipants (Count of Participants)
Fosphenytoin (FOS)37
Valproic Acid43
Levetiracetam51

Number of Participants With Safety Outcome: Acute Anaphylaxis

Acute anaphylaxis is defined as a clinical presentation consistent with life threatening allergic reaction occurring within 6 hours of the start of study drug infusions and manifested as urticaria in combination with either (1) a systolic blood pressure of < 90 mmHg sustained for greater than 5 minutes, or (2) objective evidence of airway obstruction, and for which the patient was treated with antihistamines and/or steroids. (NCT01960075)
Timeframe: within 6 hours of the start of study drug infusions

InterventionParticipants (Count of Participants)
Fosphenytoin (FOS)0
Valproic Acid0
Levetiracetam0

Number of Participants With Safety Outcome: Acute Respiratory Depression

Respiratory depression is defined as impairment of ventilation or oxygenation necessitating definitive endotracheal intubation and mechanical ventilation. It is distinct from intubations performed only for airway protection in those with decreased levels of consciousness. It does not include those getting only supraglottic airways or transient bag-valve-mask support. (NCT01960075)
Timeframe: 24 hours

InterventionParticipants (Count of Participants)
Fosphenytoin (FOS)16
Valproic Acid10
Levetiracetam12

Number of Participants With Safety Outcome: Acute Seizure Recurrence

acute seizure recurrence 60 minutes to 12 hours after start of study drug infusion (NCT01960075)
Timeframe: 60 minutes to 12 hours after start of study drug infusion

InterventionParticipants (Count of Participants)
Fosphenytoin (FOS)14
Valproic Acid14
Levetiracetam16

Number of Participants With Safety Outcome: Death

Safety outcome: Death (NCT01960075)
Timeframe: 30 days

InterventionParticipants (Count of Participants)
Fosphenytoin (FOS)3
Valproic Acid2
Levetiracetam7

Number of Participants With Safety Outcome: Endotracheal Intubation

Endotracheal intubation within 60 minutes of start of study drug infusion (NCT01960075)
Timeframe: within 60 minutes of start of study drug infusion

InterventionParticipants (Count of Participants)
Fosphenytoin (FOS)33
Valproic Acid21
Levetiracetam30

Number of Participants With Safety Outcome: Hepatic Transaminase or Ammonia Elevations

Safety outcome: Hepatic transaminase or ammonia elevations (NCT01960075)
Timeframe: 24 hours

InterventionParticipants (Count of Participants)
Fosphenytoin (FOS)0
Valproic Acid1
Levetiracetam1

Number of Participants With Safety Outcome: Life Threatening Hypotension

Life-threatening hypotension within 60 minutes of the start of study drug infusion (NCT01960075)
Timeframe: within 60 minutes of the start of study drug infusion

InterventionParticipants (Count of Participants)
Fosphenytoin (FOS)4
Valproic Acid2
Levetiracetam1

Number of Participants With Safety Outcome: Life-threatening Cardiac Arrhythmia

Life-threatening cardiac arrhythmia within 60 minutes of the start of study drug infusion (NCT01960075)
Timeframe: within 60 minutes of the start of study drug infusion

InterventionParticipants (Count of Participants)
Fosphenytoin (FOS)0
Valproic Acid0
Levetiracetam1

Number of Participants With Safety Outcome: Purple Glove Syndrome

Purple glove syndrome is defined as the presence of all three of the findings of the objective edema: discoloration, and pain in the distal extremity in which study drug was administered, with or without known extravasation, and for which there is no other evident etiology. (NCT01960075)
Timeframe: 24 hours

InterventionParticipants (Count of Participants)
Fosphenytoin (FOS)0
Valproic Acid0
Levetiracetam0

Number of Participants With Seizure Cessation Within 20 Minutes for Patients With Treatment Success

Number of participants with seizure cessation within 20 minutes of study drug initiation for patients with treatment success. This outcome measure was only reported in the Supplementary materials to the Primary Paper. (NCT01960075)
Timeframe: within 20 minutes

InterventionParticipants (Count of Participants)
Fosphenytoin (FOS)43
Valproic Acid43
Levetiracetam53

Reviews

3 reviews available for phenytoin and Hypotension

ArticleYear
[Side effects of anti-arrhythmic agents].
    Klinicheskaia meditsina, 1971, Volume: 49, Issue:10

    Topics: 1-Propanol; Adrenal Cortex Hormones; Agranulocytosis; Anorexia Nervosa; Anti-Arrhythmia Agents; Anti

1971
Cardiac arrhythmias. 6. Present status of electroversion in the management of cardiac dysrhythmias.
    Circulation, 1973, Volume: 47, Issue:6

    Topics: Anticoagulants; Arrhythmias, Cardiac; Atrial Flutter; Cardiomegaly; Digitalis Glycosides; Electric C

1973
Management of arrhythmias in acute myocardial infarction.
    American family physician, 1971, Volume: 4, Issue:1

    Topics: Acid-Base Equilibrium; Adams-Stokes Syndrome; Arrhythmias, Cardiac; Atropine; Bradycardia; Cardiac O

1971

Trials

4 trials available for phenytoin and Hypotension

ArticleYear
Randomized Trial of Three Anticonvulsant Medications for Status Epilepticus.
    The New England journal of medicine, 2019, 11-28, Volume: 381, Issue:22

    Topics: Adolescent; Adult; Anticonvulsants; Benzodiazepines; Child; Child, Preschool; Double-Blind Method; D

2019
Randomized evaluation of adverse events and length-of-stay with routine emergency department use of phenytoin or fosphenytoin.
    Neurological research, 2002, Volume: 24, Issue:8

    Topics: Adult; Aged; Aged, 80 and over; Drug Administration Schedule; Drug Therapy, Combination; Emergency S

2002
Treatment of refractory status epilepticus with propofol: clinical and pharmacokinetic findings.
    Epilepsia, 1998, Volume: 39, Issue:1

    Topics: Adult; Aged; Barbiturates; Clinical Protocols; Drug Administration Schedule; Drug Therapy, Combinati

1998
Procainamide and phenytoin. Comparative study of their antiarrhythmic effects at apparent therapeutic plasma levels.
    British heart journal, 1975, Volume: 37, Issue:7

    Topics: Acute Disease; Adult; Aged; Animals; Arrhythmias, Cardiac; Clinical Trials as Topic; Dogs; Electroca

1975

Other Studies

29 other studies available for phenytoin and Hypotension

ArticleYear
Incidence and risk factors of hypotension after intravenous fosphenytoin administration.
    Journal of clinical pharmacy and therapeutics, 2017, Volume: 42, Issue:5

    Topics: Adult; Age Factors; Aged; Aged, 80 and over; Anticonvulsants; Blood Pressure; Female; Humans; Hypote

2017
The risk of hypotension and seizures in patients receiving prophylactic anti-epileptic drugs for supratentorial craniotomy.
    Journal of neurosurgical sciences, 2018, Volume: 62, Issue:4

    Topics: Acetamides; Adult; Anticonvulsants; Blood Pressure; Craniotomy; Female; Humans; Hypotension; Lacosam

2018
Blood pressure changes after intravenous fosphenytoin and levetiracetam in patients with acute cerebral symptoms.
    Epilepsy research, 2009, Volume: 87, Issue:2-3

    Topics: Adult; Aged; Aged, 80 and over; Blood Pressure; Chi-Square Distribution; Female; Humans; Hypotension

2009
Adverse events associated with intravenous phenytoin in children: a prospective study.
    Seizure, 2003, Volume: 12, Issue:6

    Topics: Adolescent; Anticonvulsants; Arrhythmia, Sinus; Child; Child, Preschool; Epilepsy; Extravasation of

2003
GLOSSOPHARYNGEAL NEURALGIA ASSOCIATED WITH BRADYCARDIA, SYNCOPE, AND SEIZURES.
    Circulation, 1964, Volume: 30

    Topics: Atropine; Bradycardia; Drug Therapy; Electrocardiography; Geriatrics; Glossopharyngeal Nerve; Glosso

1964
DIPHENYLHYDANTOIN SODIUM IN CARDIAC ARRHYTHMIAS.
    The New England journal of medicine, 1965, Feb-11, Volume: 272

    Topics: Arrhythmias, Cardiac; Atrial Fibrillation; Atrial Flutter; Bradycardia; Digitalis Glycosides; Drug T

1965
Profiles in patient safety: when an error occurs.
    Academic emergency medicine : official journal of the Society for Academic Emergency Medicine, 2004, Volume: 11, Issue:7

    Topics: Acetates; Aged; Amines; Analgesics; Anticonvulsants; Cyclohexanecarboxylic Acids; Diabetic Neuropath

2004
Acute colchicine intoxication in a child: a case report.
    Pediatric emergency care, 2007, Volume: 23, Issue:5

    Topics: Acute Disease; Alopecia; Ataxia; Blood Transfusion; Case Management; Child, Preschool; Colchicine; C

2007
Cardiac arrhythmias and sodium diphenylhydantoin--an appraisal.
    JAMA, 1967, Jul-10, Volume: 201, Issue:2

    Topics: Arrhythmias, Cardiac; Heart Block; Hemodynamics; Humans; Hypotension; Injections, Intravenous; Pheny

1967
Cardiac drug overdose.
    American family physician, 1982, Volume: 25, Issue:1

    Topics: Arrhythmias, Cardiac; Bretylium Compounds; Cardiovascular Agents; Cardiovascular Diseases; Digoxin;

1982
Phenytoin-induced hypotension in animals receiving sympathomimetic pressor support.
    The Journal of surgical research, 1980, Volume: 29, Issue:4

    Topics: Animals; Blood Pressure; Dogs; Dopamine; Drug Interactions; Hypotension; Isoproterenol; Myocardial C

1980
Association of intravenous phenytoin toxicity with demographic, clinical, and dosing parameters.
    The American journal of emergency medicine, 1996, Volume: 14, Issue:4

    Topics: Adult; Anticonvulsants; Dose-Response Relationship, Drug; Emergency Service, Hospital; Humans; Hypot

1996
[Neurologic complications following medical treatment of epileptic patients].
    Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952), 1979, Volume: 79, Issue:6

    Topics: Adolescent; Adult; Anticonvulsants; Ataxia; Benzodiazepines; Consciousness Disorders; Dysarthria; Ey

1979
[Anticonvulsants and simultaneous medication - a problem in pregnancy (author's transl)].
    MMW, Munchener medizinische Wochenschrift, 1977, Jun-24, Volume: 119, Issue:25

    Topics: Adult; Anticonvulsants; Antiemetics; Dihydroergotamine; Drug Combinations; Drug Interactions; Drug T

1977
Intravenous phenytoin: clinical and pharmacokinetic aspects.
    Neurology, 1978, Volume: 28, Issue:9 Pt 1

    Topics: Adolescent; Adult; Aged; Female; Half-Life; Humans; Hypotension; Injections, Intravenous; Male; Midd

1978
Dopamine-phenytoin interaction. A cause of hypotension in the critically ill.
    Archives of surgery (Chicago, Ill. : 1960), 1978, Volume: 113, Issue:3

    Topics: Adult; Aged; Animals; Blood Pressure; Critical Care; Dogs; Dopamine; Drug Interactions; Female; Huma

1978
Effects and complications of high efficiency dialysis.
    Nephron, 1975, Volume: 15, Issue:2

    Topics: Barbiturates; Blood Urea Nitrogen; Body Weight; Calcium; Creatinine; Edema; Headache; Humans; Hypote

1975
Hypotension during slow phenytoin infusion in severe sepsis.
    Critical care medicine, 1990, Volume: 18, Issue:9

    Topics: Acute Disease; Aged; Bacterial Infections; Critical Care; Humans; Hypotension; Male; Middle Aged; Ph

1990
Clinical experience with phenytoin prophylaxis in severe preeclampsia.
    American journal of obstetrics and gynecology, 1989, Volume: 161, Issue:5

    Topics: Athetosis; Cesarean Section; Chorea; Delivery, Obstetric; Drug Administration Schedule; Female; Huma

1989
Cyclic antidepressant overdose in children: a proposed treatment protocol.
    Pediatric emergency care, 1986, Volume: 2, Issue:1

    Topics: Absorption; Acetylcholine; Antidepressive Agents, Tricyclic; Arrhythmias, Cardiac; Autonomic Nervous

1986
Phenytoin prophylaxis of cardiotoxicity in experimental amitriptyline poisoning.
    The Journal of pharmacology and experimental therapeutics, 1988, Volume: 245, Issue:1

    Topics: Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Dogs; Electrocardiography; Heart; Hypotens

1988
[Unfavorable and problematic drug combinations. IV].
    Der Internist, 1970, Volume: 11, Issue:11

    Topics: Amphetamine; Ataxia; Bone Marrow; Cerebral Hemorrhage; Depression, Chemical; Dicumarol; Dihydroxyphe

1970
Cardiovascular effects of atelopidtoxin.
    The Journal of pharmacology and experimental therapeutics, 1970, Volume: 175, Issue:2

    Topics: Action Potentials; Animals; Anura; Arrhythmias, Cardiac; Axons; Blood Pressure; Cardiac Output; Card

1970
[Adverse effects of recent ventricular anti-arrhythmia drug].
    La Vie medicale au Canada francais, 1972, Volume: 1, Issue:2

    Topics: Ajmaline; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Bretylium Compounds; Drug Synergism; Electro

1972
[Intoxication with antiarrythmica (author's transl)].
    Padiatrie und Padologie, 1972, Volume: 7, Issue:1

    Topics: Ajmaline; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Child, Preschool; Electrocardiography; Human

1972
[Cardiac toxicity of tricyclic antidepressants].
    Giornale italiano di cardiologia, 1972, Volume: 2, Issue:3

    Topics: Adult; Antidepressive Agents; Arrhythmias, Cardiac; Coronary Disease; Electrocardiography; Female; H

1972
[Comparison of 2 modern antiarrhythmic drugs: lidocaine and diphenylhydantoin].
    Giornale italiano di cardiologia, 1972, Volume: 2, Issue:4

    Topics: Arrhythmias, Cardiac; Brain; Chronic Disease; Hemodynamics; Humans; Hypotension; Lidocaine; Necrosis

1972
[Phenytoin treatment of cardiac arrhythmias].
    Ugeskrift for laeger, 1970, Feb-05, Volume: 132, Issue:6

    Topics: Adult; Aged; Arrhythmias, Cardiac; Digitalis Glycosides; Female; Humans; Hypotension; Injections, In

1970
Cardiac and peripheral vascular effects of diphenylhydantoin sodium.
    The American journal of cardiology, 1966, Volume: 17, Issue:3

    Topics: Animals; Blood Circulation; Dogs; Hemodynamics; Hypotension; Phenytoin

1966