Page last updated: 2024-10-21

phenytoin and Hypoglycemia

phenytoin has been researched along with Hypoglycemia in 32 studies

Hypoglycemia: A syndrome of abnormally low BLOOD GLUCOSE level. Clinical hypoglycemia has diverse etiologies. Severe hypoglycemia eventually lead to glucose deprivation of the CENTRAL NERVOUS SYSTEM resulting in HUNGER; SWEATING; PARESTHESIA; impaired mental function; SEIZURES; COMA; and even DEATH.

Research Excerpts

ExcerptRelevanceReference
"We describe a patient who experienced a prolonged episode of hypoglycemia secondary to an acute voluntary intoxication with diphenylhydantoin 20 g and zopiclone 225 mg."7.69Hypoglycemia associated with phenytoin intoxication. ( Manto, M; Preiser, JC; Vincent, JL, 1996)
"The present report describes a mother and 2 children with leucine-induced hypoglycemia (LIH)."7.67Leucine-induced hypoglycemia in a family: effect of diphenylhydantoin, oxprenolol, and diazoxide. ( Colin, AA; Guttman, H; Hochberg, Z; Spindel, A, 1984)
"Holding EN for phenytoin did not impact attainment of daily nutrition goals and was not associated with increased rates of hypoglycemia."4.31Impact of an enteral nutrition holding guideline on daily nutrition goals in patients taking phenytoin. ( Avramovska, S; Barra, ME; Lo, CK; Qualls, S; Roberts, RJ; Webb, AJ, 2023)
"We describe a patient who experienced a prolonged episode of hypoglycemia secondary to an acute voluntary intoxication with diphenylhydantoin 20 g and zopiclone 225 mg."3.69Hypoglycemia associated with phenytoin intoxication. ( Manto, M; Preiser, JC; Vincent, JL, 1996)
"The present report describes a mother and 2 children with leucine-induced hypoglycemia (LIH)."3.67Leucine-induced hypoglycemia in a family: effect of diphenylhydantoin, oxprenolol, and diazoxide. ( Colin, AA; Guttman, H; Hochberg, Z; Spindel, A, 1984)
"The folic acid absorption test (FAAT) has carried out in 18 normal control subjects; 8 patients with proven atrophy of the jejunal mucosa; 7 patients with gastric ulcus; 17 patients with reactive hypoglycemia; 13 patients with diabetes mellitus, and, finally, 9 epileptic patients treated with diphenylhydantoin (DPH)."3.66Folic acid absorption test in various clinical conditions. ( Bachevalier, J; Botez, MI, 1981)
"In two children treated for hypoglycemia and convulsions with diazoxide and diphenylhydantoin, therapeutic serum diphenylhydantoin levels were not achieved despite doses of diphenylhydantoin of 17 and 29 mg/kg/day, respectively."3.65Drug interaction: diazoxide and diphenylhydantoin. ( Blaskovics, ME; Podosin, RL; Roe, TF, 1975)
"Febrile seizures are a common problem."2.37Febrile seizures: emergency department diagnosis and treatment. ( Ater, SB; Bettis, DB, 1985)

Research

Studies (32)

TimeframeStudies, this research(%)All Research%
pre-199025 (78.13)18.7374
1990's4 (12.50)18.2507
2000's1 (3.13)29.6817
2010's1 (3.13)24.3611
2020's1 (3.13)2.80

Authors

AuthorsStudies
Webb, AJ1
Avramovska, S1
Qualls, S1
Lo, CK1
Roberts, RJ1
Barra, ME1
Witthayapraphakorn, L1
Srilanchakon, K1
Sahakitrungruang, T1
Wacharasindhu, S1
Supornsilchai, V1
Di Gennaro, G1
Quarato, PP1
Colazza, GB1
Mascia, A1
Mari, F1
Manfredi, M1
Clark, WC1
Blackman, HJ1
Preston, JE1
Berger, M1
Tsotsalas, M1
Hochberg, Z1
Spindel, A1
Guttman, H1
Colin, AA1
Botez, MI1
Bachevalier, J1
Manto, M1
Preiser, JC1
Vincent, JL1
Toner, CC1
Stamford, JA1
Hazard, J1
Perlemuter, L1
Bricaire, H1
Luton, JP1
Wechsler, B1
Messing, B1
Halaby, G1
Vidnes, J1
Oyasaeter, S1
Permutt, MA1
Hofeldt, FD1
Lufkin, EG1
Hull, SF1
Davis, JW1
Dippe, S1
Levin, S1
Forsham, PH1
Petro, DJ1
Vannucci, RC1
Kulin, HE1
Holden, KR1
Freeman, JM1
Roe, TF1
Podosin, RL1
Blaskovics, ME1
Takebe, K1
Onuma, T1
Mak, KH1
Chee, M1
Bettis, DB1
Ater, SB1
Lennox-Buchthal, MA1
Christensen, LK1
Skovsted, L1
Hildick-Smith, M1
Brodows, RG1
Campbell, RG1
Josephson, DA1
Perrault, M1
Dry, J1
Kim, CB1
Johnson, WW1
MacMillan, DR1
Yaryura-Tobias, JA1
Leon-Sotomayor, LA1
Wu, NF1
Kushnick, T1
Stambaugh, JE1
Tucker, DC1
Millichap, JG1

Reviews

4 reviews available for phenytoin and Hypoglycemia

ArticleYear
Postprandiol hypoglycemia.
    Diabetes, 1976, Volume: 25, Issue:8

    Topics: Administration, Oral; Adult; Biguanides; Blood Glucose; Diabetes Mellitus; Diet Therapy; Eating; Eva

1976
Neonatal seizures and their treatment.
    Clinics in perinatology, 1975, Volume: 2, Issue:1

    Topics: Anticonvulsants; Diazepam; Humans; Hypocalcemia; Hypoglycemia; Infant, Newborn; Infant, Newborn, Dis

1975
Febrile seizures: emergency department diagnosis and treatment.
    The Journal of emergency medicine, 1985, Volume: 2, Issue:5

    Topics: Blood Cell Count; Blood Glucose; Child, Preschool; Counseling; Diagnosis, Differential; Diazepam; Dr

1985
Febrile convulsions. A reappraisal.
    Electroencephalography and clinical neurophysiology, 1973, Volume: 32

    Topics: Age Factors; Animals; Animals, Newborn; Body Temperature; Brain; Brain Damage, Chronic; Child, Presc

1973

Other Studies

28 other studies available for phenytoin and Hypoglycemia

ArticleYear
Impact of an enteral nutrition holding guideline on daily nutrition goals in patients taking phenytoin.
    Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition, 2023, Volume: 38, Issue:6

    Topics: Adult; Enteral Nutrition; Goals; Humans; Hypoglycemia; Phenytoin

2023
Phenytoin-induced dysglycemia in a child.
    Pediatrics international : official journal of the Japan Pediatric Society, 2017, Volume: 59, Issue:9

    Topics: Anticonvulsants; Humans; Hyperglycemia; Hypoglycemia; Infant; Male; Phenytoin

2017
Hypoglycaemia induced by phenytoin treatment for partial status epilepticus.
    Journal of neurology, neurosurgery, and psychiatry, 2002, Volume: 73, Issue:3

    Topics: Adult; Anticonvulsants; Female; Humans; Hypoglycemia; Phenytoin; Status Epilepticus

2002
Certain factors in aggregated mice d-amphetamine toxicity.
    Archives internationales de pharmacodynamie et de therapie, 1967, Volume: 170, Issue:2

    Topics: Animals; Behavior, Animal; Blood Glucose; Body Temperature; Central Nervous System; Cold Temperature

1967
[Therapy of hypoglycemia in the adult].
    Deutsche medizinische Wochenschrift (1946), 1983, Jul-08, Volume: 108, Issue:27

    Topics: Adenoma, Islet Cell; Adult; Diazoxide; Glucagon; Glucose; Humans; Hypoglycemia; Injections, Intraven

1983
Leucine-induced hypoglycemia in a family: effect of diphenylhydantoin, oxprenolol, and diazoxide.
    Hormone research, 1984, Volume: 20, Issue:4

    Topics: Adult; Child; Child, Preschool; Diazoxide; Female; Genes, Dominant; Humans; Hypoglycemia; Infant; Le

1984
Folic acid absorption test in various clinical conditions.
    Annals of nutrition & metabolism, 1981, Volume: 25, Issue:6

    Topics: Adult; Aged; Atrophy; Diabetes Mellitus; Epilepsy; Folic Acid; Gastrointestinal Diseases; Humans; Hy

1981
Hypoglycemia associated with phenytoin intoxication.
    Journal of toxicology. Clinical toxicology, 1996, Volume: 34, Issue:2

    Topics: Adult; Anticonvulsants; Azabicyclo Compounds; Blood Glucose; Carbohydrate Metabolism; Glucose; Human

1996
Sodium channel blockade unmasks two temporally distinct mechanisms of striatal dopamine release during hypoxia/hypoglycaemia in vitro.
    Neuroscience, 1997, Volume: 81, Issue:4

    Topics: Animals; Dopamine; Electrophysiology; Extracellular Space; Hypoglycemia; Hypoxia, Brain; In Vitro Te

1997
[Action of phenytoin on glycoregulation].
    La Nouvelle presse medicale, 1975, Sep-27, Volume: 4, Issue:31

    Topics: Adenoma, Islet Cell; Adolescent; Animals; Blood Pressure; Child; Child, Preschool; Depression, Chemi

1975
[Inappropriate secretion of insulin by an islet cell adenoma. Trial treatment with diphenylhydantoin].
    Annales de medecine interne, 1976, Volume: 127, Issue:5

    Topics: Adenoma, Islet Cell; Aged; Humans; Hypoglycemia; Male; Pancreatectomy; Pancreatic Neoplasms; Phenyto

1976
Reduced gluconeogenesis due to hyperinsulinism: hormonal and metabolic studies in an infant with hypoglycemia.
    Pediatric research, 1978, Volume: 12, Issue:5

    Topics: Alanine; Child, Preschool; Fatty Acids, Nonesterified; Glucagon; Gluconeogenesis; Glycerol; Humans;

1978
Alimentary reactive hypoglycemia: effects of DBI and dilantin on insulin secretion.
    Military medicine, 1975, Volume: 140, Issue:12

    Topics: Adult; Dietary Carbohydrates; Female; Glucose Tolerance Test; Humans; Hyperinsulinism; Hypoglycemia;

1975
Letter: Diazoxide-diphenylhydantoin interaction.
    The Journal of pediatrics, 1976, Volume: 89, Issue:2

    Topics: Child, Preschool; Diazoxide; Drug Interactions; Drug Therapy, Combination; Epilepsy; Humans; Hypogly

1976
Drug interaction: diazoxide and diphenylhydantoin.
    The Journal of pediatrics, 1975, Volume: 87, Issue:3

    Topics: Administration, Oral; Adolescent; Child, Preschool; Chromatography, Gas; Diazoxide; Drug Therapy, Co

1975
[Abnormal glucose tolerance induced by drugs and chemicals].
    Nihon rinsho. Japanese journal of clinical medicine, 1991, Volume: 49 Suppl

    Topics: Adrenergic beta-Antagonists; Asparaginase; Calcium Channel Blockers; Contraceptives, Oral; Cyclospor

1991
Focal seizure in non-ketotic hyperglycaemia.
    Annals of the Academy of Medicine, Singapore, 1990, Volume: 19, Issue:4

    Topics: Aged; Blood Glucose; Brain Diseases; Diabetes Mellitus, Type 2; Epilepsies, Partial; Female; Humans;

1990
Inhibition of drug metabolism by chloramphenicol.
    Lancet (London, England), 1969, Dec-27, Volume: 2, Issue:7635

    Topics: Aged; Biotransformation; Carbon Isotopes; Chloramphenicol; Chromatography, Thin Layer; Dicumarol; Hu

1969
Epilepsy in the elderly.
    Age and ageing, 1974, Volume: 3, Issue:4

    Topics: Age Factors; Aged; Angiography; Brain Neoplasms; Cerebrovascular Disorders; Dementia; Electroencepha

1974
Control of refractory fasting hypoglycemia in a patient with suspected insulinoma with diphenylhydantoin.
    The Journal of clinical endocrinology and metabolism, 1974, Volume: 38, Issue:1

    Topics: Adenoma, Islet Cell; Aged; Blood Glucose; Female; Humans; Hypoglycemia; Insulin; Phenytoin

1974
Status epilepticus.
    American family physician, 1974, Volume: 10, Issue:4

    Topics: Diazepam; Epilepsy; Humans; Hypocalcemia; Hypoglycemia; Magnesium Deficiency; Paraldehyde; Phenobarb

1974
[Hydantoins today].
    La Revue du praticien, 1972, Dec-21, Volume: 22, Issue:33

    Topics: Arrhythmias, Cardiac; Carbohydrate Metabolism; Central Nervous System; Diabetic Neuropathies; Epilep

1972
Hyperglycemic nonketotic coma in a postpancreatectomy diabetic infant.
    American journal of diseases of children (1960), 1973, Volume: 125, Issue:5

    Topics: Diabetes Mellitus, Type 1; Glucocorticoids; Humans; Hyperglycemia; Hypoglycemia; Infant; Infant, New

1973
Behavioral-gluco-dysrhythmic triad.
    The American journal of psychiatry, 1973, Volume: 130, Issue:7

    Topics: Brain; Diet Therapy; Electroencephalography; Glucose Tolerance Test; Humans; Hypoglycemia; Phenytoin

1973
Cardiac migraine--report of twelve cases.
    Angiology, 1974, Volume: 25, Issue:3

    Topics: Adolescent; Adult; Angina Pectoris; Angiocardiography; Coronary Disease; Diazepam; Diet Therapy; Ele

1974
The Beckwith-Wiedemann syndrome. The exomphalos-macroglossia-gigantism syndrome.
    Clinical pediatrics, 1974, Volume: 13, Issue:5

    Topics: Abnormalities, Multiple; Blood Glucose; Brain Damage, Chronic; Congenital Hypothyroidism; Diagnosis,

1974
Effect of diphenylhydantoin on glucose tolerance in patients with hypoglycemia.
    Diabetes, 1974, Volume: 23, Issue:8

    Topics: Administration, Oral; Adult; Blood Glucose; Body Height; Body Weight; Chromatography, Gas; Female; G

1974
Hyperglycemic effect of diphenylhydantoin.
    The New England journal of medicine, 1969, Aug-21, Volume: 281, Issue:8

    Topics: Child; Diabetes Mellitus; Humans; Hyperglycemia; Hypoglycemia; Phenytoin

1969