phenytoin has been researched along with Hypocalcemia in 32 studies
Hypocalcemia: Reduction of the blood calcium below normal. Manifestations include hyperactive deep tendon reflexes, Chvostek's sign, muscle and abdominal cramps, and carpopedal spasm. (Dorland, 27th ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Fosphenytoin is a prodrug that is metabolized by phosphatases to yield the antiepileptic drug phenytoin plus inorganic phosphate." | 5.31 | Hypocalcemia-like electrocardiographic changes after administration of intravenous fosphenytoin. ( Blackshear, JL; Bondy, LR; Keegan, MT; Lanier, WL, 2002) |
| "To report a case of loss of seizure control due to hypocalcemia resulting from long-term treatment with phenytoin and phenobarbital." | 3.72 | Loss of seizure control due to anticonvulsant-induced hypocalcemia. ( Al-Busairi, WA; Al-Bustan, MA; Al-Mulla, FA; Ali, FE, 2004) |
| "Residents of an institution for the developmentally disabled in northwest Ohio receiving anticonvulsant therapy for six months or more with phenobarbital or phenytoin or both were studied for the prevalence of hypocalcemia and elevated alkaline phosphatase level." | 3.67 | Prevalence of hypocalcemia and elevated serum alkaline phosphatase in patients receiving chronic anticonvulsant therapy. ( Nordlund, DJ; Rodgers, LA; Schmitt, BP, 1984) |
| "His phenytoin dose was increased, and he was started on calcium supplementation." | 1.51 | Paradoxical deterioration in seizure control due to anticonvulsant-induced hypocalcaemia. ( Cachia, MJ; Gauci, Z; Mifsud, S; Rizzo, C, 2019) |
| "Subtle seizures are the commonest type of seizures occurring in the neonatal period." | 1.36 | Management of neonatal seizures. ( Agarwal, R; Deorari, A; Paul, VK; Sankar, JM, 2010) |
| "Fosphenytoin is a prodrug that is metabolized by phosphatases to yield the antiepileptic drug phenytoin plus inorganic phosphate." | 1.31 | Hypocalcemia-like electrocardiographic changes after administration of intravenous fosphenytoin. ( Blackshear, JL; Bondy, LR; Keegan, MT; Lanier, WL, 2002) |
| "Phenytoin treatment was withdrawn, and calcitriol supplementation commenced." | 1.29 | Abnormal bone mineral metabolism after long-term anticonvulsant treatment. ( Alderman, CP; Hill, CL, 1994) |
| " Hypocalcaemia was related to high dosage of anticonvulsant drugs, to multiple drug therapy, and to the use of individual anticonvulsant drugs in the following order, with decreasing order of importance: pheneturide, primidone, phenytoin, phenobarbitone." | 1.25 | Disturbance of calcium metabolism by anticonvulsant drugs. ( Richens, A; Rowe, DJ, 1970) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 25 (78.13) | 18.7374 |
| 1990's | 1 (3.13) | 18.2507 |
| 2000's | 3 (9.38) | 29.6817 |
| 2010's | 3 (9.38) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Gauci, Z | 1 |
| Rizzo, C | 1 |
| Mifsud, S | 1 |
| Cachia, MJ | 1 |
| Nseir, G | 1 |
| Golshayan, D | 1 |
| Barbey, F | 1 |
| Kashyap, AS | 1 |
| Anand, KP | 1 |
| Kashyap, S | 1 |
| Sankar, JM | 1 |
| Agarwal, R | 1 |
| Deorari, A | 1 |
| Paul, VK | 1 |
| Ali, FE | 1 |
| Al-Bustan, MA | 1 |
| Al-Busairi, WA | 1 |
| Al-Mulla, FA | 1 |
| Dooling, EC | 1 |
| Stern, L | 1 |
| Schmitt, BP | 1 |
| Nordlund, DJ | 1 |
| Rodgers, LA | 1 |
| Ammendola, A | 1 |
| Errico, ET | 1 |
| Iannaccone, S | 1 |
| Valerio, P | 1 |
| Tata, MR | 1 |
| Alderman, CP | 1 |
| Hill, CL | 1 |
| Keegan, MT | 1 |
| Bondy, LR | 1 |
| Blackshear, JL | 1 |
| Lanier, WL | 1 |
| Maclay, E | 1 |
| Hadden, DR | 1 |
| McIlrath, EM | 1 |
| Nesbitt, GS | 1 |
| Pupek-Musialik, D | 1 |
| Hosking, DJ | 1 |
| Williams, A | 1 |
| Godwin-Austen, RB | 1 |
| Allison, SP | 1 |
| Friis, B | 1 |
| Sardemann, H | 1 |
| Trabulus, J | 1 |
| Gulsrud, PO | 1 |
| Chopra, IJ | 1 |
| Reunanen, MI | 1 |
| Sotaniemi, EA | 2 |
| Hakkarainen, HK | 2 |
| Holden, KR | 1 |
| Freeman, JM | 1 |
| Bouillon, R | 1 |
| Reynaert, J | 1 |
| Claes, JH | 1 |
| Lissens, W | 1 |
| De Moor, P | 1 |
| Gharib, H | 1 |
| Munoz, JM | 1 |
| Aryanpur, I | 1 |
| Farhoudi, A | 1 |
| Zangeneh, F | 1 |
| Puranen, JA | 1 |
| Lahti, RO | 1 |
| Villareale, M | 1 |
| Gould, LV | 1 |
| Wasserman, RH | 1 |
| Barr, A | 1 |
| Chiroff, RT | 1 |
| Bergstrom, WH | 1 |
| Kraft, D | 1 |
| von Herrath, D | 1 |
| Schaefer, K | 1 |
| Josephson, DA | 1 |
| Hahn, TJ | 1 |
| Hendin, BA | 1 |
| Scharp, CR | 1 |
| Haddad, JG | 1 |
| Snodgrass, GJ | 1 |
| Ray, AK | 1 |
| Rao, DB | 1 |
| Harris, M | 1 |
| Jenkins, MV | 1 |
| Wills, MR | 1 |
| Viukari, NM | 1 |
| Kauko, K | 1 |
| Tammisto, P | 1 |
| Richens, A | 1 |
| Rowe, DJ | 1 |
| Weintraub, M | 1 |
| Schaaf, M | 1 |
| Payne, CA | 1 |
1 review available for phenytoin and Hypocalcemia
| Article | Year |
|---|---|
Neonatal seizures and their treatment.
Topics: Anticonvulsants; Diazepam; Humans; Hypocalcemia; Hypoglycemia; Infant, Newborn; Infant, Newborn, Dis | 1975 |
1 trial available for phenytoin and Hypocalcemia
| Article | Year |
|---|---|
Effect of chronic anticonvulsant therapy on serum 25-hydroxycalciferol levels in adults.
Topics: Adult; Alkaline Phosphatase; Anticonvulsants; Calcium; Clinical Trials as Topic; Epilepsy; Ergocalci | 1972 |
30 other studies available for phenytoin and Hypocalcemia
| Article | Year |
|---|---|
Paradoxical deterioration in seizure control due to anticonvulsant-induced hypocalcaemia.
Topics: Anticonvulsants; Diagnosis, Differential; Epilepsy; Humans; Hypocalcemia; Male; Middle Aged; Phenyto | 2019 |
Phenytoin-associated severe hypocalcemia with seizures in a patient with a TSC2-PKD1 contiguous gene syndrome.
Topics: Adult; Anticonvulsants; Humans; Hypocalcemia; Male; Phenytoin; Renal Insufficiency, Chronic; Syndrom | 2013 |
Case 3-2009: a 9-month-old boy with seizures.
Topics: Anticonvulsants; Humans; Hypocalcemia; Infant; Male; Phenytoin; Seizures; Vitamin D; Vitamin D Defic | 2009 |
Management of neonatal seizures.
Topics: Anticonvulsants; Benzodiazepines; Electroencephalography; Epilepsies, Myoclonic; Humans; Hypocalcemi | 2010 |
Loss of seizure control due to anticonvulsant-induced hypocalcemia.
Topics: Adult; Anticonvulsants; Humans; Hypocalcemia; Male; Phenobarbital; Phenytoin; Seizures; Vitamin D De | 2004 |
Hypomagnesemia with convulsions in a newborn infant. Report of a case associated with maternal hypophosphatemia.
Topics: Calcium; Female; Humans; Hypocalcemia; Hypophosphatemia, Familial; Infant, Newborn; Infant, Newborn, | 1967 |
Prevalence of hypocalcemia and elevated serum alkaline phosphatase in patients receiving chronic anticonvulsant therapy.
Topics: Adolescent; Adult; Alkaline Phosphatase; Calcium; Child; Female; Humans; Hypocalcemia; Male; Middle | 1984 |
[Epilepsy and hypocalcemia. Further considerations on a case].
Topics: Adult; Calcium; Epilepsy; Female; Goiter; Humans; Hypocalcemia; Hypoparathyroidism; Phenobarbital; P | 1981 |
Abnormal bone mineral metabolism after long-term anticonvulsant treatment.
Topics: Aged; Aged, 80 and over; Bone Density; Calcifediol; Diabetes Mellitus, Type 2; Epilepsy, Tonic-Cloni | 1994 |
Hypocalcemia-like electrocardiographic changes after administration of intravenous fosphenytoin.
Topics: Abdominal Pain; Adult; Anticonvulsants; Electroencephalography; Humans; Hypocalcemia; Infusions, Int | 2002 |
Hypocalcaemia and secondary hyperparathyroidism in institutionalised mentally-retarded patients receiving anticonvulsant drugs: a survey of 292 patients.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Child; Child, Preschool; Female; Humans; Hydroxycholecalci | 1978 |
[Calcium and phospate metabolism disorders in patients on long-term diphenylhydantoin therapy].
Topics: Adolescent; Adult; Bone and Bones; Calcium; Epilepsy; Humans; Hypocalcemia; Magnesium; Middle Aged; | 1978 |
Osteomalacia presenting as chorea.
Topics: Adolescent; Alkaline Phosphatase; Chorea; Diagnosis, Differential; Epilepsy, Tonic-Clonic; Humans; H | 1975 |
Neonatal hypocalcaemia after intrauterine exposure to anticonvulsant drugs.
Topics: Adult; Female; Humans; Hypocalcemia; Infant, Newborn; Infant, Newborn, Diseases; Male; Maternal-Feta | 1977 |
Letter: Diphenylhydantoin effects in hypocalcemia.
Topics: Epilepsy, Temporal Lobe; Female; Humans; Hypocalcemia; Middle Aged; Phenytoin | 1976 |
Serum calcium balance during early phase of diphenylhydantoin therapy.
Topics: Adolescent; Adult; Alkaline Phosphatase; Epilepsy; Female; Humans; Hydroxyproline; Hypocalcemia; Mal | 1976 |
The effect of anticonvulsant therapy on serum levels of 25-hydroxy-vitamin D, calcium, and parathyroid hormone.
Topics: Calcium; Cholesterol; Epilepsy; Female; Humans; Hyperparathyroidism, Secondary; Hypocalcemia; Parath | 1975 |
Endocrine manifestations of diphenylhydantoin therapy.
Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Glands; Alkaline Phosphatase; Blood Glucose; End | 1974 |
Congestive heart failure secondary to idiopathic hypoparathyroidism.
Topics: Adolescent; Calcium; Diagnostic Errors; Digoxin; Electrocardiography; Electroencephalography; Epilep | 1974 |
Radiologic bone changes and hypocalcemia with anticonvulsant therapy in epilepsy.
Topics: Adolescent; Adult; Aged; Alkaline Phosphatase; Anticonvulsants; Back Pain; Calcium; Carbamazepine; D | 1972 |
Diphenylhydantoin: effects on calcium metabolism in the chick.
Topics: Animals; Body Weight; Bone and Bones; Calcium; Calcium Radioisotopes; Chickens; Cholecalciferol; Dos | 1974 |
[Anticonvulsants and vitamin D metabolism (author's transl)].
Topics: Animals; Anticonvulsants; Avitaminosis; Body Weight; Calcium; Calcium Radioisotopes; Cholecalciferol | 1974 |
Status epilepticus.
Topics: Diazepam; Epilepsy; Humans; Hypocalcemia; Hypoglycemia; Magnesium Deficiency; Paraldehyde; Phenobarb | 1974 |
Seizures in newborn infants.
Topics: Birth Injuries; Brain; Calcium; Diazepam; Gluconates; Glucose; Humans; Hypocalcemia; Hypoxia; Infant | 1974 |
Calcium metabolism in elderly epileptic patients during anticonvulsant therapy.
Topics: Aged; Alkaline Phosphatase; Calcium; Cerebrovascular Disorders; Drug Therapy, Combination; Epilepsy; | 1974 |
Phenytoin inhibition of parathyroid hormone induced bone resorption in vitro.
Topics: Animals; Bone Resorption; Calcium; Calcium Radioisotopes; Culture Media; Culture Techniques; Hypocal | 1974 |
Anticonvulsant hypocalcaemia.
Topics: Calcium; Epilepsy; Humans; Hypocalcemia; Phenobarbital; Phenytoin | 1972 |
Disturbance of calcium metabolism by anticonvulsant drugs.
Topics: Adolescent; Adult; Aged; Alkaline Phosphatase; Anticonvulsants; Calcium Metabolism Disorders; Enzyme | 1970 |
Neonatal hypocalcemia.
Topics: Female; Humans; Hypocalcemia; Infant, Newborn; Maternal-Fetal Exchange; Phenytoin; Pregnancy; Tetany | 1968 |
Effect of diphenylhydantoin and phenobarbital on overt and latent tetany.
Topics: Adolescent; Adult; Aged; Blood; Calcium; Child; Drug Synergism; Female; Humans; Hypocalcemia; Hypopa | 1966 |